Gene Symbol: Fcer2a
Description: Fc receptor, IgE, low affinity II, alpha polypeptide
Alias: CD23, Fce2, Fcer2, Ly-42, low affinity immunoglobulin epsilon Fc receptor, FC epsilon RII, fc-epsilon-RII, low-affinity IgE receptor, lymphocyte IgE receptor
Species: mouse
Products:     Fcer2a

Top Publications

  1. Lewis G, Rapsomaniki E, Bouriez T, Crockford T, Ferry H, Rigby R, et al. Hyper IgE in New Zealand black mice due to a dominant-negative CD23 mutation. Immunogenetics. 2004;56:564-71 pubmed
    ..The IgE response is in turn regulated by the B-cell co-receptor CD23, and CD23-deficient mice show exaggerated IgE responses and airway hyper-responsiveness...
  2. Getahun A, Hjelm F, Heyman B. IgE enhances antibody and T cell responses in vivo via CD23+ B cells. J Immunol. 2005;175:1473-82 pubmed
    ..IgE-mediated feedback enhancement requires the low affinity receptor for IgE, CD23. One possible mechanism is that B cells take up IgE-Ag via CD23 and efficiently present Ag to Th cells, resulting ..
  3. Mathews J, Gibb D, Chen B, Scherle P, Conrad D. CD23 Sheddase A disintegrin and metalloproteinase 10 (ADAM10) is also required for CD23 sorting into B cell-derived exosomes. J Biol Chem. 2010;285:37531-41 pubmed publisher
    The low affinity receptor for IgE, CD23, is the natural regulator of IgE synthesis, and understanding both the synthesis and the catabolism of CD23 are, thus, important issues...
  4. Carlsson F, Hjelm F, Conrad D, Heyman B. IgE enhances specific antibody and T-cell responses in mice overexpressing CD23. Scand J Immunol. 2007;66:261-70 pubmed
    ..Both effects are dependent on the low-affinity receptor for IgE (CD23) and the underlying mechanism is thought to be increased antigen presentation following uptake of IgE/antigen ..
  5. Mancardi D, Iannascoli B, Hoos S, England P, Daëron M, Bruhns P. FcgammaRIV is a mouse IgE receptor that resembles macrophage FcepsilonRI in humans and promotes IgE-induced lung inflammation. J Clin Invest. 2008;118:3738-50 pubmed publisher
    ..We therefore suggest that a similar cooperation may occur between mast cells and hFceRI-expressing lung cells in human allergic asthma. ..
  6. Hjelm F, Karlsson M, Heyman B. A novel B cell-mediated transport of IgE-immune complexes to the follicle of the spleen. J Immunol. 2008;180:6604-10 pubmed
    ..The IgE effect is completely dependent on the low-affinity receptor for IgE, CD23, whereas the IgG2a effect depends on activating FcgammaRs...
  7. Gustavsson S, Wernersson S, Heyman B. Restoration of the antibody response to IgE/antigen complexes in CD23-deficient mice by CD23+ spleen or bone marrow cells. J Immunol. 2000;164:3990-5 pubmed
    ..The enhancement is mediated via the low-affinity receptor for IgE (FcepsilonRII or CD23), as shown by its complete absence in mice pretreated with mAbs specific for CD23 and in CD23-deficient mice...
  8. Fujiwara H, Kikutani H, Suematsu S, Naka T, Yoshida K, Tanaka T, et al. The absence of IgE antibody-mediated augmentation of immune responses in CD23-deficient mice. Proc Natl Acad Sci U S A. 1994;91:6835-9 pubmed
    The CD23 antigen, a low-affinity receptor for IgE (Fc epsilon RII), is a type II membrane-bound glycoprotein expressed on various cells, particularly mature B cells...
  9. Dierks S, Bartlett W, Edmeades R, Gould H, Rao M, Conrad D. The oligomeric nature of the murine Fc epsilon RII/CD23. Implications for function. J Immunol. 1993;150:2372-82 pubmed
    The low affinity receptor for IgE (Fc epsilon RII/CD23) is a type II integral membrane protein with an extracellular C-terminal region homologous to C-type animal lectins...

