Fgf15

Summary

Gene Symbol: Fgf15
Description: fibroblast growth factor 15
Alias: FGF19, fibroblast growth factor 15, FGF-15
Species: mouse
Products:     Fgf15

Top Publications

  1. Katoh M, Katoh M. Evolutionary conservation of CCND1-ORAOV1-FGF19-FGF4 locus from zebrafish to human. Int J Mol Med. 2003;12:45-50 pubmed
    The CCND1-ORAOV1-FGF19-FGF4-FGF3-FLJ10261-FADD-PPFIA1-EMS1 locus on human chromosome 11q13 is frequently amplified in esophageal cancer, breast cancer, and bladder tumors...
  2. Inagaki T, Choi M, Moschetta A, Peng L, Cummins C, McDonald J, et al. Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis. Cell Metab. 2005;2:217-25 pubmed
    ..Here, we demonstrate that fibroblast growth factor 15 (FGF15) signals from intestine to liver to repress the gene encoding cholesterol 7alpha-hydroxylase (..
  3. Kurosu H, Choi M, Ogawa Y, Dickson A, Goetz R, Eliseenkova A, et al. Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21. J Biol Chem. 2007;282:26687-95 pubmed
    The fibroblast growth factor (FGF) 19 subfamily of ligands, FGF19, FGF21, and FGF23, function as hormones that regulate bile acid, fatty acid, glucose, and phosphate metabolism in target organs through activating FGF receptors (FGFR1-4)...
  4. Kurosu H, Kuro O M. The Klotho gene family as a regulator of endocrine fibroblast growth factors. Mol Cell Endocrinol. 2009;299:72-8 pubmed publisher
    ..axis, recent studies has shown that betaKlotho, a Klotho family protein, also functions as a cofactor required for FGF19 and FGF21 signaling and determines the tissue-specific metabolic activities of FGF19 and FGF21...
  5. Wu X, Ge H, Lemon B, Vonderfecht S, Weiszmann J, Hecht R, et al. FGF19-induced hepatocyte proliferation is mediated through FGFR4 activation. J Biol Chem. 2010;285:5165-70 pubmed publisher
    b>FGF19 and FGF21, unique members of the fibroblast growth factor (FGF) family, are hormones that regulate glucose, lipid, and energy homeostasis...
  6. Wu X, Ge H, Lemon B, Vonderfecht S, Baribault H, Weiszmann J, et al. Separating mitogenic and metabolic activities of fibroblast growth factor 19 (FGF19). Proc Natl Acad Sci U S A. 2010;107:14158-63 pubmed publisher
    b>FGF19 and FGF21 are distinctive members of the FGF family that function as endocrine hormones...
  7. Itoh N, Ornitz D. Functional evolutionary history of the mouse Fgf gene family. Dev Dyn. 2008;237:18-27 pubmed
    ..The mammalian Fgf family can be divided into the intracellular Fgf11/12/13/14 subfamily (iFGFs), the hormone-like Fgf15/21/23 subfamily (hFGFs), and the canonical Fgf subfamilies, including Fgf1/2/5, Fgf3/4/6, Fgf7/10/22, Fgf8/17/18, ..
  8. Asada M, Shinomiya M, Suzuki M, Honda E, Sugimoto R, Ikekita M, et al. Glycosaminoglycan affinity of the complete fibroblast growth factor family. Biochim Biophys Acta. 2009;1790:40-8 pubmed publisher
    ..We found that members of the FGF19 subfamily (i.e...
  9. Wu X, Ge H, Lemon B, Weiszmann J, Gupte J, Hawkins N, et al. Selective activation of FGFR4 by an FGF19 variant does not improve glucose metabolism in ob/ob mice. Proc Natl Acad Sci U S A. 2009;106:14379-84 pubmed publisher
    b>FGF19 is a hormone that regulates bile acid and glucose homeostasis. Progress has been made in identifying cofactors for receptor activation...

