Gene Symbol: Fat4
Description: FAT atypical cadherin 4
Alias: 6030410K14Rik, 9430004M15, protocadherin Fat 4, FAT tumor suppressor homolog 4, fat-like cadherin protein FAT-J
Species: mouse
Products:     Fat4

Top Publications

  1. Saburi S, Hester I, Fischer E, Pontoglio M, Eremina V, Gessler M, et al. Loss of Fat4 disrupts PCP signaling and oriented cell division and leads to cystic kidney disease. Nat Genet. 2008;40:1010-5 pubmed publisher
    ..In Drosophila, Fat represses fj transcription, and Ds represses Fat activity in PCP. Here we show that Fat4 is an essential gene that has a key role in vertebrate PCP...
  2. Rock R, Schrauth S, Gessler M. Expression of mouse dchs1, fjx1, and fat-j suggests conservation of the planar cell polarity pathway identified in Drosophila. Dev Dyn. 2005;234:747-55 pubmed
    ..These data are compatible with a conservation and sub-functionalization of the Drosophila Ds, Fj, and Fat signaling in higher vertebrates. ..
  3. Pujol F, Hodgson T, Martínez Corral I, Prats A, Devenport D, Takeichi M, et al. Dachsous1-Fat4 Signaling Controls Endothelial Cell Polarization During Lymphatic Valve Morphogenesis-Brief Report. Arterioscler Thromb Vasc Biol. 2017;37:1732-1735 pubmed publisher
    The purpose of this study was to investigate the role of Fat4 and Dachsous1 signaling in the lymphatic vasculature. Phenotypic analysis of the lymphatic vasculature was performed in mice lacking functional Fat4 or Dachsous1...
  4. Ragni C, Diguet N, Le Garrec J, Novotova M, Resende T, Pop S, et al. Amotl1 mediates sequestration of the Hippo effector Yap1 downstream of Fat4 to restrict heart growth. Nat Commun. 2017;8:14582 pubmed publisher
    ..in flies the atypical cadherin Fat is an upstream regulator of Hippo signalling, the closest mammalian homologue, Fat4, has been shown to regulate tissue polarity rather than growth...
  5. Ohmori T, Tanigawa S, Kaku Y, Fujimura S, Nishinakamura R. Sall1 in renal stromal progenitors non-cell autonomously restricts the excessive expansion of nephron progenitors. Sci Rep. 2015;5:15676 pubmed publisher
    ..In contrast, the expression of Fat4, which restricts nephron progenitor expansion, was reduced mildly...
  6. Mao Y, Francis West P, Irvine K. Fat4/Dchs1 signaling between stromal and cap mesenchyme cells influences nephrogenesis and ureteric bud branching. Development. 2015;142:2574-85 pubmed publisher
    ..The protocadherin Fat4 influences signaling from stromal to cap mesenchyme cells to regulate their differentiation into nephrons...
  7. Bagherie Lachidan M, Reginensi A, Pan Q, Zaveri H, Scott D, Blencowe B, et al. Stromal Fat4 acts non-autonomously with Dchs1/2 to restrict the nephron progenitor pool. Development. 2015;142:2564-73 pubmed publisher
    ..Loss of either the atypical cadherin FAT4 or its ligand Dachsous 1 (DCHS1) results in expansion of the mesenchymal nephron progenitor pool, called the ..
  8. Sugiyama Y, Shelley E, Badouel C, McNeill H, McAvoy J. Atypical Cadherin Fat1 Is Required for Lens Epithelial Cell Polarity and Proliferation but Not for Fiber Differentiation. Invest Ophthalmol Vis Sci. 2015;56:4099-107 pubmed publisher
    ..To account for the partial penetrance of the Fat1 phenotype, involvement of Fat4 in eye development was assessed. Lens phenotypes in Fat1 and 4 knockouts were also examined...
  9. Tsukasaki Y, Miyazaki N, Matsumoto A, Nagae S, Yonemura S, Tanoue T, et al. Giant cadherins Fat and Dachsous self-bend to organize properly spaced intercellular junctions. Proc Natl Acad Sci U S A. 2014;111:16011-6 pubmed publisher
    ..Our electron-microscopic observations of mammalian Fat4 and Dachsous1 ectodomains, however, revealed that, although their N-terminal regions exhibit a linear configuration,..

