Fas

Summary

Gene Symbol: Fas
Description: Fas (TNF receptor superfamily member 6)
Alias: AI196731, APO1, APT1, CD95, TNFR6, Tnfrsf6, lpr, tumor necrosis factor receptor superfamily member 6, FASLG receptor, Fas (TNF receptor superfamily member), Fas antigen, apo-1 antigen, apoptosis-mediating surface antigen FAS, lymphoproliferation
Species: mouse
Products:     Fas

Top Publications

  1. Lech M, Kulkarni O, Pfeiffer S, Savarese E, Krug A, Garlanda C, et al. Tir8/Sigirr prevents murine lupus by suppressing the immunostimulatory effects of lupus autoantigens. J Exp Med. 2008;205:1879-88 pubmed publisher
    ..role of Sigirr in the pathogenesis of systemic lupus erythematosus (SLE), we generated Sigirr-deficient C57BL/6-lpr/lpr mice...
  2. Hutcheson J, Scatizzi J, Siddiqui A, Haines G, Wu T, Li Q, et al. Combined deficiency of proapoptotic regulators Bim and Fas results in the early onset of systemic autoimmunity. Immunity. 2008;28:206-17 pubmed publisher
    Alterations in the stoichiometric balance between members of Bcl-2 and Fas apoptotic pathway could lead to the pathogenesis of systemic lupus erythematosus (SLE)...
  3. Letellier E, Kumar S, Sancho Martinez I, Krauth S, Funke Kaiser A, Laudenklos S, et al. CD95-ligand on peripheral myeloid cells activates Syk kinase to trigger their recruitment to the inflammatory site. Immunity. 2010;32:240-52 pubmed publisher
    ..Here, we showed that, in rodents and humans, injury to the spinal cord triggered surface expression of CD95 ligand (CD95L, FasL) on peripheral blood myeloid cells...
  4. Corsini N, Sancho Martinez I, Laudenklos S, Glagow D, Kumar S, Letellier E, et al. The death receptor CD95 activates adult neural stem cells for working memory formation and brain repair. Cell Stem Cell. 2009;5:178-90 pubmed publisher
    ..Here we show that in neural stem cells, stimulation of the "death receptor" CD95 does not trigger apoptosis but unexpectedly leads to increased stem cell survival and neuronal specification...
  5. Blair P, Chavez Rueda K, Evans J, Shlomchik M, Eddaoudi A, Isenberg D, et al. Selective targeting of B cells with agonistic anti-CD40 is an efficacious strategy for the generation of induced regulatory T2-like B cells and for the suppression of lupus in MRL/lpr mice. J Immunol. 2009;182:3492-3502 pubmed publisher
    ..Taken together, our results suggest a novel cellular approach for the amelioration of experimental lupus. ..
  6. Lamoureux J, Watson L, Cherrier M, Skog P, Nemazee D, Feeney A. Reduced receptor editing in lupus-prone MRL/lpr mice. J Exp Med. 2007;204:2853-64 pubmed
    ..We demonstrate that receptor editing is less efficient in the lupus-prone strain MRL/lpr. In an in vitro system, when receptor-editing signals are given to bone marrow immature B cells by antiidiotype ..
  7. Molano I, Mathenia J, Ruiz P, Gilkeson G, Zhang X. Decreased expression of Fli-1 in bone marrow-derived haematopoietic cells significantly affects disease development in Murphy Roths Large/lymphoproliferation (MRL/lpr) mice. Clin Exp Immunol. 2010;160:275-82 pubmed publisher
    ..Decreased expression of Fli-1 in heterozygous (Fli-1(+/-)) Murphy Roths Large (MRL)/lpr mice resulted in significantly lower kidney pathological scores and markedly increased survival...
  8. Dace D, Khan A, Stark J, Kelly J, Cross A, Apte R. Interleukin-10 overexpression promotes Fas-ligand-dependent chronic macrophage-mediated demyelinating polyneuropathy. PLoS ONE. 2009;4:e7121 pubmed publisher
    ..Macrophage-mediate demyelination is dependent on Fas-ligand (FasL)-mediated Schwann cell death...
