Etv1

Summary

Gene Symbol: Etv1
Description: ets variant 1
Alias: ER81, Etsrp81, ETS translocation variant 1, ets variant gene 1, ets-related protein 81
Species: mouse
Products:     Etv1

Top Publications

  1. Flames N, Hobert O. Gene regulatory logic of dopamine neuron differentiation. Nature. 2009;458:885-9 pubmed publisher
    ..genes also contain phylogenetically conserved DA motifs that can be activated by the mouse ETS transcription factor Etv1 (also known as ER81), and a specific class of dopamine neurons fails to differentiate in mice lacking Etv1...
  2. Tuoc T, Stoykova A. Er81 is a downstream target of Pax6 in cortical progenitors. BMC Dev Biol. 2008;8:23 pubmed publisher
    ..Pax6 and the ETS family transcription factor Er81, which is presumed to play a role in the specification of a sublineage of layer 5 projection neurons, are expressed ..
  3. Inoue K, Ito K, Osato M, Lee B, Bae S, Ito Y. The transcription factor Runx3 represses the neurotrophin receptor TrkB during lineage commitment of dorsal root ganglion neurons. J Biol Chem. 2007;282:24175-84 pubmed
    ..Taken together, Runx3 determines TrkC positive sensory neuron identities through the transcriptional repression of TrkB when Trk-BTrkC double positive neurons differentiate into TrkC single positive neurons. ..
  4. Taniguchi H, He M, Wu P, Kim S, Paik R, Sugino K, et al. A resource of Cre driver lines for genetic targeting of GABAergic neurons in cerebral cortex. Neuron. 2011;71:995-1013 pubmed publisher
    ..As such, this approach will accelerate the study of GABAergic circuits throughout the mammalian brain. ..
  5. Zhu Y, Guthrie S. Expression of the ETS transcription factor ER81 in the developing chick and mouse hindbrain. Dev Dyn. 2002;225:365-8 pubmed
    b>ER81 is an ETS domain-containing transcription factor, which is expressed in various developing tissues and organs of the embryo and in pools of developing spinal motor neurons and proprioceptive sensory neurons...
  6. Levanon D, Bettoun D, Harris Cerruti C, Woolf E, Negreanu V, Eilam R, et al. The Runx3 transcription factor regulates development and survival of TrkC dorsal root ganglia neurons. EMBO J. 2002;21:3454-63 pubmed
    ..The data provide new genetic insights into the neurogenesis of DRGs and may help elucidate the molecular mechanisms underlying somatosensory-related ataxia in humans. ..
  7. Monte D, Coutte L, Baert J, Angeli I, Stehelin D, de Launoit Y. Molecular characterization of the ets-related human transcription factor ER81. Oncogene. 1995;11:771-9 pubmed
    ..is a homogeneous group of the ets transcription factor family and is composed of three known members, PEA3, ERM and ER81, which, on the amino acid (AA) level, are more than 95% identical within the DNA-binding domain (the Ets domain), ..
  8. Carney R, Cocas L, Hirata T, Mansfield K, Corbin J. Differential regulation of telencephalic pallial-subpallial boundary patterning by Pax6 and Gsh2. Cereb Cortex. 2009;19:745-59 pubmed publisher
    ..Thus, in addition to their well-characterized cross-repressive roles in dorsal/ventral patterning our analyses reveal important novel functions of Gsh2 and Pax6 in the regulation of PSB progenitor pool specification and patterning. ..
  9. Yoneshima H, Yamasaki S, Voelker C, Molnar Z, Christophe E, Audinat E, et al. Er81 is expressed in a subpopulation of layer 5 neurons in rodent and primate neocortices. Neuroscience. 2006;137:401-12 pubmed
    Laminar organization is a fundamental cytoarchitecture in mammalian CNS and a striking feature of the neocortex. ER81, a transcription factor, has recently been utilized as a marker of cells in the layer 5 of the neocortex...

More Information

Publications88

  1. Denaxa M, Kalaitzidou M, Garefalaki A, Achimastou A, Lasrado R, Maes T, et al. Maturation-promoting activity of SATB1 in MGE-derived cortical interneurons. Cell Rep. 2012;2:1351-62 pubmed publisher
  2. Fukuchi Shimogori T, Grove E. Emx2 patterns the neocortex by regulating FGF positional signaling. Nat Neurosci. 2003;6:825-31 pubmed
    ..These findings begin to clarify the signaling network that patterns the neocortical area map. ..
