Fabp5

Summary

Gene Symbol: Fabp5
Description: fatty acid binding protein 5, epidermal
Alias: E-FABP, Fabpe, Klbp, PA-FABP, mal1, fatty acid-binding protein, epidermal, uncharacterized protein LOC16592, epidermal-type fatty acid-binding protein, epithelial fatty acid-binding protein, keratinocyte lipid-binding protein, psoriasis-associated fatty acid-binding protein homolog
Species: mouse
Products:     Fabp5

Top Publications

  1. Owada Y, Abdelwahab S, Suzuki R, Iwasa H, Sakagami H, Spener F, et al. Localization of epidermal-type fatty acid binding protein in alveolar macrophages and some alveolar type II epithelial cells in mouse lung. Histochem J. 2001;33:453-7 pubmed
    ..No immunoreactive interstitial fibroblasts were encountered. Based on the present findings, possible roles of epidermal-type fatty acid binding protein in the host-defence mechanism played by alveolar macrophages are suggested. ..
  2. Puskas L, Bereczki E, Santha M, Vigh L, Csanádi G, Spener F, et al. Cholesterol and cholesterol plus DHA diet-induced gene expression and fatty acid changes in mouse eye and brain. Biochimie. 2004;86:817-24 pubmed
    ..Our results on fatty acid composition and gene expression changes may open up new alleys in understanding the complex roles of cholesterol and PUFAs in normal and pathological visual and brain function. ..
  3. Schachtrup C, Malcharek S, Haitsma J, Lachmann B, Owada Y, Binas B, et al. Activation of PPARgamma reverses a defect of surfactant synthesis in mice lacking two types of fatty acid binding protein. Biochim Biophys Acta. 2008;1781:314-20 pubmed publisher
    ..Taken together, these data suggest that PPARgamma agonists could be a tool to repair surfactant damage caused by dysfunctional alveolar lipid metabolism, and provide in vivo support for L-FABP aided signaling. ..
  4. Forootan S, Bao Z, Forootan F, Kamalian L, Zhang Y, Bee A, et al. Atelocollagen-delivered siRNA targeting the FABP5 gene as an experimental therapy for prostate cancer in mouse xenografts. Int J Oncol. 2010;36:69-76 pubmed
    The gene FABP5 encodes cutaneous fatty acid binding protein (C-FABP) that is up-regulated in prostate cancer where it acts as a putative oncogene...
  5. Matsumata M, Sakayori N, Maekawa M, Owada Y, Yoshikawa T, Osumi N. The effects of Fabp7 and Fabp5 on postnatal hippocampal neurogenesis in the mouse. Stem Cells. 2012;30:1532-43 pubmed publisher
    ..Herein, we demonstrate the effects of Fabp7, and another Fabp, Fabp5, on postnatal neurogenesis...
  6. Ogawa E, Owada Y, Ikawa S, Adachi Y, Egawa T, Nemoto K, et al. Epidermal FABP (FABP5) regulates keratinocyte differentiation by 13(S)-HODE-mediated activation of the NF-?B signaling pathway. J Invest Dermatol. 2011;131:604-12 pubmed publisher
    ..Epidermal FABP (E-FABP/FABP5) is predominantly expressed in keratinocytes and is overexpressed in the actively proliferating tissue ..
  7. Owada Y, Suzuki I, Noda T, Kondo H. Analysis on the phenotype of E-FABP-gene knockout mice. Mol Cell Biochem. 2002;239:83-6 pubmed
    ..These results demonstrate that E-FABP is responsible for the water permeability barrier of the skin, although the molecular mechanism remains to be further elucidated. ..
  8. Maeda K, Uysal K, Makowski L, Gorgun C, Atsumi G, Parker R, et al. Role of the fatty acid binding protein mal1 in obesity and insulin resistance. Diabetes. 2003;52:300-7 pubmed
    ..The fatty acid binding proteins aP2 (fatty acid binding protein [FABP]-4) and mal1 (FABP5) are closely related and both are expressed in adipocytes...