More Information

Publications82

  1. Potthoff M, Bonéy Montoya J, Choi M, He T, Sunny N, Satapati S, et al. FGF15/19 regulates hepatic glucose metabolism by inhibiting the CREB-PGC-1? pathway. Cell Metab. 2011;13:729-38 pubmed publisher
    ..Here, we show that the hormone fibroblast growth factor 15/19 (FGF15/19), which is released postprandially from the small intestine, inhibits hepatic ..
  2. Hasenpusch Theil K, Watson J, Theil T. Direct Interactions Between Gli3, Wnt8b, and Fgfs Underlie Patterning of the Dorsal Telencephalon. Cereb Cortex. 2017;27:1137-1148 pubmed publisher
    ..Hence, our study provides a framework for understanding the genetic circuitry underlying telencephalic patterning and how defects in this process can affect the formation of cortical areas. ..
  3. Ishibashi M, McMahon A. A sonic hedgehog-dependent signaling relay regulates growth of diencephalic and mesencephalic primordia in the early mouse embryo. Development. 2002;129:4807-19 pubmed
    ..We present evidence that Fgf15 shows Shh-dependent expression in the diencephalon and may participate in this interaction, at least in part, by ..
  4. Ferrell J, Boehme S, Li F, Chiang J. Cholesterol 7?-hydroxylase-deficient mice are protected from high-fat/high-cholesterol diet-induced metabolic disorders. J Lipid Res. 2016;57:1144-54 pubmed publisher
  5. Choi M, Moschetta A, Bookout A, Peng L, Umetani M, Holmstrom S, et al. Identification of a hormonal basis for gallbladder filling. Nat Med. 2006;12:1253-5 pubmed
    ..These studies demonstrate that gallbladder filling is actively regulated by an endocrine pathway and suggest a postprandial timing mechanism that controls gallbladder motility. ..
  6. McWhirter J, Goulding M, Weiner J, Chun J, Murre C. A novel fibroblast growth factor gene expressed in the developing nervous system is a downstream target of the chimeric homeodomain oncoprotein E2A-Pbx1. Development. 1997;124:3221-32 pubmed
  7. Wang H, Venkatesh M, Li H, Goetz R, Mukherjee S, Biswas A, et al. Pregnane X receptor activation induces FGF19-dependent tumor aggressiveness in humans and mice. J Clin Invest. 2011;121:3220-32 pubmed publisher
    ..Furthermore, we were able to show that this PXR-mediated phenotype required FGF19 signaling...
  8. Kim Y, Byun S, Zhang Y, Seok S, Kemper B, Ma J, et al. Liver ChIP-seq analysis in FGF19-treated mice reveals SHP as a global transcriptional partner of SREBP-2. Genome Biol. 2015;16:268 pubmed publisher
    Fibroblast growth factor-19 (FGF19) is an intestinal hormone that mediates postprandial metabolic responses in the liver...
  9. Thein T, de Melo J, Zibetti C, Clark B, Juarez F, Blackshaw S. Control of lens development by Lhx2-regulated neuroretinal FGFs. Development. 2016;143:3994-4002 pubmed
    ..These data demonstrate that neuroretinal expression of Lhx2 and neuroretina-derived FGF factors are crucial for lens fiber development in vivo. ..
  10. Cai Z, Feng G, Zhang X. Temporal requirement of the protein tyrosine phosphatase Shp2 in establishing the neuronal fate in early retinal development. J Neurosci. 2010;30:4110-9 pubmed publisher
    ..Together, these results demonstrate that Shp2 mediates FGF-Ras signaling to control retinal progenitor cell fate. ..
  11. DeChiara T, Brosius J. Neural BC1 RNA: cDNA clones reveal nonrepetitive sequence content. Proc Natl Acad Sci U S A. 1987;84:2624-8 pubmed
    ..Moreover, the availability of a unique BC1 RNA sequence will facilitate studies on tissue- and stage-specific gene regulation and will help in clarifying the role of this small RNA in the brain. ..
  12. Katafuchi T, Esterházy D, Lemoff A, Ding X, Sondhi V, Kliewer S, et al. Detection of FGF15 in plasma by stable isotope standards and capture by anti-peptide antibodies and targeted mass spectrometry. Cell Metab. 2015;21:898-904 pubmed publisher
    b>Fibroblast growth factor 15 (FGF15) has been proposed as a postprandial hormone that signals from intestine to liver to regulate bile acid and carbohydrate homeostasis...
