Gene Symbol: Fgf22
Description: fibroblast growth factor 22
Alias: 2210414E06Rik, FGF-22, fibroblast growth factor 22
Species: mouse
Products:     Fgf22

Top Publications

  1. Nakatake Y, Hoshikawa M, Asaki T, Kassai Y, Itoh N. Identification of a novel fibroblast growth factor, FGF-22, preferentially expressed in the inner root sheath of the hair follicle. Biochim Biophys Acta. 2001;1517:460-3 pubmed
    ..By in situ hybridization, FGF-22 mRNA in the skin was found to be preferentially expressed in the inner root sheath of the hair follicle. Therefore, FGF-22 is expected to be a unique FGF that plays a role in hair development. ..
  2. Beyer T, Werner S, Dickson C, Grose R. Fibroblast growth factor 22 and its potential role during skin development and repair. Exp Cell Res. 2003;287:228-36 pubmed
    ..5 embryos, as well as in adult skin and keratinocytes of the hyperthickened wound epithelium. This expression pattern suggests a potential role for FGF-22 in cutaneous development and repair. ..
  3. Wright T, Hatch E, Karabagli H, Karabagli P, Schoenwolf G, Mansour S. Expression of mouse fibroblast growth factor and fibroblast growth factor receptor genes during early inner ear development. Dev Dyn. 2003;228:267-72 pubmed
    ..Fgf16 was expressed in the posterior otic cup and vesicle, suggesting roles in otic cell fate decisions and/or axis formation. ..
  4. Beer H, Bittner M, Niklaus G, Munding C, Max N, Goppelt A, et al. The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair. Oncogene. 2005;24:5269-77 pubmed
  5. Zhong W, Wang Q, Sun T, Wang F, Liu J, Leach R, et al. FGF ligand family mRNA expression profile for mouse preimplantation embryos, early gestation human placenta, and mouse trophoblast stem cells. Mol Reprod Dev. 2006;73:540-50 pubmed
    ..RT-PCR was done for developmentally important FGF subfamilies, FGF10/FGF22 and FGF8/FGF17/FGF18 as well as FGF11. FGF4 and FGF18 are detected at highest levels by RT-PCR and microarrays...
  6. Umemori H, Linhoff M, Ornitz D, Sanes J. FGF22 and its close relatives are presynaptic organizing molecules in the mammalian brain. Cell. 2004;118:257-70 pubmed
    ..as an assay, we purified putative target-derived presynaptic organizing molecules from mouse brain and identified FGF22 as a major active species...
  7. Singh R, Su J, Brooks J, Terauchi A, Umemori H, Fox M. Fibroblast growth factor 22 contributes to the development of retinal nerve terminals in the dorsal lateral geniculate nucleus. Front Mol Neurosci. 2012;4:61 pubmed publisher
    ..One candidate "organizing" molecule enriched in perinatal dLGN was FGF22, a secreted cue that induces the formation of excitatory nerve terminals in muscle, hippocampus, and cerebellum...
  8. Terauchi A, Johnson Venkatesh E, Toth A, Javed D, Sutton M, Umemori H. Distinct FGFs promote differentiation of excitatory and inhibitory synapses. Nature. 2010;465:783-7 pubmed publisher
    ..Here we show that two members of the fibroblast growth factor (FGF) family, FGF22 and FGF7, promote the organization of excitatory and inhibitory presynaptic terminals, respectively, as target-..
  9. Zhang X, Ibrahimi O, Olsen S, Umemori H, Mohammadi M, Ornitz D. Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family. J Biol Chem. 2006;281:15694-700 pubmed
    ..This study completes the mitogenesis-based comparison of receptor specificity of the entire FGF family under standard conditions and should help in interpreting and predicting in vivo biological activity. ..

