Fcgr2b

Summary

Gene Symbol: Fcgr2b
Description: Fc receptor, IgG, low affinity IIb
Alias: AI528646, CD32, F630109E10Rik, Fc[g]RII, FcgRII, Fcgr2, Fcgr2a, Fcr-2, Fcr-3, Ly-17, Ly-m20, LyM-1, Lym-1, fcRII, low affinity immunoglobulin gamma Fc region receptor II-b, Fc gamma RIIB, Fc-gamma-RII, FcgammaRIIB, fc gamma receptor IIB, fc-gamma RII, fc-gamma-RIIB, igG Fc receptor II beta, low affinity immunoglobulin gamma Fc region receptor II, lymphocyte antigen 17
Species: mouse
Products:     Fcgr2b

Top Publications

  1. Luan J, Monteiro R, Sautes C, Fluteau G, Eloy L, Fridman W, et al. Defective Fc gamma RII gene expression in macrophages of NOD mice: genetic linkage with up-regulation of IgG1 and IgG2b in serum. J Immunol. 1996;157:4707-16 pubmed
    ..chromosome 1, close to the fcgr2 locus encoding the low-affinity type II receptor for the Fc portion of IgG (Fc gamma RII)...
  2. Bulliard Y, Jolicoeur R, Windman M, Rue S, Ettenberg S, Knee D, et al. Activating Fc ? receptors contribute to the antitumor activities of immunoregulatory receptor-targeting antibodies. J Exp Med. 2013;210:1685-93 pubmed publisher
    ..These findings may have broad implications for antibody engineering efforts aimed at enhancing the therapeutic activity of immunomodulatory antibodies. ..
  3. Gjertsson I, Kleinau S, Tarkowski A. The impact of Fcgamma receptors on Staphylococcus aureus infection. Microb Pathog. 2002;33:145-52 pubmed
    ..aureus infection. We conclude that expression of Fcgamma receptor II is of importance during S. aureus infection. ..
  4. Xiang Z, Cutler A, Brownlie R, Fairfax K, Lawlor K, Severinson E, et al. FcgammaRIIb controls bone marrow plasma cell persistence and apoptosis. Nat Immunol. 2007;8:419-29 pubmed
    ..We found here that the inhibitory Fc receptor FcgammaRIIb was expressed on plasma cells and controlled their persistence in the bone marrow...
  5. Xiu Y, Nakamura K, Abe M, Li N, Wen X, Jiang Y, et al. Transcriptional regulation of Fcgr2b gene by polymorphic promoter region and its contribution to humoral immune responses. J Immunol. 2002;169:4340-6 pubmed
    ..We earlier found deletion polymorphism in the Fcgr2b promoter region among mouse strains in which systemic autoimmune disease-prone NZB, BXSB, MRL, and autoimmune ..
  6. Waisberg M, Tarasenko T, Vickers B, Scott B, Willcocks L, Molina Cruz A, et al. Genetic susceptibility to systemic lupus erythematosus protects against cerebral malaria in mice. Proc Natl Acad Sci U S A. 2011;108:1122-7 pubmed publisher
  7. Sharp P, Martin Ramirez J, Mangsbo S, Boross P, Pusey C, Touw I, et al. Fc?RIIb on myeloid cells and intrinsic renal cells rather than B cells protects from nephrotoxic nephritis. J Immunol. 2013;190:340-8 pubmed publisher
    ..Where there was a lack of Fc?RIIb on circulating myeloid cells, expression of Fc?RIIb on intrinsic renal cells provided an additional level of protection from Ab-mediated glomerulonephritis...
  8. Hamaguchi Y, Xiu Y, Komura K, Nimmerjahn F, Tedder T. Antibody isotype-specific engagement of Fcgamma receptors regulates B lymphocyte depletion during CD20 immunotherapy. J Exp Med. 2006;203:743-53 pubmed
    ..or blocked for stimulatory FcgammaRI, FcgammaRIII, FcgammaRIV, or FcR common gamma chain, or inhibitory FcgammaRIIB. IgG1 CD20 mAbs induced B cell depletion through preferential, if not exclusive, interactions with low-affinity ..