  13. Murali D, Kawaguchi Niida M, Deng C, Furuta Y. Smad4 is required predominantly in the developmental processes dependent on the BMP branch of the TGF-? signaling system in the embryonic mouse retina. Invest Ophthalmol Vis Sci. 2011;52:2930-7 pubmed publisher
    ..In addition, genetic requirements for Smad4 in the embryonic retina are evident predominantly in the developmental events regulated by the BMP branch of the TGF-? signaling pathway. ..
  14. Huang J, Liu Y, Oltean A, Beebe D. Bmp4 from the optic vesicle specifies murine retina formation. Dev Biol. 2015;402:119-26 pubmed publisher
    ..Differences in the signaling pathways required for specification of the retina and retinal pigmented epithelium in chicken and mouse embryos suggest major changes in signaling during the evolution of the vertebrate eye. ..
  15. Kir S, Beddow S, Samuel V, Miller P, Previs S, Suino Powell K, et al. FGF19 as a postprandial, insulin-independent activator of hepatic protein and glycogen synthesis. Science. 2011;331:1621-4 pubmed publisher
    ..Mice lacking FGF15 (the mouse FGF19 ortholog) fail to properly maintain blood concentrations of glucose and normal postprandial ..
  16. Zakin L, Reversade B, Virlon B, Rusniok C, Glaser P, Elalouf J, et al. Gene expression profiles in normal and Otx2-/- early gastrulating mouse embryos. Proc Natl Acad Sci U S A. 2000;97:14388-93 pubmed
    ..Among a broader list, the study of six genes found to be differentially expressed allows defining a role for Otx2 in the orchestration of cell movements leading to the adequate organization of the embryo before gastrulation. ..
  17. Xu X, Li C, Takahashi K, Slavkin H, Shum L, Deng C. Murine fibroblast growth factor receptor 1alpha isoforms mediate node regression and are essential for posterior mesoderm development. Dev Biol. 1999;208:293-306 pubmed
    ..These data demonstrate that FGF/FGFR1alpha signals are posteriorizing factors that control node regression and posterior embryonic development. ..
  18. Wahlström A, Kovatcheva Datchary P, Ståhlman M, Khan M, Backhed F, Marschall H. Induction of farnesoid X receptor signaling in germ-free mice colonized with a human microbiota. J Lipid Res. 2017;58:412-419 pubmed publisher
    ..microbiota was able to reduce the levels of tauro-β-muricholic acid and induce expression of FXR target genes Fgf15 and Shp in ileum after long-term colonization...
  19. Jadhav A, Mason H, Cepko C. Notch 1 inhibits photoreceptor production in the developing mammalian retina. Development. 2006;133:913-23 pubmed
    ..These cone enriched mutant mice should prove to be a valuable resource for the study of this relatively rare mammalian photoreceptor cell type. ..
  20. Du W, Prochazka J, Prochazkova M, Klein O. Expression of FGFs during early mouse tongue development. Gene Expr Patterns. 2016;20:81-7 pubmed publisher
    ..5 and E14.5. During this period, Fgf5, Fgf6, Fgf7, Fgf9, Fgf10, Fgf13, Fgf15, Fgf16 and Fgf18 could all be detected with various intensities in the mesenchyme, whereas Fgf1 and Fgf2 were ..
  21. Kong B, Huang J, Zhu Y, Li G, Williams J, Shen S, et al. Fibroblast growth factor 15 deficiency impairs liver regeneration in mice. Am J Physiol Gastrointest Liver Physiol. 2014;306:G893-902 pubmed publisher
    Fibroblast growth factor (FGF) 15 (human homolog, FGF19) is an endocrine FGF highly expressed in the small intestine of mice...
  22. Kir S, Zhang Y, Gerard R, Kliewer S, Mangelsdorf D. Nuclear receptors HNF4? and LRH-1 cooperate in regulating Cyp7a1 in vivo. J Biol Chem. 2012;287:41334-41 pubmed publisher
    Fibroblast growth factor 19 (FGF19) is a postprandial enterokine induced by the nuclear bile acid receptor, FXR, in ileum...
