Gene Symbol: esk
Description: Ttk protein kinase
Alias: AL022661, Esk1, Mps1, PYT, esk, dual specificity protein kinase TTK
Foijer F, Xie S, Simon J, Bakker P, Conte N, Davis S, et al
. Chromosome instability induced by Mps1 and p53 mutation generates aggressive lymphomas exhibiting aneuploidy-induced stress. Proc Natl Acad Sci U S A. 2014;111:13427-32 pubmed publisher
..A flanked by Lox mutation was introduced into the monopolar spindle 1 (Mps1) spindle-assembly checkpoint gene so that Cre-mediated recombination would create a truncated protein (Mps1(DK)) ..
Isokane M, Walter T, Mahen R, Nijmeijer B, HÃ©richÃ© J, Miura K, et al
. ARHGEF17 is an essential spindle assembly checkpoint factor that targets Mps1 to kinetochores. J Cell Biol. 2016;212:647-59 pubmed publisher
..for SAC activity, because it is the major targeting factor that controls localization of the checkpoint kinase Mps1 to the kinetochore...
Douville E, Afar D, Howell B, Letwin K, Tannock L, Ben David Y, et al
. Multiple cDNAs encoding the esk kinase predict transmembrane and intracellular enzyme isoforms. Mol Cell Biol. 1992;12:2681-9 pubmed
A novel protein kinase, the Esk kinase, has been isolated from an embryonal carcinoma (EC) cell line by using an expression cloning strategy. Sequence analysis of two independent cDNA clones (2.97 and 2...
DANIEL J, Coulter J, Woo J, Wilsbach K, Gabrielson E. High levels of the Mps1 checkpoint protein are protective of aneuploidy in breast cancer cells. Proc Natl Acad Sci U S A. 2011;108:5384-9 pubmed publisher
..Noting that aneuploidy in human breast cancer correlates with increased expression levels of the Mps1 checkpoint gene, we investigated whether these high levels of Mps1 contribute to the ability of breast cancer cells ..
Hached K, Xie S, Buffin E, Cladière D, Rachez C, Sacras M, et al
. Mps1 at kinetochores is essential for female mouse meiosis I. Development. 2011;138:2261-71 pubmed publisher
..occupancy for silencing the SAC and the importance of certain essential SAC components, such as the kinase Mps1, are unknown in mammalian oocytes...
Ekdahl Y, Farahani H, Behm M, Lagergren J, Ohman M. A-to-I editing of microRNAs in the mammalian brain increases during development. Genome Res. 2012;22:1477-87 pubmed publisher
..Taken together, our results imply that RNA editing influences the miRNA repertoire during brain maturation. ..
Touati S, Buffin E, CladiÃ¨re D, Hached K, Rachez C, van Deursen J, et al
. Mouse oocytes depend on BubR1 for proper chromosome segregation but not for prophase I arrest. Nat Commun. 2015;6:6946 pubmed publisher
Diril M, Bisteau X, Kitagawa M, Caldez M, Wee S, Gunaratne J, et al
. Loss of the Greatwall Kinase Weakens the Spindle Assembly Checkpoint. PLoS Genet. 2016;12:e1006310 pubmed publisher
..MEFs display reduced phosphorylation of a number of proteins in mitosis, which include the essential SAC kinase MPS1. We further demonstrate that Mastl is required for multi-site phosphorylation of MPS1 as well as robust MPS1 kinase ..