Erbb4

Summary

Gene Symbol: Erbb4
Description: erb-b2 receptor tyrosine kinase 4
Alias: Her4, c-erbB-4, receptor tyrosine-protein kinase erbB-4, avian erythroblastosis oncogene B 4, proto-oncogene-like protein c-ErbB-4, v-erb-a erythroblastic leukemia viral oncogene homolog 4
Species: mouse
Products:     Erbb4

Top Publications

  1. Long W, Wagner K, Lloyd K, Binart N, Shillingford J, Hennighausen L, et al. Impaired differentiation and lactational failure of Erbb4-deficient mammary glands identify ERBB4 as an obligate mediator of STAT5. Development. 2003;130:5257-68 pubmed
    ..Here, we show that mice with Cre-lox mediated deletions of both Erbb4 alleles within the developing mammary gland (Erbb4(Flox/Flox)Wap-Cre) fail to accumulate lobuloalveoli or ..
  2. Gassmann M, Casagranda F, Orioli D, Simon H, Lai C, Klein R, et al. Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor. Nature. 1995;378:390-4 pubmed
    Various in vitro studies have suggested that ErbB4 (HER4) is a receptor for the neuregulins, a family of closely related proteins implicated as regulators of neural and muscle development, and of the differentiation and oncogenic ..
  3. Fazzari P, Paternain A, Valiente M, Pla R, Lujan R, Lloyd K, et al. Control of cortical GABA circuitry development by Nrg1 and ErbB4 signalling. Nature. 2010;464:1376-80 pubmed publisher
    ..Several independent studies have identified neuregulin 1 (NRG1) and its receptor ERBB4 as important risk genes for schizophrenia, although their precise role in the disease process remains unknown...
  4. Wen L, Lu Y, Zhu X, Li X, Woo R, Chen Y, et al. Neuregulin 1 regulates pyramidal neuron activity via ErbB4 in parvalbumin-positive interneurons. Proc Natl Acad Sci U S A. 2010;107:1211-6 pubmed publisher
    ..Ablation of the NRG1 receptor ErbB4 in parvalbumin (PV)-positive interneurons prevented NRG1 from stimulating GABA release and from inhibiting ..
  5. Muraoka Cook R, Sandahl M, Strunk K, Miraglia L, Husted C, Hunter D, et al. ErbB4 splice variants Cyt1 and Cyt2 differ by 16 amino acids and exert opposing effects on the mammary epithelium in vivo. Mol Cell Biol. 2009;29:4935-48 pubmed publisher
    Data concerning the prognostic value of ErbB4 in breast cancer and effects on cell growth have varied in published reports, perhaps due to the unknown signaling consequences of expression of the intracellular proteolytic ErbB4 s80(HER4) ..
  6. Meyer D, Yamaai T, Garratt A, Riethmacher Sonnenberg E, Kane D, Theill L, et al. Isoform-specific expression and function of neuregulin. Development. 1997;124:3575-86 pubmed
    ..The complexity of neuregulin functions in development is therefore due to independent roles played by distinct isoforms. ..
  7. Chen S, Velardez M, Warot X, Yu Z, Miller S, Cros D, et al. Neuregulin 1-erbB signaling is necessary for normal myelination and sensory function. J Neurosci. 2006;26:3079-86 pubmed
    ..These results suggest that disruption of the NRG1-erbB signaling pathway could contribute to the pathogenesis of peripheral neuropathies with hypomyelination and neuropathic pain. ..
  8. Ting A, Chen Y, Wen L, Yin D, Shen C, Tao Y, et al. Neuregulin 1 promotes excitatory synapse development and function in GABAergic interneurons. J Neurosci. 2011;31:15-25 pubmed publisher
    Neuregulin 1 (NRG1) and its receptor ErbB4 are both susceptibility genes of schizophrenia. However, little is known about the underlying mechanisms of their malfunction...
  9. Vullhorst D, Neddens J, Karavanova I, Tricoire L, Petralia R, McBain C, et al. Selective expression of ErbB4 in interneurons, but not pyramidal cells, of the rodent hippocampus. J Neurosci. 2009;29:12255-64 pubmed publisher
    NRG1 and ERBB4 have emerged as some of the most reproducible schizophrenia risk genes...