  23. Garcia C, Huang J, Madakashira B, Liu Y, Rajagopal R, Dattilo L, et al. The function of FGF signaling in the lens placode. Dev Biol. 2011;351:176-85 pubmed publisher
    ..Since the expression of proteins required for lens formation was not altered in the knockout placode cells, we can conclude that FGF signaling from the optic vesicle is not required for lens induction. ..
  24. Abraira V, Hyun N, Tucker A, Coling D, Brown M, Lu C, et al. Changes in Sef levels influence auditory brainstem development and function. J Neurosci. 2007;27:4273-82 pubmed
    ..Sef is expressed immediately adjacent to the rhombic lip, overlapping with FGF15 and FGFR1, which is also present in the lip itself...
  25. Gimeno L, Martinez S. Expression of chick Fgf19 and mouse Fgf15 orthologs is regulated in the developing brain by Fgf8 and Shh. Dev Dyn. 2007;236:2285-97 pubmed
    ..We have studied the expression pattern of mouse Fgf15 in the developing brain. Fgf19 is another member of the FGF family that has been suggested as the chick and human ortholog of mouse and rat Fgf15...
  26. Picard A, Soyer J, Berney X, Tarussio D, Quenneville S, Jan M, et al. A Genetic Screen Identifies Hypothalamic Fgf15 as a Regulator of Glucagon Secretion. Cell Rep. 2016;17:1795-1806 pubmed publisher
    ..Intracerebroventricular injection of FGF19, the human ortholog of Fgf15, reduced activation by neuroglucopenia of dorsal vagal complex neurons, of the ..
  27. Parchem R, Moore N, Fish J, Parchem J, Braga T, Shenoy A, et al. miR-302 Is Required for Timing of Neural Differentiation, Neural Tube Closure, and Embryonic Viability. Cell Rep. 2015;12:760-73 pubmed publisher
    ..Overexpression of one of these targets, Fgf15, in the neuroepithelium of the chick embryo induces precocious neuronal differentiation...
  28. Shin D, Osborne T. FGF15/FGFR4 integrates growth factor signaling with hepatic bile acid metabolism and insulin action. J Biol Chem. 2009;284:11110-20 pubmed publisher
    The current studies show FGF15 signaling decreases hepatic forkhead transcription factor 1 (FoxO1) activity through phosphatidylinositol (PI) 3-kinase-dependent phosphorylation...
  29. Zhou M, Luo J, Chen M, Yang H, Learned R, Depaoli A, et al. Mouse species-specific control of hepatocarcinogenesis and metabolism by FGF19/FGF15. J Hepatol. 2017;66:1182-1192 pubmed publisher
    ..In this report, we compared the properties of human FGF19 and murine FGF15 in the regulation of hepatocarcinogenesis and metabolism in various mouse models of disease...
  30. Krizhanovsky V, Soreq L, Kliminski V, Ben Arie N. Math1 target genes are enriched with evolutionarily conserved clustered E-box binding sites. J Mol Neurosci. 2006;28:211-29 pubmed
    ..Our findings may be useful to the study of other bHLH transcription factors, many of which control the development of the nervous system. ..
  31. Luo J, Ko B, Elliott M, Zhou M, Lindhout D, Phung V, et al. A nontumorigenic variant of FGF19 treats cholestatic liver diseases. Sci Transl Med. 2014;6:247ra100 pubmed publisher
    ..Endocrine hormone fibroblast growth factor 19 (FGF19) may reduce hepatic bile acid levels through modulation of bile acid synthesis and prevent subsequent liver damage...
  32. Saitsu H, Shiota K, Ishibashi M. Analysis of Fibroblast growth factor 15 cis-elements reveals two conserved enhancers which are closely related to cardiac outflow tract development. Mech Dev. 2006;123:665-73 pubmed
    b>Fibroblast growth factor 15 (Fgf15) is expressed in the developing mouse central nervous system and pharyngeal arches...
