Gene Symbol: Fgf10
Description: fibroblast growth factor 10
Alias: AEY17, BB213776, Fgf-10, Gsfaey17, fibroblast growth factor 10, keratinocyte growth factor 2
Species: mouse
Products:     Fgf10

Top Publications

  1. Abler L, Mansour S, Sun X. Conditional gene inactivation reveals roles for Fgf10 and Fgfr2 in establishing a normal pattern of epithelial branching in the mouse lung. Dev Dyn. 2009;238:1999-2013 pubmed publisher
    b>Fibroblast growth factor 10 (FGF10) signaling through FGF receptor 2 (FGFR2) is required for lung initiation...
  2. Parsa S, Ramasamy S, De Langhe S, Gupte V, Haigh J, Medina D, et al. Terminal end bud maintenance in mammary gland is dependent upon FGFR2b signaling. Dev Biol. 2008;317:121-31 pubmed publisher
    We previously demonstrated that Fibroblast Growth Factor 10 (FGF10) and its receptor FGFR2b play a key role in controlling the very early stages of mammary gland development during embryogenesis [Mailleux, A.A., Spencer-Dene, B...
  3. Que J, Okubo T, Goldenring J, Nam K, Kurotani R, Morrisey E, et al. Multiple dose-dependent roles for Sox2 in the patterning and differentiation of anterior foregut endoderm. Development. 2007;134:2521-31 pubmed
    ..These findings suggest that Sox2 plays a second role in establishing the boundary between the keratinized, squamous esophagus/forestomach and glandular hindstomach. ..
  4. Ryckebusch L, Wang Z, Bertrand N, Lin S, Chi X, Schwartz R, et al. Retinoic acid deficiency alters second heart field formation. Proc Natl Acad Sci U S A. 2008;105:2913-8 pubmed publisher
    ..exhibited a posterior expansion of anterior markers of the SHF, including Tbx1, Fgf8, and the Mlc1v-nlacZ-24/Fgf10 reporter transgene as well as of Islet1...
  5. Fairbanks T, Kanard R, Del Moral P, Sala F, De Langhe S, Lopez C, et al. Colonic atresia without mesenteric vascular occlusion. The role of the fibroblast growth factor 10 signaling pathway. J Pediatr Surg. 2005;40:390-6 pubmed
    ..Prenatal expression of fibroblast growth factor 10 (Fgf10), acting through fibroblast growth factor receptor 2b (Fgfr2b), is critical to the normal ..
  6. Lebeche D, Malpel S, Cardoso W. Fibroblast growth factor interactions in the developing lung. Mech Dev. 1999;86:125-36 pubmed
    ..Our data support a model in which Shh, TGFbeta-1 and BMP-4 counteract the bud promoting effects of FGF-10, and where FGF levels are maintained throughout lung development by other FGFs and Shh. ..
  7. Klein O, Minowada G, Peterkova R, Kangas A, Yu B, Lesot H, et al. Sprouty genes control diastema tooth development via bidirectional antagonism of epithelial-mesenchymal FGF signaling. Dev Cell. 2006;11:181-90 pubmed
  8. Ladher R, Wright T, Moon A, Mansour S, Schoenwolf G. FGF8 initiates inner ear induction in chick and mouse. Genes Dev. 2005;19:603-13 pubmed
    ..In mouse, mesodermal Fgf10 acting redundantly with neural Fgf3 is required for induction of the placode...
  9. Pirvola U, Spencer Dene B, Xing Qun L, Kettunen P, Thesleff I, Fritzsch B, et al. FGF/FGFR-2(IIIb) signaling is essential for inner ear morphogenesis. J Neurosci. 2000;20:6125-34 pubmed
    Interactions between FGF10 and the IIIb isoform of FGFR-2 appear to be crucial for the induction and growth of several organs, particularly those that involve budding morphogenesis...

More Information


  1. Kettunen P, Laurikkala J, Itäranta P, Vainio S, Itoh N, Thesleff I. Associations of FGF-3 and FGF-10 with signaling networks regulating tooth morphogenesis. Dev Dyn. 2000;219:322-32 pubmed
    ..The dynamic expression patterns of different Fgfs in dental epithelium and mesenchyme and their interactions suggest existence of regulatory signaling cascades between epithelial and mesenchymal FGFs during tooth development. ..
  2. Nam J, Park E, Turcotte T, Palencia S, Zhan X, Lee J, et al. Mouse R-spondin2 is required for apical ectodermal ridge maintenance in the hindlimb. Dev Biol. 2007;311:124-35 pubmed
    ..Our findings strongly suggest that Rspo2 expression in the AER is required for AER maintenance likely by regulating Wnt/beta-catenin signaling. ..
