Gene Symbol: Fgd2
Description: FYVE, RhoGEF and PH domain containing 2
Alias: Tcd-2, Tcd2, ZFYVE4, tcs-2, tcs2, FYVE, RhoGEF and PH domain-containing protein 2, Fgd1 family, member 2, Fgd2-like protein, faciogenital dysplasia homolog 2, faciogenital dysplasia protein 2, t-complex distorter 2
Species: mouse
Products:     Fgd2

Top Publications

  1. Pasteris N, Gorski J. Isolation, characterization, and mapping of the mouse and human Fgd2 genes, faciogenital dysplasia (FGD1; Aarskog syndrome) gene homologues. Genomics. 1999;60:57-66 pubmed
    ..Here we report the use of degenerate PCR to isolate and characterize the mouse and human Fgd2 genes, new members of the FGD1 gene family...
  2. Samant S, Ogunkua O, Hui L, Fossella J, Pilder S. The T complex distorter 2 candidate gene, Dnahc8, encodes at least two testis-specific axonemal dynein heavy chains that differ extensively at their amino and carboxyl termini. Dev Biol. 2002;250:24-43 pubmed
    ..The cumulative data imply that Dnahc8 may have acquired functional plasticity in the testis through the tightly controlled expression of both typical and unusual isoforms. ..
  3. Wallace L, Erhart M. Recombination within mouse t haplotypes has replaced significant segments of t-specific DNA. Mamm Genome. 2008;19:263-71 pubmed publisher
    ..The 2-Mbp segment is located in a region that may contain the t-complex distorter gene Tcd2. One of the nine loci examined in this study is Fgd2, a gene that has been proposed to encode Tcd2...
  4. Huber C, Martensson A, Bokoch G, Nemazee D, Gavin A. FGD2, a CDC42-specific exchange factor expressed by antigen-presenting cells, localizes to early endosomes and active membrane ruffles. J Biol Chem. 2008;283:34002-12 pubmed publisher
    ..In its first characterization, we find that FGD2 is expressed in antigen-presenting cells, including B lymphocytes, macrophages, and dendritic cells...
  5. Himmelbauer H, Artzt K, Barlow D, Fischer Lindahl K, Lyon M, Klein J, et al. Encyclopedia of the mouse genome III. October 1993. Mouse chromosome 17. Mamm Genome. 1993;4 Spec No:S230-52 pubmed
  6. Sowden J, Morrison K, Schofield J, Putt W, Edwards Y. A novel cDNA with homology to an RNA polymerase II elongation factor maps to human chromosome 5q31 (TCEB1L) and to mouse chromosome 11 (Tceb1l). Genomics. 1995;29:145-51 pubmed
    ..These observations are consistent with Tceb1l being an RNA polymerase II elongation factor and suggest that Tceb1l/p15-like peptides may be a new family of proteins that influence RNA elongation. ..
  7. Samant S, Fossella J, Silver L, Pilder S. Mapping and cloning recombinant breakpoints demarcating the hybrid sterility 6-specific sperm tail assembly defect. Mamm Genome. 1999;10:88-94 pubmed
    ..combinations of the t complex have revealed a 1-cM candidate locus, Hst6, for the distal-most of these factors, Tcd/Tcs2. Males heterozygous for the M...
  8. Willison K. Distorting sex ratios. Nature. 1999;402:131-2 pubmed
  9. Erhart M, Lekgothoane S, Grenier J, Nadeau J. Pattern of segmental recombination in the distal inversion of mouse t haplotypes. Mamm Genome. 2002;13:438-44 pubmed
    ..at molecular markers in the vicinity of a gene, Dnahc8, that is a candidate for the t complex distorter locus Tcd2. While it is unclear whether segmental exchanges have included the Tcd2 gene, it is apparent that several ..

More Information


  1. Lyon M. Male sterility of the mouse t-complex is due to homozygosity of the distorter genes. Cell. 1986;44:357-63 pubmed
    ..Thus, the relationship between the various properties of the t-complex can now be understood. ..
  2. Lyon M. Transmission ratio distortion in mouse t-haplotypes is due to multiple distorter genes acting on a responder locus. Cell. 1984;37:621-8 pubmed
    ..In the absence of Tcr the distorters are transmitted normally. The system is compared with the SD system of Drosophila. ..
  3. Bauer H, VĂ©ron N, Willert J, Herrmann B. The t-complex-encoded guanine nucleotide exchange factor Fgd2 reveals that two opposing signaling pathways promote transmission ratio distortion in the mouse. Genes Dev. 2007;21:143-7 pubmed
    ..Here we show that Fgd2, encoding a Rho guanine nucleotide exchange factor, maps to the Tcd2 region...