  9. Cao H, Gerhold K, Mayers J, Wiest M, Watkins S, Hotamisligil G. Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism. Cell. 2008;134:933-44 pubmed publisher
    ..Utilizing quantitative lipidomic analyses and mice deficient in adipose tissue lipid chaperones aP2 and mal1, we explored how metabolic alterations in adipose tissue are linked to whole-body metabolism through lipid signals...

More Information

Publications70

  1. Furuhashi M, Fucho R, Gorgun C, Tuncman G, Cao H, Hotamisligil G. Adipocyte/macrophage fatty acid-binding proteins contribute to metabolic deterioration through actions in both macrophages and adipocytes in mice. J Clin Invest. 2008;118:2640-50 pubmed publisher
    ..highly restricted coexpression of adipocyte/macrophage fatty acid-binding proteins (FABPs) aP2 (FABP4) and mal1 (FABP5) to examine the contribution of these lipid chaperones in macrophages and adipocytes to local and systemic ..
  2. Owada Y, Takano H, Yamanaka H, Kobayashi H, Sugitani Y, Tomioka Y, et al. Altered water barrier function in epidermal-type fatty acid binding protein-deficient mice. J Invest Dermatol. 2002;118:430-5 pubmed
    ..The molecular mechanism by which epidermal-type fatty acid binding protein contributes to the water barrier function of the skin remains to be elucidated. ..
  3. Boord J, Maeda K, Makowski L, Babaev V, Fazio S, Linton M, et al. Combined adipocyte-macrophage fatty acid-binding protein deficiency improves metabolism, atherosclerosis, and survival in apolipoprotein E-deficient mice. Circulation. 2004;110:1492-8 pubmed
    ..Insulin sensitivity is improved in obese but not in lean aP2-deficient mice. A second fatty acid-binding protein, mal1, also is expressed in adipocytes and macrophages, and mal1 deficiency produces similar effects on insulin ..
  4. Owada Y, Abdelwahab S, Kitanaka N, Sakagami H, Takano H, Sugitani Y, et al. Altered emotional behavioral responses in mice lacking brain-type fatty acid-binding protein gene. Eur J Neurosci. 2006;24:175-87 pubmed
    ..These data indicate that B-FABP is crucially involved in the fear memory and anxiety through its binding with FAs and/or its own direct effects on pertinent metabolism/signaling of FAs. ..
  5. Maeda K, Cao H, Kono K, Gorgun C, Furuhashi M, Uysal K, et al. Adipocyte/macrophage fatty acid binding proteins control integrated metabolic responses in obesity and diabetes. Cell Metab. 2005;1:107-19 pubmed
    ..Here, we developed mice with targeted mutations in two related adipocyte FABPs, aP2 and mal1, to resolve their role in systemic lipid, glucose, and energy metabolism...
  6. Bleck B, Hohoff C, Binas B, Rüstow B, Dixkens C, Hameister H, et al. Cloning and chromosomal localisation of the murine epidermal-type fatty acid binding protein gene (Fabpe). Gene. 1998;215:123-30 pubmed
    ..The 11-kb EcoRI fragment was used to localise Fabpe on chromosome 3 in the region 3A1-3 by fluorescence in-situ hybridisation.
  7. Cao H, Sekiya M, Ertunc M, Burak M, Mayers J, White A, et al. Adipocyte lipid chaperone AP2 is a secreted adipokine regulating hepatic glucose production. Cell Metab. 2013;17:768-78 pubmed publisher
    ..We conclude that aP2 is an adipokine linking adipocytes to hepatic glucose production and that neutralizing secreted aP2 may represent an effective therapeutic strategy against diabetes. ..
