Research Topics
| Exoc6SummaryGene Symbol: Exoc6 Description: exocyst complex component 6 Alias: 4833405E05Rik, AW413330, C430002C19, Sec15, Sec15l1, hbd, msec15, SEC15 homolog, SEC15-like 1, SEC15-like protein 1, exocyst complex component Sec15A Species: mouse Publications Hemoglobin deficit: an inherited hypochromic anemia in the mouseR M Bannerman Proc Soc Exp Biol Med 182:52-7 Loss of rapid transferrin receptor recycling due to a mutation in Sec15l1 in hbd miceMichael D Garrick Department of Biochemistry, School of Medicine and Biomedical Sciences, SUNY, Buffalo, NY 14214, USA Biochim Biophys Acta 1773:105-8 The anemia of "haemoglobin-deficit" (hbd/hbd) mice is caused by a defect in transferrin cyclingAn Sheng Zhang Department of Cellular and Developmental Biology, Oregon Health and Science University, Portland, Ore, USA Exp Hematol 34:593-8 Iron metabolism mutant hbd mice have a deletion in Sec15l1, which has homology to a yeast gene for vesicle dockingRobert A White Department of Medical Research, Children s Mercy Hospitals and Clinics, and Department of Pediatrics Genetics, University of Missouri at Kansas City School of Medicine, Kansas City, MO 64108, USA Genomics 86:668-73 Iron metabolism in the hemoglobin-deficit mouse: correlation of diferric transferrin with hepcidin expressionSarah J Wilkins Iron Metabolism Laboratory, The Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane, Queensland 4029, Australia Blood 107:1659-64 A mutation in Sec15l1 causes anemia in hemoglobin deficit (hbd) miceJackie E Lim Division of Hematology Oncology, Children s Hospital Boston, Karp Family Research Laboratories RM 8 125, Boston, Massachusetts 02115 5737, USA Nat Genet 37:1270-3 B-cell deficiency and reduced B-cell reconstitution in hemoglobin-deficit miceKaren Lipovsky Hematology Branch, National Heart, Lung, and Blood Institute NIH, Building 10 Room 7C118, 9000 Rockville Pike, Bethesda, MD 20892 1652, USA Exp Hematol 31:1230-6 Activation of Hex and mEg5 by retroviral insertion may contribute to mouse B-cell leukemiaG M Hansen Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA Oncogene 18:6531-9 The hemoglobin-deficit mouse: cure of the anemia following bone marrow transplantation with normal marrowK L Simon Stoos National Heart, Lung, and Blood Institute, Bethesda, MD, USA Exp Hematol 27:162-8 The hemoglobin-deficit mutation is located on mouse chromosome 19M L Bloom National Institutes of Health, National Heart, Lung, and Blood Institute, Bldg. 10, Room 7C 118, Bethesda, Maryland 20892, USA Mamm Genome 9:666-7 | Scientific Experts
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Detail Information
Publications
Hemoglobin deficit: an inherited hypochromic anemia in the mouseR M Bannerman
Proc Soc Exp Biol Med 182:52-7
Proc Soc Exp Biol Med 182:52-7
The character and pathogenesis of hemoglobin deficit (gene symbol, hbd), an autosomal recessive trait in the mouse, were studied...
Loss of rapid transferrin receptor recycling due to a mutation in Sec15l1 in hbd miceMichael D Garrick
Department of Biochemistry, School of Medicine and Biomedical Sciences, SUNY, Buffalo, NY 14214, USA
Biochim Biophys Acta 1773:105-8
Department of Biochemistry, School of Medicine and Biomedical Sciences, SUNY, Buffalo, NY 14214, USA
Biochim Biophys Acta 1773:105-8
..It is due to a deletion that eliminates exon 8 of Sec15l1, the homolog of a gene that encodes an exocyst component in yeast...
The anemia of "haemoglobin-deficit" (hbd/hbd) mice is caused by a defect in transferrin cyclingAn Sheng Zhang
Department of Cellular and Developmental Biology, Oregon Health and Science University, Portland, Ore, USA
Exp Hematol 34:593-8
Department of Cellular and Developmental Biology, Oregon Health and Science University, Portland, Ore, USA
Exp Hematol 34:593-8
..The recently identified gene responsible, Sec15l1, is specific to hematopoietic stem cells and is homologous to a gene encoding a member of the exocyst pathway in ..
