Fabp4

Summary

Gene Symbol: Fabp4
Description: fatty acid binding protein 4, adipocyte
Alias: 422/aP2, AFABP, ALBP, ALBP/Ap2, Ap2, Lbpl, P15, fatty acid-binding protein, adipocyte, 3T3-L1 lipid-binding protein, P2 adipocyte protein, adipocyte lipid-binding protein, adipocyte protein aP2, adipocyte-type fatty acid-binding protein, fatty acid-binding protein 4, myelin P2 protein homolog, protein 422
Species: mouse
Products:     Fabp4

Top Publications

  1. Elmasri H, Karaaslan C, Teper Y, Ghelfi E, Weng M, Ince T, et al. Fatty acid binding protein 4 is a target of VEGF and a regulator of cell proliferation in endothelial cells. FASEB J. 2009;23:3865-73 pubmed publisher
    b>Fatty acid binding protein 4 (FABP4) plays an important role in maintaining glucose and lipid homeostasis...
  2. Calo E, Quintero Estades J, Danielian P, Nedelcu S, Berman S, Lees J. Rb regulates fate choice and lineage commitment in vivo. Nature. 2010;466:1110-4 pubmed publisher
    ..Here we use mouse models to address this hypothesis in mesenchymal tissue development and tumorigenesis. Our data show that Rb status plays a key role in establishing fate choice between bone and brown adipose tissue in vivo. ..
  3. Vergnes L, Chin R, Young S, Reue K. Heart-type fatty acid-binding protein is essential for efficient brown adipose tissue fatty acid oxidation and cold tolerance. J Biol Chem. 2011;286:380-90 pubmed publisher
    ..in mouse brown adipose tissue, despite the abundant expression of adipose-type fatty acid-binding protein, FABP4 (also known as aP2)...
  4. Boord J, Maeda K, Makowski L, Babaev V, Fazio S, Linton M, et al. Combined adipocyte-macrophage fatty acid-binding protein deficiency improves metabolism, atherosclerosis, and survival in apolipoprotein E-deficient mice. Circulation. 2004;110:1492-8 pubmed
    The adipocyte fatty acid-binding protein (FABP) aP2 is expressed by adipocytes and macrophages and modulates insulin resistance, glucose and lipid metabolism, and atherosclerosis...
  5. Gupta R, Arany Z, Seale P, Mepani R, Ye L, Conroe H, et al. Transcriptional control of preadipocyte determination by Zfp423. Nature. 2010;464:619-23 pubmed publisher
    ..This study identifies Zfp423 as a transcriptional regulator of preadipocyte determination. ..
  6. Furuhashi M, Fucho R, Gorgun C, Tuncman G, Cao H, Hotamisligil G. Adipocyte/macrophage fatty acid-binding proteins contribute to metabolic deterioration through actions in both macrophages and adipocytes in mice. J Clin Invest. 2008;118:2640-50 pubmed publisher
    ..advantage of the highly restricted coexpression of adipocyte/macrophage fatty acid-binding proteins (FABPs) aP2 (FABP4) and mal1 (FABP5) to examine the contribution of these lipid chaperones in macrophages and adipocytes to local and ..
  7. Ghelfi E, Yu C, Elmasri H, Terwelp M, Lee C, Bhandari V, et al. Fatty acid binding protein 4 regulates VEGF-induced airway angiogenesis and inflammation in a transgenic mouse model: implications for asthma. Am J Pathol. 2013;182:1425-33 pubmed publisher
    ..b>Fatty acid binding protein 4 (FABP4 or aP2) is an intracellular lipid chaperone that is induced by VEGF in endothelial cells...
  8. Cao H, Sekiya M, Ertunc M, Burak M, Mayers J, White A, et al. Adipocyte lipid chaperone AP2 is a secreted adipokine regulating hepatic glucose production. Cell Metab. 2013;17:768-78 pubmed publisher
    ..Here, we demonstrate that although established as an intracellular lipid chaperone, aP2 is in fact actively secreted from adipocytes to control liver glucose metabolism...
  9. Hotamisligil G, Johnson R, Distel R, Ellis R, Papaioannou V, Spiegelman B. Uncoupling of obesity from insulin resistance through a targeted mutation in aP2, the adipocyte fatty acid binding protein. Science. 1996;274:1377-9 pubmed
    ..Mice with a null mutation in aP2, the gene encoding the adipocyte FABP, were developmentally and metabolically normal...