  33. Han S, Han S, Zhang R, Jain R, Shi H, Zhang L, et al. Circadian control of bile acid synthesis by a KLF15-Fgf15 axis. Nat Commun. 2015;6:7231 pubmed publisher
    ..Here we identify a KLF15-Fgf15 signalling axis that regulates circadian BA production...
  34. Zhu Y, Ding X, Fang C, Zhang Q. Regulation of intestinal cytochrome P450 expression by hepatic cytochrome P450: possible involvement of fibroblast growth factor 15 and impact on systemic drug exposure. Mol Pharmacol. 2014;85:139-47 pubmed publisher
    ..intestine, plasma, and intestinal content, led to drastic decreases in the mRNA levels of intestinal fibroblast growth factor 15 (FGF15), a target gene of the BA receptor farnesoid X receptor...
  35. Morton G, Matsen M, Bracy D, Meek T, Nguyen H, Stefanovski D, et al. FGF19 action in the brain induces insulin-independent glucose lowering. J Clin Invest. 2013;123:4799-808 pubmed
    ..The gut-derived hormone FGF19 has previously been shown to exert potent antidiabetic effects in ob/ob mice...
  36. Vázquez Echeverría C, Dominguez Frutos E, Charnay P, Schimmang T, Pujades C. Analysis of mouse kreisler mutants reveals new roles of hindbrain-derived signals in the establishment of the otic neurogenic domain. Dev Biol. 2008;322:167-78 pubmed publisher
    ..These results highlight the importance of hindbrain-derived signals in the regulation of otic neurogenesis. ..
  37. Jahn D, Sutor D, Dorbath D, Weiß J, Götze O, Schmitt J, et al. Farnesoid X receptor-dependent and -independent pathways mediate the transcriptional control of human fibroblast growth factor 19 by vitamin A. Biochim Biophys Acta. 2016;1859:381-92 pubmed publisher
    Fibroblast growth factor 19 (FGF19) is a gut-derived hormone that controls bile acid (BA), carbohydrate and lipid metabolism...
  38. Lien W, Klezovitch O, Fernandez T, Delrow J, Vasioukhin V. alphaE-catenin controls cerebral cortical size by regulating the hedgehog signaling pathway. Science. 2006;311:1609-12 pubmed
    ..We propose that alphaE-catenin connects cell-density-dependent adherens junctions with the developmental hedgehog pathway and that this connection may provide a negative feedback loop controlling the size of developing cerebral cortex. ..
  39. Cunningham T, Colas A, Duester G. Early molecular events during retinoic acid induced differentiation of neuromesodermal progenitors. Biol Open. 2016;5:1821-1833 pubmed publisher
    ..Raldh2-/- embryos identified novel examples of RA activation (Nkx1-2, Zfp503, Zfp703, Gbx2, Fgf15, Nt5e) or RA repression (Id1) of genes expressed in the NMP niche or progeny...
  40. Zhou X, Cao L, Jiang C, Xie Y, Cheng X, Krausz K, et al. PPARα-UGT axis activation represses intestinal FXR-FGF15 feedback signalling and exacerbates experimental colitis. Nat Commun. 2014;5:4573 pubmed publisher
    ..Both knockout of PPARα and treatment with recombinant FGF19 markedly attenuate DSS-induced colitis...
  41. Schumacher J, Kong B, Pan Y, Zhan L, Sun R, Aa J, et al. The effect of fibroblast growth factor 15 deficiency on the development of high fat diet induced non-alcoholic steatohepatitis. Toxicol Appl Pharmacol. 2017;330:1-8 pubmed publisher
    ..b>Fibroblast growth factor 15 (FGF15), an endocrine factor mainly produced in the distal part of small intestine, has emerged to be a ..
  42. Takase H, Itoh T, Ino S, Wang T, Koji T, Akira S, et al. FGF7 is a functional niche signal required for stimulation of adult liver progenitor cells that support liver regeneration. Genes Dev. 2013;27:169-81 pubmed publisher
    ..These findings provide new insights into the cellular and molecular basis for LPC regulation and identify FGF7 as a potential therapeutic target for liver diseases. ..
