Fgf1

Summary

Gene Symbol: Fgf1
Description: fibroblast growth factor 1
Alias: Dffrx, Fam, Fgf-1, Fgfa, HBGF-1, aFGF, acidic fibroblast growth factor, fibroblast growth factor 1 (acidic), heparin-binding growth factor 1
Species: mouse

Top Publications

  1. ncbi Interspersed repetitive element polymerase chain reaction product mapping using a mouse interspecific backcross
    R D Cox
    Genome Analysis Laboratory, Imperial Cancer Research Fund Laboratories, London, United Kingdom
    Genomics 10:375-84. 1991
  2. ncbi Functional evolutionary history of the mouse Fgf gene family
    Nobuyuki Itoh
    Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Sakyo, Kyoto, Japan
    Dev Dyn 237:18-27. 2008
  3. pmc Thrombin induces rapid PAR1-mediated non-classical FGF1 release
    Maria Duarte
    Maine Medical Center Research Institute, 81 Research Drive, Scarborough, ME 04074, USA
    Biochem Biophys Res Commun 350:604-9. 2006
  4. pmc Role of fibroblast growth factor type 1 and 2 in carbon tetrachloride-induced hepatic injury and fibrogenesis
    Chundong Yu
    Department of Biochemistry and Biophysics, Texas A and M University, and the Center for Cancer Biology and Nutrition, Institute of Biosciences and Technology, Texas A and M University System Health Science Center, Houston, Texas 77030, USA
    Am J Pathol 163:1653-62. 2003
  5. pmc Compensation by fibroblast growth factor 1 (FGF1) does not account for the mild phenotypic defects observed in FGF2 null mice
    D L Miller
    Department of Microbiology, New York University School of Medicine, New York, New York 10016, USA
    Mol Cell Biol 20:2260-8. 2000
  6. ncbi Characterization of the entire transcription unit of the mouse fibroblast growth factor 1 (FGF-1) gene. Tissue-specific expression of the FGF-1.A mRNA
    F Madiai
    Department of Internal Medicine and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 274:11937-44. 1999
  7. pmc Internal ribosome entry site structural motifs conserved among mammalian fibroblast growth factor 1 alternatively spliced mRNAs
    Yvan Martineau
    Institut National de la Santé et de la Recherche Médicale U589, Hormones, Facteurs de Croissance et Physiopathologie Vasculaire, Institut Louis Bugnard, IFR31, CHU Rangueil, 31059 Toulouse cedex 09, France
    Mol Cell Biol 24:7622-35. 2004
  8. ncbi Tumorigenesis in transgenic mice in which the SV40 T antigen is driven by the brain-specific FGF1 promoter
    I M Chiu
    Department of Internal Medicine, The Ohio State University, Columbus, Ohio, OH 43210, USA
    Oncogene 19:6229-39. 2000
  9. ncbi Developmental regulation of neural response to FGF-1 and FGF-2 by heparan sulfate proteoglycan
    V Nurcombe
    Department of Anatomy and Cell Biology, University of Melbourne, Parkville, Australia
    Science 260:103-6. 1993
  10. ncbi Characterization of the 1B promoter of fibroblast growth factor 1 and its expression in the adult and developing mouse brain
    K Y Alam
    Department of Internal Medicine, College of Medicine, The Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 271:30263-71. 1996

Research Grants

Scientific Experts

  • Xu Guang Nie
  • I M Chiu
  • J E Sims
  • K S Zaret
  • M P Hoffman
  • Antoni Wiedłocha
  • James O Pickles
  • Yong K Kim
  • Camille Allera-Moreau
  • Nobuyuki Itoh
  • W V Cardoso
  • F Dangond
  • TINA F JASKOLL
  • Jørgen Wesche
  • T Miura
  • Irene Graziani
  • F Madiai
  • Malgorzata Zakrzewska
  • K V Hackshaw
  • Igor Prudovsky
  • Maria Duarte
  • Yvan Martineau
  • Xinqiang Huang
  • Johan W Jonker
  • Marie Paschaki
  • Claudia M Garcia
  • Chundong Yu
  • Katsuya Okamoto
  • Elisabetta Catalani
  • Caroline Conte
  • Kelly A McClellan
  • Sjur Olsnes
  • Antoni Wiedlocha
  • Vigdis Sørensen
  • Noriko Sugaya
  • Andrew Doyle
  • Francesca Tarantini
  • David Neivandt
  • Su Jin Kim
  • Minke van Tuyl
  • Marios P Stavridis
  • Jin Ichi Ito
  • Anne Catherine Prats
  • Raffaella Soldi
  • Thomas Maciag
  • Vihren Kolev
  • Amanda E Serls
  • Alexandra A Blak
  • Wallace L McKeehan
  • Fen Wang
  • Chengliu Jin
  • Mitsuaki Fujimoto
  • Alda Vidrich
  • Reema Jasuja
  • C Bagala
  • Tracy J Wright
  • Ruth Simon
  • Lee Smith
  • Mohammad K Hajihosseini
  • Arnaud André Mailleux
  • Ruth T Yu
  • Jamie Whyte
  • Yun Qiang Yin
  • M Bachler
  • Richard H Finnell
  • Jae Myoung Suh
  • Colin T Phillips
  • Rebecca Lee Yean Wong
  • Pingping Li
  • Pascal Dolle
  • Jerrold M Olefsky
  • Song Chang Lin
  • Mingxiao He
  • Michael Downes
  • Y Zhang
  • Robert R Henry
  • Henry Juguilon
  • Annette R Atkins
  • Karen Niederreither
  • Ronald M Evans
  • Maryam Ahmadian
  • David C Beebe
  • Ying Liu
  • Bhavani P Madakashira
  • Lisa Dattilo
  • Ramya Rajagopal
  • P J Donohue
  • Jie Huang
  • Michael L Robinson
  • M Nguyen

Detail Information

Publications78

  1. ncbi Interspersed repetitive element polymerase chain reaction product mapping using a mouse interspecific backcross
    R D Cox
    Genome Analysis Laboratory, Imperial Cancer Research Fund Laboratories, London, United Kingdom
    Genomics 10:375-84. 1991
    ..We anticipate that many more markers remain to be characterized in this valuable new source of polymorphism...
