Gene Symbol: Evi2a
Description: ecotropic viral integration site 2a
Alias: AW491894, Evi-2, Evi2, protein EVI2A, EVI-2A, ecotropic viral integration site 2A protein
Species: mouse
Products:     Evi2a

Top Publications

  1. Largaespada D, Shaughnessy J, Jenkins N, Copeland N. Retroviral integration at the Evi-2 locus in BXH-2 myeloid leukemia cell lines disrupts Nf1 expression without changes in steady-state Ras-GTP levels. J Virol. 1995;69:5095-102 pubmed
    ..These data suggest that neurofibromin is not the sole mediator of Ras-GAP activity in myeloid cells and may have a GAP-independent function in myeloid cells. ..
  2. Kurtz A, Zimmer A. The mouse homolog of the human Miller-Dieker chromosomal region (MDCR) maps to mouse chromosome 11 in close proximity to Mov9 and D11Nds1. Mamm Genome. 1995;6:145-6 pubmed
  3. Nehls M, Lüno K, Schorpp M, Krause S, Matysiak Scholze U, Prokop C, et al. A yeast artificial chromosome contig on mouse chromosome 11 encompassing the nu locus. Eur J Immunol. 1994;24:1721-3 pubmed
    ..5 centi Morgan on mouse chromosome 11. These results provide a suitable starting point to molecularly clone the nude gene. ..
  4. Swift S, Blackburn C, Morahan G, Ashworth A. Structure and chromosomal mapping of the TNF-alpha inducible endothelial protein 1 (Edp1) gene in the mouse. Biochim Biophys Acta. 1998;1442:394-8 pubmed
    ..However, surprisingly, the gene does not map to the expected region of mouse chromosome 11 suggesting that a change in the order of genes has occurred within a conserved linkage group. ..
  5. Hogan A, Heyner S, Charron M, Copeland N, Gilbert D, Jenkins N, et al. Glucose transporter gene expression in early mouse embryos. Development. 1991;113:363-72 pubmed
    ..Genetic mapping studies of glucose transporters in the mouse show that Glut-1 is located on chromosome 4, Glut-2 on chromosome 3, Glut-3 on chromosome 6, and Glut-4 on chromosome 11. ..
  6. Ohshima T, Kozak C, Nagle J, Pant H, Brady R, Kulkarni A. Molecular cloning and chromosomal mapping of the mouse gene encoding cyclin-dependent kinase 5 regulatory subunit p35. Genomics. 1996;35:372-5 pubmed
    ..The mouse Cdk5r transcript was detected only in the brain by Northern blot analysis. Mouse Cdk5r was mapped to a position on mouse chromosome 11. ..
  7. Buchberg A, Brownell E, Nagata S, Jenkins N, Copeland N. A comprehensive genetic map of murine chromosome 11 reveals extensive linkage conservation between mouse and human. Genetics. 1989;122:153-61 pubmed
  8. Huang M, Takac M, Kozak C, Jolicoeur P. The murine AIDS defective provirus acts as an insertional mutagen in its infected target B cells. J Virol. 1995;69:4069-78 pubmed
  9. Nakamura T, Largaespada D, Shaughnessy J, Jenkins N, Copeland N. Cooperative activation of Hoxa and Pbx1-related genes in murine myeloid leukaemias. Nat Genet. 1996;12:149-53 pubmed
    ..These studies provide the first genetic evidence that Pbx1-related genes cooperate with Hox genes in leukaemia formation and identify a number of new murine myeloid leukaemia genes. ..

More Information


  1. Jin D, Lyu M, Kozak C, Jeang K. Function of 14-3-3 proteins. Nature. 1996;382:308 pubmed
  2. Cho B, Shaughnessy J, Largaespada D, Bedigian H, Buchberg A, Jenkins N, et al. Frequent disruption of the Nf1 gene by a novel murine AIDS virus-related provirus in BXH-2 murine myeloid lymphomas. J Virol. 1995;69:7138-46 pubmed
    ..We present a model that accounts for the positive selection of MRV proviruses at Evi-2, which may allow selective identification of common viral integration sites harboring tumor suppressor genes. ..