  43. Marcos S, González Lázaro M, Beccari L, Carramolino L, Martín Bermejo M, Amarie O, et al. Meis1 coordinates a network of genes implicated in eye development and microphthalmia. Development. 2015;142:3009-20 pubmed publisher
    ..We propose that Meis1 is at the core of a genetic network implicated in eye patterning/microphthalmia, and represents an additional candidate for syndromic cases of these ocular malformations. ..
  44. Saitsu H, Komada M, Suzuki M, Nakayama R, Motoyama J, Shiota K, et al. Expression of the mouse Fgf15 gene is directly initiated by Sonic hedgehog signaling in the diencephalon and midbrain. Dev Dyn. 2005;232:282-92 pubmed
    ..In the previous genetic study, we showed that Shh is required for Fgf15 expression in the diencephalon and midbrain...
  45. Komada M, Saitsu H, Shiota K, Ishibashi M. Expression of Fgf15 is regulated by both activator and repressor forms of Gli2 in vitro. Biochem Biophys Res Commun. 2008;369:350-6 pubmed publisher
    b>Fibroblast growth factor 15 (Fgf15) is expressed in the medial region of diencephalon and midbrain by the seven-somite stage...
  46. Sinha J, Chen F, Miloh T, Burns R, Yu Z, Shneider B. beta-Klotho and FGF-15/19 inhibit the apical sodium-dependent bile acid transporter in enterocytes and cholangiocytes. Am J Physiol Gastrointest Liver Physiol. 2008;295:G996-G1003 pubmed publisher
    ..These results indicate that both beta-Klotho and FGF-15/19 repress ASBT in enterocytes and cholangiocytes. These novel signaling pathways need to be considered in analyzing bile acid homeostasis. ..
  47. Wright T, Ladher R, McWhirter J, Murre C, Schoenwolf G, Mansour S. Mouse FGF15 is the ortholog of human and chick FGF19, but is not uniquely required for otic induction. Dev Biol. 2004;269:264-75 pubmed
    ..fibroblast growth factor (Fgf)-19 is expressed in mesoderm underlying the presumptive otic placode, and human FGF19 induces expression of otic markers in a tissue explant containing neural plate and surface ectoderm...
  48. Gardiner J, Jackson A, Gordon J, Lickert H, Manley N, Basson M. Localised inhibition of FGF signalling in the third pharyngeal pouch is required for normal thymus and parathyroid organogenesis. Development. 2012;139:3456-66 pubmed publisher
  49. Lan T, Rao A, Haywood J, Kock N, Dawson P. Mouse organic solute transporter alpha deficiency alters FGF15 expression and bile acid metabolism. J Hepatol. 2012;57:359-65 pubmed publisher
    ..the mechanisms underlying this phenotype, including the role of the farnesoid X receptor (FXR) and fibroblast growth factor 15 (FGF15)...
  50. Trokovic R, Jukkola T, Saarimäki J, Peltopuro P, Naserke T, Weisenhorn D, et al. Fgfr1-dependent boundary cells between developing mid- and hindbrain. Dev Biol. 2005;278:428-39 pubmed
    ..The slowly proliferating boundary cells are necessary for development of the characteristic isthmic constriction. They may also contribute to compartmentalization of this brain region. ..
  51. Vincentz J, McWhirter J, Murre C, Baldini A, Furuta Y. Fgf15 is required for proper morphogenesis of the mouse cardiac outflow tract. Genesis. 2005;41:192-201 pubmed
    ..Here, we describe the phenotype of mice lacking fibroblast growth factor 15 (Fgf15), which encodes a secreted signaling molecule expressed within the developing pharyngeal arches...
  52. Gimeno L, Hashemi R, Brulet P, Martinez S. Analysis of Fgf15 expression pattern in the mouse neural tube. Brain Res Bull. 2002;57:297-9 pubmed
    ..Here we analyze the expression of Fgf15 at different stages of mouse development in relation to Fgf8 and Otx2 expression patterns.