  9. Barrington R, Pozdnyakova O, Zafari M, Benjamin C, Carroll M. B lymphocyte memory: role of stromal cell complement and FcgammaRIIB receptors. J Exp Med. 2002;196:1189-99 pubmed
    To dissect the influence of CD21/CD35 and FcgammaRIIB in antigen retention and humoral memory, we used an adoptive transfer model in which antigen-primed B and T lymphocytes were given to sublethally irradiated wild-type mice or mice ..

More Information

Publications78

  1. Yajima K, Nakamura A, Sugahara A, Takai T. FcgammaRIIB deficiency with Fas mutation is sufficient for the development of systemic autoimmune disease. Eur J Immunol. 2003;33:1020-9 pubmed
    ..Here, we show that the gene for a unique inhibitory Fc receptor for IgG (Fc gamma RIIB) is a critical SLE suppressor. Fc gamma RIIB-deficient B6.Fas(lpr/lpr) (B6...
  2. Clatworthy M, Smith K. FcgammaRIIb balances efficient pathogen clearance and the cytokine-mediated consequences of sepsis. J Exp Med. 2004;199:717-23 pubmed
    ..Mice deficient in FcgammaRIIb, an inhibitory immunoglobulin G Fc receptor, have enhanced immune responses...
  3. Nimmerjahn F, Bruhns P, Horiuchi K, Ravetch J. FcgammaRIV: a novel FcR with distinct IgG subclass specificity. Immunity. 2005;23:41-51 pubmed
    ..These distinct binding affinities for the IgG subclasses to FcgammaRs account for their differential protective and pathogenic activities in vivo. ..
  4. Stein M, Mold C, Du Clos T. C-reactive protein binding to murine leukocytes requires Fc gamma receptors. J Immunol. 2000;164:1514-20 pubmed
    ..of Fc gamma R-deficient mice were examined: gamma-chain-deficient mice that lack Fc gamma RI and Fc gamma RIII, Fc gamma RII-deficient mice, and mice deficient in both gamma-chain and Fc gamma RII that lack all Fc gamma R...
  5. Pritchard N, Cutler A, Uribe S, Chadban S, Morley B, Smith K. Autoimmune-prone mice share a promoter haplotype associated with reduced expression and function of the Fc receptor FcgammaRII. Curr Biol. 2000;10:227-30 pubmed
    ..FcgammaRII-deficient mice are prone to immune-mediated disease [7] [8] [9]. The gene encoding FcgammaRII, Fcgr2, is contained in genetic susceptibility intervals in mouse models of SLE such as the New Zealand Black (NZB) ..
  6. Nimmerjahn F, Ravetch J. Divergent immunoglobulin g subclass activity through selective Fc receptor binding. Science. 2005;310:1510-2 pubmed
    ..We suggest that these highly predictable functions assigned by Fc binding will be an important consideration in the design of therapeutic antibodies and vaccines. ..
  7. Samsom J, van Berkel L, van Helvoort J, Unger W, Jansen W, Thepen T, et al. Fc gamma RIIB regulates nasal and oral tolerance: a role for dendritic cells. J Immunol. 2005;174:5279-87 pubmed
    ..In this study, we show that mice deficient in FcgammaRIIB failed to develop mucosal tolerance to OVA, and demonstrate in vitro and in vivo a critical role for this ..
  8. Bolland S, Yim Y, Tus K, Wakeland E, Ravetch J. Genetic modifiers of systemic lupus erythematosus in FcgammaRIIB(-/-) mice. J Exp Med. 2002;195:1167-74 pubmed
    b>FcgammaRIIB is a potent lupus susceptibility gene as demonstrated by the observation that mice deficient in this molecule develop spontaneous antinuclear antibodies (ANA) and fatal glomerulonephritis when on the C57BL/6 background...
  9. Mold C, Rodic Polic B, Du Clos T. Protection from Streptococcus pneumoniae infection by C-reactive protein and natural antibody requires complement but not Fc gamma receptors. J Immunol. 2002;168:6375-81 pubmed
    ..Injection of CRP protected wild-type, FcR gamma-chain-, Fc gamma RIIb-, and Fc gamma RIII-deficient mice from infection...
