Erbin

Summary

Gene Symbol: Erbin
Description: Erbb2 interacting protein
Alias: 1700028E05Rik, Erbb2ip, mKIAA1225, erbin, densin-180-like protein, erbb2-interacting protein, protein LAP2
Species: mouse
Products:     Erbin

Top Publications

  1. Borg J, Marchetto S, Le Bivic A, Ollendorff V, Jaulin Bastard F, Saito H, et al. ERBIN: a basolateral PDZ protein that interacts with the mammalian ERBB2/HER2 receptor. Nat Cell Biol. 2000;2:407-14 pubmed
    ..We have identified a new PDZ protein we named ERBIN (ERBB2 interacting protein) that acts as an adaptor for the receptor ERBB2/HER2 in epithelia...
  2. Rangwala R, Banine F, Borg J, Sherman L. Erbin regulates mitogen-activated protein (MAP) kinase activation and MAP kinase-dependent interactions between Merlin and adherens junction protein complexes in Schwann cells. J Biol Chem. 2005;280:11790-7 pubmed
    ..Here, we find that a novel PDZ protein, called erbin, binds directly to the merlin-binding partner, EBP0, and regulates adherens junction dissociation through a MAP ..
  3. Tao Y, Dai P, Liu Y, Marchetto S, Xiong W, Borg J, et al. Erbin regulates NRG1 signaling and myelination. Proc Natl Acad Sci U S A. 2009;106:9477-82 pubmed publisher
    ..However, little is known about regulatory mechanisms of NRG1 signaling. We show here that Erbin, a protein that contains leucine-rich repeats (LRR) and a PSD95-Dlg-Zol (PDZ) domain and that interacts ..
  4. Liang C, Tao Y, Shen C, Tan Z, Xiong W, Mei L. Erbin is required for myelination in regenerated axons after injury. J Neurosci. 2012;32:15169-80 pubmed publisher
    ..In this study, we investigated the role of Erbin, a protein that interacts with ErbB2 in remyelination of injured nerves...
  5. Huang Y, Wang Q, Xiong W, Mei L. Erbin is a protein concentrated at postsynaptic membranes that interacts with PSD-95. J Biol Chem. 2001;276:19318-26 pubmed
    ..Using as bait the ErbB2 C terminus, we identified Erbin, another PDZ domain-containing protein that interacts specifically with ErbB2...
  6. Tao Y, Chen Y, Shen C, Luo Z, Bates C, Lee D, et al. Erbin interacts with TARP ?-2 for surface expression of AMPA receptors in cortical interneurons. Nat Neurosci. 2013;16:290-9 pubmed publisher
    ..Here we demonstrate that Erbin is specifically expressed in cortical inhibitory neurons...
  7. Warner D, Pisano M, Roberts E, Greene R. Identification of three novel Smad binding proteins involved in cell polarity. FEBS Lett. 2003;539:167-73 pubmed
    ..Three proteins (Erbin, Par-3, and Dishevelled) were identified that share several similar structural and functional characteristics...
  8. Rachmin I, Amsalem E, Golomb E, Beeri R, Gilon D, Fang P, et al. FHL2 switches MITF from activator to repressor of Erbin expression during cardiac hypertrophy. Int J Cardiol. 2015;195:85-94 pubmed publisher
    ..Gene array analysis of hearts from MITF-mutated mice indicated that ErbB2 interacting protein (Erbin) is a candidate target gene for MITF...
  9. Yao S, Zheng P, Wu H, Song L, Ying X, Xing C, et al. Erbin interacts with c-Cbl and promotes tumourigenesis and tumour growth in colorectal cancer by preventing c-Cbl-mediated ubiquitination and down-regulation of EGFR. J Pathol. 2015;236:65-77 pubmed publisher
    ..Here, we found that Erbin, a member of the leucine-rich repeat and PDZ domain (LAP) family, plays a key role in EGFR signalling...
  10. Arikkath J, Israely I, Tao Y, Mei L, Liu X, Reichardt L. Erbin controls dendritic morphogenesis by regulating localization of delta-catenin. J Neurosci. 2008;28:7047-56 pubmed publisher
    The LAP [leucine-rich and postsynaptic density-95/Discs large/zona occludens-1 (PDZ)] protein erbin and delta-catenin, a component of the cadherin-catenin cell adhesion complex, are highly expressed in neurons and associate through PDZ-..

