Fgf10

Summary

Gene Symbol: Fgf10
Description: fibroblast growth factor 10
Alias: AEY17, BB213776, Fgf-10, Gsfaey17, keratinocyte growth factor 2
Species: mouse

Top Publications

  1. ncbi Fibroblast growth factor 10 (FGF10) and branching morphogenesis in the embryonic mouse lung
    S Bellusci
    Department of Cell Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2175, USA
    Development 124:4867-78. 1997
  2. ncbi The arterial pole of the mouse heart forms from Fgf10-expressing cells in pharyngeal mesoderm
    R G Kelly
    Departement de Biologie Moleculaire, Institut Pasteur, Paris, France
    Dev Cell 1:435-40. 2001
  3. ncbi Role of FGF10/FGFR2b signaling during mammary gland development in the mouse embryo
    Arnaud André Mailleux
    UMR144 CNRS Institut Curie, 26 rue d Ulm 75248 Paris Cedex 05, France
    Development 129:53-60. 2002
  4. pmc Fgf-10 is required for both limb and lung development and exhibits striking functional similarity to Drosophila branchless
    H Min
    Department of Molecular Genetics, Amgen, Inc, Thousand Oaks, California 91320 1789 USA
    Genes Dev 12:3156-61. 1998
  5. ncbi T-box gene products are required for mesenchymal induction of epithelial branching in the embryonic mouse lung
    Judith A Cebra-Thomas
    Department of Biology, Franklin and Marshall College, Lancaster, Pennsylvania, USA
    Dev Dyn 226:82-90. 2003
  6. pmc FGF10 controls the patterning of the tracheal cartilage rings via Shh
    Frederic G Sala
    Developmental Biology and Regenerative Medicine Program, Saban Research Institute of Childrens Hospital Los Angeles, Los Angeles, CA 90027, USA
    Development 138:273-82. 2011
  7. ncbi Fgf10 expression identifies parabronchial smooth muscle cell progenitors and is required for their entry into the smooth muscle cell lineage
    Arnaud A Mailleux
    UMR144 CNRS Institut Curie, 75248 Paris Cedex 05, France
    Development 132:2157-66. 2005
  8. ncbi Growth arrest specific gene 1 acts as a region-specific mediator of the Fgf10/Fgf8 regulatory loop in the limb
    Ying Liu
    Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland 21210, USA
    Development 129:5289-300. 2002
  9. ncbi Tbx1 has a dual role in the morphogenesis of the cardiac outflow tract
    Huansheng Xu
    Program in Cardiovascular Sciences, Baylor College of Medicine, Houston, TX 77030, USA
    Development 131:3217-27. 2004
  10. ncbi Gli3-mediated somitic Fgf10 expression gradients are required for the induction and patterning of mammary epithelium along the embryonic axes
    Jacqueline M Veltmaat
    The Saban Research Institute of Childrens Hospital Los Angeles University of Southern California, Developmental Biology Program, Los Angeles, CA 90027, USA
    Development 133:2325-35. 2006

Scientific Experts

Detail Information

Publications150 found, 100 shown here

  1. ncbi Fibroblast growth factor 10 (FGF10) and branching morphogenesis in the embryonic mouse lung
    S Bellusci
    Department of Cell Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2175, USA
    Development 124:4867-78. 1997
    ..We report here that fibroblast growth factor 10 (Fgf10) is expressed dynamically in the mesenchyme adjacent to the distal buds from the earliest stages of lung ..
  2. ncbi The arterial pole of the mouse heart forms from Fgf10-expressing cells in pharyngeal mesoderm
    R G Kelly
    Departement de Biologie Moleculaire, Institut Pasteur, Paris, France
    Dev Cell 1:435-40. 2001
    ..The nlacZ transgene has integrated upstream of the fibroblast growth factor 10 (Fgf10) gene and comparison with the expression pattern of Fgf10 in pharyngeal mesoderm indicates transgene control by ..
  3. ncbi Role of FGF10/FGFR2b signaling during mammary gland development in the mouse embryo
    Arnaud André Mailleux
    UMR144 CNRS Institut Curie, 26 rue d Ulm 75248 Paris Cedex 05, France
    Development 129:53-60. 2002
    ..placode development using Lef1 as a marker for the epithelial component of the placode, and mice deficient for Fgf10 or Fgfr2b, both of which fail to develop normal mammary glands...
  4. pmc Fgf-10 is required for both limb and lung development and exhibits striking functional similarity to Drosophila branchless
    H Min
    Department of Molecular Genetics, Amgen, Inc, Thousand Oaks, California 91320 1789 USA
    Genes Dev 12:3156-61. 1998
    ..The pulmonary phenotype of Fgf-10(-/-) mice is strikingly similar to that of the Drosophila mutant branchless, an Fgf homolog...
  5. ncbi T-box gene products are required for mesenchymal induction of epithelial branching in the embryonic mouse lung
    Judith A Cebra-Thomas
    Department of Biology, Franklin and Marshall College, Lancaster, Pennsylvania, USA
    Dev Dyn 226:82-90. 2003
    ..Mesenchymal FGF10 is known to be an important paracrine factor regulating the branching morphogenesis of the bronchial epithelium...
  6. pmc FGF10 controls the patterning of the tracheal cartilage rings via Shh
    Frederic G Sala
    Developmental Biology and Regenerative Medicine Program, Saban Research Institute of Childrens Hospital Los Angeles, Los Angeles, CA 90027, USA
    Development 138:273-82. 2011
    ..Using a combination of gain- and loss-of-function approaches for FGF10 and SHH, we demonstrate that precise spatio-temporal patterns and appropriate levels of expression of these two ..
  7. ncbi Fgf10 expression identifies parabronchial smooth muscle cell progenitors and is required for their entry into the smooth muscle cell lineage
    Arnaud A Mailleux
    UMR144 CNRS Institut Curie, 75248 Paris Cedex 05, France
    Development 132:2157-66. 2005
    ..Using a transgenic mouse line expressing LacZ under the control of Fgf10 regulatory sequences, we show that the pool of Fgf10-positive cells in the distal lung mesenchyme contains ..
