Gene Symbol: Fgf17
Description: fibroblast growth factor 17
Alias: fibroblast growth factor 17, FGF-17
Species: mouse
Products:     Fgf17

Top Publications

  1. Chi C, Martinez S, Wurst W, Martin G. The isthmic organizer signal FGF8 is required for cell survival in the prospective midbrain and cerebellum. Development. 2003;130:2633-44 pubmed
    ..75). This resulted in a failure to maintain expression of Wnt1 as well as Fgf17, Fgf18, and Gbx2 in the mes/met at early somite stages, and in the absence of the midbrain and cerebellum at E17.5...
  2. Hoshikawa M, Ohbayashi N, Yonamine A, Konishi M, Ozaki K, Fukui S, et al. Structure and expression of a novel fibroblast growth factor, FGF-17, preferentially expressed in the embryonic brain. Biochem Biophys Res Commun. 1998;244:187-91 pubmed
    ..5 by in situ hybridization. The present results indicate that FGF-17 might be a novel secreted signaling molecule in the induction and patterning of the embryonic brain. ..
  3. Basson M, Echevarria D, Ahn C, Sudarov A, Joyner A, Mason I, et al. Specific regions within the embryonic midbrain and cerebellum require different levels of FGF signaling during development. Development. 2008;135:889-98 pubmed publisher
    ..We suggest a molecular explanation for this phenomenon by providing evidence that FGF signaling functions to inhibit the BMP signaling that promotes roof plate development. ..
  4. Bachler M, Neubüser A. Expression of members of the Fgf family and their receptors during midfacial development. Mech Dev. 2001;100:313-6 pubmed
    ..Expression of Fgf8, Fgf9, Fgf10 and Fgf17 was still observed in these domains at E11.5...
  5. Cholfin J, Rubenstein J. Frontal cortex subdivision patterning is coordinately regulated by Fgf8, Fgf17, and Emx2. J Comp Neurol. 2008;509:144-55 pubmed publisher
    ..of gene expression markers that delineate neonatal FC subdivisions and identified FC regionalization defects in Fgf17-/- mutant mice (Cholfin and Rubenstein [2007] Proc. Natl. Acad. Sci. U. S. A. [in press])...
  6. Sun X, Mariani F, Martin G. Functions of FGF signalling from the apical ectodermal ridge in limb development. Nature. 2002;418:501-8 pubmed
    ..In the complete absence of both FGF4 and FGF8 activities, limb development fails. We present a model to explain how the mutant phenotypes arise from FGF-mediated effects on limb bud size and cell survival. ..
  7. Mariani F, Ahn C, Martin G. Genetic evidence that FGFs have an instructive role in limb proximal-distal patterning. Nature. 2008;453:401-5 pubmed publisher
    ..Fibroblast growth factor (FGF) gene family members are key AER-derived signals, with Fgf4, Fgf8, Fgf9 and Fgf17 expressed specifically in the mouse AER...
  8. Xu J, Lawshe A, MacArthur C, Ornitz D. Genomic structure, mapping, activity and expression of fibroblast growth factor 17. Mech Dev. 1999;83:165-78 pubmed
    ..It exhibits 60% amino acid identity with Fgf8 and 50% identity with Fgf8. Both Fgf8 and Fgf17 have a similar structure and a similar pattern of alternative splicing in the 5' coding region...
  9. Wang Y, Song L, Zhou C. The canonical Wnt/?-catenin signaling pathway regulates Fgf signaling for early facial development. Dev Biol. 2011;349:250-60 pubmed publisher
    ..Gene expression of several cell-survival and patterning factors, including Fgf8, Fgf3, and Fgf17, is dramatically diminished in the anterior neural ridge (ANR, a rostral signaling center) and/or the adjacent ..

More Information


  1. Michos O, Panman L, Vintersten K, Beier K, Zeller R, Zuniga A. Gremlin-mediated BMP antagonism induces the epithelial-mesenchymal feedback signaling controlling metanephric kidney and limb organogenesis. Development. 2004;131:3401-10 pubmed
    ..As a consequence, the metanephric mesenchyme is eliminated by apoptosis, in the same way as the core mesenchymal cells of the limb bud. ..
  2. Liu A, Li J, Bromleigh C, Lao Z, Niswander L, Joyner A. FGF17b and FGF18 have different midbrain regulatory properties from FGF8b or activated FGF receptors. Development. 2003;130:6175-85 pubmed
    ..and cerebellum is regulated by a mid/hindbrain organizer that produces three fibroblast growth factors (FGF8, FGF17 and FGF18)...