  10. Lin Q, Xiu Y, Jiang Y, Tsurui H, Nakamura K, Kodera S, et al. Genetic dissection of the effects of stimulatory and inhibitory IgG Fc receptors on murine lupus. J Immunol. 2006;177:1646-54 pubmed
    ..In lupus-prone BXSB mice, while stimulatory FcgammaRs are intact, inhibitory FcgammaRIIB expression is impaired because of promoter region polymorphism...
  11. Daeron M. Fc receptor biology. Annu Rev Immunol. 1997;15:203-34 pubmed
    ..FcR therefore appear as the subunits of multichain receptors whose constitution is not predetermined and which deliver adaptative messages as a function of the environment. ..
  12. Sundgren N, Zhu W, Yuhanna I, Chambliss K, Ahmed M, Tanigaki K, et al. Coupling of Fc? receptor I to Fc? receptor IIb by SRC kinase mediates C-reactive protein impairment of endothelial function. Circ Res. 2011;109:1132-40 pubmed publisher
    ..Similar mechanisms underlie eNOS antagonism by immune complex. Fc?RI and Fc?RIIB may be novel therapeutic targets for preventing endothelial dysfunction in inflammatory or immune complex-mediated conditions...
  13. Clatworthy M, Willcocks L, Urban B, Langhorne J, Williams T, Peshu N, et al. Systemic lupus erythematosus-associated defects in the inhibitory receptor FcgammaRIIb reduce susceptibility to malaria. Proc Natl Acad Sci U S A. 2007;104:7169-74 pubmed
    ..A defunctioning, SLE-associated polymorphism of the inhibitory receptor FcgammaRIIb is found at an increased frequency in African and Asian populations, broadly corresponding to areas where ..
  14. Mechetina L, Najakshin A, Alabyev B, Chikaev N, Taranin A. Identification of CD16-2, a novel mouse receptor homologous to CD16/Fc gamma RIII. Immunogenetics. 2002;54:463-8 pubmed
    ..RIII arose by an evolutionarily recent recombination, which brought together the extracellular domains from Fc gamma RII with the transmembrane/cytoplasmic region from the ancestor Fc gamma RIII...
  15. Tiller T, Kofer J, Kreschel C, Busse C, Riebel S, Wickert S, et al. Development of self-reactive germinal center B cells and plasma cells in autoimmune Fc gammaRIIB-deficient mice. J Exp Med. 2010;207:2767-78 pubmed publisher
    Abnormalities in expression levels of the IgG inhibitory Fc gamma receptor IIB (Fc?RIIB) are associated with the development of immunoglobulin (Ig) G serum autoantibodies and systemic autoimmunity in mice and humans...
  16. Hogarth P, Witort E, Hulett M, Bonnerot C, Even J, Fridman W, et al. Structure of the mouse beta Fc gamma receptor II gene. J Immunol. 1991;146:369-76 pubmed
    We have isolated and deduced the structure of the beta Fc gamma RII gene from the mouse. This gene spans approximately 18 kb of DNA; the structure and nucleotide sequence has been determined and potential regulatory sites identified...
  17. Fukuyama H, Nimmerjahn F, Ravetch J. The inhibitory Fcgamma receptor modulates autoimmunity by limiting the accumulation of immunoglobulin G+ anti-DNA plasma cells. Nat Immunol. 2005;6:99-106 pubmed
    Deletion of the gene encoding the Fc immunoglobulin G receptor IIB (FcgammaRIIB) results in a fulminant, lupus-like disease in C57BL/6 but not BALB/c mice...
  18. Jørgensen T, Alfaro J, Enriquez H, Jiang C, Loo W, Atencio S, et al. Development of murine lupus involves the combined genetic contribution of the SLAM and FcgammaR intervals within the Nba2 autoimmune susceptibility locus. J Immunol. 2010;184:775-86 pubmed publisher
    ..homeostasis of terminally differentiated B cells was found to be controlled by the FcgammaR interval where FcgammaRIIb-mediated apoptosis of germinal center B cells and plasma cells was impaired...
