Genomes and Genes
Gene Symbol: Fabp7
Description: fatty acid binding protein 7, brain
Alias: B-FABP, BFABP, Blbp, MRG, fatty acid-binding protein, brain, brain lipid-binding protein, brain-type fatty acid-binding protein, fatty acid-binding protein 7, mammary-derived growth inhibitor-related
- Arai Y, Funatsu N, Numayama Tsuruta K, Nomura T, Nakamura S, Osumi N. Role of Fabp7, a downstream gene of Pax6, in the maintenance of neuroepithelial cells during early embryonic development of the rat cortex. J Neurosci. 2005;25:9752-61 pubmed..Here, we identified Fabp7 (BLBP/B-FABP), a member of the fatty acid-binding protein (FABP) family, as a downregulated gene in the embryonic ..
- SMITH K, Ohkubo Y, Maragnoli M, Rasin M, Schwartz M, Sestan N, et al. Midline radial glia translocation and corpus callosum formation require FGF signaling. Nat Neurosci. 2006;9:787-97 pubmed..Hence, FGFs have an important role in the transition from radial glia to astrocytes by stimulating somal translocation of radial glial cells. ..
- Gerstner J, Bremer Q, Vander Heyden W, LaVaute T, Yin J, Landry C. Brain fatty acid binding protein (Fabp7) is diurnally regulated in astrocytes and hippocampal granule cell precursors in adult rodent brain. PLoS ONE. 2008;3:e1631 pubmed publisherBrain fatty acid binding protein (Fabp7), which is important in early nervous system development, is expressed in astrocytes and neuronal cell precursors in mature brain...
- Gerstner J, Vanderheyden W, LaVaute T, Westmark C, Rouhana L, Pack A, et al. Time of day regulates subcellular trafficking, tripartite synaptic localization, and polyadenylation of the astrocytic Fabp7 mRNA. J Neurosci. 2012;32:1383-94 pubmed publisherThe astrocyte brain fatty acid binding protein (Fabp7) has previously been shown to have a coordinated diurnal regulation of mRNA and protein throughout mouse brain, and an age-dependent decline in protein expression within ..
- Chizhikov V, Davenport J, Zhang Q, Shih E, Cabello O, Fuchs J, et al. Cilia proteins control cerebellar morphogenesis by promoting expansion of the granule progenitor pool. J Neurosci. 2007;27:9780-9 pubmed
- Hack I, Hellwig S, Junghans D, Brunne B, Bock H, Zhao S, et al. Divergent roles of ApoER2 and Vldlr in the migration of cortical neurons. Development. 2007;134:3883-91 pubmed..We present evidence for divergent roles of the two reelin receptors Vldlr and ApoER2, with Vldlr mediating a stop signal for migrating neurons and ApoER2 being essential for the migration of late generated neocortical neurons. ..
- Schreiner S, Cossais F, Fischer K, Scholz S, Bösl M, Holtmann B, et al. Hypomorphic Sox10 alleles reveal novel protein functions and unravel developmental differences in glial lineages. Development. 2007;134:3271-81 pubmed
- Müller Smith K, Williamson T, Schwartz M, Vaccarino F. Impaired motor coordination and disrupted cerebellar architecture in Fgfr1 and Fgfr2 double knockout mice. Brain Res. 2012;1460:12-24 pubmed publisher..The disrupted cerebellar size and laminar architecture resulting from loss of FGFR signaling impair motor learning and coordination in FGFR DKO mice. ..
- Woodhoo A, Alonso M, Droggiti A, Turmaine M, D Antonio M, Parkinson D, et al. Notch controls embryonic Schwann cell differentiation, postnatal myelination and adult plasticity. Nat Neurosci. 2009;12:839-47 pubmed publisher..These findings are relevant for understanding the molecular mechanisms that control Schwann cell plasticity and underlie nerve pathology, including demyelinating neuropathies and tumorigenesis. ..
