F3

Summary

Gene Symbol: F3
Description: coagulation factor III
Alias: AA409063, CD142, Cf-3, Cf3, tissue factor
Species: mouse
Products:     F3

Top Publications

  1. Toomey J, Kratzer K, Lasky N, Stanton J, Broze G. Targeted disruption of the murine tissue factor gene results in embryonic lethality. Blood. 1996;88:1583-7 pubmed
    b>Tissue factor (TF) is an integral membrane glycoprotein that is believed to be the physiologic initiator of the blood coagulation cascade. Disruption of the mouse tissue factor gene leads to embryonic lethality between days E9.5-E11...
  2. Sharma L, Melis E, Hickey M, Clyne C, Erlich J, Khachigian L, et al. The cytoplasmic domain of tissue factor contributes to leukocyte recruitment and death in endotoxemia. Am J Pathol. 2004;165:331-40 pubmed
    b>Tissue factor (TF) is an integral membrane protein that binds factor VIIa and initiates coagulation...
  3. Melis E, Moons L, Arnout J, Hoylaerts M, Collen D, Carmeliet P, et al. Thrombophilia in mice expressing a tissue factor variant lacking its transmembrane and cytosolic domain. Biochem Biophys Res Commun. 2005;333:488-95 pubmed
    Mice with a targeted truncation in the gene encoding tissue factor of blood coagulation (TF) to eliminate the cytosolic domain and carrying a neo(R) cassette in intron 5 unexpectedly displayed severe spontaneous thrombosis in various ..
  4. Anthoni C, Russell J, Wood K, Stokes K, Vowinkel T, Kirchhofer D, et al. Tissue factor: a mediator of inflammatory cell recruitment, tissue injury, and thrombus formation in experimental colitis. J Exp Med. 2007;204:1595-601 pubmed
    ..However, it remains unclear whether components of the coagulation pathway, such as tissue factor (TF), contribute to intestinal inflammation, and whether targeting TF will blunt the inflammatory cell ..
  5. Redecha P, Van Rooijen N, Torry D, Girardi G. Pravastatin prevents miscarriages in mice: role of tissue factor in placental and fetal injury. Blood. 2009;113:4101-9 pubmed publisher
    ..CBA/J mice) that shares features with human recurrent miscarriage and fetal growth restriction, we identified tissue factor (TF) as an essential participating factor in placental and fetal injury...
  6. Pawlinski R, Fernandes A, Kehrle B, Pedersen B, Parry G, Erlich J, et al. Tissue factor deficiency causes cardiac fibrosis and left ventricular dysfunction. Proc Natl Acad Sci U S A. 2002;99:15333-8 pubmed
    Exposure of blood to tissue factor (TF) activates the extrinsic (TF:FVIIa) and intrinsic (FVIIIa:FIXa) pathways of coagulation...
  7. Bogdanov V, Kirk R, Miller C, Hathcock J, Vele S, Gazdoiu M, et al. Identification and characterization of murine alternatively spliced tissue factor. J Thromb Haemost. 2006;4:158-67 pubmed
    b>Tissue factor (TF) is a transmembrane glycoprotein that initiates coagulation and plays a critical role in regulating hemostasis and thrombosis...
  8. Schaffner F, Versteeg H, Schillert A, Yokota N, Petersen L, Mueller B, et al. Cooperation of tissue factor cytoplasmic domain and PAR2 signaling in breast cancer development. Blood. 2010;116:6106-13 pubmed publisher
    Constitutive expression of tissue factor (TF) by cancer cells triggers local activation of the coagulation cascade and promotes breast cancer progression through cell signaling involving protease activated receptor (PAR)2...
  9. Sevastos J, Kennedy S, Davis D, Sam M, Peake P, Charlesworth J, et al. Tissue factor deficiency and PAR-1 deficiency are protective against renal ischemia reperfusion injury. Blood. 2007;109:577-83 pubmed
    ..b>Tissue factor (TF) is up-regulated during IR, and TF inhibition reduces renal injury...

More Information

Publications85

  1. Pawlinski R, Pedersen B, Schabbauer G, Tencati M, Holscher T, Boisvert W, et al. Role of tissue factor and protease-activated receptors in a mouse model of endotoxemia. Blood. 2004;103:1342-7 pubmed
    ..In this study, we used both genetic and pharmacologic approaches to analyze the role of tissue factor and protease-activated receptors in coagulation and inflammation in a mouse endotoxemia model...