  3. Nie X. Apoptosis, proliferation and gene expression patterns in mouse developing tongue. Anat Embryol (Berl). 2005;210:125-32 pubmed
    ..High expression of Fgf7 and Fgf10 was also detected in the mesenchyme at the early embryonic stage of tongue development, corresponding to the Fgfr ..
  4. Hatch E, Noyes C, Wang X, Wright T, Mansour S. Fgf3 is required for dorsal patterning and morphogenesis of the inner ear epithelium. Development. 2007;134:3615-25 pubmed
    ..Finally, we show that Fgf3 prevents ventral expansion of r5-6 neurectodermal Wnt3a, serving to focus inductive WNT signals on the dorsal otic vesicle and highlighting a new example of cross-talk between the two signaling systems. ..
  5. Harada H, Toyono T, Toyoshima K, Ohuchi H. FGF10 maintains stem cell population during mouse incisor development. Connect Tissue Res. 2002;43:201-4 pubmed
    ..At E14, Fgf10 and Fgf3 were coexpressed in the dental papilla...
  6. Kawakami Y, Marti M, Kawakami H, Itou J, Quach T, Johnson A, et al. Islet1-mediated activation of the ?-catenin pathway is necessary for hindlimb initiation in mice. Development. 2011;138:4465-73 pubmed publisher
    ..active proliferation of hindlimb progenitors in the lateral plate mesoderm and the expression of a common factor, Fgf10. Our data demonstrate that Islet1 and ?-catenin regulate outgrowth and Fgf10-Fgf8 feedback loop formation during ..
  7. Min H, Danilenko D, Scully S, Bolon B, Ring B, Tarpley J, et al. Fgf-10 is required for both limb and lung development and exhibits striking functional similarity to Drosophila branchless. Genes Dev. 1998;12:3156-61 pubmed
    ..The pulmonary phenotype of Fgf-10(-/-) mice is strikingly similar to that of the Drosophila mutant branchless, an Fgf homolog. ..
  8. Goss A, Tian Y, Tsukiyama T, Cohen E, Zhou D, Lu M, et al. Wnt2/2b and beta-catenin signaling are necessary and sufficient to specify lung progenitors in the foregut. Dev Cell. 2009;17:290-8 pubmed publisher
    ..Together, these data reveal that canonical Wnt2/2b signaling is required for the specification of lung endoderm progenitors in the developing foregut...
  9. Randall V, McCue K, Roberts C, Kyriakopoulou V, Beddow S, Barrett A, et al. Great vessel development requires biallelic expression of Chd7 and Tbx1 in pharyngeal ectoderm in mice. J Clin Invest. 2009;119:3301-10 pubmed publisher
    ..We could not rescue PAA morphogenesis by restoring neural crest Chd7 expression. Rather, biallelic expression of Chd7 and Tbx1 in the pharyngeal ectoderm was required for normal PAA development...
  10. Jaskoll T, Witcher D, Toreno L, Bringas P, Moon A, Melnick M. FGF8 dose-dependent regulation of embryonic submandibular salivary gland morphogenesis. Dev Biol. 2004;268:457-69 pubmed
    ..Furthermore, since FGF10 and Shh expression is modulated by Fgf8 levels, we postulated that exogenous FGF10, Shh, or FGF10 + Shh peptide ..
  11. Yamamoto N, Chang W, Kelley M. Rbpj regulates development of prosensory cells in the mammalian inner ear. Dev Biol. 2011;353:367-79 pubmed publisher
    ..These results suggest important roles for Rbpj and notch signaling in multiple aspects of inner ear development including prosensory cell maturation, cellular differentiation and survival. ..
  12. Mailleux A, Tefft D, Ndiaye D, Itoh N, Thiery J, Warburton D, et al. Evidence that SPROUTY2 functions as an inhibitor of mouse embryonic lung growth and morphogenesis. Mech Dev. 2001;102:81-94 pubmed
    ..We and others have shown that Fibroblast Growth Factor 10 (FGF10) is a key positive regulator of lung branching morphogenesis...
  13. Moon A, Capecchi M. Fgf8 is required for outgrowth and patterning of the limbs. Nat Genet. 2000;26:455-9 pubmed
    ..Lack of Fgf8 in the apical ectodermal ridge (AER) alters expression of other Fgf genes, Shh and Bmp2. ..
  14. Boulet A, Moon A, Arenkiel B, Capecchi M. The roles of Fgf4 and Fgf8 in limb bud initiation and outgrowth. Dev Biol. 2004;273:361-72 pubmed
    ..mesoderm (IM) has been proposed to play a critical role in the initiation of limb bud outgrowth via restriction of Fgf10 expression to the appropriate region of the lateral plate mesoderm...
