Fgg

Summary

Gene Symbol: Fgg
Description: fibrinogen gamma chain
Alias: 3010002H13Rik, AI256424, fibrinogen gamma-chain, fibrinogen, gamma polypeptide, gamma-fibrinogen
Species: mouse

Top Publications

  1. ncbi Gene and pseudogene of the mouse cation-dependent mannose 6-phosphate receptor. Genomic organization, expression, and chromosomal localization
    T Ludwig
    European Molecular Biology Laboratory, Heidelberg, Federal Republic of Germany
    J Biol Chem 267:12211-9. 1992
  2. ncbi Lack of plasminogen leads to milk stasis and premature mammary gland involution during lactation
    Kirsty A Green
    Finsen Laboratory, Rigshospitalet, Strandboulevarden 49, DK 2100, Copenhagen, Denmark
    Dev Biol 299:164-75. 2006
  3. ncbi High levels of LDL-cholesterol rescue the neonatal mortality associated with afibrinogenemia in mice
    T Iwaki
    J Thromb Haemost 5:624-6. 2007
  4. pmc Aluminum adjuvants elicit fibrin-dependent extracellular traps in vivo
    Michael W Munks
    Department of Immunology, Howard Hughes Medical Institute, Denver, CO 80206, USA
    Blood 116:5191-9. 2010
  5. pmc Leukocyte engagement of fibrin(ogen) via the integrin receptor alphaMbeta2/Mac-1 is critical for host inflammatory response in vivo
    Matthew J Flick
    Children s Hospital Research Foundation and the University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
    J Clin Invest 113:1596-606. 2004
  6. doi Plasmin-driven fibrinolysis facilitates skin tumor growth in a gender-dependent manner
    Andreas Hald
    Finsen Laboratory, Rigshospitalet, Copenhagen Biocenter, Ole Maaloes Vej 5, DK 2200 Copenhagen, Denmark
    FASEB J 26:4445-57. 2012
  7. pmc Amelioration of Duchenne muscular dystrophy in mdx mice by elimination of matrix-associated fibrin-driven inflammation coupled to the αMβ2 leukocyte integrin receptor
    Berta Vidal
    Cell Biology Group, Department of Experimental and Health Sciences, Pompeu Fabra University, CIBER on Neurodegenerative Diseases, Barcelona, Spain
    Hum Mol Genet 21:1989-2004. 2012
  8. pmc Genetic elimination of the binding motif on fibrinogen for the S. aureus virulence factor ClfA improves host survival in septicemia
    Matthew J Flick
    Division of Experimental Hematology and Cancer and Blood Diseases Institute, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Blood 121:1783-94. 2013
  9. ncbi A fibrinogen deficiency accelerates the initiation of LDL cholesterol-driven atherosclerosis via thrombin generation and platelet activation in genetically predisposed mice
    Takayuki Iwaki
    W M Keck Center for Transgene Research, 230 Raclin Carmichael Hall, University of Notre Dame, Notre Dame, IN 46556, USA
    Blood 107:3883-91. 2006
  10. ncbi Fibrin but not adsorbed fibrinogen supports fibronectin assembly by spread platelets. Effects of the interaction of alphaIIb beta3 with the C terminus of the fibrinogen gamma-chain
    Jaehyung Cho
    Molecular and Cellular Pharmacology Program and Department of Medicine, University of Wisconsin Madison School of Medicine, Madison, Wisconsin 53706, USA
    J Biol Chem 280:35490-8. 2005

Research Grants

  1. Non-Immunogenic Peptide Anticoagulant
    David Farrell; Fiscal Year: 2003
  2. ROLE OF FIBRINOGEN IN FIBRINOLYSIS
    David Farrell; Fiscal Year: 2004
  3. Role of gamma' Fibrinogen in Cardiovascular Disease
    David Farrell; Fiscal Year: 2006

Scientific Experts

  • D H Farrell
  • Heyu Ni
  • Fred O Risinger
  • G J Broze
  • Andreas Hald
  • Marketa Jirouskova