  2. Carmeliet P, Mackman N, Moons L, Luther T, Gressens P, Van Vlaenderen I, et al. Role of tissue factor in embryonic blood vessel development. Nature. 1996;383:73-5 pubmed
    b>Tissue factor, a member of the cytokine-receptor superfamily and high-affinity receptor and cofactor for plasma factor VII/VIIa (ref. 1), is the primary cellular initiator of blood coagulation...
  3. Pawlinski R, Tencati M, Holscher T, Pedersen B, Voet T, Tilley R, et al. Role of cardiac myocyte tissue factor in heart hemostasis. J Thromb Haemost. 2007;5:1693-700 pubmed
    The tissue-specific pattern of tissue factor (TF) expression suggests that it plays a major role in the hemostatic protection of specific organs, such as the heart and lung...
  4. Redecha P, Tilley R, Tencati M, Salmon J, Kirchhofer D, Mackman N, et al. Tissue factor: a link between C5a and neutrophil activation in antiphospholipid antibody induced fetal injury. Blood. 2007;110:2423-31 pubmed
    ..In this study, we analyzed the role of the procoagulant molecule tissue factor (TF) in a mouse model of aPL antibody-induced pregnancy loss...
  5. Mackman N. Role of tissue factor in hemostasis, thrombosis, and vascular development. Arterioscler Thromb Vasc Biol. 2004;24:1015-22 pubmed
    b>Tissue factor (TF) is best known as the primary cellular initiator of blood coagulation. After vessel injury, the TF:FVIIa complex activates the coagulation protease cascade, which leads to fibrin deposition and activation of platelets...
  6. Day S, Reeve J, Pedersen B, Farris D, Myers D, Im M, et al. Macrovascular thrombosis is driven by tissue factor derived primarily from the blood vessel wall. Blood. 2005;105:192-8 pubmed
    Leukocytes and leukocyte-derived microparticles contain low levels of tissue factor (TF) and incorporate into forming thrombi...
  7. Parry G, Erlich J, Carmeliet P, Luther T, Mackman N. Low levels of tissue factor are compatible with development and hemostasis in mice. J Clin Invest. 1998;101:560-9 pubmed
    b>Tissue factor (TF) expression is associated with life-threatening thrombosis in a variety of human diseases, including sepsis, cancer, and atherosclerosis...
  8. van den Berg Y, van den Hengel L, Myers H, Ayachi O, Jordanova E, Ruf W, et al. Alternatively spliced tissue factor induces angiogenesis through integrin ligation. Proc Natl Acad Sci U S A. 2009;106:19497-502 pubmed publisher
    The initiator of coagulation, full-length tissue factor (flTF), in complex with factor VIIa, influences angiogenesis through PAR-2...
  9. Melis E, Moons L, De Mol M, Herbert J, Mackman N, Collen D, et al. Targeted deletion of the cytosolic domain of tissue factor in mice does not affect development. Biochem Biophys Res Commun. 2001;286:580-6 pubmed
    The role of the cytosolic domain of tissue factor (TF) in signal transduction and gene regulation was studied in mice with a targeted deletion of the 18 carboxy-terminal intracellular amino acids...
  10. Li W, Zheng X, Gu J, Ferrell G, Brady M, Esmon N, et al. Extraembryonic expression of EPCR is essential for embryonic viability. Blood. 2005;106:2716-22 pubmed
    ..In genetically modified mice with low tissue factor activity, Procr deficiency is not lethal to the embryo...
  11. Falati S, Liu Q, Gross P, Merrill Skoloff G, Chou J, Vandendries E, et al. Accumulation of tissue factor into developing thrombi in vivo is dependent upon microparticle P-selectin glycoprotein ligand 1 and platelet P-selectin. J Exp Med. 2003;197:1585-98 pubmed
    ..We observe P-selectin expression, tissue factor accumulation, and fibrin generation after platelet localization in the developing thrombus in arterioles of ..