  3. Stenman J, Toresson H, Campbell K. Identification of two distinct progenitor populations in the lateral ganglionic eminence: implications for striatal and olfactory bulb neurogenesis. J Neurosci. 2003;23:167-74 pubmed
    ..This dorsal domain, however, contains cells that express the ETS transcription factor Er81, which is also expressed in granule and periglomerular cells of the developing and adult olfactory bulb...
  4. Brown T, McKnight S. Specificities of protein-protein and protein-DNA interaction of GABP alpha and two newly defined ets-related proteins. Genes Dev. 1992;6:2502-12 pubmed
    ..the selectivity and specificity of the GABP complex, we have isolated two new ETS family members, termed ER81 and ER71. ER81 and GABP alpha were present in most tissues of adult mice, whereas ER71 was restricted to testis...
  5. Ma Q, Fode C, Guillemot F, Anderson D. Neurogenin1 and neurogenin2 control two distinct waves of neurogenesis in developing dorsal root ganglia. Genes Dev. 1999;13:1717-28 pubmed
    ..These data reveal remarkable parallels in the roles of bHLH factors during neurogenesis in the DRG, and myogenesis in the neighboring myotome. ..
  6. Sugitani Y, Nakai S, Minowa O, Nishi M, Jishage K, Kawano H, et al. Brn-1 and Brn-2 share crucial roles in the production and positioning of mouse neocortical neurons. Genes Dev. 2002;16:1760-5 pubmed
    ..These data indicate that Brn-1 and Brn-2 share roles in the production and positioning of neocortical neuron development. ..
  7. Britanova O, de Juan Romero C, Cheung A, Kwan K, Schwark M, Gyorgy A, et al. Satb2 is a postmitotic determinant for upper-layer neuron specification in the neocortex. Neuron. 2008;57:378-92 pubmed publisher
    ..Satb2 therefore is required for the initiation of the UL1-specific genetic program and for the inactivation of DL- and UL2-specific genes. ..
  8. Flames N, Pla R, Gelman D, Rubenstein J, Puelles L, Marin O. Delineation of multiple subpallial progenitor domains by the combinatorial expression of transcriptional codes. J Neurosci. 2007;27:9682-95 pubmed
    ..Furthermore, the results of microtransplantation experiments in vivo corroborate that anatomically defined regions of the mouse subpallium, such as the medial ganglionic eminence, can be subdivided into functionally distinct domains. ..
  9. Langevin L, Mattar P, Scardigli R, Roussigne M, Logan C, Blader P, et al. Validating in utero electroporation for the rapid analysis of gene regulatory elements in the murine telencephalon. Dev Dyn. 2007;236:1273-86 pubmed
    ..this approach to test the telencephalic activities of a series of deletion constructs comprised of the zebrafish ER81 upstream regulatory region, allowing us to identify a previously uncharacterized enhancer that displays cross-..
  10. Yun K, Potter S, Rubenstein J. Gsh2 and Pax6 play complementary roles in dorsoventral patterning of the mammalian telencephalon. Development. 2001;128:193-205 pubmed
    ..The role of Pax6 in dorsalizing the telencephalon is similar to its role in the spinal cord, supporting the hypothesis that some dorsoventral patterning mechanisms are used at all axial levels of the central nervous system. ..
  11. Liodis P, Denaxa M, Grigoriou M, Akufo Addo C, Yanagawa Y, Pachnis V. Lhx6 activity is required for the normal migration and specification of cortical interneuron subtypes. J Neurosci. 2007;27:3078-89 pubmed
    ..We also show that Lhx6 activity is required for the normal tangential and radial migration of GABAergic interneurons in the cortex. ..
  12. Hanashima C, Li S, Shen L, Lai E, Fishell G. Foxg1 suppresses early cortical cell fate. Science. 2004;303:56-9 pubmed
    ..Hence, the competence to generate the earliest born neurons during later cortical development is actively suppressed but not lost. ..
  13. Schuurmans C, Armant O, Nieto M, Stenman J, Britz O, Klenin N, et al. Sequential phases of cortical specification involve Neurogenin-dependent and -independent pathways. EMBO J. 2004;23:2892-902 pubmed
    ..Our study thus reveals an unanticipated heterogeneity in the genetic mechanisms specifying the identity of neocortical projection neurons. ..
