Gene Symbol: Fgf1
Description: fibroblast growth factor 1
Alias: Dffrx, Fam, Fgf-1, Fgfa, fibroblast growth factor 1, HBGF-1, aFGF, acidic fibroblast growth factor, fibroblast growth factor 1 (acidic), heparin-binding growth factor 1
Species: mouse
Products:     Fgf1

Top Publications

  1. Cox R, Copeland N, Jenkins N, Lehrach H. Interspersed repetitive element polymerase chain reaction product mapping using a mouse interspecific backcross. Genomics. 1991;10:375-84 pubmed
    ..We anticipate that many more markers remain to be characterized in this valuable new source of polymorphism. ..
  2. Justice M, Gilbert D, Kinzler K, Vogelstein B, Buchberg A, Ceci J, et al. A molecular genetic linkage map of mouse chromosome 18 reveals extensive linkage conservation with human chromosomes 5 and 18. Genomics. 1992;13:1281-8 pubmed
    ..The Apc, Camk2a, D18Fcr1, D18Fcr2, D18Leh1, D18Leh2, Dcc, Emb-rs3, Fgfa, Fim-2/Csfmr, Gnal, Grl-1, Grp, Hk-1rs1, Ii, Kns, Lmnb, Mbp, Mcc, Mtv-38, Palb, Pdgfrb, and Tpl-2 genes were mapped ..
  3. Nilsen T, Rosendal K, Sørensen V, Wesche J, Olsnes S, Wiedłocha A. A nuclear export sequence located on a beta-strand in fibroblast growth factor-1. J Biol Chem. 2007;282:26245-56 pubmed
    ..The FGF-1 NES was found to be situated along a beta-strand, which has not been reported before, since NESs usually are alpha-helical. ..
  4. Nurcombe V, Ford M, Wildschut J, Bartlett P. Developmental regulation of neural response to FGF-1 and FGF-2 by heparan sulfate proteoglycan. Science. 1993;260:103-6 pubmed
    ..Thus, a single species of HSPG undergoes a rapid, tightly controlled change in growth factor-binding specificity concomitant with the temporal expression of the FGFs. ..
  5. Sørensen V, Zhen Y, Zakrzewska M, Haugsten E, Walchli S, Nilsen T, et al. Phosphorylation of fibroblast growth factor (FGF) receptor 1 at Ser777 by p38 mitogen-activated protein kinase regulates translocation of exogenous FGF1 to the cytosol and nucleus. Mol Cell Biol. 2008;28:4129-41 pubmed publisher
    Exogenous fibroblast growth factor 1 (FGF1) signals through activation of transmembrane FGF receptors (FGFRs) but may also regulate cellular processes after translocation to the cytosol and nucleus of target cells...
  6. Mailleux A, Kelly R, Veltmaat J, De Langhe S, Zaffran S, Thiery J, et al. Fgf10 expression identifies parabronchial smooth muscle cell progenitors and is required for their entry into the smooth muscle cell lineage. Development. 2005;132:2157-66 pubmed
    ..We provide support for a role of epithelial BMP4 in mediating the formation of parabronchial smooth muscle cells...
  7. Martineau Y, Le Bec C, Monbrun L, Allo V, Chiu I, Danos O, et al. Internal ribosome entry site structural motifs conserved among mammalian fibroblast growth factor 1 alternatively spliced mRNAs. Mol Cell Biol. 2004;24:7622-35 pubmed
    b>Fibroblast growth factor 1 (FGF-1) is a powerful angiogenic factor whose gene structure contains four promoters, giving rise to a process of alternative splicing resulting in four mRNAs with alternative 5' untranslated regions (5' UTRs)...
  8. Zakrzewska M, Sørensen V, Jin Y, Wiedlocha A, Olsnes S. Translocation of exogenous FGF1 into cytosol and nucleus is a periodic event independent of receptor kinase activity. Exp Cell Res. 2011;317:1005-15 pubmed publisher
    b>Fibroblast growth factor 1 (FGF1) has the property to become translocated from the extracellular space into the cell cytosol and nucleus...
  9. Zakrzewska M, Wiedlocha A, Szlachcic A, Krowarsch D, Otlewski J, Olsnes S. Increased protein stability of FGF1 can compensate for its reduced affinity for heparin. J Biol Chem. 2009;284:25388-403 pubmed publisher
    Human FGF1 (fibroblast growth factor 1) is a powerful signaling molecule with a short half-life in vivo and a denaturation temperature close to physiological...