  2. ncbi Functional evolutionary history of the mouse Fgf gene family
    Nobuyuki Itoh
    Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Sakyo, Kyoto, Japan
    Dev Dyn 237:18-27. 2008
    ..subfamily (iFGFs), the hormone-like Fgf15/21/23 subfamily (hFGFs), and the canonical Fgf subfamilies, including Fgf1/2/5, Fgf3/4/6, Fgf7/10/22, Fgf8/17/18, and Fgf9/16/20. However, all Fgfs are evolutionarily related...
  3. pmc Thrombin induces rapid PAR1-mediated non-classical FGF1 release
    Maria Duarte
    Maine Medical Center Research Institute, 81 Research Drive, Scarborough, ME 04074, USA
    Biochem Biophys Res Commun 350:604-9. 2006
    ..thrombin rapidly stimulated expression and release of the pro-angiogenic polypeptide fibroblast growth factor 1 (FGF1)...
  4. pmc Role of fibroblast growth factor type 1 and 2 in carbon tetrachloride-induced hepatic injury and fibrogenesis
    Chundong Yu
    Department of Biochemistry and Biophysics, Texas A and M University, and the Center for Cancer Biology and Nutrition, Institute of Biosciences and Technology, Texas A and M University System Health Science Center, Houston, Texas 77030, USA
    Am J Pathol 163:1653-62. 2003
    ..the potential role of all 23 FGF polypeptides in the liver is still unclear, the most widely studied prototypes, FGF1 and FGF2, are present and have been implicated in liver cell growth and function in vitro...
  5. pmc Compensation by fibroblast growth factor 1 (FGF1) does not account for the mild phenotypic defects observed in FGF2 null mice
    D L Miller
    Department of Microbiology, New York University School of Medicine, New York, New York 10016, USA
    Mol Cell Biol 20:2260-8. 2000
    Fibroblast growth factor 1 (FGF1) and FGF2, the prototypic members of the FGF family of growth factors, have been implicated in a variety of physiological and pathological processes...
  6. ncbi Characterization of the entire transcription unit of the mouse fibroblast growth factor 1 (FGF-1) gene. Tissue-specific expression of the FGF-1.A mRNA
    F Madiai
    Department of Internal Medicine and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 274:11937-44. 1999
    ..A mRNA. Finally, via both RNase protection analysis and 5'-rapid amplification of cDNA ends, we determined the transcription start site of the FGF-1.A mRNA...
  7. pmc Internal ribosome entry site structural motifs conserved among mammalian fibroblast growth factor 1 alternatively spliced mRNAs
    Yvan Martineau
    Institut National de la Santé et de la Recherche Médicale U589, Hormones, Facteurs de Croissance et Physiopathologie Vasculaire, Institut Louis Bugnard, IFR31, CHU Rangueil, 31059 Toulouse cedex 09, France
    Mol Cell Biol 24:7622-35. 2004
    ..These data favor an important role of IRESs in the control of FGF-1 expression and provide a new IRES structural motif that could help IRES prediction in 5' UTR databases...
  8. ncbi Tumorigenesis in transgenic mice in which the SV40 T antigen is driven by the brain-specific FGF1 promoter
    I M Chiu
    Department of Internal Medicine, The Ohio State University, Columbus, Ohio, OH 43210, USA
    Oncogene 19:6229-39. 2000
    ..Previously, we have shown that the human FGF1 gene contains four distinct tissue-specific promoters...
  9. ncbi Developmental regulation of neural response to FGF-1 and FGF-2 by heparan sulfate proteoglycan
    V Nurcombe
    Department of Anatomy and Cell Biology, University of Melbourne, Parkville, Australia
    Science 260:103-6. 1993
    ..Thus, a single species of HSPG undergoes a rapid, tightly controlled change in growth factor-binding specificity concomitant with the temporal expression of the FGFs...
