Gene Symbol: Erg
Description: ETS transcription factor
Alias: D030036I24Rik, transcriptional regulator ERG, avian erythroblastosis virus E-26 (v-ets) oncogene related
Species: mouse
Products:     Erg

Top Publications

  1. Taoudi S, Bee T, Hilton A, Knezevic K, Scott J, Willson T, et al. ERG dependence distinguishes developmental control of hematopoietic stem cell maintenance from hematopoietic specification. Genes Dev. 2011;25:251-62 pubmed publisher
    ..commitment, particular interest has focused on the role of the ETS family of transcription factors; of these, ERG is predicted to play an important role in the initiation of hematopoiesis, yet we do not know if or when ERG is ..
  2. Rivera R, Stuiver M, Steenbergen R, Murre C. Ets proteins: new factors that regulate immunoglobulin heavy-chain gene expression. Mol Cell Biol. 1993;13:7163-9 pubmed
    We used a DNA-protein interaction screening method to isolate a cDNA, Erg-3, whose product binds to a site, designated pi, present in the immunoglobulin (Ig) heavy-chain gene enhancer...
  3. Vijayaraj P, Le Bras A, Mitchell N, Kondo M, Juliao S, Wasserman M, et al. Erg is a crucial regulator of endocardial-mesenchymal transformation during cardiac valve morphogenesis. Development. 2012;139:3973-85 pubmed publisher
    During murine embryogenesis, the Ets factor Erg is highly expressed in endothelial cells of the developing vasculature and in articular chondrocytes of developing bone. We identified seven isoforms for the mouse Erg gene...
  4. Vlaeminck Guillem V, Carrere S, Dewitte F, Stehelin D, Desbiens X, Duterque Coquillaud M. The Ets family member Erg gene is expressed in mesodermal tissues and neural crests at fundamental steps during mouse embryogenesis. Mech Dev. 2000;91:331-5 pubmed
    The Erg gene belongs to the Ets family encoding a class of transcription factors...
  5. Zong Y, Xin L, Goldstein A, Lawson D, Teitell M, Witte O. ETS family transcription factors collaborate with alternative signaling pathways to induce carcinoma from adult murine prostate cells. Proc Natl Acad Sci U S A. 2009;106:12465-70 pubmed publisher
    ..However, combined expression of ERG with additional genetic alternations associated with human prostate cancer can lead to aggressive disease...
  6. Pimanda J, Chan W, Donaldson I, Bowen M, Green A, Gottgens B. Endoglin expression in the endothelium is regulated by Fli-1, Erg, and Elf-1 acting on the promoter and a -8-kb enhancer. Blood. 2006;107:4737-45 pubmed
    ..8 enhancer and the promoter depend on conserved Ets sites, which were bound in endothelial cells in vivo by Fli-1, Erg, and Elf-1...
  7. Kruse E, Loughran S, Baldwin T, Josefsson E, Ellis S, Watson D, et al. Dual requirement for the ETS transcription factors Fli-1 and Erg in hematopoietic stem cells and the megakaryocyte lineage. Proc Natl Acad Sci U S A. 2009;106:13814-9 pubmed publisher
    Fli-1 and Erg are closely related members of the Ets family of transcription factors. Both genes are translocated in human cancers, including Ewing's sarcoma, leukemia, and in the case of Erg, more than half of all prostate cancers...
  8. Nikolova Krstevski V, Yuan L, Le Bras A, Vijayaraj P, Kondo M, Gebauer I, et al. ERG is required for the differentiation of embryonic stem cells along the endothelial lineage. BMC Dev Biol. 2009;9:72 pubmed publisher
    ..Ets related gene (ERG) has recently been shown to participate in the transcriptional regulation of a number of endothelial specific genes ..
  9. Loughran S, Kruse E, Hacking D, de Graaf C, Hyland C, Willson T, et al. The transcription factor Erg is essential for definitive hematopoiesis and the function of adult hematopoietic stem cells. Nat Immunol. 2008;9:810-9 pubmed publisher
    Ets-related gene (ERG), which encodes a member of the Ets family of transcription factors, is a potent oncogene...