  3. Xu J, Liu Z, Ornitz D. Temporal and spatial gradients of Fgf8 and Fgf17 regulate proliferation and differentiation of midline cerebellar structures. Development. 2000;127:1833-43 pubmed
    ..Fgf8 is thought to mediate this organizer function. In addition to Fgf8, Fgf17 and Fgf18 are also expressed in the MHB junction. Fgf17 is expressed later and broader than either Fgf8 or Fgf18...
  4. Fukuchi Shimogori T, Grove E. Emx2 patterns the neocortex by regulating FGF positional signaling. Nat Neurosci. 2003;6:825-31 pubmed
    ..These findings begin to clarify the signaling network that patterns the neocortical area map. ..
  5. Liu Y, Liu C, Yamada Y, Fan C. Growth arrest specific gene 1 acts as a region-specific mediator of the Fgf10/Fgf8 regulatory loop in the limb. Development. 2002;129:5289-300 pubmed
    ..Our data provide evidence that Gas1 acts to maintain high levels of FGF10 at the tip mesenchyme and support the proposal that Fgf10 expression in this region is crucial for maintaining Fgf8 expression in the AER. ..
  6. Scearce Levie K, Roberson E, Gerstein H, Cholfin J, Mandiyan V, Shah N, et al. Abnormal social behaviors in mice lacking Fgf17. Genes Brain Behav. 2008;7:344-54 pubmed
    ..b>Fibroblast growth factor 17 (Fgf17) has been shown to contribute to regionalization of the rodent frontal cortex...
  7. Kawase E, Hashimoto K, Pedersen R. Autocrine and paracrine mechanisms regulating primordial germ cell proliferation. Mol Reprod Dev. 2004;68:5-16 pubmed
    ..We account for these findings in a model involving regulation of PGC proliferation, in which SCF modulates the response to FGFs. ..
  8. Lewandoski M, Sun X, Martin G. Fgf8 signalling from the AER is essential for normal limb development. Nat Genet. 2000;26:460-3 pubmed
    ..Of the four mouse Fgf genes (Fgf4 , Fgf8, Fgf9, Fgf17) known to display AER-specific expression domains within the limb bud (AER-Fgfs), only Fgf8 is expressed ..
  9. Eblaghie M, Song S, Kim J, Akita K, Tickle C, Jung H. Interactions between FGF and Wnt signals and Tbx3 gene expression in mammary gland initiation in mouse embryos. J Anat. 2004;205:1-13 pubmed
    ..we detected expression of Fgfr1b, Fgf8 and Fgf9 in both surface ectoderm and mammary bud epithelium, and Fgf4 and Fgf17 in mammary bud epithelium...
  10. Hasegawa H, Ashigaki S, Takamatsu M, Suzuki Migishima R, Ohbayashi N, Itoh N, et al. Laminar patterning in the developing neocortex by temporally coordinated fibroblast growth factor signaling. J Neurosci. 2004;24:8711-9 pubmed
  11. Jin Y, Han X, Taketo M, Yoon J. Wnt9b-dependent FGF signaling is crucial for outgrowth of the nasal and maxillary processes during upper jaw and lip development. Development. 2012;139:1821-30 pubmed publisher
    ..Our study has identified a previously unknown regulatory link between WNT9B and FGF signaling during lip and upper jaw development...
  12. Sgaier S, Lao Z, Villanueva M, Berenshteyn F, Stephen D, Turnbull R, et al. Genetic subdivision of the tectum and cerebellum into functionally related regions based on differential sensitivity to engrailed proteins. Development. 2007;134:2325-35 pubmed
    ..Our study suggests that an ;engrailed code' is integral to partitioning the tectum and cerebellum into functional domains. ..
  13. Godbole G, Roy A, Shetty A, Tole S. Novel functions of LHX2 and PAX6 in the developing telencephalon revealed upon combined loss of both genes. Neural Dev. 2017;12:19 pubmed publisher
  14. Jen Y, Musacchio M, Lander A. Glypican-1 controls brain size through regulation of fibroblast growth factor signaling in early neurogenesis. Neural Dev. 2009;4:33 pubmed publisher
    ..Through the analysis of compound mutants, we provide strong evidence that Fgf17 is the FGF family member through which Gpc1 controls brain size...