  8. Moore S, Holt V, Malpass L, Hines I, Wheeler M. Fatty acid-binding protein 5 limits the anti-inflammatory response in murine macrophages. Mol Immunol. 2015;67:265-75 pubmed publisher
    ..The intracellular lipid transporter, fatty acid binding protein 5 (FABP5), is highly expressed in macrophages and may play an important role in the hepatic inflammatory response after ..
  9. Hoekstra M, Stitzinger M, van Wanrooij E, Michon I, Kruijt J, Kamphorst J, et al. Microarray analysis indicates an important role for FABP5 and putative novel FABPs on a Western-type diet. J Lipid Res. 2006;47:2198-207 pubmed
    ..Time-dependent gene expression profiling identified fatty acid binding protein 5 (FABP5) and four novel FABP5-like transcripts located on chromosomes 2, 8, and 18 as important proteins in the primary ..
  10. Lan H, Cheng C, Kowalski T, Pang L, Shan L, Chuang C, et al. Small-molecule inhibitors of FABP4/5 ameliorate dyslipidemia but not insulin resistance in mice with diet-induced obesity. J Lipid Res. 2011;52:646-56 pubmed publisher
    Fatty acid binding protein-4 (FABP4) and FABP5 are two closely related FA binding proteins expressed primarily in adipose tissue and/or macrophages...
  11. Nourani M, Owada Y, Kitanaka N, Abdelwahab S, Iwasa H, Sakagami H, et al. Localization of epidermal-type fatty acid binding protein in macrophages in advanced atretic follicles of adult mice. J Mol Histol. 2005;36:391-400 pubmed
  12. Kusakari Y, Ogawa E, Owada Y, Kitanaka N, Watanabe H, Kimura M, et al. Decreased keratinocyte motility in skin wound on mice lacking the epidermal fatty acid binding protein gene. Mol Cell Biochem. 2006;284:183-8 pubmed
    ..Our analyses suggest that the E-FABP elevation may be necessary for the activation of cell motility within regenerative epidermis during wound healing. ..
  13. Pehrson J, Changolkar L, Costanzi C, Leu N. Mice without macroH2A histone variants. Mol Cell Biol. 2014;34:4523-33 pubmed publisher
    ..MacroH2A-dependent gene regulation changes substantially in postnatal development and can be strongly affected by fasting. We propose that macroH2As produce adaptive changes to gene expression, which in the liver focus on metabolism. ..
  14. Kaczocha M, Glaser S, Maher T, Clavin B, Hamilton J, O Rourke J, et al. Fatty acid binding protein deletion suppresses inflammatory pain through endocannabinoid/N-acylethanolamine-dependent mechanisms. Mol Pain. 2015;11:52 pubmed publisher
    ..Potential analgesic effects in mice lacking FABPs, however, have not been tested. Mice lacking FABP5 and FABP7, which exhibit highest affinities for endocannabinoids, possessed elevated levels of the endocannabinoid ..
  15. Suzuki R, Nourani M, Saino Saito S, Abe H, Nochi T, Kiyono H, et al. Localization of fatty acid binding protein of epidermal type common to dendritic cells and presumptive macrophages in Peyer's patches and epithelial M cells of mouse intestine. Histochem Cell Biol. 2009;132:577-84 pubmed publisher
    ..E-FABP may play some important roles in the mucosal immune reaction through Peyer's patches and associated structures. ..
  16. Zimmer J, Dyckes D, Bernlohr D, Murphy R. Fatty acid binding proteins stabilize leukotriene A4: competition with arachidonic acid but not other lipoxygenase products. J Lipid Res. 2004;45:2138-44 pubmed
    ..Previously, epithelial fatty acid binding protein (E-FABP) present in RBL-1 cells was shown to increase the half-life of LTA(4) to approximately 20 ..