More Information


  1. Iwamoto M, Tamamura Y, Koyama E, Komori T, Takeshita N, Williams J, et al. Transcription factor ERG and joint and articular cartilage formation during mouse limb and spine skeletogenesis. Dev Biol. 2007;305:40-51 pubmed
    ..In previous studies we found that the ets transcription factor ERG and its alternatively-spliced variant C-1-1 have roles in joint formation in chick...
  2. Smith A, Calero Nieto F, Schütte J, Kinston S, Timms R, Wilson N, et al. Integration of Elf-4 into stem/progenitor and erythroid regulatory networks through locus-wide chromatin studies coupled with in vivo functional validation. Mol Cell Biol. 2012;32:763-73 pubmed publisher
    ..1, Fli-1, and Erg were bound to the -10E element, and mutation of three highly conserved ETS sites within the enhancer abolished its ..
  3. Wilson N, Foster S, Wang X, Knezevic K, Schütte J, Kaimakis P, et al. Combinatorial transcriptional control in blood stem/progenitor cells: genome-wide analysis of ten major transcriptional regulators. Cell Stem Cell. 2010;7:532-44 pubmed publisher
    ..1, ERG, FLI-1, and GFI1B), thus providing the most comprehensive TF data set for any adult stem/progenitor cell type to ..
  4. Tang J, Carmichael C, Shi W, Metcalf D, Ng A, Hyland C, et al. Transposon mutagenesis reveals cooperation of ETS family transcription factors with signaling pathways in erythro-megakaryocytic leukemia. Proc Natl Acad Sci U S A. 2013;110:6091-6 pubmed publisher
    ..The genes encoding the E-twenty-six (ETS) transcription factors Ets related gene (Erg) and Ets1 were the most common sites for transposon insertion in SB-induced JAK2V617F-positive erythroleukemias, ..
  5. Nguyen L, Tretiakova M, Silvis M, Lucas J, Klezovitch O, Coleman I, et al. ERG Activates the YAP1 Transcriptional Program and Induces the Development of Age-Related Prostate Tumors. Cancer Cell. 2015;27:797-808 pubmed publisher
    The significance of ERG in human prostate cancer is unclear because mouse prostate is resistant to ERG-mediated transformation...
  6. Ng A, Hyland C, Metcalf D, Carmichael C, Loughran S, Di Rago L, et al. Trisomy of Erg is required for myeloproliferation in a mouse model of Down syndrome. Blood. 2010;115:3966-9 pubmed publisher
    ..Using a loss-of-function allele, we show that specific reduction to functional disomy of the Erg gene corrects the pathologic and hematologic features of myeloproliferation in the Ts(17(16))65Dn mouse model of ..
  7. Dufton N, Peghaire C, Osuna Almagro L, Raimondi C, Kalna V, Chuahan A, et al. Dynamic regulation of canonical TGFβ signalling by endothelial transcription factor ERG protects from liver fibrogenesis. Nat Commun. 2017;8:895 pubmed publisher
    ..Here we describe how the endothelial transcription factor ETS-related gene (ERG) promotes liver homoeostasis by controlling canonical TGFβ-SMAD signalling, driving the SMAD1 pathway while ..
  8. Fish J, Cantu Gutierrez M, Dang L, Khyzha N, Chen Z, Veitch S, et al. Dynamic regulation of VEGF-inducible genes by an ERK/ERG/p300 transcriptional network. Development. 2017;144:2428-2444 pubmed publisher
    ..Furthermore, VEGF/ERK signaling induces phosphorylation and activation of the ETS transcription factor ERG, a prerequisite for DLL4 induction...
  9. Ng A, Loughran S, Metcalf D, Hyland C, de Graaf C, Hu Y, et al. Erg is required for self-renewal of hematopoietic stem cells during stress hematopoiesis in mice. Blood. 2011;118:2454-61 pubmed publisher
    ..b>Erg, a member of the Ets family of transcription factors, is deregulated in cancers; and although Erg is known to be ..