  14. Hasegawa H, Ashigaki S, Takamatsu M, Suzuki Migishima R, Ohbayashi N, Itoh N, et al. Laminar patterning in the developing neocortex by temporally coordinated fibroblast growth factor signaling. J Neurosci. 2004;24:8711-9 pubmed
  15. Arber S, Ladle D, Lin J, Frank E, Jessell T. ETS gene Er81 controls the formation of functional connections between group Ia sensory afferents and motor neurons. Cell. 2000;101:485-98 pubmed
    ..Two ETS transcription factors, ER81 and PEA3, are expressed by developing proprioceptive neurons and MNs, raising the possibility that these genes are ..
  16. Arber S, Han B, Mendelsohn M, Smith M, Jessell T, Sockanathan S. Requirement for the homeobox gene Hb9 in the consolidation of motor neuron identity. Neuron. 1999;23:659-74 pubmed
    ..These findings show that HB9 has an essential function in consolidating the identity of postmitotic MNs. ..
  17. Vrieseling E, Arber S. Target-induced transcriptional control of dendritic patterning and connectivity in motor neurons by the ETS gene Pea3. Cell. 2006;127:1439-52 pubmed
    ..These findings suggest that target-induced transcriptional programs control MN dendrite orientation and play a crucial role in the establishment of sensory-motor connections in the spinal cord. ..
  18. Saino Saito S, Cave J, Akiba Y, Sasaki H, Goto K, Kobayashi K, et al. ER81 and CaMKIV identify anatomically and phenotypically defined subsets of mouse olfactory bulb interneurons. J Comp Neurol. 2007;502:485-96 pubmed
    ..calcium/calmodulin-dependent protein kinase IV (CaMKIV) either alone or together with the Ets transcription factor ER81 was necessary for phenotypic determination during migration of progenitors...
  19. Hevner R, Shi L, Justice N, Hsueh Y, Sheng M, Smiga S, et al. Tbr1 regulates differentiation of the preplate and layer 6. Neuron. 2001;29:353-66 pubmed
    ..These results show that Tbr1 is a common genetic determinant for the differentiation of early-born glutamatergic neocortical neurons and provide insights into the functions of these neurons as regulators of cortical development. ..
  20. Patel T, Kramer I, Kucera J, Niederkofler V, Jessell T, Arber S, et al. Peripheral NT3 signaling is required for ETS protein expression and central patterning of proprioceptive sensory afferents. Neuron. 2003;38:403-16 pubmed
    ..This projection defect is similar to the defect in mice lacking the ETS transcription factor ER81. Few if any DRG neurons from Bax(-/-)/NT3(-/-) mice expressed ER81 protein...
  21. Hertel N, Redies C. Absence of layer-specific cadherin expression profiles in the neocortex of the reeler mutant mouse. Cereb Cortex. 2011;21:1105-17 pubmed publisher
    ..Our findings are compatible with a model, in which the ubiquitous dispersion of cadherin-expressing cells results from a dysgenesis of radial glial cells and a misrouting of migrating neuroblasts. ..
  22. Stenman J, Yu R, Evans R, Campbell K. Tlx and Pax6 co-operate genetically to establish the pallio-subpallial boundary in the embryonic mouse telencephalon. Development. 2003;130:1113-22 pubmed
    ..This correlates well with the malformation of the lateral and basolateral amygdala in Tlx mutants, both of which have been suggested to derive from ventral portions of the pallium. ..
  23. Alfonsi F, Filippi P, Salaün D, Delapeyrière O, Durbec P. LIFR beta plays a major role in neuronal identity determination and glial differentiation in the mouse facial nucleus. Dev Biol. 2008;313:267-78 pubmed
    ..We also show that LIFR beta is implicated in astrocyte and oligodendrocyte differentiation, specifically within the facial nucleus. ..
  24. Uemura M, Takeichi M. Alpha N-catenin deficiency causes defects in axon migration and nuclear organization in restricted regions of the mouse brain. Dev Dyn. 2006;235:2559-66 pubmed
    ..The ventricular structures were also deformed. These results indicate that alpha N-catenin has diverse roles in the organization of the central nervous system, but only in limited portions of the brain. ..