  8. ncbi Growth arrest specific gene 1 acts as a region-specific mediator of the Fgf10/Fgf8 regulatory loop in the limb
    Ying Liu
    Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland 21210, USA
    Development 129:5289-300. 2002
    Proximal-to-distal growth of the embryonic limbs requires Fgf10 in the mesenchyme to activate Fgf8 in the apical ectodermal ridge (AER), which in turn promotes mesenchymal outgrowth...
  9. ncbi Tbx1 has a dual role in the morphogenesis of the cardiac outflow tract
    Huansheng Xu
    Program in Cardiovascular Sciences, Baylor College of Medicine, Houston, TX 77030, USA
    Development 131:3217-27. 2004
    ..This process might be regulated in part by Fgf10, which we show for the first time to be a direct target of Tbx1 in vitro...
  10. ncbi Gli3-mediated somitic Fgf10 expression gradients are required for the induction and patterning of mammary epithelium along the embryonic axes
    Jacqueline M Veltmaat
    The Saban Research Institute of Childrens Hospital Los Angeles University of Southern California, Developmental Biology Program, Los Angeles, CA 90027, USA
    Development 133:2325-35. 2006
    ..We have previously shown that fibroblast growth factor 10 (FGF10) is required for the formation of mammary placodes 1, 2, 3 and 5...
  11. pmc Fgf10 dosage is critical for the amplification of epithelial cell progenitors and for the formation of multiple mesenchymal lineages during lung development
    Suresh K Ramasamy
    Developmental Biology Program, Saban Research Institute of Childrens Hospital Los Angeles, Los Angeles, CA 90027, USA
    Dev Biol 307:237-47. 2007
    The key role played by Fgf10 during early lung development is clearly illustrated in Fgf10 knockout mice, which exhibit lung agenesis...
  12. pmc Fibroblast growth factor 10 plays a causative role in the tracheal cartilage defects in a mouse model of Apert syndrome
    Caterina Tiozzo
    Department of Pediatrics, Women s and Children s Hospital, University of Southern California Keck School of Medicine, Los Angeles, California 90033, USA
    Pediatr Res 66:386-90. 2009
    ..that tracheal stenosis is associated with increased proliferation of mesenchymal cells, where the expression of Fgf10 and its upstream regulators Tbx4 and Tbx5 are abnormally elevated...
  13. pmc FGF signaling regulates otic placode induction and refinement by controlling both ectodermal target genes and hindbrain Wnt8a
    Lisa D Urness
    Department of Human Genetics, University of Utah, 15 N 2030 E, RM 2100, Salt Lake City, UT 84112 5330, USA
    Dev Biol 340:595-604. 2010
    ..Mouse embryos lacking both Fgf3 and Fgf10 fail to initiate inner ear development because appropriate patterns of gene expression fail to be specified within ..
  14. pmc Retinoic acid deficiency alters second heart field formation
    Lucile Ryckebusch
    Developmental Biology Institute of Marseille Luminy, Centre National de la Recherche Scientifique Unité Mixte de Recherche 6216, Campus de Luminy Case 907, 13009 Marseille, France
    Proc Natl Acad Sci U S A 105:2913-8. 2008
    ..exhibited a posterior expansion of anterior markers of the SHF, including Tbx1, Fgf8, and the Mlc1v-nlacZ-24/Fgf10 reporter transgene as well as of Islet1...
  15. ncbi Tbx5 is essential for forelimb bud initiation following patterning of the limb field in the mouse embryo
    Pooja Agarwal
    Programmes in Cardiovascular Research and Developmental Biology, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada
    Development 130:623-33. 2003
    ..the FGF and Wnt regulatory loops required for limb bud outgrowth are not established, including initiation of Fgf10 expression...
  16. ncbi Fgf10 is essential for limb and lung formation
    K Sekine
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, Japan
    Nat Genet 21:138-41. 1999
    ..In particular, Fgf10 is predicted to function as a regulator of brain, lung and limb development on the basis of its spatiotemporal ..
  17. pmc Role of mesodermal FGF8 and FGF10 overlaps in the development of the arterial pole of the heart and pharyngeal arch arteries
    Yusuke Watanabe
    Department of Developmental Biology, URA CNRS 2578, Institut Pasteur, 25 rue du Dr Roux 75015 Paris, France
    Circ Res 106:495-503. 2010
    ..Previous studies of hypomorphic and conditional Fgf8 mutants show disrupted outflow tract (OFT) and right ventricle (RV) development, whereas Fgf10 mutants do not have detectable OFT defects.
  18. ncbi A genetic mechanism for cecal atresia: the role of the Fgf10 signaling pathway
    T J Fairbanks
    Developmental Biology Program, Children s Hospital Los Angeles, 4650 Sunset Boulevard, Smith Research Tower 804, Mail stop 100, Los Angeles, CA 90027, USA
    J Surg Res 120:201-9. 2004
    ..As the intestine differentiates, the cecum develops at the transition from small to large intestine. Fgf10 is known to serve a key role in budding morphogenesis; however, little is known about its role in the development ..
  19. pmc ISL1 directly regulates FGF10 transcription during human cardiac outflow formation
    Christelle Golzio
    Department of Cell Biology, Duke Medical Center, Durham, North Carolina, United States of America
    PLoS ONE 7:e30677. 2012
    ..Other markers have been identified that characterize subdomains of the SHF, such as the fibroblast growth factor Fgf10 in its anterior region...
  20. ncbi Associations of FGF-3 and FGF-10 with signaling networks regulating tooth morphogenesis
    P Kettunen
    Developmental Biology Programme, Institute of Biotechnology, Viikki Biocenter, University of Helsinki, Finland
    Dev Dyn 219:322-32. 2000
    ..The dynamic expression patterns of different Fgfs in dental epithelium and mesenchyme and their interactions suggest existence of regulatory signaling cascades between epithelial and mesenchymal FGFs during tooth development...