More Information

Publications90

  1. Cao H, Gerhold K, Mayers J, Wiest M, Watkins S, Hotamisligil G. Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism. Cell. 2008;134:933-44 pubmed publisher
    ..Utilizing quantitative lipidomic analyses and mice deficient in adipose tissue lipid chaperones aP2 and mal1, we explored how metabolic alterations in adipose tissue are linked to whole-body metabolism through lipid ..
  2. Tian X, Hu T, Zhang H, He L, Huang X, Liu Q, et al. Vessel formation. De novo formation of a distinct coronary vascular population in neonatal heart. Science. 2014;345:90-4 pubmed publisher
    ..This mechanism of postnatal coronary vascular growth provides avenues for understanding and stimulating cardiovascular regeneration following injury and disease. ..
  3. Uysal K, Scheja L, Wiesbrock S, Bonner Weir S, Hotamisligil G. Improved glucose and lipid metabolism in genetically obese mice lacking aP2. Endocrinology. 2000;141:3388-96 pubmed
    Adipocyte fatty acid-binding protein, aP2, is a member of the intracellular fatty acid binding protein family. Previously, studies have shown increased insulin sensitivity in aP2-deficient mice with dietary obesity...
  4. Makowski L, Boord J, Maeda K, Babaev V, Uysal K, Morgan M, et al. Lack of macrophage fatty-acid-binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis. Nat Med. 2001;7:699-705 pubmed publisher
    The adipocyte fatty-acid-binding protein, aP2, has an important role in regulating systemic insulin resistance and lipid metabolism...
  5. Garin Shkolnik T, Rudich A, Hotamisligil G, Rubinstein M. FABP4 attenuates PPAR? and adipogenesis and is inversely correlated with PPAR? in adipose tissues. Diabetes. 2014;63:900-11 pubmed publisher
    b>Fatty acid binding protein 4 (FABP4, also known as aP2) is a cytoplasmic fatty acid chaperone expressed primarily in adipocytes and myeloid cells and implicated in the development of insulin resistance and atherosclerosis...
  6. Rolph M, Young T, Shum B, Gorgun C, Schmitz Peiffer C, Ramshaw I, et al. Regulation of dendritic cell function and T cell priming by the fatty acid-binding protein AP2. J Immunol. 2006;177:7794-801 pubmed
    ..Examination of a comprehensive leukocyte gene expression database revealed strong expression of the adipocyte FABP aP2 in human monocyte-derived dendritic cells (DCs)...
  7. Makowski L, Brittingham K, Reynolds J, Suttles J, Hotamisligil G. The fatty acid-binding protein, aP2, coordinates macrophage cholesterol trafficking and inflammatory activity. Macrophage expression of aP2 impacts peroxisome proliferator-activated receptor gamma and IkappaB kinase activities. J Biol Chem. 2005;280:12888-95 pubmed
    Fatty acid-binding proteins are cytosolic fatty acid chaperones, and the adipocyte isoform, aP2, plays an important role in obesity and glucose metabolism...
  8. Seale P, Bjork B, Yang W, Kajimura S, Chin S, Kuang S, et al. PRDM16 controls a brown fat/skeletal muscle switch. Nature. 2008;454:961-7 pubmed publisher
    ..Taken together, these data indicate that PRDM16 specifies the brown fat lineage from a progenitor that expresses myoblast markers and is not involved in white adipogenesis. ..
  9. Maeda K, Cao H, Kono K, Gorgun C, Furuhashi M, Uysal K, et al. Adipocyte/macrophage fatty acid binding proteins control integrated metabolic responses in obesity and diabetes. Cell Metab. 2005;1:107-19 pubmed
    ..Here, we developed mice with targeted mutations in two related adipocyte FABPs, aP2 and mal1, to resolve their role in systemic lipid, glucose, and energy metabolism...
  10. Kahraman S, Dirice E, De Jesus D, Hu J, Kulkarni R. Maternal insulin resistance and transient hyperglycemia impact the metabolic and endocrine phenotypes of offspring. Am J Physiol Endocrinol Metab. 2014;307:E906-18 pubmed publisher
    ..The relatively smaller β-cell mass/area and β-cell proliferation in these control offspring suggest cell-autonomous epigenetic mechanisms in the regulation of islet growth and development. ..
