Gene Symbol: Ero1lb
Description: ERO1-like beta (S. cerevisiae)
Alias: 1300013B24Rik, 1700065B09Rik, AI447560, Ero1b, ero1-beta, ERO1-like protein beta, ERO1-L-beta, endoplasmic oxidoreductase 1 beta, endoplasmic oxidoreductin-1-like protein B, endoplasmic reticulum oxidoreductase beta, endoplasmic reticulum oxidoreductin-1-like protein B, oxidoreductin-1-L-beta
Appenzeller Herzog C, Riemer J, Zito E, Chin K, Ron D, Spiess M, et al
. Disulphide production by Ero1?-PDI relay is rapid and effectively regulated. EMBO J. 2010;29:3318-29 pubmed publisher
..Instead, our data suggest that a dynamic equilibrium between Ero1- and glutathione disulphide-mediated oxidation of PDIs constitutes an important element of ER redox homeostasis. ..
Zito E, Hansen H, Yeo G, Fujii J, Ron D. Endoplasmic reticulum thiol oxidase deficiency leads to ascorbic acid depletion and noncanonical scurvy in mice. Mol Cell. 2012;48:39-51 pubmed publisher
..Compromised ER disulfide relay thus exposes protein thiols to competing oxidation to sulfenic acid, resulting in depletion of ascorbic acid, impaired procollagen proline 4-hydroxylation, and a noncanonical form of scurvy. ..
Zito E, Chin K, Blais J, Harding H, Ron D. ERO1-beta, a pancreas-specific disulfide oxidase, promotes insulin biogenesis and glucose homeostasis. J Cell Biol. 2010;188:821-32 pubmed publisher
..We report in this study that homozygosity for a disrupting allele of Ero1lb selectively compromises oxidative folding of proinsulin and promotes glucose intolerance in mutant mice...
Zito E, Melo E, Yang Y, Wahlander Ã, Neubert T, Ron D. Oxidative protein folding by an endoplasmic reticulum-localized peroxiredoxin. Mol Cell. 2010;40:787-97 pubmed publisher
..These observations implicate ER-localized PRDX4 in a previously unanticipated, parallel, ERO1-independent pathway that couples hydroperoxide production to oxidative protein folding in mammalian cells. ..
Posey K, Coustry F, Veerisetty A, Liu P, Alcorn J, Hecht J. Chop (Ddit3) is essential for D469del-COMP retention and cell death in chondrocytes in an inducible transgenic mouse model of pseudoachondroplasia. Am J Pathol. 2012;180:727-37 pubmed publisher
..Taken together, these results suggest that there may be an optimal window before the induction of significant D469del-COMP retention during which endoplasmic reticulum stress could be targeted. ..
Awazawa M, Futami T, Sakada M, Kaneko K, Ohsugi M, Nakaya K, et al
. Deregulation of pancreas-specific oxidoreductin ERO1? in the pathogenesis of diabetes mellitus. Mol Cell Biol. 2014;34:1290-9 pubmed publisher
..These data indicate the importance of the fine-tuning of the ER redox state, the disturbance of which would compromise the function of ? cells in insulin synthesis and thus contribute to the pathogenesis of diabetes mellitus. ..
Aksu S, Koczan D, Renne U, Thiesen H, Brockmann G. Differentially expressed genes in adipose tissues of high body weight-selected (obese) and unselected (lean) mouse lines. J Appl Genet. 2007;48:133-43 pubmed
..14 out of these genes, occur in QTL regions for body weight or abdominal fat weight. Further analyses are necessary to discriminate between genes directly causing QTL effects and indirectly regulated differentially expressed genes. ..
Khoo C, Yang J, Rajpal G, Wang Y, Liu J, Arvan P, et al
. Endoplasmic reticulum oxidoreductin-1-like β (ERO1lβ) regulates susceptibility to endoplasmic reticulum stress and is induced by insulin flux in β-cells. Endocrinology. 2011;152:2599-608 pubmed publisher
..These findings demonstrate roles for the PDX1 target ERO1lβ in maintaining insulin content and regulating cell survival during ER stress. ..
Avezov E, Cross B, Kaminski Schierle G, Winters M, Harding H, Melo E, et al
. Lifetime imaging of a fluorescent protein sensor reveals surprising stability of ER thiol redox. J Cell Biol. 2013;201:337-49 pubmed publisher
..These findings recommend fluorescent lifetime imaging as a sensitive method to track ER redox homeostasis in mammalian cells. ..