  17. Jung J, Wang J, Groenendyk J, Lee D, Michalak M, Agellon L. Fatty acid binding protein (Fabp) 5 interacts with the calnexin cytoplasmic domain at the endoplasmic reticulum. Biochem Biophys Res Commun. 2017;493:202-206 pubmed publisher
    ..b>Fabp5 is a cytoplasmic protein that binds long-chain fatty acids and other lipophilic ligands...
  18. Kitanaka N, Owada Y, Okuyama R, Sakagami H, Nourani M, Aiba S, et al. Epidermal-type fatty acid binding protein as a negative regulator of IL-12 production in dendritic cells. Biochem Biophys Res Commun. 2006;345:459-66 pubmed
    ..Collectively, it is suggested that E-FABP may be a novel negative regulator of IL-12 production in DCs, and this regulation may be exerted via its involvement in the p38MAPK-mediated transcription of IL-12p35. ..
  19. Jeong Y, Hong J, Cho K, Jung H. Grape skin extract reduces adipogenesis- and lipogenesis-related gene expression in 3T3-L1 adipocytes through the peroxisome proliferator-activated receptor-? signaling pathway. Nutr Res. 2012;32:514-21 pubmed publisher
    ..Expression of the genes involved in PPAR? signaling, Adipoq, Scd1, Nr1h3, Fabp5, Scd2, and Pparg decreased with GSE treatment, whereas expression of Ppargc1a increased...
  20. Hertzel A, Smith L, Berg A, Cline G, Shulman G, Scherer P, et al. Lipid metabolism and adipokine levels in fatty acid-binding protein null and transgenic mice. Am J Physiol Endocrinol Metab. 2006;290:E814-23 pubmed
  21. Adachi Y, Hiramatsu S, Tokuda N, Sharifi K, Ebrahimi M, Islam A, et al. Fatty acid-binding protein 4 (FABP4) and FABP5 modulate cytokine production in the mouse thymic epithelial cells. Histochem Cell Biol. 2012;138:397-406 pubmed publisher
    ..chaperone, in the mouse thymus, and examined its role in the control of cytokine production in comparison with FABP5. By immunofluorescent staining, FABP4(+) cells enclosing the thymocytes were scattered throughout the thymic ..
  22. Hertzel A, Bernlohr D. Cloning and chromosomal location of the murine keratinocyte lipid-binding protein gene. Gene. 1998;221:235-43 pubmed
    The keratinocyte lipid-binding protein (KLBP) is a member of a large multigene family of intracellular fatty-acid-binding proteins...
  23. Babaev V, Runner R, Fan D, Ding L, Zhang Y, Tao H, et al. Macrophage Mal1 deficiency suppresses atherosclerosis in low-density lipoprotein receptor-null mice by activating peroxisome proliferator-activated receptor-?-regulated genes. Arterioscler Thromb Vasc Biol. 2011;31:1283-90 pubmed publisher
    The adipocyte/macrophage fatty acid-binding proteins aP2 (FABP4) and Mal1 (FABP5) are intracellular lipid chaperones that modulate systemic glucose metabolism, insulin sensitivity, and atherosclerosis...
  24. Bennaars Eiden A, Higgins L, Hertzel A, Kapphahn R, Ferrington D, Bernlohr D. Covalent modification of epithelial fatty acid-binding protein by 4-hydroxynonenal in vitro and in vivo. Evidence for a role in antioxidant biology. J Biol Chem. 2002;277:50693-702 pubmed
    ..These results indicate that E-FABP is a molecular target for 4-HNE modification and the hypothesis that E-FABP functions as an antioxidant protein by scavenging reactive lipids through covalent modification of Cys-120. ..
  25. Collins C, Watt F. Dynamic regulation of retinoic acid-binding proteins in developing, adult and neoplastic skin reveals roles for beta-catenin and Notch signalling. Dev Biol. 2008;324:55-67 pubmed publisher
    ..We show that cellular RA-binding proteins CRABP1 and CRABP2 and the fatty acid-binding protein FABP5 are dynamically expressed during skin development and in adult tissue...