  15. Urness L, Paxton C, Wang X, Schoenwolf G, Mansour S. FGF signaling regulates otic placode induction and refinement by controlling both ectodermal target genes and hindbrain Wnt8a. Dev Biol. 2010;340:595-604 pubmed publisher
    ..Mouse embryos lacking both Fgf3 and Fgf10 fail to initiate inner ear development because appropriate patterns of gene expression fail to be specified within ..
  16. Sun X, Lewandoski M, Meyers E, Liu Y, Maxson R, Martin G. Conditional inactivation of Fgf4 reveals complexity of signalling during limb bud development. Nat Genet. 2000;25:83-6 pubmed
  17. Izvolsky K, Shoykhet D, Yang Y, Yu Q, Nugent M, Cardoso W. Heparan sulfate-FGF10 interactions during lung morphogenesis. Dev Biol. 2003;258:185-200 pubmed
    Signaling by fibroblast growth factor 10 (FGF10) through FGFR2b is essential for lung development...
  18. Patel V, Knox S, Likar K, Lathrop C, Hossain R, Eftekhari S, et al. Heparanase cleavage of perlecan heparan sulfate modulates FGF10 activity during ex vivo submandibular gland branching morphogenesis. Development. 2007;134:4177-86 pubmed
    ..activity in organ culture decreased branching morphogenesis, and this inhibition was rescued specifically by FGF10 and not by other FGFs...
  19. Hart A, Papadopoulou S, Edlund H. Fgf10 maintains notch activation, stimulates proliferation, and blocks differentiation of pancreatic epithelial cells. Dev Dyn. 2003;228:185-93 pubmed
    ..The fibroblast growth factor receptor (FGFR) 2b high-affinity ligand FGF10 has been linked to pancreatic epithelial cell proliferation, and we have shown previously that Notch signalling ..
  20. Theodorou V, Boer M, Weigelt B, Jonkers J, van der Valk M, Hilkens J. Fgf10 is an oncogene activated by MMTV insertional mutagenesis in mouse mammary tumors and overexpressed in a subset of human breast carcinomas. Oncogene. 2004;23:6047-55 pubmed
    ..in mammary tumors from BALB/c mice infected with C3H-MMTV, we have found a common MMTV insertion site in the Fgf10 locus...
  21. de Maximy A, Nakatake Y, Moncada S, Itoh N, Thiery J, Bellusci S. Cloning and expression pattern of a mouse homologue of drosophila sprouty in the mouse embryo. Mech Dev. 1999;81:213-6 pubmed
    ..Sprouty4 expression is also detected in the lateral region of the somites. In the developing lung, Sprouty4 is expressed broadly in the distal mesenchyme. ..
  22. Harada H, Toyono T, Toyoshima K, Yamasaki M, Itoh N, Kato S, et al. FGF10 maintains stem cell compartment in developing mouse incisors. Development. 2002;129:1533-41 pubmed
    ..To further illustrate the role of FGF10 in the formation of the stem cell compartment during tooth organogenesis, we have analyzed incisor development in ..
  23. Vega Hernández M, Kovacs A, De Langhe S, Ornitz D. FGF10/FGFR2b signaling is essential for cardiac fibroblast development and growth of the myocardium. Development. 2011;138:3331-40 pubmed publisher
    ..Here, we identify a myocardial to epicardial fibroblast growth factor (FGF) signal, mediated by FGF10 and FGFR2b, that is essential for movement of cardiac fibroblasts into the compact myocardium...
  24. Frank D, Fotheringham L, Brewer J, Muglia L, Tristani Firouzi M, Capecchi M, et al. An Fgf8 mouse mutant phenocopies human 22q11 deletion syndrome. Development. 2002;129:4591-603 pubmed
    ..and heart due, at least in part, to failure to form the fourth pharyngeal arch arteries, altered expression of Fgf10 in the pharyngeal mesenchyme, and abnormal apoptosis in pharyngeal and cardiac neural crest...
  25. Yokohama Tamaki T, Ohshima H, Fujiwara N, Takada Y, Ichimori Y, Wakisaka S, et al. Cessation of Fgf10 signaling, resulting in a defective dental epithelial stem cell compartment, leads to the transition from crown to root formation. Development. 2006;133:1359-66 pubmed
    ..continuous growth, owing to the formation and maintenance of a stem cell compartment by the constant expression of Fgf10. To clarify the relationship between root formation and disappearance of Fgf10, we carried out two experiments for ..
  26. Bell S, Schreiner C, Scott W. The loss of ventral ectoderm identity correlates with the inability to form an AER in the legless hindlimb bud. Mech Dev. 1998;74:41-50 pubmed
    ..These data suggest that establishment of a dorso-ventral ectodermal interface is not sufficient for AER formation and that restriction of lmx-1b to the dorsal mesenchyme is coordinately linked to AER formation. ..