  19. Wernersson S, Karlsson M, Dahlstrom J, Mattsson R, Verbeek J, Heyman B. IgG-mediated enhancement of antibody responses is low in Fc receptor gamma chain-deficient mice and increased in Fc gamma RII-deficient mice. J Immunol. 1999;163:618-22 pubmed
    ..Mice lacking the gamma subunit of Fc receptors (FcRs) (FcR gamma-/-), Fc gamma RII (Fc gamma RII-/-), or Fc gamma RIII (Fc gamma RIII-/-) were immunized with BSA-2,4,6-trinitrophenyl (TNP) alone ..
  20. Takai T, Ono M, Hikida M, Ohmori H, Ravetch J. Augmented humoral and anaphylactic responses in Fc gamma RII-deficient mice. Nature. 1996;379:346-9 pubmed
    ..on both lymphoid and myeloid cells, the biological role of the low-affinity immunoglobulin-G receptor, Fc gamma RII, is not fully understood...
  21. Nakamura A, Yuasa T, Ujike A, Ono M, Nukiwa T, Ravetch J, et al. Fcgamma receptor IIB-deficient mice develop Goodpasture's syndrome upon immunization with type IV collagen: a novel murine model for autoimmune glomerular basement membrane disease. J Exp Med. 2000;191:899-906 pubmed
    ..receptor for immunoglobulin (Ig)G antibody expression and function, the type IIB Fc receptor for IgG (FcgammaRIIB)...
  22. Nigrovic P, Binstadt B, Monach P, Johnsen A, Gurish M, Iwakura Y, et al. Mast cells contribute to initiation of autoantibody-mediated arthritis via IL-1. Proc Natl Acad Sci U S A. 2007;104:2325-30 pubmed
    ..These findings illuminate a mechanism by which mast cells can participate in the pathogenesis of autoimmune inflammatory arthritis and provide insights of potential relevance to human rheumatoid arthritis. ..
  23. Brownlie R, Lawlor K, Niederer H, Cutler A, Xiang Z, Clatworthy M, et al. Distinct cell-specific control of autoimmunity and infection by FcgammaRIIb. J Exp Med. 2008;205:883-95 pubmed publisher
    b>FcgammaRIIb is an inhibitory Fc receptor expressed on B cells and myeloid cells. It is important in controlling responses to infection, and reduced expression or function predisposes to autoimmunity...
  24. Clynes R, Towers T, Presta L, Ravetch J. Inhibitory Fc receptors modulate in vivo cytotoxicity against tumor targets. Nat Med. 2000;6:443-6 pubmed
    ..Using a variety of syngenic and xenograft models, we demonstrate here that the inhibitory FcgammaRIIB molecule is a potent regulator of antibody-dependent cell-mediated cytotoxicity in vivo, modulating the ..
  25. Li F, Ravetch J. Inhibitory Fc? receptor engagement drives adjuvant and anti-tumor activities of agonistic CD40 antibodies. Science. 2011;333:1030-4 pubmed publisher
    ..This unexpected requirement for Fc?RIIB in enhancing CD40-mediated immune activation has direct implications for the design of agonistic antibodies to TNFR as therapeutics. ..
  26. Pisitkun P, Ha H, Wang H, Claudio E, Tivy C, Zhou H, et al. Interleukin-17 cytokines are critical in development of fatal lupus glomerulonephritis. Immunity. 2012;37:1104-15 pubmed publisher
  27. Yamamoto M, Kobayashi K, Ishikawa Y, Nakata K, Funada Y, Kotani Y, et al. The inhibitory effects of intravenous administration of rabbit immunoglobulin G on airway inflammation are dependent upon Fc? receptor IIb on CD11c(+) dendritic cells in a murine model. Clin Exp Immunol. 2010;162:315-24 pubmed publisher
    ..Targeting Fc portions of IgG and Fc? receptor IIb on CD11c(+) DCs in allergic asthma is a promising therapeutic strategy. ..
  28. Zhao M, Wigren M, Dunér P, Kolbus D, Olofsson K, Bjorkbacka H, et al. FcgammaRIIB inhibits the development of atherosclerosis in low-density lipoprotein receptor-deficient mice. J Immunol. 2010;184:2253-60 pubmed publisher
    ..However, the role of the inhibitory IgG receptor FcgammaRIIB in atherosclerosis has not been defined...