  26. Jenkins Kruchten A, Bennaars Eiden A, Ross J, Shen W, Kraemer F, Bernlohr D. Fatty acid-binding protein-hormone-sensitive lipase interaction. Fatty acid dependence on binding. J Biol Chem. 2003;278:47636-43 pubmed
    ..These results suggest that binding and activation of HSL by FABPs are separate and distinct functions and that HSL contains a site for fatty acid binding that allows for FABP association. ..
  27. Bando Y, Yamamoto M, Sakiyama K, Inoue K, Takizawa S, Owada Y, et al. Expression of epidermal fatty acid binding protein (E-FABP) in septoclasts in the growth plate cartilage of mice. J Mol Histol. 2014;45:507-18 pubmed publisher
  28. Sommer C, Mostoslavsky G. RNA-Seq analysis of enteroendocrine cells reveals a role for FABP5 in the control of GIP secretion. Mol Endocrinol. 2014;28:1855-65 pubmed publisher
    ..the genes differentially expressed in GIP(GFP) cells, we identified and validated fatty acid-binding protein 5 (FABP5) as a highly expressed marker of GIP-producing cells that is absent in other enteroendocrine cell types...
  29. Syamsunarno M, Iso T, Hanaoka H, Yamaguchi A, Obokata M, Koitabashi N, et al. A critical role of fatty acid binding protein 4 and 5 (FABP4/5) in the systemic response to fasting. PLoS ONE. 2013;8:e79386 pubmed publisher
    ..We recently showed that FA binding protein 4 (FABP4) and FABP5, which are abundantly expressed in adipocytes and macrophages, are prominently expressed in capillary endothelial ..
  30. Sharifi K, Ebrahimi M, Kagawa Y, Islam A, Tuerxun T, Yasumoto Y, et al. Differential expression and regulatory roles of FABP5 and FABP7 in oligodendrocyte lineage cells. Cell Tissue Res. 2013;354:683-95 pubmed publisher
    ..We evaluate the in vivo and in vitro expression of FABP5 and FABP7 in oligodendrocyte lineage cells in the cortex and corpus callosum of adult mice, mixed cortical culture ..
  31. Yanase H, Shimizu H, Kanda T, Fujii H, Iwanaga T. Cellular localization of the diazepam binding inhibitor (DBI) in the gastrointestinal tract of mice and its coexistence with the fatty acid binding protein (FABP). Arch Histol Cytol. 2001;64:449-60 pubmed
  32. Krieg P, Feil S, Furstenberger G, Bowden G. Tumor-specific overexpression of a novel keratinocyte lipid-binding protein. Identification and characterization of a cloned sequence activated during multistage carcinogenesis in mouse skin. J Biol Chem. 1993;268:17362-9 pubmed
    ..chemically induced malignant mouse skin squamous cell carcinomas (SCCs) identified sequences, including one called mal1, that were up-regulated in their expression at both the benign papilloma and the malignant SCC stages during tumor ..
  33. DiTommaso T, Cottle D, Pearson H, Schlüter H, Kaur P, Humbert P, et al. Keratin 76 is required for tight junction function and maintenance of the skin barrier. PLoS Genet. 2014;10:e1004706 pubmed publisher
  34. Peng Y, Rideout D, Rakita S, Lee J, Murr M. Diet-induced obesity associated with steatosis, oxidative stress, and inflammation in liver. Surg Obes Relat Dis. 2012;8:73-81 pubmed publisher
    ..Understanding the complex cellular signals triggered by obesity might have profound clinical implications. ..
  35. Witting S, Brown M, Saxena R, Nabinger S, Morral N. Helper-dependent adenovirus-mediated short hairpin RNA expression in the liver activates the interferon response. J Biol Chem. 2008;283:2120-8 pubmed
    ..helper-dependent adenoviral vectors for expression of shRNA in liver, we have designed an shRNA construct to mouse fabp5 (fatty acid-binding protein 5)...