  12. Luther T, Flössel C, Mackman N, Bierhaus A, Kasper M, Albrecht S, et al. Tissue factor expression during human and mouse development. Am J Pathol. 1996;149:101-13 pubmed
    In the adult organism the cellular distribution of tissue factor (TF) expression corresponds to biological boundary layers forming a hemostatic barrier ready to activate blood coagulation after tissue injury...
  13. Clark C, Vatsyayan R, Hedner U, Esmon C, Pendurthi U, Rao L. Endothelial cell protein C receptor-mediated redistribution and tissue-level accumulation of factor VIIa. J Thromb Haemost. 2012;10:2383-91 pubmed publisher
  14. Bugge T, Xiao Q, Kombrinck K, Flick M, Holmbäck K, Danton M, et al. Fatal embryonic bleeding events in mice lacking tissue factor, the cell-associated initiator of blood coagulation. Proc Natl Acad Sci U S A. 1996;93:6258-63 pubmed
    b>Tissue factor (TF) is the cellular receptor for coagulation factor VI/VIIa and is the membrane-bound glycoprotein that is generally viewed as the primary physiological initiator of blood coagulation...
  15. Redecha P, Franzke C, Ruf W, Mackman N, Girardi G. Neutrophil activation by the tissue factor/Factor VIIa/PAR2 axis mediates fetal death in a mouse model of antiphospholipid syndrome. J Clin Invest. 2008;118:3453-61 pubmed publisher
    ..We have previously shown that C5a induction of tissue factor (TF) expression in neutrophils contributes to respiratory burst, trophoblast injury, and pregnancy loss in ..
  16. Pawlinski R, Wang J, Owens A, Williams J, Antoniak S, Tencati M, et al. Hematopoietic and nonhematopoietic cell tissue factor activates the coagulation cascade in endotoxemic mice. Blood. 2010;116:806-14 pubmed publisher
    b>Tissue factor (TF) is the primary activator of the coagulation cascade. During endotoxemia, TF expression leads to disseminated intravascular coagulation...
  17. Ahamed J, Niessen F, Kurokawa T, Lee Y, Bhattacharjee G, Morrissey J, et al. Regulation of macrophage procoagulant responses by the tissue factor cytoplasmic domain in endotoxemia. Blood. 2007;109:5251-9 pubmed
    b>Tissue factor (TF) is the primary initiator of coagulation, and the TF pathway mediates signaling through protease-activated receptors (PARs)...
  18. Falati S, Gross P, Merrill Skoloff G, Furie B, Furie B. Real-time in vivo imaging of platelets, tissue factor and fibrin during arterial thrombus formation in the mouse. Nat Med. 2002;8:1175-81 pubmed
    ..We observed platelet deposition, tissue factor accumulation and fibrin generation after laser-induced endothelial injury in a single developing thrombus...
  19. Godby R, van den Berg Y, Srinivasan R, Sturm R, Hui D, Konieczny S, et al. Nonproteolytic properties of murine alternatively spliced tissue factor: implications for integrin-mediated signaling in murine models. Mol Med. 2012;18:771-9 pubmed publisher
    This study was performed to determine whether murine alternatively spliced tissue factor (masTF) acts analogously to human alternatively spliced tissue factor (hasTF) in promoting neovascularization via integrin ligation...
  20. Schoenmakers S, Groot A, Florquin S, Reitsma P, Spek C. Blood cell-derived tissue factor influences host response during murine endotoxemia. Blood Cells Mol Dis. 2004;32:325-33 pubmed
    During endotoxemia, blood coagulation becomes activated due to tissue factor (TF) expression on leukocytes and/or endothelial cells. We investigated the influence of blood cell-derived tissue factor on murine endotoxemia...
  21. Snyder L, Rudnick K, Tawadros R, Volk A, Tam S, Anderson G, et al. Expression of human tissue factor under the control of the mouse tissue factor promoter mediates normal hemostasis in knock-in mice. J Thromb Haemost. 2008;6:306-14 pubmed
    b>Tissue factor (TF) is expressed widely at the subluminal surface of blood vessels and serves as the primary cellular initiator of the extrinsic pathway of blood coagulation...
  22. Luyendyk J, Sullivan B, Guo G, Wang R. Tissue factor-deficiency and protease activated receptor-1-deficiency reduce inflammation elicited by diet-induced steatohepatitis in mice. Am J Pathol. 2010;176:177-86 pubmed publisher
    ..We tested the hypothesis that tissue factor (TF)-dependent thrombin generation and the thrombin receptor protease activated receptor-1 (PAR-1) contribute ..