More Information


  1. Itoh N, Ornitz D. Functional evolutionary history of the mouse Fgf gene family. Dev Dyn. 2008;237:18-27 pubmed
    ..subfamily (iFGFs), the hormone-like Fgf15/21/23 subfamily (hFGFs), and the canonical Fgf subfamilies, including Fgf1/2/5, Fgf3/4/6, Fgf7/10/22, Fgf8/17/18, and Fgf9/16/20. However, all Fgfs are evolutionarily related...
  2. Madiai F, Hackshaw K, Chiu I. Characterization of the entire transcription unit of the mouse fibroblast growth factor 1 (FGF-1) gene. Tissue-specific expression of the FGF-1.A mRNA. J Biol Chem. 1999;274:11937-44 pubmed
    b>Fibroblast growth factor 1 (FGF-1, also known as acidic FGF) is a mitogen for a variety of mesoderm- and neuroectoderm-derived cells, as well as an angiogenic factor in vivo...
  3. Mailleux A, Spencer Dene B, Dillon C, Ndiaye D, Savona Baron C, Itoh N, et al. Role of FGF10/FGFR2b signaling during mammary gland development in the mouse embryo. Development. 2002;129:53-60 pubmed
    ..Our results also suggest that FGF signaling is involved in the maintenance of mammary bud 4, and that Fgf10 deficient epithelium can undergo branching morphogenesis into the mammary fat pad precursor. ..
  4. Stavridis M, Lunn J, Collins B, Storey K. A discrete period of FGF-induced Erk1/2 signalling is required for vertebrate neural specification. Development. 2007;134:2889-94 pubmed
  5. Bellusci S, Grindley J, Emoto H, Itoh N, Hogan B. Fibroblast growth factor 10 (FGF10) and branching morphogenesis in the embryonic mouse lung. Development. 1997;124:4867-78 pubmed
    ..This response involves an increase in the rate of endodermal cell proliferation. The activity of FGF1, FGF7 and FGF10 was also tested directly on isolated endoderm in Matrigel culture...
  6. Chiu I, Touhalisky K, Liu Y, Yates A, Frostholm A. Tumorigenesis in transgenic mice in which the SV40 T antigen is driven by the brain-specific FGF1 promoter. Oncogene. 2000;19:6229-39 pubmed
    ..Previously, we have shown that the human FGF1 gene contains four distinct tissue-specific promoters...
  7. Miller D, Ortega S, Bashayan O, Basch R, Basilico C. Compensation by fibroblast growth factor 1 (FGF1) does not account for the mild phenotypic defects observed in FGF2 null mice. Mol Cell Biol. 2000;20:2260-8 pubmed
    b>Fibroblast growth factor 1 (FGF1) and FGF2, the prototypic members of the FGF family of growth factors, have been implicated in a variety of physiological and pathological processes...
  8. Yu C, Wang F, Jin C, Huang X, Miller D, Basilico C, et al. Role of fibroblast growth factor type 1 and 2 in carbon tetrachloride-induced hepatic injury and fibrogenesis. Am J Pathol. 2003;163:1653-62 pubmed
    ..the potential role of all 23 FGF polypeptides in the liver is still unclear, the most widely studied prototypes, FGF1 and FGF2, are present and have been implicated in liver cell growth and function in vitro...
  9. Jonker J, Suh J, Atkins A, Ahmadian M, Li P, Whyte J, et al. A PPAR?-FGF1 axis is required for adaptive adipose remodelling and metabolic homeostasis. Nature. 2012;485:391-4 pubmed publisher
    ..Here we identify fibroblast growth factor 1 (FGF1) as a critical transducer in this process in mice, and link its regulation to the nuclear receptor ..
  10. Duarte M, Kolev V, Soldi R, Kirov A, Graziani I, Oliveira S, et al. Thrombin induces rapid PAR1-mediated non-classical FGF1 release. Biochem Biophys Res Commun. 2006;350:604-9 pubmed
    ..We report that thrombin rapidly stimulated expression and release of the pro-angiogenic polypeptide fibroblast growth factor 1 (FGF1)...
  11. Wiedłocha A, Nilsen T, Wesche J, Sørensen V, Małecki J, Marcinkowska E, et al. Phosphorylation-regulated nucleocytoplasmic trafficking of internalized fibroblast growth factor-1. Mol Biol Cell. 2005;16:794-810 pubmed
    ..The nucleocytoplasmic trafficking of the phosphorylated growth factor is likely to play a role in the activity of internalized FGF-1...
  12. Alam K, Frostholm A, Hackshaw K, Evans J, Rotter A, Chiu I. Characterization of the 1B promoter of fibroblast growth factor 1 and its expression in the adult and developing mouse brain. J Biol Chem. 1996;271:30263-71 pubmed
    The present study elucidates the molecular structure of a murine fibroblast growth factor 1 (FGF-1) promoter and describes its distribution in the adult and developing mouse brain...
