Gene Symbol: Fgf2
Description: fibroblast growth factor 2
Alias: Fgf-2, Fgfb, bFGF, fibroblast growth factor 2, HBGF-2, basic fibroblast growth factor, heparin-binding growth factor 2
Species: mouse
Products:     Fgf2

Top Publications

  1. Dono R, Texido G, Dussel R, Ehmke H, Zeller R. Impaired cerebral cortex development and blood pressure regulation in FGF-2-deficient mice. EMBO J. 1998;17:4213-25 pubmed
    ..The observed autonomic dysfunction in FGF-2-deficient adult mice uncovers more general roles in neural development and function. ..
  2. Garmy Susini B, Delmas E, Gourdy P, Zhou M, Bossard C, Bugler B, et al. Role of fibroblast growth factor-2 isoforms in the effect of estradiol on endothelial cell migration and proliferation. Circ Res. 2004;94:1301-9 pubmed
    Both 17beta-estradiol (E2) and fibroblast growth factor-2 (FGF2) stimulate angiogenesis and endothelial cell migration and proliferation...
  3. Zheng W, Nowakowski R, Vaccarino F. Fibroblast growth factor 2 is required for maintaining the neural stem cell pool in the mouse brain subventricular zone. Dev Neurosci. 2004;26:181-96 pubmed
    Cells within the subventricular zone (SVZ) express basic Fgf (Fgf2) and Fgf receptor proteins...
  4. DeGeorge B, Rosenberg M, Eckstein V, Gao E, Herzog N, Katus H, et al. BMP-2 and FGF-2 synergistically facilitate adoption of a cardiac phenotype in somatic bone marrow c-kit+/Sca-1+ stem cells. Clin Transl Sci. 2008;1:116-25 pubmed publisher
  5. Yum H, Cho J, Miller M, Broide D. Allergen-induced coexpression of bFGF and TGF-?1 by macrophages in a mouse model of airway remodeling: bFGF induces macrophage TGF-?1 expression in vitro. Int Arch Allergy Immunol. 2011;155:12-22 pubmed publisher
    b>Basic fibroblast growth factor (bFGF) is a cytokine that is mitogenic for fibroblasts and smooth muscle and may play a role in airway remodeling in asthma...
  6. Muenke M, Schell U. Fibroblast-growth-factor receptor mutations in human skeletal disorders. Trends Genet. 1995;11:308-13 pubmed
    ..Comparison of these specific mutations with the resulting phenotypes is now providing new insight into the role of these receptors in normal and abnormal bone development. ..
  7. Korada S, Zheng W, Basilico C, Schwartz M, Vaccarino F. Fibroblast growth factor 2 is necessary for the growth of glutamate projection neurons in the anterior neocortex. J Neurosci. 2002;22:863-75 pubmed
    b>Basic fibroblast growth factor (Fgf2) is required for the generation of founder cells within the dorsal pseudostratified ventricular epithelium, which will generate the cerebral cortex, but the ganglionic eminences are not affected...
  8. Liao S, Porter D, Scott A, Newman G, Doetschman T, Schultz J. The cardioprotective effect of the low molecular weight isoform of fibroblast growth factor-2: the role of JNK signaling. J Mol Cell Cardiol. 2007;42:106-20 pubmed
    Our laboratory showed that overexpression of fibroblast growth factor-2 (FGF2) protected the heart against ischemia-reperfusion injury...
  9. Camozzi M, Rusnati M, Bugatti A, Bottazzi B, Mantovani A, Bastone A, et al. Identification of an antiangiogenic FGF2-binding site in the N terminus of the soluble pattern recognition receptor PTX3. J Biol Chem. 2006;281:22605-13 pubmed
    ..PTX3 binds fibroblast growth factor-2 (FGF2), inhibiting its pro-angiogenic and pro-restenotic activity...

More Information


  1. Dirks R, Potter S, Griep A. Novel fibroblast growth factor 2 transcripts are expressed in mouse embryos. Biochem Biophys Res Commun. 2001;287:900-9 pubmed
    We have discovered two new exons in the mouse fibroblast growth factor 2 (FGF-2 or bFGF) gene that can be alternatively spliced to the second coding exon of the gene...
  2. Gonzalez Herrera I, Prado Lourenco L, Pileur F, Conte C, Morin A, Cabon F, et al. Testosterone regulates FGF-2 expression during testis maturation by an IRES-dependent translational mechanism. FASEB J. 2006;20:476-8 pubmed
    Spermatogenesis is a complex process involving cell proliferation, differentiation, and apoptosis. Fibroblast growth factor 2 (FGF-2) is involved in testicular function, but its role in spermatogenesis has not been fully documented...
  3. Garcia C, Huang J, Madakashira B, Liu Y, Rajagopal R, Dattilo L, et al. The function of FGF signaling in the lens placode. Dev Biol. 2011;351:176-85 pubmed publisher
    ..Since the expression of proteins required for lens formation was not altered in the knockout placode cells, we can conclude that FGF signaling from the optic vesicle is not required for lens induction. ..