  11. Phillips M, Djian P, Green H. The nucleotide sequence of three genes participating in the adipose differentiation of 3T3 cells. J Biol Chem. 1986;261:10821-7 pubmed
    ..It remains to be demonstrated whether the information for common participation of the genes in the program of differentiation resides in controlling elements within the regions sequenced. ..
  12. Cook J, Lucas J, Sibley E, Bolanowski M, Christy R, Kelly T, et al. Expression of the differentiation-induced gene for fatty acid-binding protein is activated by glucocorticoid and cAMP. Proc Natl Acad Sci U S A. 1988;85:2949-53 pubmed
    ..We conclude that the first 858 base pairs of 5'-flanking sequence of the 422 gene contains elements that mediate activation by dexamethasone and cAMP. ..
  13. Owada Y, Abdelwahab S, Kitanaka N, Sakagami H, Takano H, Sugitani Y, et al. Altered emotional behavioral responses in mice lacking brain-type fatty acid-binding protein gene. Eur J Neurosci. 2006;24:175-87 pubmed
    ..These data indicate that B-FABP is crucially involved in the fear memory and anxiety through its binding with FAs and/or its own direct effects on pertinent metabolism/signaling of FAs. ..
  14. Queipo Ortuño M, Escote X, Ceperuelo Mallafré V, Garrido Sanchez L, Miranda M, Clemente Postigo M, et al. FABP4 dynamics in obesity: discrepancies in adipose tissue and liver expression regarding circulating plasma levels. PLoS ONE. 2012;7:e48605 pubmed publisher
    b>FABP4 is predominantly expressed in adipose tissue, and its circulating levels are linked with obesity and a poor atherogenic profile...
  15. Reynolds J, Liu Q, Brittingham K, Liu Y, Gruenthal M, Gorgun C, et al. Deficiency of fatty acid-binding proteins in mice confers protection from development of experimental autoimmune encephalomyelitis. J Immunol. 2007;179:313-21 pubmed
    ..This study reveals that metabolic-inflammatory pathway cross-regulation by FABPs contributes to adaptive immune responses and subsequent autoimmune inflammation. ..
  16. Shan T, Liu W, Kuang S. Fatty acid binding protein 4 expression marks a population of adipocyte progenitors in white and brown adipose tissues. FASEB J. 2013;27:277-87 pubmed publisher
    ..Various markers have been used to identify either adipocyte progenitors or mature adipocytes. The fatty acid binding protein 4 (FABP4), commonly known as adipocyte protein 2 (aP2), has been extensively used as a marker for ..
  17. Johnson R, Sheng M, Greenberg M, Kolodner R, Papaioannou V, Spiegelman B. Targeting of nonexpressed genes in embryonic stem cells via homologous recombination. Science. 1989;245:1234-6 pubmed
    ..different loci: c-fos, which is expressed at a low level in ES cells, and two genes, adipsin and adipocyte P2 (aP2), which are transcribed specifically in adipose cells and are not expressed at detectable levels in ES cells...
  18. Xu Z, Bernlohr D, Banaszak L. Crystal structure of recombinant murine adipocyte lipid-binding protein. Biochemistry. 1992;31:3484-92 pubmed
    Adipocyte lipid-binding protein (ALBP) is the adipocyte member of an intracellular hydrophobic ligand-binding protein family. ALBP is phosphorylated by the insulin receptor kinase upon insulin stimulation...
  19. Stephens J, Pekala P. Transcriptional repression of the C/EBP-alpha and GLUT4 genes in 3T3-L1 adipocytes by tumor necrosis factor-alpha. Regulations is coordinate and independent of protein synthesis. J Biol Chem. 1992;267:13580-4 pubmed
    ..assays indicate a coordinate transcriptional repression of both GLUT4 and C/EBP-alpha genes (as well as the 422/aP2 gene, the adipocyte lipid-binding protein, whose expression has also been proposed to be controlled by C/EBP-alpha)...
  20. Cao H, Maeda K, Gorgun C, Kim H, Park S, Shulman G, et al. Regulation of metabolic responses by adipocyte/macrophage Fatty Acid-binding proteins in leptin-deficient mice. Diabetes. 2006;55:1915-22 pubmed
    ..In animals lacking the adipocyte/macrophage FABP isoforms aP2 and mal1, there is strong protection against diet-induced obesity, insulin resistance, type 2 diabetes, fatty liver ..