  23. Boltzen U, Eisenreich A, Antoniak S, Weithaeuser A, Fechner H, Poller W, et al. Alternatively spliced tissue factor and full-length tissue factor protect cardiomyocytes against TNF-?-induced apoptosis. J Mol Cell Cardiol. 2012;52:1056-65 pubmed publisher
    b>Tissue Factor (TF) is expressed in various cell types of the heart, such as cardiomyocytes. In addition to its role in the initiation of blood coagulation, the TF:FVIIa complex protects cells from apoptosis...
  24. Sluka S, Akhmedov A, Vogel J, Unruh D, Bogdanov V, Camici G, et al. Alternatively spliced tissue factor is not sufficient for embryonic development. PLoS ONE. 2014;9:e97793 pubmed publisher
    b>Tissue factor (TF) triggers blood coagulation and is translated from two mRNA splice isoforms, encoding membrane-anchored full-length TF (flTF) and soluble alternatively-spliced TF (asTF)...
  25. Li F, Wang C, Wang J, Thai T, Boysen G, Xu L, et al. Elevated tissue factor expression contributes to exacerbated diabetic nephropathy in mice lacking eNOS fed a high fat diet. J Thromb Haemost. 2010;8:2122-32 pubmed publisher
    ..Lack of nitric oxide and fatty acids stimulates the NF-kB pathway, which increases tissue factor (TF)...
  26. Shaver C, Grove B, Putz N, Clune J, Lawson W, Carnahan R, et al. Regulation of alveolar procoagulant activity and permeability in direct acute lung injury by lung epithelial tissue factor. Am J Respir Cell Mol Biol. 2015;53:719-27 pubmed publisher
    b>Tissue factor (TF) initiates the extrinsic coagulation cascade in response to tissue injury, leading to local fibrin deposition...
  27. Shaver C, Grove B, Clune J, Mackman N, Ware L, Bastarache J. Myeloid tissue factor does not modulate lung inflammation or permeability during experimental acute lung injury. Sci Rep. 2016;6:22249 pubmed publisher
    b>Tissue factor (TF) is a critical mediator of direct acute lung injury (ALI) with global TF deficiency resulting in increased airspace inflammation, alveolar-capillary permeability, and alveolar hemorrhage after intra-tracheal ..
  28. Solovey A, Kollander R, Milbauer L, Abdulla F, Chen Y, Kelm R, et al. Endothelial nitric oxide synthase and nitric oxide regulate endothelial tissue factor expression in vivo in the sickle transgenic mouse. Am J Hematol. 2010;85:41-5 pubmed publisher
    ..The sickle transgenic mouse abnormally expresses tissue factor (TF) on the pulmonary vein endothelium...
  29. Chou J, Mackman N, Merrill Skoloff G, Pedersen B, Furie B, Furie B. Hematopoietic cell-derived microparticle tissue factor contributes to fibrin formation during thrombus propagation. Blood. 2004;104:3190-7 pubmed
    b>Tissue factor (TF) is expressed on nonvascular cells and cells within the vessel wall and circulates in blood associated with microparticles...
  30. McDonald A, Yang K, Roberts H, Monroe D, Hoffman M. Perivascular tissue factor is down-regulated following cutaneous wounding: implications for bleeding in hemophilia. Blood. 2008;111:2046-8 pubmed
    ..HB mice do not bleed excessively at wounding, yet rebleed hours to days later. Tissue factor (TF) expression is up-regulated by inflammatory cytokines and has been linked to angiogenesis...
  31. Lay A, Northway C, Donahue D, Castellino F. Low levels of tissue factor rescue protein C-associated pregnancy failure in mice. J Thromb Haemost. 2008;6:1815-7 pubmed publisher
  32. Iqbal M, Johns M, Cao J, Liu Y, Yu S, Hyde G, et al. PARP-14 combines with tristetraprolin in the selective posttranscriptional control of macrophage tissue factor expression. Blood. 2014;124:3646-55 pubmed publisher
    b>Tissue factor (TF) (CD142) is a 47 kDa transmembrane cell surface glycoprotein that triggers the extrinsic coagulation cascade and links thrombosis with inflammation...
