Gene Symbol: Exoc4
Description: exocyst complex component 4
Alias: C78892, Sec8, Sec8l1, exocyst complex component 4, SEC8-like 1, exocyst complex component Sec8
Species: mouse
Products:     Exoc4

Top Publications

  1. Friedrich G, Soriano P. Promoter traps in embryonic stem cells: a genetic screen to identify and mutate developmental genes in mice. Genes Dev. 1991;5:1513-23 pubmed
    ..Because no overt phenotype was detected in the remaining strains, these results suggest that a substantial proportion of mammalian genes identified by this approach are not essential for development. ..
  2. Peng X, Jia Z, Zhang Y, Ware J, Trimble W. The septin CDCrel-1 is dispensable for normal development and neurotransmitter release. Mol Cell Biol. 2002;22:378-87 pubmed
    ..Together, these data suggest that CDCrel-1 is not essential for neuronal development or function, and that changes in expression of other septins may account for its functional redundancy. ..
  3. Gerges N, Backos D, Rupasinghe C, Spaller M, Esteban J. Dual role of the exocyst in AMPA receptor targeting and insertion into the postsynaptic membrane. EMBO J. 2006;25:1623-34 pubmed
    ..We have found that two components of the exocyst complex, Sec8 and Exo70, separately control synaptic targeting and insertion of AMPA-type glutamate receptors...
  4. Chen X, Leto D, Xiong T, Yu G, Cheng A, DECKER S, et al. A Ral GAP complex links PI 3-kinase/Akt signaling to RalA activation in insulin action. Mol Biol Cell. 2011;22:141-52 pubmed publisher
    ..The RGC complex thus connects PI 3-kinase/Akt activity to the transport machineries responsible for GLUT4 translocation. ..
  5. Seixas C, Choi S, Polgar N, Umberger N, East M, Zuo X, et al. Arl13b and the exocyst interact synergistically in ciliogenesis. Mol Biol Cell. 2016;27:308-20 pubmed publisher
    ..Nevertheless, the precise role of Arl13b remains elusive. Here we report that the exocyst subunits Sec8, Exo70, and Sec5 bind preferentially to the GTP-bound form of Arl13b, consistent with the exocyst being an effector ..
  6. Friedrich G, Hildebrand J, Soriano P. The secretory protein Sec8 is required for paraxial mesoderm formation in the mouse. Dev Biol. 1997;192:364-74 pubmed
    The sec8 gene, isolated in a gene trap screen in embryonic stem cells, is required for paraxial mesoderm formation in the mouse...
  7. Thomas J, Lee Lin S, Green E. Human-mouse comparative mapping of the genomic region containing CDK6: localization of an evolutionary breakpoint. Mamm Genome. 1999;10:764-7 pubmed
  8. Sans N, Prybylowski K, Petralia R, Chang K, Wang Y, Racca C, et al. NMDA receptor trafficking through an interaction between PDZ proteins and the exocyst complex. Nat Cell Biol. 2003;5:520-30 pubmed
    ..Here, we find that synapse-associated protein 102 (SAP102) interacts with the PDZ-binding domain of Sec8, a member of the exocyst complex...
  9. Tsuboi T, Ravier M, Xie H, Ewart M, Gould G, Baldwin S, et al. Mammalian exocyst complex is required for the docking step of insulin vesicle exocytosis. J Biol Chem. 2005;280:25565-70 pubmed
    ..Here, we examined the role of the SEC6-SEC8 (exocyst) complex, implicated in trafficking of secretory vesicles to fusion sites in the plasma membrane in yeast ..

More Information


  1. Olsen O, Moore K, Fukata M, Kazuta T, Trinidad J, Kauer F, et al. Neurotransmitter release regulated by a MALS-liprin-alpha presynaptic complex. J Cell Biol. 2005;170:1127-34 pubmed
    ..These findings are consistent with a model whereby the MALS-CASK-liprin-alpha complex recruits components of the synaptic release machinery to adhesive proteins of the active zone. ..
  2. Lyons P, Peck G, Kettenbach A, Gerber S, Roudaia L, Lienhard G. Insulin stimulates the phosphorylation of the exocyst protein Sec8 in adipocytes. Biosci Rep. 2009;29:229-35 pubmed publisher
    ..b>Sec8 is a component of the exocyst complex that has been previously implicated in GLUT4 trafficking...
  3. Bolis A, Coviello S, Visigalli I, Taveggia C, Bachi A, Chishti A, et al. Dlg1, Sec8, and Mtmr2 regulate membrane homeostasis in Schwann cell myelination. J Neurosci. 2009;29:8858-70 pubmed publisher
    ..We here report that, in Schwann cells, Dlg1 also interacts with kinesin 13B (kif13B) and Sec8, which are involved in vesicle transport and membrane tethering in polarized cells, respectively...
  4. Ozcelik M, Cotter L, Jacob C, Pereira J, Relvas J, Suter U, et al. Pals1 is a major regulator of the epithelial-like polarization and the extension of the myelin sheath in peripheral nerves. J Neurosci. 2010;30:4120-31 pubmed publisher
    ..In addition, pals1 is required for the normal polarized localization of the vesicular markers sec8 and syntaxin4, and for the distribution of E-cadherin and myelin proteins PMP22 and MAG at the plasma membrane...
  5. Chernyshova Y, Leshchyns ka I, Hsu S, Schachner M, Sytnyk V. The neural cell adhesion molecule promotes FGFR-dependent phosphorylation and membrane targeting of the exocyst complex to induce exocytosis in growth cones. J Neurosci. 2011;31:3522-35 pubmed publisher
    ..NCAM promotes FGF receptor-mediated phosphorylation of two tyrosine residues in the sec8 subunit of the exocyst complex and is required for efficient recruitment of the exocyst complex to growth cones...
  6. Liu J, Qi Y, Li S, Hsu S, Saadat S, Hsu J, et al. CREG1 Interacts with Sec8 to Promote Cardiomyogenic Differentiation and Cell-Cell Adhesion. Stem Cells. 2016;34:2648-2660 pubmed publisher
    ..Furthermore, CREG1 directly interacts with Sec8 of the exocyst complex, which tethers vesicles to the plasma membrane...