Detail Information

Publications19

  1. Borg J, Marchetto S, Le Bivic A, Ollendorff V, Jaulin Bastard F, Saito H, et al. ERBIN: a basolateral PDZ protein that interacts with the mammalian ERBB2/HER2 receptor. Nat Cell Biol. 2000;2:407-14 pubmed
    ..We have identified a new PDZ protein we named ERBIN (ERBB2 interacting protein) that acts as an adaptor for the receptor ERBB2/HER2 in epithelia...
  2. Rangwala R, Banine F, Borg J, Sherman L. Erbin regulates mitogen-activated protein (MAP) kinase activation and MAP kinase-dependent interactions between Merlin and adherens junction protein complexes in Schwann cells. J Biol Chem. 2005;280:11790-7 pubmed
    ..Here, we find that a novel PDZ protein, called erbin, binds directly to the merlin-binding partner, EBP0, and regulates adherens junction dissociation through a MAP ..
  3. Tao Y, Dai P, Liu Y, Marchetto S, Xiong W, Borg J, et al. Erbin regulates NRG1 signaling and myelination. Proc Natl Acad Sci U S A. 2009;106:9477-82 pubmed publisher
    ..However, little is known about regulatory mechanisms of NRG1 signaling. We show here that Erbin, a protein that contains leucine-rich repeats (LRR) and a PSD95-Dlg-Zol (PDZ) domain and that interacts ..
  4. Liang C, Tao Y, Shen C, Tan Z, Xiong W, Mei L. Erbin is required for myelination in regenerated axons after injury. J Neurosci. 2012;32:15169-80 pubmed publisher
    ..In this study, we investigated the role of Erbin, a protein that interacts with ErbB2 in remyelination of injured nerves...
  5. Huang Y, Wang Q, Xiong W, Mei L. Erbin is a protein concentrated at postsynaptic membranes that interacts with PSD-95. J Biol Chem. 2001;276:19318-26 pubmed
    ..Using as bait the ErbB2 C terminus, we identified Erbin, another PDZ domain-containing protein that interacts specifically with ErbB2...
  6. Tao Y, Chen Y, Shen C, Luo Z, Bates C, Lee D, et al. Erbin interacts with TARP ?-2 for surface expression of AMPA receptors in cortical interneurons. Nat Neurosci. 2013;16:290-9 pubmed publisher
    ..Here we demonstrate that Erbin is specifically expressed in cortical inhibitory neurons...
  7. Warner D, Pisano M, Roberts E, Greene R. Identification of three novel Smad binding proteins involved in cell polarity. FEBS Lett. 2003;539:167-73 pubmed
    ..Three proteins (Erbin, Par-3, and Dishevelled) were identified that share several similar structural and functional characteristics...
  8. Rachmin I, Amsalem E, Golomb E, Beeri R, Gilon D, Fang P, et al. FHL2 switches MITF from activator to repressor of Erbin expression during cardiac hypertrophy. Int J Cardiol. 2015;195:85-94 pubmed publisher
    ..Gene array analysis of hearts from MITF-mutated mice indicated that ErbB2 interacting protein (Erbin) is a candidate target gene for MITF...
  9. Yao S, Zheng P, Wu H, Song L, Ying X, Xing C, et al. Erbin interacts with c-Cbl and promotes tumourigenesis and tumour growth in colorectal cancer by preventing c-Cbl-mediated ubiquitination and down-regulation of EGFR. J Pathol. 2015;236:65-77 pubmed publisher
    ..Here, we found that Erbin, a member of the leucine-rich repeat and PDZ domain (LAP) family, plays a key role in EGFR signalling...
  10. Arikkath J, Israely I, Tao Y, Mei L, Liu X, Reichardt L. Erbin controls dendritic morphogenesis by regulating localization of delta-catenin. J Neurosci. 2008;28:7047-56 pubmed publisher
    The LAP [leucine-rich and postsynaptic density-95/Discs large/zona occludens-1 (PDZ)] protein erbin and delta-catenin, a component of the cadherin-catenin cell adhesion complex, are highly expressed in neurons and associate through PDZ-..