  • Matthew J Flick
  • Jay L Degen
  • Francis J Castellino
  • Berta Vidal
  • Huadong Tang
  • F J Castellino
  • Kirsty A Green
  • Victoria A Ploplis
  • Joseph S Palumbo
  • V A Ploplis
  • Takayuki Iwaki
  • N G Copeland
  • N A Jenkins
  • David P Witte
  • T Iwaki
  • K A Hogan
  • D J Gilbert
  • J C Chan
  • Sabine Pfister
  • Evita G van den Herik
  • Vanessa Ruiz-Bonilla
  • Kris A Steinbrecher
  • Antonio L Serrano
  • Esther Ardite
  • Ann C Zovein
  • Pura Munoz-Canoves
  • Monica Suelves
  • Michael W Munks
  • Yan Fu
  • Hong Yang
  • Hongmin Sun
  • Ling Li
  • Yongzhang Luo
  • Malinda D Pinkerton
  • Kathryn E Talmage
  • Xinli Du
  • E D Rosen
  • Leif R Lund
  • Ryan A Adams
  • John Rømer
  • D Cruz-Topete
  • T Kojima
  • I Cornelissen
  • Jaehyung Cho
  • Gwen Tolhurst
  • Mayra J Sandoval-Cooper
  • Eiko Sakao
  • S T Lord
  • R Pawlinski
  • Jian Ming Gu
  • Harini Raghu
  • Emanuel Smeds
  • Magnus Hook
  • Joni M Prasad
  • Anna Janué
  • Germaine L Truisi
  • Vanessa J Jones
  • Patrick P L Tam
  • Diederik W J Dippel
  • Elim Y L Cheung
  • Peter J Koudstaal
  • Yoshiakira Kanai
  • Moniek P M de Maat
  • Poh Lynn Khoo
  • Lonneke M L de Lau
  • Frank W Leebeek
  • Masami Kanai-Azuma
  • David A F Loebel
  • Kirsten A Steiner
  • Melinda Power
  • Heleen M den Hertog
  • Michael S Becker
  • Jennifer J Hofmann
  • John W Kappler
  • Maureen A Shaw
  • Alfonso Luque
  • Netanel A Horowitz
  • Reinhard Fassler
  • Kelley A Barney
  • Megan K Macleod
  • Keith W Kombrinck
  • Fred D Finkelman
  • Timothy F Lane
  • Nichole A Reisdorph

Detail Information

Publications63

  1. ncbi Gene and pseudogene of the mouse cation-dependent mannose 6-phosphate receptor. Genomic organization, expression, and chromosomal localization
    T Ludwig
    European Molecular Biology Laboratory, Heidelberg, Federal Republic of Germany
    J Biol Chem 267:12211-9. 1992
    ..Therefore, it may represent an additional exon of the functional gene. These two features of the pseudogene suggest that expression of the CD-MPR gene may be regulated by use of different promoters and/or alternative splicing...
  2. ncbi Lack of plasminogen leads to milk stasis and premature mammary gland involution during lactation
    Kirsty A Green
    Finsen Laboratory, Rigshospitalet, Strandboulevarden 49, DK 2100, Copenhagen, Denmark
    Dev Biol 299:164-75. 2006
    ....
  3. ncbi High levels of LDL-cholesterol rescue the neonatal mortality associated with afibrinogenemia in mice
    T Iwaki
    J Thromb Haemost 5:624-6. 2007
  4. pmc Aluminum adjuvants elicit fibrin-dependent extracellular traps in vivo
    Michael W Munks
    Department of Immunology, Howard Hughes Medical Institute, Denver, CO 80206, USA
    Blood 116:5191-9. 2010
    ..We conclude that aluminum adjuvants form fibrin-dependent nodules in vivo, that these nodules have properties of extracellular traps, and the nodules are not required for aluminum salts to act as adjuvants...
  5. pmc Leukocyte engagement of fibrin(ogen) via the integrin receptor alphaMbeta2/Mac-1 is critical for host inflammatory response in vivo
    Matthew J Flick
    Children s Hospital Research Foundation and the University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
    J Clin Invest 113:1596-606. 2004
    ..in vivo, gene-targeted mice were generated in which the alpha(M)beta(2)-binding motif within the fibrinogen gamma chain (N(390)RLSIGE(396)) was converted to a series of alanine residues...