More Information


  1. Zakaria S, Mao Y, Kuta A, de Sousa C, Gaufo G, McNeill H, et al. Regulation of neuronal migration by Dchs1-Fat4 planar cell polarity. Curr Biol. 2014;24:1620-1627 pubmed publisher
    ..Mutations in human FAT4 and DCHS1, key components of Fat-PCP signaling, cause Van Maldergem syndrome, characterized by severe neuronal ..
  2. Cappello S, Gray M, Badouel C, Lange S, Einsiedler M, Srour M, et al. Mutations in genes encoding the cadherin receptor-ligand pair DCHS1 and FAT4 disrupt cerebral cortical development. Nat Genet. 2013;45:1300-8 pubmed publisher
    ..Here we show that mutations in genes encoding the receptor-ligand cadherin pair DCHS1 and FAT4 lead to a recessive syndrome in humans that includes periventricular neuronal heterotopia...
  3. Xie Q, Yang Y, Huang J, Ninkovic J, Walcher T, Wolf L, et al. Pax6 interactions with chromatin and identification of its novel direct target genes in lens and forebrain. PLoS ONE. 2013;8:e54507 pubmed publisher
    ..5 wild type and Pax6?/? lens placodes that suggested Efnb2, Fat4, Has2, Nav1, and Trpm3 as novel Pax6-direct targets...
  4. Guettler S, LaRose J, Petsalaki E, Gish G, Scotter A, Pawson T, et al. Structural basis and sequence rules for substrate recognition by Tankyrase explain the basis for cherubism disease. Cell. 2011;147:1340-54 pubmed publisher
    ..Structural and sequence information allows us to also predict and validate other Tankyrase targets, including Disc1, Striatin, Fat4, RAD54, BCR, and MERIT40.
  5. Ishiuchi T, Misaki K, Yonemura S, Takeichi M, Tanoue T. Mammalian Fat and Dachsous cadherins regulate apical membrane organization in the embryonic cerebral cortex. J Cell Biol. 2009;185:959-67 pubmed publisher
    ..In this study, we present evidence that mammalian Fat4 and Dachsous1 cadherins regulate the apical plasma membrane organization in the embryonic cerebral cortex...
  6. Bossuyt W, Chen C, Chen Q, Sudol M, McNeill H, Pan D, et al. An evolutionary shift in the regulation of the Hippo pathway between mice and flies. Oncogene. 2014;33:1218-28 pubmed publisher
    ..Here we show that the mouse Fat4 cadherin, the ortholog of the Hippo pathway regulator Fat in Drosophila, does not apparently regulate the Hippo ..
  7. Saburi S, Hester I, GOODRICH L, McNeill H. Functional interactions between Fat family cadherins in tissue morphogenesis and planar polarity. Development. 2012;139:1806-20 pubmed publisher
    ..In mammals, four ft homologs have been identified (Fat1-4). Recently, we demonstrated that Fat4 plays a role in vertebrate planar polarity...
  8. Berndt A, Cario C, Silva K, Kennedy V, Harrison D, Paigen B, et al. Identification of fat4 and tsc22d1 as novel candidate genes for spontaneous pulmonary adenomas. Cancer Res. 2011;71:5779-91 pubmed publisher
    ..g., Pas1), others were unique to our study. In particular, Fat4 was influential in males and Tsc22d1 was influential in females...
  9. Badouel C, Zander M, Liscio N, Bagherie Lachidan M, Sopko R, Coyaud E, et al. Fat1 interacts with Fat4 to regulate neural tube closure, neural progenitor proliferation and apical constriction during mouse brain development. Development. 2015;142:2781-91 pubmed publisher
    ..Here, we examined the role of the atypical cadherins Fat1 and Fat4 in this process...
  10. Mao Y, Mulvaney J, Zakaria S, Yu T, Morgan K, Allen S, et al. Characterization of a Dchs1 mutant mouse reveals requirements for Dchs1-Fat4 signaling during mammalian development. Development. 2011;138:947-57 pubmed publisher
    ..Analysis of the phenotypes of Dchs1 mutant mice and comparisons with Fat4 mutant mice identify requirements for these genes in multiple organs, including the ear, kidney, skeleton, ..
  11. Mao Y, Kuta A, Crespo Enríquez I, Whiting D, Martin T, Mulvaney J, et al. Dchs1-Fat4 regulation of polarized cell behaviours during skeletal morphogenesis. Nat Commun. 2016;7:11469 pubmed publisher
    ..Here we show that the Dchs1-Fat4 planar cell polarity pathway controls cell orientation in the early skeletal condensation to define the shape and ..
  12. Kuta A, Mao Y, Martin T, Ferreira de Sousa C, Whiting D, Zakaria S, et al. Fat4-Dchs1 signalling controls cell proliferation in developing vertebrae. Development. 2016;143:2367-75 pubmed publisher
    The protocadherins Fat4 and Dchs1 act as a receptor-ligand pair to regulate many developmental processes in mice and humans, including development of the vertebrae...
  13. Klein A, Ferreira N, Ben Dor S, Duan J, Hardy J, Cox T, et al. Identification of Modifier Genes in a Mouse Model of Gaucher Disease. Cell Rep. 2016;16:2546-2553 pubmed publisher
    ..Our data identify putative modifier genes that may be involved in determining GD severity, which might help elucidate phenotypic variability between patients with similar GD mutations. ..
  14. Qi C, Zhu Y, Hu L, Zhu Y. Identification of Fat4 as a candidate tumor suppressor gene in breast cancers. Int J Cancer. 2009;124:793-8 pubmed publisher
    ..The expression of Fat4 gene, one member of the Fat family, in the deleted region was inactivated, which resulted from promoter methylation ..