Fgfr1

Summary

Gene Symbol: Fgfr1
Description: fibroblast growth factor receptor 1
Alias: AW208770, Eask, FGFR-I, FLG, Fgfr-1, Flt-2, Hspy, MFR, bFGF-R-1, c-fgr, fibroblast growth factor receptor 1, basic fibroblast growth factor receptor 1, proto-oncogene c-Fgr
Species: mouse

Top Publications

  1. ncbi Cloning and expression of fibroblast growth factor receptor-1 isoforms in the mouse heart: evidence for isoform switching during heart development
    Y Jin
    Department of Physiology, University of Manitoba, Winnipeg, Canada
    J Mol Cell Cardiol 26:1449-59. 1994
  2. ncbi Hush puppy: a new mouse mutant with pinna, ossicle, and inner ear defects
    Henry Pau
    MRC Institute of Hearing Research, University Park, Nottingham, UK
    Laryngoscope 115:116-24. 2005
  3. pmc FGF18 is required for normal cell proliferation and differentiation during osteogenesis and chondrogenesis
    Norihiko Ohbayashi
    Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Sakyo ku, Kyoto 606 8501, Japan
    Genes Dev 16:870-9. 2002
  4. ncbi Genome-wide, large-scale production of mutant mice by ENU mutagenesis
    M H Hrabe de Angelis
    Institute of Experimental Genetics, GSF Research Center for Environment and Health, Neuherberg, Germany
    Nat Genet 25:444-7. 2000
  5. ncbi Conditional inactivation of FGF receptor 2 reveals an essential role for FGF signaling in the regulation of osteoblast function and bone growth
    Kai Yu
    Department of Molecular Biology and Pharmacology, Washington University Medical School, Campus Box 8103, 660 S Euclid Avenue, St Louis, Missouri 63110, USA
    Development 130:3063-74. 2003
  6. ncbi Responsiveness of developing dental tissues to fibroblast growth factors: expression of splicing alternatives of FGFR1, -2, -3, and of FGFR4; and stimulation of cell proliferation by FGF-2, -4, -8, and -9
    P Kettunen
    Developmental Biology Programme, University of Helsinki, Finland
    Dev Genet 22:374-85. 1998
  7. doi S100B protein regulates myoblast proliferation and differentiation by activating FGFR1 in a bFGF-dependent manner
    Francesca Riuzzi
    Department of Experimental Medicine and Biochemical Sciences and Istituto Interuniversitario di Miologia, University of Perugia, Via del Giochetto, 06122 Perugia, Italy
    J Cell Sci 124:2389-400. 2011
  8. ncbi Fibroblast growth factor signalling in the hair growth cycle: expression of the fibroblast growth factor receptor and ligand genes in the murine hair follicle
    T A Rosenquist
    Department of Anatomy, University of California at San Francisco 94143 0452, USA
    Dev Dyn 205:379-86. 1996
  9. pmc Angiopoietins 3 and 4: diverging gene counterparts in mice and humans
    D M Valenzuela
    Regeneron Pharmaceuticals, Inc, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA
    Proc Natl Acad Sci U S A 96:1904-9. 1999
  10. ncbi Syndecan-3 and syndecan-4 specifically mark skeletal muscle satellite cells and are implicated in satellite cell maintenance and muscle regeneration
    D D Cornelison
    Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, Colorado 80309, USA
    Dev Biol 239:79-94. 2001

Research Grants

  1. Peptide Regulators of Angiogenesis
    Michael Simons; Fiscal Year: 2005
  2. PROTEOMIC MAPPING OF MYELIN AND ITS MEMBRANE SUBDOMAINS
    Rashmi Bansal; Fiscal Year: 2009

Scientific Experts

Detail Information

Publications148 found, 100 shown here

  1. ncbi Cloning and expression of fibroblast growth factor receptor-1 isoforms in the mouse heart: evidence for isoform switching during heart development
    Y Jin
    Department of Physiology, University of Manitoba, Winnipeg, Canada
    J Mol Cell Cardiol 26:1449-59. 1994
    ..The bFGF receptor-1 FGFR1) exists in short and long isoforms due to alternate RNA splicing...
  2. ncbi Hush puppy: a new mouse mutant with pinna, ossicle, and inner ear defects
    Henry Pau
    MRC Institute of Hearing Research, University Park, Nottingham, UK
    Laryngoscope 115:116-24. 2005
    ..Furthermore, the authors investigated where the mutation responsible for these defects was located in the mouse genome...
  3. pmc FGF18 is required for normal cell proliferation and differentiation during osteogenesis and chondrogenesis
    Norihiko Ohbayashi
    Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Sakyo ku, Kyoto 606 8501, Japan
    Genes Dev 16:870-9. 2002
    ..Conversely, chondrocyte proliferation and the number of differentiated chondrocytes are increased. Therefore, FGF18 appears to regulate cell proliferation and differentiation positively in osteogenesis and negatively in chondrogenesis...
  4. ncbi Genome-wide, large-scale production of mutant mice by ENU mutagenesis
    M H Hrabe de Angelis
    Institute of Experimental Genetics, GSF Research Center for Environment and Health, Neuherberg, Germany
    Nat Genet 25:444-7. 2000
    ..Our mutant lines are freely accessible to non-commercial users (for information, see http://www.gsf.de/ieg/groups/enu-mouse.html)...
  5. ncbi Conditional inactivation of FGF receptor 2 reveals an essential role for FGF signaling in the regulation of osteoblast function and bone growth
    Kai Yu
    Department of Molecular Biology and Pharmacology, Washington University Medical School, Campus Box 8103, 660 S Euclid Avenue, St Louis, Missouri 63110, USA
    Development 130:3063-74. 2003
    ..Although differentiation of the osteoblast lineage was not disturbed, the proliferation of osteoprogenitors and the anabolic function of mature osteoblasts were severely affected...