  10. Groman Lupa S, Adewumi J, Park K, Brzezinski J. The Transcription Factor Prdm16 Marks a Single Retinal Ganglion Cell Subtype in the Mouse Retina. Invest Ophthalmol Vis Sci. 2017;58:5421-5433 pubmed publisher
    ..Future studies are needed to determine the function of these ganglion cells and whether Prdm16 regulates their development. ..
  11. Arnold T, Niaudet C, Pang M, Siegenthaler J, Gaengel K, Jung B, et al. Excessive vascular sprouting underlies cerebral hemorrhage in mice lacking αVβ8-TGFβ signaling in the brain. Development. 2014;141:4489-99 pubmed publisher
    ..Our data therefore suggest that abnormal vascular sprouting and patterning, not BBB dysfunction, underlie developmental cerebral hemorrhage. ..
  12. Cox M, Appelboom B, Ban G, Serra R. Erg cooperates with TGF-? to control mesenchymal differentiation. Exp Cell Res. 2014;328:410-8 pubmed publisher
    ..The transcription factor avian erythroblastosis virus E-26 (v-ets) oncogene related (Erg) was identified in the microarray screen as a candidate regulator of AF development...
  13. Abedin M, Nguyen A, Jiang N, Perry C, Shelton J, Watson D, et al. Fli1 acts downstream of Etv2 to govern cell survival and vascular homeostasis via positive autoregulation. Circ Res. 2014;114:1690-9 pubmed publisher
    ..Once the program is activated in early embryos, Fli1 then takes over to sustain the process in the absence of Etv2. ..
  14. Wei G, Badis G, Berger M, Kivioja T, Palin K, Enge M, et al. Genome-wide analysis of ETS-family DNA-binding in vitro and in vivo. EMBO J. 2010;29:2147-60 pubmed publisher
    ..reveal that the ETS-binding profiles cluster into four distinct classes, and that all ETS factors linked to cancer, ERG, ETV1, ETV4 and FLI1, fall into just one of these classes...
  15. Cabin D, McKee Johnson J, Matesic L, Wiltshire T, Rue E, Mjaatvedt A, et al. Physical and comparative mapping of distal mouse chromosome 16. 5 p5. Genome Res. 1998;8:940-50 pubmed
    ..Comparison of this physical map with that of the corresponding region on Chr. 21 shows conservation not only of gene order but of size in the 3 Mb from Cbr1 to Ets2; distal to Ets2, the human map is expanded. ..
  16. Mjaatvedt A, Citron M, Reeves R. High-resolution mapping of D16led-1, Gart, Gas-4, Cbr, Pcp-4, and Erg on distal mouse chromosome 16. Genomics. 1993;17:382-6 pubmed
    ..including previously mapped reference markers, is (cen)-D16H21S16-D16Led-1-App-Sod-1-Gart-Gas-4-Cbr++ +-wv-Pcp-4-Erg-Ets-2. This gene order recapitulates the order of the genes on human chromosome 21 where known...
  17. Ohta Y, Okabe T, Larmour C, Di Rocco A, Maijenburg M, Phillips A, et al. Articular cartilage endurance and resistance to osteoarthritic changes require transcription factor Erg. Arthritis Rheumatol. 2015;67:2679-90 pubmed publisher
    To determine whether and how the transcription factor Erg participates in the genesis, establishment, and maintenance of articular cartilage...
  18. Wang X, Chen D, Chen K, Jubran A, Ramirez A, Astrof S. Endothelium in the pharyngeal arches 3, 4 and 6 is derived from the second heart field. Dev Biol. 2017;421:108-117 pubmed publisher
    ..Taken together, our studies establish a platform for investigating cellular and molecular mechanisms regulating PAA formation and alterations that lead to disease. ..