  33. von Brühl M, Stark K, Steinhart A, Chandraratne S, Konrad I, Lorenz M, et al. Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo. J Exp Med. 2012;209:819-35 pubmed publisher
    ..and bone marrow chimeras, we show that intravascular activation of the extrinsic pathway of coagulation via tissue factor (TF) derived from myeloid leukocytes causes the extensive intraluminal fibrin formation characteristic of DVT...
  34. Kral Pointner J, Schrottmaier W, Horvath V, Datler H, Hell L, Ay C, et al. Myeloid but not epithelial tissue factor exerts protective anti-inflammatory effects in acid aspiration-induced acute lung injury. J Thromb Haemost. 2017;15:1625-1639 pubmed publisher
    Essentials Tissue factor (TF) represents a central link between hemostasis and inflammation. We studied the roles of myeloid and airway epithelial TF in acid-caused acute lung injury (ALI)...
  35. Sheerin N, Springall T, Carroll M, Hartley B, Sacks S. Protection against anti-glomerular basement membrane (GBM)-mediated nephritis in C3- and C4-deficient mice. Clin Exp Immunol. 1997;110:403-9 pubmed
    ..These studies support a critical role for complement in the development of anti-GBM disease. However, the protective effect of complement deficiency can be broken if the dose of nephritogenic antibody is increased. ..
  36. Liang H, Kerschen E, Hernandez I, Basu S, Zogg M, Botros F, et al. EPCR-dependent PAR2 activation by the blood coagulation initiation complex regulates LPS-triggered interferon responses in mice. Blood. 2015;125:2845-54 pubmed publisher
    ..the blood coagulation mechanism, secondary to the inflammation-induced expression of the coagulation initiator tissue factor (TF) on innate immune cells...
  37. Chantrathammachart P, Mackman N, Sparkenbaugh E, Wang J, Parise L, Kirchhofer D, et al. Tissue factor promotes activation of coagulation and inflammation in a mouse model of sickle cell disease. Blood. 2012;120:636-46 pubmed publisher
    ..Here, we examined the role of tissue factor (TF) in the activation of coagulation and inflammation in 2 different mouse models of SCD (BERK and Townes)...
  38. Sullivan B, Kopec A, Joshi N, Cline H, Brown J, Bishop S, et al. Hepatocyte tissue factor activates the coagulation cascade in mice. Blood. 2013;121:1868-74 pubmed publisher
    In this study, we characterized tissue factor (TF) expression in mouse hepatocytes (HPCs) and evaluated its role in mouse models of HPC transplantation and acetaminophen (APAP) overdose...
  39. Subramaniam S, Jurk K, Hobohm L, Jäckel S, Saffarzadeh M, Schwierczek K, et al. Distinct contributions of complement factors to platelet activation and fibrin formation in venous thrombus development. Blood. 2017;129:2291-2302 pubmed publisher
    ..Here we show in a tissue factor (TF)-dependent model of flow restriction-induced venous thrombosis that complement factors make distinct ..
  40. Pedersen B, Holscher T, Sato Y, Pawlinski R, Mackman N. A balance between tissue factor and tissue factor pathway inhibitor is required for embryonic development and hemostasis in adult mice. Blood. 2005;105:2777-82 pubmed
    Inactivation of the murine tissue factor (TF) gene or tissue factor pathway inhibitor 1 (TFPI) gene results in embryonic lethality, indicating that both are required for embryonic development...
  41. Ivanciu L, Krishnaswamy S, Camire R. New insights into the spatiotemporal localization of prothrombinase in vivo. Blood. 2014;124:1705-14 pubmed publisher
    ..Rather, the damaged/activated endothelium and possibly other blood cells play an unexpectedly important role in providing a procoagulant membrane surface in vivo. ..
  42. Westrick R, Tomberg K, Siebert A, Zhu G, Winn M, Dobies S, et al. Sensitized mutagenesis screen in Factor V Leiden mice identifies thrombosis suppressor loci. Proc Natl Acad Sci U S A. 2017;114:9659-9664 pubmed publisher
    ..mice homozygous for F5L (F5L/L ) and haploinsufficient for tissue factor pathway inhibitor (Tfpi+/- )...