  6. ncbi Responsiveness of developing dental tissues to fibroblast growth factors: expression of splicing alternatives of FGFR1, -2, -3, and of FGFR4; and stimulation of cell proliferation by FGF-2, -4, -8, and -9
    P Kettunen
    Developmental Biology Programme, University of Helsinki, Finland
    Dev Genet 22:374-85. 1998
    ..The expression patterns of FGFR1 -2, and -3 were completely different, and the two splicing variants of FGFR1 and 2 exhibited different expression ..
  7. doi S100B protein regulates myoblast proliferation and differentiation by activating FGFR1 in a bFGF-dependent manner
    Francesca Riuzzi
    Department of Experimental Medicine and Biochemical Sciences and Istituto Interuniversitario di Miologia, University of Perugia, Via del Giochetto, 06122 Perugia, Italy
    J Cell Sci 124:2389-400. 2011
    ..that S100B increases and/or stabilizes the binding of basic fibroblast growth factor (bFGF) to bFGF receptor 1 (FGFR1) by interacting with bFGF, thereby enhancing FGFR1 activation and the mitogenic and anti-myogenic effects of FGFR1...
  8. ncbi Fibroblast growth factor signalling in the hair growth cycle: expression of the fibroblast growth factor receptor and ligand genes in the murine hair follicle
    T A Rosenquist
    Department of Anatomy, University of California at San Francisco 94143 0452, USA
    Dev Dyn 205:379-86. 1996
    ..During anagen, we detected Fgfr1 RNA in the dermal papilla, Fgfr2 RNA in hair matrix cells near the dermal papilla, Fgfr3 RNA in pre-cuticle cells ..
  9. pmc Angiopoietins 3 and 4: diverging gene counterparts in mice and humans
    D M Valenzuela
    Regeneron Pharmaceuticals, Inc, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA
    Proc Natl Acad Sci U S A 96:1904-9. 1999
    ..Angiopoietin-3 and angiopoietin-4 have very different distributions in their respective species, and angiopoietin-3 appears to act as an antagonist, whereas angiopoietin-4 appears to function as an agonist...
  10. ncbi Syndecan-3 and syndecan-4 specifically mark skeletal muscle satellite cells and are implicated in satellite cell maintenance and muscle regeneration
    D D Cornelison
    Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, Colorado 80309, USA
    Dev Biol 239:79-94. 2001
    ....
  11. ncbi Fibroblast growth factor 10 is required for survival and proliferation but not differentiation of intestinal epithelial progenitor cells during murine colon development
    Frederic G Sala
    UMR144 CNRS Institut Curie, 75248 Paris Cedex 05, France
    Dev Biol 299:373-85. 2006
    ..Our work unravels for the first time the pivotal role of FGF10 in the survival and proliferation of the colonic epithelium, biological activities which are essential for colonic crypt formation...
  12. ncbi FGF signaling acts upstream of the NOTCH and WNT signaling pathways to control segmentation clock oscillations in mouse somitogenesis
    Matthias B Wahl
    Stowers Institute for Medical Research, Kansas City, MO 64110, USA
    Development 134:4033-41. 2007
    ..Here, we show that conditional deletion of the FGF receptor gene Fgfr1 abolishes FGF signaling in the mouse PSM, resulting in an arrest of the dynamic cyclic gene expression and ..
  13. ncbi Ligand specificity and heparin dependence of fibroblast growth factor receptors 1 and 3
    D M Ornitz
    Howard Hughes Medical Institute, Boston, Massachusetts
    J Biol Chem 267:16305-11. 1992
    ..Both receptor binding and growth factor-mediated mitogenicity are dependent on heparin. Heparin-binding growth factor activity can thus be regulated by proteoglycans and by the type of FGF receptor expressed on the target cell...
  14. ncbi Initiation of mammalian liver development from endoderm by fibroblast growth factors
    J Jung
    Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Box G J363, Providence, RI 02912, USA
    Science 284:1998-2003. 1999
    ..Thus, different FGF signals appear to initiate distinct phases of liver development during mammalian organogenesis...
  15. ncbi Differential regulation of endochondral bone growth and joint development by FGFR1 and FGFR3 tyrosine kinase domains
    Q Wang
    Department of Molecular Biology and Pharmacology, Washington University Medical School, Campus Box 8103, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Development 128:3867-76. 2001
    ..In several cultured cell lines, FGFR1 transmits a potent mitogenic signal, whereas FGFR3 has little or no mitogenic activity...
  16. ncbi Expression of FGF receptors 1, 2, 3 in the embryonic and postnatal mouse brain compared with Pdgfralpha, Olig2 and Plp/dm20: implications for oligodendrocyte development
    Rashmi Bansal
    Department of Neuroscience, University of Connecticut Medical School, Farmington, Conn 06030 3401, USA
    Dev Neurosci 25:83-95. 2003
    Fibroblast growth factors (FGF) receptors FgfR1, FgfR2 and FgfR3 are differentially regulated during oligodendrocyte (OL) maturation in vitro: FgfR3 is expressed by OL progenitors whereas FgfR2 is expressed by differentiated OLs [Mol ..
  17. ncbi Apoptosis, proliferation and gene expression patterns in mouse developing tongue
    Xuguang Nie
    Section of Anatomy and Cell Biology, Department of Biomedicine, University of Bergen, Jonas Lies V91, 5009, Bergen, Norway
    Anat Embryol (Berl) 210:125-32. 2005
    ..Fgf2 was seen in the tongue muscles at the late embryonic and postnatal stages. These results suggest that Bmp and Fgf signalling regulates tongue development at multiple stages, possibly related to proliferation and differentiation...
  18. pmc The neuronal PAS domain protein 3 transcription factor controls FGF-mediated adult hippocampal neurogenesis in mice
    Andrew A Pieper
    Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 102:14052-7. 2005
    ..We propose that a deficiency in adult neurogenesis may cause the behavioral and neuroanatomical abnormalities seen in Npas3-/- mice, and we speculate that impaired neurogenesis may be involved in the pathophysiology of schizophrenia...