  13. Jeremiah S, McCann K, Williams A, Ramsden D, Pilz A, Fox M, et al. Chromosomal localisation of genes coding for human and mouse liver cytosolic cysteine dioxygenase. Ann Hum Genet. 1996;60:29-33 pubmed
    ..Interspecific backcross mapping in the mouse indicated that Cdo, the mouse homologue of CDO, is situated in the central region of mouse chromosome 18 which shares a region of homology with human chromosome 5. ..
  14. Ozawa K, Seo M, Imamura T. A quantitative method for evaluation of FGF family and FGF receptor family gene expression by RT-PCR. Brain Res Brain Res Protoc. 1997;1:211-6 pubmed
  15. Hackshaw K, Furlow Z, Chiu I. Cloning and characterization of a novel upstream untranslated exon of the mouse Fgf-1 gene. Gene. 1996;180:131-5 pubmed
    b>Fibroblast growth factor 1 (FGF-1 or aFGF), is the prototype member of the heparin-binding growth factors which are capable of angiogenesis in vivo...
  16. Hannon K, Kudla A, McAvoy M, Clase K, Olwin B. Differentially expressed fibroblast growth factors regulate skeletal muscle development through autocrine and paracrine mechanisms. J Cell Biol. 1996;132:1151-9 pubmed
    ..Thus, production of FGF-1 and FGF-2 by skeletal muscle cells may act as a paracrine and autocrine regulator of skeletal muscle development in vivo. ..
  17. Tsao P, Chen F, Izvolsky K, Walker J, Kukuruzinska M, LU J, et al. Gamma-secretase activation of notch signaling regulates the balance of proximal and distal fates in progenitor cells of the developing lung. J Biol Chem. 2008;283:29532-44 pubmed publisher
    ..Our data suggest a novel mechanism in which Notch and fibroblast growth factor signaling interact to control the proximal-distal pattern of forming airways in the mammalian lung. ..
  18. Popovici C, Roubin R, Coulier F, Birnbaum D. An evolutionary history of the FGF superfamily. Bioessays. 2005;27:849-57 pubmed
    ..A second expansion, which took place during euchordate evolution, is associated with genome duplications. It increased the number of members in the families. Subsequent losses reduced that number to the present-day figures. ..
  19. Miura T, Shiota K. Depletion of FGF acts as a lateral inhibitory factor in lung branching morphogenesis in vitro. Mech Dev. 2002;116:29-38 pubmed
    ..the lung epithelium exerted a lateral inhibitory effect on the neighbouring epithelium via depletion of fibroblast growth factor 1 (FGF1)...
  20. Sletten T, Kostas M, Bober J, Sorensen V, Yadollahi M, Olsnes S, et al. Nucleolin regulates phosphorylation and nuclear export of fibroblast growth factor 1 (FGF1). PLoS ONE. 2014;9:e90687 pubmed publisher
    Extracellular fibroblast growth factor 1 (FGF1) acts through cell surface tyrosine kinase receptors, but FGF1 can also act directly in the cell nucleus, as a result of nuclear import of endogenously produced, non-secreted FGF1 or by ..
  21. Madiai F, Hackshaw K. Expression of the mouse FGF-1 and FGF-1.A mRNAs during embryonic development and in the aging heart. Res Commun Mol Pathol Pharmacol. 2002;112:139-44 pubmed
    ..Moderate 1.A mRNA levels were revealed in head mesenchyme, paraxial mesoderm, in the embryonic inferior cunniculus, hyppocampus, and thymus. These results suggest a limited role of the Fgf-1.A mRNA variant during development. ..
  22. Labied S, Blacher S, Carmeliet P, Noel A, Frankenne F, Foidart J, et al. Transient reduction of placental angiogenesis in PAI-1-deficient mice. Physiol Genomics. 2011;43:188-98 pubmed publisher
    ..Altogether our data provide evidence for a transient impaired placental morphology in PAI-1-deficient mice that is then normalized, leading to normal embryonic development. ..
  23. Lodder E, Scicluna B, Beekman L, Arends D, Moerland P, Tanck M, et al. Integrative genomic approach identifies multiple genes involved in cardiac collagen deposition. Circ Cardiovasc Genet. 2014;7:790-8 pubmed publisher
    ..Of the 12 transcripts with an eQTLs in the Chr18-covariate region, only Fgf1 correlated with relative collagen amount...