  4. Xiao L, Sobue T, Esliger A, Kronenberg M, Coffin J, Doetschman T, et al. Disruption of the Fgf2 gene activates the adipogenic and suppresses the osteogenic program in mesenchymal marrow stromal stem cells. Bone. 2010;47:360-70 pubmed publisher
    Here we determine the Fibroblast Growth Factor-2 (FGF2) dependency of the time course of changes in bone mass in female mice...
  5. Hollnagel A, Oehlmann V, Heymer J, Ruther U, Nordheim A. Id genes are direct targets of bone morphogenetic protein induction in embryonic stem cells. J Biol Chem. 1999;274:19838-45 pubmed
    ..cells responded very selectively to stimulation by various mesoderm inducers (BMP2/4, activin A, and basic fibroblast growth factor)...
  6. Teshima Kondo S, Kondo K, Prado Lourenco L, Gonzalez Herrera I, Rokutan K, Bayard F, et al. Hyperglycemia upregulates translation of the fibroblast growth factor 2 mRNA in mouse aorta via internal ribosome entry site. FASEB J. 2004;18:1583-5 pubmed
    b>Fibroblast growth factor 2 (FGF-2) is normally synthesized at low levels but is elevated in various pathophysiological conditions including diabetes-associated vascular diseases...
  7. Reuss B, Dono R, Unsicker K. Functions of fibroblast growth factor (FGF)-2 and FGF-5 in astroglial differentiation and blood-brain barrier permeability: evidence from mouse mutants. J Neurosci. 2003;23:6404-12 pubmed
    ..The observed defect in astroglial differentiation is accompanied by a defect in BBB function arguing for an indirect or direct role of FGFs in the regulation of BBB permeability in vivo. ..
  8. Baron O, Ratzka A, Grothe C. Fibroblast growth factor 2 regulates adequate nigrostriatal pathway formation in mice. J Comp Neurol. 2012;520:3949-61 pubmed publisher
    b>Fibroblast growth factor 2 (FGF-2) is an important neurotrophic factor that promotes survival of adult mesencephalic dopaminergic (mDA) neurons and regulates their adequate development...
  9. Vaccarino F, Schwartz M, Raballo R, Nilsen J, Rhee J, Zhou M, et al. Changes in cerebral cortex size are governed by fibroblast growth factor during embryogenesis. Nat Neurosci. 1999;2:246-53 pubmed
    We show that fibroblast growth factor 2 (FGF2) and FGF receptors are transiently expressed by cells of the pseudostratified ventricular epithelium (PVE) during early neurogenesis...
  10. Li C, Hughes Fulford M. Fibroblast growth factor-2 is an immediate-early gene induced by mechanical stress in osteogenic cells. J Bone Miner Res. 2006;21:946-55 pubmed
    ..Here, we show that MS induced proliferation in both MC3T3-E1 and BMOp cells isolated from Fgf2(+/+) mice; Fgf2(-/-) BMOp cells required exogenous FGF-2 for a normal proliferation response...
  11. Byun M, Kim A, Hwang J, Kim K, Hwang E, Hong J. FGF2 stimulates osteogenic differentiation through ERK induced TAZ expression. Bone. 2014;58:72-80 pubmed publisher
    ..Within this family, FGF2 stimulates osteoblast differentiation though a mechanism that is largely unknown...
  12. du Cros D. Fibroblast growth factor influences the development and cycling of murine hair follicles. Dev Biol. 1993;156:444-53 pubmed
    The effects of basic fibroblast growth factor (bFGF) on the development of hair follicles in neonatal mouse skin were examined...
  13. Raballo R, Rhee J, Lyn Cook R, Leckman J, Schwartz M, Vaccarino F. Basic fibroblast growth factor (Fgf2) is necessary for cell proliferation and neurogenesis in the developing cerebral cortex. J Neurosci. 2000;20:5012-23 pubmed
    ..We have previously shown that the germline mutation of the basic fibroblast growth factor (Fgf2) gene results in a reduction in the number of cortical neurons in the adult...
  14. Quarto N, Behr B, Li S, Longaker M. Differential FGF ligands and FGF receptors expression pattern in frontal and parietal calvarial bones. Cells Tissues Organs. 2009;190:158-69 pubmed publisher
    ..Frontal bone also elaborated higher levels of Fgf receptor 1, 2 and 3 transcripts versus parietal bone. Taken together, these data suggest that the frontal bone is a domain with higher FGF-signaling competence than parietal bone...