  19. pmc The FGF system has a key role in regulating vascular integrity
    Masahiro Murakami
    Angiogenesis Research Center and Section of Cardiology, Dartmouth Medical School, Lebanon, New Hampshire, USA
    J Clin Invest 118:3355-66. 2008
    ..Thus, FGF signaling plays a key role in the maintenance of vascular integrity...
  20. ncbi Murine FGFR-1 is required for early postimplantation growth and axial organization
    C X Deng
    Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115
    Genes Dev 8:3045-57. 1994
    We have explored the role of fibroblast growth factor receptor 1 (FGFR-1) in early embryonic development using three experimental systems: genetically deficient mice, in vitro blastocyst culture, and FGFR-1-deficient embryonic stem cells...
  21. pmc FGF9 regulates early hypertrophic chondrocyte differentiation and skeletal vascularization in the developing stylopod
    Irene H Hung
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, Campus Box 8103, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Dev Biol 307:300-13. 2007
    ..In developing stylopod elements, FGF9 promotes chondrocyte hypertrophy at early stages and regulates vascularization of the growth plate and osteogenesis at later stages of skeletal development...
  22. ncbi Fibroblast-growth-factor receptor mutations in human skeletal disorders
    M Muenke
    Children s Hospital of Philadelphia, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia 19104 4399, USA
    Trends Genet 11:308-13. 1995
    ..Recently, unique mutations in three human FGFR-encoding genes (FGFR1-3) have been identified as the cause of a variety of skeletal disorders...
  23. ncbi Fibroblast growth factor receptor signalling has a role in lobuloalveolar development of the mammary gland
    D Jackson
    Laboratory of Viral Carcinogenesis, Imperial Cancer Research Fund, London, UK
    J Cell Sci 110:1261-8. 1997
    ..While expression of DN-FGFR1(IIIc) showed no discernible phenotype, a similar kinase negative form of FGFR2(IIIb) caused a marked impairment of ..
  24. ncbi FGF signaling through FGFR1 is required for olfactory bulb morphogenesis
    Jean M Hebert
    Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
    Development 130:1101-11. 2003
    ..telencephalon, we address the role of FGF signaling directly in vivo by abolishing expression of the FGF receptor Fgfr1. In the Fgfr1-deficient telencephalon, AP patterning is largely normal...
  25. pmc Dusp6 (Mkp3) is a negative feedback regulator of FGF-stimulated ERK signaling during mouse development
    Chaoying Li
    Department of Human Genetics, University of Utah, 15 N 2030 E RM 2100, Salt Lake City, UT 84112 5330, USA
    Development 134:167-76. 2007
    ....
  26. pmc Differential splicing in the extracellular region of fibroblast growth factor receptor 1 generates receptor variants with different ligand-binding specificities
    S Werner
    Department of Medicine, Howard Hughes Medical Institute, University of California, San Francisco 94143 0724
    Mol Cell Biol 12:82-8. 1992
    We have cloned a genomic region of the murine fibroblast growth factor (FGF) receptor 1 (FGFR1) gene that includes three alternative exons for the third immunoglobulinlike domain in the extracellular region of the receptor...
  27. ncbi Two FGF receptor genes are differentially expressed in epithelial and mesenchymal tissues during limb formation and organogenesis in the mouse
    K G Peters
    Howard Hughes Medical Institute, Department of Medicine, University of California, San Francisco 94147
    Development 114:233-43. 1992
    ..FGF receptor genes might have specific functions, we compared the localization of mRNA for two FGF receptor genes, FGFR1 (the flg gene product) and FGFR2 (the bek gene product), during limb formation and organogenesis in mouse embryos (..
  28. ncbi Developmental expression of two murine fibroblast growth factor receptors, flg and bek
    A Orr-Urtreger
    Department of Chemical Immunology, Weizmann Institute of Science, Rehovot, Israel
    Development 113:1419-34. 1991
    Developmental expression of two closely related fibroblast growth factor receptors, bek and flg, is described from early postimplantation until advanced organogenesis...
  29. ncbi fgfr-1 is required for embryonic growth and mesodermal patterning during mouse gastrulation
    T P Yamaguchi
    Samuel Lunenfeld Research Institute SLRI, Mount Sinai Hospital, Toronto, Ontario, Canada
    Genes Dev 8:3032-44. 1994
    ..We have mutated the gene for fibroblast growth factor receptor 1 (fgfr-1) in the mouse to genetically dissect the role of FGF signaling during development...
  30. ncbi Expression of a truncated FGF receptor results in defective lens development in transgenic mice
    M L Robinson
    Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Development 121:3959-67. 1995
    ..in normal lens development was evaluated by lens-specific synthesis of a kinase-deficient FGF receptor type I (FGFR1) in transgenic mice...
  31. ncbi Antisense targeting of basic fibroblast growth factor and fibroblast growth factor receptor-1 in human melanomas blocks intratumoral angiogenesis and tumor growth
    Y Wang
    Department of Pathology, University of Pittsburgh, Pennsylvania 15213, USA
    Nat Med 3:887-93. 1997
    ..Thus, inhibition of bFGF/FGFR-1-mediated signaling may open a new avenue for the treatment of advanced-stage melanomas...
  32. ncbi Expression patterns of Twist and Fgfr1, -2 and -3 in the developing mouse coronal suture suggest a key role for twist in suture initiation and biogenesis
    D Johnson
    Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, UK
    Mech Dev 91:341-5. 2000
    ..The identification of heterozygous mutations in FGFR1, -2 and -3 and TWIST as well as microdeletions of TWIST in human craniosynostosis syndromes has highlighted these ..