  21. Nourani M, Owada Y, Kitanaka N, Sakagami H, Hoshi H, Iwasa H, et al. Occurrence of immunoreactivity for adipocyte-type fatty acid binding protein in degenerating granulosa cells in atretic antral follicles of mouse ovary. J Mol Histol. 2005;36:491-7 pubmed
    ..The present findings suggest that A-FABP is involved in the apoptosis of ovarian granulosa cells, probably through its interaction with peroxisome proliferator activated receptors. ..
  22. Hunt C, Ro J, Dobson D, Min H, Spiegelman B. Adipocyte P2 gene: developmental expression and homology of 5'-flanking sequences among fat cell-specific genes. Proc Natl Acad Sci U S A. 1986;83:3786-90 pubmed
    We have isolated the mouse gene encoding adipocyte P2, aP2, the differentiation-dependent adipocyte protein homologous to myelin P2...
  23. Picard F, Kurtev M, Chung N, Topark Ngarm A, Senawong T, Machado De Oliveira R, et al. Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma. Nature. 2004;429:771-6 pubmed
    ..As a reduction in fat is sufficient to extend murine lifespan, our results provide a possible molecular pathway connecting calorie restriction to life extension in mammals. ..
  24. Kang S, Akerblad P, Kiviranta R, Gupta R, Kajimura S, Griffin M, et al. Regulation of early adipose commitment by Zfp521. PLoS Biol. 2012;10:e1001433 pubmed publisher
    ..Because Zfp521 is known to promote bone development, our results suggest that it acts as a critical switch in the commitment decision between the adipogenic and osteogenic lineages. ..
  25. Van Dyck F, Scroyen I, Declercq J, Sciot R, Kahn B, Lijnen R, et al. aP2-Cre-mediated expression activation of an oncogenic PLAG1 transgene results in cavernous angiomatosis in mice. Int J Oncol. 2008;32:33-40 pubmed
    ..To further delineate the oncogenic spectrum of PLAG1 in mice, we induced aP2-Cre-mediated overexpression of PLAG1 in offspring from crossbreeding PTMS1 mice with aP2-Cre transgenic mice...
  26. Hertzel A, Xu H, Downey M, Kvalheim N, Bernlohr D. Fatty acid binding protein 4/aP2-dependent BLT1R expression and signaling. J Lipid Res. 2017;58:1354-1361 pubmed publisher
    Previous studies have shown that reduced levels of the adipocyte fatty acid binding protein (FABP)4 (AFABP/aP2), result in metabolic improvement including potentiated insulin sensitivity and attenuated atherosclerosis...
  27. Iso T, Maeda K, Hanaoka H, Suga T, Goto K, Syamsunarno M, et al. Capillary endothelial fatty acid binding proteins 4 and 5 play a critical role in fatty acid uptake in heart and skeletal muscle. Arterioscler Thromb Vasc Biol. 2013;33:2549-57 pubmed publisher
    ..Here, we hypothesize that capillary endothelial fatty acid binding protein 4 (FABP4) and FABP5 play an important role in providing sufficient FAs to the myocardium...
  28. Atkins G, Wang Y, Mahabeleshwar G, Shi H, Gao H, Kawanami D, et al. Hemizygous deficiency of Krüppel-like factor 2 augments experimental atherosclerosis. Circ Res. 2008;103:690-3 pubmed publisher
    ..These novel observations establish that KLF2 is an atheroprotective factor. ..
  29. He L, Tian X, Zhang H, Wythe J, Zhou B. Fabp4-CreER lineage tracing reveals two distinctive coronary vascular populations. J Cell Mol Med. 2014;18:2152-6 pubmed publisher
    ..Herein, we present new coronary vasculature lineage tracing results using a novel tool, Fabp4-CreER. Our results confirm the distinct existence of two unique CVPs...
  30. Zhang Y, Rao E, Zeng J, Hao J, Sun Y, Liu S, et al. Adipose Fatty Acid Binding Protein Promotes Saturated Fatty Acid-Induced Macrophage Cell Death through Enhancing Ceramide Production. J Immunol. 2017;198:798-807 pubmed publisher
  31. Qu B, Ma Y, Yan M, Gong K, Liang F, Deng S, et al. Sirtuin1 promotes osteogenic differentiation through downregulation of peroxisome proliferator-activated receptor ? in MC3T3-E1 cells. Biochem Biophys Res Commun. 2016;478:439-445 pubmed publisher
    ..activity and expression of adipocyte-specific genes, including acetyl-coenzyme A carboxylase (Acc) and fatty acid binding protein 4 (Fabp4)...