- Yun S, Leong C, Zhai D, Tan Y, Lim L, Bi X, et al. Neural stem cell specific fluorescent chemical probe binding to FABP7. Proc Natl Acad Sci U S A. 2012;109:10214-7 pubmed publisher..Furthermore, we identified its binding target by proteomic analysis as fatty acid binding protein 7 (FABP7), also known as brain lipid binding protein) which is highly expressed in neural stem cells and ..
- Sharifi K, Morihiro Y, Maekawa M, Yasumoto Y, Hoshi H, Adachi Y, et al. FABP7 expression in normal and stab-injured brain cortex and its role in astrocyte proliferation. Histochem Cell Biol. 2011;136:501-13 pubmed publisher..Brain-type fatty acid-binding protein (FABP7) is abundantly expressed in neural stem cells and astrocytes of developing brain, suggesting its role in ..
- Pei Y, Brun S, Markant S, Lento W, Gibson P, Taketo M, et al. WNT signaling increases proliferation and impairs differentiation of stem cells in the developing cerebellum. Development. 2012;139:1724-33 pubmed publisher..These studies suggest that the WNT pathway is a potent regulator of cerebellar stem cell growth and differentiation. ..
- Hartfuss E, Galli R, Heins N, Gotz M. Characterization of CNS precursor subtypes and radial glia. Dev Biol. 2001;229:15-30 pubmed..for the antigens RC2, the astrocyte-specific glutamate transporter (GLAST), and the brain-lipid-binding protein (BLBP)...
- Anthony T, Klein C, Fishell G, Heintz N. Radial glia serve as neuronal progenitors in all regions of the central nervous system. Neuron. 2004;41:881-90 pubmed..Thus, radial glial populations within different CNS regions are not heterogeneous with regard to their potential to generate neurons versus glia. ..
- Britsch S, Goerich D, Riethmacher D, Peirano R, Rossner M, Nave K, et al. The transcription factor Sox10 is a key regulator of peripheral glial development. Genes Dev. 2001;15:66-78 pubmed..Haploinsufficiency of Sox10 can thus cause pigmentation and megacolon defects, which are also observed in Sox10(Dom)/+ mice and in patients with Waardenburg-Hirschsprung disease caused by heterozygous SOX10 mutations. ..
- Yu T, Yaguchi Y, Echevarria D, Martinez S, Basson M. Sprouty genes prevent excessive FGF signalling in multiple cell types throughout development of the cerebellum. Development. 2011;138:2957-68 pubmed publisher..Taken together, our data demonstrate that FGF signalling levels have to be tightly controlled throughout cerebellar development in order to maintain the normal development of multiple cell types. ..
- Feng L, Hatten M, Heintz N. Brain lipid-binding protein (BLBP): a novel signaling system in the developing mammalian CNS. Neuron. 1994;12:895-908 pubmed..postnatal cerebellar cells, we have isolated a new, brain-specific member of the lipid-binding protein family (BLBP)...
- Chou S, Perez Garcia C, Kroll T, O Leary D. Lhx2 specifies regional fate in Emx1 lineage of telencephalic progenitors generating cerebral cortex. Nat Neurosci. 2009;12:1381-9 pubmed publisher..These findings establish a genetic mechanism for determining regional-fate in the Emx1 lineage of telencephalic progenitors that generate cerebral cortex. ..
- Sonnenberg Riethmacher E, Miehe M, Stolt C, Goerich D, Wegner M, Riethmacher D. Development and degeneration of dorsal root ganglia in the absence of the HMG-domain transcription factor Sox10. Mech Dev. 2001;109:253-65 pubmed..5 and E 11.5). We show that both increased apoptosis as well as decreased proliferation of neural crest cells contribute to the observed hypomorphism. ..
- Taylor M, Yeager K, Morrison S. Physiological Notch signaling promotes gliogenesis in the developing peripheral and central nervous systems. Development. 2007;134:2435-47 pubmed..These results demonstrate that physiological Notch signaling is required for gliogenesis in vivo, independent of the role of Notch in the maintenance of undifferentiated neural progenitors. ..
