Gene Symbol: Fgb
Description: fibrinogen beta chain
Alias: 2510049G14Rik, fibrinogen beta chain, fibrinogen, B beta polypeptide
Species: mouse
Products:     Fgb

Top Publications

  1. Chan J, Cornelissen I, Collen D, Ploplis V, Castellino F. Combined factor VII/protein C deficiency results in intrauterine coagulopathy in mice. J Clin Invest. 2000;105:897-903 pubmed
    ..The presence of fibrin in embryos in the absence of fetal FVII suggests that significant clot-generating potential exists outside of the embryonic factor VII-dependent pathway. ..
  2. Rosen E, Chan J, Idusogie E, Clotman F, Vlasuk G, Luther T, et al. Mice lacking factor VII develop normally but suffer fatal perinatal bleeding. Nature. 1997;390:290-4 pubmed
    ..Thus, the TF-/- embryonic lethal and the FVII-/- survival-phenotypes suggest a role for TF during embryogenesis beyond fibrin formation. ..
  3. Jalbert L, Rosen E, Moons L, Chan J, Carmeliet P, Collen D, et al. Inactivation of the gene for anticoagulant protein C causes lethal perinatal consumptive coagulopathy in mice. J Clin Invest. 1998;102:1481-8 pubmed
  4. Broze G. Tissue factor pathway inhibitor gene disruption. Blood Coagul Fibrinolysis. 1998;9 Suppl 1:S89-92 pubmed
    ..Human TFPI-deficient embryos may suffer a similar fate as an individual with TFPI deficiency has not been identified. ..
  5. Tolhurst G, Vial C, Leon C, Gachet C, Evans R, Mahaut Smith M. Interplay between P2Y(1), P2Y(12), and P2X(1) receptors in the activation of megakaryocyte cation influx currents by ADP: evidence that the primary megakaryocyte represents a fully functional model of platelet P2 receptor signaling. Blood. 2005;106:1644-51 pubmed
    ..Thus, direct stimulation of P2Y(1) and P2Y(12) receptors, together with autocrine P2X(1) activation, is responsible for the activation of nonselective cation currents by the platelet agonist ADP. ..
  6. Mills K, Mathews K, Scherpbier Heddema T, Schelper R, Schmalzel R, Bailey H, et al. Genetic mapping near the myd locus on mouse chromosome 8. Mamm Genome. 1995;6:278-80 pubmed
    ..The mutation maps between D8Mit30 and D8Mit75, an interval that is flanked by genes with human homologs at distal 4q. These results are consistent with the possibility that myd is the mouse homolog of FSHD. ..
  7. Sakao E, Ishihara A, Horikawa K, Akiyama M, Arai M, Kato M, et al. Two-peaked synchronization in day/night expression rhythms of the fibrinogen gene cluster in the mouse liver. J Biol Chem. 2003;278:30450-7 pubmed
    ..The fibrinogen gene locus provides a unique system for the study of two-peaked day/night rhythms of gene expression in a synchronized form. ..
  8. Pfister S, Jones V, Power M, Truisi G, Khoo P, Steiner K, et al. Sox17-dependent gene expression and early heart and gut development in Sox17-deficient mouse embryos. Int J Dev Biol. 2011;55:45-58 pubmed publisher
    ..This is associated with the defective development of the heart in the mutant embryos, which is accompanied by localised loss of Myocd-expressing cardiogenic progenitors and the malformation of the anterior intestinal portal. ..
  9. Chauvet C, Bois Joyeux B, Fontaine C, Gervois P, Bernard M, Staels B, et al. The gene encoding fibrinogen-beta is a target for retinoic acid receptor-related orphan receptor alpha. Mol Endocrinol. 2005;19:2517-26 pubmed
    ..Taken together, these data add further evidence for an important role of RORalpha in the control of liver gene expression with potential pathophysiological consequences on coagulation and cardiovascular risk. ..

