Genomes and Genes
Gene Symbol: Fgf10
Description: fibroblast growth factor 10
Alias: AEY17, BB213776, Fgf-10, Gsfaey17, keratinocyte growth factor 2
Publications127 found, 100 shown here
- An FGF signaling loop sustains the generation of differentiated progeny from stem cells in mouse incisorsOphir D Klein
Department of Anatomy and Program in Developmental Biology, School of Medicine, University of California at San Francisco, San Francisco, CA 94143 2711, USA
Development 135:377-85. 2008..These data reveal that the generation of differentiated progeny from a particular stem cell population can be differently regulated in the embryo and adult...
- Isl1 identifies a cardiac progenitor population that proliferates prior to differentiation and contributes a majority of cells to the heartChen Leng Cai
Institute of Molecular Medicine, Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA
Dev Cell 5:877-89. 2003..Our results have implications for the development of specific cardiac lineages, left-right asymmetry, cardiac evolution, and isolation of cardiac progenitor cells...
- Fgf10 is an oncogene activated by MMTV insertional mutagenesis in mouse mammary tumors and overexpressed in a subset of human breast carcinomasVassiliki Theodorou
Division of Tumor Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
Oncogene 23:6047-55. 2004..in mammary tumors from BALB/c mice infected with C3H-MMTV, we have found a common MMTV insertion site in the Fgf10 locus...
- A splicing switch and gain-of-function mutation in FgfR2-IIIc hemizygotes causes Apert/Pfeiffer-syndrome-like phenotypesM K Hajihosseini
Imperial Cancer Research Fund, 44 Lincoln s Inn Fields, London WC2A 3PX, United Kingdom
Proc Natl Acad Sci U S A 98:3855-60. 2001..This phenotype has strong parallels to some Apert's and Pfeiffer's syndrome patients...
- Lung hypoplasia and neonatal death in Fgf9-null mice identify this gene as an essential regulator of lung mesenchymeJ S Colvin
Department of Molecular Biology and Pharmacology, Washington University Medical School, Campus Box 8103, 660 S Euclid Avenue, St Louis, MO 63110, USA
Development 128:2095-106. 2001..Fibroblast growth factors (FGFs) often mediate epithelial-mesenchymal interactions and mesenchymal Fgf10 is essential for epithelial branching in the developing lung...
- Cloning and expression pattern of a mouse homologue of drosophila sprouty in the mouse embryoA A de Maximy
Institut Curie UMR 144 CNRS, 26 Rue d Ulm, 75248, Paris Cedex 05, France
Mech Dev 81:213-6. 1999..Sprouty4 expression is also detected in the lateral region of the somites. In the developing lung, Sprouty4 is expressed broadly in the distal mesenchyme...
- The splanchnic mesodermal plate directs spleen and pancreatic laterality, and is regulated by Bapx1/Nkx3.2Jacob Hecksher-Sørensen
Comparative and Developmental Genetics Section, MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK
Development 131:4665-75. 2004..In the absence of Fgf10 expression, the spleno-pancreatic mesenchyme and surrounding SMP grow laterally but contain no endodermal ..
- Apoptosis, proliferation and gene expression patterns in mouse developing tongueXuguang Nie
Section of Anatomy and Cell Biology, Department of Biomedicine, University of Bergen, Jonas Lies V91, 5009, Bergen, Norway
Anat Embryol (Berl) 210:125-32. 2005..High expression of Fgf7 and Fgf10 was also detected in the mesenchyme at the early embryonic stage of tongue development, corresponding to the Fgfr ..
- Bmp4 is essential for the formation of the vestibular apparatus that detects angular head movementsWeise Chang
National Institute on Deafness and Other Communication Disorders, NIH, Rockville, Maryland, United States of America
PLoS Genet 4:e1000050. 2008..regulating genes required for prosensory development in the inner ear such as Serrate1 (Jagged1 in mouse), Fgf10, and Sox2...
- TBX1 is required for inner ear morphogenesisFrancesca Vitelli
Department of Pediatrics Cardiology, Baylor College of Medicine, Houston, TX 77030, USA
Hum Mol Genet 12:2041-8. 2003..Our data suggest that Tbx1 deletion in del22q11 patients may cause not only external and middle ear defects but also sensorineural and vestibular phenotypes observed in these patients...
- Fgf9 signaling regulates inner ear morphogenesis through epithelial-mesenchymal interactionsUlla Pirvola
Institute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland
Dev Biol 273:350-60. 2004..Together, these data show that Fgf9 signaling is required for inner ear morphogenesis...
- Specification of the mammalian cochlea is dependent on Sonic hedgehogMartin M Riccomagno
Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Genes Dev 16:2365-78. 2002..Taken together, our data support a model whereby auditory cell fates in the otic vesicle are established by the direct action of Shh...
- Tbx1 has a dual role in the morphogenesis of the cardiac outflow tractHuansheng Xu
Program in Cardiovascular Sciences, Baylor College of Medicine, Houston, TX 77030, USA
Development 131:3217-27. 2004..This process might be regulated in part by Fgf10, which we show for the first time to be a direct target of Tbx1 in vitro...