  27. Volckaert T, Dill E, Campbell A, Tiozzo C, Majka S, Bellusci S, et al. Parabronchial smooth muscle constitutes an airway epithelial stem cell niche in the mouse lung after injury. J Clin Invest. 2011;121:4409-19 pubmed publisher
    During lung development, parabronchial SMC (PSMC) progenitors in the distal mesenchyme secrete fibroblast growth factor 10 (Fgf10), which acts on distal epithelial progenitors to promote their proliferation...
  28. Vitelli F, Viola A, Morishima M, Pramparo T, Baldini A, Lindsay E. TBX1 is required for inner ear morphogenesis. Hum Mol Genet. 2003;12:2041-8 pubmed
    ..Our data suggest that Tbx1 deletion in del22q11 patients may cause not only external and middle ear defects but also sensorineural and vestibular phenotypes observed in these patients. ..
  29. Hajihosseini M, De Langhe S, Lana Elola E, Morrison H, Sparshott N, Kelly R, et al. Localization and fate of Fgf10-expressing cells in the adult mouse brain implicate Fgf10 in control of neurogenesis. Mol Cell Neurosci. 2008;37:857-68 pubmed publisher
    We used Fgf10-lacZ reporter mice to investigate the distribution and fate of Fgf10-expressing cells in the developing and adult mouse brain...
  30. Kelly R, Brown N, Buckingham M. The arterial pole of the mouse heart forms from Fgf10-expressing cells in pharyngeal mesoderm. Dev Cell. 2001;1:435-40 pubmed
    ..The nlacZ transgene has integrated upstream of the fibroblast growth factor 10 (Fgf10) gene and comparison with the expression pattern of Fgf10 in pharyngeal mesoderm indicates ..
  31. Govindarajan V, Ito M, Makarenkova H, Lang R, Overbeek P. Endogenous and ectopic gland induction by FGF-10. Dev Biol. 2000;225:188-200 pubmed
    ..In addition, lacrimal and Harderian glands were not seen in FGF-10 null fetuses. Based on these results we propose that FGF-10 is an inductive signal that initiates ocular gland morphogenesis...
  32. Hosokawa R, Oka K, Yamaza T, Iwata J, Urata M, Xu X, et al. TGF-beta mediated FGF10 signaling in cranial neural crest cells controls development of myogenic progenitor cells through tissue-tissue interactions during tongue morphogenesis. Dev Biol. 2010;341:186-95 pubmed publisher
    ..Loss of Tgfbr2 in CNC cells (Wnt1-Cre;Tgfbr2(flox/flox)) results in microglossia with reduced Scleraxis and Fgf10 expression as well as decreased myogenic cell proliferation, reduced cell number and disorganized tongue muscles...
  33. Rochais F, Dandonneau M, Mesbah K, Jarry T, Mattei M, Kelly R. Hes1 is expressed in the second heart field and is required for outflow tract development. PLoS ONE. 2009;4:e6267 pubmed publisher
    ..Hes1 is expressed in cardiac progenitor cells in the early embryo and is required for development of the arterial pole of the heart. ..
  34. Klar J, Blomstrand P, Brunmark C, Badhai J, Håkansson H, Brange C, et al. Fibroblast growth factor 10 haploinsufficiency causes chronic obstructive pulmonary disease. J Med Genet. 2011;48:705-9 pubmed publisher
    ..The fibroblast growth factor 10 (FGF10) signalling pathway is critical for lung development and lung epithelial renewal...
  35. Tsau C, Ito M, Gromova A, Hoffman M, Meech R, Makarenkova H. Barx2 and Fgf10 regulate ocular glands branching morphogenesis by controlling extracellular matrix remodeling. Development. 2011;138:3307-17 pubmed publisher
    ..Fibroblast growth factors are crucial regulators of LG development and we show that Barx2 is required for Fgf10-induced LG bud elongation and that both Barx2 and Fgf10 cooperate in the regulation of MMPs...
  36. Agarwal P, Wylie J, Galceran J, Arkhitko O, Li C, Deng C, et al. Tbx5 is essential for forelimb bud initiation following patterning of the limb field in the mouse embryo. Development. 2003;130:623-33 pubmed
    ..the FGF and Wnt regulatory loops required for limb bud outgrowth are not established, including initiation of Fgf10 expression...
  37. Wright T, Mansour S. Fgf3 and Fgf10 are required for mouse otic placode induction. Development. 2003;130:3379-90 pubmed
    ..We show here that mouse Fgf10 is expressed in the mesenchyme underlying the prospective otic placode...
  38. Naiche L, Papaioannou V. Loss of Tbx4 blocks hindlimb development and affects vascularization and fusion of the allantois. Development. 2003;130:2681-93 pubmed
    ..However, hindlimb buds from Tbx4 mutants fail to develop either in vivo or in vitro and do not maintain Fgf10 expression in the mesenchyme...