  53. Byun S, Kim Y, Zhang Y, Kong B, Guo G, Sadoshima J, et al. A postprandial FGF19-SHP-LSD1 regulatory axis mediates epigenetic repression of hepatic autophagy. EMBO J. 2017;36:1755-1769 pubmed publisher
    ..repression of hepatic autophagy by recruiting histone demethylase LSD1 in response to a late fed-state hormone, FGF19 (hFGF19, mFGF15)...
  54. Lan T, Haywood J, Dawson P. Inhibition of ileal apical but not basolateral bile acid transport reduces atherosclerosis in apoE⁻/⁻ mice. Atherosclerosis. 2013;229:374-80 pubmed publisher
    ..Ileal Fibroblast Growth Factor-15 (FGF15) expression was significantly reduced in Asbt(-/-)apoE(-/-) mice and was inversely correlated with expression of ..
  55. Rash B, Grove E. Shh and Gli3 regulate formation of the telencephalic-diencephalic junction and suppress an isthmus-like signaling source in the forebrain. Dev Biol. 2011;359:242-50 pubmed publisher
    ..That optional signaling centers are actively repressed in normal development is a striking new insight into the processes of vertebrate brain development. ..
  56. Uriarte I, Latasa M, Carotti S, Fernández Barrena M, Garcia Irigoyen O, Elizalde M, et al. Ileal FGF15 contributes to fibrosis-associated hepatocellular carcinoma development. Int J Cancer. 2015;136:2469-75 pubmed publisher
    b>Fibroblast growth factor 15 (FGF15), FGF19 in humans, is a gut-derived hormone and a key regulator of bile acids and carbohydrate metabolism...
  57. Behesti H, Papaioannou V, Sowden J. Loss of Tbx2 delays optic vesicle invagination leading to small optic cups. Dev Biol. 2009;333:360-72 pubmed publisher
    ..The small retina showed a hypocellular ventral region, loss of Fgf15, normally expressed in proliferating central retinal cells, and increased numbers of mitotic cells in the dorsal ..
  58. Vergnes L, Lee J, Chin R, Auwerx J, Reue K. Diet1 functions in the FGF15/19 enterohepatic signaling axis to modulate bile acid and lipid levels. Cell Metab. 2013;17:916-28 pubmed publisher
    ..intestine and in cultured human intestinal cells, Diet1 expression levels influenced the production of fibroblast growth factor 15/19 (FGF15/19), a hormone that signals from the intestine to liver to regulate Cyp7a1...
  59. Katayama K, Melendez J, Baumann J, Leslie J, Chauhan B, Nemkul N, et al. Loss of RhoA in neural progenitor cells causes the disruption of adherens junctions and hyperproliferation. Proc Natl Acad Sci U S A. 2011;108:7607-12 pubmed publisher
    ..These results demonstrate a critical role of RhoA in the maintenance of apical adherens junctions and the regulation of neural progenitor proliferation in the developing mammalian brain...
  60. Aldinger K, Lehmann O, Hudgins L, Chizhikov V, Bassuk A, Ades L, et al. FOXC1 is required for normal cerebellar development and is a major contributor to chromosome 6p25.3 Dandy-Walker malformation. Nat Genet. 2009;41:1037-42 pubmed publisher
    ..Our results highlight a previously unrecognized role for mesenchyme-neuroepithelium interactions in the mid-hindbrain during early embryogenesis...
  61. Trokovic N, Trokovic R, Partanen J. Fibroblast growth factor signalling and regional specification of the pharyngeal ectoderm. Int J Dev Biol. 2005;49:797-805 pubmed
    ..This appears to result in a failure to establish an ectodermal signalling center expressing Fgf3 and Fgf15. We also studied differentiation of the ectoderm in the second branchial arch region...
  62. Stroeve J, Brufau G, Stellaard F, Gonzalez F, Staels B, Kuipers F. Intestinal FXR-mediated FGF15 production contributes to diurnal control of hepatic bile acid synthesis in mice. Lab Invest. 2010;90:1457-67 pubmed publisher
    ..nuclear receptor farnesoid X receptor (FXR) in liver and intestine-derived, FXR-controlled fibroblast growth factor 15 (Fgf15) are involved...