  33. ncbi Fibroblast growth factor (FGF) receptor 1-IIIb is a naturally occurring functional receptor for FGFs that is preferentially expressed in the skin and the brain
    H D Beer
    Institute of Cell Biology, Swiss Federal Institute of Technology, CH 8093 Zurich, Switzerland
    J Biol Chem 275:16091-7. 2000
    Fibroblast growth factors (FGFs) transmit their signals through four transmembrane receptors that are designated FGFR1-4...
  34. ncbi Expression of members of the Fgf family and their receptors during midfacial development
    M Bachler
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030, Vienna, Austria
    Mech Dev 100:313-6. 2001
    ..5. In contrast to the restricted expression patterns of the ligands, FgfR1 and FgfR2 were broadly expressed in facial mesenchyme and ectoderm, respectively, indicating a wide competence of ..
  35. ncbi The mouse Fgfrl1 gene coding for a novel FGF receptor-like protein
    M Wiedemann
    M E Müller Institute, University of Bern, P O Box 30, CH 3010, Bern, Switzerland
    Biochim Biophys Acta 1520:247-50. 2001
    ..The gene for Fgfrl1 comprises six exons and is located on mouse chromosome 5 in close proximity to the Idua gene for L-iduronidase...
  36. ncbi FGF signaling regulates mesoderm cell fate specification and morphogenetic movement at the primitive streak
    B Ciruna
    Department of Molecular and Medical Genetics, University of Toronto, Ontario, Canada
    Dev Cell 1:37-49. 2001
    ..Here, we demonstrate that FGFR1 orchestrates the epithelial to mesenchymal transition and morphogenesis of mesoderm at the primitive streak by ..
  37. ncbi Generation of Fgfr1 conditional knockout mice
    Xiaoling Xu
    Genetics of Development and Disease Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genesis 32:85-6. 2002
  38. pmc Inducible dimerization of FGFR1: development of a mouse model to analyze progressive transformation of the mammary gland
    Bryan E Welm
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    J Cell Biol 157:703-14. 2002
    ..These data indicate that acute iFGFR1 signaling results in increased lateral budding of the mammary ductal epithelium, and that sustained activation induces alveolar hyperplasia and invasive lesions...
  39. ncbi FGFR1 is required for the development of the auditory sensory epithelium
    Ulla Pirvola
    Institute of Biotechnology, 00014 University of Helsinki, Helsinki, Finland
    Neuron 35:671-80. 2002
    ..Here we show that loss-of-function mutations in mouse fibroblast growth factor receptor 1 (Fgfr1) cause a dose-dependent disruption of the organ of Corti...
  40. pmc Fgfr1 regulates patterning of the pharyngeal region
    Nina Trokovic
    Institute of Biotechnology, Viikki Biocenter, 00014 University of Helsinki, Finland
    Genes Dev 17:141-53. 2003
    ..Mice homozygous for a hypomorphic allele of Fgfr1 have craniofacial defects, some of which appeared to result from a failure in the early development of the second ..
  41. ncbi Sef inhibits fibroblast growth factor signaling by inhibiting FGFR1 tyrosine phosphorylation and subsequent ERK activation
    Dmitry Kovalenko
    Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough 04074 7205, USA
    J Biol Chem 278:14087-91. 2003
    ..Here we show that like zebrafish Sef (zSef), mouse Sef (mSef) interacts with FGFR1 and that the cytoplasmic domain of mSef mediates this interaction...
  42. ncbi Fgf3 and Fgf10 are required for mouse otic placode induction
    Tracy J Wright
    Department of Human Genetics, University of Utah, Salt Lake City, UT 84112 5330, USA
    Development 130:3379-90. 2003
    ..Finally, examination of embryos carrying three out of the four mutant Fgf alleles revealed intermediate phenotypes, suggesting a quantitative requirement for FGF signalling in otic vesicle formation...
  43. ncbi Conditional activation of fibroblast growth factor receptor (FGFR) 1, but not FGFR2, in prostate cancer cells leads to increased osteopontin induction, extracellular signal-regulated kinase activation, and in vivo proliferation
    Kevin W Freeman
    Department of Immunology, Baylor College of Medicine, One Baylor Plaza M929, Houston, TX 77030, USA
    Cancer Res 63:6237-43. 2003
    ..We have used chemically induced dimerization (CID) to elucidate the individual contributions of FGFR1 and FGFR2 to tumor etiology...
  44. ncbi FGF17b and FGF18 have different midbrain regulatory properties from FGF8b or activated FGF receptors
    Aimin Liu
    Howard Hughes Medical Institute, Developmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Development 130:6175-85. 2003
    ..As Fgf17 and Fgf18 are co-expressed with Fgf8 in many tissues, our studies have broad implications for how these FGFs differentially control development...
  45. ncbi Skeletal development is regulated by fibroblast growth factor receptor 1 signalling dynamics
    Mohammad K Hajihosseini
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Development 131:325-35. 2004
    ..chromosome (BAC)-based transgenic system in which a hypermorphic mutation has been introduced into the murine Fgfr1 gene...
  46. ncbi Regulation of external genitalia development by concerted actions of FGF ligands and FGF receptors
    Yoshihiko Satoh
    Center for Animal Resources and Development, Graduate School of Molecular and Genomic Pharmacy, Kumamoto University, 860 0811 Kumamoto, Japan
    Anat Embryol (Berl) 208:479-86. 2004
    ..external genitalia development, we have analyzed the expression of FGF genes (Fgf8, 9, 10) and receptor genes (Fgfr1, r2IIIb, r2IIIc) in GT of mice...
  47. pmc HSF4 is required for normal cell growth and differentiation during mouse lens development
    Mitsuaki Fujimoto
    Department of Biochemistry and Molecular Biology, Yamaguchi University School of Medicine, Minami Kogushi 1 1 1, Ube 755 8505, Japan
    EMBO J 23:4297-306. 2004
    ....