  24. Miyatani S, Copeland N, Gilbert D, Jenkins N, Takeichi M. Genomic structure and chromosomal mapping of the mouse N-cadherin gene. Proc Natl Acad Sci U S A. 1992;89:8443-7 pubmed
    ..The E- and P-cadherin genes are tightly linked and located on chromosome 8 in this species. Thus, N-cadherin is unlinked to these other cadherin loci. ..
  25. Kirov A, Duarte M, Guay J, Karolak M, Yan C, Oxburgh L, et al. Transgenic expression of nonclassically secreted FGF suppresses kidney repair. PLoS ONE. 2012;7:e36485 pubmed publisher
    b>FGF1 is a signal peptide-less nonclassically released growth factor that is involved in angiogenesis, tissue repair, inflammation, and carcinogenesis. The effects of nonclassical FGF export in vivo are not sufficiently studied...
  26. Hsu Y, Liao W, Kao C, Chiu I. Regulation of FGF1 gene promoter through transcription factor RFX1. J Biol Chem. 2010;285:13885-95 pubmed publisher
    b>Fibroblast growth factor 1 (FGF1) has been suggested to have an important role in cell growth, proliferation, and neurogenesis...
  27. Mason I, Fuller Pace F, Smith R, Dickson C. FGF-7 (keratinocyte growth factor) expression during mouse development suggests roles in myogenesis, forebrain regionalisation and epithelial-mesenchymal interactions. Mech Dev. 1994;45:15-30 pubmed
    ..Our results suggest that FGF-7 is likely to have diverse roles during development. ..
  28. Graziani I, Bagala C, Duarte M, Soldi R, Kolev V, Tarantini F, et al. Release of FGF1 and p40 synaptotagmin 1 correlates with their membrane destabilizing ability. Biochem Biophys Res Commun. 2006;349:192-9 pubmed
    ..b>FGF1 and the other components of its secretory complex are signal peptide-less proteins...
  29. McClellan K, Vanderluit J, Julian L, Andrusiak M, Dugal Tessier D, Park D, et al. The p107/E2F pathway regulates fibroblast growth factor 2 responsiveness in neural precursor cells. Mol Cell Biol. 2009;29:4701-13 pubmed publisher
    ..By identifying novel roles for p107/E2F in regulating genes outside of the classical cell cycle machinery targets, we uncover a new mechanism whereby Rb/E2F mediates proliferation through regulating growth factor responsiveness. ..
  30. Ambrosetti D, Holmes G, Mansukhani A, Basilico C. Fibroblast growth factor signaling uses multiple mechanisms to inhibit Wnt-induced transcription in osteoblasts. Mol Cell Biol. 2008;28:4759-71 pubmed publisher
    ..Our results show that FGF antagonizes Wnt signaling by inhibiting Wnt-induced transcription and suggest that multiple mechanisms, including downregulation of TCFs and Wnt receptors, contribute to this effect. ..
  31. Pathak B, Gilbert D, Harrison C, Luetteke N, Chen X, Klagsbrun M, et al. Mouse chromosomal location of three EGF receptor ligands: amphiregulin (Areg), betacellulin (Btc), and heparin-binding EGF (Hegfl). Genomics. 1995;28:116-8 pubmed
    ..These results confirm and extend known relationships between mouse and human chromosomes, and they also provide new information regarding the evolution of this important gene family. ..
  32. Jaye M, Howk R, Burgess W, Ricca G, Chiu I, Ravera M, et al. Human endothelial cell growth factor: cloning, nucleotide sequence, and chromosome localization. Science. 1986;233:541-5 pubmed
    ..This property is shared by human interleukin-1, which is approximately 30 percent homologous to ECGF. ..
  33. Friocourt G, Kappeler C, Saillour Y, Fauchereau F, Rodriguez M, Bahi N, et al. Doublecortin interacts with the ubiquitin protease DFFRX, which associates with microtubules in neuronal processes. Mol Cell Neurosci. 2005;28:153-64 pubmed
    ..we show that DCX interacts with the ubiquitin-specific protease Drosophila fat facets related on X chromosome (DFFRX). This interaction was confirmed by targeted mutagenesis, colocalization, and immunoprecipitation studies...
  34. Huang X, Yu C, Jin C, Yang C, Xie R, Cao D, et al. Forced expression of hepatocyte-specific fibroblast growth factor 21 delays initiation of chemically induced hepatocarcinogenesis. Mol Carcinog. 2006;45:934-42 pubmed
    ..Here we showed that although widely expressed FGF1 and FGF2 are frequently upregulated in hepatocellular carcinoma (HCC), germline deletion of both FGF1 and FGF2 had ..