- Gene expression profiles of mouse submandibular gland development: FGFR1 regulates branching morphogenesis in vitro through BMP- and FGF-dependent mechanismsMatthew P Hoffman
Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, MSC 4370, Bethesda, MD 20892 4370, USA
Development 129:5767-78. 2002..FGFR1 signaling regulates Fgfr1, Fgf1, Fgf3 and Bmp7 expression and indirectly regulates Fgf7, Fgf10 and Bmp4. Exogenous FGFs and BMPs added to glands in culture reveal distinct effects on gland morphology...
- FGF8 dose-dependent regulation of embryonic submandibular salivary gland morphogenesisTina Jaskoll
Laboratory for Developmental Genetics, University of Southern California, Los Angeles, CA 90089 0641, USA
Dev Biol 268:457-69. 2004..Furthermore, since FGF10 and Shh expression is modulated by Fgf8 levels, we postulated that exogenous FGF10, Shh, or FGF10 + Shh peptide ..
- Pitx1 and Pitx2 are required for development of hindlimb budsAlexandre Marcil
Laboratoire de Genetique Moleculaire, Institut de Recherches Cliniques de Montreal, 110 avenue des Pins Ouest, Montreal, QC H2W 1R7, Canada
Development 130:45-55. 2003..Thus, Pitx1 and Pitx2 genes are required for sustained hindlimb bud growth and formation of hindlimbs...
- beta-Catenin is required for specification of proximal/distal cell fate during lung morphogenesisMichael L Mucenski
Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
J Biol Chem 278:40231-8. 2003..These observations establish, for the first time, both the sites and timing of specification of the proximal and peripheral airways in the developing lung, and that beta-catenin is one of the essential components of this specification...
- FGF10 signaling maintains the pancreatic progenitor cell state revealing a novel role of Notch in organ developmentGitte Anker Norgaard
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Dev Biol 264:323-38. 2003b>FGF10 plays an important role in the morphogenesis of several tissues by control of mesenchymal-to-epithelial signaling...
- Fgf10 maintains notch activation, stimulates proliferation, and blocks differentiation of pancreatic epithelial cellsAlan Hart
Umeå Center for Molecular Medicine, University of Umea, Umea, Sweden
Dev Dyn 228:185-93. 2003..The fibroblast growth factor receptor (FGFR) 2b high-affinity ligand FGF10 has been linked to pancreatic epithelial cell proliferation, and we have shown previously that Notch signalling ..
- Great vessel development requires biallelic expression of Chd7 and Tbx1 in pharyngeal ectoderm in miceVictoria Randall
Molecular Medicine Unit, Institute of Child Health, London, United Kingdom
J Clin Invest 119:3301-10. 2009..We could not rescue PAA morphogenesis by restoring neural crest Chd7 expression. Rather, biallelic expression of Chd7 and Tbx1 in the pharyngeal ectoderm was required for normal PAA development...
- Tbx2 is essential for patterning the atrioventricular canal and for morphogenesis of the outflow tract during heart developmentZachary Harrelson
Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
Development 131:5041-52. 2004....
- Hes1 is expressed in the second heart field and is required for outflow tract developmentFrancesca Rochais
Developmental Biology Institute of Marseilles Luminy, UMR 6216 CNRS Université de la Méditerranée, Campus de Luminy, Marseille, France
PLoS ONE 4:e6267. 2009..In order to provide further insight into second heart field development we characterized the insertion site of a transgene expressed in the second heart field and outflow tract as the result of an integration site position effect...
- Enhanced paracrine FGF10 expression promotes formation of multifocal prostate adenocarcinoma and an increase in epithelial androgen receptorSanaz Memarzadeh
Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
Cancer Cell 12:572-85. 2007Enhanced mesenchymal expression of FGF10 led to the formation of multifocal PIN or prostate cancer. Inhibition of epithelial FGFR1 signaling using DN FGFR1 led to reversal of the cancer phenotype...
- In vivo genetic ablation of the periotic mesoderm affects cell proliferation survival and differentiation in the cochleaHuansheng Xu
Institute of Biosciences and Technology, Texas A and M Health Science Center, Houston, TX 77030, USA
Dev Biol 310:329-40. 2007..This model provides a striking demonstration of the essential role played by the periotic mesenchyme in the organogenesis of the cochlea...
- Fgf10 dosage is critical for the amplification of epithelial cell progenitors and for the formation of multiple mesenchymal lineages during lung developmentSuresh K Ramasamy
Developmental Biology Program, Saban Research Institute of Childrens Hospital Los Angeles, Los Angeles, CA 90027, USA
Dev Biol 307:237-47. 2007The key role played by Fgf10 during early lung development is clearly illustrated in Fgf10 knockout mice, which exhibit lung agenesis...
- Multiple dose-dependent roles for Sox2 in the patterning and differentiation of anterior foregut endodermJianwen Que
Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
Development 134:2521-31. 2007..These findings suggest that Sox2 plays a second role in establishing the boundary between the keratinized, squamous esophagus/forestomach and glandular hindstomach...
- Levels of mesenchymal FGFR2 signaling modulate smooth muscle progenitor cell commitment in the lungStijn P De Langhe
Developmental Biology Program, Department of Surgery, Saban Research Institute of Childrens Hospital Los Angeles, CA 90027, USA
Dev Biol 299:52-62. 2006..Using a set of in vivo and in vitro studies, we show that an autocrine FGF10-FGFR2b signaling loop is established in the mutant lung mesenchyme, which has several consequences...