  3. Elliott R, Lee B, Eicher E. Localization of the growth hormone gene to the distal half of mouse chromosome 11. Genomics. 1990;8:591-4 pubmed
    ..Segregation analysis also refined the location of Sparc (secreted acidic cysteine-rich glycoprotein) on mouse chromosome 11 to a position 16.7 +/- 4.2 map units proximal to Evi-2 (ecotropic viral integration site 2). ..
  4. Takahashi Y, Shimizu A, Sakai T, Endo Y, Osawa N, Shisa H, et al. Mapping of the nu gene using congenic nude strains and in situ hybridization. J Exp Med. 1992;175:873-6 pubmed
    ..From these data, we could estimate the location of the nu gene, not only genetically but also physically within a region that spans approximately 17 megabases (9 cM) between the Acrb and Mpo genes. ..
  5. Wilson S, Billings P, D EUSTACHIO P, Fournier R, Geissler E, Lalley P, et al. Clustering of cytokine genes on mouse chromosome 11. J Exp Med. 1990;171:1301-14 pubmed
  6. Buchberg A, Bedigian H, Taylor B, Brownell E, Ihle J, Nagata S, et al. Localization of Evi-2 to chromosome 11: linkage to other proto-oncogene and growth factor loci using interspecific backcross mice. Oncogene Res. 1988;2:149-65 pubmed
    ..This study revealed a number of interesting conserved linkage groups common to mouse and man. ..
  7. Bernier L, Colman D, D EUSTACHIO P. Chromosomal locations of genes encoding 2',3' cyclic nucleotide 3'-phosphodiesterase and glial fibrillary acidic protein in the mouse. J Neurosci Res. 1988;20:497-504 pubmed
    ..We have localized the GFAP gene to distal chromosome 11 in the mouse. There are two genetic loci identified by CNP probes, one is closely linked to the GFAP gene, and the other maps to chromosome 3. ..
  8. Cho Y, Chema D, Moskow J, Cho M, Schroeder W, Overbeek P, et al. Epidermal surface antigen (MS17S1) is highly conserved between mouse and human. Genomics. 1995;27:251-8 pubmed
    ..These data suggest that both the function and the regulation of ESA protein are of importance and that Esa (M17S1) is not the nude locus gene. ..
  9. Lane T, Deng C, Elson A, Lyu M, Kozak C, Leder P. Expression of Brca1 is associated with terminal differentiation of ectodermally and mesodermally derived tissues in mice. Genes Dev. 1995;9:2712-22 pubmed
    ..In addition, increased transcription of mammary Brca1 during pregnancy might contribute, in part, to the reduced cancer risk associated with exposure to pregnancy and lactation. ..
  10. Ivakine E, Fox C, Paterson A, Mortin Toth S, Canty A, Walton D, et al. Sex-specific effect of insulin-dependent diabetes 4 on regulation of diabetes pathogenesis in the nonobese diabetic mouse. J Immunol. 2005;174:7129-40 pubmed
    ..Additional studies will be required to address the question of whether a sex-specific effect of Idd4, observed in this study, is also present in the spontaneous model of the disease with striking female bias. ..
  11. Chen X, Kurre U, Jenkins N, Copeland N, Funk C. cDNA cloning, expression, mutagenesis of C-terminal isoleucine, genomic structure, and chromosomal localizations of murine 12-lipoxygenases. J Biol Chem. 1994;269:13979-87 pubmed
    ..Antibodies prepared against the two forms of 12-lipoxygenase revealed the differential distribution of the two enzymes throughout the mouse. ..