  15. Li S, Quarto N, Longaker M. Dura mater-derived FGF-2 mediates mitogenic signaling in calvarial osteoblasts. Am J Physiol Cell Physiol. 2007;293:C1834-42 pubmed
  16. Timmer M, Cesnulevicius K, Winkler C, Kolb J, Lipokatic Takacs E, Jungnickel J, et al. Fibroblast growth factor (FGF)-2 and FGF receptor 3 are required for the development of the substantia nigra, and FGF-2 plays a crucial role for the rescue of dopaminergic neurons after 6-hydroxydopamine lesion. J Neurosci. 2007;27:459-71 pubmed
    b>Basic fibroblast growth factor (FGF-2) is involved in the development and maintenance of the nervous system. Exogenous administration of FGF-2 increased dopaminergic (DA) graft survival in different animal models of Parkinson's disease...
  17. Quarto N, Longaker M. FGF-2 inhibits osteogenesis in mouse adipose tissue-derived stromal cells and sustains their proliferative and osteogenic potential state. Tissue Eng. 2006;12:1405-18 pubmed
    ..These FGF-2 functional characteristics may assist with cell selection and enrichment for the purpose of bone tissue engineering. ..
  18. Montero A, Okada Y, Tomita M, Ito M, Tsurukami H, Nakamura T, et al. Disruption of the fibroblast growth factor-2 gene results in decreased bone mass and bone formation. J Clin Invest. 2000;105:1085-93 pubmed
    b>Basic fibroblast growth factor (FGF-2), an important modulator of cartilage and bone growth and differentiation, is expressed and regulated in osteoblastic cells...
  19. Sierra O, Cheng S, Loewy A, Charlton Kachigian N, Towler D. MINT, the Msx2 interacting nuclear matrix target, enhances Runx2-dependent activation of the osteocalcin fibroblast growth factor response element. J Biol Chem. 2004;279:32913-23 pubmed
    ..with endogenous Runx2 and FGFR2), MINT augments transcription driven by the OCFRE that is further enhanced by FGF2 treatment. OCFRE regulation can be reconstituted in the naïve CV1 fibroblast cell background...
  20. Zhou M, Sutliff R, Paul R, Lorenz J, Hoying J, Haudenschild C, et al. Fibroblast growth factor 2 control of vascular tone. Nat Med. 1998;4:201-7 pubmed
    ..Here we show that a well-known growth factor, FGF2, long thought to be involved in many developmental and homeostatic processes, including growth of the tissue layers ..
  21. Riuzzi F, Sorci G, Donato R. S100B protein regulates myoblast proliferation and differentiation by activating FGFR1 in a bFGF-dependent manner. J Cell Sci. 2011;124:2389-400 pubmed publisher
    ..Here, we show that S100B increases and/or stabilizes the binding of basic fibroblast growth factor (bFGF) to bFGF receptor 1 (FGFR1) by interacting with bFGF, thereby enhancing FGFR1 activation and the ..
  22. Bressan R, Melo F, Almeida P, Bittencourt D, Visoni S, Jeremias T, et al. EGF-FGF2 stimulates the proliferation and improves the neuronal commitment of mouse epidermal neural crest stem cells (EPI-NCSCs). Exp Cell Res. 2014;327:37-47 pubmed publisher
    ..Since the combination of epidermal growth factor (EGF) and fibroblast growth factor type 2 (FGF2) is mitogenic and promotes the neuronal commitment of various stem cell populations, we examined its effects in the ..
  23. McClellan K, Vanderluit J, Julian L, Andrusiak M, Dugal Tessier D, Park D, et al. The p107/E2F pathway regulates fibroblast growth factor 2 responsiveness in neural precursor cells. Mol Cell Biol. 2009;29:4701-13 pubmed publisher
    ..Here, we demonstrate that fibroblast growth factor 2 (FGF2) is aberrantly upregulated in the brains of animals lacking Rb family proteins and that the gene ..
  24. Wesche J, Małecki J, Wiedłocha A, Skjerpen C, Claus P, Olsnes S. FGF-1 and FGF-2 require the cytosolic chaperone Hsp90 for translocation into the cytosol and the cell nucleus. J Biol Chem. 2006;281:11405-12 pubmed
    ..The data indicate that the drugs block translocation from endosomes to the cytosol implying that Hsp90 is required for translocation of FGF-1 and FGF-2 across the endosomal membrane. ..
  25. Murillo M, Zelenay S, Nye E, Castellano E, Lassailly F, Stamp G, et al. RAS interaction with PI3K p110? is required for tumor-induced angiogenesis. J Clin Invest. 2014;124:3601-11 pubmed publisher
    ..Targeting the interaction of RAS with PI3K has the potential to impair tumor formation by altering the tumor-host relationship, in addition to previously described tumor cell-autonomous effects. ..
  26. Yang F, Liu Y, Tu J, Wan J, Zhang J, Wu B, et al. Activated astrocytes enhance the dopaminergic differentiation of stem cells and promote brain repair through bFGF. Nat Commun. 2014;5:5627 pubmed publisher
    ..expressing engineered channelrhodopsin variant (ChETA) can remarkably enhance the release of basic fibroblast growth factor (bFGF) and significantly promote the DA differentiation of human embryonic stem cells (hESCs) in vitro...