  21. pmc beta-Catenin promotes respiratory progenitor identity in mouse foregut
    Kelley S Harris-Johnson
    Laboratory of Genetics and Division of Pharmaceutical Sciences, University of Wisconsin Madison, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 106:16287-92. 2009
    ..Our findings reveal an early role for beta-Catenin in the establishment of respiratory progenitors in mouse foregut endoderm...
  22. pmc Conditional gene inactivation reveals roles for Fgf10 and Fgfr2 in establishing a normal pattern of epithelial branching in the mouse lung
    Lisa L Abler
    Laboratory of Genetics, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Dev Dyn 238:1999-2013. 2009
    Fibroblast growth factor 10 (FGF10) signaling through FGF receptor 2 (FGFR2) is required for lung initiation...
  23. pmc A splicing switch and gain-of-function mutation in FgfR2-IIIc hemizygotes causes Apert/Pfeiffer-syndrome-like phenotypes
    M K Hajihosseini
    Imperial Cancer Research Fund, 44 Lincoln s Inn Fields, London WC2A 3PX, United Kingdom
    Proc Natl Acad Sci U S A 98:3855-60. 2001
    ..This phenotype has strong parallels to some Apert's and Pfeiffer's syndrome patients...
  24. pmc An FGF signaling loop sustains the generation of differentiated progeny from stem cells in mouse incisors
    Ophir D Klein
    Department of Anatomy and Program in Developmental Biology, School of Medicine, University of California at San Francisco, San Francisco, CA 94143 2711, USA
    Development 135:377-85. 2008
    ..These data reveal that the generation of differentiated progeny from a particular stem cell population can be differently regulated in the embryo and adult...
  25. pmc Great vessel development requires biallelic expression of Chd7 and Tbx1 in pharyngeal ectoderm in mice
    Victoria Randall
    Molecular Medicine Unit, Institute of Child Health, London, United Kingdom
    J Clin Invest 119:3301-10. 2009
    ..We could not rescue PAA morphogenesis by restoring neural crest Chd7 expression. Rather, biallelic expression of Chd7 and Tbx1 in the pharyngeal ectoderm was required for normal PAA development...
  26. ncbi Fgf10 is an oncogene activated by MMTV insertional mutagenesis in mouse mammary tumors and overexpressed in a subset of human breast carcinomas
    Vassiliki Theodorou
    Division of Tumor Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Oncogene 23:6047-55. 2004
    ..in mammary tumors from BALB/c mice infected with C3H-MMTV, we have found a common MMTV insertion site in the Fgf10 locus...
  27. ncbi Isl1 identifies a cardiac progenitor population that proliferates prior to differentiation and contributes a majority of cells to the heart
    Chen Leng Cai
    Institute of Molecular Medicine, Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA
    Dev Cell 5:877-89. 2003
    ..Our results have implications for the development of specific cardiac lineages, left-right asymmetry, cardiac evolution, and isolation of cardiac progenitor cells...
  28. ncbi Lung hypoplasia and neonatal death in Fgf9-null mice identify this gene as an essential regulator of lung mesenchyme
    J S Colvin
    Department of Molecular Biology and Pharmacology, Washington University Medical School, Campus Box 8103, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Development 128:2095-106. 2001
    ..Fibroblast growth factors (FGFs) often mediate epithelial-mesenchymal interactions and mesenchymal Fgf10 is essential for epithelial branching in the developing lung...
  29. ncbi Colonic atresia without mesenteric vascular occlusion. The role of the fibroblast growth factor 10 signaling pathway
    Timothy J Fairbanks
    Department of Pediatric Surgery, Developmental Biology Program, Children s Hospital Los Angeles, Los Angeles, CA 90027, USA
    J Pediatr Surg 40:390-6. 2005
    ..Prenatal expression of fibroblast growth factor 10 (Fgf10), acting through fibroblast growth factor receptor 2b (Fgfr2b), is critical to the normal development of the colon...
  30. ncbi Heparanase cleavage of perlecan heparan sulfate modulates FGF10 activity during ex vivo submandibular gland branching morphogenesis
    Vaishali N Patel
    Matrix and Morphogenesis Unit, Laboratory of Cell and Developmental Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, Bethesda, MD, USA
    Development 134:4177-86. 2007
    ..activity in organ culture decreased branching morphogenesis, and this inhibition was rescued specifically by FGF10 and not by other FGFs...
  31. ncbi Cessation of Fgf10 signaling, resulting in a defective dental epithelial stem cell compartment, leads to the transition from crown to root formation
    Tamaki Yokohama-Tamaki
    Department of Oral Anatomy and Developmental Biology, Osaka University Graduate School of Dentistry, Osaka, Japan
    Development 133:1359-66. 2006
    ..continuous growth, owing to the formation and maintenance of a stem cell compartment by the constant expression of Fgf10. To clarify the relationship between root formation and disappearance of Fgf10, we carried out two experiments for ..
  32. ncbi Fibroblast growth factor 10 is required for survival and proliferation but not differentiation of intestinal epithelial progenitor cells during murine colon development
    Frederic G Sala
    UMR144 CNRS Institut Curie, 75248 Paris Cedex 05, France
    Dev Biol 299:373-85. 2006
    ..In this study, we determine the temporal-spatial expression pattern of Fibroblast growth factor 10 (Fgf10), a key developmental gene, in the colon at different developmental stages...
  33. ncbi Heparan sulfate-FGF10 interactions during lung morphogenesis
    Konstantin I Izvolsky
    Pulmonary Center, Department of Medicine, Boston University School of Medcine, MA 02118, USA
    Dev Biol 258:185-200. 2003
    Signaling by fibroblast growth factor 10 (FGF10) through FGFR2b is essential for lung development...
  34. ncbi The splanchnic mesodermal plate directs spleen and pancreatic laterality, and is regulated by Bapx1/Nkx3.2
    Jacob Hecksher-Sørensen
    Comparative and Developmental Genetics Section, MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK
    Development 131:4665-75. 2004
    ..In the absence of Fgf10 expression, the spleno-pancreatic mesenchyme and surrounding SMP grow laterally but contain no endodermal ..