  29. Masuda A, Yoshida M, Shiomi H, Ikezawa S, Takagawa T, Tanaka H, et al. Fcgamma receptor regulation of Citrobacter rodentium infection. Infect Immun. 2008;76:1728-37 pubmed publisher
    ..rodentium infection, indicating that the critical role played by IgG in this infection is not mediated by IgG alone but is dependent upon this class of receptors. ..
  30. Ganesan L, Kim J, Wu Y, Mohanty S, Phillips G, Birmingham D, et al. Fc?RIIb on liver sinusoidal endothelium clears small immune complexes. J Immunol. 2012;189:4981-8 pubmed publisher
    ..5 h, respectively. RIIb on LSEC, a major scavenger, keeps SIC blood concentrations low and minimizes pathologic deposition of inflammatory immune complex...
  31. Muta T, Kurosaki T, Misulovin Z, Sanchez M, Nussenzweig M, Ravetch J. A 13-amino-acid motif in the cytoplasmic domain of Fc gamma RIIB modulates B-cell receptor signalling. Nature. 1994;368:70-3 pubmed
    The Fc receptor on B lymphocytes, Fc gamma RIIB (beta 1 isoform), helps to modulate B-cell activation triggered by the surface immunoglobulin complex...
  32. Kleinau S, Martinsson P, Heyman B. Induction and suppression of collagen-induced arthritis is dependent on distinct fcgamma receptors. J Exp Med. 2000;191:1611-6 pubmed
    ..In comparison, DBA/1 mice lacking FcgammaRII developed an augmented IgG anticollagen response and arthritis. These observations suggest a crucial role of FcgammaRI and FcgammaRIII in triggering autoimmune arthritis. ..
  33. Ravetch J, Kinet J. Fc receptors. Annu Rev Immunol. 1991;9:457-92 pubmed
    ..Thus, the Fc receptors provide an example of a class of molecules in which conserved domains are combined with divergent sequences to yield a diversity of function. ..
  34. Jiang Y, Hirose S, Abe M, Sanokawa Akakura R, Ohtsuji M, Mi X, et al. Polymorphisms in IgG Fc receptor IIB regulatory regions associated with autoimmune susceptibility. Immunogenetics. 2000;51:429-35 pubmed
    ..We found that there are three types of polymorphisms in the reported FcgammaRIIB transcription regulatory regions in mouse strains...
  35. Avalos A, Uccellini M, Lenert P, Viglianti G, Marshak Rothstein A. Fc?RIIB regulation of BCR/TLR-dependent autoreactive B-cell responses. Eur J Immunol. 2010;40:2692-8 pubmed publisher
    ..These results demonstrate that Fc?RIIB can effectively modulate both BCR/TLR9 and BCR/TLR7 endosomal-dependent activation of autoreactive B cells. ..
  36. Li F, Ravetch J. Antitumor activities of agonistic anti-TNFR antibodies require differential Fc?RIIB coengagement in vivo. Proc Natl Acad Sci U S A. 2013;110:19501-6 pubmed publisher
  37. Hazenbos W, Gessner J, Hofhuis F, Kuipers H, Meyer D, Heijnen I, et al. Impaired IgG-dependent anaphylaxis and Arthus reaction in Fc gamma RIII (CD16) deficient mice. Immunity. 1996;5:181-8 pubmed
    ..These results indicate a prominent role for Fc gamma RIII in inflammatory and anaphylactic responses, making this receptor a potential target in immunotherapy...
  38. Rao S, Vora K, Manser T. Differential expression of the inhibitory IgG Fc receptor FcgammaRIIB on germinal center cells: implications for selection of high-affinity B cells. J Immunol. 2002;169:1859-68 pubmed
    The murine low-affinity receptor for IgG, FcgammaRIIB, mediates inhibition of B cell receptor-triggered events in primary B cells...
  39. Paul E, Nelde A, Verschoor A, Carroll M. Follicular exclusion of autoreactive B cells requires FcgammaRIIb. Int Immunol. 2007;19:365-73 pubmed
    ..To study the role of Fcgamma receptor IIb (FcgammaRIIb) in peripheral B cell tolerance, FcgammaRIIb(-/-) mice were crossed with C57BL/6 mice bearing a site-directed ..