  6. doi Plasmin-driven fibrinolysis facilitates skin tumor growth in a gender-dependent manner
    Andreas Hald
    Finsen Laboratory, Rigshospitalet, Copenhagen Biocenter, Ole Maaloes Vej 5, DK 2200 Copenhagen, Denmark
    FASEB J 26:4445-57. 2012
    ..In summary, these data indicate that plasmin-driven fibrinolysis facilitates tumor growth by maintaining patency of the tumor vasculature...
  7. pmc Amelioration of Duchenne muscular dystrophy in mdx mice by elimination of matrix-associated fibrin-driven inflammation coupled to the αMβ2 leukocyte integrin receptor
    Berta Vidal
    Cell Biology Group, Department of Experimental and Health Sciences, Pompeu Fabra University, CIBER on Neurodegenerative Diseases, Barcelona, Spain
    Hum Mol Genet 21:1989-2004. 2012
    ..Thus, local fibrin(ogen) deposition drives dystrophic muscle inflammation and dysfunction, and disruption of fibrin(ogen)-α(M)β(2) interactions may provide a novel strategy for DMD treatment...
  8. pmc Genetic elimination of the binding motif on fibrinogen for the S. aureus virulence factor ClfA improves host survival in septicemia
    Matthew J Flick
    Division of Experimental Hematology and Cancer and Blood Diseases Institute, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Blood 121:1783-94. 2013
    ..These findings indicate that host fibrin(ogen) and bacterial ClfA are dual determinants of virulence and that therapeutic interventions at the level of fibrinogen could be advantageous in S. aureus septicemia...
  9. ncbi A fibrinogen deficiency accelerates the initiation of LDL cholesterol-driven atherosclerosis via thrombin generation and platelet activation in genetically predisposed mice
    Takayuki Iwaki
    W M Keck Center for Transgene Research, 230 Raclin Carmichael Hall, University of Notre Dame, Notre Dame, IN 46556, USA
    Blood 107:3883-91. 2006
    ....
  10. ncbi Fibrin but not adsorbed fibrinogen supports fibronectin assembly by spread platelets. Effects of the interaction of alphaIIb beta3 with the C terminus of the fibrinogen gamma-chain
    Jaehyung Cho
    Molecular and Cellular Pharmacology Program and Department of Medicine, University of Wisconsin Madison School of Medicine, Madison, Wisconsin 53706, USA
    J Biol Chem 280:35490-8. 2005
    ..This interaction is less dominant when platelets adhere to fibrin, resulting in enhanced fibronectin assembly...
  11. ncbi Interplay between P2Y(1), P2Y(12), and P2X(1) receptors in the activation of megakaryocyte cation influx currents by ADP: evidence that the primary megakaryocyte represents a fully functional model of platelet P2 receptor signaling
    Gwen Tolhurst
    Department of Physiology, University of Cambridge, Cambridge, CB2 3EG, United Kingdom
    Blood 106:1644-51. 2005
    ..Thus, direct stimulation of P2Y(1) and P2Y(12) receptors, together with autocrine P2X(1) activation, is responsible for the activation of nonselective cation currents by the platelet agonist ADP...
  12. ncbi Neonatal bleeding and decreased plasma fibrinogen levels in mice modeled after the dysfibrinogen Vlissingen/Frankfurt IV
    K A Hogan
    J Thromb Haemost 2:1484-7. 2004
  13. ncbi Pathophysiologic roles of the fibrinogen gamma chain
    David H Farrell
    Department of Pathology, School of Medicine, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239 3098, USA
    Curr Opin Hematol 11:151-5. 2004
    ..This review summarizes the latest findings on the role of the fibrinogen gamma chain in these processes, and illustrates the potential for therapeutic intervention.
  14. pmc Prothrombotic phenotype of protein Z deficiency
    Z F Yin
    Division of Hematology, Barnes Jewish Hospital at Washington University School of Medicine, 216 South Kingshighway Boulevard, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 97:6734-8. 2000
    ..The results indicate that PZ plays a physiologically important role in the regulation of coagulation...