  48. ncbi FRS2-dependent SRC activation is required for fibroblast growth factor receptor-induced phosphorylation of Sprouty and suppression of ERK activity
    Xuan Li
    CR UK Growth Factor Group, School of Biosciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK
    J Cell Sci 117:6007-17. 2004
    ..Phosphorylation of hSpry2 is required for hSpry2 to inhibit activation of the extracellular signal-regulated kinase pathway. These results show that recruitment of SRC to FRS2 leads to activation of signal attenuation pathways...
  49. ncbi Expression of Fgf receptors 1, 2, and 3 in the developing mid- and hindbrain of the mouse
    Alexandra A Blak
    GSF National Research Center for Environment and Health, Institute of Developmental Genetics, Neuherberg, Germany
    Dev Dyn 233:1023-30. 2005
    ..Studies of Fgfr expression in early vertebrate development have shown that Fgfr1 is expressed along the entire neural tube, whereas Fgfr2 and Fgfr3 expression has been shown to spare the tissue ..
  50. pmc Conditional knockdown of Fgfr2 in mice using Cre-LoxP induced RNA interference
    Xavier Coumoul
    Genetics of Development and Disease Branch, 10 9N105, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health Bethesda, Maryland, MD 20892, USA
    Nucleic Acids Res 33:e102. 2005
    ..This method provides a fast, yet efficient way to decipher gene functions in vivo in a tissue-specific manner...
  51. ncbi FGF8 is required for cell survival at distinct stages of nephrogenesis and for regulation of gene expression in nascent nephrons
    Uta Grieshammer
    Department of Anatomy and Program in Developmental Biology, School of Medicine, University of California at San Francisco, San Francisco, CA 94143 2711, USA
    Development 132:3847-57. 2005
    ..Thus, unlike other FGF family members, which regulate growth and branching morphogenesis of the collecting duct system, Fgf8 encodes a factor essential for gene regulation and cell survival at distinct steps in nephrogenesis...
  52. ncbi Context-specific requirements for Fgfr1 signaling through Frs2 and Frs3 during mouse development
    Renée V Hoch
    Program in Developmental Biology, Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Development 133:663-73. 2006
    b>Fibroblast growth factor receptor 1 (Fgfr1) plays pleiotropic roles during embryonic development, but the mechanisms by which this receptor signals in vivo have not previously been elucidated...
  53. pmc Fibroblast growth factor receptor 1 (Fgfr1) is not essential for lens fiber differentiation in mice
    Haotian Zhao
    Center for Human and Molecular Genetics, Columbus Children s Research Institute, Columbus, OH, USA
    Mol Vis 12:15-25. 2006
    The developing lens expresses at least three different FGF receptor genes (Fgfr1, Fgfr2, Fgfr3). Furthermore, FGFs have been shown to induce lens epithelial cells to differentiate into fiber cells both in vitro and in vivo...
  54. ncbi Ectopic activity of fibroblast growth factor receptor 1 in hepatocytes accelerates hepatocarcinogenesis by driving proliferation and vascular endothelial growth factor-induced angiogenesis
    Xinqiang Huang
    Center for Cancer Biology and Nutrition, Institute of Biosciences and Technology, Texas A and M University System Health Science Center, 2121 West Holcombe Boulevard, Houston, TX 77030, USA
    Cancer Res 66:1481-90. 2006
    ..Of the four FGF receptor (FGFR) tyrosine kinases, only FGFR4 is expressed in mature hepatocytes. Although FGFR1 is expressed by hepatic cell progenitors and adult nonparenchymal cells, ectopic expression is commonly observed ..
  55. ncbi FGF9 and SHH signaling coordinate lung growth and development through regulation of distinct mesenchymal domains
    Andrew C White
    Department of Molecular Biology and Pharmacology, Washington University Medical School, St Louis, MO 63110, USA
    Development 133:1507-17. 2006
    ....
  56. ncbi FGF signalling generates ventral telencephalic cells independently of SHH
    Grigoriy Gutin
    Departments of Neuroscience and Molecular Genetics, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Bronx, NY 10461, USA
    Development 133:2937-46. 2006
    ..First, simultaneous deletion of Fgfr1 and Fgfr3 specifically in the telencephalon results in the loss of differentiated ventromedial cells; and second, ..
  57. pmc FGF2 posttranscriptionally down-regulates expression of SDF1 in bone marrow stromal cells through FGFR1 IIIc
    Takayuki Nakayama
    Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    Blood 109:1363-72. 2007
    ..Blocking experiments identified FGFR1 IIIc as the receptor mediating FGF2 inhibition of SDF-1 expression in bone marrow stromal cells...
  58. ncbi SOX3 activity during pharyngeal segmentation is required for craniofacial morphogenesis
    Karine Rizzoti
    Division of Developmental Genetics, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Development 134:3437-48. 2007
    ..We also show that Sox3 genetically interacts both with FgfR1 and with Sox2, another member of the Soxb1 family, to fulfil its function in the pharyngeal region...
  59. ncbi Deficiency in inhibitory cortical interneurons associates with hyperactivity in fibroblast growth factor receptor 1 mutant mice
    Karen Müller Smith
    Child Study Center, Yale University, New Haven, Connecticut 06520, USA
    Biol Psychiatry 63:953-62. 2008
    ..Motor hyperactivity due to hyper-dopaminergic neurotransmission in the basal ganglia is well characterized; much less is known about the role of the neocortex in controlling motor behavior...
  60. ncbi FGF signaling regulates mesenchymal differentiation and skeletal patterning along the limb bud proximodistal axis
    Kai Yu
    Department of Developmental Biology, Washington University School of Medicine, St Louis, MO 63110 USA
    Development 135:483-91. 2008
    ..fgf receptor 2 (Fgfr2) in the mouse AER to terminate all AER functions; for comparison, we inactivated both Fgfr1 and Fgfr2 in limb mesenchyme to block mesenchymal AER-FGF signaling...