- Dlx5 and Dlx6 homeobox genes are required for specification of the mammalian vestibular apparatusRaymond F Robledo
The Jackson Laboratory, Bar Harbor, Maine
Genesis 44:425-37. 2006..Given their proximity to the disease locus and the observed phenotype in Dlx5/6 null mice, Dlx5/6 are likely candidates to mediate the inner ear defects observed in patients with split hand/split foot malformation...
- Sprouty genes control diastema tooth development via bidirectional antagonism of epithelial-mesenchymal FGF signalingOphir D Klein
Department of Anatomy and Program in Developmental Biology, School of Medicine, University of California, San Francisco, San Francisco, California 94143, USA
Dev Cell 11:181-90. 2006....
- Gata3 is required for early morphogenesis and Fgf10 expression during otic developmentKersti Lilleväli
Institute of Biotechnology, University of Helsinki, Viikinkaari 9, 00710 Helsinki, Finland
Mech Dev 123:415-29. 2006..Inactivation of Gata3 leads also to a loss of Fgf10 expression in otic epithelium and auditory ganglion demonstrating that Gata3 is an important regulator of Fgf-..
- Congenital heart defects in Fgfr2-IIIb and Fgf10 mutant miceAnita Marguerie
Cancer Research UK, London Research Institute, 61 Lincoln s Inn Fields, London WC2A 3PX, UK
Cardiovasc Res 71:50-60. 2006Myocardial progenitor cells expressing Fgf10 give rise to the outflow tract and right ventricle of the mammalian heart...
- Stomach development is dependent on fibroblast growth factor 10/fibroblast growth factor receptor 2b-mediated signalingBradley Spencer-Dene
Experimental Pathology Laboratory, Cancer Research UK, London Research Institute, London, England
Gastroenterology 130:1233-44. 2006..unknown; however, the developmental expression profile of the IIIb isoform of Fgfr2 (Fgfr2b) and its main ligand, Fgf10, suggest that they may be strong candidates...
- Differential role of FGF9 on epithelium and mesenchyme in mouse embryonic lungPierre Marie del Moral
Developmental Biology Program, Saban Research Institute of Children s Hospital Los Angeles, Los Angeles, CA 90027, USA
Dev Biol 293:77-89. 2006..At the molecular level, FGF9 up-regulates Fgf10 expression in the mesenchyme likely via increased expression of Tbx4 and 5 and controls the transcription of ..
- VEGF-A signaling through Flk-1 is a critical facilitator of early embryonic lung epithelial to endothelial crosstalk and branching morphogenesisPierre Marie del Moral
Developmental Biology Program, Saban Research Institute, Children s Hospital Los Angeles, Department of Pediatric Surgery, USC Keck School of Medicine, 4650 Sunset Blvd, Los Angeles, CA 90027, USA
Dev Biol 290:177-88. 2006..These results demonstrate that the VEGF pathway is involved in driving epithelial to endothelial crosstalk in embryonic mouse lung morphogenesis...
- Fgf10 expression identifies parabronchial smooth muscle cell progenitors and is required for their entry into the smooth muscle cell lineageArnaud A Mailleux
UMR144 CNRS Institut Curie, 75248 Paris Cedex 05, France
Development 132:2157-66. 2005..Using a transgenic mouse line expressing LacZ under the control of Fgf10 regulatory sequences, we show that the pool of Fgf10-positive cells in the distal lung mesenchyme contains ..
- An Fgf8 mouse mutant phenocopies human 22q11 deletion syndromeDeborah U Frank
Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT 84112, USA
Development 129:4591-603. 2002..and heart due, at least in part, to failure to form the fourth pharyngeal arch arteries, altered expression of Fgf10 in the pharyngeal mesenchyme, and abnormal apoptosis in pharyngeal and cardiac neural crest...
- FGF10 maintains stem cell compartment in developing mouse incisorsHidemitsu Harada
Second Department of Oral Anatomy and Cell Biology, Kyushu Dental College, 2 6 1, Manazuru, Kokurakita ku, Kitakyushu, 803 8580, Japan
Development 129:1533-41. 2002..To further illustrate the role of FGF10 in the formation of the stem cell compartment during tooth organogenesis, we have analyzed incisor development in ..
- Fibroblast growth factor receptor 2-IIIb acts upstream of Shh and Fgf4 and is required for limb bud maintenance but not for the induction of Fgf8, Fgf10, Msx1, or Bmp4J M Revest
Imperial Cancer Research Fund, Lincoln s Inn Fields, London, WC2A 3PX, United Kingdom
Dev Biol 231:47-62. 2001..Its absence did not prevent expression of Fgf8, Fgf10, Bmp4, and Msx1, but did prevent induction of Shh and Fgf4, indicating that they are downstream targets of FgfR2-..
- FGF10 acts as a major ligand for FGF receptor 2 IIIb in mouse multi-organ developmentH Ohuchi
Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, 46 29 Yoshida shimo adachi cho, Sakyo ku, Kyoto City, Kyoto, 606 8501, Japan
Biochem Biophys Res Commun 277:643-9. 2000..One of the candidate ligands is FGF10, because FGF10 binds to FGFR2b with high affinity and the formation of the limb and lung is arrested in FGF10 null ..