  39. Mailleux A, Kelly R, Veltmaat J, De Langhe S, Zaffran S, Thiery J, et al. Fgf10 expression identifies parabronchial smooth muscle cell progenitors and is required for their entry into the smooth muscle cell lineage. Development. 2005;132:2157-66 pubmed
    ..Using a transgenic mouse line expressing LacZ under the control of Fgf10 regulatory sequences, we show that the pool of Fgf10-positive cells in the distal lung mesenchyme contains ..
  40. Funato N, Nakamura M, Richardson J, Srivastava D, Yanagisawa H. Tbx1 regulates oral epithelial adhesion and palatal development. Hum Mol Genet. 2012;21:2524-37 pubmed publisher
    ..Our present study reveals new pathogenesis of incomplete and submucous cleft palate during mammalian palatogenesis. ..
  41. Donjacour A, Thomson A, Cunha G. FGF-10 plays an essential role in the growth of the fetal prostate. Dev Biol. 2003;261:39-54 pubmed
    ..FGF-10 alone did not stimulate prostatic bud formation in control or FGF-10(-/-) UGS. Thus, FGF-10 appears to act as a growth factor which is required for development of the prostate and several other accessory sex organs. ..
  42. Entesarian M, Matsson H, Klar J, Bergendal B, Olson L, Arakaki R, et al. Mutations in the gene encoding fibroblast growth factor 10 are associated with aplasia of lacrimal and salivary glands. Nat Genet. 2005;37:125-7 pubmed
    ..We mapped ALSG to 5p13.2-5q13.1, which coincides with the gene fibroblast growth factor 10 (FGF10)...
  43. Sala F, Curtis J, Veltmaat J, del Moral P, Le L, Fairbanks T, et al. Fibroblast growth factor 10 is required for survival and proliferation but not differentiation of intestinal epithelial progenitor cells during murine colon development. Dev Biol. 2006;299:373-85 pubmed
    ..In this study, we determine the temporal-spatial expression pattern of Fibroblast growth factor 10 (Fgf10), a key developmental gene, in the colon at different developmental stages...
  44. Parsa S, Kuremoto K, Seidel K, Tabatabai R, MacKenzie B, Yamaza T, et al. Signaling by FGFR2b controls the regenerative capacity of adult mouse incisors. Development. 2010;137:3743-52 pubmed publisher
    ..Previous studies have suggested that FGF10, acting mainly through fibroblast growth factor receptor 2b (FGFR2b), is crucial for development of the epithelial ..
  45. Colvin J, White A, Pratt S, Ornitz D. Lung hypoplasia and neonatal death in Fgf9-null mice identify this gene as an essential regulator of lung mesenchyme. Development. 2001;128:2095-106 pubmed
    ..Fibroblast growth factors (FGFs) often mediate epithelial-mesenchymal interactions and mesenchymal Fgf10 is essential for epithelial branching in the developing lung...
  46. Xu X, Weinstein M, Li C, Naski M, Cohen R, Ornitz D, et al. Fibroblast growth factor receptor 2 (FGFR2)-mediated reciprocal regulation loop between FGF8 and FGF10 is essential for limb induction. Development. 1998;125:753-65 pubmed
    ..of Fgf8, an apical ectodermal factor, is absent in the mutant presumptive limb ectoderm, and the expression of Fgf10, a mesenchymally expressed limb bud initiator, is down regulated in the underlying mesoderm...
  47. Jaskoll T, Abichaker G, Witcher D, Sala F, Bellusci S, Hajihosseini M, et al. FGF10/FGFR2b signaling plays essential roles during in vivo embryonic submandibular salivary gland morphogenesis. BMC Dev Biol. 2005;5:11 pubmed
    Analyses of Fgf10 and Fgfr2b mutant mice, as well as human studies, suggest that FGF10/FGFR2b signaling may play an essential, nonredundant role during embryonic SMG development...
  48. Norgaard G, Jensen J, Jensen J. FGF10 signaling maintains the pancreatic progenitor cell state revealing a novel role of Notch in organ development. Dev Biol. 2003;264:323-38 pubmed
    b>FGF10 plays an important role in the morphogenesis of several tissues by control of mesenchymal-to-epithelial signaling...
  49. White A, Xu J, Yin Y, Smith C, Schmid G, Ornitz D. FGF9 and SHH signaling coordinate lung growth and development through regulation of distinct mesenchymal domains. Development. 2006;133:1507-17 pubmed
  50. Vainio S, Karavanova I, Jowett A, Thesleff I. Identification of BMP-4 as a signal mediating secondary induction between epithelial and mesenchymal tissues during early tooth development. Cell. 1993;75:45-58 pubmed
    ..In addition, BMP-4 induced its own mesenchymal expression. These findings support the hypothesis that BMP-4 mediates epithelial-mesenchymal interactions during early tooth development. ..