  9. Nakamura T, Imai Y, Matsumoto T, Sato S, Takeuchi K, Igarashi K, et al. Estrogen prevents bone loss via estrogen receptor alpha and induction of Fas ligand in osteoclasts. Cell. 2007;130:811-23 pubmed
    ..Further, we show that estrogen induced apoptosis and upregulation of Fas ligand (FasL) expression in osteoclasts of the trabecular bones of WT but not ERalpha(DeltaOc/DeltaOc) mice...

More Information

Publications84

  1. Herlands R, Christensen S, Sweet R, Hershberg U, Shlomchik M. T cell-independent and toll-like receptor-dependent antigen-driven activation of autoreactive B cells. Immunity. 2008;29:249-60 pubmed publisher
    On the lupus-prone MRL-lpr/lpr (MRL-lpr) background, AM14 rheumatoid factor (RF) B cells are activated, differentiate into plasmablasts, and undergo somatic hypermutation outside of follicles...
  2. Mohamood A, Bargatze D, Xiao Z, Jie C, Yagita H, Ruben D, et al. Fas-mediated apoptosis regulates the composition of peripheral alphabeta T cell repertoire by constitutively purging out double negative T cells. PLoS ONE. 2008;3:e3465 pubmed publisher
    ..Despite extensive analysis, the basis of B220+DN T cell lymphoproliferation remains poorly understood...
  3. Lech M, Römmele C, Kulkarni O, Susanti H, Migliorini A, Garlanda C, et al. Lack of the long pentraxin PTX3 promotes autoimmune lung disease but not glomerulonephritis in murine systemic lupus erythematosus. PLoS ONE. 2011;6:e20118 pubmed publisher
    ..a potential immunoregulatory role of PTX3 in autoimmunity we crossed Ptx3-deficient mice with Fas-deficient (lpr) C57BL/6 (B6) mice with mild lupus-like autoimmunity...
  4. Noval Rivas M, Hazzan M, Weatherly K, Gaudray F, Salmon I, Braun M. NK cell regulation of CD4 T cell-mediated graft-versus-host disease. J Immunol. 2010;184:6790-8 pubmed publisher
    ..not involve perforin-mediated lytic activity of NK cells, but depended on T cell surface expression of a functional Fas molecule...
  5. Teichmann L, Ols M, Kashgarian M, Reizis B, Kaplan D, Shlomchik M. Dendritic cells in lupus are not required for activation of T and B cells but promote their expansion, resulting in tissue damage. Immunity. 2010;33:967-78 pubmed publisher
    ..By constitutively deleting DCs in MRL.Fas(lpr) mice, we show that they have complex roles in murine lupus...
  6. Krum S, Miranda Carboni G, Hauschka P, Carroll J, Lane T, Freedman L, et al. Estrogen protects bone by inducing Fas ligand in osteoblasts to regulate osteoclast survival. EMBO J. 2008;27:535-45 pubmed publisher
    ..Recent studies have suggested a role for Fas ligand (FasL) in estrogen-induced osteoclast apoptosis by an autocrine mechanism involving osteoclasts alone...
  7. Ishikawa T, Yamada H, Oyamada A, Goshima F, Nishiyama Y, Yoshikai Y. Protective role of Fas-FasL signaling in lethal infection with herpes simplex virus type 2 in mice. J Virol. 2009;83:11777-83 pubmed publisher
    ..In this study, we examined the roles of Fas-Fas ligand (FasL) signaling in lethal infection with HSV-2 by using mice with mutated Fas (lpr) or FasL (gld) in ..
  8. Zou Y, Chen T, Han M, Wang H, Yan W, Song G, et al. Increased killing of liver NK cells by Fas/Fas ligand and NKG2D/NKG2D ligand contributes to hepatocyte necrosis in virus-induced liver failure. J Immunol. 2010;184:466-75 pubmed publisher
    ..liver NK cells were cytotoxic to MHV-3-infected hepatocytes and this effect was markedly inhibited by anti-Fas ligand (FasL) plus anti-NKG2D mAbs...