- Fibroblast growth factor 10 (FGF10) and branching morphogenesis in the embryonic mouse lungS Bellusci
Department of Cell Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2175, USA
Development 124:4867-78. 1997..We report here that fibroblast growth factor 10 (Fgf10) is expressed dynamically in the mesenchyme adjacent to the distal buds from the earliest stages of lung ..
- Fgf10 is essential for maintaining the proliferative capacity of epithelial progenitor cells during early pancreatic organogenesisA Bhushan
INSERM 457, Hospital Robert Debre, 75019 Paris, France
Development 128:5109-17. 2001..We demonstrate here that Fgf10, a member of the fibroblast growth factor family (FGFs), plays an essential role in this process...
- Endogenous and ectopic gland induction by FGF-10V Govindarajan
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, 77030, USA
Dev Biol 225:188-200. 2000..In addition, lacrimal and Harderian glands were not seen in FGF-10 null fetuses. Based on these results we propose that FGF-10 is an inductive signal that initiates ocular gland morphogenesis...
- Mouse fibroblast growth factor 10: cDNA cloning, protein characterization, and regulation of mRNA expressionH D Beer
Human Genome Sciences, Inc, Rockville, Maryland 20850, USA
Oncogene 15:2211-8. 1997..These results demonstrate a differential regulation of mFGF-10 and FGF-7 expression in vitro and during the wound healing process...
- Fibroblast growth factor interactions in the developing lungD Lebeche
Pulmonary Center, Boston University School of Medicine, 80 East Concord Street R 304, Boston, MA 02118, USA
Mech Dev 86:125-36. 1999..Our data support a model in which Shh, TGFbeta-1 and BMP-4 counteract the bud promoting effects of FGF-10, and where FGF levels are maintained throughout lung development by other FGFs and Shh...
- FGF-10 is a chemotactic factor for distal epithelial buds during lung developmentW Y Park
Pulmonary Center, Boston University School of Medicine, Boston, Massachusetts 02118, USA
Dev Biol 201:125-34. 1998....
- Identification of BMP-4 as a signal mediating secondary induction between epithelial and mesenchymal tissues during early tooth developmentS Vainio
Department of Pedodontics and Orthodontics, University of Helsinki, Finland
Cell 75:45-58. 1993..In addition, BMP-4 induced its own mesenchymal expression. These findings support the hypothesis that BMP-4 mediates epithelial-mesenchymal interactions during early tooth development...
- Embryonic submandibular gland morphogenesis: stage-specific protein localization of FGFs, BMPs, Pax6 and Pax9 in normal mice and abnormal SMG phenotypes in FgfR2-IIIc(+/Delta), BMP7(-/-) and Pax6(-/-) miceTina Jaskoll
Laboratory for Developmental Genetics, University of Southern California, Los Angeles, CA 90089 0641, USA
Cells Tissues Organs 170:83-98. 2002..Finally, our observations of abnormal SMGs in BMP7(-/-) and Pax6(-/-) indicate that both BMP7 and Pax6 play important roles during embryonic SMG branching morphogenesis...
- Evidence that SPROUTY2 functions as an inhibitor of mouse embryonic lung growth and morphogenesisA A Mailleux
UMR144 CNRS Institut Curie, 26 Rue d Ulm, 75248 Cedex 05, Paris, France
Mech Dev 102:81-94. 2001..We and others have shown that Fibroblast Growth Factor 10 (FGF10) is a key positive regulator of lung branching morphogenesis...
- Wnt5a participates in distal lung morphogenesisChanggong Li
Department of Pediatrics, Women s and Children s Hospital, Los Angeles, CA 90033, USA
Dev Biol 248:68-81. 2002..Absence of WNT5a activity in the mutant lungs leads to increased expression of Fgf-10, Bmp4, Shh, and its receptor Ptc, raising the possibility that WNT5a, FGF-10, BMP4, and SHH signaling pathways are functionally interactive...
- Role of FGF10/FGFR2b signaling during mammary gland development in the mouse embryoArnaud André Mailleux
UMR144 CNRS Institut Curie, 26 rue d Ulm 75248 Paris Cedex 05, France
Development 129:53-60. 2002..placode development using Lef1 as a marker for the epithelial component of the placode, and mice deficient for Fgf10 or Fgfr2b, both of which fail to develop normal mammary glands...
- FGF-10 disrupts lung morphogenesis and causes pulmonary adenomas in vivoJ C Clark
Division of Pulmonary Biology, Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
Am J Physiol Lung Cell Mol Physiol 280:L705-15. 2001..FGF-10 disrupted lung morphogenesis and induced multifocal pulmonary tumors in vivo and caused reversible type II cell differentiation of the respiratory epithelium...
- Fgf-10 is required for both limb and lung development and exhibits striking functional similarity to Drosophila branchlessH Min
Department of Molecular Genetics, Amgen, Inc, Thousand Oaks, California 91320 1789 USA
Genes Dev 12:3156-61. 1998..The pulmonary phenotype of Fgf-10(-/-) mice is strikingly similar to that of the Drosophila mutant branchless, an Fgf homolog...