- Hartfuss E, Forster E, Bock H, Hack M, Leprince P, Luque J, et al. Reelin signaling directly affects radial glia morphology and biochemical maturation. Development. 2003;130:4597-609 pubmed..These defects were correlated to a decrease in the content of brain lipid-binding protein (Blbp) and were detected exclusively in the cerebral cortex, but not in the basal ganglia of reeler mice...
- Corrales J, Rocco G, Blaess S, Guo Q, Joyner A. Spatial pattern of sonic hedgehog signaling through Gli genes during cerebellum development. Development. 2004;131:5581-90 pubmed..Taken together, these studies demonstrate that positive Shh signaling through Gli2 is required to generate a sufficient number of GCPs for proper lobe growth. ..
- Sudarov A, Joyner A. Cerebellum morphogenesis: the foliation pattern is orchestrated by multi-cellular anchoring centers. Neural Dev. 2007;2:26 pubmed
- Gaiano N, Nye J, Fishell G. Radial glial identity is promoted by Notch1 signaling in the murine forebrain. Neuron. 2000;26:395-404 pubmed..These results suggest that Notch1 promotes radial glial identity during embryogenesis, and that radial glia may be lineally related to stem cells in the adult nervous system. ..
- Gerstner J, Vander Heyden W, Lavaute T, Landry C. Profiles of novel diurnally regulated genes in mouse hypothalamus: expression analysis of the cysteine and histidine-rich domain-containing, zinc-binding protein 1, the fatty acid-binding protein 7 and the GTPase, ras-like family member 11b. Neuroscience. 2006;139:1435-48 pubmed..mRNA for the brain-type fatty acid binding protein 7 was found to change rhythmically in hypothalamic and extra-hypothalamic brain regions reaching peak ..
- Watanabe A, Toyota T, Owada Y, Hayashi T, Iwayama Y, Matsumata M, et al. Fabp7 maps to a quantitative trait locus for a schizophrenia endophenotype. PLoS Biol. 2007;5:e297 pubmed..A promising candidate on the Chromosome 10-QTL was Fabp7 (fatty acid binding protein 7, brain), a gene with functional links to the N-methyl-D-aspartic acid (NMDA) receptor and expression in ..
- Gotz M, Stoykova A, Gruss P. Pax6 controls radial glia differentiation in the cerebral cortex. Neuron. 1998;21:1031-44 pubmed..Our results suggest that Pax6 plays an essential role in the differentiation of cortical radial glia. Thus, despite their widespread distribution, radial glia cells are regionally specified in the developing CNS. ..
- Anthony T, Mason H, Gridley T, Fishell G, Heintz N. Brain lipid-binding protein is a direct target of Notch signaling in radial glial cells. Genes Dev. 2005;19:1028-33 pubmed..To elucidate pathways involved in these functions, we mapped in vivo the promoter for Blbp, a radial glial gene...
- Kurtz A, Zimmer A, Schnutgen F, Bruning G, Spener F, Muller T. The expression pattern of a novel gene encoding brain-fatty acid binding protein correlates with neuronal and glial cell development. Development. 1994;120:2637-49 pubmed
- Li G, Fang L, Fernandez G, Pleasure S. The ventral hippocampus is the embryonic origin for adult neural stem cells in the dentate gyrus. Neuron. 2013;78:658-72 pubmed publisher..The revelation of the complexity of both the embryonic origin of hippocampal LL-NSCs and the sources of Shh has important implications for the functions of LL-NSCs in the adult hippocampus. ..
- Bryda E, Kim H, Legare M, Frankel W, Noben Trauth K. High-resolution genetic and physical mapping of modifier-of-deafwaddler (mdfw) and Waltzer (Cdh23v). Genomics. 2001;73:338-42 pubmed..35-cM interval that is represented in an approximately 500-kb BAC contig. Our data suggest that mdfw and Cdh23v are allelic. ..
- Rogers N, Cheah P, Szarek E, Banerjee K, Schwartz J, Thomas P. Expression of the murine transcription factor SOX3 during embryonic and adult neurogenesis. Gene Expr Patterns. 2013;13:240-8 pubmed publisher..Together, these data show that Sox3 regulation is region-specific, consistent with it playing distinct biological roles in the dorsal telencephalon and hypothalamus. ..
