Gene Symbol: Erp44
Description: endoplasmic reticulum protein 44
Alias: 1110001E24Rik, AI849526, AL033348, Txndc4, endoplasmic reticulum resident protein 44, ER protein 44, endoplasmic reticulum resident protein 44kDa, endoplasmic reticulum resident protein ERp44, thioredoxin domain containing 4 (endoplasmic reticulum), thioredoxin domain-containing protein 4
Species: mouse
Products:     Erp44

Top Publications

  1. Anelli T, Alessio M, Mezghrani A, Simmen T, Talamo F, Bachi A, et al. ERp44, a novel endoplasmic reticulum folding assistant of the thioredoxin family. EMBO J. 2002;21:835-44 pubmed
    ..Here, we characterize a novel ER resident protein (ERp44), which contains a thioredoxin domain with a CRFS motif and is induced during ER stress...
  2. Higo T, Hattori M, Nakamura T, Natsume T, Michikawa T, Mikoshiba K. Subtype-specific and ER lumenal environment-dependent regulation of inositol 1,4,5-trisphosphate receptor type 1 by ERp44. Cell. 2005;120:85-98 pubmed
    ..In this study, we found that ERp44, an ER lumenal protein of the thioredoxin family, directly interacts with the third lumenal loop of IP(3)R type 1 (..
  3. Turano C, Coppari S, Altieri F, Ferraro A. Proteins of the PDI family: unpredicted non-ER locations and functions. J Cell Physiol. 2002;193:154-63 pubmed
  4. Wang Z, Schraw T, Kim J, Khan T, Rajala M, Follenzi A, et al. Secretion of the adipocyte-specific secretory protein adiponectin critically depends on thiol-mediated protein retention. Mol Cell Biol. 2007;27:3716-31 pubmed
    ..Adiponectin is covalently bound to the ER chaperone ERp44. An adiponectin mutant lacking cysteine 39 fails to stably interact with ERp44, demonstrating that this residue is ..
  5. Holbrook L, Watkins N, Simmonds A, Jones C, Ouwehand W, Gibbins J. Platelets release novel thiol isomerase enzymes which are recruited to the cell surface following activation. Br J Haematol. 2010;148:627-37 pubmed publisher
    ..of five additional thiol isomerases in human and mouse platelets and megakaryocytes, namely; ERp57, ERp72, ERp44, ERp29 and TMX3...
  6. Wang D, Abbasi C, El Rass S, Li J, Dawood F, Naito K, et al. Endoplasmic reticulum resident protein 44 (ERp44) deficiency in mice and zebrafish leads to cardiac developmental and functional defects. J Am Heart Assoc. 2014;3:e001018 pubmed publisher
    Endoplasmic reticulum (ER) resident protein 44 (ERp44) is a member of the protein disulfide isomerase family, is induced during ER stress, and may be involved in regulating Ca(2+) homeostasis...
  7. Hisatsune C, Ebisui E, Usui M, Ogawa N, Suzuki A, Mataga N, et al. ERp44 Exerts Redox-Dependent Control of Blood Pressure at the ER. Mol Cell. 2015;58:1015-27 pubmed publisher
    ..Here, we show that angiotensin II is regulated by ERp44, a factor involved in disulfide bond formation in the ER...
  8. Hampe L, Radjainia M, Xu C, Harris P, Bashiri G, Goldstone D, et al. Regulation and Quality Control of Adiponectin Assembly by Endoplasmic Reticulum Chaperone ERp44. J Biol Chem. 2015;290:18111-23 pubmed publisher
    ..The endoplasmic reticulum (ER) chaperone ERp44 retains adiponectin in the early secretory compartment and tightly controls the oxidative state of Cys(39) and the ..
  9. Hedlund E, Karsten S, Kudo L, Geschwind D, Carpenter E. Identification of a Hoxd10-regulated transcriptional network and combinatorial interactions with Hoxa10 during spinal cord development. J Neurosci Res. 2004;75:307-19 pubmed

More Information


  1. Wei Z, Seldin M, Natarajan N, Djemal D, Peterson J, Wong G. C1q/tumor necrosis factor-related protein 11 (CTRP11), a novel adipose stroma-derived regulator of adipogenesis. J Biol Chem. 2013;288:10214-29 pubmed publisher
    ..These results implicate CTRP11 as a novel secreted regulator of adipogenesis and highlight the potential paracrine cross-talk between adipocytes and cells of the stromal vascular compartment in maintaining adipose tissue homeostasis. ..