- Hes1 is required for pituitary growth and melanotrope specificationLori T Raetzman
University of Michigan, Ann Arbor 48109 0618, USA
Dev Biol 304:455-66. 2007..These results demonstrate that Notch signaling plays multiple roles in pituitary development, influencing precursor number, organ size, cell differentiation and ultimately cell fate...
- Mutations in the gene encoding fibroblast growth factor 10 are associated with aplasia of lacrimal and salivary glandsMiriam Entesarian
Department of Genetics and Pathology, Uppsala University, The Rudbeck Laboratory, SE 751 85 Uppsala, Sweden
Nat Genet 37:125-7. 2005..We mapped ALSG to 5p13.2-5q13.1, which coincides with the gene fibroblast growth factor 10 (FGF10). In two extended pedigrees, we identified heterozygous mutations in FGF10 in all individuals with ALSG...
- Wnt5a regulates Shh and Fgf10 signaling during lung developmentChanggong Li
Department of Pediatrics, Women s and Children s Hospital, USC Keck School of Medicine, Los Angeles, CA 90033, USA
Dev Biol 287:86-97. 2005..During early lung development, over-expression of Wnt5a in the epithelium resulted in increased Fgf10 in the mesenchyme and decreased Shh in the epithelium...
- FGF9 and SHH signaling coordinate lung growth and development through regulation of distinct mesenchymal domainsAndrew C White
Department of Molecular Biology and Pharmacology, Washington University Medical School, St Louis, MO 63110, USA
Development 133:1507-17. 2006....
- Fgf10 is essential for limb and lung formationK Sekine
Institute of Molecular and Cellular Biosciences, The University of Tokyo, Japan
Nat Genet 21:138-41. 1999..In particular, Fgf10 is predicted to function as a regulator of brain, lung and limb development on the basis of its spatiotemporal ..
- The arterial pole of the mouse heart forms from Fgf10-expressing cells in pharyngeal mesodermR G Kelly
Departement de Biologie Moleculaire, Institut Pasteur, Paris, France
Dev Cell 1:435-40. 2001..The nlacZ transgene has integrated upstream of the fibroblast growth factor 10 (Fgf10) gene and comparison with the expression pattern of Fgf10 in pharyngeal mesoderm indicates transgene control by ..
- Noggin regulates Bmp4 activity during pituitary inductionShannon W Davis
Department of Human Genetics, University of Michigan Medical School, 4909 Buhl Building, 1241 E Catherine St, Ann Arbor, MI 48109 0618, USA
Dev Biol 305:145-60. 2007..This work demonstrates the importance of attenuating the activity of Bmp signaling during pituitary induction in order to maintain the proper balance of signaling factors necessary for pituitary organogenesis...
- BMP signals control limb bud interdigital programmed cell death by regulating FGF signalingSangeeta Pajni-Underwood
Laboratory of Cancer and Developmental Biology National Institutes of Health, Frederick, MD 21702, USA
Development 134:2359-68. 2007..We conclude that during normal embryogenesis, BMP signaling to the AER indirectly regulates interdigit PCD by regulating AER-FGFs, which act as survival factors for the interdigit mesenchyme...
- 2,3,7,8-Tetrachlorodibenzo-p-dioxin inhibits fibroblast growth factor 10-induced prostatic bud formation in mouse urogenital sinusChad M Vezina
Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin 53705 2222, USA
Toxicol Sci 113:198-206. 2010..The purpose of this study was to determine whether inhibition of fibroblast growth factor 10 (FGF10) signaling is mechanistically linked to mouse prostatic budding impairment by TCDD...
- The Cdk4-E2f1 pathway regulates early pancreas development by targeting Pdx1+ progenitors and Ngn3+ endocrine precursorsSo Yoon Kim
Regenerative Biology Section, Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Development 138:1903-12. 2011....
- Sonic hedgehog signaling regulates reciprocal epithelial-mesenchymal interactions controlling palatal outgrowthYu Lan
Center for Oral Biology and Department of Biomedical Genetics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
Development 136:1387-96. 2009..Furthermore, we show that Shh signaling regulates Bmp2, Bmp4 and Fgf10 expression in the developing palatal mesenchyme and that specific inactivation of Smo in the palatal mesenchyme ..
- Regulation of FGF10 by POU transcription factor Brn3a in the developing trigeminal ganglionEric Cox
Department of Psychiatry, University of California, San Diego and VA San Diego Healthcare System, La Jolla, California 92093, USA
J Neurobiol 66:1075-83. 2006..Here we show that expression of the developmental regulator FGF10 is approximately 35-fold increased in the developing trigeminal ganglia of Brn3a-null mice...
- Essential mesenchymal role of small GTPase Rac1 in interdigital programmed cell death during limb developmentDai Suzuki
Department of Biochemistry, Showa University, Hatanodai, Shinagawa, Tokyo, Japan
Dev Biol 335:396-406. 2009..Our findings from Rac1 conditional mutants indicate crucial roles for Rac1 in limb bud morphogenesis, especially interdigital programmed cell death...
- Cusp patterning defect in Tabby mouse teeth and its partial rescue by FGFJ Pispa
Institute of Biotechnology, Viikki Biocenter, University of Helsinki, Finland
Dev Biol 216:521-34. 1999..Instead FGF-10 partially restored morphogenesis and stimulated the development of additional tooth cusps in cultured Tabby molars...