  15. Reid B, Yang H, Melvin V, Taketo M, Williams T. Ectodermal Wnt/?-catenin signaling shapes the mouse face. Dev Biol. 2011;349:261-9 pubmed publisher
  16. Waters S, Lewandoski M. A threshold requirement for Gbx2 levels in hindbrain development. Development. 2006;133:1991-2000 pubmed
    ..Hence, instead of expressing r1 markers, this region displays robust expression of Fgf8 and Fgf17, as well as the downstream FGF targets Spry1 and Spry4...
  17. Sun X, Lewandoski M, Meyers E, Liu Y, Maxson R, Martin G. Conditional inactivation of Fgf4 reveals complexity of signalling during limb bud development. Nat Genet. 2000;25:83-6 pubmed
    ..We also found that maintenance of Fgf9 and Fgf17 expression is dependent on Shh, whereas Fgf8 expression is not...
  18. Wright T, Hatch E, Karabagli H, Karabagli P, Schoenwolf G, Mansour S. Expression of mouse fibroblast growth factor and fibroblast growth factor receptor genes during early inner ear development. Dev Dyn. 2003;228:267-72 pubmed
    ..Fgf16 was expressed in the posterior otic cup and vesicle, suggesting roles in otic cell fate decisions and/or axis formation. ..
  19. Hajihosseini M, Heath J. Expression patterns of fibroblast growth factors-18 and -20 in mouse embryos is suggestive of novel roles in calvarial and limb development. Mech Dev. 2002;113:79-83 pubmed
  20. Hasenpusch Theil K, Watson J, Theil T. Direct Interactions Between Gli3, Wnt8b, and Fgfs Underlie Patterning of the Dorsal Telencephalon. Cereb Cortex. 2017;27:1137-1148 pubmed publisher
    ..is required for Wnt8b enhancer activity in the cortical hem, whereas Wnt/β-catenin signaling represses Fgf17 forebrain enhancer activity. In contrast, Fgf and Wnt/β-catenin signaling cooperate to regulate Gli3 expression...
  21. Lancioni A, Pizzo M, Fontanella B, Ferrentino R, Napolitano L, De Leonibus E, et al. Lack of Mid1, the mouse ortholog of the Opitz syndrome gene, causes abnormal development of the anterior cerebellar vermis. J Neurosci. 2010;30:2880-7 pubmed publisher
    ..of the midbrain/cerebellum boundary, and the downregulation of a key player in the development of this region, Fgf17. Thus, lack of Mid1 causes a misspecification of the midbrain/cerebellar boundary that results in an abnormal ..
  22. Sato T, Joyner A. The duration of Fgf8 isthmic organizer expression is key to patterning different tectal-isthmo-cerebellum structures. Development. 2009;136:3617-26 pubmed publisher
    ..We suggest that the remaining Fgf8 and Fgf17 signaling in our temporal Fgf8 conditional mutants is sufficient to ensure survival of most midbrain/hindbrain ..
  23. Hoch R, Clarke J, Rubenstein J. Fgf signaling controls the telencephalic distribution of Fgf-expressing progenitors generated in the rostral patterning center. Neural Dev. 2015;10:8 pubmed publisher
    ..Fgf expression patterns suggest that they mark functionally distinct RPC subdomains. We generated Fgf8(CreER) and Fgf17(CreER) mice and used them to analyze the lineages of Fgf8- versus Fgf17-expressing RPC cells...
  24. Farin H, Lüdtke T, Schmidt M, Placzko S, Schuster Gossler K, Petry M, et al. Tbx2 terminates shh/fgf signaling in the developing mouse limb bud by direct repression of gremlin1. PLoS Genet. 2013;9:e1003467 pubmed publisher
    ..We propose that proliferative expansion of Tbx2-expressing cells mediates self-termination of limb bud outgrowth due to their refractoriness to Grem1 induction. ..
  25. Takase H, Itoh T, Ino S, Wang T, Koji T, Akira S, et al. FGF7 is a functional niche signal required for stimulation of adult liver progenitor cells that support liver regeneration. Genes Dev. 2013;27:169-81 pubmed publisher
    ..These findings provide new insights into the cellular and molecular basis for LPC regulation and identify FGF7 as a potential therapeutic target for liver diseases. ..
  26. Goldman D, Martin G, Tam P. Fate and function of the ventral ectodermal ridge during mouse tail development. Development. 2000;127:2113-23 pubmed
    ..In situ hybridization analysis showed that the genes encoding the signaling molecules FGF17 and BMP2 are specifically expressed in the VER...