  19. Malinverno M, Corada M, Ferrarini L, Formicola L, Marazzi G, Sassoon D, et al. Peg3/PW1 Is a Marker of a Subset of Vessel Associated Endothelial Progenitors. Stem Cells. 2017;35:1328-1340 pubmed publisher
    ..Considering their high proliferative potential these cells may be of particular importance to design therapies to improve the perfusion of ischemic tissues or to promote vascular repair. Stem Cells 2017;35:1328-1340. ..
  20. Chang A, Raftrey B, D Amato G, Surya V, Poduri A, Chen H, et al. DACH1 stimulates shear stress-guided endothelial cell migration and coronary artery growth through the CXCL12-CXCR4 signaling axis. Genes Dev. 2017;31:1308-1324 pubmed publisher
    ..This activity is suppressed once arteries reach a mature morphology and acquire high, laminar flow that down-regulates DACH1. Thus, we identified a mechanism by which blood flow quality balances artery growth and maturation. ..
  21. Blanco M, Rodriguez Martin I, Learte A, Clemente C, Montalvo M, Seiki M, et al. Developmental expression of membrane type 4-matrix metalloproteinase (Mt4-mmp/Mmp17) in the mouse embryo. PLoS ONE. 2017;12:e0184767 pubmed publisher
    ..Our data point to distinct functions for this metalloproteinase during embryonic development, particularly during brain formation, angiogenesis and limb development. ..
  22. Reddy E, Rao V, Papas T. The erg gene: a human gene related to the ets oncogene. Proc Natl Acad Sci U S A. 1987;84:6131-5 pubmed
    We have isolated a cDNA clone representing the complete coding sequence of a human gene named erg, related to the ets oncogene. Nucleotide sequence analysis of this cDNA (4...
  23. Mjaatvedt A, Cabin D, Cole S, Long L, Breitwieser G, Reeves R. Assessment of a mutation in the H5 domain of Girk2 as a candidate for the weaver mutation. Genome Res. 1995;5:453-63 pubmed
    ..This suggests that if the Girk2 mutation is responsible for the wv phenotype, it does not act by altering these electrical properties of developing GCs. ..
  24. Yang L, Xia L, Wu D, Wang H, Chansky H, Schubach W, et al. Molecular cloning of ESET, a novel histone H3-specific methyltransferase that interacts with ERG transcription factor. Oncogene. 2002;21:148-52 pubmed
    The ets-related gene erg encodes a transcription factor that is implicated in the control of cell growth and differentiation...
  25. Nohata N, Uchida Y, Stratman A, Adams R, Zheng Y, Weinstein B, et al. Temporal-specific roles of Rac1 during vascular development and retinal angiogenesis. Dev Biol. 2016;411:183-194 pubmed publisher
    ..Hence, Rac1 and its downstream molecules may represent potential anti-angiogeneic therapeutic targets for the treatment of many human diseases that involve aberrant neovascularization and blood vessel overgrowth. ..
  26. Chen Y, Chi P, Rockowitz S, Iaquinta P, Shamu T, Shukla S, et al. ETS factors reprogram the androgen receptor cistrome and prime prostate tumorigenesis in response to PTEN loss. Nat Med. 2013;19:1023-9 pubmed publisher
    ..Here we describe a new conditional mouse model that shows robust, homogenous ERG expression throughout the prostate...
  27. Koyama E, Ochiai T, Rountree R, Kingsley D, Enomoto Iwamoto M, Iwamoto M, et al. Synovial joint formation during mouse limb skeletogenesis: roles of Indian hedgehog signaling. Ann N Y Acad Sci. 2007;1116:100-12 pubmed
    ..joints expressed hedgehog target genes including Gli1 and Gli2 and interzone-associated genes including Gdf5, Erg, and tenascin-C, but expression of all these genes was barely detectable in mutant joints...
  28. Diffner E, Beck D, Gudgin E, Thoms J, Knezevic K, Pridans C, et al. Activity of a heptad of transcription factors is associated with stem cell programs and clinical outcome in acute myeloid leukemia. Blood. 2013;121:2289-300 pubmed publisher
    ..Ets Related Gene (ERG) is a component of normal and leukemic stem cell signatures and high ERG expression is a risk factor for poor ..