  32. Walenna N, Kurihara Y, Chou B, Ishii K, Soejima T, Itoh R, et al. Chlamydia pneumoniae exploits adipocyte lipid chaperone FABP4 to facilitate fat mobilization and intracellular growth in murine adipocytes. Biochem Biophys Res Commun. 2018;495:353-359 pubmed publisher
    Fatty acid-binding protein 4 (FABP4), a cytosolic lipid chaperone predominantly expressed in adipocytes and macrophages, modulates lipid fluxes, trafficking, signaling, and metabolism...
  33. Saint Geniez M, Ghelfi E, Liang X, Yu C, Spencer C, Abend S, et al. Fatty acid binding protein 4 deficiency protects against oxygen-induced retinopathy in mice. PLoS ONE. 2014;9:e96253 pubmed publisher
    ..b>Fatty acid binding protein 4 (FABP4) is an intracellular lipid chaperone that is induced by VEGF in a subset of endothelial cells...
  34. Ge K, Cho Y, Guo H, Hong T, Guermah M, Ito M, et al. Alternative mechanisms by which mediator subunit MED1/TRAP220 regulates peroxisome proliferator-activated receptor gamma-stimulated adipogenesis and target gene expression. Mol Cell Biol. 2008;28:1081-91 pubmed
    ..for PPARgamma-mediated target gene activation and for recruitment of Mediator to a PPAR response element on the aP2 target gene promoter...
  35. Lee K, Villena J, Moon Y, Kim K, Lee S, Kang C, et al. Inhibition of adipogenesis and development of glucose intolerance by soluble preadipocyte factor-1 (Pref-1). J Clin Invest. 2003;111:453-61 pubmed
    ..the Pref-1/hFc transgene in adipose tissue, driven by the adipocyte fatty acid-binding protein (aP2, also known as aFABP) promoter, showed a substantial decrease in total fat pad weight...
  36. Santos J, Cole Y, Pellicer A. Phylogenetic relationships among laboratory and wild-origin Mus musculus strains on the basis of genomic DNA RFLPs. Mamm Genome. 1993;4:485-92 pubmed
    ..Natural. 106,283, 1972) and unbiased minimum (Genetics 89,583, 1978), Edwards (Biometrics 27,873, 1971; Genetic Distance, p. 41, 1974) and Rogers modified (1986). ..
  37. Hertzel A, Bennaars Eiden A, Bernlohr D. Increased lipolysis in transgenic animals overexpressing the epithelial fatty acid binding protein in adipose cells. J Lipid Res. 2002;43:2105-11 pubmed
    ..These results demonstrate that there is a positive relationship between lipolysis and the total level of FABP but not between lipolysis and a specific FABP type. ..
  38. Koeck T, Willard B, Crabb J, Kinter M, Stuehr D, Aulak K. Glucose-mediated tyrosine nitration in adipocytes: targets and consequences. Free Radic Biol Med. 2009;46:884-92 pubmed publisher
    ..The nitration of adipocyte fatty acid binding protein (FABP4) at Tyr19 decreases, similar to phosphorylation, the binding of palmitic acid to the fatty acid-free protein...
  39. Furuhashi M, Fuseya T, Murata M, Hoshina K, Ishimura S, Mita T, et al. Local Production of Fatty Acid-Binding Protein 4 in Epicardial/Perivascular Fat and Macrophages Is Linked to Coronary Atherosclerosis. Arterioscler Thromb Vasc Biol. 2016;36:825-34 pubmed publisher
    Fatty acid-binding protein 4 (FABP4) is expressed in adipocytes and macrophages, and elevated circulating FABP4 level is associated with obesity-mediated metabolic phenotype...
  40. Ertunc M, Sikkeland J, Fenaroli F, Griffiths G, Daniels M, Cao H, et al. Secretion of fatty acid binding protein aP2 from adipocytes through a nonclassical pathway in response to adipocyte lipase activity. J Lipid Res. 2015;56:423-34 pubmed publisher
    Adipocyte fatty acid binding protein 4, aP2, contributes to the pathogenesis of several common diseases including type 2 diabetes, atherosclerosis, fatty liver disease, asthma, and cancer...