  25. Lickiss T, Cheung A, Hutchinson C, Taylor J, Molnar Z. Examining the relationship between early axon growth and transcription factor expression in the developing cerebral cortex. J Anat. 2012;220:201-11 pubmed publisher
  26. De Marco Garcia N, Jessell T. Early motor neuron pool identity and muscle nerve trajectory defined by postmitotic restrictions in Nkx6.1 activity. Neuron. 2008;57:217-31 pubmed publisher
    ..Our findings provide genetic evidence that neurons within motor pools possess an early transcriptional identity that controls target muscle specificity. ..
  27. Wu Y, Wang G, Scott S, Capecchi M. Hoxc10 and Hoxd10 regulate mouse columnar, divisional and motor pool identity of lumbar motoneurons. Development. 2008;135:171-82 pubmed
    ..Together, these results show that Hoxc10 and Hoxd10 play key roles in establishing lumbar motoneuron columnar, divisional and motor pool identity. ..
  28. Abe H, Okazawa M, Nakanishi S. The Etv1/Er81 transcription factor orchestrates activity-dependent gene regulation in the terminal maturation program of cerebellar granule cells. Proc Natl Acad Sci U S A. 2011;108:12497-502 pubmed publisher
    ..2)], and voltage-dependent Ca(2+) channels. This signaling then induces the Ets variant gene 1 (Etv1/Er81) transcription factor of the ETS family in an activity-dependent manner...
  29. Pan Y, Carbe C, Powers A, Feng G, Zhang X. Sprouty2-modulated Kras signaling rescues Shp2 deficiency during lens and lacrimal gland development. Development. 2010;137:1085-93 pubmed publisher
    ..We propose that the dynamic regulation of Sprouty by Shp2 might be important not only for modulating Ras signaling in lens and lacrimal gland development, but also for RTK signaling in general. ..
  30. Garg A, Bansal M, Gotoh N, Feng G, Zhong J, Wang F, et al. Alx4 relays sequential FGF signaling to induce lacrimal gland morphogenesis. PLoS Genet. 2017;13:e1007047 pubmed publisher
    ..Inactivation of ALX4/Alx4 causes lacrimal gland aplasia in both human and mouse. These results reveal a key role of Alx4 in mediating FGF-Shp2-FGF signaling in the neural crest for lacrimal gland development. ..
  31. Ishikawa T, Gotoh N, Murayama C, Abe T, Iwashita M, Matsuzaki F, et al. IgSF molecule MDGA1 is involved in radial migration and positioning of a subset of cortical upper-layer neurons. Dev Dyn. 2011;240:96-107 pubmed publisher
    ..These observations indicated that Mdga1 is involved in the migration and positioning of a subset of cortical neurons and suggested that the radial migration of upper-layer neurons might be differentially regulated. ..
  32. Abe H, Okazawa M, Nakanishi S. Gene regulation via excitation and BDNF is mediated by induction and phosphorylation of the Etv1 transcription factor in cerebellar granule cells. Proc Natl Acad Sci U S A. 2012;109:8734-9 pubmed publisher
    In maturing postnatal cerebellar granule cells, the Etv1/Er81 transcription factor is induced by sequential activity-dependent mechanisms through stimulation of AMPA and NMDA receptors, voltage-dependent Nav1...
  33. Nery S, Fishell G, Corbin J. The caudal ganglionic eminence is a source of distinct cortical and subcortical cell populations. Nat Neurosci. 2002;5:1279-87 pubmed
    ..Moreover, we report that the migratory fate of cells from the CGE is intrinsically determined by embryonic day 13.5 (E13.5). Together, these results provide the first insights into the development and fate of the CGE. ..
  34. Huang W, Chen Y, Page D. Hyperconnectivity of prefrontal cortex to amygdala projections in a mouse model of macrocephaly/autism syndrome. Nat Commun. 2016;7:13421 pubmed publisher
    ..These findings identify a mechanism of altered connectivity that has potential relevance to the pathophysiology of macrocephaly/autism syndrome and autism spectrum disorders featuring dysregulated mTOR signalling. ..
  35. Wei G, Badis G, Berger M, Kivioja T, Palin K, Enge M, et al. Genome-wide analysis of ETS-family DNA-binding in vitro and in vivo. EMBO J. 2010;29:2147-60 pubmed publisher
    ..that the ETS-binding profiles cluster into four distinct classes, and that all ETS factors linked to cancer, ERG, ETV1, ETV4 and FLI1, fall into just one of these classes...