  63. Yang C, Jin C, Li X, Wang F, McKeehan W, Luo Y. Differential specificity of endocrine FGF19 and FGF21 to FGFR1 and FGFR4 in complex with KLB. PLoS ONE. 2012;7:e33870 pubmed publisher
    Recent studies suggest that betaKlotho (KLB) and endocrine FGF19 and FGF21 redirect FGFR signaling to regulation of metabolic homeostasis and suppression of obesity and diabetes...
  64. Vendrell V, Vázquez Echeverría C, López Hernández I, Alonso B, Martinez S, Pujades C, et al. Roles of Wnt8a during formation and patterning of the mouse inner ear. Mech Dev. 2013;130:160-8 pubmed publisher
    ..Interestingly however, Wnt8a and Fgf3 are redundantly required for expression of Fgf15 in the hindbrain indicating additional reciprocal interactions between Fgf and Wnt signalling...
  65. Jones S. Physiology of FGF15/19. Adv Exp Med Biol. 2012;728:171-82 pubmed publisher
    This chapter will review the various biological actions of the mouse fibroblast growth factor 15 (Fgf15) and human fibroblast growth factor 19 (FGF19)...
  66. Bachler M, Neubüser A. Expression of members of the Fgf family and their receptors during midfacial development. Mech Dev. 2001;100:313-6 pubmed
    ..5. In contrast to the restricted expression patterns of the ligands, FgfR1 and FgfR2 were broadly expressed in facial mesenchyme and ectoderm, respectively, indicating a wide competence of midfacial tissue to respond to FGF signaling. ..
  67. Burns C, Zhang J, Brown E, Van Bibber A, van Es J, Clevers H, et al. Investigation of Frizzled-5 during embryonic neural development in mouse. Dev Dyn. 2008;237:1614-26 pubmed publisher
    ..Thus, the function of Fzd5 during eye development appears to be species-dependent. ..
  68. Goldman D, Martin G, Tam P. Fate and function of the ventral ectodermal ridge during mouse tail development. Development. 2000;127:2113-23 pubmed
  69. Hajihosseini M, Heath J. Expression patterns of fibroblast growth factors-18 and -20 in mouse embryos is suggestive of novel roles in calvarial and limb development. Mech Dev. 2002;113:79-83 pubmed
  70. de Melo J, Zibetti C, Clark B, Hwang W, Miranda Angulo A, Qian J, et al. Lhx2 Is an Essential Factor for Retinal Gliogenesis and Notch Signaling. J Neurosci. 2016;36:2391-405 pubmed publisher
    ..These results indicate that Lhx2 not only directly regulates expression of Notch signaling pathway components, but also acts together with the gliogenic Notch pathway to drive MG specification and differentiation. ..
  71. Martinez Ferre A, Lloret Quesada C, Prakash N, Wurst W, Rubenstein J, Martinez S. Fgf15 regulates thalamic development by controlling the expression of proneural genes. Brain Struct Funct. 2016;221:3095-109 pubmed publisher
    ..Fgf15, the mouse gene orthologous of human, chick, and zebrafish Fgf19, is induced by Shh signal and expressed in the diencephalic alar plate progenitors during histogenetic ..
  72. Naugler W, Tarlow B, Fedorov L, Taylor M, Pelz C, Li B, et al. Fibroblast Growth Factor Signaling Controls Liver Size in Mice With Humanized Livers. Gastroenterology. 2015;149:728-40.e15 pubmed publisher
    ..We inserted the gene for human FGF19 (ortholog to mouse Fgf15), including regulatory sequences, into the FRGN mice to create FRGN19(+) mice...
  73. Slijepcevic D, Roscam Abbing R, Katafuchi T, Blank A, Donkers J, Van Hoppe S, et al. Hepatic uptake of conjugated bile acids is mediated by both sodium taurocholate cotransporting polypeptide and organic anion transporting polypeptides and modulated by intestinal sensing of plasma bile acid levels in mice. Hepatology. 2017;66:1631-1643 pubmed publisher
    ..b>Fgf15 (mouse counterpart of FGF19) expression was induced in hypercholanemic OATP and NTCP knockout mice, as well as in ..