  35. Chen Z, Hasson T, Zhang D, Schwender B, Derfler B, Mooseker M, et al. Myosin-VIIb, a novel unconventional myosin, is a constituent of microvilli in transporting epithelia. Genomics. 2001;72:285-96 pubmed
    ..An antibody to myosin-VIIb labeled proximal tubule cells of the kidney and enterocytes of the intestine, specifically the distal tips of apical microvilli on these transporting epithelial cells. ..
  36. Lamothe B, Yamada M, Schaeper U, Birchmeier W, Lax I, Schlessinger J. The docking protein Gab1 is an essential component of an indirect mechanism for fibroblast growth factor stimulation of the phosphatidylinositol 3-kinase/Akt antiapoptotic pathway. Mol Cell Biol. 2004;24:5657-66 pubmed
    ..We have previously proposed that fibroblast growth factor 1 (FGF1) stimulation of tyrosine phosphorylation of Gab1 and recruitment of phosphatidylinositol (PI) 3-..
  37. Madiai F, Hackshaw K. Lack of FGF-1 overexpression during autoimmune nephritis in the kidneys of MRL lpr/lpr mice. Res Commun Mol Pathol Pharmacol. 1999;103:37-44 pubmed
    ..These results suggest that FGF-1 may not be involved in the pathogenesis of autoimmune nephritis in MRL lpr/lpr mice. ..
  38. Du W, Prochazka J, Prochazkova M, Klein O. Expression of FGFs during early mouse tongue development. Gene Expr Patterns. 2016;20:81-7 pubmed publisher
    ..Fgf10, Fgf13, Fgf15, Fgf16 and Fgf18 could all be detected with various intensities in the mesenchyme, whereas Fgf1 and Fgf2 were expressed in both the epithelium and the mesenchyme...
  39. Park W, Miranda B, Lebeche D, Hashimoto G, Cardoso W. FGF-10 is a chemotactic factor for distal epithelial buds during lung development. Dev Biol. 1998;201:125-34 pubmed
  40. Ito J, Nagayasu Y, Okumura Noji K, Lu R, Nishida T, Miura Y, et al. Mechanism for FGF-1 to regulate biogenesis of apoE-HDL in astrocytes. J Lipid Res. 2007;48:2020-7 pubmed
    ..The PI3K/Akt pathway upregulates secretion of apoE/apoE-HDL, the MEK/ERK pathway stimulates cholesterol biosynthesis, and an unknown pathway enhances apoE transcription. ..
  41. Zaret K. Liver specification and early morphogenesis. Mech Dev. 2000;92:83-8 pubmed
    ..The initial stages of hepatogenesis are therefore beginning to be understood, and serve as a paradigm for the development of other tissues from the endoderm. ..
  42. Dangond F, Foerznler D, Weremowicz S, Morton C, Beier D, Gullans S. Cloning and expression of a murine histone deacetylase 3 (mHdac3) cDNA and mapping to a region of conserved synteny between murine chromosome 18 and human chromosome 5. Mol Cell Biol Res Commun. 1999;2:91-6 pubmed
    ..3-q32 telomeric to the cytokine gene cluster. Transfection of mHdac3 into HeLa cells led to accumulation in G2/M. Our results suggest a cell cycle function for murine Hdac3, reflecting the complex regulatory roles of this gene family. ..
  43. Oka M, Rodic N, Graddy J, Chang L, Terada N. CpG sites preferentially methylated by Dnmt3a in vivo. J Biol Chem. 2006;281:9901-8 pubmed
    ..Selective methylation by a specific member of Dnmt3 may therefore play a role in the orchestration of gene expression during embryonic development. ..
  44. Luo Y, Ye S, Kan M, McKeehan W. Control of fibroblast growth factor (FGF) 7- and FGF1-induced mitogenesis and downstream signaling by distinct heparin octasaccharide motifs. J Biol Chem. 2006;281:21052-61 pubmed
    ..It failed to support FGF1 signaling in both HS-deficient mouse keratinocytes and 3T3 fibroblasts...
  45. Phelps M, Stuelsatz P, Yablonka Reuveni Z. Expression profile and overexpression outcome indicate a role for βKlotho in skeletal muscle fibro/adipogenesis. FEBS J. 2016;283:1653-68 pubmed publisher
  46. Scheraga R, Thompson C, Tulapurkar M, Nagarsekar A, Cowan M, Potla R, et al. Activation of heat shock response augments fibroblast growth factor-1 expression in wounded lung epithelium. Am J Physiol Lung Cell Mol Physiol. 2016;311:L941-L955 pubmed publisher
    ..Microarray, qRT-PCR, and immunoblotting showed fibroblast growth factor 1 (FGF1) to be synergistically induced by HS and wounding...