  9. Hughes P, Belz G, Fortner K, Budd R, Strasser A, Bouillet P. Apoptosis regulators Fas and Bim cooperate in shutdown of chronic immune responses and prevention of autoimmunity. Immunity. 2008;28:197-205 pubmed publisher
    ..We examined mice lacking the gene encoding Bim (Bcl2l11) and with the inactivating lpr mutation in the gene encoding Fas (Fas), designated Bcl2l11(-/-)Fas(lpr/lpr) mice...
  10. Teichmann L, Kashgarian M, Weaver C, Roers A, Muller W, Shlomchik M. B cell-derived IL-10 does not regulate spontaneous systemic autoimmunity in MRL.Fas(lpr) mice. J Immunol. 2012;188:678-85 pubmed publisher
  11. Teachey D, Seif A, Brown V, Bruno M, Bunte R, Chang Y, et al. Targeting Notch signaling in autoimmune and lymphoproliferative disease. Blood. 2008;111:705-14 pubmed
    ..Inhibiting the Notch signaling pathway may thus present an effective, novel, and well-tolerated treatment for autoimmune and lymphoproliferative diseases. ..
  12. Yanaba K, Bouaziz J, Matsushita T, Tsubata T, Tedder T. The development and function of regulatory B cells expressing IL-10 (B10 cells) requires antigen receptor diversity and TLR signals. J Immunol. 2009;182:7459-72 pubmed publisher
    ..Thereby, both adaptive and innate signals regulate B10 cell development, maturation, CD5 expression, and competence for IL-10 production. ..
  13. Gómez Sintes R, Lucas J. NFAT/Fas signaling mediates the neuronal apoptosis and motor side effects of GSK-3 inhibition in a mouse model of lithium therapy. J Clin Invest. 2010;120:2432-45 pubmed publisher
    ..of nuclear factor of activated T cells c3/4 (NFATc3/4) transcription factors to the nucleus, leading to increased Fas ligand (FasL) levels and Fas activation...
  14. Jiang C, Loo W, Greenley E, Tung K, Erickson L. B cell maturation antigen deficiency exacerbates lymphoproliferation and autoimmunity in murine lupus. J Immunol. 2011;186:6136-47 pubmed publisher
    ..combined with the lpr mutation or the murine lupus susceptibility locus Nba2 causes dramatic B cell and PC lymphoproliferation, accelerated autoantibody production, and early lethality...
  15. Kleber S, Sancho Martinez I, Wiestler B, Beisel A, Gieffers C, Hill O, et al. Yes and PI3K bind CD95 to signal invasion of glioblastoma. Cancer Cell. 2008;13:235-48 pubmed publisher
    ..Tumor interaction with the surrounding brain tissue induces CD95 Ligand expression...
  16. Stranges P, Watson J, Cooper C, Choisy Rossi C, Stonebraker A, Beighton R, et al. Elimination of antigen-presenting cells and autoreactive T cells by Fas contributes to prevention of autoimmunity. Immunity. 2007;26:629-41 pubmed
    ..This paradigm is based on the extensive lymphoproliferation and systemic autoimmunity in mice and humans lacking Fas or its ligand...
  17. Couzinet A, Tamura K, Chen H, Nishimura K, Wang Z, Morishita Y, et al. A cell-type-specific requirement for IFN regulatory factor 5 (IRF5) in Fas-induced apoptosis. Proc Natl Acad Sci U S A. 2008;105:2556-61 pubmed publisher
    ..cell-type-specific role of IRF5 in promoting apoptosis upon signaling through the death receptor Fas (CD95/APO-1/TNFRSF6)...
  18. O Reilly L, Tai L, Lee L, Kruse E, Grabow S, Fairlie W, et al. Membrane-bound Fas ligand only is essential for Fas-induced apoptosis. Nature. 2009;461:659-63 pubmed publisher
    b>Fas ligand (FasL), an apoptosis-inducing member of the TNF cytokine family, and its receptor Fas are critical for the shutdown of chronic immune responses and prevention of autoimmunity...