  15. pmc Fibrin(ogen) exacerbates inflammatory joint disease through a mechanism linked to the integrin alphaMbeta2 binding motif
    Matthew J Flick
    Cincinnati Children s Hospital Research Foundation and University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
    J Clin Invest 117:3224-35. 2007
    ..Thus, fibrin(ogen) is an important, but context-dependent, determinant of arthritis, and one mechanism linking fibrin(ogen) to joint disease is coupled to alphaMbeta2-mediated inflammatory processes...
  16. ncbi Antibody blockade or mutation of the fibrinogen gamma-chain C-terminus is more effective in inhibiting murine arterial thrombus formation than complete absence of fibrinogen
    Marketa Jirouskova
    Rockefeller University, Box 309, 1230 York Ave, New York, NY 10021, USA
    Blood 103:1995-2002. 2004
    ....
  17. ncbi Control of thrombus embolization and fibronectin internalization by integrin alpha IIb beta 3 engagement of the fibrinogen gamma chain
    Heyu Ni
    Center for Blood Research and Department of Pathology, Harvard Medical School, Boston, MA USA
    Blood 102:3609-14. 2003
    ..3) Fibrinogen is internalized through alpha IIb beta 3 engagement of the fibrinogen gamma chain element, and this interaction secondarily controls the fibronectin content of platelets.
  18. ncbi Genetic analyses of ethanol-induced hyperglycemia
    Fred O Risinger
    Department of Behavioral Neuroscience, Portland Alcohol Research Center, Oregon Health and Science University, Portland, OR, USA
    Alcohol Clin Exp Res 27:756-64. 2003
    ..These hypotheses were explored by characterizing blood glucose changes after ethanol exposure in BXD recombinant inbred mice...
  19. ncbi Two-peaked synchronization in day/night expression rhythms of the fibrinogen gene cluster in the mouse liver
    Eiko Sakao
    Department of Biochemistry, Chiba University Graduate School of Medicine, Chiba 260 8670, Japan
    J Biol Chem 278:30450-7. 2003
    ..The fibrinogen gene locus provides a unique system for the study of two-peaked day/night rhythms of gene expression in a synchronized form...
  20. pmc Tissue factor deficiency causes cardiac fibrosis and left ventricular dysfunction
    R Pawlinski
    Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 99:15333-8. 2002
    ..We propose that TF expression by cardiac myocytes provides a secondary hemostatic barrier to protect the heart from hemorrhage...
  21. ncbi Delayed inflammatory responses to endotoxin in fibrinogen-deficient mice
    D Cruz-Topete
    WM Keck Center for Transgene Research and the Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA
    J Pathol 210:325-33. 2006
    ..These results suggest that fibrin(ogen) plays a role as an early mediator in the cross-talk between coagulation and inflammation...
  22. doi Sox17-dependent gene expression and early heart and gut development in Sox17-deficient mouse embryos
    Sabine Pfister
    Embryology Unit, Children s Medical Research Institute, New South Wales, Australia
    Int J Dev Biol 55:45-58. 2011
    ..This is associated with the defective development of the heart in the mutant embryos, which is accompanied by localised loss of Myocd-expressing cardiogenic progenitors and the malformation of the anterior intestinal portal...
  23. doi γ'/total fibrinogen ratio is associated with short-term outcome in ischaemic stroke
    Evita G van den Herik
    Erasmus MC University Medical Center, Department of Neurology, Rotterdam, The Netherlands
    Thromb Haemost 105:430-4. 2011
    ..Increased fibrinogen γ' relative to total fibrinogen levels are associated with unfavourable outcome in the early phase after stroke...
  24. doi Colitis-associated cancer is dependent on the interplay between the hemostatic and inflammatory systems and supported by integrin alpha(M)beta(2) engagement of fibrinogen
    Kris A Steinbrecher
    Divisions of Gastroenterology, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Cancer Res 70:2634-43. 2010
    ....
  25. doi Fibrinogen is required for maintenance of platelet intracellular and cell-surface P-selectin expression
    Hong Yang
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada
    Blood 114:425-36. 2009
    ..recovered this impairment in fibrinogen-deficient (Fg(-/-)) mice, and engagement of the C-terminus of the fibrinogen gamma chain with beta3 integrin was required for this process...
