Gene Symbol: Exoc5
Description: exocyst complex component 5
Alias: AI447711, AI448003, Gm76, PRO1912, SEC10, Sec10l1, exocyst complex component 5, SEC10-like 1, exocyst complex component Sec10
Polgar N, Lee A, Lui V, Napoli J, Fogelgren B. The exocyst gene Sec10 regulates renal epithelial monolayer homeostasis and apoptotic sensitivity. Am J Physiol Cell Physiol. 2015;309:C190-201 pubmed publisher
..A previous study reported that shRNA knockdown of an exocyst central subunit, Sec10 (Sec10-KD) in Madin-Darby canine kidney (MDCK) cells disrupted primary cilia assembly and 3D cyst formation...
Saito T, Shibasaki T, Seino S. Involvement of Exoc3l, a protein structurally related to the exocyst subunit Sec6, in insulin secretion. Biomed Res. 2008;29:85-91 pubmed
..In co-immunoprecipitation experiments, Exoc3l was found to interact with Sec5, Sec8, and Sec10, all of which are binding partners of Sec6 in the exocyst complex...
Fogelgren B, Polgar N, Lui V, Lee A, Tamashiro K, Napoli J, et al
. Urothelial Defects from Targeted Inactivation of Exocyst Sec10 in Mice Cause Ureteropelvic Junction Obstructions. PLoS ONE. 2015;10:e0129346 pubmed publisher
..Here we report generation of a conditional knockout mouse for Sec10, a central component of the exocyst, which is the first conditional allele for any exocyst gene...
Seixas C, Choi S, Polgar N, Umberger N, East M, Zuo X, et al
. Arl13b and the exocyst interact synergistically in ciliogenesis. Mol Biol Cell. 2016;27:308-20 pubmed publisher
..In zebrafish, depletion of arl13b or the exocyst subunit sec10 causes phenotypes characteristic of defective cilia, such as curly tail up, edema, and abnormal pronephric kidney ..
Lee A, Polgar N, Napoli J, Lui V, Tamashiro K, Fujimoto B, et al
. Fibroproliferative response to urothelial failure obliterates the ureter lumen in a mouse model of prenatal congenital obstructive nephropathy. Sci Rep. 2016;6:31137 pubmed publisher
..We previously showed that conditional inactivation of Sec10, a central subunit of the exocyst complex, in the epithelial cells of the ureter and renal collecting system ..
Lobo G, Fulmer D, Guo L, Zuo X, Dang Y, Kim S, et al
. The exocyst is required for photoreceptor ciliogenesis and retinal development. J Biol Chem. 2017;292:14814-14826 pubmed publisher
..the function and mechanisms by which the exocyst regulates eye development in zebrafish, we focused on exoc5, a central component of the exocyst complex, by analyzing both exoc5 zebrafish mutants, and ..
Shin S, Vogt E, Jimenez Movilla M, Baibakov B, Dean J. Cytoplasmic cleavage of DPPA3 is required for intracellular trafficking and cleavage-stage development in mice. Nat Commun. 2017;8:1643 pubmed publisher
..Thus, the N-terminus of DPPA3 has a significant role in cytoplasmic vesicular trafficking in addition to its previously reported nuclear function. ..
Noh M, Jang H, Song D, Lee S, Lipschutz J, Park K, et al
. Downregulation of exocyst Sec10 accelerates kidney tubule cell recovery through enhanced cell migration. Biochem Biophys Res Commun. 2018;496:309-315 pubmed publisher
..We investigated the expression of a central exocyst complex member, Sec10, in kidneys following I/R injury, as well as the role of Sec10 in wound healing following scratch injury of ..