Gene Symbol: Fa2h
Description: fatty acid 2-hydroxylase
Alias: FAAH, Faxdc1, G630055L08Rik, fatty acid 2-hydroxylase, fatty acid alpha-hydroxylase, fatty acid hydroxylase domain containing 1
Eckhardt M, Yaghootfam A, Fewou S, Zöller I, Gieselmann V. A mammalian fatty acid hydroxylase responsible for the formation of alpha-hydroxylated galactosylceramide in myelin. Biochem J. 2005;388:245-54 pubmed
..the basis of sequence similarity to a yeast C26 fatty acid hydroxylase, we have identified a murine cDNA encoding FA2H (fatty acid 2-hydroxylase)...
Alderson N, Maldonado E, Kern M, Bhat N, Hama H. FA2H-dependent fatty acid 2-hydroxylation in postnatal mouse brain. J Lipid Res. 2006;47:2772-80 pubmed
..To fill this gap, we have identified a human fatty acid 2-hydroxylase gene (FA2H) that is highly expressed in brain...
Zöller I, Meixner M, Hartmann D, Bussow H, Meyer R, Gieselmann V, et al
. Absence of 2-hydroxylated sphingolipids is compatible with normal neural development but causes late-onset axon and myelin sheath degeneration. J Neurosci. 2008;28:9741-54 pubmed publisher
..To prove this hypothesis, we generated mice lacking a functional fatty acid 2-hydroxylase (FA2H) gene. FA2H-deficient (FA2H(-/-)) mice lacked 2-hydroxylated sphingolipids in the brain and in peripheral nerves...
Charles C, Abler A, Lau L. cDNA sequence of a growth factor-inducible immediate early gene and characterization of its encoded protein. Oncogene. 1992;7:187-90 pubmed
..Using affinity-purified antibodies, we have identified the 3CH134 protein in serum-stimulated Balb/c 3T3 cells and determined that it has a short half-life. ..
Guo L, Zhou D, Pryse K, Okunade A, Su X. Fatty acid 2-hydroxylase mediates diffusional mobility of Raft-associated lipids, GLUT4 level, and lipogenesis in 3T3-L1 adipocytes. J Biol Chem. 2010;285:25438-47 pubmed publisher
..Mammalian fatty acid 2-hydroxylase (FA2H) was recently identified and suggested to catalyze the initial step of straight chain fatty acid alpha-oxidation...
Meixner M, Jungnickel J, Grothe C, Gieselmann V, Eckhardt M. Myelination in the absence of UDP-galactose:ceramide galactosyl-transferase and fatty acid 2 -hydroxylase. BMC Neurosci. 2011;12:22 pubmed publisher
..to test this hypothesis, we have generated Cgt-/- mice with an additional deletion of the fatty acid 2-hydroxylase (Fa2h) gene. Fa2h-/-/Cgt-/- double-deficient mice lack sulfatide, GalCer, and in addition HFA-GlcCer and sphingomyelin...
Potter K, Kern M, Fullbright G, Bielawski J, Scherer S, Yum S, et al
. Central nervous system dysfunction in a mouse model of FA2H deficiency. Glia. 2011;59:1009-21 pubmed publisher
Fatty acid 2-hydroxylase (FA2H) is responsible for the synthesis of myelin galactolipids containing hydroxy fatty acid (hFA) as the N-acyl chain...
Maier H, Meixner M, Hartmann D, Sandhoff R, Wang Eckhardt L, Zöller I, et al
. Normal fur development and sebum production depends on fatty acid 2-hydroxylase expression in sebaceous glands. J Biol Chem. 2011;286:25922-34 pubmed publisher
..Fatty acid 2-hydroxylase (FA2H), required for the synthesis of 2-hydroxylated sphingolipids in various organs, is highly expressed in skin, and ..
von Gerichten J, Schlosser K, Lamprecht D, Morace I, Eckhardt M, Wachten D, et al
. Diastereomer-specific quantification of bioactive hexosylceramides from bacteria and mammals. J Lipid Res. 2017;58:1247-1258 pubmed publisher
..Finally, this method is shown to separate corresponding hexosylsphingosine standards, promoting its applicability in further investigations. ..