  26. pmc Fibrinogen facilitates the anti-tumor effect of nonnative endostatin
    Huadong Tang
    Cancer Biology Laboratory, Department of Biological Sciences and Biotechnology, Tsinghua University, Qinghua Yuan 1, Beijing 100084, PR China
    Biochem Biophys Res Commun 380:249-53. 2009
    ..Our studies demonstrate that fibrinogen facilitates the anti-tumor effect of nonnative endostatin, which also provides new insights into the novel physiological function of fibrinogen...
  27. pmc Fibrinogen has chaperone-like activity
    Huadong Tang
    National Engineering Laboratory for Anti tumor Protein Therapeutics Tsinghua University, Beijing 100084, China
    Biochem Biophys Res Commun 378:662-7. 2009
    ....
  28. pmc Reduced thrombin generation increases host susceptibility to group A streptococcal infection
    Hongmin Sun
    Department of Internal Medicine, University of Missouri Columbia, USA
    Blood 113:1358-64. 2009
    ....
  29. pmc Fibrinogen drives dystrophic muscle fibrosis via a TGFbeta/alternative macrophage activation pathway
    Berta Vidal
    Program on Differentiation and Cancer, Center for Genomic Regulation CRG, Pompeu Fabra University UPF, E 08003 Barcelona, Spain
    Genes Dev 22:1747-52. 2008
    ..Fibrinogen, by engaging its alphavbeta3 receptor on fibroblasts, also directly promotes collagen synthesis. These data unveil a profibrotic role of fibrinogen deposition in muscle dystrophy...
  30. doi Profibrinolytic effects of metalloproteinases during skin wound healing in the absence of plasminogen
    Kirsty A Green
    Finsen Laboratory, Rigshospitalet, Copenhagen Biocenter, Copenhagen, Denmark
    J Invest Dermatol 128:2092-101. 2008
    ..Furthermore, these in vivo data reveal that galardin-sensitive metalloproteinases mediate compensatory fibrinolysis to facilitate wound healing in the absence of plasmin...
  31. pmc The fibrin-derived gamma377-395 peptide inhibits microglia activation and suppresses relapsing paralysis in central nervous system autoimmune disease
    Ryan A Adams
    Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093, USA
    J Exp Med 204:571-82. 2007
    ....
  32. ncbi Disruption of the endothelial cell protein C receptor gene in mice causes placental thrombosis and early embryonic lethality
    Jian Ming Gu
    Cardiovascular Biology, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA
    J Biol Chem 277:43335-43. 2002
    ..We conclude that EPCR is essential for normal embryonic development. Moreover, EPCR plays a key role in preventing thrombosis at the maternal-embryonic interface...
  33. pmc Fibrinogen stabilizes placental-maternal attachment during embryonic development in the mouse
    Takayuki Iwaki
    W M Keck Center for Transgene Research, Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, USA
    Am J Pathol 160:1021-34. 2002
    ..The results of these studies demonstrate that maternal Fg plays a critical role in maintenance of pregnancy in mice, both by supporting proper development of fetal-maternal vascular communication and stabilization of embryo implantation...
  34. ncbi Characterization of the mouse loricrin gene: linkage with profilaggrin and the flaky tail and soft coat mutant loci on chromosome 3
    J A Rothnagel
    Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030
    Genomics 23:450-6. 1994
    ..These mouse mutants exhibit a number of changes in their integument, suggesting that abnormalities in these genes may contribute to the mutant phenotype...
  35. ncbi The gamma fibrinogen gene (FGG) maps to chromosome 17 in both cattle and sheep
    S E Johnson
    CSIRO, Division of Tropical Animal Production, University of Queensland, Australia
    Cytogenet Cell Genet 62:176-80. 1993
    The gamma fibrinogen gene (FGG) was localised in both cattle and sheep using in situ hybridisation. The probe employed was a 1-kb bovine cDNA fragment...
