Fgfr1

Summary

Gene Symbol: Fgfr1
Description: fibroblast growth factor receptor 1
Alias: AW208770, Eask, FGFR-I, FLG, Fgfr-1, Flt-2, Hspy, MFR, bFGF-R-1, c-fgr, fibroblast growth factor receptor 1, basic fibroblast growth factor receptor 1, proto-oncogene c-Fgr
Species: mouse
Products:     Fgfr1

Top Publications

  1. Jin Y, Pasumarthi K, Bock M, Lytras A, Kardami E, Cattini P. Cloning and expression of fibroblast growth factor receptor-1 isoforms in the mouse heart: evidence for isoform switching during heart development. J Mol Cell Cardiol. 1994;26:1449-59 pubmed
    ..The bFGF receptor-1 FGFR1) exists in short and long isoforms due to alternate RNA splicing...
  2. Ogawa Y, Kurosu H, Yamamoto M, Nandi A, Rosenblatt K, Goetz R, et al. BetaKlotho is required for metabolic activity of fibroblast growth factor 21. Proc Natl Acad Sci U S A. 2007;104:7432-7 pubmed
    ..Importantly, administration of FGF21 into mice induces MAP kinase phosphorylation in white adipose tissue and not in tissues without betaKlotho expression. Thus, betaKlotho functions as a cofactor essential for FGF21 activity. ..
  3. Lin Y, Chen L, Lin C, Luo Y, Tsai R, Wang F. Neuron-derived FGF9 is essential for scaffold formation of Bergmann radial fibers and migration of granule neurons in the cerebellum. Dev Biol. 2009;329:44-54 pubmed publisher
    ..This work demonstrates that granule neurons secrete FGF9 to control formation of the Bergmann fiber scaffold, which in turn, guides their own inward migration and maturation of Purkinje cells. ..
  4. Hains D, Sims Lucas S, Kish K, Saha M, McHugh K, Bates C. Role of fibroblast growth factor receptor 2 in kidney mesenchyme. Pediatr Res. 2008;64:592-8 pubmed publisher
    ..Our goal was to determine whether conditional deletion of Fgfr1 or Fgfr2 alone resulted in multiple ureteric bud induction sites...
  5. Zhao H, Yang T, Madakashira B, Thiels C, Bechtle C, Garcia C, et al. Fibroblast growth factor receptor signaling is essential for lens fiber cell differentiation. Dev Biol. 2008;318:276-88 pubmed publisher
    ..Deletion of three FGF receptors (Fgfr1-3) early in lens development demonstrated that expression of only a single allele of Fgfr2 or Fgfr3 was sufficient ..
  6. Tarkkonen K, Nilsson E, Kähkönen T, Dey J, Heikkilä J, Tuomela J, et al. Differential roles of fibroblast growth factor receptors (FGFR) 1, 2 and 3 in the regulation of S115 breast cancer cell growth. PLoS ONE. 2012;7:e49970 pubmed publisher
    ..Our aim was to clarify the roles of FGFR1-3 in breast cancer cell growth in vitro and in vivo...
  7. Rash B, Lim H, Breunig J, Vaccarino F. FGF signaling expands embryonic cortical surface area by regulating Notch-dependent neurogenesis. J Neurosci. 2011;31:15604-17 pubmed publisher
  8. Xu X, Li C, Takahashi K, Slavkin H, Shum L, Deng C. Murine fibroblast growth factor receptor 1alpha isoforms mediate node regression and are essential for posterior mesoderm development. Dev Biol. 1999;208:293-306 pubmed
    Alternative splicing in the fibroblast growth factor receptor 1 (Fgfr1) locus generates a variety of splicing isoforms, including FGFR1alpha isoforms, which contain three immunoglobulin-like loops in the extracellular domain of the ..
  9. Harada M, Murakami H, Okawa A, Okimoto N, Hiraoka S, Nakahara T, et al. FGF9 monomer-dimer equilibrium regulates extracellular matrix affinity and tissue diffusion. Nat Genet. 2009;41:289-98 pubmed publisher
    ..We propose a mechanism in which the range of FGF9 signaling in developing tissues is limited by its ability to homodimerize and its affinity for extracellular matrix heparan sulfate proteoglycans. ..