More Information


  1. Ford J, Kilmon M, Haas K, Shelburne A, Chan Li Y, Conrad D. In vivo murine CD23 destabilization enhances CD23 shedding and IgE synthesis. Cell Immunol. 2006;243:107-17 pubmed
    To investigate the effects of in vivo CD23 destabilization on CD23 shedding and IgE production, an anti-CD23 stalk monoclonal (19G5), previously shown to enhance proteolysis of CD23 in vitro, was utilized...
  2. Yu P, Kosco Vilbois M, Richards M, Kohler G, Lamers M. Negative feedback regulation of IgE synthesis by murine CD23. Nature. 1994;369:753-6 pubmed
    ..It is increased during parasitic infestations and mediates allergy. CD23, the low-affinity receptor for IgE (Fc epsilon RII), has been proposed as an important regulator of IgE synthesis...
  3. Ford J, Sturgill J, Conrad D. 129/SvJ mice have mutated CD23 and hyper IgE. Cell Immunol. 2009;254:124-34 pubmed publisher
    CD23, the low affinity IgE receptor, is hypothesized to function as a negative regulator of IgE production...
  4. Gollnick S, Trounstine M, Yamashita L, Kehry M, Moore K. Isolation, characterization, and expression of cDNA clones encoding the mouse Fc receptor for IgE (Fc epsilon RII)1. J Immunol. 1990;144:1974-82 pubmed
    We have isolated cDNA clones encoding a mouse low affinity receptor for IgE (Fc epsilon RII) from a cDNA library of BALB/c splenic B cells activated with LPS and IL-4. The 2...
  5. Nunez R, Lynch R. CD23 isoforms in murine T and B lymphocytes. Pathobiology. 1993;61:128-37 pubmed
    ..of the present studies was to seek biochemical evidence for the production of the low affinity IgE Fc receptor (CD23) by murine T cells...
  6. Richards M, Katz D. Regulation of the murine Fc epsilon RII (CD23) gene. Functional characterization of an IL-4 enhancer element. J Immunol. 1994;152:3453-66 pubmed
    The murine B cell IgE receptor (Fc epsilon RII, CD23) has been implicated in various functions including IgE regulation, Ag presentation, and B cell differentiation/activation...
  7. Jönsson F, Mancardi D, Zhao W, Kita Y, Iannascoli B, Khun H, et al. Human Fc?RIIA induces anaphylactic and allergic reactions. Blood. 2012;119:2533-44 pubmed publisher
    ..Supporting these findings, human mast cells, monocytes and neutrophils produced anaphylactogenic mediators after Fc?RIIA engagement. IgG and Fc?RIIA may therefore contribute to allergic and anaphylactic reactions in humans. ..
  8. Conrad D, Kozak C, Vernachio J, Squire C, Rao M, Eicher E. Chromosomal location and isoform analysis of mouse Fc epsilon RII/CD23. Mol Immunol. 1993;30:27-33 pubmed
    The gene for the mouse low affinity receptor for IgE (Fc epsilon RII, also known as CD23) was mapped on Chromosome (Chr) 8 proximal to Plat...
  9. Stief A, Texido G, Sansig G, Eibel H, Le Gros G, van Der Putten H. Mice deficient in CD23 reveal its modulatory role in IgE production but no role in T and B cell development. J Immunol. 1994;152:3378-90 pubmed
    To assess roles of CD23 in lymphocyte development and immune function in vivo, CD23-deficient mice (CD23-/-) were generated...
  10. Dasic G, Juillard P, Graber P, Herren S, Angell T, Knowles R, et al. Critical role of CD23 in allergen-induced bronchoconstriction in a murine model of allergic asthma. Eur J Immunol. 1999;29:2957-67 pubmed
    b>CD23-deficient and anti-CD23 monoclonal antibody-treated mice were used to investigate the role of the low-affinity receptor for IgE (CD23) in allergic airway inflammation and airway hyperresponsiveness (AHR)...
  11. Obayashi K, Doi T, Koyasu S. Dendritic cells suppress IgE production in B cells. Int Immunol. 2007;19:217-26 pubmed
    ..On the other hand, LPS-induced mature BMDCs lose the ability to inhibit IgE CSR but still suppress IgE production by decreasing IgE protein expression. These results indicate novel regulatory functions of DCs on IgE production. ..
