Gene Symbol: Fgf13
Description: fibroblast growth factor 13
Alias: Fhf2, fibroblast growth factor 13, fibroblast growth factor homologous factor 2
Species: mouse
Products:     Fgf13

Top Publications

  1. Hoffman M, Kidder B, Steinberg Z, Lakhani S, Ho S, Kleinman H, et al. Gene expression profiles of mouse submandibular gland development: FGFR1 regulates branching morphogenesis in vitro through BMP- and FGF-dependent mechanisms. Development. 2002;129:5767-78 pubmed
    ..Taken together, our results suggest specific FGFs and BMPs play reciprocal roles in regulating branching morphogenesis and FGFR1 signaling plays a central role by regulating both FGF and BMP expression. ..
  2. Wright T, Hatch E, Karabagli H, Karabagli P, Schoenwolf G, Mansour S. Expression of mouse fibroblast growth factor and fibroblast growth factor receptor genes during early inner ear development. Dev Dyn. 2003;228:267-72 pubmed
    ..Fgf16 was expressed in the posterior otic cup and vesicle, suggesting roles in otic cell fate decisions and/or axis formation. ..
  3. Hennessey J, Wei E, Pitt G. Fibroblast growth factor homologous factors modulate cardiac calcium channels. Circ Res. 2013;113:381-8 pubmed publisher
    ..Affinity purification of FGF13 from rodent ventricular lysates followed by mass spectroscopy revealed an interaction with junctophilin-2, a ..
  4. Burel S, Coyan F, Lorenzini M, Meyer M, Lichti C, BROWN J, et al. C-terminal phosphorylation of NaV1.5 impairs FGF13-dependent regulation of channel inactivation. J Biol Chem. 2017;292:17431-17448 pubmed publisher
    ..We then tested the hypothesis that phosphorylation at these two sites impairs fibroblast growth factor 13 (FGF13)-dependent regulation of NaV1.5 channel inactivation...
  5. Munoz Sanjuan I, Smallwood P, Nathans J. Isoform diversity among fibroblast growth factor homologous factors is generated by alternative promoter usage and differential splicing. J Biol Chem. 2000;275:2589-97 pubmed
  6. Bachler M, Neub├╝ser A. Expression of members of the Fgf family and their receptors during midfacial development. Mech Dev. 2001;100:313-6 pubmed
    ..5. In contrast to the restricted expression patterns of the ligands, FgfR1 and FgfR2 were broadly expressed in facial mesenchyme and ectoderm, respectively, indicating a wide competence of midfacial tissue to respond to FGF signaling. ..
  7. Lu H, Shi X, Wu G, Zhu J, Song C, Zhang Q, et al. FGF13 regulates proliferation and differentiation of skeletal muscle by down-regulating Spry1. Cell Prolif. 2015;48:550-60 pubmed publisher
    ..Intracellular FGFs (FGF11-14) are expressed principally in the nervous system. FGF13 is a microtubule-stabilizing protein that regulates neuronal polarization and migration...
  8. Hajihosseini M, Heath J. Expression patterns of fibroblast growth factors-18 and -20 in mouse embryos is suggestive of novel roles in calvarial and limb development. Mech Dev. 2002;113:79-83 pubmed
  9. Dykes I, Tempest L, Lee S, Turner E. Brn3a and Islet1 act epistatically to regulate the gene expression program of sensory differentiation. J Neurosci. 2011;31:9789-99 pubmed publisher