  10. ncbi Characterization of the 1B promoter of fibroblast growth factor 1 and its expression in the adult and developing mouse brain
    K Y Alam
    Department of Internal Medicine, College of Medicine, The Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 271:30263-71. 1996
    ..The relatively late developmental expression suggests a role for FGF-1 in neuronal maturation, rather than in neurogenesis...
  11. pmc Phosphorylation of fibroblast growth factor (FGF) receptor 1 at Ser777 by p38 mitogen-activated protein kinase regulates translocation of exogenous FGF1 to the cytosol and nucleus
    Vigdis Sørensen
    Centre for Cancer Biomedicine, Faculty Division Norwegian Radium Hospital, University of Oslo, Oslo, Norway
    Mol Cell Biol 28:4129-41. 2008
    Exogenous fibroblast growth factor 1 (FGF1) signals through activation of transmembrane FGF receptors (FGFRs) but may also regulate cellular processes after translocation to the cytosol and nucleus of target cells...
  12. pmc Phosphorylation-regulated nucleocytoplasmic trafficking of internalized fibroblast growth factor-1
    Antoni Wiedłocha
    Institute for Cancer Research, The Norwegian Radium Hospital, 0310 Oslo, Norway
    Mol Biol Cell 16:794-810. 2005
    ..The nucleocytoplasmic trafficking of the phosphorylated growth factor is likely to play a role in the activity of internalized FGF-1...
  13. ncbi A molecular genetic linkage map of mouse chromosome 18 reveals extensive linkage conservation with human chromosomes 5 and 18
    M J Justice
    Mammalian Genetics Laboratory, ABL Basic Research Program, NCI Frederick Cancer Research and Development Center, Maryland 21702
    Genomics 13:1281-8. 1992
    ..The Apc, Camk2a, D18Fcr1, D18Fcr2, D18Leh1, D18Leh2, Dcc, Emb-rs3, Fgfa, Fim-2/Csfmr, Gnal, Grl-1, Grp, Hk-1rs1, Ii, Kns, Lmnb, Mbp, Mcc, Mtv-38, Palb, Pdgfrb, and Tpl-2 genes were mapped ..
  14. pmc Retinoic acid-dependent signaling pathways and lineage events in the developing mouse spinal cord
    Marie Paschaki
    Development and Stem Cells Department, Centre National de la Recherche Scientifique UMR 7104, Institut National de la Santé et de la Recherche Médicale U 964, Universite de Strasbourg, Illkirch Strasbourg, France
    PLoS ONE 7:e32447. 2012
    ....
  15. pmc A PPARγ-FGF1 axis is required for adaptive adipose remodelling and metabolic homeostasis
    Johan W Jonker
    Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Nature 485:391-4. 2012
    ..Here we identify fibroblast growth factor 1 (FGF1) as a critical transducer in this process in mice, and link its regulation to the nuclear receptor PPARγ (..
  16. doi Evidence of interlobular repulsion during branching morphogenesis in mouse salivary glands
    Katsuya Okamoto
    Department of Biology, Graduate School of Science, Chiba University, Chiba 263 8522, Japan
    Dev Dyn 239:2208-18. 2010
    ..In contrast, strong repulsion was observed among the epithelia cultured with fibroblast growth factor 1 (FGF1), which exhibited less branching and moved away from the center...
  17. ncbi Fibroblast growth factor receptor-3 is expressed in undifferentiated intestinal epithelial cells during murine crypt morphogenesis
    Alda Vidrich
    Digestive Health Center of Excellence, University of Virginia, Charlottesville, Virginia 22908, USA
    Dev Dyn 230:114-23. 2004
    ..FGFR-3 IIIb was the dominant isoform expressed in both small intestinal and colonic crypts. Expression of FGF1, FGF2, and FGF9, known ligands of FGFR-3, paralleled patterns of FGFR-3 expression during gut development...
  18. pmc The function of FGF signaling in the lens placode
    Claudia M Garcia
    Department of Ophthalmology and Visual Sciences, Washington University, St Louis, MO 63110, USA
    Dev Biol 351:176-85. 2011
    ..Since the expression of proteins required for lens formation was not altered in the knockout placode cells, we can conclude that FGF signaling from the optic vesicle is not required for lens induction...
  19. pmc Postnatal lethality in mice lacking the Sax2 homeobox gene homologous to Drosophila S59/slouch: evidence for positive and negative autoregulation
    Ruth Simon
    Brookdale Center for Developmental and Molecular Biology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029 6574, USA
    Mol Cell Biol 23:9046-60. 2003
    ..Intriguingly, our studies also demonstrated a striking autoregulation of the Sax2 gene in both positive- and negative-feedback mechanisms depending on the specific cell type expressing Sax2...
  20. ncbi The alternative translation of synaptotagmin 1 mediates the non-classical release of FGF1
    C Bagala
    Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough, ME 04074, USA
    Biochem Biophys Res Commun 310:1041-7. 2003
    ..protein, p65 synaptotagmin (Syt) 1, is essential for the non-classical export of the signal peptide-less structure, FGF1, it was not possible to identify a specific intracellular protease responsible for the processing of p65 Syt1...