  36. Cui X, Li X, Shen X, Bae Y, Kang J, Kim N. Transcription profile in mouse four-cell, morula, and blastocyst: Genes implicated in compaction and blastocoel formation. Mol Reprod Dev. 2007;74:133-43 pubmed
    ..The identification of the genes being expressed in here will provide insight into the complex gene regulatory networks effecting compaction and blastocoel formation...
  37. Yu C, Liang X, Lipsky S, Karaaslan C, Kozakewich H, Hotamisligil G, et al. Dual role of fatty acid-binding protein 5 on endothelial cell fate: a potential link between lipid metabolism and angiogenic responses. Angiogenesis. 2016;19:95-106 pubmed publisher
    ..FABP4 and FABP5 share ~55 % amino acid sequence homology and demonstrate synergistic effects in regulation of metabolic and ..
  38. Xu Y, Wang Y, Besnard V, Ikegami M, Wert S, Heffner C, et al. Transcriptional programs controlling perinatal lung maturation. PLoS ONE. 2012;7:e37046 pubmed publisher
    ..The present study systemically mapped key regulators, bioprocesses, and transcriptional networks controlling lung maturation, providing the basis for new therapeutic strategies to enhance lung function in preterm infants. ..
  39. Gally F, Kosmider B, Weaver M, Pate K, Hartshorn K, Oberley Deegan R. FABP5 deficiency enhances susceptibility to H1N1 influenza A virus-induced lung inflammation. Am J Physiol Lung Cell Mol Physiol. 2013;305:L64-72 pubmed publisher
    ..We have previously shown that the fatty acid binding protein 5 (FABP5) has anti-inflammatory properties...
  40. Ma X, Ren X, Han P, Hu S, Wang J, Yin J. SiRNA against Fabp5 induces 3T3-L1 cells apoptosis during adipocytic induction. Mol Biol Rep. 2010;37:4003-11 pubmed publisher
    Fatty acid-binding protein 5 (Fabp5), exhibits an important role in binding free fatty acids, as well as regulating lipid metabolism and transport. The purpose of this study was to evaluate the role of Fabp5 during adipogenesis...
  41. Cao H, Maeda K, Gorgun C, Kim H, Park S, Shulman G, et al. Regulation of metabolic responses by adipocyte/macrophage Fatty Acid-binding proteins in leptin-deficient mice. Diabetes. 2006;55:1915-22 pubmed
    ..In animals lacking the adipocyte/macrophage FABP isoforms aP2 and mal1, there is strong protection against diet-induced obesity, insulin resistance, type 2 diabetes, fatty liver disease, ..
  42. Yun X, Nourani M, Abdelwahab S, Kitanaka N, Owada Y, Spener F, et al. Differential localization of brain-type and epidermal-type fatty acid binding proteins in the adrenal gland of mice. Tohoku J Exp Med. 2004;203:77-86 pubmed
    ..The possible natures of these cells immunoreactive for E-FABP are discussed in view of a subpopulation of endothelial cells or the dendritic cells of antigen-presenting property. ..
  43. Yu S, Levi L, Casadesus G, Kunos G, Noy N. Fatty acid-binding protein 5 (FABP5) regulates cognitive function both by decreasing anandamide levels and by activating the nuclear receptor peroxisome proliferator-activated receptor ?/? (PPAR?/?) in the brain. J Biol Chem. 2014;289:12748-58 pubmed publisher
    ..We show further that the fatty acid-binding protein FABP5 controls both of these functions in vivo...
  44. Zhang Y, Sun Y, Rao E, Yan F, Li Q, Zhang Y, et al. Fatty acid-binding protein E-FABP restricts tumor growth by promoting IFN-? responses in tumor-associated macrophages. Cancer Res. 2014;74:2986-98 pubmed publisher
    ..These findings identify E-FABP as a new protective factor to strengthen IFN-? responses against tumor growth. ..