  35. pmc FGF10/FGFR2b signaling is essential for cardiac fibroblast development and growth of the myocardium
    Mónica Vega-Hernández
    Department of Developmental Biology, Washington University School of Medicine, St Louis, MO 63110, USA
    Development 138:3331-40. 2011
    ..Here, we identify a myocardial to epicardial fibroblast growth factor (FGF) signal, mediated by FGF10 and FGFR2b, that is essential for movement of cardiac fibroblasts into the compact myocardium...
  36. pmc Signaling by FGFR2b controls the regenerative capacity of adult mouse incisors
    Sara Parsa
    Developmental Biology and Regenerative Medicine Program, Saban Research Institute of Children s Hospital Los Angeles, Los Angeles, CA 90027, USA
    Development 137:3743-52. 2010
    ..Previous studies have suggested that FGF10, acting mainly through fibroblast growth factor receptor 2b (FGFR2b), is crucial for development of the epithelial ..
  37. pmc Eyes absent 1 (Eya1) is a critical coordinator of epithelial, mesenchymal and vascular morphogenesis in the mammalian lung
    Ahmed H K El-Hashash
    Developmental Biology and Regenerative Medicine Program, Saban Research Institute, Childrens Hospital Los Angeles, Keck School of Medicine of University of Southern California, 4650 Sunset Boulevard MS35, Los Angeles, CA 90027, USA
    Dev Biol 350:112-26. 2011
    ..exhibit severe defects in the smooth muscle component of the bronchi and major pulmonary vessels with decreased Fgf10 expression. These defects lead to rupture of the major vessels and hemorrhage into the lungs after birth...
  38. ncbi Apoptosis, proliferation and gene expression patterns in mouse developing tongue
    Xuguang Nie
    Section of Anatomy and Cell Biology, Department of Biomedicine, University of Bergen, Jonas Lies V91, 5009, Bergen, Norway
    Anat Embryol (Berl) 210:125-32. 2005
    ..High expression of Fgf7 and Fgf10 was also detected in the mesenchyme at the early embryonic stage of tongue development, corresponding to the Fgfr ..
  39. ncbi Retinoic acid selectively regulates Fgf10 expression and maintains cell identity in the prospective lung field of the developing foregut
    Tushar J Desai
    Pulmonary Center, Boston University School of Medicine, Boston, MA 02118, USA
    Dev Biol 273:402-15. 2004
    ..a major role for RA is to selectively maintain mesodermal proliferation and induce fibroblast growth factor 10 (Fgf10) expression in the foregut region where the lung forms...
  40. doi Localization and fate of Fgf10-expressing cells in the adult mouse brain implicate Fgf10 in control of neurogenesis
    Mohammad K Hajihosseini
    School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, UK
    Mol Cell Neurosci 37:857-68. 2008
    We used Fgf10-lacZ reporter mice to investigate the distribution and fate of Fgf10-expressing cells in the developing and adult mouse brain...
  41. ncbi Loss of Tbx4 blocks hindlimb development and affects vascularization and fusion of the allantois
    L A Naiche
    Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, 701 W 168th Street, New York, NY 10032, USA
    Development 130:2681-93. 2003
    ..However, hindlimb buds from Tbx4 mutants fail to develop either in vivo or in vitro and do not maintain Fgf10 expression in the mesenchyme...
  42. ncbi FGF-10 disrupts lung morphogenesis and causes pulmonary adenomas in vivo
    J C Clark
    Division of Pulmonary Biology, Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
    Am J Physiol Lung Cell Mol Physiol 280:L705-15. 2001
    ..FGF-10 disrupted lung morphogenesis and induced multifocal pulmonary tumors in vivo and caused reversible type II cell differentiation of the respiratory epithelium...
  43. pmc Bmp4 is essential for the formation of the vestibular apparatus that detects angular head movements
    Weise Chang
    National Institute on Deafness and Other Communication Disorders, NIH, Rockville, Maryland, United States of America
    PLoS Genet 4:e1000050. 2008
    ..regulating genes required for prosensory development in the inner ear such as Serrate1 (Jagged1 in mouse), Fgf10, and Sox2...
  44. ncbi Requirements for FGF3 and FGF10 during inner ear formation
    Yolanda Alvarez
    Center for Molecular Neurobiology Hamburg, University of Hamburg, Falkenried 94, D 20251 Hamburg, Germany
    Development 130:6329-38. 2003
    ..Ectopic expression of FGF10 in the developing hindbrain of transgenic mice leads to the formation of ectopic vesicles, expressing some otic ..
  45. pmc Hes1 is required for pituitary growth and melanotrope specification
    Lori T Raetzman
    University of Michigan, Ann Arbor 48109 0618, USA
    Dev Biol 304:455-66. 2007
    ..These results demonstrate that Notch signaling plays multiple roles in pituitary development, influencing precursor number, organ size, cell differentiation and ultimately cell fate...
  46. ncbi Requirement for fibroblast growth factor 10 or fibroblast growth factor receptor 2-IIIb signaling for cecal development in mouse
    R C Burns
    Division of Developmental Biology, Department of Surgery, USC Keck School of Medicine and the Saban Research Institute of Childrens Hospital Los Angeles, Los Angeles, CA 90027, USA
    Dev Biol 265:61-74. 2004
    ..At E10.5, Fibroblast growth factor 10 (Fgf10) is specifically expressed in the mesenchyme above the future cecal epithelial bud, whereas Fgfr2b is found ..
  47. ncbi Wnt5a regulates Shh and Fgf10 signaling during lung development
    Changgong Li
    Department of Pediatrics, Women s and Children s Hospital, USC Keck School of Medicine, Los Angeles, CA 90033, USA
    Dev Biol 287:86-97. 2005
    ..During early lung development, over-expression of Wnt5a in the epithelium resulted in increased Fgf10 in the mesenchyme and decreased Shh in the epithelium...
  48. ncbi Cloning and expression pattern of a mouse homologue of drosophila sprouty in the mouse embryo
    A A de Maximy
    Institut Curie UMR 144 CNRS, 26 Rue d Ulm, 75248, Paris Cedex 05, France
    Mech Dev 81:213-6. 1999
    ..Sprouty4 expression is also detected in the lateral region of the somites. In the developing lung, Sprouty4 is expressed broadly in the distal mesenchyme...