  29. Birdsey G, Shah A, Dufton N, Reynolds L, Osuna Almagro L, Yang Y, et al. The endothelial transcription factor ERG promotes vascular stability and growth through Wnt/β-catenin signaling. Dev Cell. 2015;32:82-96 pubmed publisher
    ..The ETS transcription factor ERG drives expression of VE-cadherin and controls junctional integrity...
  30. Lee S, Lee S, Yang H, Song S, Kim K, Saunders T, et al. Notch pathway targets proangiogenic regulator Sox17 to restrict angiogenesis. Circ Res. 2014;115:215-26 pubmed publisher
    ..Our findings demonstrate that the Notch pathway restricts sprouting angiogenesis by reducing the expression of proangiogenic regulator Sox17. ..
  31. Cironi L, Riggi N, Provero P, Wolf N, Suva M, Suva D, et al. IGF1 is a common target gene of Ewing's sarcoma fusion proteins in mesenchymal progenitor cells. PLoS ONE. 2008;3:e2634 pubmed publisher
    ..chimeric genes encoding EWS or FUS fused to one of several ets transcription factor family members, including ERG-1, FEV, ETV1 and ETV6...
  32. Mounir Z, Lin F, Lin V, Korn J, Yu Y, Valdez R, et al. TMPRSS2:ERG blocks neuroendocrine and luminal cell differentiation to maintain prostate cancer proliferation. Oncogene. 2015;34:3815-25 pubmed publisher
    The biological outcome of TMPRSS2:ERG chromosomal translocations in prostate cancer (PC) remains poorly understood...
  33. Mundy C, Yasuda T, Kinumatsu T, Yamaguchi Y, Iwamoto M, Enomoto Iwamoto M, et al. Synovial joint formation requires local Ext1 expression and heparan sulfate production in developing mouse embryo limbs and spine. Dev Biol. 2011;351:70-81 pubmed publisher
    ..The data indicate also that defects in joint formation reverberate on, and delay, overall long bone growth. ..
  34. Han R, Pacifici M, Iwamoto M, Trojanowska M. Endothelial Erg expression is required for embryogenesis and vascular integrity. Organogenesis. 2015;11:75-86 pubmed publisher
    ..The family member Erg is highly expressed in endothelial cells as compared to other developing cell types including chondrocytes, ..
  35. Giampietro C, Deflorian G, Gallo S, di Matteo A, Pradella D, Bonomi S, et al. The alternative splicing factor Nova2 regulates vascular development and lumen formation. Nat Commun. 2015;6:8479 pubmed publisher
    ..Collectively, our results reveal that Nova2 functions as an AS regulator in angiogenesis and is a novel member of the 'angioneurins' family. ..
  36. Howard M, Tuan R, Wallis G. The function and interrelationship between GDF5 and ERG-010 during chondrogenesis in vitro. In Vitro Cell Dev Biol Anim. 2016;52:182-92 pubmed publisher
    ..Both GDF5 and ERG are proposed as regulators of chondrocyte differentiation during and post interzone formation...
  37. Tamamura Y, Otani T, Kanatani N, Koyama E, Kitagaki J, Komori T, et al. Developmental regulation of Wnt/beta-catenin signals is required for growth plate assembly, cartilage integrity, and endochondral ossification. J Biol Chem. 2005;280:19185-95 pubmed
  38. Guo H, Kazadaeva Y, Ortega F, Manjunath N, Desai T. Trinucleotide repeat containing 6c (TNRC6c) is essential for microvascular maturation during distal airspace sacculation in the developing lung. Dev Biol. 2017;430:214-223 pubmed publisher
    ..These results imply a complex and indirect mode of regulation of sacculation by TNRC6c, mediated in part by dynamic transcriptional repression of an inhibitor of TGF? family gene expression. ..
