F5

Summary

Gene Symbol: F5
Description: coagulation factor V
Alias: AI173222, Cf-5, Cf5, activated protein C cofactor
Species: mouse

Top Publications

  1. doi Hypercoagulability inhibits monocyte transendothelial migration through protease-activated receptor-1-, phospholipase-Cbeta-, phosphoinositide 3-kinase-, and nitric oxide-dependent signaling in monocytes and promotes plaque stability
    Stefanie Seehaus
    Department of Medicine I and Clinical Chemistry, University of Heidelberg, INF 410, 69120 Heidelberg, Germany
    Circulation 120:774-84. 2009
  2. ncbi Spontaneous thrombosis in mice carrying the factor V Leiden mutation
    J Cui
    Division of Medical Genetics, Department of Human Genetics, University of Michigan Medical Center, Ann Arbor MI, USA
    Blood 96:4222-6. 2000
  3. doi Heparin rescues factor V Leiden-associated placental failure independent of anticoagulation in a murine high-risk pregnancy model
    Jianzhong An
    Division of Pediatric Pathology, Department of Pathology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Blood 121:2127-34. 2013
  4. doi Endogenous protein C has a protective role during Gram-negative pneumosepsis (melioidosis)
    L M Kager
    Center for Infection and Immunity Amsterdam, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Thromb Haemost 11:282-92. 2013
  5. doi Low but sustained coagulation activation ameliorates glucose-induced podocyte apoptosis: protective effect of factor V Leiden in diabetic nephropathy
    Hongjie Wang
    Department of Medicine I and Clinical Chemistry, University of Heidelberg, Heidelberg, Germany
    Blood 117:5231-42. 2011
  6. ncbi Factor V Leiden and the etiology of inflammatory bowel disease
    C Arnold Spek
    Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Thromb Haemost 98:670-3. 2007
  7. ncbi Factor V Leiden mutation is associated with enhanced arterial thrombotic tendency in lean but not in obese mice
    Nobuo Nagai
    Center for Molecular and Vascular Biology, KU Leuven, Campus Gasthuisberg, O and N 1, Herestraat 49, Box 911, 3000 Leuven, Belgium
    Thromb Haemost 98:858-63. 2007
  8. pmc Protein Z-dependent protease inhibitor deficiency produces a more severe murine phenotype than protein Z deficiency
    Jing Zhang
    Division of Hematology, Washington University, St Louis, MO, USA
    Blood 111:4973-8. 2008
  9. doi Pregnancy-associated changes in the hemostatic system in wild-type and factor V Leiden mice
    S N Tchaikovski
    Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    J Thromb Haemost 7:312-8. 2009
  10. pmc Reduced thrombin generation increases host susceptibility to group A streptococcal infection
    Hongmin Sun
    Department of Internal Medicine, University of Missouri Columbia, USA
    Blood 113:1358-64. 2009

Research Grants

  1. Multidiscplinary Cardiovascular Research Training
    DANIEL EITZMAN; Fiscal Year: 2006
  2. Leptin in Vascular Disease
    DANIEL EITZMAN; Fiscal Year: 2007
  3. Leptin in Vascular Disease
    Daniel T Eitzman; Fiscal Year: 2010