  41. Gillilan R, Ayers S, Noy N. Structural basis for activation of fatty acid-binding protein 4. J Mol Biol. 2007;372:1246-60 pubmed
    Fatty acid-binding protein 4 (FABP4) delivers ligands from the cytosol to the nuclear receptor PPARgamma in the nucleus, thereby enhancing the transcriptional activity of the receptor...
  42. Zhang W, Chai B, Li J, Wang H, Mulholland M. Effect of des-acyl ghrelin on adiposity and glucose metabolism. Endocrinology. 2008;149:4710-6 pubmed publisher
    ..Here, we examined the effect of des-acyl ghrelin driven from the fatty acid-binding protein-4 (FABP4) promoter on adiposity and glucose metabolism...
  43. Xu Y, Wang Y, Besnard V, Ikegami M, Wert S, Heffner C, et al. Transcriptional programs controlling perinatal lung maturation. PLoS ONE. 2012;7:e37046 pubmed publisher
    ..The present study systemically mapped key regulators, bioprocesses, and transcriptional networks controlling lung maturation, providing the basis for new therapeutic strategies to enhance lung function in preterm infants. ..
  44. Xu H, Hertzel A, Steen K, Bernlohr D. Loss of Fatty Acid Binding Protein 4/aP2 Reduces Macrophage Inflammation Through Activation of SIRT3. Mol Endocrinol. 2016;30:325-34 pubmed publisher
    ..Previous work using high fat-fed mice has shown that ablation of the adipocyte fatty acid binding protein (FABP4/aP2) in macrophages leads to an antiinflammatory state both in situ and in vivo, and the mechanism is linked, in ..
  45. Coleman S, Park Y, Lee J. Unsaturated fatty acids repress the expression of adipocyte fatty acid binding protein via the modulation of histone deacetylation in RAW 264.7 macrophages. Eur J Nutr. 2011;50:323-30 pubmed publisher
    ..The mechanism may involve histone deacetylation and anti-inflammatory effect of unsaturated fatty acids may be at least in part attributed to their repression of A-FABP expression in RAW 264.7 macrophages. ..
  46. Liu Z, Fan H, Liu X, Ding X, Wang T, Sui G, et al. Overexpression of the A-FABP gene facilitates intermuscular fat deposition in transgenic mice. Genet Mol Res. 2015;14:2742-9 pubmed publisher
    ..In addition, triglycerides were remarkably higher in the skeletal muscle but lower in the myocardium of transgenic mice. Thus, overexpression of cattle A-FABP gene promoted fat deposition in the skeletal muscle of transgenic mice. ..
  47. Donati G, Proserpio V, Lichtenberger B, Natsuga K, Sinclair R, Fujiwara H, et al. Epidermal Wnt/β-catenin signaling regulates adipocyte differentiation via secretion of adipogenic factors. Proc Natl Acad Sci U S A. 2014;111:E1501-9 pubmed publisher
  48. Cook K, Hunt C, Spiegelman B. Developmentally regulated mRNAs in 3T3-adipocytes: analysis of transcriptional control. J Cell Biol. 1985;100:514-20 pubmed
  49. Nikolopoulou E, Papacleovoulou G, Jean Alphonse F, Grimaldi G, Parker M, Hanyaloglu A, et al. Arachidonic acid-dependent gene regulation during preadipocyte differentiation controls adipocyte potential. J Lipid Res. 2014;55:2479-90 pubmed publisher
    ..AA caused the upregulation of fatty acid binding protein 4 (FABP4/aP2) following 24 h of differentiation...
  50. Pan Y, Tian T, Park C, Lofftus S, Mei S, Liu X, et al. Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism. Nature. 2017;543:252-256 pubmed publisher
    ..molecules that mediate lipid uptake and intracellular transport, including fatty-acid-binding proteins 4 and 5 (FABP4 and FABP5)...
  51. Scheja L, Makowski L, Uysal K, Wiesbrock S, Shimshek D, Meyers D, et al. Altered insulin secretion associated with reduced lipolytic efficiency in aP2-/- mice. Diabetes. 1999;48:1987-94 pubmed
    Recent studies have shown that genetic deficiency of the adipocyte fatty acid-binding protein (aP2) results in minor alterations of plasma lipids and adipocyte development but provides significant protection from dietary obesity-induced ..
