Gene Symbol: Fgf20
Description: fibroblast growth factor 20
Alias: fibroblast growth factor 20, FGF-20
Species: mouse
Products:     Fgf20

Top Publications

  1. Hayashi T, Ray C, Bermingham McDonogh O. Fgf20 is required for sensory epithelial specification in the developing cochlea. J Neurosci. 2008;28:5991-9 pubmed publisher
    ..We also show that a specific FGF, FGF20, is the likely ligand for FGFR1 at this sensory specification phase of cochlear development; Fgf20 is expressed at ..
  2. Barak H, Huh S, Chen S, Jeanpierre C, Martinovic J, Parisot M, et al. FGF9 and FGF20 maintain the stemness of nephron progenitors in mice and man. Dev Cell. 2012;22:1191-207 pubmed publisher
    ..Here we provide evidence that Fgf20 and Fgf9, expressed in the niche, and Fgf9, secreted from the adjacent ureteric bud, are necessary and sufficient ..
  3. Al Alam D, Danopoulos S, Schall K, Sala F, Almohazey D, Fernandez G, et al. Fibroblast growth factor 10 alters the balance between goblet and Paneth cells in the adult mouse small intestine. Am J Physiol Gastrointest Liver Physiol. 2015;308:G678-90 pubmed publisher
    ..Further studies are needed to determine the mechanism by which Fgf10 alters cell differentiation in the small intestine. ..
  4. Speer A, Al Alam D, Sala F, Ford H, Bellusci S, Grikscheit T. Fibroblast growth factor 10-fibroblast growth factor receptor 2b mediated signaling is not required for adult glandular stomach homeostasis. PLoS ONE. 2012;7:e49127 pubmed publisher
    ..its receptors, Fgfr1b and Fgfr2b, and most of the other FGFR2b ligands (Fgf1, Fgf7, Fgf22) except for Fgf3 and Fgf20. Fgf10 expression was mesenchymal whereas FGFR1 and FGFR2 expression were mostly epithelial...
  5. Zhang Y, Li S, Yuan L, Tian Y, Weidenfeld J, Yang J, et al. Foxp1 coordinates cardiomyocyte proliferation through both cell-autonomous and nonautonomous mechanisms. Genes Dev. 2010;24:1746-57 pubmed publisher
    ..Endocardial loss of Foxp1 results in decreased Fgf3/Fgf16/Fgf17/Fgf20 expression in the heart, leading to reduced cardiomyocyte proliferation...
  6. Hajihosseini M, Heath J. Expression patterns of fibroblast growth factors-18 and -20 in mouse embryos is suggestive of novel roles in calvarial and limb development. Mech Dev. 2002;113:79-83 pubmed
  7. Mansour S, Li C, Urness L. Genetic rescue of Muenke syndrome model hearing loss reveals prolonged FGF-dependent plasticity in cochlear supporting cell fates. Genes Dev. 2013;27:2320-31 pubmed publisher
    ..This property might be exploited for the regulation of sensory cell regeneration from support cells. ..
  8. Tateya T, Imayoshi I, Tateya I, Hamaguchi K, Torii H, Ito J, et al. Hedgehog signaling regulates prosensory cell properties during the basal-to-apical wave of hair cell differentiation in the mammalian cochlea. Development. 2013;140:3848-57 pubmed publisher
  9. Osuala K, Baker C, Nguyen H, Martinez C, Weinshenker D, Ebert S. Physiological and genomic consequences of adrenergic deficiency during embryonic/fetal development in mice: impact on retinoic acid metabolism. Physiol Genomics. 2012;44:934-47 pubmed publisher