More Information


  1. Jarosz M, Robbez Masson L, Chioni A, Cross B, Rosewell I, Grose R. Fibroblast growth factor 22 is not essential for skin development and repair but plays a role in tumorigenesis. PLoS ONE. 2012;7:e39436 pubmed publisher
    ..Of the 22 mammalian FGFs, FGF22, a member of the FGF7/10/22 subfamily, has been shown to have a clear role in synaptogenesis, but its roles in ..
  2. Zhao F, Franco H, Rodriguez K, Brown P, Tsai M, Tsai S, et al. Elimination of the male reproductive tract in the female embryo is promoted by COUP-TFII in mice. Science. 2017;357:717-720 pubmed publisher
    ..We thus suggest that elimination of Wolffian ducts in female embryos is actively promoted by COUP-TFII, which suppresses a mesenchyme-epithelium cross-talk responsible for Wolffian duct maintenance. ..
  3. Terauchi A, Johnson Venkatesh E, Bullock B, Lehtinen M, Umemori H. Retrograde fibroblast growth factor 22 (FGF22) signaling regulates insulin-like growth factor 2 (IGF2) expression for activity-dependent synapse stabilization in the mammalian brain. elife. 2016;5: pubmed publisher
    ..Here we show that fibroblast growth factor 22 (FGF22), a target-derived presynaptic organizer in the mouse hippocampus, induces the expression of ..
  4. Asada M, Shinomiya M, Suzuki M, Honda E, Sugimoto R, Ikekita M, et al. Glycosaminoglycan affinity of the complete fibroblast growth factor family. Biochim Biophys Acta. 2009;1790:40-8 pubmed publisher
    ..This is noteworthy, as the differential interactions of these growth factors with GAGs may be key determinants of their specific biological activities. ..
  5. WILLIAMS A, Yee P, Smith M, Murphy G, Umemori H. Deletion of fibroblast growth factor 22 (FGF22) causes a depression-like phenotype in adult mice. Behav Brain Res. 2016;307:11-7 pubmed publisher
    ..b>Fibroblast growth factor 22 (FGF22) is important for specifying excitatory synapses during development, including in the ..
  6. Pasaoglu T, Schikorski T. Presynaptic size of associational/commissural CA3 synapses is controlled by fibroblast growth factor 22 in adult mice. Hippocampus. 2016;26:151-60 pubmed publisher
    ..structure of excitatory synapses in the stratum radiatum of the CA3d area in adult wild type (WT) and fibroblast growth factor 22 knock-out (FGF22KO) mice by using serial 3D electron microscopy...
  7. Terauchi A, Timmons K, Kikuma K, Pechmann Y, Kneussel M, Umemori H. Selective synaptic targeting of the excitatory and inhibitory presynaptic organizers FGF22 and FGF7. J Cell Sci. 2015;128:281-92 pubmed publisher
    Specific formation of excitatory and inhibitory synapses is crucial for proper functioning of the brain. Fibroblast growth factor 22 (FGF22) and FGF7 are postsynaptic-cell-derived presynaptic organizers necessary for excitatory and ..
  8. Terauchi A, Gavin E, Wilson J, Umemori H. Selective Inactivation of Fibroblast Growth Factor 22 (FGF22) in CA3 Pyramidal Neurons Impairs Local Synaptogenesis and Affective Behavior Without Affecting Dentate Neurogenesis. Front Synaptic Neurosci. 2017;9:17 pubmed publisher
    ..We have previously identified that fibroblast growth factor 22 (FGF22) is critical for excitatory synapse formation in several brain regions including the hippocampus...
  9. Miyake A, Itoh N. Fgf22 regulated by Fgf3/Fgf8 signaling is required for zebrafish midbrain development. Biol Open. 2013;2:515-24 pubmed publisher
    ..Here, we identified zebrafish fgf22 predominantly expressed in the posterior midbrain and anterior midbrain-hindbrain boundary (MHB) primordia during ..
  10. Speer A, Al Alam D, Sala F, Ford H, Bellusci S, Grikscheit T. Fibroblast growth factor 10-fibroblast growth factor receptor 2b mediated signaling is not required for adult glandular stomach homeostasis. PLoS ONE. 2012;7:e49127 pubmed publisher
    ..stomach expressed Fgf10, its receptors, Fgfr1b and Fgfr2b, and most of the other FGFR2b ligands (Fgf1, Fgf7, Fgf22) except for Fgf3 and Fgf20...
  11. Li S, Hang L, Ma Y. FGF22 protects hearing function from gentamycin ototoxicity by maintaining ribbon synapse number. Hear Res. 2016;332:39-45 pubmed publisher
    ..However, ototoxic damage of ribbon synapses is not understood clearly. Roles of fibroblast growth factor 22 (FGF22) on synapse formation were explored under gentamycin ototoxicity...
  12. Du W, Prochazka J, Prochazkova M, Klein O. Expression of FGFs during early mouse tongue development. Gene Expr Patterns. 2016;20:81-7 pubmed publisher
    ..Our results indicate that FGF signaling regulates tongue development at multiple stages. ..
  13. Garcia C, Huang J, Madakashira B, Liu Y, Rajagopal R, Dattilo L, et al. The function of FGF signaling in the lens placode. Dev Biol. 2011;351:176-85 pubmed publisher
    ..Since the expression of proteins required for lens formation was not altered in the knockout placode cells, we can conclude that FGF signaling from the optic vesicle is not required for lens induction. ..
  14. Al Alam D, Danopoulos S, Schall K, Sala F, Almohazey D, Fernandez G, et al. Fibroblast growth factor 10 alters the balance between goblet and Paneth cells in the adult mouse small intestine. Am J Physiol Gastrointest Liver Physiol. 2015;308:G678-90 pubmed publisher
    ..Further studies are needed to determine the mechanism by which Fgf10 alters cell differentiation in the small intestine. ..
  15. Jacobi A, Loy K, Schmalz A, Hellsten M, Umemori H, Kerschensteiner M, et al. FGF22 signaling regulates synapse formation during post-injury remodeling of the spinal cord. EMBO J. 2015;34:1231-43 pubmed publisher
    ..Here, we identify FGF22 as a key regulator of circuit remodeling in the injured spinal cord...
  16. Takase H, Itoh T, Ino S, Wang T, Koji T, Akira S, et al. FGF7 is a functional niche signal required for stimulation of adult liver progenitor cells that support liver regeneration. Genes Dev. 2013;27:169-81 pubmed publisher
    ..These findings provide new insights into the cellular and molecular basis for LPC regulation and identify FGF7 as a potential therapeutic target for liver diseases. ..
  17. Umemori H, Sanes J. Signal regulatory proteins (SIRPS) are secreted presynaptic organizing molecules. J Biol Chem. 2008;283:34053-61 pubmed publisher
    ..The effects of SIRP-alpha are distinct from those of another presynaptic organizer, FGF22: the two proteins induced vesicle clusters of different sizes, differed in their ability to promote neurite ..