  19. Nickerson K, Christensen S, Shupe J, Kashgarian M, Kim D, Elkon K, et al. TLR9 regulates TLR7- and MyD88-dependent autoantibody production and disease in a murine model of lupus. J Immunol. 2010;184:1840-8 pubmed publisher
    ..In this study, we characterize MRL/lpr lupus-prone mice genetically deficient in Tlr7, Tlr9, both Tlr7 and Tlr9, or Myd88 to test whether Tlr7 and Tlr9 ..
  20. Kyttaris V, Zhang Z, Kuchroo V, Oukka M, Tsokos G. Cutting edge: IL-23 receptor deficiency prevents the development of lupus nephritis in C57BL/6-lpr/lpr mice. J Immunol. 2010;184:4605-9 pubmed publisher
    ..In this study, we show that IL-23R-deficient lupus-prone C57BL/6-lpr/lpr mice display decreased numbers of CD3(+)CD4(-)CD8(-) cells and IL-17A-producing cells in the lymph nodes and ..
  21. Jiang C, Foley J, Clayton N, Kissling G, Jokinen M, Herbert R, et al. Abrogation of lupus nephritis in activation-induced deaminase-deficient MRL/lpr mice. J Immunol. 2007;178:7422-31 pubmed
    We generated MRL/lpr mice deficient in activation-induced deaminase (AID). Because AID is required for Ig hypermutation and class switch recombination, these mice lack hypermutated IgG Abs...
  22. Allam R, Pawar R, Kulkarni O, Hornung V, Hartmann G, Segerer S, et al. Viral 5'-triphosphate RNA and non-CpG DNA aggravate autoimmunity and lupus nephritis via distinct TLR-independent immune responses. Eur J Immunol. 2008;38:3487-98 pubmed publisher
    ..By contrast, transient exposure to non-CpG DNA exacerbate lupus nephritis in association with splenomegaly, lymphoproliferation, hypergammaglobulinaemia and increased B220(+)CD138(+) plasma cells...
  23. Rankin A, Guay H, Herber D, Bertino S, Duzanski T, Carrier Y, et al. IL-21 receptor is required for the systemic accumulation of activated B and T lymphocytes in MRL/MpJ-Fas(lpr/lpr)/J mice. J Immunol. 2012;188:1656-67 pubmed publisher
    MRL/MpJ-Fas(lpr/lpr)/J (MRL(lpr)) mice develop lupus-like disease manifestations in an IL-21-dependent manner...
  24. Zhang Z, Kyttaris V, Tsokos G. The role of IL-23/IL-17 axis in lupus nephritis. J Immunol. 2009;183:3160-9 pubmed publisher
    ..In this study, we show that double-negative T cells from MRL/lpr mice express high amounts of IL-17 and that as disease progressively worsens, the expression of IL-17 and of IL-23 ..
  25. Ait Azzouzene D, Kono D, Gonzalez Quintial R, McHeyzer Williams L, Lim M, Wickramarachchi D, et al. Deletion of IgG-switched autoreactive B cells and defects in Fas(lpr) lupus mice. J Immunol. 2010;185:1015-27 pubmed publisher
    ..This process was only partly dependent on the Bcl-2 pathway, but markedly inefficient in MRL-Fas(lpr) lupus mice, suggesting that defective apoptosis of isotype-switched autoreactive B cells is central to Fas ..
  26. Wueest S, Rapold R, Schoenle E, Konrad D. Fas activation in adipocytes impairs insulin-stimulated glucose uptake by reducing Akt. FEBS Lett. 2010;584:4187-92 pubmed publisher
    Fas (CD95) belongs to the superfamily of the tumor necrosis factor (TNF) receptors. Besides its key role in apoptosis, Fas contributes to non-apoptotic pathways such as cell proliferation and inflammation...
  27. Weant A, Michalek R, Khan I, Holbrook B, Willingham M, Grayson J. Apoptosis regulators Bim and Fas function concurrently to control autoimmunity and CD8+ T cell contraction. Immunity. 2008;28:218-30 pubmed publisher
    ..Mutation of Bim, a proapoptotic protein in the intrinsic death pathway, or Fas, a tumor necrosis factor receptor (TNFR) superfamily member of the extrinsic pathway, results in late-onset ..