Scientific Experts

  • Liesbeth Martine Kager
  • C A Spek
  • DANIEL EITZMAN
  • Rashmi Sood
  • Marcel Schouten
  • Yue chun Shen
  • David Ginsburg
  • Hongmin Sun
  • Hongjie Wang
  • J Cui
  • Jianzhong An
  • T L Yang
  • D Ginsburg
  • Bin Zhang
  • Peter P Nawroth
  • Berend Isermann
  • Khurrum Shahzad
  • Ilya A Vinnikov
  • Angelika Bierhaus
  • Thati Madhusudhan
  • Muhammed Kashif
  • Tony L Yang
  • Jun Li
  • Makiko Shimosawa
  • Stefanie Seehaus
  • S N Tchaikovski
  • Janka Kisucka
  • Jing Zhang
  • Nobuo Nagai
  • C P W Klerk
  • Yuechun Shen
  • Xixi Wang
  • A Schlachterman
  • Samira B Jeimy
  • Andrew C Parker
  • Angela Yang
  • Magarya S Waitara
  • Brian G Petrich
  • Paula E North
  • Michelle Bordas
  • Vidhyalakshmi Arumugam
  • Uma Sinha
  • Raymond G Hoffmann
  • C T Griffin
  • Tao He
  • Vedat Schwenger
  • Randy Schekman
  • Andrea Baines
  • Sandra Muller-Krebs
  • Gottfried Rudofsky
  • Matthew P Vasievich
  • Simone Schmidt
  • Min Zhu
  • Randal J Kaufman
  • Björn Hummel
  • Jinoh Kim
  • Chunlei Zheng
  • Jiayi Tao
  • Ai lan Chen
  • Xiao Ming Wang
  • Bi Hui Luo
  • Bi ru Ou
  • Z F Yin
  • Ayce Yesilaltay
  • Volker Eckstein
  • Florian Bea
  • Takahiko Ono
  • V Tchaikovski
  • Fumiaki Nogaki
  • G Tans
  • M C L G D Thomassen
  • Bing Qiao Zhao
  • Anil K Chauhan
  • Noriko Mori
  • Martin Schiller
  • Hidetaka Otsuka
  • Dong feng Lu
  • Ian S Patten
  • A C A Cleuren
  • Chao chen Zhao
  • Monty Krieger
  • J Rosing
  • Kohei Kamikado
  • Denisa D Wagner
  • De xi Hu
  • Hisayo Kitamura
  • Hartmut Weiler
  • Koji Sakamoto
  • Jie zhen Pan
  • B J M van Vlijmen