  27. Asada M, Shinomiya M, Suzuki M, Honda E, Sugimoto R, Ikekita M, et al. Glycosaminoglycan affinity of the complete fibroblast growth factor family. Biochim Biophys Acta. 2009;1790:40-8 pubmed publisher
    ..This is noteworthy, as the differential interactions of these growth factors with GAGs may be key determinants of their specific biological activities. ..
  28. Hirata H, Tomita K, Bessho Y, Kageyama R. Hes1 and Hes3 regulate maintenance of the isthmic organizer and development of the mid/hindbrain. EMBO J. 2001;20:4454-66 pubmed
    ..These results indicate that Hes1 and Hes3 prevent premature differentiation and maintain the organizer activity of the isthmic cells, thereby regulating the development of the midbrain and anterior hindbrain. ..
  29. Dixit R, Wilkinson G, Cancino G, Shaker T, Adnani L, Li S, et al. Neurog1 and Neurog2 control two waves of neuronal differentiation in the piriform cortex. J Neurosci. 2014;34:539-53 pubmed publisher
    ..Neurog1 and Neurog2 thus have unique and redundant functions in the piriform cortex, controlling the timing of differentiation of early-born CR/lot cells and specifying the identities of later-born layer II/III neurons. ..
  30. Cholfin J, Rubenstein J. Patterning of frontal cortex subdivisions by Fgf17. Proc Natl Acad Sci U S A. 2007;104:7652-7 pubmed
    ..Using a set of gene expression markers that distinguish subdivisions of the newborn mouse FC, we show that loss of Fgf17 selectively reduces the size of the dorsal FC whereas ventral/orbital FC appears normal...
  31. Zhao X, Duester G. Effect of retinoic acid signaling on Wnt/beta-catenin and FGF signaling during body axis extension. Gene Expr Patterns. 2009;9:430-5 pubmed publisher
    ..Fgf8, Wnt8a, and Wnt3a expand anteriorly into the trunk, but no change is observed in caudal expression of Fgf4 or Fgf17 plus caudal expression of Fgf18 and Cdx1 is reduced...
  32. Ross A, Mansilla M, Choe Y, Helminski S, Sturm R, Maute R, et al. A mutation in mouse Pak1ip1 causes orofacial clefting while human PAK1IP1 maps to 6p24 translocation breaking points associated with orofacial clefting. PLoS ONE. 2013;8:e69333 pubmed publisher
    ..No deleterious variants in the PAK1IP1 gene coding region were recognized, however, we identified a borderline association effect for SNP rs494723 suggesting a possible role for the PAK1IP1 gene in human orofacial clefting. ..
  33. Barber M, Arai Y, Morishita Y, Vigier L, Causeret F, Borello U, et al. Migration Speed of Cajal-Retzius Cells Modulated by Vesicular Trafficking Controls the Size of Higher-Order Cortical Areas. Curr Biol. 2015;25:2466-78 pubmed publisher
    ..Our findings thus identify novel roles for neuronal migration and VAMP3-dependent vesicular trafficking in cortical wiring. ..
  34. Satoh W, Gotoh T, Tsunematsu Y, Aizawa S, Shimono A. Sfrp1 and Sfrp2 regulate anteroposterior axis elongation and somite segmentation during mouse embryogenesis. Development. 2006;133:989-99 pubmed
    ..This study suggests that Wnt regulation by Sfrp1 and Sfrp2 is required for embryonic patterning. ..
  35. Zhong W, Wang Q, Sun T, Wang F, Liu J, Leach R, et al. FGF ligand family mRNA expression profile for mouse preimplantation embryos, early gestation human placenta, and mouse trophoblast stem cells. Mol Reprod Dev. 2006;73:540-50 pubmed
    ..RT-PCR was done for developmentally important FGF subfamilies, FGF10/FGF22 and FGF8/FGF17/FGF18 as well as FGF11. FGF4 and FGF18 are detected at highest levels by RT-PCR and microarrays...
  36. Guo Q, Li K, Sunmonu N, Li J. Fgf8b-containing spliceforms, but not Fgf8a, are essential for Fgf8 function during development of the midbrain and cerebellum. Dev Biol. 2010;338:183-92 pubmed publisher
    ..To determine if Fgf17, which is expressed in the MHB region and possesses similar activities to Fgf8a based on gain-of-function studies, ..
  37. Miraoui H, Dwyer A, Sykiotis G, Plummer L, CHUNG W, Feng B, et al. Mutations in FGF17, IL17RD, DUSP6, SPRY4, and FLRT3 are identified in individuals with congenital hypogonadotropic hypogonadism. Am J Hum Genet. 2013;92:725-43 pubmed publisher
    ..Except for FGF18 and SPRY2, all other genes were found to be mutated in CHH individuals: FGF17 (n = 3 individuals), IL17RD (n = 8), DUSP6 (n = 5), SPRY4 (n = 14), and FLRT3 (n = 3)...