  27. Abraham J, Mergia A, Whang J, Tumolo A, Friedman J, Hjerrild K, et al. Nucleotide sequence of a bovine clone encoding the angiogenic protein, basic fibroblast growth factor. Science. 1986;233:545-8 pubmed
    ..Both growth factors seem to be synthesized with short amino-terminal extensions that are not found on the isolated forms for which the amino acid sequences have been determined. Neither basic nor acidic FGF has a classic signal peptide. ..
  28. Muglia L, Jenkins N, Gilbert D, Copeland N, Majzoub J. Expression of the mouse corticotropin-releasing hormone gene in vivo and targeted inactivation in embryonic stem cells. J Clin Invest. 1994;93:2066-72 pubmed
    ..Mice chimeric for each of two ES clones with an inactivated CRH allele are being used to generate animals with complete CRH deficiency. ..
  29. Kiprianova I, Schindowski K, Von Bohlen Und Halbach O, Krause S, Dono R, Schwaninger M, et al. Enlarged infarct volume and loss of BDNF mRNA induction following brain ischemia in mice lacking FGF-2. Exp Neurol. 2004;189:252-60 pubmed
    ..We have used mice with a null mutation of the fgf2 gene to explore the relevance of endogenous FGF-2 in brain ischemia...
  30. Fujimoto M, Izu H, Seki K, Fukuda K, Nishida T, Yamada S, et al. HSF4 is required for normal cell growth and differentiation during mouse lens development. EMBO J. 2004;23:4297-306 pubmed
  31. Li C, Guo H, Xu X, Weinberg W, Deng C. Fibroblast growth factor receptor 2 (Fgfr2) plays an important role in eyelid and skin formation and patterning. Dev Dyn. 2001;222:471-83 pubmed
    ..Notably, mutant skin remains thin with decreased hair density after transplantation to wild-type recipients. These data demonstrate an essential role of Fgfr2 in eyelid and skin formation and patterning. ..
  32. Sudheer S, Liu J, Marks M, Koch F, Anurin A, Scholze M, et al. Different Concentrations of FGF Ligands, FGF2 or FGF8 Determine Distinct States of WNT-Induced Presomitic Mesoderm. Stem Cells. 2016;34:1790-800 pubmed publisher
    ..Stem Cells 2016;34:1790-1800. ..
  33. Xie Q, McGreal R, Harris R, Gao C, Liu W, Reneker L, et al. Regulation of c-Maf and αA-Crystallin in Ocular Lens by Fibroblast Growth Factor Signaling. J Biol Chem. 2016;291:3947-58 pubmed publisher
    ..expression of αA-crystallin (Cryaa) through binding to its promoter and distal enhancer, DCR1, both activated by FGF2 in cell culture...
  34. Coffin J, Florkiewicz R, Neumann J, Mort Hopkins T, Dorn G, Lightfoot P, et al. Abnormal bone growth and selective translational regulation in basic fibroblast growth factor (FGF-2) transgenic mice. Mol Biol Cell. 1995;6:1861-73 pubmed
    b>Basic fibroblast growth factor (FGF-2) is a pleiotropic growth factor detected in many different cells and tissues. Normally synthesized at low levels, FGF-2 is elevated in various pathologies, most notably in cancer and injury repair...
  35. Hatch N, Nociti F, Swanson E, Bothwell M, Somerman M. FGF2 alters expression of the pyrophosphate/phosphate regulating proteins, PC-1, ANK and TNAP, in the calvarial osteoblastic cell line, MC3T3E1(C4). Connect Tissue Res. 2005;46:184-92 pubmed
    ..Subsequently, the effect of FGF2 treatment on expression of PC-1, ANK, and TNAP in the calvarial osteoblastic cell line, MC3T3E1(C4), was ..
  36. Kondo S, Yin D, Aoki T, Takahashi J, Morimura T, Takeuchi J. bcl-2 gene prevents apoptosis of basic fibroblast growth factor-deprived murine aortic endothelial cells. Exp Cell Res. 1994;213:428-32 pubmed
    Growth factors such as basic fibroblast growth factor (bFGF) have been found to promote the survival and proliferation of endothelial cells...
  37. Weltrowski A, da Silva Almeida M, Peschel D, Zhang K, Fischer S, Groth T. Mitogenic activity of sulfated chitosan and cellulose derivatives is related to protection of FGF-2 from proteolytic cleavage. Macromol Biosci. 2012;12:740-50 pubmed publisher
    ..Results indicate that the mitogenic activity of CHS and CS is due to protection of FGF-2 from proteolytic cleavage. ..