  28. Kinjyo I, Gordon S, Intlekofer A, Dowdell K, Mooney E, Caricchio R, et al. Cutting edge: Lymphoproliferation caused by Fas deficiency is dependent on the transcription factor eomesodermin. J Immunol. 2010;185:7151-5 pubmed publisher
    A hallmark of autoimmune lymphoproliferative syndrome (ALPS), caused by mutation of the Fas death receptor, is massive lymphadenopathy from aberrant expansion of CD4(-)CD8(-) (double-negative [DN]) T cells...
  29. Rathmell J, Goodnow C. Effects of the lpr mutation on elimination and inactivation of self-reactive B cells. J Immunol. 1994;153:2831-42 pubmed
    Mice homozygous for the lymphoproliferation (lpr) mutation, which disrupts expression of the Fas cell surface molecule, develop an autoimmune syndrome with a spectrum of autoantibodies resembling human SLE...
  30. Christensen S, Shupe J, Nickerson K, Kashgarian M, Flavell R, Shlomchik M. Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus. Immunity. 2006;25:417-28 pubmed
    ..These findings reveal opposing inflammatory and regulatory roles for TLR7 and TLR9, despite similar tissue expression and signaling pathways. These results have important implications for TLR-directed therapy of autoimmune disease...
  31. Brard F, Shannon M, Prak E, Litwin S, Weigert M. Somatic mutation and light chain rearrangement generate autoimmunity in anti-single-stranded DNA transgenic MRL/lpr mice. J Exp Med. 1999;190:691-704 pubmed
    ..are expressed in patients with systemic lupus erythematosus and in lupus-prone mouse models such as the MRL/Mp-lpr/lpr (MRL/lpr) strain...
  32. Santulli Marotto S, Qian Y, Ferguson S, Clarke S. Anti-Sm B cell differentiation in Ig transgenic MRL/Mp-lpr/lpr mice: altered differentiation and an accelerated response. J Immunol. 2001;166:5292-9 pubmed
    ..In this report, we compare the regulation of anti-Sm B cells in nonautoimmune and autoimmune MRL/Mp-lpr/lpr (MRL/lpr) and bcl-2-22-Tg mice...
  33. Goulet J, Griffiths R, Ruiz P, Spurney R, Pisetsky D, Koller B, et al. Deficiency of 5-lipoxygenase abolishes sex-related survival differences in MRL-lpr/lpr mice. J Immunol. 1999;163:359-66 pubmed
    ..To investigate the role of LTs in autoimmune disease, we generated an MRL-lpr/lpr mouse line with a targeted disruption of the 5lo gene...
  34. Edwards C, Zhou T, Zhang J, Baker T, De M, Long R, et al. Inhibition of superantigen-induced proinflammatory cytokine production and inflammatory arthritis in MRL-lpr/lpr mice by a transcriptional inhibitor of TNF-alpha. J Immunol. 1996;157:1758-72 pubmed
    We have used fas-defective MRL-lpr/lpr mice to study the effects of the staphylococcal enterotoxin superantigens on the development of autoimmune, inflammatory joint disease in animals that are susceptible to the development of ..
  35. Cullen C, Bonventre P, Heeg H, Bluethmann H, Mountz J, Edwards C. A fas antigen receptor mutation allows development of toxic shock syndrome toxin-1-induced lethal shock in V beta 8.2 T-cell receptor transgenic mice. Pathobiology. 1995;63:293-304 pubmed
    ..rTSST-1 was not dependent exclusively on T-cell proliferation but was augmented by the influence of a defective fas antigen receptor expressed in homozygous lpr mice...
  36. Russell J, Rush B, Weaver C, Wang R. Mature T cells of autoimmune lpr/lpr mice have a defect in antigen-stimulated suicide. Proc Natl Acad Sci U S A. 1993;90:4409-13 pubmed
    ..Mutant lpr/lpr mice exhibit an autoimmune syndrome similar to systemic lupus erythematosus...