  47. Yamamoto H, Yun E, Gerber H, Ferrara N, Whitsett J, Vu T. Epithelial-vascular cross talk mediated by VEGF-A and HGF signaling directs primary septae formation during distal lung morphogenesis. Dev Biol. 2007;308:44-53 pubmed
  48. Conte C, Ainaoui N, Delluc Clavieres A, Khoury M, Azar R, Pujol F, et al. Fibroblast growth factor 1 induced during myogenesis by a transcription-translation coupling mechanism. Nucleic Acids Res. 2009;37:5267-78 pubmed publisher
    b>Fibroblast growth factor 1 (FGF1) is involved in muscle development and regeneration. The FGF1 gene contains four tissue-specific promoters allowing synthesis of four transcripts with distinct leader regions...
  49. Zhan X, Hu X, Hampton B, Burgess W, Friesel R, Maciag T. Murine cortactin is phosphorylated in response to fibroblast growth factor-1 on tyrosine residues late in the G1 phase of the BALB/c 3T3 cell cycle. J Biol Chem. 1993;268:24427-31 pubmed
    ..Because the chicken cortactin gene was originally isolated as a substrate for v-Src, FGF-1 may influence the enzymatic activity of other cell-associated tyrosine kinases which utilize p80/p85 (cortactin) as a polypeptide substrate. ..
  50. Speer A, Al Alam D, Sala F, Ford H, Bellusci S, Grikscheit T. Fibroblast growth factor 10-fibroblast growth factor receptor 2b mediated signaling is not required for adult glandular stomach homeostasis. PLoS ONE. 2012;7:e49127 pubmed publisher
    ..adult glandular stomach expressed Fgf10, its receptors, Fgfr1b and Fgfr2b, and most of the other FGFR2b ligands (Fgf1, Fgf7, Fgf22) except for Fgf3 and Fgf20...
  51. Muenke M, Schell U. Fibroblast-growth-factor receptor mutations in human skeletal disorders. Trends Genet. 1995;11:308-13 pubmed
    ..Comparison of these specific mutations with the resulting phenotypes is now providing new insight into the role of these receptors in normal and abnormal bone development. ..
  52. Wesche J, Małecki J, Wiedłocha A, Skjerpen C, Claus P, Olsnes S. FGF-1 and FGF-2 require the cytosolic chaperone Hsp90 for translocation into the cytosol and the cell nucleus. J Biol Chem. 2006;281:11405-12 pubmed
    Similarly to many protein toxins, the growth factors fibroblast growth factor 1 (FGF-1) and FGF-2 translocate from endosomes into the cytosol...
  53. Lin W, Xiang L, Shi H, Zhang J, Jiang L, Cai P, et al. Fibroblast growth factors stimulate hair growth through β-catenin and Shh expression in C57BL/6 mice. Biomed Res Int. 2015;2015:730139 pubmed publisher
    ..promoting activities of three approved growth factor drugs, fibroblast growth factor 10 (FGF-10), acidic fibroblast growth factor (FGF-1), and basic fibroblast growth factor (FGF-2), and the mechanism of action...
  54. Madiai F, Hackshaw K, Chiu I. Cloning and characterization of the mouse Fgf-1 gene. Gene. 1996;179:231-6 pubmed
    b>Fibroblast growth factor 1 (FGF-1 or aFGF), is a mitogen for a variety of mesoderm- and neuroectoderm-derived cells, as well as an angiogenic factor in vivo...
  55. Antoine M, Reimers K, Wirz W, Gressner A, Muller R, Kiefer P. Fibroblast growth factor 3, a protein with a dual subcellular fate, is interacting with human ribosomal protein S2. Biochem Biophys Res Commun. 2005;338:1248-55 pubmed
    ..Transient co-expression of rpS2 and nuclear FGF3 resulted in a reduced nucleolar localization of the FGF. These findings suggest that the nuclear form of FGF3 inhibits cell proliferation by interfering with ribosomal biogenesis. ..
  56. Luongo C, Gould K, Su L, Kinzler K, Vogelstein B, Dietrich W, et al. Mapping of multiple intestinal neoplasia (Min) to proximal chromosome 18 of the mouse. Genomics. 1993;15:3-8 pubmed
  57. Gorbea C, Marchand P, Jiang W, Copeland N, Gilbert D, Jenkins N, et al. Cloning, expression, and chromosomal localization of the mouse meprin beta subunit. J Biol Chem. 1993;268:21035-43 pubmed
  58. Cam Y, Neumann M, Oliver L, Raulais D, Janet T, Ruch J. Immunolocalization of acidic and basic fibroblast growth factors during mouse odontogenesis. Int J Dev Biol. 1992;36:381-9 pubmed
    Acidic and basic fibroblast growth factors (aFGF and bFGF), are both known to bind to extracellular matrix components, particularly proteoheparin sulfates, and to regulate in vitro proliferation, differentiation and morphology of cells of ..