  36. ncbi Chromosomal localization of the Ox-44 (CD53) leukocyte antigen gene in man and rodents
    T Taguchi
    Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111
    Cytogenet Cell Genet 64:217-21. 1993
    ..Comparative mapping data presented in this report demonstrate conservation of synteny within the region encompassing this gene in mouse (Cd53), human (CD53), and rat (CD53)...
  37. ncbi Conserved synteny between pig chromosome 8 and human chromosome 4 but rearranged and distorted linkage maps
    H Ellegren
    Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala
    Genomics 17:599-603. 1993
    ..Since loci from this synteny group are found on two cattle chromosomes, the bovine rearrangement must have occurred after the split of Suidae and Bovidae within Artiodactyla...
  38. ncbi trkC, a receptor for neurotrophin-3, is widely expressed in the developing nervous system and in non-neuronal tissues
    L Tessarollo
    Molecular Embryology Section, ABL Basic Research Program, NCI Frederick Cancer Research and Development Center, Maryland 21702 1201
    Development 118:463-75. 1993
    ..Alignment with available chromosomal maps identify possible linkage between the Trk genes and known neurological mutations...
  39. pmc A Mef2 gene that generates a muscle-specific isoform via alternative mRNA splicing
    J F Martin
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston 77030
    Mol Cell Biol 14:1647-56. 1994
    ..The complexity of the MEF2 family of regulatory proteins provides the potential for fine-tuning of transcriptional responses as a consequence of combinatorial interactions among multiple MEF2 isoforms encoded by the four Mef2 genes...
  40. ncbi Multilocus markers for mouse genome analysis: PCR amplification based on single primers of arbitrary nucleotide sequence
    J H Nadeau
    Jackson Laboratory, Bar Harbor, Maine 04609
    Mamm Genome 3:55-64. 1992
    ..Finally, linkage for seven products was established on five chromosomes. These characteristics establish single primer PCR as a powerful method for mouse genome analysis...
  41. pmc Beta1 integrin establishes endothelial cell polarity and arteriolar lumen formation via a Par3-dependent mechanism
    Ann C Zovein
    Department of Molecular, Cellular, and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Dev Cell 18:39-51. 2010
    ..Combined, our findings demonstrate that beta1 integrin functions upstream of Par3 as part of a molecular cascade required for endothelial cell polarity and lumen formation...
  42. ncbi Interspersed repetitive element polymerase chain reaction product mapping using a mouse interspecific backcross
    R D Cox
    Genome Analysis Laboratory, Imperial Cancer Research Fund Laboratories, London, United Kingdom
    Genomics 10:375-84. 1991
    ..We anticipate that many more markers remain to be characterized in this valuable new source of polymorphism...
  43. ncbi Differential effects of topical retinoic acid application on keratin K1 and filaggrin expression in mouse epidermis
    C Lutzow-Holm
    Institute of Pathology, Medical Faculty, University of Oslo, National Hospital, Norway
    Differentiation 57:179-85. 1994
    ..These results suggested that the effect of RA on epidermal differentiation is secondary to its effect on proliferation, as determined by the altered cellular age distribution following regenerative proliferation...
  44. ncbi Chromosomal locations of genes encoding 2',3' cyclic nucleotide 3'-phosphodiesterase and glial fibrillary acidic protein in the mouse
    L Bernier
    Department of Biochemistry, McGill University, Montreal, Quebec, Canada
    J Neurosci Res 20:497-504. 1988
    ..We have localized the GFAP gene to distal chromosome 11 in the mouse. There are two genetic loci identified by CNP probes, one is closely linked to the GFAP gene, and the other maps to chromosome 3...
  45. ncbi Linkage map of 10 polymorphic markers on rat chromosome 2
    H Zha
    Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892
    Cytogenet Cell Genet 63:117-23. 1993
    ..The markers form a single linkage group covering 47.9 cM with the following order: D2N1R-D2N28-FGG (gamma fibrinogen)-PKLR (liver and RBC pyruvate kinase)-ATP1A1 (the alpha-1 polypeptide of Na+/K+ transporting ATPase)-HSD3B (..