  37. Bonardelle D, Benihoud K, Kiger N, Bobé P. B lymphocytes mediate Fas-dependent cytotoxicity in MRL/lpr mice. J Leukoc Biol. 2005;78:1052-9 pubmed
    The Fas/Fas ligand (FasL) pathway is one of the two major effector mechanisms of T cell-mediated cytotoxicity...
  38. Mixter P, Russell J, Durie F, Budd R. Decreased CD4-CD8- TCR-alpha beta + cells in lpr/lpr mice lacking beta 2-microglobulin. J Immunol. 1995;154:2063-74 pubmed
    ..C57BL/6 (B6) mice homozygous for both the lpr mutation of the fas gene and inactivation of the beta 2-m gene (beta 2-m-/- lpr/lpr) develop less alpha beta T cell lymphadenopathy ..
  39. Nagata S, Golstein P. The Fas death factor. Science. 1995;267:1449-56 pubmed
    b>Fas ligand (FasL), a cell surface molecule belonging to the tumor necrosis factor family, binds to its receptor Fas, thus inducing apoptosis of Fas-bearing cells...
  40. Christianson G, Blankenburg R, Duffy T, Panka D, Roths J, Marshak Rothstein A, et al. beta2-microglobulin dependence of the lupus-like autoimmune syndrome of MRL-lpr mice. J Immunol. 1996;156:4932-9 pubmed
    MRL-lpr/lpr mice develop a distinctive immunologic disease characterized by accumulation of unusually large numbers of T cells in the peripheral lymphoid organs...
  41. Jevnikar A, Grusby M, Glimcher L. Prevention of nephritis in major histocompatibility complex class II-deficient MRL-lpr mice. J Exp Med. 1994;179:1137-43 pubmed
    MRL-lpr mice develop aggressive autoimmune kidney disease associated with increased or de novo renal expression of major histocompatibility complex (MHC) class II molecules and a massive systemic expansion of CD4-CD- double negative (DN) ..
  42. Zhou T, Edwards C, Mountz J. Prevention of age-related T cell apoptosis defect in CD2-fas-transgenic mice. J Exp Med. 1995;182:129-37 pubmed
    T cell dysfunction and thymic involution are major immunologic abnormalities associated with aging. Fas (CD95) is a bifunctional molecule that is critical for apoptosis and stimulation during T cell development, but the role of Fas during ..
  43. Kagi D, Vignaux F, Ledermann B, Burki K, Depraetere V, Nagata S, et al. Fas and perforin pathways as major mechanisms of T cell-mediated cytotoxicity. Science. 1994;265:528-30 pubmed
    Two molecular mechanisms of T cell-mediated cytotoxicity, one perforin-based, the other Fas-based, have been demonstrated...
  44. Weinberg J, Granger D, Pisetsky D, Seldin M, Misukonis M, Mason S, et al. The role of nitric oxide in the pathogenesis of spontaneous murine autoimmune disease: increased nitric oxide production and nitric oxide synthase expression in MRL-lpr/lpr mice, and reduction of spontaneous glomerulonephritis and arthritis by orally. J Exp Med. 1994;179:651-60 pubmed
    MRL-lpr/lpr mice spontaneously develop various manifestations of autoimmunity including an inflammatory arthropathy and immune complex glomerulonephritis...
  45. Laderach D, Koutouzov S, Bach J, Yamamoto A. Concomitant early appearance of anti-ribonucleoprotein and anti-nucleosome antibodies in lupus prone mice. J Autoimmun. 2003;20:161-70 pubmed
    ..anti-Ro52, anti-Ro60, anti-La antibodies) was performed in sequential sera from B/W, MRL+/+, MRL Yaa and MRL lpr/lpr mice...
  46. Yin Z, Bahtiyar G, Zhang N, Liu L, Zhu P, Robert M, et al. IL-10 regulates murine lupus. J Immunol. 2002;169:2148-55 pubmed
    MRL/MpJ-Tnfrsf6(lpr) (MRL/MpJ-Fas(lpr); MRL-Fas(lpr)) mice develop a spontaneous lupus syndrome closely resembling human systemic lupus erythematosus...