  52. Yang A, Zhang H, Sun Y, Yang X, Wang N, Zhu G, et al. High-methionine diets accelerate atherosclerosis by HHcy-mediated FABP4 gene demethylation pathway via DNMT1 in ApoE(-/-) mice. FEBS Lett. 2015;589:3998-4009 pubmed publisher
    ..We investigated the effects of Hcy on fatty acid-binding protein 4 (FABP4), and tested our hypothesis that Hcy-induced atherosclerosis is mediated by increased FABP4 expression and ..
  53. Nuotio Antar A, Poungvarin N, Li M, Schupp M, Mohammad M, Gerard S, et al. FABP4-Cre Mediated Expression of Constitutively Active ChREBP Protects Against Obesity, Fatty Liver, and Insulin Resistance. Endocrinology. 2015;156:4020-32 pubmed publisher
    ..a transgenic mouse that overexpresses a constitutively active ChREBP isoform under the control of the fatty acid binding protein 4-Cre-driven promoter (FaChOX)...
  54. Ross S, Hemati N, Longo K, Bennett C, Lucas P, Erickson R, et al. Inhibition of adipogenesis by Wnt signaling. Science. 2000;289:950-3 pubmed
    ..Disruption of Wnt signaling also causes transdifferentiation of myoblasts into adipocytes in vitro, highlighting the importance of this pathway not only in adipocyte differentiation but also in mesodermal cell fate determination. ..
  55. Carmona M, Iglesias R, Obregon M, Darlington G, Villarroya F, Giralt M. Mitochondrial biogenesis and thyroid status maturation in brown fat require CCAAT/enhancer-binding protein alpha. J Biol Chem. 2002;277:21489-98 pubmed
  56. Jenkins Kruchten A, Bennaars Eiden A, Ross J, Shen W, Kraemer F, Bernlohr D. Fatty acid-binding protein-hormone-sensitive lipase interaction. Fatty acid dependence on binding. J Biol Chem. 2003;278:47636-43 pubmed
    ..These results suggest that binding and activation of HSL by FABPs are separate and distinct functions and that HSL contains a site for fatty acid binding that allows for FABP association. ..
  57. Yan F, Shen N, Pang J, Zhang Y, Rao E, Bode A, et al. Fatty acid-binding protein FABP4 mechanistically links obesity with aggressive AML by enhancing aberrant DNA methylation in AML cells. Leukemia. 2017;31:1434-1442 pubmed publisher
    ..the molecular mechanisms by which obesity favors AML growth and uncovered the fatty acid-binding protein 4 (FABP4) and DNA methyltransferase 1 (DNMT1) regulatory axis that mediates aggressive AML in obesity...
  58. Shaughnessy S, Smith E, Kodukula S, Storch J, Fried S. Adipocyte metabolism in adipocyte fatty acid binding protein knockout mice (aP2-/-) after short-term high-fat feeding: functional compensation by the keratinocyte [correction of keritinocyte] fatty acid binding protein. Diabetes. 2000;49:904-11 pubmed
    Mice null for adipocyte fatty acid binding protein (AFABP) compensate by increasing expression of keratinocyte fatty acid binding protein (KFABP) (Hotamisligil et al. Science 274:1377-1379, 1996)...
  59. Zhou H, Wan B, Grubisic I, Kaplan T, Tjian R. TAF7L modulates brown adipose tissue formation. elife. 2014;3: pubmed publisher
    ..Our findings suggest that the presence of the tissue-specific TAF7L subunit in TFIID functions to promote long-range chromatin interactions during BAT lineage specification. ..
  60. Syamsunarno M, Iso T, Hanaoka H, Yamaguchi A, Obokata M, Koitabashi N, et al. A critical role of fatty acid binding protein 4 and 5 (FABP4/5) in the systemic response to fasting. PLoS ONE. 2013;8:e79386 pubmed publisher
    ..We recently showed that FA binding protein 4 (FABP4) and FABP5, which are abundantly expressed in adipocytes and macrophages, are prominently expressed in capillary ..
  61. Cho S, Yang J, Her S, Choi H, Jung J, Sun H, et al. Osteoblast-targeted overexpression of PPAR? inhibited bone mass gain in male mice and accelerated ovariectomy-induced bone loss in female mice. J Bone Miner Res. 2011;26:1939-52 pubmed publisher
    ..In conclusion, in vivo osteoblast-specific overexpression of PPAR? negatively regulates bone mass in male mice and accelerates estrogen-deficiency-related bone loss in female mice. ..