  46. pmc Impaired platelet aggregation and sustained bleeding in mice lacking the fibrinogen motif bound by integrin alpha IIb beta 3
    K Holmbäck
    Division of Developmental Biology, Children s Hospital Research Foundation, Cincinnati, OH 45229, USA
    EMBO J 15:5760-71. 1996
    ..injury and vasoocclusive disease, and to test the prevailing hypothesis that the C-terminal segment of the fibrinogen gamma chain is essential for alpha IIb beta 3 binding, we have used gene-targeting technology in mice to eliminate the ..
  47. ncbi Chromosomal mapping of five highly conserved murine homologues of the Drosophila RING finger gene seven-in-absentia
    A J Holloway
    Trescowthick Research Laboratories, Peter MacCallum Cancer Institute, Melbourne, Victoria, Australia
    Genomics 41:160-8. 1997
    ..By comparing the complexity of the Siah genes in these two mammalian species we have gained further insight into which members of this murine multigene family are likely to be functional...
  48. ncbi Synthesis of a mouse model of the dysfibrinogen Vlissingen/Frankfurt IV
    K A Hogan
    Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599 7525, USA
    Ann N Y Acad Sci 936:117-21. 2001
    ..These heterozygous mice provide the first opportunity to examine the association of thrombophilia and dysfibrinogenemia in a controlled genetic background...
  49. ncbi Genomic organization of the Shc-related phosphotyrosine adapters and characterization of the full-length Sck/ShcB: specific association of p68-Sck/ShcB with pp135
    T Kojima
    Department of Molecular Genetic Research, National Institute for Longevity Sciences NILS, Morioka cho, Oobu, Aichi, 474 8522, Japan
    Biochem Biophys Res Commun 284:1039-47. 2001
    ..The Sck-pp135 interaction was reduced by Src kinase inhibitors. These results suggest that Sck, but not N-Shc nor Shc, transmit signals in conjunction with pp135 following Src activation and/or calcium entry in the cell...
  50. pmc The characterization of mice with a targeted combined deficiency of protein c and factor XI
    J C Chan
    Department of Chemistry and Biochemistry, W M Keck Center for Transgene Research, and the Freimann Life Science Center, University of Notre Dame, Notre Dame, Indiana 46556, USA
    Am J Pathol 158:469-79. 2001
    ....
  51. pmc Complete antithrombin deficiency in mice results in embryonic lethality
    K Ishiguro
    First Department of Internal Medicine, Nagoya University School of Medicine, Nagoya, Japan
    J Clin Invest 106:873-8. 2000
    ..These findings suggest that antithrombin is essential for embryonic survival and that it plays an important role in regulation of blood coagulation in the myocardium and liver...
  52. pmc A total fibrinogen deficiency is compatible with the development of pulmonary fibrosis in mice
    V A Ploplis
    W M Keck Center for Transgene Research and the Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, USA
    Am J Pathol 157:703-8. 2000
    ..This indicates that Fg and/or Fn are not essential for the development of bleomycin-induced pulmonary fibrosis...
  53. pmc Combined factor VII/protein C deficiency results in intrauterine coagulopathy in mice
    J C Chan
    W M Keck Center for Transgene Research and the Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, USA
    J Clin Invest 105:897-903. 2000
    ..The presence of fibrin in embryos in the absence of fetal FVII suggests that significant clot-generating potential exists outside of the embryonic factor VII-dependent pathway...
  54. ncbi The neurobeachin gene (Nbea) identifies a new region of homology between mouse central chromosome 3 and human chromosome 13q13
    D J Gilbert
    Mammalian Genetics Laboratory, ABL Basic Research Program, NCI Frederick Cancer Research and Development Center, Frederick, Maryland 21702, USA
    Mamm Genome 10:1030-1. 1999
  55. pmc cDNA cloning, expression pattern, and chromosomal localization of Mlf1, murine homologue of a gene involved in myelodysplasia and acute myeloid leukemia
    J K Hitzler
    Department of Experimental Oncology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Am J Pathol 155:53-9. 1999
    ....
  56. ncbi Tissue factor pathway inhibitor gene disruption
    G J Broze
    Division of Hematology, Washington University School of Medicine, Barnes Jewish Hospital, St Louis, MO 63110, USA
    Blood Coagul Fibrinolysis 9:S89-92. 1998
    ..Human TFPI-deficient embryos may suffer a similar fate as an individual with TFPI deficiency has not been identified...