  59. McAndrew P, Frostholm A, Evans J, Zdilar D, Goldowitz D, Chiu I, et al. Novel receptor protein tyrosine phosphatase (RPTPrho) and acidic fibroblast growth factor (FGF-1) transcripts delineate a rostrocaudal boundary in the granule cell layer of the murine cerebellar cortex. J Comp Neurol. 1998;391:444-55 pubmed
    ..b>Acidic fibroblast growth factor (FGF-1) mRNA follows a similar cerebellar expression pattern...
  60. Sims J, Williams D, Morrissey P, Garka K, Foxworthe D, Price V, et al. Molecular cloning and biological characterization of a novel murine lymphoid growth factor. J Exp Med. 2000;192:671-80 pubmed
    ..TSLP had comitogenic activity for fetal thymocytes, but was not as potent as interleukin 7 in lobe submersion cultures. Injection of TSLP into neonatal mice induced the expansion of B220(+)BP-1(+) pre-B cells. ..
  61. Pickles J. The expression of fibroblast growth factors and their receptors in the embryonic and neonatal mouse inner ear. Hear Res. 2001;155:54-62 pubmed
    ..The expression of the b and c variants of the FGF receptors, together with the expression of the ligands FGF1, FGF2, FGF3, FGF7, FGF8b and FGF8c, was determined by quantitative reverse transcription-polymerase chain reaction ..
  62. Pirou C, Montazer Torbati F, Jah N, Delmas E, Lasbleiz C, Mignotte B, et al. FGF1 protects neuroblastoma SH-SY5Y cells from p53-dependent apoptosis through an intracrine pathway regulated by FGF1 phosphorylation. Cell Death Dis. 2017;8:e3023 pubmed publisher
    ..As we previously showed that fibroblast growth factor 1 (FGF1) inhibited p53-dependent apoptosis in neuron-like PC12 cells, we initiated the study of the ..
  63. Mohan H, Friese A, Albrecht S, Krumbholz M, Elliott C, Arthur A, et al. Transcript profiling of different types of multiple sclerosis lesions yields FGF1 as a promoter of remyelination. Acta Neuropathol Commun. 2014;2:168 pubmed publisher
    ..Two MS tissue blocks comprised lesions with adjacent de- and remyelinated areas and FGF1 expression was higher in the remyelinated rim compared to the demyelinated lesion core...
  64. Wright T, Hatch E, Karabagli H, Karabagli P, Schoenwolf G, Mansour S. Expression of mouse fibroblast growth factor and fibroblast growth factor receptor genes during early inner ear development. Dev Dyn. 2003;228:267-72 pubmed
    ..Fgf16 was expressed in the posterior otic cup and vesicle, suggesting roles in otic cell fate decisions and/or axis formation. ..
  65. Fujimoto M, Izu H, Seki K, Fukuda K, Nishida T, Yamada S, et al. HSF4 is required for normal cell growth and differentiation during mouse lens development. EMBO J. 2004;23:4297-306 pubmed
  66. Graziani I, Doyle A, Sterling S, Kirov A, Tarantini F, Landriscina M, et al. Protein folding does not prevent the nonclassical export of FGF1 and S100A13. Biochem Biophys Res Commun. 2009;381:350-4 pubmed publisher
    ..is included in this group of polypeptides, as well as S100A13 that is a small calcium-binding protein critical for FGF1 export. Classically secreted proteins are transported into ER in their unfolded states...
  67. Hsu D, Donohue P, Alberts G, Winkles J. Fibroblast growth factor-1 induces phosphofructokinase, fatty acid synthase and Ca(2+)-ATPase mRNA expression in NIH 3T3 cells. Biochem Biophys Res Commun. 1993;197:1483-91 pubmed
    ..These results indicate that enhanced expression of the PFK, FAS and SERCA2 proteins may be important for FGF-1-stimulated cell proliferation. ..
  68. Smith L, Gross J, Morest D. Fibroblast growth factors (FGFs) in the cochlear nucleus of the adult mouse following acoustic overstimulation. Hear Res. 2002;169:1-12 pubmed
    ..Not limited to regions of cochlear nerve fiber and inner hair cell loss, the changes in FGFs may represent a reaction to outer hair cell damage which spreads broadly across the central pathways. ..
  69. Kim S, Kim S, Kwon C, Kim Y. Differential effect of FGF and PDGF on cell proliferation and migration in osteoblastic cells. Growth Factors. 2007;25:77-86 pubmed
    ..These data are of importance in understanding the roles of these growth factors in osteoblastic cell proliferation and migration. ..