  38. Sabbieti M, Agas D, Xiao L, Marchetti L, Coffin J, Doetschman T, et al. Endogenous FGF-2 is critically important in PTH anabolic effects on bone. J Cell Physiol. 2009;219:143-51 pubmed publisher
    ..and fibroblast growth factor-2 (FGF-2) expression in osteoblasts and the anabolic response to PTH is reduced in Fgf2-/- mice...
  39. Zhang J, Chang J, Huang Y, Lin X, Luo Y, Schwartz R, et al. The FGF-BMP signaling axis regulates outflow tract valve primordium formation by promoting cushion neural crest cell differentiation. Circ Res. 2010;107:1209-19 pubmed publisher
    ..The results demonstrate a novel mechanism by which the FGF-BMP signaling axis regulates formation of OFT valve primordia by controlling smooth muscle differentiation of cushion NCCs. ..
  40. Anderson J, Mitchell C, McGeachie J, Grounds M. The time course of basic fibroblast growth factor expression in crush-injured skeletal muscles of SJL/J and BALB/c mice. Exp Cell Res. 1995;216:325-34 pubmed
    Staining for basic fibroblast growth factor (bFGF), a potent mitogen, was examined in muscle recovering from a crush injury and compared between two mouse strains with distinctly different capacities for muscle regeneration to determine ..
  41. Meo Burt P, Xiao L, DEALY C, Fisher M, Hurley M. FGF2 High Molecular Weight Isoforms Contribute to Osteoarthropathy in Male Mice. Endocrinology. 2016;157:4602-4614 pubmed
    ..b>Fibroblast growth factor 2 (FGF2) is a key regulatory growth factor in osteoarthritis...
  42. Griner J, Rogers C, Zhu M, Du M. Lysyl oxidase propeptide promotes adipogenesis through inhibition of FGF-2 signaling. Adipocyte. 2017;6:12-19 pubmed publisher
    ..Our data suggest that LOX-PP may serve as a bona fide therapeutic target for regulating adipogenesis and adipose tissue development. ..
  43. Han J, Hwang A, Nam D, Kim S, Choi H, Lim J, et al. ERK5 regulates basic fibroblast growth factor-induced type 1 plasminogen activator inhibitor expression and cell proliferation in lung fibroblasts. Life Sci. 2015;135:1-8 pubmed publisher
    b>bFGF is a potent mitogen of cells associated with fibrosis...
  44. Mailankot M, Howell S, Nagaraj R. Kynurenine inhibits fibroblast growth factor 2-mediated expression of crystallins and MIP26 in lens epithelial cells. Biochim Biophys Acta. 2010;1802:609-20 pubmed publisher
    Fibroblast growth factor-2 (FGF2)-mediated signaling plays an important role in fiber cell differentiation in eye lens...
  45. Polnaszek N, Kwabi Addo B, Peterson L, Ozen M, Greenberg N, Ortega S, et al. Fibroblast growth factor 2 promotes tumor progression in an autochthonous mouse model of prostate cancer. Cancer Res. 2003;63:5754-60 pubmed
    Fibroblast growth factor (FGF) 2 (or basic FGF) is expressed at increased levels in human prostate cancer. FGF2 can promote cell motility and proliferation, increase tumor angiogenesis, and inhibit apoptosis, all of which play an ..
  46. Sturm J, Keese M, Zhang H, Bönninghoff R, Magdeburg R, Vajkoczy P, et al. Liver regeneration in FGF-2-deficient mice: VEGF acts as potential functional substitute for FGF-2. Liver Int. 2004;24:161-8 pubmed
    ..Liver regeneration dynamics in FGF-2-(-/-) mice were comparable with controls, potentially due to a functional substitution of FGF-2 by VEGF. ..
  47. Rousseau B, Larrieu Lahargue F, Bikfalvi A, Javerzat S. Involvement of fibroblast growth factors in choroidal angiogenesis and retinal vascularization. Exp Eye Res. 2003;77:147-56 pubmed
    ..Both the failure in hyaloid regression and the intense angiogenic invasion of endothelial cells into the retina may serve as a model for some related human ocular pathologies. ..
  48. Du W, Prochazka J, Prochazkova M, Klein O. Expression of FGFs during early mouse tongue development. Gene Expr Patterns. 2016;20:81-7 pubmed publisher
    ..Fgf13, Fgf15, Fgf16 and Fgf18 could all be detected with various intensities in the mesenchyme, whereas Fgf1 and Fgf2 were expressed in both the epithelium and the mesenchyme...
  49. Fei Y, Xiao L, Hurley M. Fibroblast growth factor 2 positively regulates expression of activating transcription factor 4 in osteoblasts. Biochem Biophys Res Commun. 2010;391:335-9 pubmed publisher
    Our previous studies showed that basic fibroblast growth factor 2 (FGF2) null mice display markedly reduced bone mass and bone formation. However, the mechanism by which FGF2 regulates bone mass or bone formation is not fully defined...
