Fam20c

Summary

Gene Symbol: Fam20c
Description: family with sequence similarity 20, member C
Alias: C76981, DMP-4, DMP4, GEF-CK, mKIAA4081, extracellular serine/threonine protein kinase FAM20C, dentin matrix protein 4, golgi-enriched fraction casein kinase
Species: mouse
Products:     Fam20c

Top Publications

  1. Wang X, Hao J, Xie Y, Sun Y, Hernandez B, Yamoah A, et al. Expression of FAM20C in the osteogenesis and odontogenesis of mouse. J Histochem Cytochem. 2010;58:957-67 pubmed publisher
    Mutations in FAM20C were recently identified as the cause of lethal osteosclerotic bone dysplasia, which highlighted the important role of this molecule in biomineralization...
  2. Ishikawa H, Xu A, Ogura E, Manning G, Irvine K. The Raine syndrome protein FAM20C is a Golgi kinase that phosphorylates bio-mineralization proteins. PLoS ONE. 2012;7:e42988 pubmed publisher
    Raine syndrome is caused by mutations in FAM20C, which had been reported to encode a secreted component of bone and teeth...
  3. Wang X, Wang S, Lu Y, Gibson M, Liu Y, Yuan B, et al. FAM20C plays an essential role in the formation of murine teeth. J Biol Chem. 2012;287:35934-42 pubmed publisher
    b>FAM20C is highly expressed in bone and tooth...
  4. Hao J, Narayanan K, Muni T, Ramachandran A, George A. Dentin matrix protein 4, a novel secretory calcium-binding protein that modulates odontoblast differentiation. J Biol Chem. 2007;282:15357-65 pubmed
    ..Based on the nomenclature in our laboratory, this gene has been named dentin matrix protein 4 (DMP4)...
  5. Simpson M, Hsu R, Keir L, Hao J, Sivapalan G, Ernst L, et al. Mutations in FAM20C are associated with lethal osteosclerotic bone dysplasia (Raine syndrome), highlighting a crucial molecule in bone development. Am J Hum Genet. 2007;81:906-12 pubmed
    ..The region is delimited by marker D7S2563 and contains five transcriptional units. Sequence analysis of FAM20C, located within the deleted region, in six additional affected subjects revealed four homozygous mutations and two ..
  6. Wang X, Wang S, Li C, Gao T, Liu Y, Rangiani A, et al. Inactivation of a novel FGF23 regulator, FAM20C, leads to hypophosphatemic rickets in mice. PLoS Genet. 2012;8:e1002708 pubmed publisher
    Family with sequence similarity 20,-member C (FAM20C) is highly expressed in the mineralized tissues of mammals...
  7. Nalbant D, Youn H, Nalbant S, Sharma S, Cobos E, Beale E, et al. FAM20: an evolutionarily conserved family of secreted proteins expressed in hematopoietic cells. BMC Genomics. 2005;6:11 pubmed publisher
    ..proteins that has been named family with sequence similarity 20 (FAM20) with three members (FAM20A, FAM20B and FAM20C) in mammals...
  8. Liu C, Wang X, Zhang H, Xie X, Liu P, Liu Y, et al. Immortalized Mouse Floxed Fam20c Dental Papillar Mesenchymal and Osteoblast Cell Lines Retain Their Primary Characteristics. J Cell Physiol. 2015;230:2581-7 pubmed publisher
    b>Fam20c is essential for the normal mineralization of dentin and bone...
  9. Wang X, Wang J, Liu Y, Yuan B, Ruest L, Feng J, et al. The specific role of FAM20C in dentinogenesis. J Dent Res. 2015;94:330-6 pubmed publisher
    b>FAM20C is an evolutionarily reserved molecule highly expressed in mineralized tissues...