  40. Sutterwala F, Noel G, Salgame P, Mosser D. Reversal of proinflammatory responses by ligating the macrophage Fcgamma receptor type I. J Exp Med. 1998;188:217-22 pubmed
    ..This reciprocal alteration in the pattern of macrophage cytokine production illustrates a potentially important role for FcgammaR-mediated clearance in suppressing macrophage proinflammatory responses. ..
  41. Yuasa T, Kubo S, Yoshino T, Ujike A, Matsumura K, Ono M, et al. Deletion of fcgamma receptor IIB renders H-2(b) mice susceptible to collagen-induced arthritis. J Exp Med. 1999;189:187-94 pubmed
    ..Biochemical and genetic studies indicate that the type IIB low-affinity receptor for immunoglobulin (Ig)G (FcgammaRIIB) inhibits cellular activation triggered through antibody or immune complexes and may be an important component ..
  42. Li F, Ravetch J. Apoptotic and antitumor activity of death receptor antibodies require inhibitory Fc? receptor engagement. Proc Natl Acad Sci U S A. 2012;109:10966-71 pubmed publisher
  43. Nakamura A, Nukiwa T, Takai T. Deregulation of peripheral B-cell development in enhanced severity of collagen-induced arthritis in FcgammaRIIB-deficient mice. J Autoimmun. 2003;20:227-36 pubmed
    Accumulating evidence indicates that the type IIB Fc receptor for IgG (FcgammaRIIB) plays a pivotal role in maintaining peripheral tolerance by suppressing excessive humoral and cellular immune responses...
  44. Mendez Fernandez Y, Stevenson B, Diehl C, Braun N, Wade N, Covarrubias R, et al. The inhibitory Fc?RIIb modulates the inflammatory response and influences atherosclerosis in male apoE(-/-) mice. Atherosclerosis. 2011;214:73-80 pubmed publisher
    ..These data are the first to describe a significant in vivo effect for Fc?RIIb in modulating the cytokine response in the aorta in male apoE(-/-) mice. ..
  45. Boross P, Arandhara V, Martin Ramirez J, Santiago Raber M, Carlucci F, Flierman R, et al. The inhibiting Fc receptor for IgG, Fc?RIIB, is a modifier of autoimmune susceptibility. J Immunol. 2011;187:1304-13 pubmed publisher
    ..In the presence of the Yaa lupus-susceptibility locus, Fc?RIIB(B6)(-/-) mice do develop lethal lupus, confirming that Fc?RIIB deficiency only amplifies spontaneous autoimmunity determined by other loci. ..
  46. Rahman Z, Manser T. Failed up-regulation of the inhibitory IgG Fc receptor Fc gamma RIIB on germinal center B cells in autoimmune-prone mice is not associated with deletion polymorphisms in the promoter region of the Fc gamma RIIB gene. J Immunol. 2005;175:1440-9 pubmed
    b>FcgammaRIIB, a low-affinity FcR for IgG, inhibits BCR-mediated activation when these two receptors are co-cross-linked by Ags and IgG-containing immune complexes...
  47. Dharajiya N, Vaidya S, Murai H, Cardenas V, Kurosky A, Boldogh I, et al. FcgammaRIIb inhibits allergic lung inflammation in a murine model of allergic asthma. PLoS ONE. 2010;5:e9337 pubmed publisher
    ..b>Fc gamma receptor IIb (FcgammaRIIb), an inhibitory IgG receptor, has recently emerged as a negative regulator of allergic ..
  48. Smith P, DiLillo D, Bournazos S, Li F, Ravetch J. Mouse model recapitulating human Fc? receptor structural and functional diversity. Proc Natl Acad Sci U S A. 2012;109:6181-6 pubmed publisher
  49. Okazaki T, Otaka Y, Wang J, Hiai H, Takai T, Ravetch J, et al. Hydronephrosis associated with antiurothelial and antinuclear autoantibodies in BALB/c-Fcgr2b-/-Pdcd1-/- mice. J Exp Med. 2005;202:1643-8 pubmed
    ..diseases by epistatic effects of two immunoinhibitory receptors, low affinity type IIb Fc receptor for IgG (FcgammaRIIB) and programmed cell death 1 (PD-1)...