  70. Sugaya N, Habuchi H, Nagai N, Ashikari Hada S, Kimata K. 6-O-sulfation of heparan sulfate differentially regulates various fibroblast growth factor-dependent signalings in culture. J Biol Chem. 2008;283:10366-76 pubmed publisher
    ..5-fold higher than that of HS from WT-MEFs. Thus, 6-O-sulfate in HS may regulate the signalings of some of HB-GFs, including FGFs, by inducing different interactions between ligands and their receptors. ..
  71. Suh J, Jonker J, Ahmadian M, Goetz R, Lackey D, Osborn O, et al. Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer. Nature. 2014;513:436-9 pubmed publisher
    Fibroblast growth factor 1 (FGF1) is an autocrine/paracrine regulator whose binding to heparan sulphate proteoglycans effectively precludes its circulation...
  72. Vidrich A, Buzan J, Ilo C, Bradley L, Skaar K, Cohn S. Fibroblast growth factor receptor-3 is expressed in undifferentiated intestinal epithelial cells during murine crypt morphogenesis. Dev Dyn. 2004;230:114-23 pubmed
    ..FGFR-3 IIIb was the dominant isoform expressed in both small intestinal and colonic crypts. Expression of FGF1, FGF2, and FGF9, known ligands of FGFR-3, paralleled patterns of FGFR-3 expression during gut development...
  73. Robinson M, Overbeek P, Verran D, Grizzle W, Stockard C, Friesel R, et al. Extracellular FGF-1 acts as a lens differentiation factor in transgenic mice. Development. 1995;121:505-14 pubmed
    ..The transgenic induction of differentiation confirms that normal lens morphology reflects an asymmetric distribution of inductive factors within the eye. ..
  74. Jacquemin E, Halley C, Alterio J, Laurent M, Courtois Y, Jeanny J. Localization of acidic fibroblast growth factor (aFGF) mRNA in mouse and bovine retina by in situ hybridization. Neurosci Lett. 1990;116:23-8 pubmed
    b>Acidic fibroblast growth factor (aFGF) mRNA has been detected in adult mouse or bovine retina by in situ hybridization with bovine aFGF cDNA clones...
  75. Soldi R, Mandinova A, Venkataraman K, Hla T, Vadas M, Pitson S, et al. Sphingosine kinase 1 is a critical component of the copper-dependent FGF1 export pathway. Exp Cell Res. 2007;313:3308-18 pubmed
    ..Because copper-dependent non-classical stress-induced release of FGF1 also regulates angiogenesis, we questioned whether sphingosine kinase 1 is involved in the FGF1 release pathway...
  76. Donohue P, Alberts G, Guo Y, Winkles J. Identification by targeted differential display of an immediate early gene encoding a putative serine/threonine kinase. J Biol Chem. 1995;270:10351-7 pubmed
    ..These results indicate that Fnk may be a transiently expressed protein kinase involved in the early signaling events required for growth factor-stimulated cell cycle progression. ..
  77. Huang Z, Tan Y, Gu J, Liu Y, Song L, Niu J, et al. Uncoupling the Mitogenic and Metabolic Functions of FGF1 by Tuning FGF1-FGF Receptor Dimer Stability. Cell Rep. 2017;20:1717-1728 pubmed publisher
    The recent discovery of metabolic roles for fibroblast growth factor 1 (FGF1) in glucose homeostasis has expanded the functions of this classically known mitogen...
  78. Ho U, Wainwright B. Patched1 patterns Fibroblast growth factor 10 and Forkhead box F1 expression during pulmonary branch formation. Mech Dev. 2017;147:37-48 pubmed publisher
  79. Jaskoll T, Zhou Y, Chai Y, Makarenkova H, Collinson J, West J, et al. Embryonic submandibular gland morphogenesis: stage-specific protein localization of FGFs, BMPs, Pax6 and Pax9 in normal mice and abnormal SMG phenotypes in FgfR2-IIIc(+/Delta), BMP7(-/-) and Pax6(-/-) mice. Cells Tissues Organs. 2002;170:83-98 pubmed
    ..Finally, our observations of abnormal SMGs in BMP7(-/-) and Pax6(-/-) indicate that both BMP7 and Pax6 play important roles during embryonic SMG branching morphogenesis. ..
  80. Donohue P, Alberts G, Hampton B, Winkles J. A delayed-early gene activated by fibroblast growth factor-1 encodes a protein related to aldose reductase. J Biol Chem. 1994;269:8604-9 pubmed
    ..These results raise the possibility that aldose reductase-related proteins may play a role in FGF-1- and FGF-2-stimulated mitogenesis. ..