  51. Yang L, Cai C, Lin L, Qyang Y, Chung C, Monteiro R, et al. Isl1Cre reveals a common Bmp pathway in heart and limb development. Development. 2006;133:1575-85 pubmed
    ..Tbx3 is required for heart and limb formation, and is mutated in ulnar-mammary syndrome. We provide evidence that the Tbx3 promoter is directly regulated by Bmp Smads in vivo. ..
  52. Mailleux A, Spencer Dene B, Dillon C, Ndiaye D, Savona Baron C, Itoh N, et al. Role of FGF10/FGFR2b signaling during mammary gland development in the mouse embryo. Development. 2002;129:53-60 pubmed
    ..placode development using Lef1 as a marker for the epithelial component of the placode, and mice deficient for Fgf10 or Fgfr2b, both of which fail to develop normal mammary glands...
  53. Harrelson Z, Kelly R, Goldin S, Gibson Brown J, Bollag R, Silver L, et al. Tbx2 is essential for patterning the atrioventricular canal and for morphogenesis of the outflow tract during heart development. Development. 2004;131:5041-52 pubmed
  54. Ohyama T, Basch M, Mishina Y, Lyons K, Segil N, Groves A. BMP signaling is necessary for patterning the sensory and nonsensory regions of the developing mammalian cochlea. J Neurosci. 2010;30:15044-51 pubmed publisher
    ..Our results suggest BMP signaling is required for patterning sensory and nonsensory tissue in the mammalian cochlea. ..
  55. Barrow J, Thomas K, Boussadia Zahui O, Moore R, Kemler R, Capecchi M, et al. Ectodermal Wnt3/beta-catenin signaling is required for the establishment and maintenance of the apical ectodermal ridge. Genes Dev. 2003;17:394-409 pubmed
    ..Finally, we demonstrate that Wnt/beta-catenin signaling lies upstream of the Bmp signaling pathway in establishment of the AER and regulation of the dorsoventral polarity of the limb. ..
  56. Watanabe Y, Miyagawa Tomita S, Vincent S, Kelly R, Moon A, Buckingham M. Role of mesodermal FGF8 and FGF10 overlaps in the development of the arterial pole of the heart and pharyngeal arch arteries. Circ Res. 2010;106:495-503 pubmed publisher
    ..and conditional Fgf8 mutants show disrupted outflow tract (OFT) and right ventricle (RV) development, whereas Fgf10 mutants do not have detectable OFT defects...
  57. Cebra Thomas J, Bromer J, Gardner R, Lam G, Sheipe H, Gilbert S. T-box gene products are required for mesenchymal induction of epithelial branching in the embryonic mouse lung. Dev Dyn. 2003;226:82-90 pubmed
    ..Mesenchymal FGF10 is known to be an important paracrine factor regulating the branching morphogenesis of the bronchial epithelium...
  58. Hajihosseini M, Wilson S, De Moerlooze L, Dickson C. A splicing switch and gain-of-function mutation in FgfR2-IIIc hemizygotes causes Apert/Pfeiffer-syndrome-like phenotypes. Proc Natl Acad Sci U S A. 2001;98:3855-60 pubmed
    ..This phenotype has strong parallels to some Apert's and Pfeiffer's syndrome patients...
  59. Seymour P, Shih H, Patel N, Freude K, Xie R, Lim C, et al. A Sox9/Fgf feed-forward loop maintains pancreatic organ identity. Development. 2012;139:3363-72 pubmed publisher
    ..loss of the fibroblast growth factor receptor (Fgfr) 2b, which is required for transducing mesenchymal Fgf10 signals...
  60. Yin Y, White A, Huh S, Hilton M, Kanazawa H, Long F, et al. An FGF-WNT gene regulatory network controls lung mesenchyme development. Dev Biol. 2008;319:426-36 pubmed publisher
    ..Together, both FGF and WNT signaling pathways function to sustain mesenchymal growth and coordinate epithelial morphogenesis during the pseudoglandular stage of lung development. ..
  61. Beer H, Florence C, Dammeier J, McGuire L, Werner S, Duan D. Mouse fibroblast growth factor 10: cDNA cloning, protein characterization, and regulation of mRNA expression. Oncogene. 1997;15:2211-8 pubmed
    ..These results demonstrate a differential regulation of mFGF-10 and FGF-7 expression in vitro and during the wound healing process. ..
  62. Nitta M, Kume T, Nogawa H. FGF alters epithelial competence for EGF at the initiation of branching morphogenesis of mouse submandibular gland. Dev Dyn. 2009;238:315-23 pubmed publisher
    ..branching occurred under the same culture conditions; however, both E12 and E13 epithelia elongated in response to FGF10. Reverse transcriptase-polymerase chain reaction studies showed that the expression of ErbB1 among four EGF ..