  36. Huang T, Chuang H, Chou W, Chen C, Wang H, Chou S, et al. Tbr1 haploinsufficiency impairs amygdalar axonal projections and results in cognitive abnormality. Nat Neurosci. 2014;17:240-7 pubmed publisher
    ..Our study suggests that TBR1 is important in the regulation of amygdalar axonal connections and cognition. ..
  37. Dixit R, Wilkinson G, Cancino G, Shaker T, Adnani L, Li S, et al. Neurog1 and Neurog2 control two waves of neuronal differentiation in the piriform cortex. J Neurosci. 2014;34:539-53 pubmed publisher
    ..Neurog1 and Neurog2 thus have unique and redundant functions in the piriform cortex, controlling the timing of differentiation of early-born CR/lot cells and specifying the identities of later-born layer II/III neurons. ..
  38. Amaniti E, Kelman A, Mason J, Theil T. Cerebral Cortex Expression of Gli3 Is Required for Normal Development of the Lateral Olfactory Tract. PLoS ONE. 2015;10:e0141525 pubmed publisher
  39. Madakashira B, Kobrinski D, Hancher A, Arneman E, Wagner B, Wang F, et al. Frs2? enhances fibroblast growth factor-mediated survival and differentiation in lens development. Development. 2012;139:4601-12 pubmed publisher
    ..Therefore, tyrosine phosphorylation of Frs2? mediates Fgfr-dependent lens cell survival and provides a mechanistic basis for the unique fiber-differentiating capacity of Fgfs on mammalian lens epithelial cells. ..
  40. Kanatani S, Honda T, Aramaki M, Hayashi K, Kubo K, Ishida M, et al. The COUP-TFII/Neuropilin-2 is a molecular switch steering diencephalon-derived GABAergic neurons in the developing mouse brain. Proc Natl Acad Sci U S A. 2015;112:E4985-94 pubmed publisher
    ..Taken together, these results reveal that COUP-TFII/Nrp2 is a molecular switch determining the pathway and destination of migrating GABAergic neurons born in the POa. ..
  41. Betley J, Wright C, Kawaguchi Y, Erdelyi F, Szabo G, Jessell T, et al. Stringent specificity in the construction of a GABAergic presynaptic inhibitory circuit. Cell. 2009;139:161-74 pubmed publisher
    ..The organization of a GABAergic circuit that mediates presynaptic inhibition in the mammalian CNS is therefore controlled by a stringent program of sensory recognition and signaling. ..
  42. Hashimoto M, Ito R, Kitamura N, Namba K, Hisano Y. Epha4 controls the midline crossing and contralateral axonal projections of inferior olive neurons. J Comp Neurol. 2012;520:1702-20 pubmed publisher
    ..These observations indicate that EphA4 is involved in the contralateral axonal projections of IO neurons by preventing their cell bodies from crossing the midline FP. ..
  43. Kuerbitz J, Arnett M, Ehrman S, Williams M, Vorhees C, Fisher S, et al. Loss of Intercalated Cells (ITCs) in the Mouse Amygdala of Tshz1 Mutants Correlates with Fear, Depression, and Social Interaction Phenotypes. J Neurosci. 2018;38:1160-1177 pubmed publisher
  44. Eng S, Dykes I, Lanier J, Fedtsova N, Turner E. POU-domain factor Brn3a regulates both distinct and common programs of gene expression in the spinal and trigeminal sensory ganglia. Neural Dev. 2007;2:3 pubmed
  45. Chotteau Lelievre A, Dolle P, Peronne V, Coutte L, de Launoit Y, Desbiens X. Expression patterns of the Ets transcription factors from the PEA3 group during early stages of mouse development. Mech Dev. 2001;108:191-5 pubmed
    erm, er81 and pea3 are three related genes that define a novel Ets-related subfamily of transcription factors. The expression patterns of these genes has been previously characterized in the mouse from embryonic day (E) 9...
  46. Zarbalis K, Siegenthaler J, Choe Y, May S, Peterson A, Pleasure S. Cortical dysplasia and skull defects in mice with a Foxc1 allele reveal the role of meningeal differentiation in regulating cortical development. Proc Natl Acad Sci U S A. 2007;104:14002-7 pubmed
    ..Furthermore, we provide evidence that defects in meningeal differentiation can lead to severe cortical dysplasia. ..