- Brunne B, Zhao S, Derouiche A, Herz J, May P, Frotscher M, et al. Origin, maturation, and astroglial transformation of secondary radial glial cells in the developing dentate gyrus. Glia. 2010;58:1553-69 pubmed publisher..Time-lapse imaging of acute hippocampal slices from hGFAP-eGFP transgenic mice provides direct evidence for such a migration mode of differentiating astroglial cells in the developing dentate gyrus. ..
- Kuhar S, Feng L, Vidan S, Ross M, Hatten M, Heintz N. Changing patterns of gene expression define four stages of cerebellar granule neuron differentiation. Development. 1993;117:97-104 pubmed..The developmentally transient and spatially restricted expression of clones GC9 and GC44 identify a previously unrecognized step in cerebellar histogenesis. ..
- Grossmann K, Wende H, Paul F, Cheret C, Garratt A, Zurborg S, et al. The tyrosine phosphatase Shp2 (PTPN11) directs Neuregulin-1/ErbB signaling throughout Schwann cell development. Proc Natl Acad Sci U S A. 2009;106:16704-9 pubmed publisher..Together, our genetic and biochemical analyses demonstrate that Shp2 is an essential component in the transduction of Nrg1/ErbB signals. ..
- He S, Iwashita T, Buchstaller J, Molofsky A, Thomas D, Morrison S. Bmi-1 over-expression in neural stem/progenitor cells increases proliferation and neurogenesis in culture but has little effect on these functions in vivo. Dev Biol. 2009;328:257-72 pubmed publisher..Bmi-1 over-expression therefore has more pronounced effects in culture and does not appear to be sufficient to induce tumorigenesis in vivo. ..
- Kellerer S, Schreiner S, Stolt C, Scholz S, Bösl M, Wegner M. Replacement of the Sox10 transcription factor by Sox8 reveals incomplete functional equivalence. Development. 2006;133:2875-86 pubmed..We conclude that the extent of functional equivalence depends on the tissue and that, despite their relatedness, Sox8 and Sox10 have more unique functions than previously appreciated. ..
- Stolt C, Schlierf A, Lommes P, Hillgärtner S, Werner T, Kosian T, et al. SoxD proteins influence multiple stages of oligodendrocyte development and modulate SoxE protein function. Dev Cell. 2006;11:697-709 pubmed..Our studies reveal a complex regulatory network between different groups of Sox proteins that is essential for proper progression of oligodendrocyte development. ..
- Turner K, Schachner M, Anderson R. Cell adhesion molecule L1 affects the rate of differentiation of enteric neurons in the developing gut. Dev Dyn. 2009;238:708-15 pubmed publisher..Together, these results suggest a role for the cell adhesion molecule, L1, in the differentiation of neural crest-derived cells into enteric neurons within the developing enteric nervous system. ..
- Qiu Z, Cang Y, Goff S. Abl family tyrosine kinases are essential for basement membrane integrity and cortical lamination in the cerebellum. J Neurosci. 2010;30:14430-9 pubmed publisher..Together, these results provide compelling evidence that Abl and Arg play key redundant roles in BM maintenance and cortical lamination in the cerebellum. ..
- Béchade C, Pascual O, Triller A, Bessis A. Nitric oxide regulates astrocyte maturation in the hippocampus: involvement of NOS2. Mol Cell Neurosci. 2011;46:762-9 pubmed publisher..Our results highlight a novel developmental role of NO and NOS2 in the differentiation of radial glia and the maturation of astrocytes. ..
- Lake B, Sokol S. Strabismus regulates asymmetric cell divisions and cell fate determination in the mouse brain. J Cell Biol. 2009;185:59-66 pubmed publisher..These findings suggest that Stbm/Vangl2 functions to maintain cortical progenitors and regulates mitotic spindle orientation during asymmetric divisions in the vertebrate brain. ..
- Koo B, Yoon M, Yoon K, Im S, Kim Y, Kim C, et al. An obligatory role of mind bomb-1 in notch signaling of mammalian development. PLoS ONE. 2007;2:e1221 pubmed..Our data provide the first evidence that Mib1 is essential for Jagged as well as Deltalike ligand-mediated Notch signaling in mammalian development, while Neur1, Neur2, and Mib2 are dispensable. ..