Iron metabolism mutant hbd mice have a deletion in Sec15l1, which has homology to a yeast gene for vesicle dockingRobert A White
Department of Medical Research, Children s Mercy Hospitals and Clinics, and Department of Pediatrics Genetics, University of Missouri at Kansas City School of Medicine, Kansas City, MO 64108, USA
Genomics 86:668-73
Department of Medical Research, Children s Mercy Hospitals and Clinics, and Department of Pediatrics Genetics, University of Missouri at Kansas City School of Medicine, Kansas City, MO 64108, USA
Genomics 86:668-73
..We have identified a strong candidate gene for hbd, Sec15l1, a homologue to yeast SEC15, which encodes a key protein in vesicle docking...
Iron metabolism in the hemoglobin-deficit mouse: correlation of diferric transferrin with hepcidin expressionSarah J Wilkins
Iron Metabolism Laboratory, The Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane, Queensland 4029, Australia
Blood 107:1659-64
Iron Metabolism Laboratory, The Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane, Queensland 4029, Australia
Blood 107:1659-64
..We have taken advantage of an inherited anemia of the mouse (hemoglobin deficit, or hbd) to gain insights into the factors regulating hepcidin expression...
A mutation in Sec15l1 causes anemia in hemoglobin deficit (hbd) miceJackie E Lim
Division of Hematology Oncology, Children s Hospital Boston, Karp Family Research Laboratories RM 8 125, Boston, Massachusetts 02115 5737, USA
Nat Genet 37:1270-3
Division of Hematology Oncology, Children s Hospital Boston, Karp Family Research Laboratories RM 8 125, Boston, Massachusetts 02115 5737, USA
Nat Genet 37:1270-3
..experiments, we show that the hbd mutation is an in-frame deletion of a conserved exon of the mouse gene Sec15l1, encoding one of two Sec15 proteins implicated in the mammalian exocyst complex...
B-cell deficiency and reduced B-cell reconstitution in hemoglobin-deficit miceKaren Lipovsky
Hematology Branch, National Heart, Lung, and Blood Institute NIH, Building 10 Room 7C118, 9000 Rockville Pike, Bethesda, MD 20892 1652, USA
Exp Hematol 31:1230-6
Hematology Branch, National Heart, Lung, and Blood Institute NIH, Building 10 Room 7C118, 9000 Rockville Pike, Bethesda, MD 20892 1652, USA
Exp Hematol 31:1230-6
OBJECTIVE: To study the effect of persistent hemoglobin-deficit mutation (hbd/hbd) on hematopoiesis and the function of hematopoietic stem cells (HSCs)...
Activation of Hex and mEg5 by retroviral insertion may contribute to mouse B-cell leukemiaG M Hansen
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
Oncogene 18:6531-9
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
Oncogene 18:6531-9
..In addition, this work highlights the use of genomic approaches for the study of position effect mutations...
The hemoglobin-deficit mouse: cure of the anemia following bone marrow transplantation with normal marrowK L Simon Stoos
National Heart, Lung, and Blood Institute, Bethesda, MD, USA
Exp Hematol 27:162-8
National Heart, Lung, and Blood Institute, Bethesda, MD, USA
Exp Hematol 27:162-8
The hemoglobin-deficit mouse mutant (hbd) is characterized by a severe microcytic anemia that is inherited in an autosomal-recessive manner...
The hemoglobin-deficit mutation is located on mouse chromosome 19M L Bloom
National Institutes of Health, National Heart, Lung, and Blood Institute, Bldg. 10, Room 7C 118, Bethesda, Maryland 20892, USA
Mamm Genome 9:666-7
National Institutes of Health, National Heart, Lung, and Blood Institute, Bldg. 10, Room 7C 118, Bethesda, Maryland 20892, USA
Mamm Genome 9:666-7
The hemoglobin-deficit mouse: analysis of phenotype and hematopoiesis in the transplant modelM L Bloom
National Heart, Lung, and Blood Institute, Bethesda, MD 20892, USA
Blood 90:2062-7
National Heart, Lung, and Blood Institute, Bethesda, MD 20892, USA
Blood 90:2062-7
The mouse mutant hemoglobin deficit (gene symbol hbd) is characterized by a severe microcytic anemia that is inherited in an autosomal-recessive manner...
[An additional house mouse mutant with anemia (hemoglobin deficiency)]H Scheufler
Z Versuchstierkd 11:348-53
Z Versuchstierkd 11:348-53
Hereditary disorders of the red cell in animalsR M Bannerman
Prog Hematol 8:131-79
Prog Hematol 8:131-79
Involvement of Exoc3l, a protein structurally related to the exocyst subunit Sec6, in insulin secretionTetsuya Saito
Division of Cellular and Molecular Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
Biomed Res 29:85-91
Division of Cellular and Molecular Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
Biomed Res 29:85-91
..Furthermore, overexpression of a deletion mutant of Exoc3l in MIN6 cells suppressed glucose-stimulated secretion. These results suggest that Exoc3l is involved in regulated exocytosis of insulin granules...