  47. Chauvet S, Cohen S, Yoshida Y, Fekrane L, Livet J, Gayet O, et al. Gating of Sema3E/PlexinD1 signaling by neuropilin-1 switches axonal repulsion to attraction during brain development. Neuron. 2007;56:807-22 pubmed
    ..Our data therefore reveal a "gating" function of neuropilins in semaphorin-plexin signaling during the assembly of forebrain neuronal circuits. ..
  48. Suriben R, Kaihara K, Paolino M, Reichelt M, Kummerfeld S, Modrusan Z, et al. β-Cell Insulin Secretion Requires the Ubiquitin Ligase COP1. Cell. 2015;163:1457-67 pubmed publisher
    ..Here, we show that post-translational regulation of the transcription factors ETV1, ETV4, and ETV5 by the ubiquitin ligase COP1 (also called RFWD2) in β cells is critical for insulin secretion...
  49. Cohen S, Funkelstein L, Livet J, Rougon G, Henderson C, Castellani V, et al. A semaphorin code defines subpopulations of spinal motor neurons during mouse development. Eur J Neurosci. 2005;21:1767-76 pubmed
    ..These findings lead us to propose that semaphorins and their receptors might play important roles in the sorting of motor pools and the patterning of their afferent and efferent projections. ..
  50. Rodriguez M, Choi J, Park S, Sockanathan S. Gde2 regulates cortical neuronal identity by controlling the timing of cortical progenitor differentiation. Development. 2012;139:3870-9 pubmed
  51. Chou S, O Leary D. Role for Lhx2 in corticogenesis through regulation of progenitor differentiation. Mol Cell Neurosci. 2013;56:1-9 pubmed publisher
    ..We conclude that Lhx2 regulates the balance between proliferation and differentiation in cortical progenitors and through this mechanism Lhx2 controls cortical size. ..
  52. Fuccillo M, Rutlin M, Fishell G. Removal of Pax6 partially rescues the loss of ventral structures in Shh null mice. Cereb Cortex. 2006;16 Suppl 1:i96-102 pubmed
    ..Interestingly, we observe that while the expression of ER81 in the ventral telencephalon is expanded, the expression of Ebf1 is lost...
  53. Yan Y, Wladyka C, Fujii J, Sockanathan S. Prdx4 is a compartment-specific H2O2 sensor that regulates neurogenesis by controlling surface expression of GDE2. Nat Commun. 2015;6:7006 pubmed publisher
    ..Thus, Prdx4 oxidative activity acts as a sensor to directly couple neuronal differentiation with redox environments in the ER. ..
  54. Netzer S, Leenders F, Dumont P, Baert J, De Launoit Y. Ectopic expression of the ets transcription factor ER81 in transgenic mouse mammary gland enhances both urokinase plasminogen activator and stromelysin-1 transcription. Transgenic Res. 2002;11:123-31 pubmed
    The PEA3 group members PEA3, ER81 and ERM, which are highly conserved transcription factors from the Ets family, are over-expressed in metastatic mammary tumors...
  55. Nomura T, Takahashi M, Hara Y, Osumi N. Patterns of neurogenesis and amplitude of Reelin expression are essential for making a mammalian-type cortex. PLoS ONE. 2008;3:e1454 pubmed publisher
    ..These lines of evidence shed light on the developmental programs underlying the evolution of the mammalian specific laminated cortex...
  56. Okada T, Okumura Y, Motoyama J, Ogawa M. FGF8 signaling patterns the telencephalic midline by regulating putative key factors of midline development. Dev Biol. 2008;320:92-101 pubmed publisher
  57. Kwan K, Lam M, Krsnik Z, Kawasawa Y, Lefebvre V, Sestan N. SOX5 postmitotically regulates migration, postmigratory differentiation, and projections of subplate and deep-layer neocortical neurons. Proc Natl Acad Sci U S A. 2008;105:16021-6 pubmed publisher
    ..Thus, SOX5 postmitotically regulates the migration, postmigratory differentiation, and subcortical projections of subplate and deep-layer neurons. ..
  58. Ran L, Murphy D, Sher J, Cao Z, Wang S, Walczak E, et al. ETV1-Positive Cells Give Rise to BRAFV600E -Mutant Gastrointestinal Stromal Tumors. Cancer Res. 2017;77:3758-3765 pubmed publisher
    ..b>ETV1 is a master regulator in the intestinal cells of Cajal (ICC), thought to be the cells of origin of GIST...