  10. Zhao M, Li D, Shimazu K, Zhou Y, Lu B, Deng C. Fibroblast growth factor receptor-1 is required for long-term potentiation, memory consolidation, and neurogenesis. Biol Psychiatry. 2007;62:381-90 pubmed
    ..Using conditional knockout mice that lack brain expression of FGFR1, a major receptor for FGF-2, we have investigated the role of adult neurogenesis in hippocampal synaptic ..

Detail Information

Publications62

  1. Jin Y, Pasumarthi K, Bock M, Lytras A, Kardami E, Cattini P. Cloning and expression of fibroblast growth factor receptor-1 isoforms in the mouse heart: evidence for isoform switching during heart development. J Mol Cell Cardiol. 1994;26:1449-59 pubmed
    ..The bFGF receptor-1 FGFR1) exists in short and long isoforms due to alternate RNA splicing...
  2. Ogawa Y, Kurosu H, Yamamoto M, Nandi A, Rosenblatt K, Goetz R, et al. BetaKlotho is required for metabolic activity of fibroblast growth factor 21. Proc Natl Acad Sci U S A. 2007;104:7432-7 pubmed
    ..Importantly, administration of FGF21 into mice induces MAP kinase phosphorylation in white adipose tissue and not in tissues without betaKlotho expression. Thus, betaKlotho functions as a cofactor essential for FGF21 activity. ..
  3. Lin Y, Chen L, Lin C, Luo Y, Tsai R, Wang F. Neuron-derived FGF9 is essential for scaffold formation of Bergmann radial fibers and migration of granule neurons in the cerebellum. Dev Biol. 2009;329:44-54 pubmed publisher
    ..This work demonstrates that granule neurons secrete FGF9 to control formation of the Bergmann fiber scaffold, which in turn, guides their own inward migration and maturation of Purkinje cells. ..
  4. Hains D, Sims Lucas S, Kish K, Saha M, McHugh K, Bates C. Role of fibroblast growth factor receptor 2 in kidney mesenchyme. Pediatr Res. 2008;64:592-8 pubmed publisher
    ..Our goal was to determine whether conditional deletion of Fgfr1 or Fgfr2 alone resulted in multiple ureteric bud induction sites...
  5. Zhao H, Yang T, Madakashira B, Thiels C, Bechtle C, Garcia C, et al. Fibroblast growth factor receptor signaling is essential for lens fiber cell differentiation. Dev Biol. 2008;318:276-88 pubmed publisher
    ..Deletion of three FGF receptors (Fgfr1-3) early in lens development demonstrated that expression of only a single allele of Fgfr2 or Fgfr3 was sufficient ..
  6. Tarkkonen K, Nilsson E, Kähkönen T, Dey J, Heikkilä J, Tuomela J, et al. Differential roles of fibroblast growth factor receptors (FGFR) 1, 2 and 3 in the regulation of S115 breast cancer cell growth. PLoS ONE. 2012;7:e49970 pubmed publisher
    ..Our aim was to clarify the roles of FGFR1-3 in breast cancer cell growth in vitro and in vivo...
  7. Rash B, Lim H, Breunig J, Vaccarino F. FGF signaling expands embryonic cortical surface area by regulating Notch-dependent neurogenesis. J Neurosci. 2011;31:15604-17 pubmed publisher
  8. Xu X, Li C, Takahashi K, Slavkin H, Shum L, Deng C. Murine fibroblast growth factor receptor 1alpha isoforms mediate node regression and are essential for posterior mesoderm development. Dev Biol. 1999;208:293-306 pubmed
    Alternative splicing in the fibroblast growth factor receptor 1 (Fgfr1) locus generates a variety of splicing isoforms, including FGFR1alpha isoforms, which contain three immunoglobulin-like loops in the extracellular domain of the ..
  9. Harada M, Murakami H, Okawa A, Okimoto N, Hiraoka S, Nakahara T, et al. FGF9 monomer-dimer equilibrium regulates extracellular matrix affinity and tissue diffusion. Nat Genet. 2009;41:289-98 pubmed publisher
    ..We propose a mechanism in which the range of FGF9 signaling in developing tissues is limited by its ability to homodimerize and its affinity for extracellular matrix heparan sulfate proteoglycans. ..
  10. Zhao M, Li D, Shimazu K, Zhou Y, Lu B, Deng C. Fibroblast growth factor receptor-1 is required for long-term potentiation, memory consolidation, and neurogenesis. Biol Psychiatry. 2007;62:381-90 pubmed
    ..Using conditional knockout mice that lack brain expression of FGFR1, a major receptor for FGF-2, we have investigated the role of adult neurogenesis in hippocampal synaptic ..