  39. Salek Ardakani S, Smooha G, de Boer J, Sebire N, Morrow M, Rainis L, et al. ERG is a megakaryocytic oncogene. Cancer Res. 2009;69:4665-73 pubmed publisher
    Ets-related gene (ERG) is a member of the ETS transcription factor gene family located on Hsa21. ERG is known to have a crucial role in establishing definitive hematopoiesis and is required for normal megakaryopoiesis...
  40. Dy P, Smits P, Silvester A, Penzo Méndez A, Dumitriu B, Han Y, et al. Synovial joint morphogenesis requires the chondrogenic action of Sox5 and Sox6 in growth plate and articular cartilage. Dev Biol. 2010;341:346-59 pubmed publisher
    ..Sox5 and Sox6 restricted expression to chondrocytes in wild-type embryos and continued Erg expression and weak Ihh expression in Sox5(-/-)6(-/-) growth plates suggest that growth plate failure contribute to ..
  41. Cossette S, Misra R. The identification of different endothelial cell populations within the mouse proepicardium. Dev Dyn. 2011;240:2344-53 pubmed publisher
    ..These findings indicate that EC exist in the proepicardium before coronary vasculogenesis, and support a model in which there is a heterogeneous origin for EC in the proepicardium. ..
  42. Flajollet S, Tian T, Huot L, Tomavo N, Flourens A, Holder Espinasse M, et al. Increased adipogenesis in cultured embryonic chondrocytes and in adult bone marrow of dominant negative Erg transgenic mice. PLoS ONE. 2012;7:e48656 pubmed publisher
    ..The Ets transcription factor family may be involved in skeletal development. One family member, the Erg gene, is mainly expressed during cartilage formation...
  43. Lathen C, Zhang Y, Chow J, Singh M, Lin G, Nigam V, et al. ERG-APLNR axis controls pulmonary venule endothelial proliferation in pulmonary veno-occlusive disease. Circulation. 2014;130:1179-91 pubmed publisher
    ..We show that mice with homozygous deletion of the Ets transcription factor Erg die between embryonic day 16...
  44. Tsuzuki S, Taguchi O, Seto M. Promotion and maintenance of leukemia by ERG. Blood. 2011;117:3858-68 pubmed publisher
    The Ets-related gene (ERG) located on human chromosome 21 encodes a transcription factor and is thought to be causally related to Down syndrome-associated acute megakaryocytic leukemia in childhood...
  45. Thoms J, Birger Y, Foster S, Knezevic K, Kirschenbaum Y, Chandrakanthan V, et al. ERG promotes T-acute lymphoblastic leukemia and is transcriptionally regulated in leukemic cells by a stem cell enhancer. Blood. 2011;117:7079-89 pubmed publisher
    The Ets-related gene (ERG) is an Ets-transcription factor required for normal blood stem cell development...
  46. Looney A, Han R, Stawski L, Marden G, Iwamoto M, Trojanowska M. Synergistic Role of Endothelial ERG and FLI1 in Mediating Pulmonary Vascular Homeostasis. Am J Respir Cell Mol Biol. 2017;57:121-131 pubmed publisher
    ..member, Friend leukemia integration 1 transcription factor (FLI1), and its closest homolog, ETS-related gene (ERG), are associated with PAH...
  47. Carmichael C, Metcalf D, Henley K, Kruse E, Di Rago L, Mifsud S, et al. Hematopoietic overexpression of the transcription factor Erg induces lymphoid and erythro-megakaryocytic leukemia. Proc Natl Acad Sci U S A. 2012;109:15437-42 pubmed
    The transcription factor encoded by the E-twenty-six (ETS)-related gene, ERG, is an essential regulator of hematopoietic stem cell function and a potent human oncoprotein...
  48. Mohamed A, Tan S, Mikhalkevich N, Ponniah S, Vasioukhin V, Bieberich C, et al. Ets family protein, erg expression in developing and adult mouse tissues by a highly specific monoclonal antibody. J Cancer. 2010;1:197-208 pubmed
    Oncogenic activation of the ETS Related Gene (ERG) in humans was originally identified in subsets of Ewing sarcomas, myeloid leukemias and, recently, in the majority of prostate cancers...