More Information

Publications78

  1. Bersell K, Arab S, Haring B, Kuhn B. Neuregulin1/ErbB4 signaling induces cardiomyocyte proliferation and repair of heart injury. Cell. 2009;138:257-70 pubmed publisher
    ..for controlling this process that involves the growth factor neuregulin1 (NRG1) and its tyrosine kinase receptor, ErbB4. NRG1 induces mononucleated, but not binucleated, cardiomyocytes to divide...
  2. Purevdorj E, Zscheppang K, Hoymann H, Braun A, von Mayersbach D, Brinkhaus M, et al. ErbB4 deletion leads to changes in lung function and structure similar to bronchopulmonary dysplasia. Am J Physiol Lung Cell Mol Physiol. 2008;294:L516-22 pubmed publisher
    Neuregulin is an important growth factor in fetal surfactant synthesis, and downregulation of its receptor, ErbB4, impairs fetal surfactant synthesis...
  3. Bjarnadottir M, Misner D, Haverfield Gross S, Bruun S, Helgason V, Stefansson H, et al. Neuregulin1 (NRG1) signaling through Fyn modulates NMDA receptor phosphorylation: differential synaptic function in NRG1+/- knock-outs compared with wild-type mice. J Neurosci. 2007;27:4519-29 pubmed
    ..We now present evidence that ErbB4 (v-erb-a erythroblastic leukemia viral oncogene homolog 4), the tyrosine kinase receptor for NRG1 in hippocampal ..
  4. Garcia Rivello H, Taranda J, Said M, Cabeza Meckert P, Vila Petroff M, Scaglione J, et al. Dilated cardiomyopathy in Erb-b4-deficient ventricular muscle. Am J Physiol Heart Circ Physiol. 2005;289:H1153-60 pubmed
    ..This cardiac dysfunction may account for premature death in adult erb-b4-knockout mice. This study establishes a critical role for Erb-b4 in the maintenance of normal postnatal cardiac structure and function. ..
  5. Anton E, Ghashghaei H, Weber J, McCann C, Fischer T, Cheung I, et al. Receptor tyrosine kinase ErbB4 modulates neuroblast migration and placement in the adult forebrain. Nat Neurosci. 2004;7:1319-28 pubmed
    ..Here, we show that the receptor tyrosine kinase ErbB4 is expressed prominently by the neuroblasts present in the subventricular zone and the rostral migratory stream...
  6. Flames N, Long J, Garratt A, Fischer T, Gassmann M, Birchmeier C, et al. Short- and long-range attraction of cortical GABAergic interneurons by neuregulin-1. Neuron. 2004;44:251-61 pubmed
    ..that migrating interneurons follow toward the cortex, whereas a population of the migrating interneurons express ErbB4, a receptor for Neuregulin-1...
  7. Li H, Chou S, Hamasaki T, Perez Garcia C, O Leary D. Neuregulin repellent signaling via ErbB4 restricts GABAergic interneurons to migratory paths from ganglionic eminence to cortical destinations. Neural Dev. 2012;7:10 pubmed publisher
    ..Because most, if not all, migrating MGE-derived INs express the neuregulin (NRG) receptor, ErbB4, we investigated influences of Nrg1 isoforms and Nrg3 on IN migration through ventral telencephalon (vTel) and ..
  8. Carraway K. Involvement of the neuregulins and their receptors in cardiac and neural development. Bioessays. 1996;18:263-6 pubmed
    ..system in mice by disrupting the genes encoding the neuregulin ligand(1) and two of its receptors, ErbB2(2) and ErbB4(3)...
  9. Barros C, Calabrese B, Chamero P, Roberts A, Korzus E, Lloyd K, et al. Impaired maturation of dendritic spines without disorganization of cortical cell layers in mice lacking NRG1/ErbB signaling in the central nervous system. Proc Natl Acad Sci U S A. 2009;106:4507-12 pubmed publisher
    ..We conclude that ErbB2/B4-mediated NRG1 signaling modulates dendritic spine maturation, and that defects at glutamatergic synapses likely contribute to the behavioral abnormalities in ErbB2/B4-deficient mice. ..
  10. Aqeilan R, Donati V, Palamarchuk A, Trapasso F, Kaou M, Pekarsky Y, et al. WW domain-containing proteins, WWOX and YAP, compete for interaction with ErbB-4 and modulate its transcriptional function. Cancer Res. 2005;65:6764-72 pubmed
    ..In summary, our data indicate that WWOX antagonizes the function of YAP by competing for interaction with ErbB-4 and other targets and thus affect its transcriptional activity. ..
  11. Jackson Fisher A, Bellinger G, Shum E, Duong J, Perkins A, Gassmann M, et al. Formation of Neu/ErbB2-induced mammary tumors is unaffected by loss of ErbB4. Oncogene. 2006;25:5664-72 pubmed
    ..growth factor receptor, ErbB2 and ErbB3 are positively associated with various cancers, clinical studies of ErbB4 in breast cancer are contradictory...
  12. Kramer R, Bucay N, Kane D, Martin L, Tarpley J, Theill L. Neuregulins with an Ig-like domain are essential for mouse myocardial and neuronal development. Proc Natl Acad Sci U S A. 1996;93:4833-8 pubmed
    ..The trigeminal ganglion is reduced in size and lacks projections toward the brain stem and mandible. We conclude that IgL-domain-containing neuregulins play a major role in cardiac and neuronal development. ..