  11. Kovalenko D, Yang X, Nadeau R, Harkins L, Friesel R. Sef inhibits fibroblast growth factor signaling by inhibiting FGFR1 tyrosine phosphorylation and subsequent ERK activation. J Biol Chem. 2003;278:14087-91 pubmed
    ..Here we show that like zebrafish Sef (zSef), mouse Sef (mSef) interacts with FGFR1 and that the cytoplasmic domain of mSef mediates this interaction...
  12. Quarto N, Behr B, Li S, Longaker M. Differential FGF ligands and FGF receptors expression pattern in frontal and parietal calvarial bones. Cells Tissues Organs. 2009;190:158-69 pubmed publisher
    ..Frontal bone also elaborated higher levels of Fgf receptor 1, 2 and 3 transcripts versus parietal bone. Taken together, these data suggest that the frontal bone is a domain with higher FGF-signaling competence than parietal bone...
  13. Hayashi T, Ray C, Bermingham McDonogh O. Fgf20 is required for sensory epithelial specification in the developing cochlea. J Neurosci. 2008;28:5991-9 pubmed publisher
    Tissue-specific deletion of Fgfr1 results in severe defects in the development of both hair cells and support cells (Pirvola et al., 2002)...
  14. Werner S, Duan D, de Vries C, Peters K, Johnson D, Williams L. Differential splicing in the extracellular region of fibroblast growth factor receptor 1 generates receptor variants with different ligand-binding specificities. Mol Cell Biol. 1992;12:82-8 pubmed
    We have cloned a genomic region of the murine fibroblast growth factor (FGF) receptor 1 (FGFR1) gene that includes three alternative exons for the third immunoglobulinlike domain in the extracellular region of the receptor...
  15. Huang X, Yu C, Jin C, Kobayashi M, Bowles C, Wang F, et al. Ectopic activity of fibroblast growth factor receptor 1 in hepatocytes accelerates hepatocarcinogenesis by driving proliferation and vascular endothelial growth factor-induced angiogenesis. Cancer Res. 2006;66:1481-90 pubmed
    ..Of the four FGF receptor (FGFR) tyrosine kinases, only FGFR4 is expressed in mature hepatocytes. Although FGFR1 is expressed by hepatic cell progenitors and adult nonparenchymal cells, ectopic expression is commonly observed ..
  16. Liu A, Li J, Bromleigh C, Lao Z, Niswander L, Joyner A. FGF17b and FGF18 have different midbrain regulatory properties from FGF8b or activated FGF receptors. Development. 2003;130:6175-85 pubmed
    ..As Fgf17 and Fgf18 are co-expressed with Fgf8 in many tissues, our studies have broad implications for how these FGFs differentially control development. ..
  17. Trokovic N, Trokovic R, Mai P, Partanen J. Fgfr1 regulates patterning of the pharyngeal region. Genes Dev. 2003;17:141-53 pubmed
    ..Mice homozygous for a hypomorphic allele of Fgfr1 have craniofacial defects, some of which appeared to result from a failure in the early development of the second ..
  18. Deng C, Wynshaw Boris A, Shen M, Daugherty C, Ornitz D, Leder P. Murine FGFR-1 is required for early postimplantation growth and axial organization. Genes Dev. 1994;8:3045-57 pubmed
    We have explored the role of fibroblast growth factor receptor 1 (FGFR-1) in early embryonic development using three experimental systems: genetically deficient mice, in vitro blastocyst culture, and FGFR-1-deficient embryonic stem cells...
  19. Rizzoti K, Lovell Badge R. SOX3 activity during pharyngeal segmentation is required for craniofacial morphogenesis. Development. 2007;134:3437-48 pubmed
    ..We also show that Sox3 genetically interacts both with FgfR1 and with Sox2, another member of the Soxb1 family, to fulfil its function in the pharyngeal region...
  20. Xian W, Schwertfeger K, Rosen J. Distinct roles of fibroblast growth factor receptor 1 and 2 in regulating cell survival and epithelial-mesenchymal transition. Mol Endocrinol. 2007;21:987-1000 pubmed
    Two related receptor tyrosine kinases (RTKs), fibroblast growth factor receptor 1 and 2 (FGFR1 and FGFR2), exert distinct effects during carcinogenesis...