  59. Chotteau Lelievre A, Montesano R, Soriano J, Soulie P, Desbiens X, De Launoit Y. PEA3 transcription factors are expressed in tissues undergoing branching morphogenesis and promote formation of duct-like structures by mammary epithelial cells in vitro. Dev Biol. 2003;259:241-57 pubmed
    ..Erm, Er81 and Pea3 are three highly related transcription factors belonging to the Ets family, within which they form the ..
  60. Simón Carrasco L, Grana O, Salmón M, Jacob H, Gutierrez A, Jiménez G, et al. Inactivation of Capicua in adult mice causes T-cell lymphoblastic lymphoma. Genes Dev. 2017;31:1456-1468 pubmed publisher
    ..These observations illustrate that CIC inactivation plays a key role in this human malignancy. ..
  61. Hayashi Y, Bardsley M, Toyomasu Y, Milosavljevic S, Gajdos G, Choi K, et al. Platelet-Derived Growth Factor Receptor-α Regulates Proliferation of Gastrointestinal Stromal Tumor Cells With Mutations in KIT by Stabilizing ETV1. Gastroenterology. 2015;149:420-32.e16 pubmed publisher
    ..could reduce proliferation of GIST cells with mutant KIT via effects on the KIT-dependent transcription factor ETV1. We studied 53 gastric, small intestinal, rectal, or abdominal GISTs collected immediately after surgery or ..
  62. Sussel L, Marin O, Kimura S, Rubenstein J. Loss of Nkx2.1 homeobox gene function results in a ventral to dorsal molecular respecification within the basal telencephalon: evidence for a transformation of the pallidum into the striatum. Development. 1999;126:3359-70 pubmed
    ..We present evidence that these phenotypes result from a ventral-to-dorsal transformation of the pallidal primordium into a striatal-like anlage. ..
  63. Tervonen T, Louhivuori V, Sun X, Hokkanen M, Kratochwil C, Zebryk P, et al. Aberrant differentiation of glutamatergic cells in neocortex of mouse model for fragile X syndrome. Neurobiol Dis. 2009;33:250-9 pubmed publisher
    ..These abnormalities were associated with an increased density of pyramidal cells of the layer V in the early postnatal neocortex suggesting a role for FMRP in the regulation of the differentiation of neocortical glutamatergic neurons. ..
  64. David A, Tiveron M, Defays A, Beclin C, Camosseto V, Gatti E, et al. BAD-LAMP defines a subset of early endocytic organelles in subpopulations of cortical projection neurons. J Cell Sci. 2007;120:353-65 pubmed
    ..The striking correlation between the appearance of BAD-LAMP and cortical synatogenesis points towards a physiological role of this vesicular determinant for neuronal function. ..
  65. Miquelajáuregui A, Varela Echavarría A, Ceci M, García Moreno F, Ricaño I, Hoang K, et al. LIM-homeobox gene Lhx5 is required for normal development of Cajal-Retzius cells. J Neurosci. 2010;30:10551-62 pubmed publisher
    ..These results reveal a complex role for Lhx5 in regulating the development and normal distribution of C-R cells in the developing forebrain. ..
  66. Hack I, Hellwig S, Junghans D, Brunne B, Bock H, Zhao S, et al. Divergent roles of ApoER2 and Vldlr in the migration of cortical neurons. Development. 2007;134:3883-91 pubmed
    ..We present evidence for divergent roles of the two reelin receptors Vldlr and ApoER2, with Vldlr mediating a stop signal for migrating neurons and ApoER2 being essential for the migration of late generated neocortical neurons. ..
  67. Caubit X, Tiveron M, Cremer H, Fasano L. Expression patterns of the three Teashirt-related genes define specific boundaries in the developing and postnatal mouse forebrain. J Comp Neurol. 2005;486:76-88 pubmed
    ..Comparison of the mTsh1 expression domain with the domains of Er81 and Islet1, which mark two distinct progenitor populations in the subventricular zone of the LGE, suggests that ..
  68. Shen Q, Wang Y, Dimos J, Fasano C, Phoenix T, Lemischka I, et al. The timing of cortical neurogenesis is encoded within lineages of individual progenitor cells. Nat Neurosci. 2006;9:743-51 pubmed
    ..Our data demonstrate that neural stem cells change neuropotency during development and have a window of plasticity when restrictions can be reversed. ..