  50. Krejci P, Prochazkova J, Bryja V, Jelinkova P, Pejchalova K, Kozubik A, et al. Fibroblast growth factor inhibits interferon gamma-STAT1 and interleukin 6-STAT3 signaling in chondrocytes. Cell Signal. 2009;21:151-60 pubmed publisher
    ..Since cytokine-gp130 signaling represents an important positive regulator of cartilage, its inhibition may contribute to the growth-inhibitory effect of FGFR3 in cartilage. ..
  51. Haddad R, Morrow A, Plass C, Held W. Restriction landmark genomic scanning of mouse liver tumors for gene amplification: overexpression of cyclin A2. Biochem Biophys Res Commun. 2000;274:188-96 pubmed
    ..RLGS analysis revealed one tumor-specific amplification mapping close to CcnA2 (cyclin A2) and Fgf2 (fibroblast growth factor 2)...
  52. Guan X, Nie L, He T, Yang K, Xiao T, Wang S, et al. Klotho suppresses renal tubulo-interstitial fibrosis by controlling basic fibroblast growth factor-2 signalling. J Pathol. 2014;234:560-72 pubmed publisher
    Increased basic fibroblast growth factor-2 (FGF2) and reduced Klotho have both been reported to be closely associated with renal fibrosis. However, the relationship between Klotho and FGF2 remains unclear...
  53. Aigner A, Ray P, Czubayko F, Wellstein A. Immunolocalization of an FGF-binding protein reveals a widespread expression pattern during different stages of mouse embryo development. Histochem Cell Biol. 2002;117:1-11 pubmed
    Fibroblast growth factors (FGFs) play important roles during fetal and embryonic development. FGF-2 (basic FGF, bFGF) is widely expressed in the embryo and has been linked to tissue growth and remodeling...
  54. Gotoh N. Control of stemness by fibroblast growth factor signaling in stem cells and cancer stem cells. Curr Stem Cell Res Ther. 2009;4:9-15 pubmed
    ..Recent emerging evidence suggests that the FGF-ERK axis controls stemness via multiple modes of action. I would like to summarize current understanding of this subject from recent discoveries in this field. ..
  55. Sirko S, von Holst A, Weber A, Wizenmann A, Theocharidis U, Gotz M, et al. Chondroitin sulfates are required for fibroblast growth factor-2-dependent proliferation and maintenance in neural stem cells and for epidermal growth factor-dependent migration of their progeny. Stem Cells. 2010;28:775-87 pubmed publisher
    ..We conclude that neural stem/progenitor cell subpopulations reside in neurospheres that are distinguishable by their responsiveness to FGF-2 and EGF which is differentially regulated by CS-carbohydrate structures. ..
  56. Hajihosseini M, Heath J. Expression patterns of fibroblast growth factors-18 and -20 in mouse embryos is suggestive of novel roles in calvarial and limb development. Mech Dev. 2002;113:79-83 pubmed
  57. Yang J, Boerm M, McCarty M, Bucana C, Fidler I, Zhuang Y, et al. Mekk3 is essential for early embryonic cardiovascular development. Nat Genet. 2000;24:309-13 pubmed
    ..We conclude that Mekk3 is necessary for blood vessel development and may be a possible target for drugs that control angiogenesis. ..
  58. Kang H, Kim J, Kwon H, Nam K, Youn H, Sok D, et al. Basic fibroblast growth factor activates ERK and induces c-fos in human embryonic stem cell line MizhES1. Stem Cells Dev. 2005;14:395-401 pubmed
    ..state in vitro by growing them on feeder layers of mouse embryonic fibroblast (MEF) cells along with basic fibroblast growth factor (bFGF/FGF-2)...
  59. Ghadiali R, Guimond S, Turnbull J, Pisconti A. Dynamic changes in heparan sulfate during muscle differentiation and ageing regulate myoblast cell fate and FGF2 signalling. Matrix Biol. 2017;59:54-68 pubmed publisher
    ..increase in 6-O sulfation is also observed in the heparanome of ageing muscle, which we show leads to promotion of FGF2 signalling and satellite cell proliferation, suggesting a role for the heparanome dynamics in age-associated loss ..
  60. Lukaszewicz A, Savatier P, Cortay V, Kennedy H, Dehay C. Contrasting effects of basic fibroblast growth factor and neurotrophin 3 on cell cycle kinetics of mouse cortical stem cells. J Neurosci. 2002;22:6610-22 pubmed
    b>Basic fibroblast growth factor (bFGF) exerts a mitogenic effect on cortical neuroblasts, whereas neurotrophin 3 (NT3) promotes differentiation in these cells...
  61. Kiyota T, Ingraham K, Jacobsen M, Xiong H, Ikezu T. FGF2 gene transfer restores hippocampal functions in mouse models of Alzheimer's disease and has therapeutic implications for neurocognitive disorders. Proc Natl Acad Sci U S A. 2011;108:E1339-48 pubmed publisher
    ..To investigate the effect of neurogenesis on cognitive function in a relevant disease model, FGF2 gene is delivered bilaterally to the hippocampi of APP+presenilin-1 bigenic mice via an adenoassociated virus ..