  21. ncbi Expression of mouse fibroblast growth factor and fibroblast growth factor receptor genes during early inner ear development
    Tracy J Wright
    Department of Human Genetics, University of Utah, Salt Lake City, Utah 84112 5330, USA
    Dev Dyn 228:267-72. 2003
    ..Fgf16 was expressed in the posterior otic cup and vesicle, suggesting roles in otic cell fate decisions and/or axis formation...
  22. ncbi A delayed-early gene activated by fibroblast growth factor-1 encodes a protein related to aldose reductase
    P J Donohue
    Department of Molecular Biology, Holland Laboratory, American Red Cross, Rockville, Maryland 20855
    J Biol Chem 269:8604-9. 1994
    ..These results raise the possibility that aldose reductase-related proteins may play a role in FGF-1- and FGF-2-stimulated mitogenesis...
  23. pmc Increased protein stability of FGF1 can compensate for its reduced affinity for heparin
    Malgorzata Zakrzewska
    Centre for Cancer Biomedicine, University of Oslo, and Department of Biochemistry, Institute for Cancer Research, Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway
    J Biol Chem 284:25388-403. 2009
    Human FGF1 (fibroblast growth factor 1) is a powerful signaling molecule with a short half-life in vivo and a denaturation temperature close to physiological...
  24. ncbi Gene expression profiles of mouse submandibular gland development: FGFR1 regulates branching morphogenesis in vitro through BMP- and FGF-dependent mechanisms
    Matthew P Hoffman
    Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, MSC 4370, Bethesda, MD 20892 4370, USA
    Development 129:5767-78. 2002
    ..FGFR1 signaling regulates Fgfr1, Fgf1, Fgf3 and Bmp7 expression and indirectly regulates Fgf7, Fgf10 and Bmp4...
  25. ncbi Depletion of FGF acts as a lateral inhibitory factor in lung branching morphogenesis in vitro
    Takashi Miura
    Department of Anatomy and Developmental Biology, Kyoto University Graduate School of Medicine, Japan
    Mech Dev 116:29-38. 2002
    ..exerted a lateral inhibitory effect on the neighbouring epithelium via depletion of fibroblast growth factor 1 (FGF1). Contrary to previous suggestions, bone morphogenetic protein 4 could not substitute for the inhibitory effect...
  26. ncbi Fibroblast growth factors (FGFs) in the cochlear nucleus of the adult mouse following acoustic overstimulation
    Lee Smith
    Department of Neuroscience, The University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 3401, USA
    Hear Res 169:1-12. 2002
    ..Not limited to regions of cochlear nerve fiber and inner hair cell loss, the changes in FGFs may represent a reaction to outer hair cell damage which spreads broadly across the central pathways...
  27. ncbi Cell-surface heparan sulfate proteoglycans potentiate chordin antagonism of bone morphogenetic protein signaling and are necessary for cellular uptake of chordin
    Reema Jasuja
    Program in Molecular and Cellular Pharmacology, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Biol Chem 279:51289-97. 2004
    ..These data and others regarding Chordin diffusion have implications for the paradigm of how Chordin is thought to regulate BMP signaling in the extracellular space and how gradients of BMP signaling are formed...
  28. pmc HSF4 is required for normal cell growth and differentiation during mouse lens development
    Mitsuaki Fujimoto
    Department of Biochemistry and Molecular Biology, Yamaguchi University School of Medicine, Minami Kogushi 1 1 1, Ube 755 8505, Japan
    EMBO J 23:4297-306. 2004
    ....
  29. ncbi A discrete period of FGF-induced Erk1/2 signalling is required for vertebrate neural specification
    Marios P Stavridis
    Division of Cell and Developmental Biology, University of Dundee, Dow Street, Dundee DD1 5EH, UK
    Development 134:2889-94. 2007
    ....
  30. doi 6-O-sulfation of heparan sulfate differentially regulates various fibroblast growth factor-dependent signalings in culture
    Noriko Sugaya
    Institute for Molecular Science of Medicine, Aichi Medical University, Nagakute, Aichi 480 1195, Japan
    J Biol Chem 283:10366-76. 2008
    ..5-fold higher than that of HS from WT-MEFs. Thus, 6-O-sulfate in HS may regulate the signalings of some of HB-GFs, including FGFs, by inducing different interactions between ligands and their receptors...
  31. pmc Release of FGF1 and p40 synaptotagmin 1 correlates with their membrane destabilizing ability
    Irene Graziani
    Center for Molecular Medicine, Maine Medical Center Research Institute, 81 Research Drive, Scarborough, ME 04074, USA
    Biochem Biophys Res Commun 349:192-9. 2006
    ..b>FGF1 and the other components of its secretory complex are signal peptide-less proteins...
  32. ncbi Differential effect of FGF and PDGF on cell proliferation and migration in osteoblastic cells
    Su Jin Kim
    Department of Pediatrics, College of Medicine, Pusan National University, Pusan 602 739, South Korea
    Growth Factors 25:77-86. 2007
    ..These data are of importance in understanding the roles of these growth factors in osteoblastic cell proliferation and migration...