  12. Matsuoka K, Taya C, Kubo S, Toyama Sorimachi N, Kitamura F, Ra C, et al. Establishment of antigen-specific IgE transgenic mice to study pathological and immunobiological roles of IgE in vivo. Int Immunol. 1999;11:987-94 pubmed
    ..The expression of low-affinity IgE receptor FcepsilonRII (CD23) on splenic B cells was also 6-8 times higher in the transgenic mice...
  13. Mukai K, Matsuoka K, Taya C, Suzuki H, Yokozeki H, Nishioka K, et al. Basophils play a critical role in the development of IgE-mediated chronic allergic inflammation independently of T cells and mast cells. Immunity. 2005;23:191-202 pubmed
    ..These findings indicate a novel mechanism of development of chronic allergic inflammation that is induced by basophils through the interaction of antigen, IgE, and FcRI. ..
  14. Soilleux E, Barten R, Trowsdale J. DC-SIGN; a related gene, DC-SIGNR; and CD23 form a cluster on 19p13. J Immunol. 2000;165:2937-42 pubmed
    ..Here we report the genomic organization of DC-SIGN and map it to chromosome 19p13 adjacent to the C-type lectin CD23 (FcepsilonRII)...
  15. Kleinau S, Martinsson P, Gustavsson S, Heyman B. Importance of CD23 for collagen-induced arthritis: delayed onset and reduced severity in CD23-deficient mice. J Immunol. 1999;162:4266-70 pubmed
    Increased expression of the low affinity receptor for IgE, FcepsilonRII/CD23 has been observed in rheumatoid arthritis...
  16. Texido G, Jacobs H, Meiering M, Kuhn R, Roes J, Muller W, et al. Somatic hypermutation occurs in B cells of terminal deoxynucleotidyl transferase-, CD23-, interleukin-4-, IgD- and CD30-deficient mouse mutants. Eur J Immunol. 1996;26:1966-9 pubmed
  17. Kong Y, Kishihara K, Sumichika H, Nakamura T, Kaneko M, Nomoto K. Differential requirements of CD45 for lymphocyte development and function. Eur J Immunol. 1995;25:3431-6 pubmed
    ..However, CD4+ T helper function was severely diminished in CD45 exon 6-deficient mice, suggesting that the requirements of CD45 molecules in antigen-specific response and development are different between T and B lymphocytes. ..
  18. Riffo Vasquez Y, Spina D, Thomas M, Gilbey T, Kemeny D, Page C. The role of CD23 on allergen-induced IgE levels, pulmonary eosinophilia and bronchial hyperresponsiveness in mice. Clin Exp Allergy. 2000;30:728-38 pubmed
    ..The low affinity IgE receptor, CD23, is known to act as a negative regulator of IgE production and we have used knockout mice ..
  19. Hannani D, Locher C, Yamazaki T, Colin Minard V, Vetizou M, Aymeric L, et al. Contribution of humoral immune responses to the antitumor effects mediated by anthracyclines. Cell Death Differ. 2014;21:50-8 pubmed publisher
  20. Perrigoue J, Zaph C, Guild K, Du Y, Artis D. IL-31-IL-31R interactions limit the magnitude of Th2 cytokine-dependent immunity and inflammation following intestinal helminth infection. J Immunol. 2009;182:6088-94 pubmed publisher
    ..Collectively, these data provide the first evidence of a function for IL-31-IL-31R interactions in limiting the magnitude of type 2 inflammatory responses within the intestine. ..
  21. Lecoanet Henchoz S, Plater Zyberk C, Graber P, Gretener D, Aubry J, Conrad D, et al. Mouse CD23 regulates monocyte activation through an interaction with the adhesion molecule CD11b/CD18. Eur J Immunol. 1997;27:2290-4 pubmed
    b>CD23 is expressed on a variety of hemopoietic cells. Recently, we have reported that blocking CD23 interactions in a murine model of arthritis resulted in a marked improvement of disease severity...