More Information


  1. Smallwood P, Munoz Sanjuan I, Tong P, Macke J, Hendry S, Gilbert D, et al. Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development. Proc Natl Acad Sci U S A. 1996;93:9850-7 pubmed
    ..Each FHF is expressed in the developing and adult nervous systems, suggesting a role for this branch of the FGF family in nervous system development and function. ..
  2. Hartung H, Feldman B, Lovec H, Coulier F, Birnbaum D, Goldfarb M. Murine FGF-12 and FGF-13: expression in embryonic nervous system, connective tissue and heart. Mech Dev. 1997;64:31-9 pubmed
    ..Fgf12 and fgf13. RNAs were detected in developing central nervous system in cells outside the proliferating ependymal layer, and ..
  3. Puranam R, He X, Yao L, Le T, Jang W, Rehder C, et al. Disruption of Fgf13 causes synaptic excitatory-inhibitory imbalance and genetic epilepsy and febrile seizures plus. J Neurosci. 2015;35:8866-81 pubmed publisher
    ..on the X chromosome disrupted a gene that encodes an auxiliary protein of voltage-gated Na(+) channels, fibroblast growth factor 13 (Fgf13)...
  4. Du W, Prochazka J, Prochazkova M, Klein O. Expression of FGFs during early mouse tongue development. Gene Expr Patterns. 2016;20:81-7 pubmed publisher
    ..5 and E14.5. During this period, Fgf5, Fgf6, Fgf7, Fgf9, Fgf10, Fgf13, Fgf15, Fgf16 and Fgf18 could all be detected with various intensities in the mesenchyme, whereas Fgf1 and Fgf2 ..
  5. Wang X, Tang H, Wei E, Wang Z, Yang J, Yang R, et al. Conditional knockout of Fgf13 in murine hearts increases arrhythmia susceptibility and reveals novel ion channel modulatory roles. J Mol Cell Cardiol. 2017;104:63-74 pubmed publisher
    ..We generated inducible, cardiomyocyte-restricted Fgf13 knockout mice to determine the resultant effects of Fgf13 gene ablation...
  6. Wu Q, Yang L, Li S, Wang Q, Yuan X, Gao X, et al. Fibroblast growth factor 13 is a microtubule-stabilizing protein regulating neuronal polarization and migration. Cell. 2012;149:1549-64 pubmed publisher
    ..b>FGF13, a nonsecretory protein of the FGF family, is expressed in cerebral cortical neurons during development and is a ..
  7. Dover K, Solinas S, D Angelo E, Goldfarb M. Long-term inactivation particle for voltage-gated sodium channels. J Physiol. 2010;588:3695-711 pubmed publisher
    ..We discuss potential structural mechanisms of long-term inactivation and potential roles of A-type FHFs in the modulation of action potential generation and conduction. ..
  8. Heanue T, Pachnis V. Ret isoform function and marker gene expression in the enteric nervous system is conserved across diverse vertebrate species. Mech Dev. 2008;125:687-99 pubmed publisher
  9. Wang C, Hennessey J, Kirkton R, Wang C, Graham V, Puranam R, et al. Fibroblast growth factor homologous factor 13 regulates Na+ channels and conduction velocity in murine hearts. Circ Res. 2011;109:775-82 pubmed publisher
    ..We tested whether FHFs regulate Na(+) channels in murine heart. We demonstrated that isoforms of FGF13 are the predominant FHFs in adult mouse ventricular myocytes...
  10. Destefano G, Fantauzzo K, Petukhova L, Kurban M, Tadin Strapps M, Levy B, et al. Position effect on FGF13 associated with X-linked congenital generalized hypertrichosis. Proc Natl Acad Sci U S A. 2013;110:7790-5 pubmed publisher
    ..Among the genes surrounding the insertion, we found that Fibroblast Growth Factor 13 (FGF13) mRNA levels were significantly reduced in affected individuals, and immunofluorescence staining ..
  11. Kawano M, Suzuki S, Suzuki M, Oki J, Imamura T. Bulge- and basal layer-specific expression of fibroblast growth factor-13 (FHF-2) in mouse skin. J Invest Dermatol. 2004;122:1084-90 pubmed
    ..These findings suggest that FGF-13 may play a role in regulating the function of cells in the bulge region and basal layer of the epidermis. ..
  12. Elliott R, Miller D, Pearsall R, Hohman C, Zhang Y, Poslinski D, et al. Genetic analysis of testis weight and fertility in an interspecies hybrid congenic strain for Chromosome X. Mamm Genome. 2001;12:45-51 pubmed
    ..8 map units for Ihtw1. This region of the genetic map is orthologous to the region on human Chr X containing the gene for the Borjeson-Forssman-Lehman syndrome, an inherited disease in which males show microorchidism. ..
  13. Yang L, Dong F, Yang Q, Yang P, Wu R, Wu Q, et al. FGF13 Selectively Regulates Heat Nociception by Interacting with Nav1.7. Neuron. 2017;93:806-821.e9 pubmed publisher
    ..We found that the loss of an intracellular fibroblast growth factor (FGF), FGF13, in the mouse DRG neurons selectively abolished heat nociception...
  14. Pablo J, Wang C, Presby M, Pitt G. Polarized localization of voltage-gated Na+ channels is regulated by concerted FGF13 and FGF14 action. Proc Natl Acad Sci U S A. 2016;113:E2665-74 pubmed publisher
    ..Here, using knockdown strategies, we show that noncanonical FGF13 binds directly to VGSCs in hippocampal neurons to limit their somatodendritic surface expression, although ..