More Information


  1. Lee J, Yu Q, Shin J, Sebzda E, Bertozzi C, Chen M, et al. Klf2 is an essential regulator of vascular hemodynamic forces in vivo. Dev Cell. 2006;11:845-57 pubmed
    ..These findings identify Klf2 as an essential hemodynamic regulator in vivo and suggest that hemodynamic regulation in response to fluid shear stress is required for cardiovascular development and function. ..
  2. Häärä O, Harjunmaa E, Lindfors P, Huh S, Fliniaux I, Aberg T, et al. Ectodysplasin regulates activator-inhibitor balance in murine tooth development through Fgf20 signaling. Development. 2012;139:3189-99 pubmed publisher
    ..Here, we have analyzed a signaling network involving ectodysplasin (Eda) and fibroblast growth factor 20 (Fgf20) that subtly affects tooth morphogenesis...
  3. Huh S, Warchol M, Ornitz D. Cochlear progenitor number is controlled through mesenchymal FGF receptor signaling. elife. 2015;4: pubmed publisher
    ..we show that Fibroblast Growth Factors (FGF) 9 and 20, which are expressed in the non-sensory (Fgf9) and sensory (Fgf20) epithelium during otic development, regulate the number of cochlear progenitors...
  4. Lavine K, Yu K, White A, Zhang X, Smith C, Partanen J, et al. Endocardial and epicardial derived FGF signals regulate myocardial proliferation and differentiation in vivo. Dev Cell. 2005;8:85-95 pubmed
    ..Here, we show that Fgf9, Fgf16, and Fgf20 are expressed in the endocardium and epicardium and that RA can induce epicardial expression of Fgf9...
  5. van der Walt J, Noureddine M, Kittappa R, Hauser M, Scott W, McKay R, et al. Fibroblast growth factor 20 polymorphisms and haplotypes strongly influence risk of Parkinson disease. Am J Hum Genet. 2004;74:1121-7 pubmed
    ..Current research supports the involvement of fibroblast growth factor (FGF20) in the survival of dopaminergic cells...
  6. Xiao Y, Thoresen D, Miao L, Williams J, Wang C, ATIT R, et al. A Cascade of Wnt, Eda, and Shh Signaling Is Essential for Touch Dome Merkel Cell Development. PLoS Genet. 2016;12:e1006150 pubmed publisher
    ..Moreover, Merkel cells formed in Fgf20 mutant skin where primary hair formation was defective but Shh production was preserved...
  7. Munnamalai V, Hayashi T, Bermingham McDonogh O. Notch prosensory effects in the Mammalian cochlea are partially mediated by Fgf20. J Neurosci. 2012;32:12876-84 pubmed publisher
    ..Immunoblocking with Fgf20 antibody in vitro produced a similar phenotype...
  8. Chen S, Brunskill E, Potter S, Dexheimer P, Salomonis N, Aronow B, et al. Intrinsic Age-Dependent Changes and Cell-Cell Contacts Regulate Nephron Progenitor Lifespan. Dev Cell. 2015;35:49-62 pubmed publisher
    ..Age-dependent elevation in mTor and reduction in Fgf20 could contribute to increased exit rates...
  9. Song R, Preston G, Kidd L, Bushnell D, Sims Lucas S, Bates C, et al. Prorenin receptor is critical for nephron progenitors. Dev Biol. 2016;409:382-91 pubmed publisher
    ..Collectively, these findings demonstrate a cell-autonomous requirement for the PRR within nephron progenitors for progenitor maintenance, progression of nephrogenesis, normal kidney development and function. ..
  10. Wright T, Hatch E, Karabagli H, Karabagli P, Schoenwolf G, Mansour S. Expression of mouse fibroblast growth factor and fibroblast growth factor receptor genes during early inner ear development. Dev Dyn. 2003;228:267-72 pubmed
    ..Fgf16 was expressed in the posterior otic cup and vesicle, suggesting roles in otic cell fate decisions and/or axis formation. ..
  11. Huh S, Närhi K, Lindfors P, Häärä O, Yang L, Ornitz D, et al. Fgf20 governs formation of primary and secondary dermal condensations in developing hair follicles. Genes Dev. 2013;27:450-8 pubmed publisher
    ..Here, we show that fibroblast growth factor 20 (Fgf20) is expressed in hair placodes and is induced by and functions downstream from epithelial ..
  12. Takase H, Itoh T, Ino S, Wang T, Koji T, Akira S, et al. FGF7 is a functional niche signal required for stimulation of adult liver progenitor cells that support liver regeneration. Genes Dev. 2013;27:169-81 pubmed publisher
    ..These findings provide new insights into the cellular and molecular basis for LPC regulation and identify FGF7 as a potential therapeutic target for liver diseases. ..
  13. Huh S, Jones J, Warchol M, Ornitz D. Differentiation of the lateral compartment of the cochlea requires a temporally restricted FGF20 signal. PLoS Biol. 2012;10:e1001231 pubmed publisher
    ..Here we report that fibroblast growth factor 20 (FGF20) is required for differentiation of cells in the lateral cochlear compartment (outer hair and ..
  14. Levy R, Mott R, Iraqi F, Gabet Y. Collaborative cross mice in a genetic association study reveal new candidate genes for bone microarchitecture. BMC Genomics. 2015;16:1013 pubmed publisher
    ..Th), Rb1, and Cpb2 (with Conn.D). Other candidate genes strongly suggested by our analyses are Sgcz, Fgf20 (associated with Tb.N), and Chd2 (with Tb.Th)...
  15. Reid B, Yang H, Melvin V, Taketo M, Williams T. Ectodermal Wnt/?-catenin signaling shapes the mouse face. Dev Biol. 2011;349:261-9 pubmed publisher
  16. Du W, Prochazka J, Prochazkova M, Klein O. Expression of FGFs during early mouse tongue development. Gene Expr Patterns. 2016;20:81-7 pubmed publisher
    ..Our results indicate that FGF signaling regulates tongue development at multiple stages. ..
  17. Hotta Y, Sasaki S, Konishi M, Kinoshita H, Kuwahara K, Nakao K, et al. Fgf16 is required for cardiomyocyte proliferation in the mouse embryonic heart. Dev Dyn. 2008;237:2947-54 pubmed publisher
    ..The embryonic heart phenotype is similar to that of the Fgf9 knockout heart, indicating Fgf9 and Fgf16 to synergistically act as growth factors for embryonic cardiomyocytes. ..
  18. Ahtiainen L, Uski I, Thesleff I, Mikkola M. Early epithelial signaling center governs tooth budding morphogenesis. J Cell Biol. 2016;214:753-67 pubmed publisher
    ..These data functionally link the signaling center size to organ size and imply that the early signaling center is a prerequisite for budding morphogenesis. ..