- Stabilization of beta-catenin impacts pancreas growthPatrick W Heiser
Diabetes Center, Department of Medicine, University of California, San Francisco, CA 94143, USA
Development 133:2023-32. 2006..Robust stabilization of beta-catenin during early organogenesis drives changes in hedgehog and Fgf10 signaling and induces a loss of Pdx1 expression in early pancreatic progenitor cells...
- Distinct roles for retinoic acid receptors alpha and beta in early lung morphogenesisTushar J Desai
Pulmonary Center, Boston University School of Medicine, 80 East Concord Street R 304, Boston, MA 02118, USA
Dev Biol 291:12-24. 2006..We show that activation of RAR beta, but not alpha, induces expression of the fibroblast growth factor Fgf10 and bud morphogenesis in the lung field...
- TGF-beta mediated FGF10 signaling in cranial neural crest cells controls development of myogenic progenitor cells through tissue-tissue interactions during tongue morphogenesisRyoichi Hosokawa
Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles, CA 90033, USA
Dev Biol 341:186-95. 2010..Loss of Tgfbr2 in CNC cells (Wnt1-Cre;Tgfbr2(flox/flox)) results in microglossia with reduced Scleraxis and Fgf10 expression as well as decreased myogenic cell proliferation, reduced cell number and disorganized tongue muscles...
- Characterization and in vivo pharmacological rescue of a Wnt2-Gata6 pathway required for cardiac inflow tract developmentYing Tian
Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
Dev Cell 18:275-87. 2010..These data reveal a molecular pathway regulating the posterior cardiac mesoderm and demonstrate that cardiovascular defects caused by loss of Wnt signaling can be rescued pharmacologically in vivo...
- FGF signaling regulates otic placode induction and refinement by controlling both ectodermal target genes and hindbrain Wnt8aLisa D Urness
Department of Human Genetics, University of Utah, 15 N 2030 E, RM 2100, Salt Lake City, UT 84112 5330, USA
Dev Biol 340:595-604. 2010..Mouse embryos lacking both Fgf3 and Fgf10 fail to initiate inner ear development because appropriate patterns of gene expression fail to be specified within ..
- Mouse R-spondin2 is required for apical ectodermal ridge maintenance in the hindlimbJu Suk Nam
Center for Molecular Medicine, Maine Medical Center Research Institute, 81 Research Drive, Scarborough, ME 04074, USA
Dev Biol 311:124-35. 2007..Our findings strongly suggest that Rspo2 expression in the AER is required for AER maintenance likely by regulating Wnt/beta-catenin signaling...
- Keratinocyte growth factor receptor ligands target the receptor to different intracellular pathwaysFrancesca Belleudi
Dipartimento di Medicina Sperimentale, Universita di Roma La Sapienza, Viale Regina Elena 324, 00161 Roma, Italy
Traffic 8:1854-72. 2007..interaction with two different ligands, keratinocyte growth factor (KGF)/fibroblast growth factor (FGF)7 and FGF10/KGF2, which are characterized by an opposite requirement of heparan sulfate proteoglycans and heparin for binding ..
- Defect in the maintenance of the apical ectodermal ridge in the Dactylaplasia mouseM A Crackower
Department of Molecular and Medical Genetics, University of Toronto, Toronto, Canada
Dev Biol 201:78-89. 1998..Moreover, the data suggest that the role of the AER maintenance factor is to promote cell proliferation in the ridge. Based on our findings, we propose a model for AER maintenance in the vertebrate limb...
- The loss of ventral ectoderm identity correlates with the inability to form an AER in the legless hindlimb budS M Bell
Division of Developmental Biology Children s Hospital Research Foundation, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
Mech Dev 74:41-50. 1998..These data suggest that establishment of a dorso-ventral ectodermal interface is not sufficient for AER formation and that restriction of lmx-1b to the dorsal mesenchyme is coordinately linked to AER formation...
- Mesenchymal cells are required for functional development of thymic epithelial cellsManami Itoi
Department of Immunology and Microbiology, Meiji University of Oriental Medicine, Hiyoshi cho, Nantan, Kyoto 629 0392, Japan
Int Immunol 19:953-64. 2007..In addition, our data suggest that mesenchymal cells are required to create the thymic microenvironment and to maintain epithelial architecture and function...
- Formation and differentiation of multiple mesenchymal lineages during lung development is regulated by beta-catenin signalingStijn P De Langhe
Developmental Biology Program, Department of Surgery, Saban Research Institute of Childrens Hospital Los Angeles, Los Angeles, California, USA
PLoS ONE 3:e1516. 2008..The role of ss-catenin signaling in mesodermal lineage formation and differentiation has been elusive...
- The migrating gubernaculum grows like a "limb bud"Sophie S Nightingale
Department of General Surgery, Royal Children s Hospital, Melbourne 3052, Australia
J Pediatr Surg 43:387-90. 2008..Recent studies show active proliferation in the tip. We hypothesized that the gubernacular tip may grow like a limb bud...
- Sprouty-2 regulates oncogenic K-ras in lung development and tumorigenesisAlice T Shaw
Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, and Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston 02114, USA
Genes Dev 21:694-707. 2007..These findings indicate that in the lung, Sprouty-2 plays a critical role in the regulation of oncogenic K-ras, and implicate counter-regulatory mechanisms in the pathogenesis of Ras-based disease...