  47. Xiang Z, Cutler A, Brownlie R, Fairfax K, Lawlor K, Severinson E, et al. FcgammaRIIb controls bone marrow plasma cell persistence and apoptosis. Nat Immunol. 2007;8:419-29 pubmed
    ..Our results suggest that FcgammaRIIb controls bone marrow plasma cell persistence and that defects in it may contribute to autoantibody production. ..
  48. Einav S, Pozdnyakova O, Ma M, Carroll M. Complement C4 is protective for lupus disease independent of C3. J Immunol. 2002;168:1036-41 pubmed
    ..C3 in mediating systemic lupus erythematosus (SLE) was examined using a double-knockout C3(null)C4(null) Fas (CD95)-deficient mouse model...
  49. Akashi T, Nagafuchi S, Anzai K, Kitamura D, Wang J, Taniuchi I, et al. Proliferation of CD3+ B220- single-positive normal T cells was suppressed in B-cell-deficient lpr mice. Immunology. 1998;93:238-48 pubmed
    ..In order to clarify the role of B cells in the lymphoproliferation and autoimmunity of lpr mice, we created B-cell-deficient C57BL/6 (B6) lpr mice (B6lpr/lpr microMT/microMT) ..
  50. Zörnig M, Grzeschiczek A, Kowalski M, Hartmann K, Moroy T. Loss of Fas/Apo-1 receptor accelerates lymphomagenesis in E mu L-MYC transgenic mice but not in animals infected with MoMuLV. Oncogene. 1995;10:2397-401 pubmed
    ..Loss of Fas/Apo-1 receptor leads in (lpr,lpr) mice to a nonmalignant accumulation of abnormal T-cells very probably due to the lack of induction of ..
  51. Pang H, Miranda K, Fine A. Sp3 regulates fas expression in lung epithelial cells. Biochem J. 1998;333 ( Pt 1):209-13 pubmed
    By transducing an apoptotic signal in immune effector cells, Fas has been directly implicated in the control of immunological activity...
  52. Wu X, Ahn E, McKenna M, Yeo H, McDonald J. Fas binding to calmodulin regulates apoptosis in osteoclasts. J Biol Chem. 2005;280:29964-70 pubmed
    ..A point mutation of the Fas death domain in the Lpr(-cg) mouse renders Fas inactive...
  53. Hron J, Peng S. Type I IFN protects against murine lupus. J Immunol. 2004;173:2134-42 pubmed
    ..However, deficiency for the IFN-RI surprisingly worsened lymphoproliferation, autoantibody production, and end organ disease; animals doubly deficient for IFN-RI and IFN-RII developed ..
  54. Hao Z, Hampel B, Yagita H, Rajewsky K. T cell-specific ablation of Fas leads to Fas ligand-mediated lymphocyte depletion and inflammatory pulmonary fibrosis. J Exp Med. 2004;199:1355-65 pubmed
    To study the role of Fas-Fas ligand (FasL) interaction-mediated apoptosis in lymphocyte homeostasis, we generated a mutant fas allele allowing conditional inactivation of the fas gene through Cre-mediated recombination...
  55. Sekine H, Reilly C, Molano I, Garnier G, Circolo A, Ruiz P, et al. Complement component C3 is not required for full expression of immune complex glomerulonephritis in MRL/lpr mice. J Immunol. 2001;166:6444-51 pubmed
    ..in lupus nephritis, mice rendered C3 deficient by targeted deletion were backcrossed for eight generations to MRL/lpr mice, a mouse strain that spontaneously develops lupus-like disease...
  56. Peng S, Moslehi J, Craft J. Roles of interferon-gamma and interleukin-4 in murine lupus. J Clin Invest. 1997;99:1936-46 pubmed
    The systemic autoimmune syndrome of MRL/Mp-lpr/lpr (MRL/lpr) mice consists of severe pan-isotype hypergammaglobulinemia, autoantibody production, lymphadenopathy, and immune complex-associated end-organ disease...