  49. ncbi Fibroblast growth factor-10 serves a regulatory role in duodenal development
    Robert C Kanard
    Department of Pediatric Surgery, Developmental Biology Program, Childrens Hospital Los Angeles, 4650 Sunset Boulevard, Saban Research Building 524, Mail stop 100, Los Angeles, CA 90027, USA
    J Pediatr Surg 40:313-6. 2005
    ..Fibroblast growth factor-10 (Fgf10) is a known regulatory molecule relevant to mesenchymal-epithelial interactions, and mice deficient in Fgf10 ..
  50. ncbi FGF8 dose-dependent regulation of embryonic submandibular salivary gland morphogenesis
    Tina Jaskoll
    Laboratory for Developmental Genetics, University of Southern California, Los Angeles, CA 90089 0641, USA
    Dev Biol 268:457-69. 2004
    ..Furthermore, since FGF10 and Shh expression is modulated by Fgf8 levels, we postulated that exogenous FGF10, Shh, or FGF10 + Shh peptide ..
  51. ncbi Levels of mesenchymal FGFR2 signaling modulate smooth muscle progenitor cell commitment in the lung
    Stijn P De Langhe
    Developmental Biology Program, Department of Surgery, Saban Research Institute of Childrens Hospital Los Angeles, CA 90027, USA
    Dev Biol 299:52-62. 2006
    ..Using a set of in vivo and in vitro studies, we show that an autocrine FGF10-FGFR2b signaling loop is established in the mutant lung mesenchyme, which has several consequences...
  52. ncbi Differential role of FGF9 on epithelium and mesenchyme in mouse embryonic lung
    Pierre Marie del Moral
    Developmental Biology Program, Saban Research Institute of Children s Hospital Los Angeles, Los Angeles, CA 90027, USA
    Dev Biol 293:77-89. 2006
    ..At the molecular level, FGF9 up-regulates Fgf10 expression in the mesenchyme likely via increased expression of Tbx4 and 5 and controls the transcription of ..
  53. ncbi Stomach development is dependent on fibroblast growth factor 10/fibroblast growth factor receptor 2b-mediated signaling
    Bradley Spencer-Dene
    Experimental Pathology Laboratory, Cancer Research UK, London Research Institute, London, England
    Gastroenterology 130:1233-44. 2006
    ..unknown; however, the developmental expression profile of the IIIb isoform of Fgfr2 (Fgfr2b) and its main ligand, Fgf10, suggest that they may be strong candidates...
  54. ncbi Mouse fibroblast growth factor 10: cDNA cloning, protein characterization, and regulation of mRNA expression
    H D Beer
    Human Genome Sciences, Inc, Rockville, Maryland 20850, USA
    Oncogene 15:2211-8. 1997
    ..These results demonstrate a differential regulation of mFGF-10 and FGF-7 expression in vitro and during the wound healing process...
  55. ncbi Congenital heart defects in Fgfr2-IIIb and Fgf10 mutant mice
    Anita Marguerie
    Cancer Research UK, London Research Institute, 61 Lincoln s Inn Fields, London WC2A 3PX, UK
    Cardiovasc Res 71:50-60. 2006
    Myocardial progenitor cells expressing Fgf10 give rise to the outflow tract and right ventricle of the mammalian heart...
  56. ncbi Fgf9 signaling regulates inner ear morphogenesis through epithelial-mesenchymal interactions
    Ulla Pirvola
    Institute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland
    Dev Biol 273:350-60. 2004
    ..Together, these data show that Fgf9 signaling is required for inner ear morphogenesis...
  57. ncbi Dlx5 and Dlx6 homeobox genes are required for specification of the mammalian vestibular apparatus
    Raymond F Robledo
    The Jackson Laboratory, Bar Harbor, Maine
    Genesis 44:425-37. 2006
    ..Given their proximity to the disease locus and the observed phenotype in Dlx5/6 null mice, Dlx5/6 are likely candidates to mediate the inner ear defects observed in patients with split hand/split foot malformation...
  58. ncbi Gata3 is required for early morphogenesis and Fgf10 expression during otic development
    Kersti Lilleväli
    Institute of Biotechnology, University of Helsinki, Viikinkaari 9, 00710 Helsinki, Finland
    Mech Dev 123:415-29. 2006
    ..Inactivation of Gata3 leads also to a loss of Fgf10 expression in otic epithelium and auditory ganglion demonstrating that Gata3 is an important regulator of Fgf-..
  59. ncbi Tbx2 is essential for patterning the atrioventricular canal and for morphogenesis of the outflow tract during heart development
    Zachary Harrelson
    Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Development 131:5041-52. 2004
    ....
  60. pmc Sprouty genes control diastema tooth development via bidirectional antagonism of epithelial-mesenchymal FGF signaling
    Ophir D Klein
    Department of Anatomy and Program in Developmental Biology, School of Medicine, University of California, San Francisco, San Francisco, California 94143, USA
    Dev Cell 11:181-90. 2006
    ....
  61. ncbi VEGF-A signaling through Flk-1 is a critical facilitator of early embryonic lung epithelial to endothelial crosstalk and branching morphogenesis
    Pierre Marie del Moral
    Developmental Biology Program, Saban Research Institute, Children s Hospital Los Angeles, Department of Pediatric Surgery, USC Keck School of Medicine, 4650 Sunset Blvd, Los Angeles, CA 90027, USA
    Dev Biol 290:177-88. 2006
    ..These results demonstrate that the VEGF pathway is involved in driving epithelial to endothelial crosstalk in embryonic mouse lung morphogenesis...
  62. ncbi FGF-10 is a chemotactic factor for distal epithelial buds during lung development
    W Y Park
    Pulmonary Center, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Dev Biol 201:125-34. 1998
    ....
  63. ncbi Pitx1 and Pitx2 are required for development of hindlimb buds
    Alexandre Marcil
    Laboratoire de Genetique Moleculaire, Institut de Recherches Cliniques de Montreal, 110 avenue des Pins Ouest, Montreal, QC H2W 1R7, Canada
    Development 130:45-55. 2003
    ..Thus, Pitx1 and Pitx2 genes are required for sustained hindlimb bud growth and formation of hindlimbs...