  62. Munchhof A, Li F, White H, Mead L, Krier T, Fenoglio A, et al. Neurofibroma-associated growth factors activate a distinct signaling network to alter the function of neurofibromin-deficient endothelial cells. Hum Mol Genet. 2006;15:1858-69 pubmed
    ..Thus, these studies identify a unique biochemical pathway in Nf1+/- ECs as a potential therapeutic target in the neurofibroma microenvironment...
  63. Werner S, Breeden M, Hübner G, Greenhalgh D, Longaker M. Induction of keratinocyte growth factor expression is reduced and delayed during wound healing in the genetically diabetic mouse. J Invest Dermatol. 1994;103:469-73 pubmed
  64. Viereck J, Bang C, Foinquinos A, Thum T. Regulatory RNAs and paracrine networks in the heart. Cardiovasc Res. 2014;102:290-301 pubmed publisher
    ..It also highlights therapeutic strategies targeting factors of pathological communication for the treatment of HF. ..
  65. Serls A, Doherty S, Parvatiyar P, Wells J, Deutsch G. Different thresholds of fibroblast growth factors pattern the ventral foregut into liver and lung. Development. 2005;132:35-47 pubmed
    ..of cardiac mesoderm, ventral foregut endoderm explants respond to exogenous fibroblast growth factor (FGF) 1 and FGF2 in a dose-dependent manner, with lower concentrations activating liver specific genes and higher concentrations ..
  66. Salmaso N, Stevens H, McNeill J, Elsayed M, Ren Q, Maragnoli M, et al. Fibroblast Growth Factor 2 Modulates Hypothalamic Pituitary Axis Activity and Anxiety Behavior Through Glucocorticoid Receptors. Biol Psychiatry. 2016;80:479-489 pubmed publisher
    Despite strong evidence linking fibroblast growth factor 2 (FGF2) with anxiety and depression in both rodents and humans, the molecular mechanisms linking FGF2 with anxiety are not understood...
  67. Richardson G, Bazzi H, Fantauzzo K, Waters J, Crawford H, Hynd P, et al. KGF and EGF signalling block hair follicle induction and promote interfollicular epidermal fate in developing mouse skin. Development. 2009;136:2153-64 pubmed publisher
    ..We have also uncovered a previously unrecognised role for KGF signalling in the formation of hair follicles in the mouse. ..
  68. Lee M, Park H, Park M, Lee S, Kim S, Choi J, et al. Erk pathway and activator protein 1 play crucial roles in FGF2-stimulated premature cranial suture closure. Dev Dyn. 2003;227:335-46 pubmed
    ..We observed that placing FGF2-soaked bead on the osteogenic fronts of cultured mouse calvaria accelerates cranial suture closure and strongly ..
  69. Zhang X, Mernaugh G, Yang D, Gewin L, Srichai M, Harris R, et al. beta1 integrin is necessary for ureteric bud branching morphogenesis and maintenance of collecting duct structural integrity. Development. 2009;136:3357-66 pubmed publisher
    ..Thus beta1 integrins can regulate organ branching morphogenesis during development by mediating growth-factor-dependent signaling in addition to their well-defined role as adhesion receptors. ..
  70. Kato M, Ishii K, Iwamoto Y, Sasaki T, Kanda H, Yamada Y, et al. Activation of FGF2-FGFR signaling in the castrated mouse prostate stimulates the proliferation of basal epithelial cells. Biol Reprod. 2013;89:81 pubmed publisher
    ..After castration, mRNA expression levels of specific growth factors, such as Fgf2, Fgf7, Hgf, Tgfa, and Tgfb, were relatively abundant in whole mouse DLPs...
  71. Armstrong R, Le T, Frost E, Borke R, Vana A. Absence of fibroblast growth factor 2 promotes oligodendroglial repopulation of demyelinated white matter. J Neurosci. 2002;22:8574-85 pubmed
    This study takes advantage of fibroblast growth factor 2 (FGF2) knock-out mice to determine the contribution of FGF2 to the regeneration of oligodendrocytes in the adult CNS...
  72. Giese N, Gazzinelli R, Actor J, Morawetz R, Sarzotti M, Morse H. Retrovirus-elicited interleukin-12 and tumour necrosis factor-alpha as inducers of interferon-gamma-mediated pathology in mouse AIDS. Immunology. 1996;87:467-74 pubmed
    ..These studies suggest that continuing low-level expression of IFN-gamma, stimulated by IL-12 and TNF-alpha, contributes to the susceptibility of B6 mice to MAIDS but is not required for the resistance of BALB/c mice to disease. ..