  22. Gibb D, El Shikh M, Kang D, Rowe W, El Sayed R, Cichy J, et al. ADAM10 is essential for Notch2-dependent marginal zone B cell development and CD23 cleavage in vivo. J Exp Med. 2010;207:623-35 pubmed publisher
    ..Additionally, cleavage of the low affinity IgE receptor, CD23, was profoundly impaired, but subsequent experiments demonstrated that ADAM10 regulates CD23 ..
  23. Yu L, Yang P, Berin M, Di Leo V, Conrad D, McKay D, et al. Enhanced transepithelial antigen transport in intestine of allergic mice is mediated by IgE/CD23 and regulated by interleukin-4. Gastroenterology. 2001;121:370-81 pubmed
    ..the essential components mediating antigen uptake in mice genetically deficient for interleukin (IL)-4 or CD23. Mice were actively or passively sensitized to horseradish peroxidase (HRP)...
  24. Pongratz G, McAlees J, Conrad D, Erbe R, Haas K, Sanders V. The level of IgE produced by a B cell is regulated by norepinephrine in a p38 MAPK- and CD23-dependent manner. J Immunol. 2006;177:2926-38 pubmed
    ..Also, CD23 transcription was increased in a p38 MAPK-dependent manner and resulted in an increased level of soluble CD23 (..
  25. Montagnac G, Yu L, Bevilacqua C, Heyman M, Conrad D, Perdue M, et al. Differential role for CD23 splice forms in apical to basolateral transcytosis of IgE/allergen complexes. Traffic. 2005;6:230-42 pubmed
    The low affinity receptor for IgE (CD23) was recently implicated in the trans-epithelial transport of IgE-allergen complexes from the luminal side of enterocytes in animal models for intestinal allergy...
  26. Yu L, Montagnac G, Yang P, Conrad D, Benmerah A, Perdue M. Intestinal epithelial CD23 mediates enhanced antigen transport in allergy: evidence for novel splice forms. Am J Physiol Gastrointest Liver Physiol. 2003;285:G223-34 pubmed
    ..transport in the intestine of allergic rodents associated with elevated expression of the low-affinity IgE receptor CD23 on enterocytes...
  27. Gerth A, Lin L, Peng S. T-bet regulates T-independent IgG2a class switching. Int Immunol. 2003;15:937-44 pubmed
    ..T-bet-deficient B cells therefore represent a novel paradigm by which to investigate the regulation of humoral immune responses. ..
  28. Holmes K, Morse H. Murine hematopoietic cell surface antigen expression. Immunol Today. 1988;9:344-50 pubmed
  29. Hunt C, Parsian A, Kozak C. Genetic mapping of mouse heat shock protein genes Hsc4a to chromosome 11 and Hsc74 to chromosome 18 and two Hsc74 pseudogenes to chromosomes X and 8. Genomics. 1999;56:358-60 pubmed
  30. Mulero Marchese R, Blank K, Sieck T. Strain-dependent migration of lymphocytes to the vaginal mucosa after peripheral immunization. Immunogenetics. 1999;49:973-80 pubmed
    ..immunization included the intercellular adhesion molecule-1 (ICAM-1), the Icam-1 related sequence 1, and the Fc epsilon RII (P<0.01)...
  31. Feng P, Zhao H, Chai J, Huang L, Wang H. Expression and secretion of TNF-? in mouse taste buds: a novel function of a specific subset of type II taste cells. PLoS ONE. 2012;7:e43140 pubmed publisher
    ..The taste-cell-produced TNF-? may contribute to local immune surveillance, as well as regulate taste sensation under normal and pathological conditions. ..
  32. Roes J, Rajewsky K. Immunoglobulin D (IgD)-deficient mice reveal an auxiliary receptor function for IgD in antigen-mediated recruitment of B cells. J Exp Med. 1993;177:45-55 pubmed
    ..and CD5-positive (B1) B cells are present in normal numbers, and the expression of the surface markers CD22 and CD23 in the compartment of conventional B cells indicates acquisition of a mature phenotype...
  33. Kondo H, Ichikawa Y, Nakamura K, Tsuchiya S. Cloning of cDNAs for new subtypes of murine low-affinity Fc receptor for IgE (Fc epsilon RII/CD23). Int Arch Allergy Immunol. 1994;105:38-48 pubmed
    ..A new cDNA subtype for murine Fc epsilon RII that has amino acid homology to the human subtype b at the amino terminus was cloned by polymerase chain ..