  57. ncbi Mapping a gene for combined hyperlipidaemia in a mutant mouse strain
    L W Castellani
    Department of Medicine, University of California, Los Angeles 90095, USA
    Nat Genet 18:374-7. 1998
    ..This region is syntenic to human chromosome 1q21-q23, which has recently been shown to harbour a gene associated with FCHL in families from a Finnish isolate...
  58. ncbi Mice lacking factor VII develop normally but suffer fatal perinatal bleeding
    E D Rosen
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, Leuven, Belgium
    Nature 390:290-4. 1997
    ..Thus, the TF-/- embryonic lethal and the FVII-/- survival-phenotypes suggest a role for TF during embryogenesis beyond fibrin formation...
  59. ncbi Mapping and gene order of U1 small nuclear RNA, endogenous viral env sequence, amylase, and alcohol dehydrogenase-3 on mouse chromosome 3
    C Blatt
    Agouron Institute, La Jolla, California
    Somat Cell Mol Genet 14:133-42. 1988
    ..the following suggested gene order between the newly assigned genes and previously mapped genes: gamma-fibrinogen (Fgg), Xmmv-22 of mink cell focus-inducing (MCF) virus, U1b small nuclear RNA gene cluster (Rnu-1b), amylase (Amy-1,2), ..
  60. ncbi Four novel members of the connexin family of gap junction proteins. Molecular cloning, expression, and chromosome mapping
    J A Haefliger
    Department of Anatomy and Cellular Biology, Harvard Medical School, Boston, Massachusetts 02115
    J Biol Chem 267:2057-64. 1992
    ..Chromosomal mapping studies indicate that Cx26 and Cx46 are tightly linked on chromosome 14, and Cx37 and Cx31.1 are linked on chromosome 4, while the rest of the connexin genes are dispersed...
  61. ncbi Endogenous nonecotropic proviruses mapped with oligonucleotide probes from the long terminal repeat region
    W N Frankel
    Jackson Laboratory, Bar Harbor, Maine 04609
    Mamm Genome 5:275-81. 1994
    ..Together with proviruses identified previously with env probes, the LTR probe-reactive elements represent the majority of endogenous murine leukemia proviruses in the mouse genome...
  62. ncbi Genomic mapping of intracisternal A-particle proviral elements
    K K Lueders
    Laboratory of Biochemistry, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892
    Mamm Genome 4:69-77. 1993
    ..Some of the loci have also been scored in the CXB RI set. The IAP LS loci can provide a significant number of markers with a recognized genetic organization to the mouse genome map...
  63. ncbi A hamster antibody to the mouse fibrinogen gamma chain inhibits platelet-fibrinogen interactions and FXIIIa-mediated fibrin cross-linking, and facilitates thrombolysis
    M Jirouskova
    Department of Medicine, Mount Sinai School of Medicine, New York, NY, USA
    Thromb Haemost 86:1047-56. 2001
    ..These data provide evidence that the C-terminus of mouse fibrinogen gamma chain, like that of human fibrinogen, is involved in fibrinogen binding to platelets and FXIIIa-mediated cross-..

Research Grants3

  1. Non-Immunogenic Peptide Anticoagulant
    David Farrell; Fiscal Year: 2003
    ..At the conclusion of these studies, essential milestones will be achieved for Phase II development of the gamma' peptide as a pharmacologic anticoagulant. ..
  2. ROLE OF FIBRINOGEN IN FIBRINOLYSIS
    David Farrell; Fiscal Year: 2004
    ..The results from the experiments in this proposal should provide new knowledge about the process of fibrinolysis that may lead to ways of modulating fibrin clot stability and clot lysis in vivo. ..
  3. Role of gamma' Fibrinogen in Cardiovascular Disease
    David Farrell; Fiscal Year: 2006
    ..2) To determine the relationship between fibrinogen isoforms and established cardiovascular disease risk factors. 3) To determine if the fibrinogen isoforms in plasma are independently associated with CVD. ..