  50. Qin D, Wu J, Vora K, Ravetch J, Szakal A, Manser T, et al. Fc gamma receptor IIB on follicular dendritic cells regulates the B cell recall response. J Immunol. 2000;164:6268-75 pubmed
    ..FDCs in GCs, but not in primary follicles, express high levels of the IgG Fc receptor Fc gamma RIIB. This regulated expression of Fc gamma RIIB on FDC and its relation to recall Ab responses were examined both ..
  51. Takizawa F, Adamczewski M, Kinet J. Identification of the low affinity receptor for immunoglobulin E on mouse mast cells and macrophages as Fc gamma RII and Fc gamma RIII. J Exp Med. 1992;176:469-75 pubmed
    ..In this paper, we show that Fc gamma RII and Fc gamma RIII, but not Mac-2, on mouse mast cells and macrophages bind IgE-immune complexes...
  52. Karlsson M, Wernersson S, Díaz de Ståhl T, Gustavsson S, Heyman B. Efficient IgG-mediated suppression of primary antibody responses in Fcgamma receptor-deficient mice. Proc Natl Acad Sci U S A. 1999;96:2244-9 pubmed
    ..understood, but it has been proposed that IgG/erythrocyte complexes bind to the inhibitory Fc receptor for IgG (FcgammaRIIB) on the B cell surface, thereby triggering negative signals that turn off the B cell...
  53. Mineo C, Gormley A, Yuhanna I, Osborne Lawrence S, Gibson L, Hahner L, et al. FcgammaRIIB mediates C-reactive protein inhibition of endothelial NO synthase. Circ Res. 2005;97:1124-31 pubmed
    ..IgG, the known ligand for Fcgamma receptors, causes parallel okadaic acid-sensitive loss of eNOS function, FcgammaRIIB expression is demonstrable in endothelium, and heterologous expression studies reveal that CRP antagonism of ..
  54. Zhang Y, Liu S, Liu J, Zhang T, Shen Q, Yu Y, et al. Immune complex/Ig negatively regulate TLR4-triggered inflammatory response in macrophages through Fc gamma RIIb-dependent PGE2 production. J Immunol. 2009;182:554-62 pubmed
    ..Thus we provide new manner for the immune regulation and mechanistic explanation for nonpathogenic IC/Ig in the treatment of inflammatory or autoimmune diseases. ..
  55. Strait R, Morris S, Finkelman F. IgG-blocking antibodies inhibit IgE-mediated anaphylaxis in vivo through both antigen interception and Fc gamma RIIb cross-linking. J Clin Invest. 2006;116:833-41 pubmed
  56. Yada A, Ebihara S, Matsumura K, Endo S, Maeda T, Nakamura A, et al. Accelerated antigen presentation and elicitation of humoral response in vivo by FcgammaRIIB- and FcgammaRI/III-mediated immune complex uptake. Cell Immunol. 2003;225:21-32 pubmed
    ..and FcgammaRIII, are essential for inducing inflammatory responses, whereas a unique inhibitory FcgammaR, FcgammaRIIB, inhibits intracellular signaling upon ligation of IgG-immune complexes, and can suppress inflammation and ..
  57. Zhang H, Meng F, Chu C, Takai T, Lowell C. The Src family kinases Hck and Fgr negatively regulate neutrophil and dendritic cell chemokine signaling via PIR-B. Immunity. 2005;22:235-46 pubmed
    ..These data support a model in which the Src family kinases Hck and Fgr function as negative regulators of myeloid cell chemokine signaling by maintaining the tonic phosphorylation of PIR-B. ..
  58. Wang J, Bair A, King S, Shnayder R, Huang Y, Shieh C, et al. Ly6G ligation blocks recruitment of neutrophils via a ?2-integrin-dependent mechanism. Blood. 2012;120:1489-98 pubmed publisher
  59. Rahman Z, Alabyev B, Manser T. FcgammaRIIB regulates autoreactive primary antibody-forming cell, but not germinal center B cell, activity. J Immunol. 2007;178:897-907 pubmed
    The low-affinity FcR for IgG FcgammaRIIB suppresses the development of IgG autoantibodies and autoimmune disease in normal individuals, but how this effect is mediated is incompletely understood...