  11. Kravic B, Huraskin D, Frick A, Jung J, Redai V, Palmisano R, et al. LAP proteins are localized at the post-synaptic membrane of neuromuscular junctions and appear to modulate synaptic morphology and transmission. J Neurochem. 2016;139:381-395 pubmed publisher
    b>Erbin, Lano, Scribble, and Densin-180 belong to LAP (leucine-rich repeats and PDZ domain) adaptor proteins involved in cell signaling pathways...
  12. Rachmin I, Tshori S, Smith Y, Oppenheim A, Marchetto S, Kay G, et al. Erbin is a negative modulator of cardiac hypertrophy. Proc Natl Acad Sci U S A. 2014;111:5902-7 pubmed publisher
    b>ErbB2 interacting protein (Erbin) is a widely expressed protein and participates in inhibition of several intracellular signaling pathways. Its mRNA has been found to be present in relatively high levels in the heart...
  13. Simeone L, Straubinger M, Khan M, Nalleweg N, Cheusova T, Hashemolhosseini S. Identification of Erbin interlinking MuSK and ErbB2 and its impact on acetylcholine receptor aggregation at the neuromuscular junction. J Neurosci. 2010;30:6620-34 pubmed publisher
    b>Erbin, a binding partner of ErbB2, was identified as the first member of the LAP family of proteins...
  14. McDonald C, Chen F, Ollendorff V, Ogura Y, Marchetto S, Lecine P, et al. A role for Erbin in the regulation of Nod2-dependent NF-kappaB signaling. J Biol Chem. 2005;280:40301-9 pubmed
    ..We performed a biochemical screen to discover potential regulators of Nod2 and identified Erbin, a protein involved in cell polarity, receptor localization, and regulation of the mitogen-activated protein ..
  15. Tao Y, Shen C, Luo S, Traoré W, Marchetto S, Santoni M, et al. Role of Erbin in ErbB2-dependent breast tumor growth. Proc Natl Acad Sci U S A. 2014;111:E4429-38 pubmed publisher
    ..We report here that Erbin, an ErbB2-interacting protein that was thought to act as an antitumor factor, is specifically expressed in mammary ..
  16. Jaulin Bastard F, Arsanto J, Le Bivic A, Navarro C, Vely F, Saito H, et al. Interaction between Erbin and a Catenin-related protein in epithelial cells. J Biol Chem. 2002;277:2869-75 pubmed
    ..We previously described Erbin as a mammalian LET-413 homologue interacting with ERBB2/HER2, an epidermal growth factor receptor family member...
  17. Pan P, Dobrowsky R. Differential expression of neuregulin-1 isoforms and downregulation of erbin are associated with Erb B2 receptor activation in diabetic peripheral neuropathy. Acta Neuropathol Commun. 2013;1:39 pubmed publisher
    ..Alternatively, Erb B2 activity can be negatively regulated by association with the Erb B2-interacting protein, erbin. Since the effect of diabetes on the expression of NRG1 isoforms and erbin in peripheral nerve are unknown, the ..
  18. Xie C, Wei D, Zhao L, Marchetto S, Mei L, Borg J, et al. Erbin is a novel substrate of the Sag-βTrCP E3 ligase that regulates KrasG12D-induced skin tumorigenesis. J Cell Biol. 2015;209:721-37 pubmed publisher
    ..Simultaneous one-allele deletion of the Erbin-encoding gene Erbb2ip partially rescued the phenotypes. Finally, we characterized Erbin as a novel substrate of SAG-βTrCP E3 ligase...
  19. Dai P, Xiong W, Mei L. Erbin inhibits RAF activation by disrupting the sur-8-Ras-Raf complex. J Biol Chem. 2006;281:927-33 pubmed
    b>Erbin is a member of the LAP (leucine-rich repeat (LRR) and PDZ domain) family. It inhibits Ras-mediated activation of ERK in response to growth factors...