  34. Miller H, Bluth M, Chice S, Durkin H, Auci D. IFN-alpha-mediated suppression of low-affinity FC(epsilon) receptors on Peyer's patch lymphocytes and augmentation of soluble CD23: implications for IgE responses. J Leukoc Biol. 1996;59:725-7 pubmed
    ..of interleukin (IL)-6 or interferon-alpha (IFN-alpha) to regulate expression of low-affinity Fc(epsilon) receptor (CD23) and serum levels of CD23 was studied in benzylpenicilloyl-keyhole limpet hemocyanin-sensitized BALB/c mice at the ..
  35. Montagnac G, Molla Herman A, Bouchet J, Yu L, Conrad D, Perdue M, et al. Intracellular trafficking of CD23: differential regulation in humans and mice by both extracellular and intracellular exons. J Immunol. 2005;174:5562-72 pubmed
    ..These data suggested that regulation of endocytosis plays a central role in CD23 functions and drove us to systematically compare the intracellular trafficking properties of human and murine CD23 ..
  36. Apasov S, Blackburn M, Kellems R, Smith P, Sitkovsky M. Adenosine deaminase deficiency increases thymic apoptosis and causes defective T cell receptor signaling. J Clin Invest. 2001;108:131-41 pubmed
    ..Experiments with thymocytes ex vivo confirmed that ADA deficiency reduces tyrosine phosphorylation of TCR-associated signaling molecules and blocks TCR-triggered calcium increases. ..
  37. Haczku A, Takeda K, Hamelmann E, Loader J, Joetham A, Redai I, et al. CD23 exhibits negative regulatory effects on allergic sensitization and airway hyperresponsiveness. Am J Respir Crit Care Med. 2000;161:952-60 pubmed
    The effects of an anti-CD23 monoclonal antibody (B3B4) in CD23-deficient and CD23-overexpressing mice were compared in a murine model of allergic sensitization...
  38. Richards M, Katz D. Analysis of the promoter elements necessary for IL-4 and anti-CD40 antibody induction of murine Fc epsilon RII (CD23): comparison with the germline epsilon promoter. J Immunol. 1997;158:263-72 pubmed
    IL-4 and CD40 ligand stimulate transcription of CD23 (Fc epsilonRII) in B cells and are necessary for the expression of germline epsilon mRNA and production of IgE...
  39. Mancardi D, Jönsson F, Iannascoli B, Khun H, Van Rooijen N, Huerre M, et al. Cutting Edge: The murine high-affinity IgG receptor Fc?RIV is sufficient for autoantibody-induced arthritis. J Immunol. 2011;186:1899-903 pubmed publisher
  40. Kilmon M, Mayer R, Marshall L, Conrad D. Metalloprotease inhibitor-mediated inhibition of mouse immunoglobulin production. Immunology. 2001;102:281-8 pubmed
    High levels of membrane CD23 have been shown to decrease immunoglobulin E (IgE). CD23 is a very labile molecule and is cleaved from the cell surface by an unknown metalloprotease...
  41. Albanesi M, Mancardi D, Macdonald L, Iannascoli B, Zitvogel L, Murphy A, et al. Cutting edge: Fc?RIII (CD16) and Fc?RI (CD64) are responsible for anti-glycoprotein 75 monoclonal antibody TA99 therapy for experimental metastatic B16 melanoma. J Immunol. 2012;189:5513-7 pubmed publisher
    ..Our finding that mouse Fc?RIII contributes to Ab-induced tumor reduction correlates with clinical data on its human functional equivalent human Fc?RIIIA (CD16A). ..
  42. Yang R, Huang Q, Xu A, McLenithan J, Eisen J, Shuldiner A, et al. Comparative studies of resistin expression and phylogenomics in human and mouse. Biochem Biophys Res Commun. 2003;310:927-35 pubmed
    ..The high expression of resistin in human leukemia cells suggests a hitherto unidentified biological function of resistin in leukocytes. ..