  43. Brüggemann L, Drijfhout J, Reitsma P, Spek C. Alternatively spliced tissue factor in mice: induction by Streptococcus pneumoniae. J Thromb Haemost. 2006;4:918-20 pubmed
  44. Yamamoto K, Loskutoff D, Saito H. Renal expression of fibrinolytic genes and tissue factor in a murine model of renal disease as a function of age. Semin Thromb Hemost. 1998;24:261-8 pubmed
    ..plasminogen activators (t-PA and u-PA) and their specific inhibitor (PAI-1)] and of the procoagulant molecule tissue factor (TF), has been reported in various types of renal diseases...
  45. Girardi G. Role of tissue factor in pregnancy complications: crosstalk between coagulation and inflammation. Thromb Res. 2011;127 Suppl 3:S43-6 pubmed publisher
    ..We identified tissue factor (TF) as a crucial mediator of fetal and placental damage in mouse models of recurrent miscarriages and ..
  46. Luyendyk J, Flanagan K, Williams C, Jaeschke H, Slusser J, Mackman N, et al. Tissue factor contributes to neutrophil CD11b expression in alpha-naphthylisothiocyanate-treated mice. Toxicol Appl Pharmacol. 2011;250:256-62 pubmed publisher
    ..by injury to intrahepatic bile ducts and the progression of hepatic necrosis requires the procoagulant protein tissue factor (TF) and extrahepatic cells including neutrophils...
  47. Tilley R, Pedersen B, Pawlinski R, Sato Y, Erlich J, Shen Y, et al. Atherosclerosis in mice is not affected by a reduction in tissue factor expression. Arterioscler Thromb Vasc Biol. 2006;26:555-62 pubmed
    To determine whether tissue factor (TF) contributes to the progression of atherosclerotic lesions in mice...
  48. Palumbo J, Talmage K, Massari J, La Jeunesse C, Flick M, Kombrinck K, et al. Tumor cell-associated tissue factor and circulating hemostatic factors cooperate to increase metastatic potential through natural killer cell-dependent and-independent mechanisms. Blood. 2007;110:133-41 pubmed
    Tumor cell-associated tissue factor (TF) is a powerful determinant of metastatic potential...
  49. Sullivan B, Weinreb P, Violette S, Luyendyk J. The coagulation system contributes to alphaVbeta6 integrin expression and liver fibrosis induced by cholestasis. Am J Pathol. 2010;177:2837-49 pubmed publisher
    ..We tested the hypothesis that tissue factor (TF)-dependent thrombin generation and protease activated receptor-1 (PAR-1) activation contribute to liver ..
  50. Cho Y, Cao X, Shen D, Tuo J, Parver L, Rickles F, et al. Evidence for enhanced tissue factor expression in age-related macular degeneration. Lab Invest. 2011;91:519-26 pubmed publisher
    b>Tissue factor (TF) is the primary initiator of blood coagulation...
  51. Vatsyayan R, Kothari H, Mackman N, Pendurthi U, Rao L. Inactivation of factor VIIa by antithrombin in vitro, ex vivo and in vivo: role of tissue factor and endothelial cell protein C receptor. PLoS ONE. 2014;9:e103505 pubmed publisher
    ..However, in vitro studies showed that AT could inhibit FVIIa effectively only when it was bound to tissue factor (TF). Circulating blood is known to contain only traces of TF, at best...
  52. Soifer S, Peters K, O KEEFE J, Coughlin S. Disparate temporal expression of the prothrombin and thrombin receptor genes during mouse development. Am J Pathol. 1994;144:60-9 pubmed
    ..its zymogen prothrombin at sites of vascular injury when circulating coagulation factors meet extravascular tissue factor. In this context thrombin's varied actions may mediate responses to wounding...
  53. Darbousset R, Thomas G, Mezouar S, Frere C, Bonier R, Mackman N, et al. Tissue factor-positive neutrophils bind to injured endothelial wall and initiate thrombus formation. Blood. 2012;120:2133-43 pubmed publisher
    ..The kinetics of thrombus formation and fibrin generation were drastically reduced in low tissue factor (TF) mice whereas the absence of factor XII had no effect. In vitro, TF was detected in neutrophils...