  61. ncbi A beta-catenin gradient links the clock and wavefront systems in mouse embryo segmentation
    Alexander Aulehla
    Stowers Institute for Medical Research, Kansas City, MO 64110, USA
    Nat Cell Biol 10:186-93. 2008
    ..This gradient of nuclear beta-catenin defines the size of the oscillatory field and controls key aspects of PSM maturation and segment formation, emphasizing the central role of Wnt signalling in this process...
  62. doi Wnt11/Fgfr1b cross-talk modulates the fate of cells in palate development
    Jong Min Lee
    Department of Oral Biology, Research Center for Orofacial Hard Tissue Regeneration, Yonsei University, Seoul, Republic of Korea
    Dev Biol 314:341-50. 2008
    ..Wnt-11 overexpression and beads soaked in SU5402 (an Fgfr1 inhibitor) were employed in in vitro organ cultures...
  63. pmc Phosphorylation of fibroblast growth factor (FGF) receptor 1 at Ser777 by p38 mitogen-activated protein kinase regulates translocation of exogenous FGF1 to the cytosol and nucleus
    Vigdis Sørensen
    Centre for Cancer Biomedicine, Faculty Division Norwegian Radium Hospital, University of Oslo, Oslo, Norway
    Mol Cell Biol 28:4129-41. 2008
    ..The activity level of p38 MAPK was not found to affect endocytosis or intracellular sorting of FGF1/FGFR1. Instead, we found that p38 MAPK regulates FGF1 translocation by phosphorylation of FGFR1 at Ser777...
  64. pmc Fibroblast growth factor receptor signaling is essential for lens fiber cell differentiation
    Haotian Zhao
    Graduate Program in Molecular, Cellular and Developmental Biology, College of Biological Sciences, The Ohio State University, Columbus, OH 43210, USA
    Dev Biol 318:276-88. 2008
    ..Deletion of three FGF receptors (Fgfr1-3) early in lens development demonstrated that expression of only a single allele of Fgfr2 or Fgfr3 was sufficient ..
  65. pmc An FGF-WNT gene regulatory network controls lung mesenchyme development
    Yongjun Yin
    Department of Developmental Biology, Washington University School of Medicine, Campus Box 8103, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Dev Biol 319:426-36. 2008
    ..Together, both FGF and WNT signaling pathways function to sustain mesenchymal growth and coordinate epithelial morphogenesis during the pseudoglandular stage of lung development...
  66. pmc Role of fibroblast growth factor receptor 2 in kidney mesenchyme
    David Hains
    Center for Cell and Developmental Biology, The Research Institute at Nationwide Children s Hospital, Columbus, Ohio 43205, USA
    Pediatr Res 64:592-8. 2008
    ..Our goal was to determine whether conditional deletion of Fgfr1 or Fgfr2 alone resulted in multiple ureteric bud induction sites...
  67. pmc FGFR3 and FGFR4 do not mediate renal effects of FGF23
    Shiguang Liu
    Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    J Am Soc Nephrol 19:2342-50. 2008
    ..analysis of the mouse kidney revealed that the proximal tubule expresses FGF receptor 3 (FGFR3) but not FGFR1, FGFR2, or FGFR4...
  68. pmc Differential FGF ligands and FGF receptors expression pattern in frontal and parietal calvarial bones
    Natalina Quarto
    Children s Surgical Research Program, Department of Surgery, Stanford University School of Medicine, Stanford, Calif 94305 5148, USA
    Cells Tissues Organs 190:158-69. 2009
    ..Frontal bone also elaborated higher levels of Fgf receptor 1, 2 and 3 transcripts versus parietal bone. Taken together, these data suggest that the frontal bone is a domain with higher FGF-signaling competence than parietal bone...
  69. pmc FGF23 decreases renal NaPi-2a and NaPi-2c expression and induces hypophosphatemia in vivo predominantly via FGF receptor 1
    Jyothsna Gattineni
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9063, USA
    Am J Physiol Renal Physiol 297:F282-91. 2009
    ..In this study, we show that proximal tubules express FGFR1, -3, and -4 but not FGFR2 mRNA...
  70. pmc Expression patterns of FGF receptors in the developing mammalian cochlea
    Toshinori Hayashi
    Department of Biological Structure, Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, Washington 98109, USA
    Dev Dyn 239:1019-26. 2010
    ..There are four fibroblast growth factor receptors (FGFR1-4) and all four are expressed in the cochlea during development...
  71. pmc Differential fibroblast growth factor 8 (FGF8)-mediated autoregulation of its cognate receptors, Fgfr1 and Fgfr3, in neuronal cell lines
    Natasha N Mott
    Department of Cell and Molecular Physiology, Loyola University Chicago Stritch School of Medicine, Maywood, Illinois, United States of America
    PLoS ONE 5:e10143. 2010
    ..We tested whether FGF8 could autoregulate two of its cognate receptors, Fgfr1 and Fgfr3, in three murine cell lines with different lineages: fibroblast-derived cells (3T3 cells), neuronal ..
  72. pmc Fgfr2 is required for the development of the medial prefrontal cortex and its connections with limbic circuits
    Hanna E Stevens
    Child Study Center, Yale University, New Haven, Connecticut 06520, USA
    J Neurosci 30:5590-602. 2010
    ..fibroblast growth factor receptors (FGFRs) in cortical development, we conditionally inactivated Fgfr2 or both Fgfr1 and Fgfr2 [Fgfr2 conditional knock-out (cKO) or double knock-out mice, respectively] in radial glial cells of the ..
  73. pmc Fibroblast growth factor receptor signaling dramatically accelerates tumorigenesis and enhances oncoprotein translation in the mouse mammary tumor virus-Wnt-1 mouse model of breast cancer
    Adam C Pond
    Program in Cell and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Cancer Res 70:4868-79. 2010
    ..Wnt/beta-catenin target genes but instead showed a translational gene signature that also correlated with elevated FGFR1 and FGFR2 in human breast cancer data sets...