  21. Partanen J, Schwartz L, Rossant J. Opposite phenotypes of hypomorphic and Y766 phosphorylation site mutations reveal a function for Fgfr1 in anteroposterior patterning of mouse embryos. Genes Dev. 1998;12:2332-44 pubmed
    ..To dissect the functions of fibroblast growth factor receptor-1 (FGFR1) during mouse gastrulation as well as to gain insights into its possible roles during later embryonic development, ..
  22. Li X, Brunton V, Burgar H, Wheldon L, Heath J. FRS2-dependent SRC activation is required for fibroblast growth factor receptor-induced phosphorylation of Sprouty and suppression of ERK activity. J Cell Sci. 2004;117:6007-17 pubmed
    ..Phosphorylation of hSpry2 is required for hSpry2 to inhibit activation of the extracellular signal-regulated kinase pathway. These results show that recruitment of SRC to FRS2 leads to activation of signal attenuation pathways. ..
  23. Hayashi T, Cunningham D, Bermingham McDonogh O. Loss of Fgfr3 leads to excess hair cell development in the mouse organ of Corti. Dev Dyn. 2007;236:525-33 pubmed
    ..At early stages of embryogenesis, Fgfr1, Fgfr2, and several FGFs are critical for both the induction of the otic vesicle and the initial development of ..
  24. Hayashi T, Ray C, Younkins C, Bermingham McDonogh O. Expression patterns of FGF receptors in the developing mammalian cochlea. Dev Dyn. 2010;239:1019-26 pubmed publisher
    ..There are four fibroblast growth factor receptors (FGFR1-4) and all four are expressed in the cochlea during development...
  25. Stevens H, Smith K, Maragnoli M, Fagel D, Borok E, Shanabrough M, et al. Fgfr2 is required for the development of the medial prefrontal cortex and its connections with limbic circuits. J Neurosci. 2010;30:5590-602 pubmed publisher
    ..fibroblast growth factor receptors (FGFRs) in cortical development, we conditionally inactivated Fgfr2 or both Fgfr1 and Fgfr2 [Fgfr2 conditional knock-out (cKO) or double knock-out mice, respectively] in radial glial cells of the ..
  26. Wu A, Feng B, Chen M, Kolumam G, Zavala Solorio J, Wyatt S, et al. Antibody-mediated activation of FGFR1 induces FGF23 production and hypophosphatemia. PLoS ONE. 2013;8:e57322 pubmed publisher
    ..Here we report that pharmacological activation of FGFR1 with monoclonal anti-FGFR1 antibodies (R1MAb) in adult mice is sufficient to cause an elevation in serum FGF23 and ..
  27. White A, Xu J, Yin Y, Smith C, Schmid G, Ornitz D. FGF9 and SHH signaling coordinate lung growth and development through regulation of distinct mesenchymal domains. Development. 2006;133:1507-17 pubmed
  28. Li C, Scott D, Hatch E, Tian X, Mansour S. Dusp6 (Mkp3) is a negative feedback regulator of FGF-stimulated ERK signaling during mouse development. Development. 2007;134:167-76 pubmed
  29. Jung J, Zheng M, Goldfarb M, Zaret K. Initiation of mammalian liver development from endoderm by fibroblast growth factors. Science. 1999;284:1998-2003 pubmed
    ..Thus, different FGF signals appear to initiate distinct phases of liver development during mammalian organogenesis. ..
  30. Welm B, Freeman K, Chen M, Contreras A, Spencer D, Rosen J. Inducible dimerization of FGFR1: development of a mouse model to analyze progressive transformation of the mammary gland. J Cell Biol. 2002;157:703-14 pubmed
    ..These data indicate that acute iFGFR1 signaling results in increased lateral budding of the mammary ductal epithelium, and that sustained activation induces alveolar hyperplasia and invasive lesions. ..
  31. Grieshammer U, Cebrian C, Ilagan R, Meyers E, Herzlinger D, Martin G. FGF8 is required for cell survival at distinct stages of nephrogenesis and for regulation of gene expression in nascent nephrons. Development. 2005;132:3847-57 pubmed
    ..Thus, unlike other FGF family members, which regulate growth and branching morphogenesis of the collecting duct system, Fgf8 encodes a factor essential for gene regulation and cell survival at distinct steps in nephrogenesis. ..