  54. Johnson B, Brooks B, Heinzmann C, Diep A, Mohandas T, Sparkes R, et al. The Ah receptor nuclear translocator gene (ARNT) is located on q21 of human chromosome 1 and on mouse chromosome 3 near Cf-3. Genomics. 1993;17:592-8 pubmed
    ..The results indicate that the mouse gene resides about 40 cM from the centromere and about 10 cM proximal to Cf-3, the gene for tissue factor.
  55. Erlich J, Parry G, Fearns C, Muller M, Carmeliet P, Luther T, et al. Tissue factor is required for uterine hemostasis and maintenance of the placental labyrinth during gestation. Proc Natl Acad Sci U S A. 1999;96:8138-43 pubmed
    We employed a novel mouse line that expresses low levels of human tissue factor (TF) in the absence of murine TF to analyze the role of TF in gestation...
  56. Owens A, Passam F, Antoniak S, Marshall S, McDaniel A, Rudel L, et al. Monocyte tissue factor-dependent activation of coagulation in hypercholesterolemic mice and monkeys is inhibited by simvastatin. J Clin Invest. 2012;122:558-68 pubmed publisher
    ..elevated levels of oxidized LDL (oxLDL) in plasma and that this induces expression of the procoagulant protein tissue factor (TF) in monocytes...
  57. Tong M, Jiang H, Liu P, Lawson J, Brass L, Song W. Spontaneous fetal loss caused by placental thrombosis in estrogen sulfotransferase-deficient mice. Nat Med. 2005;11:153-9 pubmed
    ..phenotype was associated with elevated free estrogen levels systemically and in the amniotic fluid, increased tissue factor expression in the placenta and heightened platelet sensitivity to agonist-induced activation ex vivo...
  58. Wu Y, V Nguyen A, Wu X, Loh M, Vu M, Zou Y, et al. Antiphospholipid antibodies promote tissue factor-dependent angiogenic switch and tumor progression. Am J Pathol. 2014;184:3359-75 pubmed publisher
    ..with aPL-positive IgG expressed multiple proangiogenic genes, including vascular endothelial growth factor, tissue factor (TF), and colony-stimulating factor 1...
  59. Davis D, Wilson K, Sam M, Kennedy S, Mackman N, Charlesworth J, et al. The development of cardiac fibrosis in low tissue factor mice is gender-dependent and is associated with differential regulation of urokinase plasminogen activator. J Mol Cell Cardiol. 2007;42:559-71 pubmed
    b>Tissue factor (TF) initiates the protease coagulation cascade in response to tissue injury. Homozygous deficiency of murine TF results in embryonic lethality, which is rescued by low-level expression of human TF...
  60. Li Q, Zhang J, Li W, Zou P. [Pathogenetic role of tissue factor in endothelial-injury in graft-versus-host disease]. Zhonghua Xue Ye Xue Za Zhi. 2009;30:610-4 pubmed
    To study the pathogenetic role of tissue factor (TF) in endothelial-injury in GVHD...
  61. Yu J, May L, Milsom C, Anderson G, Weitz J, Luyendyk J, et al. Contribution of host-derived tissue factor to tumor neovascularization. Arterioscler Thromb Vasc Biol. 2008;28:1975-81 pubmed publisher
    The role of host-derived tissue factor (TF) in tumor growth, angiogenesis, and metastasis has hitherto been unclear and was investigated in this study...
  62. Wu J, Stevenson M, Brown J, Grunz E, Strawn T, Fay W. C-reactive protein enhances tissue factor expression by vascular smooth muscle cells: mechanisms and in vivo significance. Arterioscler Thromb Vasc Biol. 2008;28:698-704 pubmed publisher
    We examined the impact of C-reactive protein (CRP) on vascular smooth muscle cell (VSMC) expression of tissue factor (TF) and TF pathway inhibitor (TFPI)...
  63. Robins R, Lemarié C, Laurance S, Aghourian M, Wu J, Blostein M. Vascular Gas6 contributes to thrombogenesis and promotes tissue factor up-regulation after vessel injury in mice. Blood. 2013;121:692-9 pubmed publisher
    ..b>Tissue factor expression was significantly reduced in the vascular wall of Gas6(-/-) mice compared with WT...