  63. Bellusci S, Grindley J, Emoto H, Itoh N, Hogan B. Fibroblast growth factor 10 (FGF10) and branching morphogenesis in the embryonic mouse lung. Development. 1997;124:4867-78 pubmed
    ..We report here that fibroblast growth factor 10 (Fgf10) is expressed dynamically in the mesenchyme adjacent to the distal buds from the earliest stages ..
  64. Li C, Xiao J, Hormi K, Borok Z, Minoo P. Wnt5a participates in distal lung morphogenesis. Dev Biol. 2002;248:68-81 pubmed
    ..Absence of WNT5a activity in the mutant lungs leads to increased expression of Fgf-10, Bmp4, Shh, and its receptor Ptc, raising the possibility that WNT5a, FGF-10, BMP4, and SHH signaling pathways are functionally interactive. ..
  65. Alvarez Y, Alonso M, Vendrell V, Zelarayan L, Chamero P, Theil T, et al. Requirements for FGF3 and FGF10 during inner ear formation. Development. 2003;130:6329-38 pubmed
    ..Ectopic expression of FGF10 in the developing hindbrain of transgenic mice leads to the formation of ectopic vesicles, expressing some otic ..
  66. Haraguchi R, Suzuki K, Murakami R, Sakai M, Kamikawa M, Kengaku M, et al. Molecular analysis of external genitalia formation: the role of fibroblast growth factor (Fgf) genes during genital tubercle formation. Development. 2000;127:2471-9 pubmed
    ..in the distal urethral plate epithelium of the genital tubercle (GT) together with other markers such as the Msx1, Fgf10, Hoxd13 and Bmp4 expressed in the mesenchyme...
  67. Tai C, Curtis J, Sala F, Del Moral P, Chokshi N, Kanard R, et al. Induction of fibroblast growth factor 10 (FGF10) in the ileal crypt epithelium after massive small bowel resection suggests a role for FGF10 in gut adaptation. Dev Dyn. 2009;238:294-301 pubmed publisher
    We have previously reported that fibroblast growth factor 10 (FGF10) is crucial for the survival and proliferation of progenitor cells during embryonic gastrointestinal development...
  68. Cai C, Liang X, Shi Y, Chu P, Pfaff S, Chen J, et al. Isl1 identifies a cardiac progenitor population that proliferates prior to differentiation and contributes a majority of cells to the heart. Dev Cell. 2003;5:877-89 pubmed
    ..Our results have implications for the development of specific cardiac lineages, left-right asymmetry, cardiac evolution, and isolation of cardiac progenitor cells. ..
  69. Park W, Miranda B, Lebeche D, Hashimoto G, Cardoso W. FGF-10 is a chemotactic factor for distal epithelial buds during lung development. Dev Biol. 1998;201:125-34 pubmed
  70. Ohuchi H, Yasue A, Ono K, Sasaoka S, Tomonari S, Takagi A, et al. Identification of cis-element regulating expression of the mouse Fgf10 gene during inner ear development. Dev Dyn. 2005;233:177-87 pubmed
    ..Here, we report the abnormality of Fgf10 null ear and the identification of a cis-regulatory element directing otic expression of Fgf10...
  71. Harris Johnson K, Domyan E, Vezina C, Sun X. beta-Catenin promotes respiratory progenitor identity in mouse foregut. Proc Natl Acad Sci U S A. 2009;106:16287-92 pubmed publisher
    ..Our findings reveal an early role for beta-Catenin in the establishment of respiratory progenitors in mouse foregut endoderm. ..
  72. Treichel D, Schock F, Jackle H, Gruss P, Mansouri A. mBtd is required to maintain signaling during murine limb development. Genes Dev. 2003;17:2630-5 pubmed
    ..The data indicate that mBtd represents a novel key player mediating proximodistal outgrowth of the limb. ..
  73. Ohuchi H, Tao H, Ohata K, Itoh N, Kato S, Noji S, et al. Fibroblast growth factor 10 is required for proper development of the mouse whiskers. Biochem Biophys Res Commun. 2003;302:562-7 pubmed
    ..To elucidate the role of FGF10 during whisker formation, we examined the expression of Fgf10 in normal developing whiskers and phenotypes of ..
  74. Choi K, Lee C, Maatouk D, Harfe B. Bmp2, Bmp4 and Bmp7 are co-required in the mouse AER for normal digit patterning but not limb outgrowth. PLoS ONE. 2012;7:e37826 pubmed publisher
    ..These data suggest that Bmp ligands expressed in the AER are not required for limb outgrowth but instead play an essential role in maintaining the AER and patterning vertebrate digits. ..
  75. Arora R, Metzger R, Papaioannou V. Multiple roles and interactions of Tbx4 and Tbx5 in development of the respiratory system. PLoS Genet. 2012;8:e1002866 pubmed publisher
    ..Concordant with this defect, the expression of mesenchymal markers Wnt2 and Fgf10, as well as Fgf10 target genes Bmp4 and Spry2, in the epithelium is downregulated...