  49. Li P, Ninomiya H, Kurata Y, Kato M, Miake J, Yamamoto Y, et al. Reciprocal control of hERG stability by Hsp70 and Hsc70 with implication for restoration of LQT2 mutant stability. Circ Res. 2011;108:458-68 pubmed publisher
    ..Heat shock treatment of HL-1 mouse cardiomyocytes induced endogenous Hsp70, switched mouse ERG associated with Hsc70 to Hsp70, increased I(Kr), and shortened action potential duration...
  50. Fan C, Kuwana E, Bulfone A, Fletcher C, Copeland N, Jenkins N, et al. Expression patterns of two murine homologs of Drosophila single-minded suggest possible roles in embryonic patterning and in the pathogenesis of Down syndrome. Mol Cell Neurosci. 1996;7:1-16 pubmed
    ..Our data suggest that the Sim genes play roles in directing the regionalization of tissues where they are expressed. Moreover, the expression pattern documented for Sim2 may provide insights into its potential roles in Down syndrome. ..
  51. Kueh A, Dixon M, Voss A, Thomas T. HBO1 is required for H3K14 acetylation and normal transcriptional activity during embryonic development. Mol Cell Biol. 2011;31:845-60 pubmed publisher
    ..In conclusion, the primary role of HBO1 in development is that of a transcriptional activator, which is indispensable for H3K14 acetylation and for the normal expression of essential genes regulating embryonic development. ..
  52. Lacko L, Hurtado R, Hinds S, Poulos M, Butler J, Stuhlmann H. Altered feto-placental vascularization, feto-placental malperfusion and fetal growth restriction in mice with Egfl7 loss of function. Development. 2017;144:2469-2479 pubmed publisher
  53. Xie Y, Koch M, Zhang X, Hamblen M, Godinho F, Fujiwara Y, et al. Reduced Erg Dosage Impairs Survival of Hematopoietic Stem and Progenitor Cells. Stem Cells. 2017;35:1773-1785 pubmed publisher
    b>ERG, an ETS family transcription factor frequently overexpressed in human leukemia, has been implicated as a key regulator of hematopoietic stem cells...
  54. Aranda Orgilles B, Saldaña Meyer R, Wang E, Trompouki E, Fassl A, Lau S, et al. MED12 Regulates HSC-Specific Enhancers Independently of Mediator Kinase Activity to Control Hematopoiesis. Cell Stem Cell. 2016;19:784-799 pubmed publisher
    ..As MED12 mutations have been described recently in blood malignancies, alterations in MED12-dependent enhancer regulation may control both physiological and malignant hematopoiesis. ..
  55. Liu F, Li D, Yu Y, Kang I, Cha M, Kim J, et al. Induction of hematopoietic and endothelial cell program orchestrated by ETS transcription factor ER71/ETV2. EMBO Rep. 2015;16:654-69 pubmed publisher
    ..These findings highlight the critical role that transient ETV2 expression plays in the regulation of hematopoietic and endothelial cell lineage specification and stability. ..
  56. Lawson K, Teteak C, Zou J, Hacquebord J, Ghatan A, Zielinska Kwiatkowska A, et al. Mesenchyme-specific knockout of ESET histone methyltransferase causes ectopic hypertrophy and terminal differentiation of articular chondrocytes. J Biol Chem. 2013;288:32119-25 pubmed publisher
    ..In this study, we have found that ESET (an ERG-associated protein with a SET domain, also called SETDB1) histone methyltransferase is expressed in articular ..
  57. Kolander K, Holtz M, Cossette S, Duncan S, Misra R. Epicardial GATA factors regulate early coronary vascular plexus formation. Dev Biol. 2014;386:204-15 pubmed publisher
    ..Here we present evidence for a novel role for epicardial GATA factors in controlling plexus formation by recruiting endothelial cells to the sub-epicardium. ..
