Gene Symbol: Erfe
Description: erythroferrone
Alias: 4832406C22, Fam132b, myonectin, erythroferrone, complement C1q tumor necrosis factor-related protein 15, family with sequence similarity 132, member B, protein FAM132B
Species: mouse
Products:     Erfe

Top Publications

  1. Seldin M, Peterson J, Byerly M, Wei Z, Wong G. Myonectin (CTRP15), a novel myokine that links skeletal muscle to systemic lipid homeostasis. J Biol Chem. 2012;287:11968-80 pubmed publisher
    ..Here, we report the identification and characterization of myonectin, a novel myokine belonging to the C1q/TNF-related protein (CTRP) family...
  2. Seldin M, Lei X, Tan S, Stanson K, Wei Z, Wong G. Skeletal muscle-derived myonectin activates the mammalian target of rapamycin (mTOR) pathway to suppress autophagy in liver. J Biol Chem. 2013;288:36073-82 pubmed publisher
    ..Here, we provide evidence that myonectin (CTRP15), a skeletal muscle-derived myokine, is a novel regulator of cellular autophagy...
  3. Kautz L, Jung G, Du X, Gabayan V, Chapman J, Nasoff M, et al. Erythroferrone contributes to hepcidin suppression and iron overload in a mouse model of β-thalassemia. Blood. 2015;126:2031-7 pubmed publisher
    ..b>Erythroferrone (ERFE) is an erythroid regulator of hepcidin synthesis and iron homeostasis...
  4. Jiang X, Gao M, Chen Y, Liu J, Qi S, Ma J, et al. EPO-dependent induction of erythroferrone drives hepcidin suppression and systematic iron absorption under phenylhydrazine-induced hemolytic anemia. Blood Cells Mol Dis. 2016;58:45-51 pubmed publisher
    ..Mirrored with serum EPO concentration, the mRNA expression of erythroferrone (ERFE) was rapidly increased in the bone marrow and spleen 3days after injection of PHZ, and then gradually ..
  5. Kautz L, Jung G, Valore E, Rivella S, Nemeth E, Ganz T. Identification of erythroferrone as an erythroid regulator of iron metabolism. Nat Genet. 2014;46:678-84 pubmed publisher
    ..We identified a new hormone, erythroferrone (ERFE), that mediates hepcidin suppression during stress erythropoiesis...
  6. Kautz L, Jung G, Nemeth E, Ganz T. Erythroferrone contributes to recovery from anemia of inflammation. Blood. 2014;124:2569-74 pubmed publisher
    b>Erythroferrone (ERFE) is an erythropoiesis-driven regulator of iron homeostasis. ERFE mediates the suppression of the iron-regulatory hormone hepcidin to increase iron absorption and mobilization of iron from stores...
  7. Latour C, Wlodarczyk M, Jung G, Gineste A, Blanchard N, Ganz T, et al. Erythroferrone contributes to hepcidin repression in a mouse model of malarial anemia. Haematologica. 2017;102:60-68 pubmed publisher
    ..production was reduced concomitantly to an increase in the messenger RNA expression of the hepcidin suppressor erythroferrone in the bone marrow and the spleen...
  8. Aschemeyer S, Gabayan V, Ganz T, Nemeth E, Kautz L. Erythroferrone and matriptase-2 independently regulate hepcidin expression. Am J Hematol. 2017;92:E61-E63 pubmed publisher
  9. Frýdlová J, Rychtarčíková Z, Gurieva I, Vokurka M, Truksa J, Krijt J. Effect of erythropoietin administration on proteins participating in iron homeostasis in Tmprss6-mutated mask mice. PLoS ONE. 2017;12:e0186844 pubmed publisher
    ..At the protein level, erythropoietin increased the amount of splenic erythroferrone and transferrin receptor 2 both in C57BL/6 and mask mice...

More Information


  1. Pasricha S, Lim P, Duarte T, Casu C, Oosterhuis D, Mleczko Sanecka K, et al. Hepcidin is regulated by promoter-associated histone acetylation and HDAC3. Nat Commun. 2017;8:403 pubmed publisher
    ..Erythropoiesis and iron deficiency suppress hepcidin via erythroferrone-dependent and -independent mechanisms, respectively, in vivo, but both involve reversible loss of H3K9ac and ..