  76. del Moral P, De Langhe S, Sala F, Veltmaat J, Tefft D, Wang K, et al. Differential role of FGF9 on epithelium and mesenchyme in mouse embryonic lung. Dev Biol. 2006;293:77-89 pubmed
    ..At the molecular level, FGF9 up-regulates Fgf10 expression in the mesenchyme likely via increased expression of Tbx4 and 5 and controls the transcription of ..
  77. Liu Y, Liu C, Yamada Y, Fan C. Growth arrest specific gene 1 acts as a region-specific mediator of the Fgf10/Fgf8 regulatory loop in the limb. Development. 2002;129:5289-300 pubmed
    Proximal-to-distal growth of the embryonic limbs requires Fgf10 in the mesenchyme to activate Fgf8 in the apical ectodermal ridge (AER), which in turn promotes mesenchymal outgrowth...
  78. Golzio C, Havis E, Daubas P, Nuel G, Babarit C, Munnich A, et al. ISL1 directly regulates FGF10 transcription during human cardiac outflow formation. PLoS ONE. 2012;7:e30677 pubmed publisher
    ..Other markers have been identified that characterize subdomains of the SHF, such as the fibroblast growth factor Fgf10 in its anterior region...
  79. Sun X, Mariani F, Martin G. Functions of FGF signalling from the apical ectodermal ridge in limb development. Nature. 2002;418:501-8 pubmed
    ..In the complete absence of both FGF4 and FGF8 activities, limb development fails. We present a model to explain how the mutant phenotypes arise from FGF-mediated effects on limb bud size and cell survival. ..
  80. Jaskoll T, Zhou Y, Chai Y, Makarenkova H, Collinson J, West J, et al. Embryonic submandibular gland morphogenesis: stage-specific protein localization of FGFs, BMPs, Pax6 and Pax9 in normal mice and abnormal SMG phenotypes in FgfR2-IIIc(+/Delta), BMP7(-/-) and Pax6(-/-) mice. Cells Tissues Organs. 2002;170:83-98 pubmed
    ..Finally, our observations of abnormal SMGs in BMP7(-/-) and Pax6(-/-) indicate that both BMP7 and Pax6 play important roles during embryonic SMG branching morphogenesis. ..
  81. Wang J, Greene S, Bonilla Claudio M, Tao Y, Zhang J, Bai Y, et al. Bmp signaling regulates myocardial differentiation from cardiac progenitors through a MicroRNA-mediated mechanism. Dev Cell. 2010;19:903-12 pubmed publisher
    ..Our findings indicate that Bmp signaling directly regulates a miRNA-mediated effector mechanism that downregulates cardiac progenitor genes and enhances myocardial differentiation. ..
  82. Mucenski M, Wert S, Nation J, Loudy D, Huelsken J, Birchmeier W, et al. beta-Catenin is required for specification of proximal/distal cell fate during lung morphogenesis. J Biol Chem. 2003;278:40231-8 pubmed
    ..These observations establish, for the first time, both the sites and timing of specification of the proximal and peripheral airways in the developing lung, and that beta-catenin is one of the essential components of this specification. ..
  83. Xu H, Morishima M, Wylie J, Schwartz R, Bruneau B, Lindsay E, et al. Tbx1 has a dual role in the morphogenesis of the cardiac outflow tract. Development. 2004;131:3217-27 pubmed
    ..This process might be regulated in part by Fgf10, which we show for the first time to be a direct target of Tbx1 in vitro...
  84. Chang W, Lin Z, Kulessa H, Hebert J, Hogan B, Wu D. Bmp4 is essential for the formation of the vestibular apparatus that detects angular head movements. PLoS Genet. 2008;4:e1000050 pubmed publisher
    ..regulating genes required for prosensory development in the inner ear such as Serrate1 (Jagged1 in mouse), Fgf10, and Sox2...
  85. Marguerie A, Bajolle F, Zaffran S, Brown N, Dickson C, Buckingham M, et al. Congenital heart defects in Fgfr2-IIIb and Fgf10 mutant mice. Cardiovasc Res. 2006;71:50-60 pubmed
    Myocardial progenitor cells expressing Fgf10 give rise to the outflow tract and right ventricle of the mammalian heart...
  86. Tiozzo C, De Langhe S, Carraro G, Alam D, Nagy A, Wigfall C, et al. Fibroblast growth factor 10 plays a causative role in the tracheal cartilage defects in a mouse model of Apert syndrome. Pediatr Res. 2009;66:386-90 pubmed publisher
    ..that tracheal stenosis is associated with increased proliferation of mesenchymal cells, where the expression of Fgf10 and its upstream regulators Tbx4 and Tbx5 are abnormally elevated...