  58. Le Bras A, Samson C, Trentini M, Caetano B, Lelievre E, Mattot V, et al. VE-statin/egfl7 expression in endothelial cells is regulated by a distal enhancer and a proximal promoter under the direct control of Erg and GATA-2. PLoS ONE. 2010;5:e12156 pubmed publisher
    ..An analysis of expression of the ETS and GATA transcription factors showed that Erg, Fli-1 and GATA-2 are the most highly expressed factors in endothelial cells...
  59. Knudsen K, Rehn M, Hasemann M, Rapin N, Bagger F, Ohlsson E, et al. ERG promotes the maintenance of hematopoietic stem cells by restricting their differentiation. Genes Dev. 2015;29:1915-29 pubmed publisher
    ..In the present work, we identify ETS (E-twenty-six)-related gene (ERG) as a critical factor protecting HSCs from differentiation...
  60. Iwamoto M, Koyama E, Enomoto Iwamoto M, Pacifici M. The balancing act of transcription factors C-1-1 and Runx2 in articular cartilage development. Biochem Biophys Res Commun. 2005;328:777-82 pubmed
    ..The factors are powerful chondrocyte regulators and their functional interrelationships may be important for steering the cells toward alternative developmental paths. ..
  61. Pan J, Zou J, Wu D, Roberson R, Hennings L, Ma X, et al. TLS-ERG leukemia fusion protein deregulates cyclin-dependent kinase 1 and blocks terminal differentiation of myeloid progenitor cells. Mol Cancer Res. 2008;6:862-72 pubmed publisher
    TLS-ERG fusion protein is derived from the t(16;21) translocation found in human myeloid leukemia...
  62. Baena E, Shao Z, Linn D, Glass K, Hamblen M, Fujiwara Y, et al. ETV1 directs androgen metabolism and confers aggressive prostate cancer in targeted mice and patients. Genes Dev. 2013;27:683-98 pubmed publisher
    ..Chromosomal rearrangements involving ETS transcription factors, such as ERG and ETV1, occur frequently in prostate cancer...
  63. Ng A, Hu Y, Metcalf D, Hyland C, Ierino H, Phipson B, et al. Early lineage priming by trisomy of Erg leads to myeloproliferation in a Down syndrome model. PLoS Genet. 2015;11:e1005211 pubmed publisher
    ..Trisomy of the Erg gene is required for myeloproliferation in the Ts(1716)65Dn DS mouse model...
  64. Sims Lucas S, Schaefer C, Bushnell D, Ho J, Logar A, Prochownik E, et al. Endothelial Progenitors Exist within the Kidney and Lung Mesenchyme. PLoS ONE. 2013;8:e65993 pubmed publisher
  65. Gardner H, Wertheim G, Ha S, Copeland N, Gilbert D, Jenkins N, et al. Cloning and characterization of Hunk, a novel mammalian SNF1-related protein kinase. Genomics. 2000;63:46-59 pubmed
    ..Moreover, in situ hybridization analysis reveals that Hunk expression is restricted to subsets of cells within a variety of organs in the adult mouse. These findings suggest a role for Hunk in murine development. ..
  66. Chen H, Poduri A, Numi H, Kivela R, Saharinen P, McKay A, et al. VEGF-C and aortic cardiomyocytes guide coronary artery stem development. J Clin Invest. 2014;124:4899-914 pubmed publisher
    ..Studying this niche for cardiomyocyte development, and its relationship with CAs, has the potential to identify methods for stimulating vascular regrowth as a treatment for cardiovascular disease. ..
  67. Stankiewicz M, Crispino J. ETS2 and ERG promote megakaryopoiesis and synergize with alterations in GATA-1 to immortalize hematopoietic progenitor cells. Blood. 2009;113:3337-47 pubmed publisher
    ETS2 and ERG are transcription factors, encoded on human chromosome 21 (Hsa21), that have been implicated in human cancer...