  43. Filie J, Burbelo P, Kozak C. Genetic mapping of the alpha 1 and alpha 2 (IV) collagen genes to mouse chromosome 8. Mamm Genome. 1995;6:487 pubmed
  44. Lyu M, Kozak C. Genetic mapping of the amphotropic murine leukemia virus receptor on mouse chromosome 8. Virology. 1994;204:868-9 pubmed
    ..Analysis of the progeny of two interspecies genetic crosses was used to establish the genetic map location of the mouse gene encoding this receptor, Ram1, within the proximal region of chromosome 8. ..
  45. Padlan E, Helm B. Modeling of the lectin-homology domains of the human and murine low-affinity Fc epsilon receptor (Fc epsilon RII/CD23). Receptor. 1993;3:325-41 pubmed
    Models of the lectin-homology domains of the human and murine low-affinity receptors for IgE (Fc epsilon RII/CD23) were built on the basis of sequence similarity with rat mannose-binding protein, the structure of which is known...
  46. Park C, Takahara K, Umemoto E, Yashima Y, Matsubara K, Matsuda Y, et al. Five mouse homologues of the human dendritic cell C-type lectin, DC-SIGN. Int Immunol. 2001;13:1283-90 pubmed
    ..2-1.3. However, like human DC-SIGN, only the mouse DC-SIGN gene is closely juxtaposed to the CD23 gene, while the other four SIGNR genes are located close to each other in a neighboring region...
  47. Erlandsson L, Licence S, Gaspal F, Lane P, Corcoran A, Martensson I. Both the pre-BCR and the IL-7Ralpha are essential for expansion at the pre-BII cell stage in vivo. Eur J Immunol. 2005;35:1969-76 pubmed
    ..As a consequence of the absence of both receptors, the peripheral B cell pool is severely depleted, resulting in atypical splenic B cell structures and reduced serum Ig levels. ..
  48. Xue H, Jing X, Bollenbacher Reilley J, Zhao D, Haring J, Yang B, et al. Targeting the GA binding protein beta1L isoform does not perturb lymphocyte development and function. Mol Cell Biol. 2008;28:4300-9 pubmed publisher
    ..Our findings argue against such a possibility and rather suggest that GABPbeta1S has a critical role in maintaining the transcriptional activity of the GABPalpha/beta complex. ..
  49. Cheng L, Wang Z, Locksley R. Murine B cells regulate serum IgE levels in a CD23-dependent manner. J Immunol. 2010;185:5040-7 pubmed publisher
    ..B cells captured IgE by direct binding to the low-affinity IgE receptor, CD23. These data indicate a mechanism regulating serum IgE and additionally clarify the role of CD23 in this process.
  50. Henningsson F, Ding Z, Dahlin J, Linkevicius M, Carlsson F, Grönvik K, et al. IgE-mediated enhancement of CD4+ T cell responses in mice requires antigen presentation by CD11c+ cells and not by B cells. PLoS ONE. 2011;6:e21760 pubmed publisher
    ..The effect is dependent on the low affinity receptor for IgE, CD23, and the receptor must be expressed on B cells...
  51. Kretschmer K, Jungebloud A, Stopkowicz J, Kleinke T, Hoffmann R, Weiss S. The selection of marginal zone B cells differs from that of B-1a cells. J Immunol. 2003;171:6495-501 pubmed
    ..Thus, our data demonstrate that despite common functional properties, MZ B and B-1a cells exhibit striking differences in their selection and/or maintenance requirements. ..
  52. García Serna A, Alcaraz García M, Ruiz Lafuente N, Sebastián Ruiz S, Martínez C, Moya Quiles M, et al. Dock10 regulates CD23 expression and sustains B-cell lymphopoiesis in secondary lymphoid tissue. Immunobiology. 2016;221:1343-1350 pubmed publisher
    ..b>CD23, the low-affinity receptor for immunoglobulin E, was overexpressed on follicular B cells from KO mice, suggesting ..