  32. Yu T, Yaguchi Y, Echevarria D, Martinez S, Basson M. Sprouty genes prevent excessive FGF signalling in multiple cell types throughout development of the cerebellum. Development. 2011;138:2957-68 pubmed publisher
    ..A reduction in Fgfr1 dosage during development rescued these defects, confirming that the abnormalities are due to excess FGF ..
  33. Nakayama T, Mutsuga N, Tosato G. FGF2 posttranscriptionally down-regulates expression of SDF1 in bone marrow stromal cells through FGFR1 IIIc. Blood. 2007;109:1363-72 pubmed
    ..Blocking experiments identified FGFR1 IIIc as the receptor mediating FGF2 inhibition of SDF-1 expression in bone marrow stromal cells...
  34. Zhou Y, Xu X, Chen L, Li C, Brodie S, Deng C. A Pro250Arg substitution in mouse Fgfr1 causes increased expression of Cbfa1 and premature fusion of calvarial sutures. Hum Mol Genet. 2000;9:2001-8 pubmed
    ..that is caused by a proline-->arginine substitution at amino acid 252 (Pro252Arg) in fibroblast growth factor receptor 1 (FGFR1)...
  35. Yin Y, White A, Huh S, Hilton M, Kanazawa H, Long F, et al. An FGF-WNT gene regulatory network controls lung mesenchyme development. Dev Biol. 2008;319:426-36 pubmed publisher
    ..Together, both FGF and WNT signaling pathways function to sustain mesenchymal growth and coordinate epithelial morphogenesis during the pseudoglandular stage of lung development. ..
  36. Müller Smith K, Fagel D, Stevens H, Rabenstein R, Maragnoli M, Ohkubo Y, et al. Deficiency in inhibitory cortical interneurons associates with hyperactivity in fibroblast growth factor receptor 1 mutant mice. Biol Psychiatry. 2008;63:953-62 pubmed
    ..motor, associative, and spatial learning were examined in mice with conditional null mutations of fibroblast growth factor receptor 1 (Fgfr1) restricted to telencephalic neural precursors (Fgfr1(f/f;hGfapCre))...
  37. Zhao H, Yang Y, Partanen J, Ciruna B, Rossant J, Robinson M. Fibroblast growth factor receptor 1 (Fgfr1) is not essential for lens fiber differentiation in mice. Mol Vis. 2006;12:15-25 pubmed
    The developing lens expresses at least three different FGF receptor genes (Fgfr1, Fgfr2, Fgfr3). Furthermore, FGFs have been shown to induce lens epithelial cells to differentiate into fiber cells both in vitro and in vivo...
  38. Coumoul X, Shukla V, Li C, Wang R, Deng C. Conditional knockdown of Fgfr2 in mice using Cre-LoxP induced RNA interference. Nucleic Acids Res. 2005;33:e102 pubmed
    ..This method provides a fast, yet efficient way to decipher gene functions in vivo in a tissue-specific manner. ..
  39. Raballo R, Rhee J, Lyn Cook R, Leckman J, Schwartz M, Vaccarino F. Basic fibroblast growth factor (Fgf2) is necessary for cell proliferation and neurogenesis in the developing cerebral cortex. J Neurosci. 2000;20:5012-23 pubmed
    ..We suggest that Fgf2 is required for the generation of a specific class of cortical neurons arising from the dorsal PVE. ..
  40. Kettunen P, Karavanova I, Thesleff I. Responsiveness of developing dental tissues to fibroblast growth factors: expression of splicing alternatives of FGFR1, -2, -3, and of FGFR4; and stimulation of cell proliferation by FGF-2, -4, -8, and -9. Dev Genet. 1998;22:374-85 pubmed
    ..The expression patterns of FGFR1 -2, and -3 were completely different, and the two splicing variants of FGFR1 and 2 exhibited different expression ..
  41. Sørensen V, Zhen Y, Zakrzewska M, Haugsten E, Walchli S, Nilsen T, et al. Phosphorylation of fibroblast growth factor (FGF) receptor 1 at Ser777 by p38 mitogen-activated protein kinase regulates translocation of exogenous FGF1 to the cytosol and nucleus. Mol Cell Biol. 2008;28:4129-41 pubmed publisher
    ..The activity level of p38 MAPK was not found to affect endocytosis or intracellular sorting of FGF1/FGFR1. Instead, we found that p38 MAPK regulates FGF1 translocation by phosphorylation of FGFR1 at Ser777...