  33. ncbi Mechanism for FGF-1 to regulate biogenesis of apoE-HDL in astrocytes
    Jin Ichi Ito
    Biochemistry, Nagoya City University Graduate School of Medical Sciences, Nagoya 467 8601, Japan
    J Lipid Res 48:2020-7. 2007
    ..The PI3K/Akt pathway upregulates secretion of apoE/apoE-HDL, the MEK/ERK pathway stimulates cholesterol biosynthesis, and an unknown pathway enhances apoE transcription...
  34. ncbi Angiogenic factors stimulate tubular branching morphogenesis of sonic hedgehog-deficient lungs
    Minke van Tuyl
    Canadian Institutes of Health Research Group in Lung Development, Hospital for Sick Children Research Institute, University of Toronto, 555 University Avenue, Toronto, Ontario, Canada
    Dev Biol 303:514-26. 2007
    ..Stimulation of vascularization with angiogenic factors such as Fgf2 and Ang1 partially restored tubular growth and branching in Shh-deficient lungs, suggesting that vascularization is required for branching morphogenesis...
  35. ncbi Developmentally regulated expression of MSX1, MSX2 and Fgfs in the developing mouse cranial base
    Xuguang Nie
    Department of Biomedicine, University of Bergen, Bergen, Norway
    Angle Orthod 76:990-5. 2006
    ..To examine the expression pattern of the Fgf and Msx genes in cranial base development...
  36. pmc Protein folding does not prevent the nonclassical export of FGF1 and S100A13
    Irene Graziani
    Maine Medical Center Research Institute, Scarborough, 81 Research Dr, Scarborough, ME 04074, USA
    Biochem Biophys Res Commun 381:350-4. 2009
    ..is included in this group of polypeptides, as well as S100A13 that is a small calcium-binding protein critical for FGF1 export. Classically secreted proteins are transported into ER in their unfolded states...
  37. pmc Fibroblast growth factor 1 induced during myogenesis by a transcription-translation coupling mechanism
    Caroline Conte
    INSERM, U858 and Institut de Médecine Moléculaire de Rangueil, Universite de Toulouse, UPS, IFR150, F 31432 Toulouse, France
    Nucleic Acids Res 37:5267-78. 2009
    Fibroblast growth factor 1 (FGF1) is involved in muscle development and regeneration. The FGF1 gene contains four tissue-specific promoters allowing synthesis of four transcripts with distinct leader regions...
  38. pmc The p107/E2F pathway regulates fibroblast growth factor 2 responsiveness in neural precursor cells
    Kelly A McClellan
    University of Ottawa, Department of Cellular and Molecular Medicine, Ontario, Canada
    Mol Cell Biol 29:4701-13. 2009
    ..By identifying novel roles for p107/E2F in regulating genes outside of the classical cell cycle machinery targets, we uncover a new mechanism whereby Rb/E2F mediates proliferation through regulating growth factor responsiveness...
  39. ncbi Forced expression of hepatocyte-specific fibroblast growth factor 21 delays initiation of chemically induced hepatocarcinogenesis
    Xinqiang Huang
    Center for Cancer Biology and Nutrition, Institute of Biosciences and Technology, Texas A and M University System Health Science Center, Houston, Texas 77030, USA
    Mol Carcinog 45:934-42. 2006
    ..Here we showed that although widely expressed FGF1 and FGF2 are frequently upregulated in hepatocellular carcinoma (HCC), germline deletion of both FGF1 and FGF2 had ..
  40. ncbi Expression of Fgf receptors 1, 2, and 3 in the developing mid- and hindbrain of the mouse
    Alexandra A Blak
    GSF National Research Center for Environment and Health, Institute of Developmental Genetics, Neuherberg, Germany
    Dev Dyn 233:1023-30. 2005
    ..Fgfr3 expression is in contact with the Fgf8 expression domain only in the rostroventral hindbrain. Based on these findings, we postulate a role for FGFR2 and FGFR3 in FGF signaling in the ventral midbrain and hindbrain...
  41. ncbi Different thresholds of fibroblast growth factors pattern the ventral foregut into liver and lung
    Amanda E Serls
    Department of Pathology, University of Colorado Health Sciences Center, The Children s Hospital, 1056 East 19th Avenue, Denver, CO 80218, USA
    Development 132:35-47. 2005
    ..Together, the findings suggest that a concentration threshold of FGFs emanating from the cardiac mesoderm are involved in patterning the foregut endoderm...
  42. ncbi Expression patterns of fibroblast growth factors-18 and -20 in mouse embryos is suggestive of novel roles in calvarial and limb development
    Mohammad K Hajihosseini
    School of Biosciences, The University of Birmingham, B15 2TT, UK
    Mech Dev 113:79-83. 2002
    ....
  43. ncbi Immunolocalization of acidic and basic fibroblast growth factors during mouse odontogenesis
    Y Cam
    Institut de Biologie Medicale, INSERM CJF 88 08, Universite Louis Pasteur, Faculte de Medecine, Strasbourg, France
    Int J Dev Biol 36:381-9. 1992
    Acidic and basic fibroblast growth factors (aFGF and bFGF), are both known to bind to extracellular matrix components, particularly proteoheparin sulfates, and to regulate in vitro proliferation, differentiation and morphology of cells of ..