  53. Bettler B, Hofstetter H, Rao M, Yokoyama W, Kilchherr F, Conrad D. Molecular structure and expression of the murine lymphocyte low-affinity receptor for IgE (Fc epsilon RII). Proc Natl Acad Sci U S A. 1989;86:7566-70 pubmed
    The cDNA encoding the murine low-affinity receptor for IgE (Fc epsilon RII) has been isolated from a cDNA library prepared from B cells activated with lipopolysaccharide and interleukin 4...
  54. Lübben W, Turqueti Neves A, Okhrimenko A, Stöberl C, Schmidt V, Pfeffer K, et al. IgE knock-in mice suggest a role for high levels of IgE in basophil-mediated active systemic anaphylaxis. Eur J Immunol. 2013;43:1231-42 pubmed publisher
    ..Therefore, we propose that an enhanced, antigen-specific, polyclonal IgE response, as is the case in allergic patients, is probably the most efficient way to sensitize basophils to contribute to systemic anaphylaxis in vivo. ..
  55. Debnath I, Roundy K, Weis J, Weis J. Analysis of the regulatory role of BAFF in controlling the expression of CD21 and CD23. Mol Immunol. 2007;44:2388-99 pubmed
    ..Induced expression of CD23 and CD21 is also coincident with the T1 to T2 maturation stage...
  56. Nigro E, Brini A, Soprana E, Ambrosi A, Dombrowicz D, Siccardi A, et al. Antitumor IgE adjuvanticity: key role of Fc epsilon RI. J Immunol. 2009;183:4530-6 pubmed publisher
    ..However, the protective effect was lost in Fc(epsilon)RIalpha(-/-) (but not in CD23(-/-)) knockout mice, showing the IgE-Fc(epsilo)nRI interaction to be essential...
  57. Taube C, Wei X, Swasey C, Joetham A, Zarini S, Lively T, et al. Mast cells, Fc epsilon RI, and IL-13 are required for development of airway hyperresponsiveness after aerosolized allergen exposure in the absence of adjuvant. J Immunol. 2004;172:6398-406 pubmed
    ..These results show that FcepsilonRI is important for the development of AHR after an aerosolized allergen sensitization protocol and that this effect is mediated through FcepsilonRI on mast cells and production of IL-13 in the lung. ..
  58. Pupovac A, Geraghty N, Watson D, Sluyter R. Activation of the P2X7 receptor induces the rapid shedding of CD23 from human and murine B cells. Immunol Cell Biol. 2015;93:77-85 pubmed publisher
    ..5'-triphosphate (ATP), induces the shedding of cell surface molecules including the low-affinity IgE receptor, CD23, from human leukocytes...
  59. Wang T, Maamary J, Tan G, Bournazos S, Davis C, Krammer F, et al. Anti-HA Glycoforms Drive B Cell Affinity Selection and Determine Influenza Vaccine Efficacy. Cell. 2015;162:160-9 pubmed publisher
    ..We show that sFcs drive BCR affinity selection by binding the Type-II FcR CD23, thus upregulating the inhibitory FcγRIIB on activated B cells...
  60. Richards M, Katz D, Liu F. Complete genomic sequence of the murine low affinity Fc receptor for IgE. Demonstration of alternative transcripts and conserved sequence elements. J Immunol. 1991;147:1067-74 pubmed
    The complete sequence of the murine low affinity Fc receptor for IgE (Fc epsilon RII), including the 5' and 3' flanking sequences, is reported. The murine Fc epsilon RII gene spans 12.9 kb and includes 12 exons surrounding 11 introns...
  61. Dahlin J, Ivarsson M, Heyman B, Hallgren J. IgE immune complexes stimulate an increase in lung mast cell progenitors in a mouse model of allergic airway inflammation. PLoS ONE. 2011;6:e20261 pubmed publisher
    ..of lung mast cell progenitors by IgE immune complex challenge was lost in FcR? deficient mice but not in CD23 deficient mice...
  62. Hagen M, Sacco R, Sandor M, Best C, Nambu M, Lynch R. The Fc epsilon RII/CD23 gene is actively transcribed during all stages of murine B-lymphocyte development. Mol Immunol. 1995;32:1245-57 pubmed
    It is generally accepted that the expression of Fc epsilon RII/CD23 on the surface of the B-lineage cells is restricted to the stage of the resting, mature (sIgM+/sIgD+) B-lymphocyte...