- Kim J, Gill P, Rotin L, van Eede M, Henkelman R, Hui C, et al. Suppressor of fused controls mid-hindbrain patterning and cerebellar morphogenesis via GLI3 repressor. J Neurosci. 2011;31:1825-36 pubmed publisher..Together, our data demonstrate that SuFu controls cerebellar patterning and cell differentiation in a GLI3 repressor-dependent manner. ..
- Choe Y, Kozlova A, Graf D, Pleasure S. Bone morphogenic protein signaling is a major determinant of dentate development. J Neurosci. 2013;33:6766-75 pubmed publisher..These results suggest that Acvr1-mediated meningeal Bmp signaling regulates Lef1 expression in the dentate, regulating embryonic DG neurogenesis, DG neural stem cell niche formation, and maintenance. ..
- Parisot J, Flore G, Bertacchi M, Studer M. COUP-TFI mitotically regulates production and migration of dentate granule cells and modulates hippocampal Cxcr4 expression. Development. 2017;144:2045-2058 pubmed publisher..Together, our results indicate that COUP-TFI is required predominantly in DG progenitors for modulating expression of the Cxcr4 receptor during granule cell neurogenesis and migration. ..
- Koirala S, Jin Z, Piao X, Corfas G. GPR56-regulated granule cell adhesion is essential for rostral cerebellar development. J Neurosci. 2009;29:7439-49 pubmed publisher..These studies establish a novel role for GPR56 in the adhesion of developing neurons to basal lamina molecules and suggest that this adhesion is critical for maintenance of the pia and proper cerebellar morphogenesis. ..
- Petrone A, Battaglia F, Wang C, Dusa A, Su J, Zagzag D, et al. Receptor protein tyrosine phosphatase alpha is essential for hippocampal neuronal migration and long-term potentiation. EMBO J. 2003;22:4121-31 pubmed..Mice lacking RPTPalpha also underperform in the radial-arm water-maze test. These studies identify RPTPalpha as a key mediator of neuronal migration and synaptic plasticity. ..
- Croci L, Chung S, Masserdotti G, Gianola S, Bizzoca A, Gennarini G, et al. A key role for the HLH transcription factor EBF2COE2,O/E-3 in Purkinje neuron migration and cerebellar cortical topography. Development. 2006;133:2719-29 pubmed
- Shin D, Korada S, Raballo R, Shashikant C, Simeone A, Taylor J, et al. Loss of glutamatergic pyramidal neurons in frontal and temporal cortex resulting from attenuation of FGFR1 signaling is associated with spontaneous hyperactivity in mice. J Neurosci. 2004;24:2247-58 pubmed
- Cloëtta D, Thomanetz V, Baranek C, Lustenberger R, Lin S, Oliveri F, et al. Inactivation of mTORC1 in the developing brain causes microcephaly and affects gliogenesis. J Neurosci. 2013;33:7799-810 pubmed publisher..Together, our results show that postnatal survival, overall brain growth, and specific aspects of brain development critically depend on mTORC1 function. ..
- Li H, Radford J, Ragusa M, Shea K, McKercher S, Zaremba J, et al. Transcription factor MEF2C influences neural stem/progenitor cell differentiation and maturation in vivo. Proc Natl Acad Sci U S A. 2008;105:9397-402 pubmed publisher..Our data support a crucial role for MEF2C in programming early neuronal differentiation and proper distribution within the layers of the neocortex. ..
- Insolera R, Bazzi H, Shao W, Anderson K, Shi S. Cortical neurogenesis in the absence of centrioles. Nat Neurosci. 2014;17:1528-35 pubmed publisher..Our findings define the functions of centrioles in anchoring RGPs in the VZ and ensuring their efficient mitoses, and reveal the robust adaptability of RGPs in the developing cortex. ..