  60. Mero P, Zhang C, Huang Z, Kim M, Schreiber A, Grinstein S, et al. Phosphorylation-independent ubiquitylation and endocytosis of Fc gammaRIIA. J Biol Chem. 2006;281:33242-9 pubmed
    ..Endocytosis of Fc gammaRIIA is dependent on clathrin but independent of the adaptor protein AP-2. These findings point to a novel mechanism for ubiquitylation and endocytosis of this immunoreceptor. ..
  61. Corr M, Crain B. The role of FcgammaR signaling in the K/B x N serum transfer model of arthritis. J Immunol. 2002;169:6604-9 pubmed
  62. Moll T, Nitschke L, Carroll M, Ravetch J, Izui S. A critical role for Fc gamma RIIB in the induction of rheumatoid factors. J Immunol. 2004;173:4724-8 pubmed
    ..cells could be controlled specifically through recognition of IgG immune complexes by the low-affinity IgG FcR, FcgammaRIIB, a potent negative regulator of the BCR...
  63. Ujike A, Ishikawa Y, Ono M, Yuasa T, Yoshino T, Fukumoto M, et al. Modulation of immunoglobulin (Ig)E-mediated systemic anaphylaxis by low-affinity Fc receptors for IgG. J Exp Med. 1999;189:1573-9 pubmed
    ..Mice deficient in the inhibitory receptor for IgG, FcgammaRIIB, display enhanced IgE-mediated anaphylactic responses, whereas mice deficient in an IgG activation receptor, ..
  64. Junttila T, Parsons K, Olsson C, Lu Y, Xin Y, Theriault J, et al. Superior in vivo efficacy of afucosylated trastuzumab in the treatment of HER2-amplified breast cancer. Cancer Res. 2010;70:4481-9 pubmed publisher
    ..Our results show that afucosylated trastuzumab has superior efficacy in treating in vivo models of HER2-amplified breast cancer and support the development of effector function-enhanced antibodies for solid tumor therapy. ..
  65. Gavin A, Barnes N, Dijstelbloem H, Hogarth P. Identification of the mouse IgG3 receptor: implications for antibody effector function at the interface between innate and adaptive immunity. J Immunol. 1998;160:20-3 pubmed
  66. Clynes R, Maizes J, Guinamard R, Ono M, Takai T, Ravetch J. Modulation of immune complex-induced inflammation in vivo by the coordinate expression of activation and inhibitory Fc receptors. J Exp Med. 1999;189:179-85 pubmed
    ..In vitro, this pathway can be interrupted by coligation to FcgammaRIIB, an IgG Fc receptor containing an inhibitory motif (ITIM)...
  67. Karlsson M, Getahun A, Heyman B. FcgammaRIIB in IgG-mediated suppression of antibody responses: different impact in vivo and in vitro. J Immunol. 2001;167:5558-64 pubmed
    ..suppression of primary Ab responses to SRBC in mice lacking the known FcRs for IgG (FcgammaRI, FcgammaIII, and FcgammaRIIB or the neonatal FcR)...
  68. Sharp P, Martin Ramirez J, Boross P, Mangsbo S, Reynolds J, Moss J, et al. Increased incidence of anti-GBM disease in Fcgamma receptor 2b deficient mice, but not mice with conditional deletion of Fcgr2b on either B cells or myeloid cells alone. Mol Immunol. 2012;50:49-56 pubmed publisher
    Fcgamma receptor 2b (Fcgr2b) is the only inhibitory Fcgamma receptor in both humans and mice, and is implicated in both antibody production and effector responses to antibody complexes...
  69. Qiu W, de Bruin D, Brownstein B, Pearse R, Ravetch J. Organization of the human and mouse low-affinity Fc gamma R genes: duplication and recombination. Science. 1990;248:732-5 pubmed
    Receptors for immunoglobulin G immune complexes (Fc gamma RII and Fc gamma RIII) are expressed on most hematopoietic cells and show much structural and functional diversity...