  38. Wahl M, Deng C, Lewandoski M, Pourquie O. FGF signaling acts upstream of the NOTCH and WNT signaling pathways to control segmentation clock oscillations in mouse somitogenesis. Development. 2007;134:4033-41 pubmed
    ..Together, these experiments provide genetic evidence for the role of FGF signaling in segmentation, and identify a signaling hierarchy controlling clock oscillations downstream of FGF signaling in the mouse. ..
  39. Du W, Prochazka J, Prochazkova M, Klein O. Expression of FGFs during early mouse tongue development. Gene Expr Patterns. 2016;20:81-7 pubmed publisher
    ..Our results indicate that FGF signaling regulates tongue development at multiple stages. ..
  40. Sahara S, O Leary D. Fgf10 regulates transition period of cortical stem cell differentiation to radial glia controlling generation of neurons and basal progenitors. Neuron. 2009;63:48-62 pubmed publisher
  41. Roy A, Gonzalez Gomez M, Pierani A, Meyer G, Tole S. Lhx2 regulates the development of the forebrain hem system. Cereb Cortex. 2014;24:1361-72 pubmed publisher
    ..Since all components of the forebrain hem system have been identified across several vertebrate species, the mechanisms that regulate them may have played a fundamental role in driving key aspects of forebrain evolution. ..
  42. Toyoda R, Assimacopoulos S, Wilcoxon J, Taylor A, Feldman P, Suzuki Hirano A, et al. FGF8 acts as a classic diffusible morphogen to pattern the neocortex. Development. 2010;137:3439-48 pubmed publisher
    ..These observations support FGF8 as a classic diffusible morphogen in neocortex, thereby guiding future studies of neocortical pattern formation. ..
  43. Zhang Y, Li S, Yuan L, Tian Y, Weidenfeld J, Yang J, et al. Foxp1 coordinates cardiomyocyte proliferation through both cell-autonomous and nonautonomous mechanisms. Genes Dev. 2010;24:1746-57 pubmed publisher
    ..Endocardial loss of Foxp1 results in decreased Fgf3/Fgf16/Fgf17/Fgf20 expression in the heart, leading to reduced cardiomyocyte proliferation...
  44. Maruoka Y, Ohbayashi N, Hoshikawa M, Itoh N, Hogan B, Furuta Y. Comparison of the expression of three highly related genes, Fgf8, Fgf17 and Fgf18, in the mouse embryo. Mech Dev. 1998;74:175-7 pubmed
    ..Here, we report the expression from early streak stage to midgestation of two newly-identified murine genes, Fgf17 and Fgf18, that are most closely related to Fgf8 (63.7% and 56...
  45. Kasberg A, Brunskill E, Steven Potter S. SP8 regulates signaling centers during craniofacial development. Dev Biol. 2013;381:312-23 pubmed publisher
    ..The most dramatic differences included striking reductions in Fgf8 and Fgf17 expression in the ANR and OP signaling centers...
  46. Yu X, Nieman B, Sudarov A, Szulc K, Abdollahian D, Bhatia N, et al. Morphological and functional midbrain phenotypes in Fibroblast Growth Factor 17 mutant mice detected by Mn-enhanced MRI. Neuroimage. 2011;56:1251-8 pubmed publisher
    ..Previous studies have shown that the brains of Fibroblast Growth Factor 17 null mutants (Fgf17(-/-)) have anatomical abnormalities in the inferior colliculus (IC)-the auditory ..
  47. Zhong W, Jiang M, Schonemann M, Meneses J, Pedersen R, Jan L, et al. Mouse numb is an essential gene involved in cortical neurogenesis. Proc Natl Acad Sci U S A. 2000;97:6844-9 pubmed
    ..5 (E11. 5). These findings suggest that m-numb is an essential gene that plays a role in promoting progenitor cell fate during cortical neurogenesis. ..
  48. Paek H, Hwang J, Zukin R, Hebert J. ?-Catenin-dependent FGF signaling sustains cell survival in the anterior embryonic head by countering Smad4. Dev Cell. 2011;20:689-99 pubmed publisher
    ..Moreover, these antagonistic pathways converge on the transcriptional regulation of apoptosis, and genes such as Cdkn1a, suggesting a mechanism for how signaling centers in the embryonic head regulate cell survival...