  45. Pan Y, Short J, Choy K, Zeng A, Marriott P, Owada Y, et al. Fatty Acid-Binding Protein 5 at the Blood-Brain Barrier Regulates Endogenous Brain Docosahexaenoic Acid Levels and Cognitive Function. J Neurosci. 2016;36:11755-11767 pubmed
    Fatty acid-binding protein 5 (FABP5) at the blood-brain barrier contributes to the brain uptake of docosahexaenoic acid (DHA), a blood-derived polyunsaturated fatty acid essential for maintenance of cognitive function...
  46. Shimamoto C, Ohnishi T, Maekawa M, Watanabe A, Ohba H, Arai R, et al. Functional characterization of FABP3, 5 and 7 gene variants identified in schizophrenia and autism spectrum disorder and mouse behavioral studies. Hum Mol Genet. 2014;23:6495-511 pubmed publisher
    ..we identified and reported several rare non-synonymous polymorphisms of the brain-expressed genes FABP3, FABP5 and FABP7 from schizophrenia and autism spectrum disorder (ASD), diseases known to part share genetic architecture...
  47. Bando Y, Yamamoto M, Sakiyama K, Sakashita H, Taira F, Miyake G, et al. Retinoic acid regulates cell-shape and -death of E-FABP (FABP5)-immunoreactive septoclasts in the growth plate cartilage of mice. Histochem Cell Biol. 2017;148:229-238 pubmed publisher
    ..We previously reported the expression of epidermal-type fatty acid-binding protein (E-FABP, FABP5) and localization of peroxisome proliferator-activated receptor (PPAR)?/?, which mediates the cell survival or ..
  48. Zhang Y, Li Q, Rao E, Sun Y, Grossmann M, Morris R, et al. Epidermal Fatty Acid binding protein promotes skin inflammation induced by high-fat diet. Immunity. 2015;42:953-964 pubmed publisher
    ..Furthermore, E-FABP-deficient mice are completely resistant to HFD-induced skin lesions. Collectively, E-FABP represents a molecular sensor triggering HFD-induced skin inflammation. ..
  49. Powell C, Nasser M, Zhao H, Wochna J, Zhang X, Shapiro C, et al. Fatty acid binding protein 5 promotes metastatic potential of triple negative breast cancer cells through enhancing epidermal growth factor receptor stability. Oncotarget. 2015;6:6373-85 pubmed
    Fatty acid binding protein 5 (FABP5), an intracellular lipid binding protein, has been shown to play a role in various cancers, including breast cancer...
  50. Shibue K, Yamane S, Harada N, Hamasaki A, Suzuki K, Joo E, et al. Fatty acid-binding protein 5 regulates diet-induced obesity via GIP secretion from enteroendocrine K cells in response to fat ingestion. Am J Physiol Endocrinol Metab. 2015;308:E583-91 pubmed publisher
    ..A recent study shows that fatty acid-binding protein 5 (FABP5) is expressed in murine K cells and is involved in fat-induced GIP secretion...
  51. Yu S, Levi L, SIEGEL R, Noy N. Retinoic acid induces neurogenesis by activating both retinoic acid receptors (RARs) and peroxisome proliferator-activated receptor ?/? (PPAR?/?). J Biol Chem. 2012;287:42195-205 pubmed publisher
    ..proliferator-activated receptor (PPAR) ?/? and their respective cognate lipid-binding proteins CRABP-II and FABP5. RA induces neuronal differentiation, but the contributions of the two transcriptional pathways of the hormone to ..
  52. Iso T, Maeda K, Hanaoka H, Suga T, Goto K, Syamsunarno M, et al. Capillary endothelial fatty acid binding proteins 4 and 5 play a critical role in fatty acid uptake in heart and skeletal muscle. Arterioscler Thromb Vasc Biol. 2013;33:2549-57 pubmed publisher
    ..Here, we hypothesize that capillary endothelial fatty acid binding protein 4 (FABP4) and FABP5 play an important role in providing sufficient FAs to the myocardium...