  64. ncbi Gene expression profiles of mouse submandibular gland development: FGFR1 regulates branching morphogenesis in vitro through BMP- and FGF-dependent mechanisms
    Matthew P Hoffman
    Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, MSC 4370, Bethesda, MD 20892 4370, USA
    Development 129:5767-78. 2002
    ..FGFR1 signaling regulates Fgfr1, Fgf1, Fgf3 and Bmp7 expression and indirectly regulates Fgf7, Fgf10 and Bmp4. Exogenous FGFs and BMPs added to glands in culture reveal distinct effects on gland morphology...
  65. pmc An Fgf8 mouse mutant phenocopies human 22q11 deletion syndrome
    Deborah U Frank
    Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT 84112, USA
    Development 129:4591-603. 2002
    ..and heart due, at least in part, to failure to form the fourth pharyngeal arch arteries, altered expression of Fgf10 in the pharyngeal mesenchyme, and abnormal apoptosis in pharyngeal and cardiac neural crest...
  66. pmc Specification of the mammalian cochlea is dependent on Sonic hedgehog
    Martin M Riccomagno
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Genes Dev 16:2365-78. 2002
    ..Taken together, our data support a model whereby auditory cell fates in the otic vesicle are established by the direct action of Shh...
  67. ncbi FGF10 acts as a major ligand for FGF receptor 2 IIIb in mouse multi-organ development
    H Ohuchi
    Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, 46 29 Yoshida shimo adachi cho, Sakyo ku, Kyoto City, Kyoto, 606 8501, Japan
    Biochem Biophys Res Commun 277:643-9. 2000
    ..One of the candidate ligands is FGF10, because FGF10 binds to FGFR2b with high affinity and the formation of the limb and lung is arrested in FGF10 null ..
  68. ncbi Wnt5a participates in distal lung morphogenesis
    Changgong Li
    Department of Pediatrics, Women s and Children s Hospital, Los Angeles, CA 90033, USA
    Dev Biol 248:68-81. 2002
    ..Absence of WNT5a activity in the mutant lungs leads to increased expression of Fgf-10, Bmp4, Shh, and its receptor Ptc, raising the possibility that WNT5a, FGF-10, BMP4, and SHH signaling pathways are functionally interactive...
  69. ncbi Fibroblast growth factor receptor 2-IIIb acts upstream of Shh and Fgf4 and is required for limb bud maintenance but not for the induction of Fgf8, Fgf10, Msx1, or Bmp4
    J M Revest
    Imperial Cancer Research Fund, Lincoln s Inn Fields, London, WC2A 3PX, United Kingdom
    Dev Biol 231:47-62. 2001
    ..Its absence did not prevent expression of Fgf8, Fgf10, Bmp4, and Msx1, but did prevent induction of Shh and Fgf4, indicating that they are downstream targets of FgfR2-..
  70. ncbi Identification of BMP-4 as a signal mediating secondary induction between epithelial and mesenchymal tissues during early tooth development
    S Vainio
    Department of Pedodontics and Orthodontics, University of Helsinki, Finland
    Cell 75:45-58. 1993
    ..In addition, BMP-4 induced its own mesenchymal expression. These findings support the hypothesis that BMP-4 mediates epithelial-mesenchymal interactions during early tooth development...
  71. ncbi Evidence that SPROUTY2 functions as an inhibitor of mouse embryonic lung growth and morphogenesis
    A A Mailleux
    UMR144 CNRS Institut Curie, 26 Rue d Ulm, 75248 Cedex 05, Paris, France
    Mech Dev 102:81-94. 2001
    ..We and others have shown that Fibroblast Growth Factor 10 (FGF10) is a key positive regulator of lung branching morphogenesis...
  72. ncbi FGF10 maintains stem cell compartment in developing mouse incisors
    Hidemitsu Harada
    Second Department of Oral Anatomy and Cell Biology, Kyushu Dental College, 2 6 1, Manazuru, Kokurakita ku, Kitakyushu, 803 8580, Japan
    Development 129:1533-41. 2002
    ..To further illustrate the role of FGF10 in the formation of the stem cell compartment during tooth organogenesis, we have analyzed incisor development in ..
  73. ncbi Fgf10 is essential for maintaining the proliferative capacity of epithelial progenitor cells during early pancreatic organogenesis
    A Bhushan
    INSERM 457, Hospital Robert Debre, 75019 Paris, France
    Development 128:5109-17. 2001
    ..We demonstrate here that Fgf10, a member of the fibroblast growth factor family (FGFs), plays an essential role in this process...
  74. ncbi Endogenous and ectopic gland induction by FGF-10
    V Govindarajan
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, 77030, USA
    Dev Biol 225:188-200. 2000
    ..In addition, lacrimal and Harderian glands were not seen in FGF-10 null fetuses. Based on these results we propose that FGF-10 is an inductive signal that initiates ocular gland morphogenesis...
  75. ncbi Embryonic submandibular gland morphogenesis: stage-specific protein localization of FGFs, BMPs, Pax6 and Pax9 in normal mice and abnormal SMG phenotypes in FgfR2-IIIc(+/Delta), BMP7(-/-) and Pax6(-/-) mice
    Tina Jaskoll
    Laboratory for Developmental Genetics, University of Southern California, Los Angeles, CA 90089 0641, USA
    Cells Tissues Organs 170:83-98. 2002
    ..Finally, our observations of abnormal SMGs in BMP7(-/-) and Pax6(-/-) indicate that both BMP7 and Pax6 play important roles during embryonic SMG branching morphogenesis...
  76. ncbi FGF10 signaling maintains the pancreatic progenitor cell state revealing a novel role of Notch in organ development
    Gitte Anker Norgaard
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Dev Biol 264:323-38. 2003
    b>FGF10 plays an important role in the morphogenesis of several tissues by control of mesenchymal-to-epithelial signaling...