  73. Kudla A, John M, Bowen Pope D, Rainish B, Olwin B. A requirement for fibroblast growth factor in regulation of skeletal muscle growth and differentiation cannot be replaced by activation of platelet-derived growth factor signaling pathways. Mol Cell Biol. 1995;15:3238-46 pubmed
    ..Activation of PDGF beta receptor tyrosine kinase activity, stimulation of MAP kinase, and upregulation of immediate-early gene expression are not sufficient to repress skeletal muscle differentiation. ..
  74. Hebert J, Basilico C, Goldfarb M, Haub O, Martin G. Isolation of cDNAs encoding four mouse FGF family members and characterization of their expression patterns during embryogenesis. Dev Biol. 1990;138:454-63 pubmed
    ..b>Fgfb expression showed the greatest tissue-specific variability in abundance, with the highest levels detected in the ..
  75. Murdoch B, Roskams A. Fibroblast growth factor signaling regulates neurogenesis at multiple stages in the embryonic olfactory epithelium. Stem Cells Dev. 2013;22:525-37 pubmed publisher
    ..Neurogenic drive at each stage is governed largely by exogenous factors. Fibroblast growth factor 2 (FGF2) is believed to increase cell proliferation in both presumptive OE stem cells and immediate ..
  76. Ishii K, Kanatsu Shinohara M, Toyokuni S, Shinohara T. FGF2 mediates mouse spermatogonial stem cell self-renewal via upregulation of Etv5 and Bcl6b through MAP2K1 activation. Development. 2012;139:1734-43 pubmed publisher
    b>Fibroblast growth factor 2 (FGF2) and glial cell line-derived neurotrophic factor (GDNF) are required to recapitulate spermatogonial stem cell (SSC) self-renewal in vitro...
  77. Markowska A, Liu F, Panjwani N. Galectin-3 is an important mediator of VEGF- and bFGF-mediated angiogenic response. J Exp Med. 2010;207:1981-93 pubmed publisher
    ..We demonstrate here that galectin-3 is a mediator of vascular endothelial growth factor (VEGF)- and basic fibroblast growth factor (bFGF)-mediated angiogenic response...
  78. Ogawa T, Shimokawa H, Fukada K, Suzuki S, Shibata S, Ohya K, et al. Localization and inhibitory effect of basic fibroblast growth factor on chondrogenesis in cultured mouse mandibular condyle. J Bone Miner Metab. 2003;21:145-53 pubmed
    ..To elucidate the mechanism of chondrogenesis at the condylar cartilage, we analyzed the effects of basic fibroblast growth factor (bFGF) on the growth and development of mouse mandibular condyle using serum-free organ culture and on ..
  79. Rabaneda L, Carrasco M, Lopez Toledano M, Murillo Carretero M, Ruiz F, Estrada C, et al. Homocysteine inhibits proliferation of neuronal precursors in the mouse adult brain by impairing the basic fibroblast growth factor signaling cascade and reducing extracellular regulated kinase 1/2-dependent cyclin E expression. FASEB J. 2008;22:3823-35 pubmed publisher
    ..We show that Hcy exerts an antiproliferative effect on basic fibroblast growth factor (bFGF) -stimulated NPCs isolated from the postnatal subventricular zone (SVZ), accompanied by ..
  80. Naruse M, Shibasaki K, Ishizaki Y. FGF-2 signal promotes proliferation of cerebellar progenitor cells and their oligodendrocytic differentiation at early postnatal stage. Biochem Biophys Res Commun. 2015;463:1091-6 pubmed publisher
    ..These results suggest that CD44-positive cells might be a source of cerebellar oligodendrocytes and that FGF-2 plays important roles in their development at an early postnatal stage. ..
  81. Guo Z, Yao G, Fu L, Fu Z, Hou B. Effect of recombinant human endostatin on the expression of c-Myc and bFGF in mouse gastric cancer cells. Genet Mol Res. 2015;14:5258-65 pubmed publisher
    ..The expression of c-Myc and basic fibroblast growth factor (bFGF) was determined by reverse transcription-polymerase chain reaction, Western blotting, and immu-..
  82. Hu Y, Zhang J, Li S, Wang C, Chu L, Zhang Z, et al. The transcription activity of heat shock factor 4b is regulated by FGF2. Int J Biochem Cell Biol. 2013;45:317-25 pubmed publisher
    ..Here we present that Hsf4b transcription activity is regulated by FGF2 a key growth factor that is involved in regulating lens development at multiple stages...
  83. Shimoaka T, Ogasawara T, Yonamine A, Chikazu D, Kawano H, Nakamura K, et al. Regulation of osteoblast, chondrocyte, and osteoclast functions by fibroblast growth factor (FGF)-18 in comparison with FGF-2 and FGF-10. J Biol Chem. 2002;277:7493-500 pubmed
    ..All these effects of FGF-18 bore a close resemblance to those of FGF-2, whereas FGF-10 affects none of these cells. FGF-18 may therefore compensate for the action of FGF-2 on bone and cartilage. ..