- Terminal end bud maintenance in mammary gland is dependent upon FGFR2b signalingSara Parsa
Developmental Biology Program, Saban Research Institute of Childrens Hospital Los Angeles, Los Angeles, CA 90027, USA
Dev Biol 317:121-31. 2008We previously demonstrated that Fibroblast Growth Factor 10 (FGF10) and its receptor FGFR2b play a key role in controlling the very early stages of mammary gland development during embryogenesis [Mailleux, A.A., Spencer-Dene, B...
- Tbx3 is required for outflow tract developmentKarim Mesbah
Developmental Biology Institute of Marseilles Luminy, France
Circ Res 103:743-50. 2008....
- FGF alters epithelial competence for EGF at the initiation of branching morphogenesis of mouse submandibular glandMari Nitta
Department of Biology, Graduate School of Science, Chiba University, Chiba, Japan
Dev Dyn 238:315-23. 2009..branching occurred under the same culture conditions; however, both E12 and E13 epithelia elongated in response to FGF10. Reverse transcriptase-polymerase chain reaction studies showed that the expression of ErbB1 among four EGF ..
- Cooperative and antagonistic interactions between Sall4 and Tbx5 pattern the mouse limb and heartKazuko Koshiba-Takeuchi
Programs in Cardiovascular Research, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
Nat Genet 38:175-83. 2006..Thus, a positive and negative feed-forward circuit between Tbx5 and Sall4 ensures precise patterning of embryonic limb and heart and provides a unifying mechanism for heart/hand syndromes...
- Molecular analysis of external genitalia formation: the role of fibroblast growth factor (Fgf) genes during genital tubercle formationR Haraguchi
Center for Animal Resources and Development CARD, Kumamoto University, Honjo 2 2 1, Kumamoto 860 0811, Japan
Development 127:2471-9. 2000..in the distal urethral plate epithelium of the genital tubercle (GT) together with other markers such as the Msx1, Fgf10, Hoxd13 and Bmp4 expressed in the mesenchyme...
- Temporal effects of Sprouty on lung morphogenesisAnne Karina T Perl
Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
Dev Biol 258:154-68. 2003..These findings demonstrate that the embryonic-pseudoglandular stage is a critical time period during which Spry-sensitive pathways are required for branching morphogenesis, lobulation, and formation of the peripheral lung parenchyma...
- The del22q11.2 candidate gene Tbx1 regulates branchiomeric myogenesisRobert G Kelly
Department of Genetics and Development, Columbia University, New York, NY 10032, USA
Hum Mol Genet 13:2829-40. 2004..Tbx1 is also required for normal expression of Tlx1 and Fgf10 in pharyngeal mesoderm, in addition to correct neural crest cell patterning in the mandibular arch...
- Associations of FGF-3 and FGF-10 with signaling networks regulating tooth morphogenesisP Kettunen
Developmental Biology Programme, Institute of Biotechnology, Viikki Biocenter, University of Helsinki, Finland
Dev Dyn 219:322-32. 2000..The dynamic expression patterns of different Fgfs in dental epithelium and mesenchyme and their interactions suggest existence of regulatory signaling cascades between epithelial and mesenchymal FGFs during tooth development...
- The roles of Fgf4 and Fgf8 in limb bud initiation and outgrowthAnne M Boulet
Department of Human Genetics, Howard Hughes Medical Institute, University of Utah School of Medicine, Salt Lake City, UT 84112, USA
Dev Biol 273:361-72. 2004..mesoderm (IM) has been proposed to play a critical role in the initiation of limb bud outgrowth via restriction of Fgf10 expression to the appropriate region of the lateral plate mesoderm...
- FGF22 and its close relatives are presynaptic organizing molecules in the mammalian brainHisashi Umemori
Department of Anatomy and Neurobiology, Washington University Medical School, St Louis, MO 63110, USA
Cell 118:257-70. 2004..FGF7 and FGF10, the closest relatives of FGF22, share this activity; other FGFs have distinct effects...
- Heparan sulfates expressed in the distal lung are required for Fgf10 binding to the epithelium and for airway branchingKonstantin I Izvolsky
Pulmonary Ctr, Boston Univ School of Medicine, 80 E Concord St R 304, Boston, MA 02118, USA
Am J Physiol Lung Cell Mol Physiol 285:L838-46. 2003Fibroblast growth factor (Fgf) 10 is a critical regulator of bud formation during lung morphogenesis. fgf10 is expressed in distal lung mesenchyme at sites of prospective budding from the earliest developmental stages and signals through ..
- Fibroblast growth factor receptor-3 is expressed in undifferentiated intestinal epithelial cells during murine crypt morphogenesisAlda Vidrich
Digestive Health Center of Excellence, University of Virginia, Charlottesville, Virginia 22908, USA
Dev Dyn 230:114-23. 2004..These data suggest that signaling through FGFR-3 plays a role in regulating morphogenic events involved in formation of intestinal crypts and/or the fate of epithelial stem cells...