  77. pmc Multiple dose-dependent roles for Sox2 in the patterning and differentiation of anterior foregut endoderm
    Jianwen Que
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Development 134:2521-31. 2007
    ..These findings suggest that Sox2 plays a second role in establishing the boundary between the keratinized, squamous esophagus/forestomach and glandular hindstomach...
  78. pmc Hes1 is expressed in the second heart field and is required for outflow tract development
    Francesca Rochais
    Developmental Biology Institute of Marseilles Luminy, UMR 6216 CNRS Université de la Méditerranée, Campus de Luminy, Marseille, France
    PLoS ONE 4:e6267. 2009
    ..In order to provide further insight into second heart field development we characterized the insertion site of a transgene expressed in the second heart field and outflow tract as the result of an integration site position effect...
  79. ncbi Fgf10 maintains notch activation, stimulates proliferation, and blocks differentiation of pancreatic epithelial cells
    Alan Hart
    Umeå Center for Molecular Medicine, University of Umea, Umea, Sweden
    Dev Dyn 228:185-93. 2003
    ..The fibroblast growth factor receptor (FGFR) 2b high-affinity ligand FGF10 has been linked to pancreatic epithelial cell proliferation, and we have shown previously that Notch signalling ..
  80. ncbi TBX1 is required for inner ear morphogenesis
    Francesca Vitelli
    Department of Pediatrics Cardiology, Baylor College of Medicine, Houston, TX 77030, USA
    Hum Mol Genet 12:2041-8. 2003
    ..Our data suggest that Tbx1 deletion in del22q11 patients may cause not only external and middle ear defects but also sensorineural and vestibular phenotypes observed in these patients...
  81. ncbi beta-Catenin is required for specification of proximal/distal cell fate during lung morphogenesis
    Michael L Mucenski
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Biol Chem 278:40231-8. 2003
    ..These observations establish, for the first time, both the sites and timing of specification of the proximal and peripheral airways in the developing lung, and that beta-catenin is one of the essential components of this specification...
  82. pmc In vivo genetic ablation of the periotic mesoderm affects cell proliferation survival and differentiation in the cochlea
    Huansheng Xu
    Institute of Biosciences and Technology, Texas A and M Health Science Center, Houston, TX 77030, USA
    Dev Biol 310:329-40. 2007
    ..This model provides a striking demonstration of the essential role played by the periotic mesenchyme in the organogenesis of the cochlea...
  83. pmc Enhanced paracrine FGF10 expression promotes formation of multifocal prostate adenocarcinoma and an increase in epithelial androgen receptor
    Sanaz Memarzadeh
    Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Cancer Cell 12:572-85. 2007
    Enhanced mesenchymal expression of FGF10 led to the formation of multifocal PIN or prostate cancer. Inhibition of epithelial FGFR1 signaling using DN FGFR1 led to reversal of the cancer phenotype...
  84. ncbi Fibroblast growth factor interactions in the developing lung
    D Lebeche
    Pulmonary Center, Boston University School of Medicine, 80 East Concord Street R 304, Boston, MA 02118, USA
    Mech Dev 86:125-36. 1999
    ..Our data support a model in which Shh, TGFbeta-1 and BMP-4 counteract the bud promoting effects of FGF-10, and where FGF levels are maintained throughout lung development by other FGFs and Shh...
  85. ncbi FGF9 and SHH signaling coordinate lung growth and development through regulation of distinct mesenchymal domains
    Andrew C White
    Department of Molecular Biology and Pharmacology, Washington University Medical School, St Louis, MO 63110, USA
    Development 133:1507-17. 2006
    ....
  86. ncbi Mutations in the gene encoding fibroblast growth factor 10 are associated with aplasia of lacrimal and salivary glands
    Miriam Entesarian
    Department of Genetics and Pathology, Uppsala University, The Rudbeck Laboratory, SE 751 85 Uppsala, Sweden
    Nat Genet 37:125-7. 2005
    ..We mapped ALSG to 5p13.2-5q13.1, which coincides with the gene fibroblast growth factor 10 (FGF10). In two extended pedigrees, we identified heterozygous mutations in FGF10 in all individuals with ALSG...
  87. pmc The Cdk4-E2f1 pathway regulates early pancreas development by targeting Pdx1+ progenitors and Ngn3+ endocrine precursors
    So Yoon Kim
    Regenerative Biology Section, Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Development 138:1903-12. 2011
    ....
  88. pmc Noggin regulates Bmp4 activity during pituitary induction
    Shannon W Davis
    Department of Human Genetics, University of Michigan Medical School, 4909 Buhl Building, 1241 E Catherine St, Ann Arbor, MI 48109 0618, USA
    Dev Biol 305:145-60. 2007
    ..This work demonstrates the importance of attenuating the activity of Bmp signaling during pituitary induction in order to maintain the proper balance of signaling factors necessary for pituitary organogenesis...
  89. pmc 2,3,7,8-Tetrachlorodibenzo-p-dioxin inhibits fibroblast growth factor 10-induced prostatic bud formation in mouse urogenital sinus
    Chad M Vezina
    Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin 53705 2222, USA
    Toxicol Sci 113:198-206. 2010
    ..The purpose of this study was to determine whether inhibition of fibroblast growth factor 10 (FGF10) signaling is mechanistically linked to mouse prostatic budding impairment by TCDD...
  90. ncbi BMP signals control limb bud interdigital programmed cell death by regulating FGF signaling
    Sangeeta Pajni-Underwood
    Laboratory of Cancer and Developmental Biology National Institutes of Health, Frederick, MD 21702, USA
    Development 134:2359-68. 2007
    ..We conclude that during normal embryogenesis, BMP signaling to the AER indirectly regulates interdigit PCD by regulating AER-FGFs, which act as survival factors for the interdigit mesenchyme...
  91. pmc Tbx3 is required for outflow tract development
    Karim Mesbah
    Developmental Biology Institute of Marseilles Luminy, France
    Circ Res 103:743-50. 2008
    ....
  92. ncbi Defective terminal differentiation and hypoplasia of the epidermis in mice lacking the Fgf10 gene
    K Suzuki
    Center for Animal Resources and Development, Kumamoto University, Japan
    FEBS Lett 481:53-6. 2000
    Here, we characterized the skin and hair phenotype of mice lacking the fibroblast growth factor 10 gene (Fgf10), a newly identified member of the fibroblast growth factor family...