  57. Nose M, Nishimura M, Ito M, Toh J, Shibata T, Sugisaki T. Arteritis in a novel congenic strain of mice derived from MRL/Lpr lupus mice: genetic dissociation from glomerulonephritis and limited autoantibody production. Am J Pathol. 1996;149:1763-9 pubmed
    An MRL/Mp strain of mice bearing the Fas deletion mutant gene, lpr (MRL/lpr), spontaneously develop systemic vasculitis and glomerulone phritis in the same individual, and both have been thought to be associated with an increase in ..
  58. Schneider E, Moreau G, Arnould A, Vasseur F, Khodabaccus N, Dy M, et al. Increased fetal and extramedullary hematopoiesis in Fas-deficient C57BL/6-lpr/lpr mice. Blood. 1999;94:2613-21 pubmed
    In this study, we examined the consequences of Fas deficiency on hematopoiesis in C57BL/6-lpr/lpr mice. We found a striking extramedullary increase in hematopoietic progenitor cells, comprising erythroid and nonerythroid lineages alike...
  59. Kimura M, Matsuzawa A. Autoimmunity in mice bearing lprcg: a novel mutant gene. Int Rev Immunol. 1994;11:193-210 pubmed
    A novel mutation at the lpr (lymphoproliferation)(Fas) locus, lprcg, that can complement gld (generalized lymphoproliferative disease) in induction of lymphadenopathy was discovered in CBA/K1Jms mice...
  60. Takahashi T, Tanaka M, Brannan C, Jenkins N, Copeland N, Suda T, et al. Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand. Cell. 1994;76:969-76 pubmed
    Mice homozygous for lpr (lymphoproliferation) or gld (generalized lymphoproliferative disease) develop lymphadenopathy and suffer from autoimmune disease...
  61. Izui S, Kelley V, Masuda K, Yoshida H, Roths J, Murphy E. Induction of various autoantibodies by mutant gene lpr in several strains of mice. J Immunol. 1984;133:227-33 pubmed
    The effect of the autosomal mutant gene lpr (lymphoproliferation) on the development of various autoantibodies and immune complex (IC) glomerulonephritis was investigated in four genetically distinct strains of mice: MRL/ MpJ , C3H/HeJ, ..
  62. Ohteki T, Iwamoto M, Izui S, MacDonald H. Reduced development of CD4-8-B220+ T cells but normal autoantibody production in lpr/lpr mice lacking major histocompatibility complex class I molecules. Eur J Immunol. 1995;25:37-41 pubmed
    The lpr gene has recently been shown to encode a functional mutation in the Fas receptor, a molecule involved in transducing apoptotic signals...
  63. Pellegrini M, Belz G, Bouillet P, Strasser A. Shutdown of an acute T cell immune response to viral infection is mediated by the proapoptotic Bcl-2 homology 3-only protein Bim. Proc Natl Acad Sci U S A. 2003;100:14175-80 pubmed
    We used mutant Fas-deficient (lpr) or Bim-deficient mice to investigate the role of the death receptor and Bcl-2-regulated apoptotic pathways in terminating a physiological T cell response to herpes simplex virus infection...
  64. Kuwano K, Hagimoto N, Kawasaki M, Yatomi T, Nakamura N, Nagata S, et al. Essential roles of the Fas-Fas ligand pathway in the development of pulmonary fibrosis. J Clin Invest. 1999;104:13-9 pubmed
    ..Here we demonstrated that the administration of a soluble form of Fas antigen or anti-Fas ligand antibody prevented the development of this model and that lpr and gld mice were resistant ..
  65. Lartigue A, Courville P, Auquit I, Francois A, Arnoult C, Tron F, et al. Role of TLR9 in anti-nucleosome and anti-DNA antibody production in lpr mutation-induced murine lupus. J Immunol. 2006;177:1349-54 pubmed
    ..To determine the role of TLR9 in SLE, C57BL/6-lpr/lpr-TLR9(-/-) and TLR9(+/+) mice were analyzed...
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