- The mapping of the gene of susceptibility to catalepsy in mice using polymorphic microsatellite markersA V Kulikov
Institute of Cytology and Genetics, Siberian Division, Russian Academy of Sciences, pr. Akademika Lavrent'eva 10, Novosibirsk, 630090 Russia
Dokl Biol Sci 393:531-4. 2003
- Transgenic expression of FGF8 and FGF10 induces transdifferentiation of pancreatic islet cells into hepatocytes and exocrine cellsTakashi Yamaoka
Division of Genetic Information, Institute for Genome Research, University of Tokushima, Tokushima 770 8503, Japan
Biochem Biophys Res Commun 292:138-43. 2002..To examine the effects of overexpressed FGF8 and FGF10 on pancreatic development, we generated FGF8- and FGF10-transgenic mice (Tg mice) under the control of the ..
- Cellular and molecular mechanisms of development of the external genitaliaGen Yamada
Center for Animal Resources and Development CARD and Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University, Honjo, Kumamoto 860 0811, Japan
Differentiation 71:445-60. 2003....
- Tumor chemopreventive activity of 3-O-acylated (--)-epigallocatechinsAyako Kumagai
Department of Biotechnology, Faculty of Engineering, Kansai University, Suita, Osaka 564 8680, Japan
Bioorg Med Chem 11:5143-8. 2003..As a result, these derivatives inhibited a papilloma formation 1.3-1.6-fold more strongly than (--)-epigallocatechin gallate well established as anti-tumor promoter...
- Defective terminal differentiation and hypoplasia of the epidermis in mice lacking the Fgf10 geneK Suzuki
Center for Animal Resources and Development, Kumamoto University, Japan
FEBS Lett 481:53-6. 2000Here, we characterized the skin and hair phenotype of mice lacking the fibroblast growth factor 10 gene (Fgf10), a newly identified member of the fibroblast growth factor family...
- Expression and function of FGF10 in mammalian inner ear developmentSarah Pauley
Creighton University, Department of Biomedical Sciences, Omaha, Nebraska 68178, USA
Dev Dyn 227:203-15. 2003We have investigated the expression of FGF10 during ear development and the effect of an FGF10 null mutation on ear development...
- Evidence that Fgf10 contributes to the skeletal and visceral defects of an Apert syndrome mouse modelMohammad K Hajihosseini
School of Biological Sciences, University of East Anglia, Norwich, United Kingdom
Dev Dyn 238:376-85. 2009..We have generated mice that harbour an AS mutation but are deficient in or heterozygous for Fgf10. The genetic knockdown of Fgf10 can rescue the skeletal as well as some of the visceral defects observed in this ..
- FGFR1 is required for the development of the auditory sensory epitheliumUlla Pirvola
Institute of Biotechnology, 00014 University of Helsinki, Helsinki, Finland
Neuron 35:671-80. 2002..Our data also suggest that FGFR1 might have a distinct later role in intercellular signaling within the differentiating auditory sensory epithelium...
- Reciprocal epithelial-mesenchymal FGF signaling is required for cecal developmentXiuqin Zhang
Department of Molecular Biology and Pharmacology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
Development 133:173-80. 2006..In the gastrointestinal (GI) tract, FGF10 is expressed in the cecal mesenchyme and signals to an epithelial splice form of FGF receptor (FGFR) 2 to regulate ..
- The role of neural crest during cardiac development in a mouse model of DiGeorge syndromeLazaros Kochilas
Cardiovascular Division, University of Pennsylvania, Philadelphia 19104, USA
Dev Biol 251:157-66. 2002..Based on our studies, we propose that Lgdel genes are required for the expression of soluble signals that regulate neural crest cell differentiation...
- Notch signaling regulates pituitary gland organogenesisLori Raetzman; Fiscal Year: 2009..They may also reveal genetic causes of congenital pituitary hormone deficiency and pituitary tumorigenesis and offer novel insight into the function of Notch signaling in endocrine cell differentiation. ..
- Fetal Lung Development:Role of Wnt5a SignalingChanggong Li; Fiscal Year: 2007..This information will be of utility in understanding the molecular mechanisms of congenital and induced lung disease. ..
- Eda/Edar Regulation of Embryonic SMG DevelopmentTina Jaskoll; Fiscal Year: 2007....
- Role of microRNAs in mammalian ear development and neurosensory specificationGarrett A Soukup; Fiscal Year: 2010..Understanding how these small RNAs influence such processes is expected to impact molecular therapeutic strategies designed to regenerate sensory cells and restoring hearing. ..
- Role of homeobox proteins in muscle developmentHelen P Makarenkova; Fiscal Year: 2010..Defining the roles of Barx2 in muscle development, function and repair should help to build a more complete understanding of the muscle regulatory network that may aid in diagnosing or treating muscle disease. ..
- Notch Sigaling in Morphogenesis of Mouse ProstateIrina Grishina; Fiscal Year: 2007..In perspective, those results may aid towards novel therapies to overcome genetic or injury inflicted pathologies in branched glands. ..
- The function of Foxi3 in craniofacial developmentTakahiro Ohyama; Fiscal Year: 2007..This project has significant potential for the future study of craniofacial and sensory organ development that will shed light on the genetic mechanisms of craniofacial birth defects. ..
- COBRE: CREIGHTON UNIVERISTY: P1:ROLE OF MICRORNAS IN DEVELOPMENT OF THE EARGarrett A Soukup; Fiscal Year: 2009..Specific Aim 3. To identify downstream effector genes through which EGFR regulates the development of the PNS. ..