  64. Hampton A, Diaz J, Hawley A, Wrobleski S, Wang J, Lee R, et al. Myeloid cell tissue factor does not contribute to venous thrombogenesis in an electrolytic injury model. Thromb Res. 2012;130:640-5 pubmed publisher
    b>Tissue factor (TF) is a potent initiator of the extrinsic coagulation cascade. The role and source of TF in venous thrombotic disease is not clearly defined...
  65. Monroe D, Mackman N, Hoffman M. Wound healing in hemophilia B mice and low tissue factor mice. Thromb Res. 2010;125 Suppl 1:S74-7 pubmed publisher
    ..We have studied wound healing in mice with defects in both the initiation (low tissue factor) and propagation (hemophilia B) phases...
  66. Ranganathan G, Blatti S, Subramaniam M, Fass D, Maihle N, Getz M. Cloning of murine tissue factor and regulation of gene expression by transforming growth factor type beta 1. J Biol Chem. 1991;266:496-501 pubmed
    ..mRNA from AKR-2B murine fibroblasts which encodes a protein with significant sequence similarity to human tissue factor, a cellular initiator of the blood coagulation cascade...
  67. Chen J, Kasper M, Heck T, Nakagawa K, Humpert P, Bai L, et al. Tissue factor as a link between wounding and tissue repair. Diabetes. 2005;54:2143-54 pubmed
    The initial phase of wound repair involves inflammation, induction of tissue factor (TF), formation of a fibrin matrix, and growth of new smooth muscle actin (alpha-SMA)-positive vessels...
  68. Yang Y, Hall P, Milenkovski G, Sharma L, Hutchinson P, Melis E, et al. Reduction in arthritis severity and modulation of immune function in tissue factor cytoplasmic domain mutant mice. Am J Pathol. 2004;164:109-17 pubmed
    b>Tissue factor (TF), a transmembrane receptor for plasma factor VII(a), is the main initiator of the coagulation cascade. It has also been implicated in noncoagulant processes, including inflammation...
  69. Prashar P, Yadav P, Samarjeet F, Bandyopadhyay A. Microarray meta-analysis identifies evolutionarily conserved BMP signaling targets in developing long bones. Dev Biol. 2014;389:192-207 pubmed publisher
  70. Park D, Lyu J, Kim J, Chin H, Bae Y, Baek S. Role of JAK2-STAT3 in TLR2-mediated tissue factor expression. J Cell Biochem. 2013;114:1315-21 pubmed publisher
    b>Tissue factor (TF) is a core protein with an essential function in the coagulation cascade that maintains the homeostasis of the blood vessels...
  71. Wang J, Geddings J, Aleman M, Cardenas J, Chantrathammachart P, Williams J, et al. Tumor-derived tissue factor activates coagulation and enhances thrombosis in a mouse xenograft model of human pancreatic cancer. Blood. 2012;119:5543-52 pubmed publisher
    ..In the present study, we analyzed tissue factor (TF) expression in 4 different human pancreatic tumor cell lines for the purpose of producing derivative ..
  72. Ravassa S, Bennaghmouch A, Kenis H, Lindhout T, Hackeng T, Narula J, et al. Annexin A5 down-regulates surface expression of tissue factor: a novel mechanism of regulating the membrane receptor repertoir. J Biol Chem. 2005;280:6028-35 pubmed
    ..In this study we report the regulation of surface expression of the initiator of blood coagulation tissue factor (TF) by this novel pathway of cell entry...
  73. Rothmeier A, Marchese P, Langer F, Kamikubo Y, Schaffner F, Cantor J, et al. Tissue Factor Prothrombotic Activity Is Regulated by Integrin-arf6 Trafficking. Arterioscler Thromb Vasc Biol. 2017;37:1323-1331 pubmed publisher
    Coagulation initiation by tissue factor (TF) is regulated by cellular inhibitors, cell surface availability of procoagulant phosphatidylserine, and thiol-disulfide exchange...
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    b>Tissue factor is a cellular membrane glycoprotein that acts as a cofactor for Factor VIIa-catalyzed activation of Factors X and IX in the extrinsic blood coagulation pathway...
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    ..vascular effects of either ticagrelor or clopidogrel with focus on arterial thrombosis and its key trigger tissue factor have not been previously investigated...
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    ..These results reveal multiple roles for MEF2C in vascular development and suggest that MEF2-dependent target genes mediate endothelial cell organization and SMC differentiation. ..