  42. SMITH K, Ohkubo Y, Maragnoli M, Rasin M, Schwartz M, Sestan N, et al. Midline radial glia translocation and corpus callosum formation require FGF signaling. Nat Neurosci. 2006;9:787-97 pubmed
    ..These cells require the fibroblast growth factor receptor 1 (Fgfr1) gene for their precocious somal translocation to the dorsal midline, as demonstrated by ..
  43. Paek H, Gutin G, Hebert J. FGF signaling is strictly required to maintain early telencephalic precursor cell survival. Development. 2009;136:2457-65 pubmed publisher
  44. Aulehla A, Wiegraebe W, Baubet V, Wahl M, Deng C, Taketo M, et al. A beta-catenin gradient links the clock and wavefront systems in mouse embryo segmentation. Nat Cell Biol. 2008;10:186-93 pubmed
    ..This gradient of nuclear beta-catenin defines the size of the oscillatory field and controls key aspects of PSM maturation and segment formation, emphasizing the central role of Wnt signalling in this process. ..
  45. Ozawa K, Uruno T, Miyakawa K, Seo M, Imamura T. Expression of the fibroblast growth factor family and their receptor family genes during mouse brain development. Brain Res Mol Brain Res. 1996;41:279-88 pubmed
    ..e., proliferation and migration of neuronal progenitor cells, neuron and glia differentiation, neurite extensions, and synapse formations. ..
  46. Urakawa I, Yamazaki Y, Shimada T, Iijima K, Hasegawa H, Okawa K, et al. Klotho converts canonical FGF receptor into a specific receptor for FGF23. Nature. 2006;444:770-4 pubmed
    ..to be incapable of intracellular signalling, we searched for other components of the FGF23 receptor and found FGFR1(IIIc), which was directly converted by Klotho into the FGF23 receptor...
  47. Pond A, Herschkowitz J, Schwertfeger K, Welm B, Zhang Y, York B, et al. Fibroblast growth factor receptor signaling dramatically accelerates tumorigenesis and enhances oncoprotein translation in the mouse mammary tumor virus-Wnt-1 mouse model of breast cancer. Cancer Res. 2010;70:4868-79 pubmed publisher
    ..Wnt/beta-catenin target genes but instead showed a translational gene signature that also correlated with elevated FGFR1 and FGFR2 in human breast cancer data sets...
  48. Wang Y, Becker D. Antisense targeting of basic fibroblast growth factor and fibroblast growth factor receptor-1 in human melanomas blocks intratumoral angiogenesis and tumor growth. Nat Med. 1997;3:887-93 pubmed
    ..Thus, inhibition of bFGF/FGFR-1-mediated signaling may open a new avenue for the treatment of advanced-stage melanomas. ..
  49. Robinson M, MacMillan Crow L, Thompson J, Overbeek P. Expression of a truncated FGF receptor results in defective lens development in transgenic mice. Development. 1995;121:3959-67 pubmed
    ..in normal lens development was evaluated by lens-specific synthesis of a kinase-deficient FGF receptor type I (FGFR1) in transgenic mice...
  50. Ciruna B, Rossant J. FGF signaling regulates mesoderm cell fate specification and morphogenetic movement at the primitive streak. Dev Cell. 2001;1:37-49 pubmed
    ..Here, we demonstrate that FGFR1 orchestrates the epithelial to mesenchymal transition and morphogenesis of mesoderm at the primitive streak by ..
  51. Wright T, Mansour S. Fgf3 and Fgf10 are required for mouse otic placode induction. Development. 2003;130:3379-90 pubmed
    ..Finally, examination of embryos carrying three out of the four mutant Fgf alleles revealed intermediate phenotypes, suggesting a quantitative requirement for FGF signalling in otic vesicle formation. ..
  52. Sala F, Curtis J, Veltmaat J, del Moral P, Le L, Fairbanks T, et al. Fibroblast growth factor 10 is required for survival and proliferation but not differentiation of intestinal epithelial progenitor cells during murine colon development. Dev Biol. 2006;299:373-85 pubmed
    ..Our work unravels for the first time the pivotal role of FGF10 in the survival and proliferation of the colonic epithelium, biological activities which are essential for colonic crypt formation. ..