- Kipp M, Gingele S, Pott F, Clarner T, van der Valk P, Denecke B, et al. BLBP-expression in astrocytes during experimental demyelination and in human multiple sclerosis lesions. Brain Behav Immun. 2011;25:1554-68 pubmed publisher..that lesions with impaired remyelination capacity show weak expression of the radial-glia cell marker brain lipid binding protein (BLBP, also called B-FABP or FABP7)...
- Liang H, Xiao G, Yin H, Hippenmeyer S, Horowitz J, Ghashghaei H. Neural development is dependent on the function of specificity protein 2 in cell cycle progression. Development. 2013;140:552-61 pubmed publisher..Our findings implicate Sp2-dependent mechanisms as novel regulators of cell cycle progression, the absence of which disrupts neurogenesis in the embryonic and postnatal brain. ..
- Gómez López S, Wiskow O, Favaro R, Nicolis S, Price D, Pollard S, et al. Sox2 and Pax6 maintain the proliferative and developmental potential of gliogenic neural stem cells In vitro. Glia. 2011;59:1588-99 pubmed publisher..of Sox2, cells exited the cell cycle with concomitant downregulation of neural progenitor markers Nestin and Blbp. This occurred despite expression of the close relative Sox3...
- Xiang C, Baubet V, Pal S, Holderbaum L, Tatard V, Jiang P, et al. RP58/ZNF238 directly modulates proneurogenic gene levels and is required for neuronal differentiation and brain expansion. Cell Death Differ. 2012;19:692-702 pubmed publisher..Thus, RP58 may act to favor neuronal differentiation and brain growth by coherently repressing multiple proneurogenic genes in a timely manner. ..
- Haubst N, Georges Labouesse E, De Arcangelis A, Mayer U, Gotz M. Basement membrane attachment is dispensable for radial glial cell fate and for proliferation, but affects positioning of neuronal subtypes. Development. 2006;133:3245-54 pubmed..Thus, although BM attachment seems dispensable for precursor cells, an intact BM is required for adequate neuronal composition of the cerebral cortex. ..
- von Holst A, Sirko S, Faissner A. The unique 473HD-Chondroitinsulfate epitope is expressed by radial glia and involved in neural precursor cell proliferation. J Neurosci. 2006;26:4082-94 pubmed
- Knabe W, Knerlich F, Washausen S, Kietzmann T, Siren A, Brunnett G, et al. Expression patterns of erythropoietin and its receptor in the developing midbrain. Anat Embryol (Berl). 2004;207:503-12 pubmed..Whether the observed expression patterns of EPO and EPOR may reflect EPO-mediated trophic and/or antiapoptotic effects on neurons is discussed. ..
- Sugitani Y, Nakai S, Minowa O, Nishi M, Jishage K, Kawano H, et al. Brn-1 and Brn-2 share crucial roles in the production and positioning of mouse neocortical neurons. Genes Dev. 2002;16:1760-5 pubmed..These data indicate that Brn-1 and Brn-2 share roles in the production and positioning of neocortical neuron development. ..
- Li J, Habbes H, Eiberger J, Willecke K, Dermietzel R, Meier C. Analysis of connexin expression during mouse Schwann cell development identifies connexin29 as a novel marker for the transition of neural crest to precursor cells. Glia. 2007;55:93-103 pubmed..Thus, the coordinated expression of connexin proteins in cells of the embryonic and postnatal Schwann cell lineage might point to a potential role in peripheral nerve development and maturation. ..
- Lee D, Gianino S, Gutmann D. Innate neural stem cell heterogeneity determines the patterning of glioma formation in children. Cancer Cell. 2012;22:131-8 pubmed publisher..Collectively, these observations establish the importance of innate brain region NSC heterogeneity in the patterning of gliomagenesis in children and adults. ..
- Zhou C, Borello U, Rubenstein J, Pleasure S. Neuronal production and precursor proliferation defects in the neocortex of mice with loss of function in the canonical Wnt signaling pathway. Neuroscience. 2006;142:1119-31 pubmed..This analysis demonstrates that canonical Wnt signaling is required for a diverse array of developmental processes in the neocortex in addition to the previously known roles in regulating precursor proliferation and patterning. ..