  12. Jenne D, Tinschert S, Dorschner M, Hameister H, Stephens K, Kehrer Sawatzki H. Complete physical map and gene content of the human NF1 tumor suppressor region in human and mouse. Genes Chromosomes Cancer. 2003;37:111-20 pubmed
    ..and cDNA structure of all functional genes, CYTOR4, FLJ12735, FLJ22729, CENTA2, MGC13061, NF1, OMG, EVI2B, EVI2A, KIAA1821, MGC11316, HCA66, KIAA0160, and WI-12393, from this region...
  13. Venturin M, Bentivegna A, Moroni R, Larizza L, Riva P. Evidence by expression analysis of candidate genes for congenital heart defects in the NF1 microdeletion interval. Ann Hum Genet. 2005;69:508-16 pubmed
  14. Nehls M, Lüno K, Schorpp M, Pfeifer D, Krause S, Matysiak Scholze U, et al. YAC/P1 contigs defining the location of 56 microsatellite markers and several genes across a 3.4-cM interval on mouse chromosome 11. Mamm Genome. 1995;6:321-31 pubmed
    ..In the cryb1/Nf1 interval of the central contig, several new genes have been identified by exon trapping and precisely localized with respect to known STS markers. ..
  15. Blackburn C, Griffith J, Morahan G. A high-resolution map of the chromosomal region surrounding the nude gene. Genomics. 1995;26:308-17 pubmed
    ..We also report the typing of the above microsatellite markers in the AKXD, AKXL, BXD, CXB, and BXH recombinant inbred strains, which confirmed the relative order and separation of loci in this region. ..
  16. Jenkins N, Rothe H, Gilbert D, Copeland N, Kolb H. Mapping of the gene for inducible nitric oxide (NO) synthase of mouse macrophages to chromosome 11, close to Evi-2, nu, and Idd-4. Genomics. 1994;19:402-4 pubmed
  17. Blatt C, Eversole Cire P, Cohn V, Zollman S, Fournier R, Mohandas L, et al. Chromosomal localization of genes encoding guanine nucleotide-binding protein subunits in mouse and human. Proc Natl Acad Sci U S A. 1988;85:7642-6 pubmed
    ..These mapping assignments will be useful in defining the extent of the G alpha gene family and may help in attempts to correlate specific genetic diseases with genes corresponding to G proteins. ..
  18. Buchberg A, Bedigian H, Jenkins N, Copeland N. Evi-2, a common integration site involved in murine myeloid leukemogenesis. Mol Cell Biol. 1990;10:4658-66 pubmed
    ..Interestingly, the human homolog of Evi-2 has recently been shown to be tightly linked to the von Recklinghausen neurofibromatosis locus, suggesting a role for Evi-2 in human disease as well. ..
  19. Malo D, Schurr E, Levenson R, Gros P. Assignment of Na,K-ATPase beta 2-subunit gene (Atpb-2) to mouse chromosome 11. Genomics. 1990;6:697-9 pubmed
  20. Kozak C, Danciger M, Bowes C, Adamson M, Palczewski K, Polans A, et al. Localization of three genes expressed in retina on mouse chromosome 11. Mamm Genome. 1995;6:142-4 pubmed
  21. Reiner O, Albrecht U, Gordon M, Chianese K, Wong C, Gal Gerber O, et al. Lissencephaly gene (LIS1) expression in the CNS suggests a role in neuronal migration. J Neurosci. 1995;15:3730-8 pubmed
    ..The direct correlation between cortical defects in MDS patients and Lis1 expression in the murine cortex suggest that the mouse is a model system suitable to study the mechanistic basis of this intriguing genetic disease. ..
  22. Byrd L. Regional localization of the nu mutation on mouse chromosome 11. Immunogenetics. 1993;37:157-9 pubmed
  23. Mock B, Krall M, Byrd L, Chin H, Barton C, Charles I, et al. The inducible form of nitric oxide synthase (NOS2) isolated from murine macrophages maps near the nude mutation on mouse chromosome 11. Eur J Immunogenet. 1994;21:231-8 pubmed
    ..The position of Nos2 was also mapped relative to the markers 115, Evi2, Cchlbl (previously unmapped), and Gfap...