  62. Makkar A, Mishima T, Chang G, Scifres C, Sadovsky Y. Fatty acid binding protein-4 is expressed in the mouse placental labyrinth, yet is dispensable for placental triglyceride accumulation and fetal growth. Placenta. 2014;35:802-7 pubmed publisher
    Fatty Acid Binding Protein-4 (FABP4) is a member of a family of FABP proteins that regulate intracellular lipid trafficking in diverse tissues...
  63. Zhang J, Qiao C, Chang L, Guo Y, Fan Y, Villacorta L, et al. Cardiomyocyte Overexpression of FABP4 Aggravates Pressure Overload-Induced Heart Hypertrophy. PLoS ONE. 2016;11:e0157372 pubmed publisher
    b>Fatty acid binding protein 4 (FABP4) is a member of the intracellular lipid-binding protein family, responsible for the transportation of fatty acids...
  64. Shiota M, Heike T, Haruyama M, Baba S, Tsuchiya A, Fujino H, et al. Isolation and characterization of bone marrow-derived mesenchymal progenitor cells with myogenic and neuronal properties. Exp Cell Res. 2007;313:1008-23 pubmed
    ..Thus, sphere-derived cells represent a new approach to enhance the multi-differentiation potential of murine bone marrow. ..
  65. Navia B, Ferrer B, Giralt M, Comes G, Carrasco J, Molinero A, et al. Interleukin-6 deletion in mice driven by aP2-Cre-ERT2 prevents against high-fat diet-induced gain weight and adiposity in female mice. Acta Physiol (Oxf). 2014;211:585-96 pubmed publisher
    ..of this study was to analyse the effects of tissue-specific deletion of IL-6 using a fatty acid binding protein (aP2) promoter-Cre inducible system (aP2-Cre-ERT2)...
  66. Xu H, Hertzel A, Steen K, Wang Q, Suttles J, Bernlohr D. Uncoupling lipid metabolism from inflammation through fatty acid binding protein-dependent expression of UCP2. Mol Cell Biol. 2015;35:1055-65 pubmed publisher
    ..Targeted deletion of the murine fatty acid binding protein (FABP4/aP2) uncouples obesity from inflammation although the mechanism underlying this finding has remained enigmatic...
  67. Tzeng J, Byun J, Park J, Yamamoto T, Schesing K, Tian B, et al. An Ideal PPAR Response Element Bound to and Activated by PPARα. PLoS ONE. 2015;10:e0134996 pubmed publisher
    ..Taken altogether, the provided PPRE sequence definition contributes to the understanding of PPARα signaling by identifying PPARα direct target genes with functional PPARα response elements. ..
  68. Hu B, Guo Y, Garbacz W, Jiang M, Xu M, Huang H, et al. Fatty acid binding protein-4 (FABP4) is a hypoxia inducible gene that sensitizes mice to liver ischemia/reperfusion injury. J Hepatol. 2015;63:855-62 pubmed publisher
    b>Fatty acid binding protein 4 (FABP4) has been known as a mediator of inflammatory response in the macrophages and adipose tissue, but its hepatic function is poorly understood...
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    ..refractory to PPARgamma-stimulated adipogenesis and fail to express the PPARgamma-responsive adipogenic marker gene aP2. However, the specific roles for MLL3 and MLL4 in adipogenesis remain undefined...
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    Fatty acid-binding protein 4 (Fabp4) is highly expressed in the secondary decidual zone of mouse decidua and deciduoma and stromal cells under in vitro decidualization...
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    ..These results challenge the existing model on transcriptional regulation in the early phase of adipogenesis and highlight the need of studying adipogenesis in vivo. ..
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    ..Thus, A-FABP deficiency protects mice against MI/R-induced and/or diabetes-induced cardiac injury at least partially through activation of the eNOS/NO pathway and reduction in superoxide anion production. ..
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    ..reductase-deficient MSCs, diminishing binding to its downstream target fatty acid-binding protein 4 (FABP4)...
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    ..This indicates that liver GR might be more important in development of MS in dexamethasone-treated mice, whereas adipose GR plays a little role in these paradigms. ..
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    ..From these experiments we conclude that, under precisely standardized PCR conditions, the DNA molecules amplified with these arbitrarily designed primers are useful and reliable markers for genetic mapping in both mouse and rat. ..