More Information


  1. Weisel J. Fibrinogen and fibrin. Adv Protein Chem. 2005;70:247-99 pubmed
    ..Fibrinogen-like domains originated early in evolution, and it is likely that their specific and tightly controlled intermolecular interactions are involved in other aspects of cellular function and developmental biology. ..
  2. Ishiguro K, Kojima T, Kadomatsu K, Nakayama Y, Takagi A, Suzuki M, et al. Complete antithrombin deficiency in mice results in embryonic lethality. J Clin Invest. 2000;106:873-8 pubmed
    ..These findings suggest that antithrombin is essential for embryonic survival and that it plays an important role in regulation of blood coagulation in the myocardium and liver. ..
  3. Zovein A, Luque A, Turlo K, Hofmann J, Yee K, Becker M, et al. Beta1 integrin establishes endothelial cell polarity and arteriolar lumen formation via a Par3-dependent mechanism. Dev Cell. 2010;18:39-51 pubmed publisher
    ..Combined, our findings demonstrate that beta1 integrin functions upstream of Par3 as part of a molecular cascade required for endothelial cell polarity and lumen formation. ..
  4. Iwaki T, Sandoval Cooper M, Paiva M, Kobayashi T, Ploplis V, Castellino F. Fibrinogen stabilizes placental-maternal attachment during embryonic development in the mouse. Am J Pathol. 2002;160:1021-34 pubmed
  5. Yin Z, Huang Z, Cui J, Fiehler R, Lasky N, Ginsburg D, et al. Prothrombotic phenotype of protein Z deficiency. Proc Natl Acad Sci U S A. 2000;97:6734-8 pubmed
    ..The results indicate that PZ plays a physiologically important role in the regulation of coagulation. ..
  6. Zacharowski K, Zacharowski P, Friedl P, Mastan P, Koch A, Boehm O, et al. The effects of the fibrin-derived peptide Bbeta(15-42) in acute and chronic rodent models of myocardial ischemia-reperfusion. Shock. 2007;27:631-7 pubmed
    ..In rodents, Bbeta(15-42) inhibits proinflammatory cytokine release and is cardioprotective during ischemia-reperfusion injury. ..
  7. Ahn H, Zamolodchikov D, Cortes Canteli M, Norris E, Glickman J, Strickland S. Alzheimer's disease peptide beta-amyloid interacts with fibrinogen and induces its oligomerization. Proc Natl Acad Sci U S A. 2010;107:21812-7 pubmed publisher
    ..Overall, our study indicates that the interaction between A? and fibrinogen may be an important contributor to the vascular abnormalities found in AD. ..
  8. Crosswhite P, Podsiadlowska J, Curtis C, Gao S, Xia L, Srinivasan R, et al. CHD4-regulated plasmin activation impacts lymphovenous hemostasis and hepatic vascular integrity. J Clin Invest. 2016;126:2254-66 pubmed publisher
    ..These results highlight the susceptibility of LV thrombi and liver sinusoidal vessels to plasmin-mediated damage and demonstrate the importance of CHD4 in regulating embryonic plasmin activation after mid-gestation. ..
  9. Gu J, Crawley J, Ferrell G, Zhang F, Li W, Esmon N, et al. Disruption of the endothelial cell protein C receptor gene in mice causes placental thrombosis and early embryonic lethality. J Biol Chem. 2002;277:43335-43 pubmed
    ..We conclude that EPCR is essential for normal embryonic development. Moreover, EPCR plays a key role in preventing thrombosis at the maternal-embryonic interface. ..
  10. Rezaee F, Maas A, Verheijen J, Koopman J. Increased hepatic fibrinogen Bbeta-gene transcription is not enough to increase plasma fibrinogen levels. A transgenic mouse study. Thromb Haemost. 2001;85:1025-30 pubmed
  11. Chan J, Ganopolsky J, Cornelissen I, Suckow M, Sandoval Cooper M, Brown E, et al. The characterization of mice with a targeted combined deficiency of protein c and factor XI. Am J Pathol. 2001;158:469-79 pubmed
  12. Yang H, Reheman A, Chen P, Zhu G, Hynes R, Freedman J, et al. Fibrinogen and von Willebrand factor-independent platelet aggregation in vitro and in vivo. J Thromb Haemost. 2006;4:2230-7 pubmed
    ..beta(3) integrin, thrombin, and Ca(2+) play critical roles in this Fg/VWF-independent aggregation, and both plasma and platelet granule proteins contribute to this process. ..
  13. Krishnamoorthy A, Ajay A, Hoffmann D, Kim T, Ramirez V, Campanholle G, et al. Fibrinogen ?-derived B?(15-42) peptide protects against kidney ischemia/reperfusion injury. Blood. 2011;118:1934-42 pubmed publisher
    ..Given that kidney regeneration is a major determinant of outcome for patients with kidney damage, these results provide new opportunities for the use of Fg in diagnosis, prevention, and therapeutic interventions in kidney disease. ..