Detail Information

Publications34

  1. doi Hypercoagulability inhibits monocyte transendothelial migration through protease-activated receptor-1-, phospholipase-Cbeta-, phosphoinositide 3-kinase-, and nitric oxide-dependent signaling in monocytes and promotes plaque stability
    Stefanie Seehaus
    Department of Medicine I and Clinical Chemistry, University of Heidelberg, INF 410, 69120 Heidelberg, Germany
    Circulation 120:774-84. 2009
    ..These seemingly opposing data suggest that hypercoagulability might exert both proatherogenic and antiatherogenic effects. We therefore investigated whether hypercoagulability mediates a beneficial effect during de novo atherogenesis...
  2. ncbi Spontaneous thrombosis in mice carrying the factor V Leiden mutation
    J Cui
    Division of Medical Genetics, Department of Human Genetics, University of Michigan Medical Center, Ann Arbor MI, USA
    Blood 96:4222-6. 2000
    ..Blood. 2000;96:4222-4226)..
  3. doi Heparin rescues factor V Leiden-associated placental failure independent of anticoagulation in a murine high-risk pregnancy model
    Jianzhong An
    Division of Pediatric Pathology, Department of Pathology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Blood 121:2127-34. 2013
    ..Importantly, thrombin-mediated maternal platelet activation remains central in the mechanism of placental failure...
  4. doi Endogenous protein C has a protective role during Gram-negative pneumosepsis (melioidosis)
    L M Kager
    Center for Infection and Immunity Amsterdam, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Thromb Haemost 11:282-92. 2013
    ..Inhibition of endogenous APC in endotoxemia and sepsis results in exacerbation of coagulation and inflammation, with consequent enhanced lethality...
  5. doi Low but sustained coagulation activation ameliorates glucose-induced podocyte apoptosis: protective effect of factor V Leiden in diabetic nephropathy
    Hongjie Wang
    Department of Medicine I and Clinical Chemistry, University of Heidelberg, Heidelberg, Germany
    Blood 117:5231-42. 2011
    ..These results identify a nephroprotective function of low but sustained thrombin levels in FVL carriers, supporting a dual, context-dependent function of thrombin in chronic diseases...
  6. ncbi Factor V Leiden and the etiology of inflammatory bowel disease
    C Arnold Spek
    Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Thromb Haemost 98:670-3. 2007
    ..We therefore conclude that the FV Leiden allele has no effect in murine colitis and we thus question the importance of activated blood coagulation in the etiology or pathogenesis of IBD...
  7. ncbi Factor V Leiden mutation is associated with enhanced arterial thrombotic tendency in lean but not in obese mice
    Nobuo Nagai
    Center for Molecular and Vascular Biology, KU Leuven, Campus Gasthuisberg, O and N 1, Herestraat 49, Box 911, 3000 Leuven, Belgium
    Thromb Haemost 98:858-63. 2007
    ....
  8. pmc Protein Z-dependent protease inhibitor deficiency produces a more severe murine phenotype than protein Z deficiency
    Jing Zhang
    Division of Hematology, Washington University, St Louis, MO, USA
    Blood 111:4973-8. 2008
    ..The studies in mice suggest that human PZ and ZPI deficiency would be associated with a modest thrombotic risk with ZPI deficiency producing a more severe phenotype...
  9. doi Pregnancy-associated changes in the hemostatic system in wild-type and factor V Leiden mice
    S N Tchaikovski
    Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    J Thromb Haemost 7:312-8. 2009
    ..Mouse models are often used for preclinical testing of newly developed hormone preparations. However, it is not known whether hormone-induced APC resistance is also observed in laboratory animals...
  10. pmc Reduced thrombin generation increases host susceptibility to group A streptococcal infection
    Hongmin Sun
    Department of Internal Medicine, University of Missouri Columbia, USA
    Blood 113:1358-64. 2009
    ..of FV in either pool resulted in markedly increased mortality after GAS infection, with comparison to heterozygous F5-deficient mice suggesting a previously unappreciated role for the platelet FV pool in host defense...
  11. pmc Elevated levels of soluble P-selectin in mice alter blood-brain barrier function, exacerbate stroke, and promote atherosclerosis
    Janka Kisucka
    Immune Disease Institute, Harvard Medical School, Boston, MA, USA
    Blood 113:6015-22. 2009
    ..Thus, elevated sP-selectin is not only a biomarker for vascular disease, but also may contribute directly to atherosclerosis and cerebrovascular complications...