  53. Gattineni J, Bates C, Twombley K, Dwarakanath V, Robinson M, Goetz R, et al. FGF23 decreases renal NaPi-2a and NaPi-2c expression and induces hypophosphatemia in vivo predominantly via FGF receptor 1. Am J Physiol Renal Physiol. 2009;297:F282-91 pubmed publisher
    ..In this study, we show that proximal tubules express FGFR1, -3, and -4 but not FGFR2 mRNA...
  54. Johnson D, Iseki S, Wilkie A, Morriss Kay G. Expression patterns of Twist and Fgfr1, -2 and -3 in the developing mouse coronal suture suggest a key role for twist in suture initiation and biogenesis. Mech Dev. 2000;91:341-5 pubmed
    ..The identification of heterozygous mutations in FGFR1, -2 and -3 and TWIST as well as microdeletions of TWIST in human craniosynostosis syndromes has highlighted these ..
  55. Beer H, Vindevoghel L, Gait M, Revest J, Duan D, Mason I, et al. Fibroblast growth factor (FGF) receptor 1-IIIb is a naturally occurring functional receptor for FGFs that is preferentially expressed in the skin and the brain. J Biol Chem. 2000;275:16091-7 pubmed
    Fibroblast growth factors (FGFs) transmit their signals through four transmembrane receptors that are designated FGFR1-4...
  56. Niwa Y, Masamizu Y, Liu T, Nakayama R, Deng C, Kageyama R. The initiation and propagation of Hes7 oscillation are cooperatively regulated by Fgf and notch signaling in the somite segmentation clock. Dev Cell. 2007;13:298-304 pubmed
    ..We thus propose that Hes7 oscillation is initiated by Fgf signaling and propagated/maintained anteriorly by Notch signaling. ..
  57. Riuzzi F, Sorci G, Donato R. S100B protein regulates myoblast proliferation and differentiation by activating FGFR1 in a bFGF-dependent manner. J Cell Sci. 2011;124:2389-400 pubmed publisher
    ..that S100B increases and/or stabilizes the binding of basic fibroblast growth factor (bFGF) to bFGF receptor 1 (FGFR1) by interacting with bFGF, thereby enhancing FGFR1 activation and the mitogenic and anti-myogenic effects of FGFR1...
  58. Ohkubo Y, Uchida A, Shin D, Partanen J, Vaccarino F. Fibroblast growth factor receptor 1 is required for the proliferation of hippocampal progenitor cells and for hippocampal growth in mouse. J Neurosci. 2004;24:6057-69 pubmed
    b>Fibroblast growth factor receptor 1 (Fgfr1) is expressed at high levels by progenitor cells of the ventricular zone (VZ) within the hippocampal primordium...
  59. Blak A, Naserke T, Weisenhorn D, Prakash N, Partanen J, Wurst W. Expression of Fgf receptors 1, 2, and 3 in the developing mid- and hindbrain of the mouse. Dev Dyn. 2005;233:1023-30 pubmed
    ..Studies of Fgfr expression in early vertebrate development have shown that Fgfr1 is expressed along the entire neural tube, whereas Fgfr2 and Fgfr3 expression has been shown to spare the tissue ..
  60. Kitagaki J, Ueda Y, Chi X, Sharma N, Elder C, Truffer E, et al. FGF8 is essential for formation of the ductal system in the male reproductive tract. Development. 2011;138:5369-78 pubmed publisher
    ..These results demonstrate a multifocal requirement for FGF8 in establishing the male reproductive tract ducts and implicate Lhx1 signaling in tubule elongation. ..
  61. Zou L, Cao S, Kang N, Huebert R, Shah V. Fibronectin induces endothelial cell migration through ?1 integrin and Src-dependent phosphorylation of fibroblast growth factor receptor-1 at tyrosines 653/654 and 766. J Biol Chem. 2012;287:7190-202 pubmed publisher
    ..that the provisional matrix protein, fibronectin (FN), activates fibroblast growth factor (FGF) receptor-1 (FGFR1) independent of FGF ligand in liver endothelial cells...
  62. Müller Smith K, Williamson T, Schwartz M, Vaccarino F. Impaired motor coordination and disrupted cerebellar architecture in Fgfr1 and Fgfr2 double knockout mice. Brain Res. 2012;1460:12-24 pubmed publisher
    ..We show that Fgfr1 and Fgfr2 double knockouts (FGFR DKO) generated by Cre-mediated recombination driven by the human GFAP promoter (..