  44. ncbi Cloning and characterization of the mouse Fgf-1 gene
    F Madiai
    Department of Internal Medicine, The Ohio State University, William H Davis Medical Research Center, Columbus 43210, USA
    Gene 179:231-6. 1996
    Fibroblast growth factor 1 (FGF-1 or aFGF), is a mitogen for a variety of mesoderm- and neuroectoderm-derived cells, as well as an angiogenic factor in vivo...
  45. ncbi Msx1 controls inductive signaling in mammalian tooth morphogenesis
    Y Chen
    Howard Hughes Medical Institute, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Development 122:3035-44. 1996
    ..We propose that Msx genes function repetitively during vertebrate organogenesis to permit inductive signaling to occur back and forth between tissue layers...
  46. ncbi Expression of the fibroblast growth factor family and their receptor family genes during mouse brain development
    K Ozawa
    Cell Biology Laboratory, National Institute of Bioscience and Human Technology, Ibaraki, Japan
    Brain Res Mol Brain Res 41:279-88. 1996
    ..e., proliferation and migration of neuronal progenitor cells, neuron and glia differentiation, neurite extensions, and synapse formations...
  47. ncbi Chromosomal localisation of genes coding for human and mouse liver cytosolic cysteine dioxygenase
    S Jeremiah
    Galton Laboratory, University College London, UK
    Ann Hum Genet 60:29-33. 1996
    ..Interspecific backcross mapping in the mouse indicated that Cdo, the mouse homologue of CDO, is situated in the central region of mouse chromosome 18 which shares a region of homology with human chromosome 5...
  48. ncbi FGF suppresses apoptosis and induces differentiation of fibre cells in the mouse lens
    R L Chow
    Skirball Institute for Biomolecular Medicine, New York University Medical Center, NY 10016, USA
    Development 121:4383-93. 1995
    ..These results show that lens fibre cells are dependent on FGF for their survival and differentiation, and demonstrate that growth factor deprivation in vivo can lead to apoptosis...
  49. ncbi Mapping of multiple intestinal neoplasia (Min) to proximal chromosome 18 of the mouse
    C Luongo
    McArdle Laboratory for Cancer Research, University of Wisconsin Madison 53706
    Genomics 15:3-8. 1993
    ....
  50. ncbi Induction of keratinocyte growth factor expression is reduced and delayed during wound healing in the genetically diabetic mouse
    S Werner
    Max Planck Institut fur Biochemie, Martinsried, Germany
    J Invest Dermatol 103:469-73. 1994
    ..Induction of acidic fibroblast growth factor (FGF) and basic FGF expression was earlier in diabetic mice than in normal mice, but by 3 d after ..
  51. ncbi Identification by targeted differential display of an immediate early gene encoding a putative serine/threonine kinase
    P J Donohue
    Department of Molecular Biology, Holland Laboratory, American Red Cross, Rockville, Maryland 20855, USA
    J Biol Chem 270:10351-7. 1995
    ..These results indicate that Fnk may be a transiently expressed protein kinase involved in the early signaling events required for growth factor-stimulated cell cycle progression...
  52. ncbi Murine cortactin is phosphorylated in response to fibroblast growth factor-1 on tyrosine residues late in the G1 phase of the BALB/c 3T3 cell cycle
    X Zhan
    Department of Molecular Biology, Holland Laboratory, American Red Cross, Rockville, Maryland 20855
    J Biol Chem 268:24427-31. 1993
    ..Because the chicken cortactin gene was originally isolated as a substrate for v-Src, FGF-1 may influence the enzymatic activity of other cell-associated tyrosine kinases which utilize p80/p85 (cortactin) as a polypeptide substrate...
  53. ncbi Fibroblast growth factor-1 induces phosphofructokinase, fatty acid synthase and Ca(2+)-ATPase mRNA expression in NIH 3T3 cells
    D K Hsu
    Department of Molecular Biology, Holland Laboratory, American Red Cross, Rockville, Maryland 20855
    Biochem Biophys Res Commun 197:1483-91. 1993
    ..These results indicate that enhanced expression of the PFK, FAS and SERCA2 proteins may be important for FGF-1-stimulated cell proliferation...
  54. ncbi Localization of acidic fibroblast growth factor (aFGF) mRNA in mouse and bovine retina by in situ hybridization
    E Jacquemin
    Unite de Recherches Gerontologiques, U 118 INSERM, Unité affiliée CNRS, Association Claude Bernard, Paris, France
    Neurosci Lett 116:23-8. 1990
    b>Acidic fibroblast growth factor (aFGF) mRNA has been detected in adult mouse or bovine retina by in situ hybridization with bovine aFGF cDNA clones...
  55. ncbi A multipoint genetic linkage map of mouse chromosome 18
    K R Johnson
    Jackson Laboratory, Bar Harbor, Maine 04609
    Genomics 13:1143-9. 1992
    ..3-Tpi-10-11.8-(Egr-1, Hmg17-rs9)-2.1-Fgfa-2.2-Grl-1-10.1-(Cdx-1, Csfmr, Pdgfrb, Pdea, Rps14)-2.1-Adrb-2-22.9-Mbp...