  12. doi Lipopolysaccharide-triggered acute aggravation of mesangioproliferative glomerulonephritis through activation of coagulation in a high IgA strain of ddY mice
    Makiko Shimosawa
    Division of Molecular Medicine, University of Shizuoka School of Pharmaceutical Sciences, Shizuoka General Hospital, Shizuoka 422 8526, Japan
    Nephron Exp Nephrol 112:e81-91. 2009
    ..In this study, aggravation of glomerulonephritis in HIGA mice through lipopolysaccharide (LPS)-triggered activation of coagulation was investigated...
  13. ncbi [Factor V Leiden mutation leads to enhanced atherosclerosis in apolipoprotein E deficient mice]
    Yue chun Shen
    Department of Cardiology, First Affiliated Hospital, Guangzhou Medical College, Guangzhou 510120, China
    Zhonghua Xin Xue Guan Bing Za Zhi 37:59-62. 2009
    ..We evaluated the effect of FvL mutation on atherosclerosis in apolipoprotein E deficient mice fed with normal diet...
  14. pmc Mice deficient in LMAN1 exhibit FV and FVIII deficiencies and liver accumulation of α1-antitrypsin
    Bin Zhang
    Genomic Medicine Institute, Lerner Research Institute of Cleveland Clinic, Cleveland, OH, USA
    Blood 118:3384-91. 2011
    ....
  15. doi Factor V Leiden mutation does not affect coagulopathy or outcome in lethal H1N1 influenza
    M Schouten
    Center for Experimental and Molecular Medicine, University of Amsterdam, Amsterdam, The Netherlands
    Eur Respir J 36:1346-54. 2010
    ..In conclusion, coagulation is activated locally and systemically during lethal murine influenza A infection. The FVL mutation does not influence coagulation activation, lung inflammation or survival in lethal influenza A...
  16. doi [Synergistic effect of deficiency in thrombosis-related genes]
    Yue chun Shen
    Department of Cardiology, First Affiliated Hospital, Guangzhou Medical College, Guangzhou, Guangdong, 510120 PR China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 27:246-9. 2010
    ..To investigate the interaction of deficiency in thrombosis-related gene in a mouse model...
  17. ncbi Colon cancer metastasis in mouse liver is not affected by hypercoagulability due to Factor V Leiden mutation
    C P W Klerk
    Academic Medical Center, Department of Cell Biology and Histology, University of Amsterdam, The Netherlands
    J Cell Mol Med 11:561-8. 2007
    ..Fibrin deposition and thus inhibition of fibrin formation by anticoagulants do not seem to affect tumour development in this model...
  18. pmc Fetal gene defects precipitate platelet-mediated pregnancy failure in factor V Leiden mothers
    Rashmi Sood
    Blood Research Institute, Blood Center of Wisconsin, Milwaukee, WI 53226, USA
    J Exp Med 204:1049-56. 2007
    ..e., thrombosis or pregnancy loss), depending on the vascular bed in which this interaction occurs...
  19. ncbi Alpha-galactosidase A deficiency leads to increased tissue fibrin deposition and thrombosis in mice homozygous for the factor V Leiden mutation
    Yuechun Shen
    Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI, USA
    Stroke 37:1106-8. 2006
    ..Fabry disease, an X-linked lysosomal storage disorder attributable to alpha-galactosidase A (GLA) deficiency, is associated with premature vascular events that may be thrombotic in nature...
  20. ncbi Assignment of gene for coagulation factor V to chromosome 1 in man and to chromosome 13 in rat
    B Dahlback
    Department of Clinical Chemistry, University of Lund, Malmo General Hospital, Sweden
    Somat Cell Mol Genet 14:509-14. 1988
    ..In the rat, the gene for coagulation factor V was found to be located in chromosome 13. This is the first gene in the rat to be localized to chromosome 13...
  21. ncbi Linkage map of nine loci defined by polymorphic DNA markers assigned to rat chromosome 13
    E F Remmers
    Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892
    Genomics 18:277-82. 1993
    ..An examination of human and mouse comparative map information for all loci assigned to rat chromosome 13 shows significant synteny conservation with the q arm of human chromosome 1 and the distal portion of mouse chromosome 1...
  22. ncbi Fatal haemorrhage and incomplete block to embryogenesis in mice lacking coagulation factor V
    J Cui
    Howard Hughes Medical Institute, University of Michigan Medical School, Ann Arbor, USA
    Nature 384:66-8. 1996
    ....
  23. ncbi FISH mapping of three ammonia metabolism genes (Glul, Cps1, Glud1) in rat, and the chromosomal localization of GLUL in human and Cps1 in mouse
    K Helou
    Department of Genetics, Göteborg University Medicinareg 9C, S 413 90 Göteborg, Sweden