More Information

Publications18

  1. Miyagawa K, Yamazaki M, Kawai M, Nishino J, Koshimizu T, Ohata Y, et al. Dysregulated gene expression in the primary osteoblasts and osteocytes isolated from hypophosphatemic Hyp mice. PLoS ONE. 2014;9:e93840 pubmed publisher
    Osteocytes express multiple genes involved in mineral metabolism including PHEX, FGF23, DMP1 and FAM20C. In Hyp mice, a murine model for X-linked hypophosphatemia (XLH), Phex deficiency results in the overproduction of FGF23 in osteocytes,..
  2. Wang X, Jung J, Liu Y, Yuan B, Lu Y, Feng J, et al. The specific role of FAM20C in amelogenesis. J Dent Res. 2013;92:995-9 pubmed publisher
    Previously, we showed that Sox2-Cre;Fam20C(fl/fl) mice in which Fam20C was ubiquitously inactivated had severe defects in dentin, enamel, and bone, along with hypophosphatemia...
  3. Liu P, Zhang H, Liu C, Wang X, Chen L, Qin C. Inactivation of Fam20C in cells expressing type I collagen causes periodontal disease in mice. PLoS ONE. 2014;9:e114396 pubmed publisher
    b>FAM20C is a kinase that phosphorylates secretory proteins. Previous studies have shown that FAM20C plays an essential role in the formation and mineralization of bone, dentin and enamel...
  4. Wang X, Wang J, Yuan B, Lu Y, Feng J, Qin C. Overexpression of Dmp1 fails to rescue the bone and dentin defects in Fam20C knockout mice. Connect Tissue Res. 2014;55:299-303 pubmed publisher
    b>FAM20C is a kinase phosphorylating the small-integrin-binding ligand, N-linked glycoproteins (SIBLINGs), a group of extracellular matrix proteins that are essential for bone and dentin formation...
  5. Wang S, Samann A, Hu J, Simmer J. FAM20C functions intracellularly within both ameloblasts and odontoblasts in vivo. J Bone Miner Res. 2013;28:2508-11 pubmed publisher
    b>FAM20C, also known as Golgi casein kinase (G-CK), is proposed to be the archetype for a family of secreted kinases that phosphorylate target proteins in the Golgi and in extracellular matrices, but FAM20C serving an extracellular function ..
  6. Du E, Wang X, Yang W, Kaback D, Yee S, Qin C, et al. Characterization of Fam20C expression in odontogenesis and osteogenesis using transgenic mice. Int J Oral Sci. 2015;7:89-94 pubmed publisher
    Our previous studies have demonstrated that Fam20C promotes differentiation and mineralization of odontoblasts, ameloblasts, osteoblasts and osteocytes during tooth and bone development...
  7. Cui J, Xiao J, Tagliabracci V, Wen J, Rahdar M, Dixon J. A secretory kinase complex regulates extracellular protein phosphorylation. elife. 2015;4:e06120 pubmed publisher
    ..b>Fam20C is the physiological Golgi casein kinase, which phosphorylates many secreted proteins and is critical for proper ..
  8. Vogel P, Hansen G, Read R, Vance R, Thiel M, Liu J, et al. Amelogenesis imperfecta and other biomineralization defects in Fam20a and Fam20c null mice. Vet Pathol. 2012;49:998-1017 pubmed publisher
    The FAM20 family of secreted proteins consists of three members (FAM20A, FAM20B, and FAM20C) recently linked to developmental disorders suggesting roles for FAM20 proteins in modulating biomineralization processes...
  9. Yang X, Yan W, Tian Y, Ma P, Opperman L, Wang X. Family with sequence similarity member 20C is the primary but not the only kinase for the small-integrin-binding ligand N-linked glycoproteins in bone. FASEB J. 2016;30:121-8 pubmed publisher
    Recent studies have identified family with sequence similarity member 20C (FAM20C) as a kinase that phosphorylates the Ser in Ser-X-Glu/phospho-Ser (pSer) motifs in the small-integrin-binding ligand N-linked glycoproteins (SIBLINGs)...