  53. Sugawara T, Nemoto K, Adachi Y, Yamano N, Tokuda N, Muto M, et al. Reduced size of sebaceous gland and altered sebum lipid composition in mice lacking fatty acid binding protein 5 gene. Exp Dermatol. 2012;21:543-6 pubmed publisher
    ..In sebaceous glands, FABP5 is highly expressed in differentiated sebocytes; though, its function remains unclear...
  54. Owada Y, Suzuki R, Iwasa H, Spener F, Kondo H. Localization of epidermal-type fatty acid binding protein in the thymic epithelial cells of mice. Histochem Cell Biol. 2002;117:55-60 pubmed
  55. Li B, Reynolds J, Stout R, Bernlohr D, Suttles J. Regulation of Th17 differentiation by epidermal fatty acid-binding protein. J Immunol. 2009;182:7625-33 pubmed publisher
    ..Thus, taken together, our data indicate that expression of E-FABP by CD4(+) T cells contributes to the control of IL-6 stimulation of the IL-21/ROR/IL-17 pathway and to the Th17/Treg counterbalance. ..
  56. Reynolds J, Liu Q, Brittingham K, Liu Y, Gruenthal M, Gorgun C, et al. Deficiency of fatty acid-binding proteins in mice confers protection from development of experimental autoimmune encephalomyelitis. J Immunol. 2007;179:313-21 pubmed
    ..This study reveals that metabolic-inflammatory pathway cross-regulation by FABPs contributes to adaptive immune responses and subsequent autoimmune inflammation. ..
  57. Syamsunarno M, Iso T, Yamaguchi A, Hanaoka H, Putri M, Obokata M, et al. Fatty acid binding protein 4 and 5 play a crucial role in thermogenesis under the conditions of fasting and cold stress. PLoS ONE. 2014;9:e90825 pubmed publisher
    ..FA binding protein 4 (FABP4) and FABP5, which are abundantly expressed in adipose tissues and macrophages, have been identified as key molecules in the ..
  58. Levi L, Lobo G, Doud M, von Lintig J, Seachrist D, Tochtrop G, et al. Genetic ablation of the fatty acid-binding protein FABP5 suppresses HER2-induced mammary tumorigenesis. Cancer Res. 2013;73:4770-80 pubmed publisher
    The fatty acid-binding protein FABP5 shuttles ligands from the cytosol to the nuclear receptor PPAR?/? (encoded for by Ppar?), thereby enhancing the transcriptional activity of the receptor...
  59. Li B, Schmidt N. Epidermal Fatty Acid Binding Protein (E-FABP) Is Not Required for the Generation or Maintenance of Effector and Memory T Cells following Infection with Listeria monocytogenes. PLoS ONE. 2016;11:e0162427 pubmed publisher
    ..These data demonstrate that E-FABP is dispensable for antigen-specific T cell responses following a bacterial infection. ..
  60. Pan Y, Tian T, Park C, Lofftus S, Mei S, Liu X, et al. Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism. Nature. 2017;543:252-256 pubmed publisher
    ..that mediate lipid uptake and intracellular transport, including fatty-acid-binding proteins 4 and 5 (FABP4 and FABP5)...
  61. Pan Y, Choy K, Marriott P, Chai S, Scanlon M, Porter C, et al. Reduced blood-brain barrier expression of fatty acid-binding protein 5 is associated with increased vulnerability of APP/PS1 mice to cognitive deficits from low omega-3 fatty acid diets. J Neurochem. 2018;144:81-92 pubmed publisher
    ..blood-brain barrier (BBB) transport of plasma-derived DHA, a process facilitated by fatty acid-binding protein 5 (FABP5). This study reports a 42.1 ± 12...