  69. Xiang C, Baubet V, Pal S, Holderbaum L, Tatard V, Jiang P, et al. RP58/ZNF238 directly modulates proneurogenic gene levels and is required for neuronal differentiation and brain expansion. Cell Death Differ. 2012;19:692-702 pubmed publisher
    ..Thus, RP58 may act to favor neuronal differentiation and brain growth by coherently repressing multiple proneurogenic genes in a timely manner. ..
  70. Dehorter N, Ciceri G, Bartolini G, Lim L, del Pino I, Marín O. Tuning of fast-spiking interneuron properties by an activity-dependent transcriptional switch. Science. 2015;349:1216-20 pubmed publisher
    ..properties of fast-spiking (FS) interneurons through the postmitotic expression of the transcriptional regulator Er81. In the adult cortex, Er81 protein levels define a spectrum of FS basket cells with different properties, whose ..
  71. Long J, Garel S, Alvarez Dolado M, Yoshikawa K, Osumi N, Alvarez Buylla A, et al. Dlx-dependent and -independent regulation of olfactory bulb interneuron differentiation. J Neurosci. 2007;27:3230-43 pubmed
  72. Wang G, Scott S. Onset of ETS expression is not accelerated by premature exposure to signals from limb mesenchyme. Dev Dyn. 2007;236:2109-17 pubmed
    The ETS transcription factors ER81 and PEA3 are expressed in discrete populations of sensory and motor neurons and regulate late events in neuronal development and limb innervation...
  73. Kuwako K, Kakumoto K, Imai T, Igarashi M, Hamakubo T, Sakakibara S, et al. Neural RNA-binding protein Musashi1 controls midline crossing of precerebellar neurons through posttranscriptional regulation of Robo3/Rig-1 expression. Neuron. 2010;67:407-21 pubmed publisher
    ..Together, these findings indicate that Msi1-mediated posttranscriptional regulation of Robo3 controls midline crossing of precerebellar neurons...
  74. Smidt M, Burbach J. A passport to neurotransmitter identity. Genome Biol. 2009;10:229 pubmed publisher
    ..Comparison of a regulatory network that specifies dopaminergic neurons in Caenorhabditis elegans to the development of vertebrate dopamine systems in the mouse reveals a possible partial conservation of such a network. ..
  75. Firlej V, Bocquet B, Desbiens X, De Launoit Y, Chotteau Lelievre A. Pea3 transcription factor cooperates with USF-1 in regulation of the murine bax transcription without binding to an Ets-binding site. J Biol Chem. 2005;280:887-98 pubmed
    ..Taken together, our results suggest that Pea3 may regulate bax transcription via the interaction with USF-1 but without binding to DNA. ..
  76. Kurpios N, Sabolic N, Shepherd T, Fidalgo G, Hassell J. Function of PEA3 Ets transcription factors in mammary gland development and oncogenesis. J Mammary Gland Biol Neoplasia. 2003;8:177-90 pubmed
    ..Notably, pea3, as well as its close paralogs er81 and erm, which comprise the pea3 subfamily of ets genes, are coordinately overexpressed in mouse mammary tumors...
  77. Ran L, Sirota I, Cao Z, Murphy D, Chen Y, Shukla S, et al. Combined inhibition of MAP kinase and KIT signaling synergistically destabilizes ETV1 and suppresses GIST tumor growth. Cancer Discov. 2015;5:304-15 pubmed publisher
    ..The ETS family transcription factor ETV1 is a master regulator of the ICC lineage...
  78. Patel N, Sharpe P, Miletich I. Coordination of epithelial branching and salivary gland lumen formation by Wnt and FGF signals. Dev Biol. 2011;358:156-67 pubmed publisher
    ..Altogether, these findings point to a key function of FGF signaling in the maintenance of an undifferentiated state in endbud cells by inhibition of a ductal fate...
  79. Chotteau Lelievre A, Desbiens X, Pelczar H, Defossez P, de Launoit Y. Differential expression patterns of the PEA3 group transcription factors through murine embryonic development. Oncogene. 1997;15:937-52 pubmed
    ERM, ER81 and PEA3 are three highly related transcription factors belonging to the ETS family. Together they form the PEA3 group within this family...