  56. ncbi Cloning and characterization of a novel upstream untranslated exon of the mouse Fgf-1 gene
    K V Hackshaw
    Department of Internal Medicine, Ohio State University, William H Davis Medical Research Center, Columbus 43210, USA
    Gene 180:131-5. 1996
    Fibroblast growth factor 1 (FGF-1 or aFGF), is the prototype member of the heparin-binding growth factors which are capable of angiogenesis in vivo...
  57. ncbi FGF-1 and FGF-7 induce distinct patterns of growth and differentiation in embryonic lung epithelium
    W V Cardoso
    The Pulmonary Center, Department of Medicine, Boston University School of Medicine, Massachusetts 02118, USA
    Dev Dyn 208:398-405. 1997
    ..By using mesenchyme-free lung epithelial cultures we show that FGF-1 (aFGF) and FGF-7 (KGF) produce different effects in the developing lung...
  58. ncbi Neuropeptide Y receptor genes mapped in human and mouse: receptors with high affinity for pancreatic polypeptide are not clustered with receptors specific for neuropeptide Y and peptide YY
    C M Lutz
    Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Genomics 46:287-90. 1997
    ..The physical association of these receptor genes correlates with ligand-binding properties, rather than sequence identity, and suggests a complex evolutionary relationship...
  59. ncbi Cloning and characterization of a novel form of mouse fibroblast growth factor-1 (FGF-1) mRNA, FGF-1.G: differential expression of FGF-1 and FGF-1.G mRNAs during embryonic development and in postnatal tissues
    Y Zhang
    Department of Internal Medicine, Ohio State University, William H Davis Medical Research Center, Columbus 43210, USA
    Biochim Biophys Acta 1521:45-58. 2001
    ..On the other hand, the parallel decrease of both FGF-1 and FGF-1.G mRNA levels we observed in the aging mouse kidney and liver suggests a role of FGF-1.G in normal cellular maintenance and survival...
  60. ncbi The expression of fibroblast growth factors and their receptors in the embryonic and neonatal mouse inner ear
    J O Pickles
    Vision, Touch and Hearing Research Centre, Department of Physiology and Pharmacology, University of Queensland, 4072, Brisbane, QLD, Australia
    Hear Res 155:54-62. 2001
    ..The expression of the b and c variants of the FGF receptors, together with the expression of the ligands FGF1, FGF2, FGF3, FGF7, FGF8b and FGF8c, was determined by quantitative reverse transcription-polymerase chain reaction ..
  61. ncbi Expression of members of the Fgf family and their receptors during midfacial development
    M Bachler
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030, Vienna, Austria
    Mech Dev 100:313-6. 2001
    ..their function during craniofacial development we have analyzed the expression of 18 members of the Fgf family (Fgf1-15, -17, -18 and -20) and the four members of the FGF-receptor family in the prospective midfacial region between ..
  62. ncbi Signaling and transcriptional regulation in early mammalian eye development: a link between FGF and MITF
    M Nguyen
    Laboratory of Developmental Neurogenetics, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    Development 127:3581-91. 2000
    ....
  63. ncbi Perlecan is essential for cartilage and cephalic development
    E Arikawa-Hirasawa
    Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA
    Nat Genet 23:354-8. 1999
    ..Our findings suggest that these molecules affect similar signalling pathways...
  64. ncbi Cloning and expression of a murine histone deacetylase 3 (mHdac3) cDNA and mapping to a region of conserved synteny between murine chromosome 18 and human chromosome 5
    F Dangond
    Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell Biol Res Commun 2:91-6. 1999
    ..3-q32 telomeric to the cytokine gene cluster. Transfection of mHdac3 into HeLa cells led to accumulation in G2/M. Our results suggest a cell cycle function for murine Hdac3, reflecting the complex regulatory roles of this gene family...
  65. ncbi Initiation of mammalian liver development from endoderm by fibroblast growth factors
    J Jung
    Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Box G J363, Providence, RI 02912, USA
    Science 284:1998-2003. 1999
    ..Treatment of isolated foregut endoderm from mouse embryos with FGF1 or FGF2, but not FGF8, was sufficient to replace cardiac mesoderm as an inducer of the liver gene expression ..
  66. ncbi FGF signaling in mouse gastrulation and anteroposterior patterning
    J Rossant
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Cold Spring Harb Symp Quant Biol 62:127-33. 1997
  67. pmc Fibroblast growth factor 2 control of vascular tone
    M Zhou
    Department of Molecular Genetics, University of Cincinnati College of Medicine, Ohio 45267, USA
    Nat Med 4:201-7. 1998
    ..These results force us to reconsider the function of FGF2 in vascular development and homeostasis in terms of vascular tone control...
  68. ncbi Fibroblast growth factor 10 (FGF10) and branching morphogenesis in the embryonic mouse lung
    S Bellusci
    Department of Cell Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2175, USA
    Development 124:4867-78. 1997
    ..This response involves an increase in the rate of endodermal cell proliferation. The activity of FGF1, FGF7 and FGF10 was also tested directly on isolated endoderm in Matrigel culture...
