Gene Symbol: Eya3
Description: EYA transcriptional coactivator and phosphatase 3
Alias: AI844637, eyes absent homolog 3, eyes absent 3 homolog
Species: mouse
Products:     Eya3

Top Publications

  1. Ohto H, Kamada S, Tago K, Tominaga S, Ozaki H, Sato S, et al. Cooperation of six and eya in activation of their target genes through nuclear translocation of Eya. Mol Cell Biol. 1999;19:6815-24 pubmed
    ..Coexpression of Six2, Six4, or Six5 induced nuclear translocation of Eya1, Eya2, and Eya3, which were otherwise distributed in the cytoplasm...
  2. Xu P, Woo I, Her H, Beier D, Maas R. Mouse Eya homologues of the Drosophila eyes absent gene require Pax6 for expression in lens and nasal placode. Development. 1997;124:219-31 pubmed
    We have identified and mapped three members of a new family of vertebrate genes, designated Eya1, Eya2 and Eya3, which share high sequence similarity with the Drosophila eyes absent (eya) gene...
  3. Borsani G, DeGrandi A, Ballabio A, Bulfone A, Bernard L, Banfi S, et al. EYA4, a novel vertebrate gene related to Drosophila eyes absent. Hum Mol Genet. 1999;8:11-23 pubmed
    ..On the basis of map position and expression pattern, EYA4 is a candidate for oculo-dento-digital (ODD) syndrome, but no EYA4 mutations were found in a panel of ODD patients. ..
  4. Li X, Oghi K, Zhang J, Krones A, Bush K, Glass C, et al. Eya protein phosphatase activity regulates Six1-Dach-Eya transcriptional effects in mammalian organogenesis. Nature. 2003;426:247-54 pubmed
  5. Rayapureddi J, Kattamuri C, Steinmetz B, Frankfort B, Ostrin E, Mardon G, et al. Eyes absent represents a class of protein tyrosine phosphatases. Nature. 2003;426:295-8 pubmed
    ..Furthermore, the phosphatase activity of Eyes absent contributes to its ability to induce eye formation in Drosophila. ..
  6. Tootle T, Silver S, Davies E, Newman V, Latek R, Mills I, et al. The transcription factor Eyes absent is a protein tyrosine phosphatase. Nature. 2003;426:299-302 pubmed
  7. Duncan M, Kos L, Jenkins N, Gilbert D, Copeland N, Tomarev S. Eyes absent: a gene family found in several metazoan phyla. Mamm Genome. 1997;8:479-85 pubmed
    ..Like members of the Pax-6 gene family, eyes absent gene family members were probably first involved in functions not related to vision, with recruitment for visual system formation and function occurring later. ..
  8. Clark S, Fee B, Cleveland J. Misexpression of the eyes absent family triggers the apoptotic program. J Biol Chem. 2002;277:3560-7 pubmed
    ..fmk, suggesting that mitochondria are a major target in Eya-induced apoptosis. These results support the concept that inappropriate changes in the steady state levels of Eya proteins may trigger programmed cell deaths during development. ..
  9. Zhang H, Stavnezer E. Ski regulates muscle terminal differentiation by transcriptional activation of Myog in a complex with Six1 and Eya3. J Biol Chem. 2009;284:2867-79 pubmed publisher
    ..Activation of the MEF3 site required direct interaction of Ski with Six1 and Eya3 mediated by the evolutionarily conserved Dachshund homology domain of Ski...

More Information


  1. Masumoto K, Ukai Tadenuma M, Kasukawa T, Nagano M, Uno K, Tsujino K, et al. Acute induction of Eya3 by late-night light stimulation triggers TSH? expression in photoperiodism. Curr Biol. 2010;20:2199-206 pubmed publisher
    ..we searched for candidate upstream genes by looking for expression that preceded TSH?'s, and we identified the Eya3 gene...
  2. Zimmerman J, Bui Q, Steingrimsson E, Nagle D, Fu W, Genin A, et al. Cloning and characterization of two vertebrate homologs of the Drosophila eyes absent gene. Genome Res. 1997;7:128-41 pubmed
    ..Our findings support the notion that several families of genes (Pax-6/eyeless, Six-3/sine oculis, and Eya) play related and critical roles in the eye for both files and vertebrates. ..
  3. Ikeda K, Watanabe Y, Ohto H, Kawakami K. Molecular interaction and synergistic activation of a promoter by Six, Eya, and Dach proteins mediated through CREB binding protein. Mol Cell Biol. 2002;22:6759-66 pubmed
    ..Recruitment of CBP to the immobilized chromatin DNA template was dependent on FLAG-Dach and GAL4-Eya3. These results indicate that CBP is a mediator of the interaction between Eya and Dach...
  4. Herron B, Liddell R, Parker A, Grant S, Kinne J, Fisher J, et al. A mutation in stratifin is responsible for the repeated epilation (Er) phenotype in mice. Nat Genet. 2005;37:1210-2 pubmed
    ..Er/+ mice expressed a truncated Sfn protein, which probably contributes to the defects in Er/Er and Er/+ epidermis and to cancer development in Er/+ mice. ..
  5. Soker T, Dalke C, Puk O, Floss T, Becker L, Bolle I, et al. Pleiotropic effects in Eya3 knockout mice. BMC Dev Biol. 2008;8:118 pubmed publisher
    ..The functions of its mammalian orthologs Eya1-4 are only partially understood and no mouse model exists for Eya3. Therefore, we characterized the phenotype of a new Eya3 knockout mouse mutant...
  6. Cook P, Ju B, Telese F, Wang X, Glass C, Rosenfeld M. Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions. Nature. 2009;458:591-6 pubmed publisher
  7. Sano T, Nagata S. Characterization of the threonine-phosphatase of mouse eyes absent 3. FEBS Lett. 2011;585:2714-9 pubmed publisher
    ..Using various mutants of mouse EYA3, we showed that the 68-amino acid domain between positions 53 and 120 was necessary and sufficient for its ..