  74. pmc Sprouty genes prevent excessive FGF signalling in multiple cell types throughout development of the cerebellum
    Tian Yu
    Department of Craniofacial Development, King s College London, London, UK
    Development 138:2957-68. 2011
    ..A reduction in Fgfr1 dosage during development rescued these defects, confirming that the abnormalities are due to excess FGF ..
  75. pmc FGF signaling expands embryonic cortical surface area by regulating Notch-dependent neurogenesis
    Brian G Rash
    Yale Child Study Center, Yale University, New Haven, Connecticut 06520, USA
    J Neurosci 31:15604-17. 2011
    ....
  76. pmc Differentiation of the lateral compartment of the cochlea requires a temporally restricted FGF20 signal
    Sung Ho Huh
    Department of Developmental Biology, Washington University School of Medicine, St Louis, Missouri, USA
    PLoS Biol 10:e1001231. 2012
    ..The viability and hearing loss in Fgf20 knockout mice suggest that FGF20 may also be a deafness-associated gene in humans...
  77. pmc Impaired motor coordination and disrupted cerebellar architecture in Fgfr1 and Fgfr2 double knockout mice
    Karen Müller Smith
    Child Study Center, Yale University, 230 South Frontage Rd, New Haven, CT 06520, USA
    Brain Res 1460:12-24. 2012
    ..We show that Fgfr1 and Fgfr2 double knockouts (FGFR DKO) generated by Cre-mediated recombination driven by the human GFAP promoter (..
  78. pmc Antibody-mediated activation of FGFR1 induces FGF23 production and hypophosphatemia
    Ai Luen Wu
    Department of Molecular Biology, Genentech, Inc, South San Francisco, California, United States of America
    PLoS ONE 8:e57322. 2013
    ..Here we report that pharmacological activation of FGFR1 with monoclonal anti-FGFR1 antibodies (R1MAb) in adult mice is sufficient to cause an elevation in serum FGF23 and ..
  79. ncbi Chimeric analysis of fibroblast growth factor receptor-1 (Fgfr1) function: a role for FGFR1 in morphogenetic movement through the primitive streak
    B G Ciruna
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Development 124:2829-41. 1997
    ..In the mouse, FGF receptor-1 (FGFR1) is expressed in an appropriate spatial and temporal manner to be orchestrating these functions...
  80. ncbi Murine fibroblast growth factor receptor 1alpha isoforms mediate node regression and are essential for posterior mesoderm development
    X Xu
    National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, 20892, USA
    Dev Biol 208:293-306. 1999
    Alternative splicing in the fibroblast growth factor receptor 1 (Fgfr1) locus generates a variety of splicing isoforms, including FGFR1alpha isoforms, which contain three immunoglobulin-like loops in the extracellular domain of the ..
  81. ncbi Liver specification and early morphogenesis
    K S Zaret
    Cell and Developmental Biology Program, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA
    Mech Dev 92:83-8. 2000
    ..The initial stages of hepatogenesis are therefore beginning to be understood, and serve as a paradigm for the development of other tissues from the endoderm...
  82. ncbi Fibroblast growth factor receptor 1-IIIb is dispensable for skin morphogenesis and wound healing
    Hongbing Zhang
    Five Prime Therapeutics Inc, South San Francisco, CA, USA
    Eur J Cell Biol 83:3-11. 2004
    ..A poorly characterized splice variant is FGFR1-IIIb, recently found to be a functional FGF receptor predominantly expressed in the skin...
  83. pmc Sprouty genes control diastema tooth development via bidirectional antagonism of epithelial-mesenchymal FGF signaling
    Ophir D Klein
    Department of Anatomy and Program in Developmental Biology, School of Medicine, University of California, San Francisco, San Francisco, California 94143, USA
    Dev Cell 11:181-90. 2006
    ....
  84. ncbi Distinct roles of fibroblast growth factor receptor 1 and 2 in regulating cell survival and epithelial-mesenchymal transition
    Wa Xian
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Mol Endocrinol 21:987-1000. 2007
    Two related receptor tyrosine kinases (RTKs), fibroblast growth factor receptor 1 and 2 (FGFR1 and FGFR2), exert distinct effects during carcinogenesis...
  85. ncbi The initiation and propagation of Hes7 oscillation are cooperatively regulated by Fgf and notch signaling in the somite segmentation clock
    Yasutaka Niwa
    Institute for Virus Research, Kyoto University, Kyoto 606 8507, Japan
    Dev Cell 13:298-304. 2007
    ..We thus propose that Hes7 oscillation is initiated by Fgf signaling and propagated/maintained anteriorly by Notch signaling...
  86. pmc Fibroblast growth factor 8 signaling through fibroblast growth factor receptor 1 is required for the emergence of gonadotropin-releasing hormone neurons
    Wilson C J Chung
    Department of Integrative Physiology and Center for Neuroscience, University of Colorado, Boulder, Colorado 80309 0354, USA
    Endocrinology 149:4997-5003. 2008
    ..Mutations in both fibroblast growth factor receptor (Fgfr1) and Fgf8 have been shown to cause Kallmann syndrome, a disease characterized by hypogonadotropic hypogonadism and ..
  87. ncbi A truncated form of fibroblast growth factor receptor 1 inhibits signal transduction by multiple types of fibroblast growth factor receptor
    H Ueno
    Department of Medicine, University of California, San Francisco 94143 0724
    J Biol Chem 267:1470-6. 1992
    A truncated form of the type 1 fibroblast growth factor receptor (FGFR1) lacking most of its cytoplasmic domain was tested for its ability to inhibit signal transduction by each of three different wild-type FGFRs (FGFR1, 2, and 3)...
  88. ncbi Fgf9 signaling regulates inner ear morphogenesis through epithelial-mesenchymal interactions
    Ulla Pirvola
    Institute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland
    Dev Biol 273:350-60. 2004
    ..and cartilage stages, Fgf9 is expressed in specific nonsensory domains of the otic epithelium and its receptors, Fgfr1(IIIc) and Fgfr2(IIIc), widely in the surrounding mesenchyme...