  69. ncbi Embryonic submandibular gland morphogenesis: stage-specific protein localization of FGFs, BMPs, Pax6 and Pax9 in normal mice and abnormal SMG phenotypes in FgfR2-IIIc(+/Delta), BMP7(-/-) and Pax6(-/-) mice
    Tina Jaskoll
    Laboratory for Developmental Genetics, University of Southern California, Los Angeles, CA 90089 0641, USA
    Cells Tissues Organs 170:83-98. 2002
    ..Finally, our observations of abnormal SMGs in BMP7(-/-) and Pax6(-/-) indicate that both BMP7 and Pax6 play important roles during embryonic SMG branching morphogenesis...
  70. ncbi Fibroblast-growth-factor receptor mutations in human skeletal disorders
    M Muenke
    Children s Hospital of Philadelphia, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia 19104 4399, USA
    Trends Genet 11:308-13. 1995
    ..Comparison of these specific mutations with the resulting phenotypes is now providing new insight into the role of these receptors in normal and abnormal bone development...
  71. ncbi Genetic localization of Cd63, a member of the transmembrane 4 superfamily, reveals two distinct loci in the mouse genome
    B Gwynn
    The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine, 04609, USA
    Genomics 35:389-91. 1996
    ..The second locus maps to mouse Chr 18 in a region that bears no known human CD63-related genes. No SPD has been localized to these regions of either the mouse or the human chromosomes...
  72. ncbi Role of FGF10/FGFR2b signaling during mammary gland development in the mouse embryo
    Arnaud André Mailleux
    UMR144 CNRS Institut Curie, 26 rue d Ulm 75248 Paris Cedex 05, France
    Development 129:53-60. 2002
    ..Our results also suggest that FGF signaling is involved in the maintenance of mammary bud 4, and that Fgf10 deficient epithelium can undergo branching morphogenesis into the mammary fat pad precursor...
  73. doi Localization patterns of fibroblast growth factor 1 and its receptors FGFR1 and FGFR2 in postnatal mouse retina
    Elisabetta Catalani
    Dipartimento di Scienze Ambientali, Universita della Tuscia, Largo dell Università snc, Blocco D, 01100, Viterbo, Italy
    Cell Tissue Res 336:423-38. 2009
    ..Here, we report a detailed double-label immunohistochemical investigation of the localization patterns of FGF1 and its receptors FGFR1 and FGFR2 in adult and early postnatal mouse retinas...
  74. pmc Genomic structure and chromosomal mapping of the mouse N-cadherin gene
    S Miyatani
    Department of Biophysics, Faculty of Science, Kyoto University, Japan
    Proc Natl Acad Sci U S A 89:8443-7. 1992
    ..The E- and P-cadherin genes are tightly linked and located on chromosome 8 in this species. Thus, N-cadherin is unlinked to these other cadherin loci...
  75. ncbi Chromosomal localizations of mouse Fgf2 and Fgf5 genes
    M G Mattei
    U 242 INSERM, Hopital d Enfants de la Timone, Marseille, France
    Mamm Genome 2:135-7. 1992
  76. ncbi Human endothelial cell growth factor: cloning, nucleotide sequence, and chromosome localization
    M Jaye
    Science 233:541-5. 1986
    ..This property is shared by human interleukin-1, which is approximately 30 percent homologous to ECGF...
  77. ncbi FGF is an essential regulator of the fifth cell division in preimplantation mouse embryos
    N Chai
    Department of Cell and Molecular Biology, Northwestern University Medical School, Chicago, Illinois 60611, USA
    Dev Biol 198:105-15. 1998
    ..The signal requirement for FGF is cell autonomous, but is not required to prevent cell death. This provides the first evidence for the necessity of a growth factor before implantation...
  78. ncbi Lack of FGF-1 overexpression during autoimmune nephritis in the kidneys of MRL lpr/lpr mice
    F Madiai
    Department of Internal Medicine, The Ohio State University, Columbus 43210, USA
    Res Commun Mol Pathol Pharmacol 103:37-44. 1999
    ..These results suggest that FGF-1 may not be involved in the pathogenesis of autoimmune nephritis in MRL lpr/lpr mice...

Research Grants5

  1. Gene Regulatory Signals for Beta Cell Development
    Kenneth Zaret; Fiscal Year: 2007
    ..By sharing technology and information from our work with the BCBC, our basic developmental studies will be more rapidly translated to develop cures for diabetes ..
  2. TRANS-ACTING FACTORS CAUSING CELL SPECIFIC GENE CONTROL
    Kenneth Zaret; Fiscal Year: 2007
    ..The findings will apply to diverse developmental contexts and adult pathologies, and enable rational approaches to differentiate proeenitor and stem cell populations for cell-based tissue therapies and research. ..
  3. Gene Regulatory Signals for Beta Cell Development
    Kenneth Zaret; Fiscal Year: 2007
    ..Bysharing technology and information from our work with the BCBC, our basic developmental studies will be more rapidly translated to develop cures for diabetes. ..