  93. ncbi The role of neural crest during cardiac development in a mouse model of DiGeorge syndrome
    Lazaros Kochilas
    Cardiovascular Division, University of Pennsylvania, Philadelphia 19104, USA
    Dev Biol 251:157-66. 2002
    ..Based on our studies, we propose that Lgdel genes are required for the expression of soluble signals that regulate neural crest cell differentiation...
  94. doi The migrating gubernaculum grows like a "limb bud"
    Sophie S Nightingale
    Department of General Surgery, Royal Children s Hospital, Melbourne 3052, Australia
    J Pediatr Surg 43:387-90. 2008
    ..Recent studies show active proliferation in the tip. We hypothesized that the gubernacular tip may grow like a limb bud...
  95. pmc Formation and differentiation of multiple mesenchymal lineages during lung development is regulated by beta-catenin signaling
    Stijn P De Langhe
    Developmental Biology Program, Department of Surgery, Saban Research Institute of Childrens Hospital Los Angeles, Los Angeles, California, USA
    PLoS ONE 3:e1516. 2008
    ..The role of ss-catenin signaling in mesodermal lineage formation and differentiation has been elusive...
  96. ncbi Expression and function of FGF10 in mammalian inner ear development
    Sarah Pauley
    Creighton University, Department of Biomedical Sciences, Omaha, Nebraska 68178, USA
    Dev Dyn 227:203-15. 2003
    We have investigated the expression of FGF10 during ear development and the effect of an FGF10 null mutation on ear development...
  97. ncbi Temporal effects of Sprouty on lung morphogenesis
    Anne Karina T Perl
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Dev Biol 258:154-68. 2003
    ..These findings demonstrate that the embryonic-pseudoglandular stage is a critical time period during which Spry-sensitive pathways are required for branching morphogenesis, lobulation, and formation of the peripheral lung parenchyma...
  98. doi Terminal end bud maintenance in mammary gland is dependent upon FGFR2b signaling
    Sara Parsa
    Developmental Biology Program, Saban Research Institute of Childrens Hospital Los Angeles, Los Angeles, CA 90027, USA
    Dev Biol 317:121-31. 2008
    We previously demonstrated that Fibroblast Growth Factor 10 (FGF10) and its receptor FGFR2b play a key role in controlling the very early stages of mammary gland development during embryogenesis [Mailleux, A.A., Spencer-Dene, B...
  99. ncbi Keratinocyte growth factor receptor ligands target the receptor to different intracellular pathways
    Francesca Belleudi
    Dipartimento di Medicina Sperimentale, Universita di Roma La Sapienza, Viale Regina Elena 324, 00161 Roma, Italy
    Traffic 8:1854-72. 2007
    ..interaction with two different ligands, keratinocyte growth factor (KGF)/fibroblast growth factor (FGF)7 and FGF10/KGF2, which are characterized by an opposite requirement of heparan sulfate proteoglycans and heparin for binding ..
  100. pmc Mouse R-spondin2 is required for apical ectodermal ridge maintenance in the hindlimb
    Ju Suk Nam
    Center for Molecular Medicine, Maine Medical Center Research Institute, 81 Research Drive, Scarborough, ME 04074, USA
    Dev Biol 311:124-35. 2007
    ..Our findings strongly suggest that Rspo2 expression in the AER is required for AER maintenance likely by regulating Wnt/beta-catenin signaling...
  101. ncbi Heparan sulfates expressed in the distal lung are required for Fgf10 binding to the epithelium and for airway branching
    Konstantin I Izvolsky
    Pulmonary Ctr, Boston Univ School of Medicine, 80 E Concord St R 304, Boston, MA 02118, USA
    Am J Physiol Lung Cell Mol Physiol 285:L838-46. 2003
    Fibroblast growth factor (Fgf) 10 is a critical regulator of bud formation during lung morphogenesis. fgf10 is expressed in distal lung mesenchyme at sites of prospective budding from the earliest developmental stages and signals through ..

Research Grants25

  1. Notch signaling regulates pituitary gland organogenesis
    Lori Raetzman; Fiscal Year: 2009
    ..They may also reveal genetic causes of congenital pituitary hormone deficiency and pituitary tumorigenesis and offer novel insight into the function of Notch signaling in endocrine cell differentiation. ..
  2. Fetal Lung Development:Role of Wnt5a Signaling
    Changgong Li; Fiscal Year: 2007
    ..This information will be of utility in understanding the molecular mechanisms of congenital and induced lung disease. ..
  3. Eda/Edar Regulation of Embryonic SMG Development
    Tina Jaskoll; Fiscal Year: 2007
    ....
  4. Role of microRNAs in mammalian ear development and neurosensory specification
    Garrett A Soukup; Fiscal Year: 2010
    ..Understanding how these small RNAs influence such processes is expected to impact molecular therapeutic strategies designed to regenerate sensory cells and restoring hearing. ..
  5. Role of homeobox proteins in muscle development
    Helen P Makarenkova; Fiscal Year: 2010
    ..Defining the roles of Barx2 in muscle development, function and repair should help to build a more complete understanding of the muscle regulatory network that may aid in diagnosing or treating muscle disease. ..
  6. Notch Sigaling in Morphogenesis of Mouse Prostate
    Irina Grishina; Fiscal Year: 2007
    ..In perspective, those results may aid towards novel therapies to overcome genetic or injury inflicted pathologies in branched glands. ..
  7. The function of Foxi3 in craniofacial development
    Takahiro Ohyama; Fiscal Year: 2007
    ..This project has significant potential for the future study of craniofacial and sensory organ development that will shed light on the genetic mechanisms of craniofacial birth defects. ..
  8. COBRE: CREIGHTON UNIVERISTY: P1:ROLE OF MICRORNAS IN DEVELOPMENT OF THE EAR
    Garrett A Soukup; Fiscal Year: 2009
    ..Specific Aim 3. To identify downstream effector genes through which EGFR regulates the development of the PNS. ..