  89. pmc Opposite phenotypes of hypomorphic and Y766 phosphorylation site mutations reveal a function for Fgfr1 in anteroposterior patterning of mouse embryos
    J Partanen
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto M5G 1X5, Canada
    Genes Dev 12:2332-44. 1998
    ..To dissect the functions of fibroblast growth factor receptor-1 (FGFR1) during mouse gastrulation as well as to gain insights into its possible roles during later embryonic development, ..
  90. ncbi Expression of the fibroblast growth factor receptor FGFR-1/flg during gastrulation and segmentation in the mouse embryo
    T P Yamaguchi
    Department of Molecular and Medical Genetics, University of Toronto, Ontario, Canada
    Dev Biol 152:75-88. 1992
    ..FGFR-1 may also play significant roles in the formation of neural ectoderm and the early events that establish compartments within the developing somites...
  91. pmc Receptor for acidic fibroblast growth factor is related to the tyrosine kinase encoded by the fms-like gene (FLG)
    M Ruta
    Rorer Biotechnology, Inc, King of Prussia, PA 19406
    Proc Natl Acad Sci U S A 86:8722-6. 1989
    ..endothelial cell cDNA library encoding a putative tyrosine kinase; we have designated this gene the fms-like gene (FLG)...
  92. ncbi Expression of fibroblast growth factor receptors (FGFR1, FGFR2, FGFR3) in the developing head and face
    T A Wilke
    Department of Oral Health Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, Canada
    Dev Dyn 210:41-52. 1997
    ..have analyzed the competency of head mesenchyme to respond to FGFs via expression of the high affinity receptors FGFR1, 2, and 3...
  93. ncbi Craniosynostosis: genes and mechanisms
    A O Wilkie
    Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK
    Hum Mol Genet 6:1647-56. 1997
    ..Mutations of the MSX2, FGFR1, FGFR2, FGFR3 and TWIST genes yield new insights, both into normal and abnormal cranial suture biogenesis and into ..
  94. ncbi The murine gene, Traube, is essential for the growth of preimplantation embryos
    T Thomas
    Department of Molecular Cell Biology, Max Planck Institute of Biophysical Chemistry, Am Fassberg 11, Goettingen, 37077, Germany
    Dev Biol 227:324-42. 2000
    ..This paucity of ribosomes together with the localization of TRB to the nucleoli, the site of ribosome synthesis, suggests that TRB is involved in the synthesis of ribosomes...
  95. ncbi FGF signaling is required for pulmonary homeostasis following hyperoxia
    Isamu Hokuto
    Cincinnati Children s Hospital Medical Center, Div of Pulmonary Biology, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
    Am J Physiol Lung Cell Mol Physiol 286:L580-7. 2004
    ..FGF signaling is required for maintenance of surfactant homeostasis and lung function during hyperoxia in vivo, mediated, at least in part, by its role in the maintenance of SP-B expression...
  96. ncbi CNTF/LIF/gp130 receptor complex signaling maintains a VZ precursor differentiation gradient in the developing ventral forebrain
    Christopher Gregg
    Genes and Development Research Group, Hotchkiss Brain Institute, University of Calgary Faculty of Medicine, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1, Canada
    Development 132:565-78. 2005
    ..These results demonstrate a novel region-specific role for CNTF/LIF/gp130 signaling in the development of the germinal layers of the embryonic telencephalon...
  97. ncbi The homeoprotein engrailed 1 has pleiotropic functions in calvarial intramembranous bone formation and remodeling
    Ron A Deckelbaum
    Department of Cell Biology, New York University School of Medicine, MSB room 614, 550 1st Avenue, New York, NY 10016, USA
    Development 133:63-74. 2006
    ..In summary, this study identifies EN1 as a novel modulator of calvarial osteoblast differentiation and proliferation, processes that must be exquisitely balanced to ensure proper skull vault formation...
  98. pmc NMR structure of the first Ig module of mouse FGFR1
    Vladislav V Kiselyov
    Protein Laboratory, Institute of Molecular Pathology, Copenhagen DK 2200, Denmark
    Protein Sci 15:1512-5. 2006
    ..We describe here the NMR structure of the Ig1 module of mouse FGFR1. The three-dimensional fold of the module belongs to the intermediate Ig subgroup and can be described as a beta-..
  99. ncbi Glypicans are differentially expressed during patterning and neurogenesis of early mouse brain
    Guillaume Luxardi
    IBDML CNRS UMR 6216, INSERM UMR623, Campus de Luminy, Case 907, 13288 Marseille Cedex 09, France
    Biochem Biophys Res Commun 352:55-60. 2007
    ..The novel expression sites of glypicans shown here contribute to the identification of signalling molecules involved in brain patterning...
  100. ncbi Ucma--A novel secreted factor represents a highly specific marker for distal chondrocytes
    Andreas Tagariello
    Institute of Human Genetics, University Hospital Erlangen, Schwabachanlage 10, D 91054 Erlangen, Germany
    Matrix Biol 27:3-11. 2008
    ..The present data strongly suggest an important function of Ucma in the early phase of chondrocyte differentiation...
  101. ncbi Fibroblast growth factor-2 in hyperplastic pituitaries of D2R knockout female mice
    Carolina Cristina
    Instituto de Biologia y Medicina Experimental, CONICET, V Obligado 2490, 1428, Buenos Aires, Argentina
    Am J Physiol Endocrinol Metab 293:E1341-51. 2007
    ..Our objective was to study the expression of the mitogen fibroblast growth factor (FGF2) and its receptor, FGFR1, comparatively in pituitaries from KO and wild-type (WT) female mice...

Research Grants2

  1. Peptide Regulators of Angiogenesis
    Michael Simons; Fiscal Year: 2005
    ....
  2. PROTEOMIC MAPPING OF MYELIN AND ITS MEMBRANE SUBDOMAINS
    Rashmi Bansal; Fiscal Year: 2009
    ....