    Mamm Genome 8:362-4. 1997
  24. ncbi The structure and function of murine factor V and its inactivation by protein C
    T L Yang
    Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI 48109 0650, USA
    Blood 91:4593-9. 1998
    ..Thus, the structure and function of FV and its interaction with APC are highly conserved across mammalian species...
  25. ncbi Rescue of fatal neonatal hemorrhage in factor V deficient mice by low level transgene expression
    T L Yang
    Department of Human Genetics, University of Michigan, Ann Arbor, USA
    Thromb Haemost 83:70-7. 2000
    ....
  26. pmc Prothrombotic phenotype of protein Z deficiency
    Z F Yin
    Division of Hematology, Barnes Jewish Hospital at Washington University School of Medicine, 216 South Kingshighway Boulevard, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 97:6734-8. 2000
    ..The results indicate that PZ plays a physiologically important role in the regulation of coagulation...
  27. ncbi A role for thrombin receptor signaling in endothelial cells during embryonic development
    C T Griffin
    Cardiovascular Research Institute, University of California at San Francisco UCSF, San Francisco, California 94143
    Science 293:1666-70. 2001
    ....
  28. ncbi Biosynthetic origin and functional significance of murine platelet factor V
    Tony L Yang
    Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA
    Blood 102:2851-5. 2003
    ....
  29. ncbi The murine platelet and plasma factor V pools are biosynthetically distinct and sufficient for minimal hemostasis
    Hongmin Sun
    Department of Internal Medicine, Division of Molecular Medicine and Genetics, University of Michigan, Ann Arbor, 48109, USA
    Blood 102:2856-61. 2003
    ..In addition, these findings indicate that the murine platelet and plasma FV pools are biosynthetically distinct, in contrast to a previous report demonstrating a plasma origin for platelet FV in humans...
  30. ncbi Identification of the MMRN1 binding region within the C2 domain of human factor V
    Samira B Jeimy
    Health Sciences Centre 2N31, Pathology and Molecular Medicine, McMaster University, 1200 Main Street West, Hamilton, Ontario L8N 3Z5, Canada
    J Biol Chem 279:51466-71. 2004
    ..The dissociation of factor V-multimerin 1 complexes following factor V activation suggests a role for multimerin 1 in delivering and localizing factor V onto platelets prior to prothrombinase assembly...
  31. ncbi Factor VLeiden inhibits fibrinolysis in vivo
    Andrew C Parker
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor 48109 0644, USA
    Circulation 110:3594-8. 2004
    ..Factor V(Leiden) (fV(Leiden)) predisposes to thrombosis by enhancing thrombin formation. This study tested the hypothesis that fV(Leiden) inhibits fibrinolysis in vivo...
  32. ncbi Homozygosity for factor V Leiden leads to enhanced thrombosis and atherosclerosis in mice
    Daniel T Eitzman
    Division of Cardiology, University of Michigan Medical Center, Ann Arbor 48109 0644, USA
    Circulation 111:1822-5. 2005
    ..Although the impact of FVL on the development of venous thrombosis is well established, its effect on arterial thrombosis and atherosclerosis is controversial...
  33. ncbi Factor V Leiden improves in vivo hemostasis in murine hemophilia models
    A Schlachterman
    Divison of Hematology, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    J Thromb Haemost 3:2730-7. 2005
    ..Our observations may partly explain the heterogeneous clinical evidence of the beneficial role of FVL in hemophilia...
  34. pmc Genomic organization of the selectin family of leukocyte adhesion molecules on human and mouse chromosome 1
    M L Watson
    Department of Medicine, Duke University, Durham, North Carolina 27710
    J Exp Med 172:263-72. 1990
    ..These data characterize the organization of a genomic region that may be critical for intercellular communication within the immune system...

Research Grants8

  1. Multidiscplinary Cardiovascular Research Training
    DANIEL EITZMAN; Fiscal Year: 2006
    ..abstract_text> ..
  2. Leptin in Vascular Disease
    DANIEL EITZMAN; Fiscal Year: 2007
    ..These studies will determine the functional in vivo significance of leptin and various leptin receptor pools in vascular disease and have important implications for understanding the effects of obesity on cardiovascular complications. ..
  3. Leptin in Vascular Disease
    Daniel T Eitzman; Fiscal Year: 2010
    ..Results of these studies may identify novel targets for reducing the vascular risk associated with obesity. ..