  13. Li K, Lu Y, Xu Z, Zhang J, Zhu J, Zhang J, et al. Neuregulin 1 regulates excitability of fast-spiking neurons through Kv1.1 and acts in epilepsy. Nat Neurosci. 2011;15:267-73 pubmed publisher
    ..b>ErbB4, a key Neuregulin 1 (NRG1) receptor, is mainly expressed in this type of interneurons, and recent studies suggest ..
  14. Gajendran N, Kapfhammer J, Lain E, Canepari M, Vogt K, Wisden W, et al. Neuregulin signaling is dispensable for NMDA- and GABA(A)-receptor expression in the cerebellum in vivo. J Neurosci. 2009;29:2404-13 pubmed publisher
    ..To this end, we used the Cre/loxP system to genetically ablate the NRG receptors ErbB2 and ErbB4 selectively in these cells, thus eliminating all NRG-mediated signaling to them...
  15. Krivosheya D, Tapia L, Levinson J, Huang K, Kang Y, Hines R, et al. ErbB4-neuregulin signaling modulates synapse development and dendritic arborization through distinct mechanisms. J Biol Chem. 2008;283:32944-56 pubmed publisher
    Perturbations in neuregulin-1 (NRG1)/ErbB4 function have been associated with schizophrenia...
  16. Feng S, Muraoka Cook R, Hunter D, Sandahl M, Caskey L, Miyazawa K, et al. The E3 ubiquitin ligase WWP1 selectively targets HER4 and its proteolytically derived signaling isoforms for degradation. Mol Cell Biol. 2009;29:892-906 pubmed publisher
    In general, epidermal growth factor receptor family members stimulate cell proliferation. In contrast, at least one HER4 isoform, JM-a/Cyt1, inhibits cell growth after undergoing a two-step proteolytic cleavage that first produces a ..
  17. Wolpowitz D, Mason T, Dietrich P, Mendelsohn M, Talmage D, Role L. Cysteine-rich domain isoforms of the neuregulin-1 gene are required for maintenance of peripheral synapses. Neuron. 2000;25:79-91 pubmed
  18. Jones F, Welte T, Fu X, Stern D. ErbB4 signaling in the mammary gland is required for lobuloalveolar development and Stat5 activation during lactation. J Cell Biol. 1999;147:77-88 pubmed
    ..Earlier work suggested that one of these receptors, ErbB4, is coupled to unique responses in this tissue...
  19. Frey M, Edelblum K, Mullane M, Liang D, Polk D. The ErbB4 growth factor receptor is required for colon epithelial cell survival in the presence of TNF. Gastroenterology. 2009;136:217-26 pubmed publisher
    The ErbB4 receptor tyrosine kinase regulates cell growth, survival, and differentiation in several tissues, but its role in the gastrointestinal tract has not been reported...
  20. Fox I, Kornblum H. Developmental profile of ErbB receptors in murine central nervous system: implications for functional interactions. J Neurosci Res. 2005;79:584-97 pubmed
    The ErbB family, ErbB1 (also known as the epidermal growth factor receptor EGFR), ErbB2, ErbB3, and ErbB4 comprise a group of receptor tyrosine kinases that interact with ligands from the epidermal growth factor (EGF) superfamily, ..
  21. Elenius K, Corfas G, Paul S, Choi C, Rio C, Plowman G, et al. A novel juxtamembrane domain isoform of HER4/ErbB4. Isoform-specific tissue distribution and differential processing in response to phorbol ester. J Biol Chem. 1997;272:26761-8 pubmed
    Human epidermal growth factor receptor 4 (HER4) is a member of the epidermal growth factor (EGF) receptor subfamily of receptor tyrosine kinases that is activated by neuregulins (NRG), betacellulin (BTC), and heparin-binding EGF-like ..
  22. Meyer D, Birchmeier C. Multiple essential functions of neuregulin in development. Nature. 1995;378:386-90 pubmed
    ..Neuregulin can bind directly to erbB3 and erbB4 and receptor heterodimerization allows neuregulin-dependent activation of erbB2 (refs 1, 2, 5)...
  23. Cheng Q, Tikhomirov O, Zhou W, Carpenter G. Ectodomain cleavage of ErbB-4: characterization of the cleavage site and m80 fragment. J Biol Chem. 2003;278:38421-7 pubmed
    ..When the m80 ErbB-4 fragment is generated by cell treatment with heregulin or 12-O-tetradecanoylphorbol-13-acetate, the fragment associates with intact ErbB-2. However, this fragment does not associate with the intact ErbB-4 molecule. ..
  24. Bao J, Wolpowitz D, Role L, Talmage D. Back signaling by the Nrg-1 intracellular domain. J Cell Biol. 2003;161:1133-41 pubmed
    ..Thus, regulated proteolytic processing of Nrg-1 results in retrograde signaling that appears to mediate contact and activity-dependent survival of Nrg-1-expressing neurons. ..
  25. Tidcombe H, Jackson Fisher A, Mathers K, Stern D, Gassmann M, Golding J. Neural and mammary gland defects in ErbB4 knockout mice genetically rescued from embryonic lethality. Proc Natl Acad Sci U S A. 2003;100:8281-6 pubmed
    Mice lacking the epidermal growth factor receptor family member ErbB4 exhibit defects in cranial neural crest cell migration but die by embryonic day 11 because of defective heart development...
  26. Veikkolainen V, Naillat F, Railo A, Chi L, Manninen A, Hohenstein P, et al. ErbB4 modulates tubular cell polarity and lumen diameter during kidney development. J Am Soc Nephrol. 2012;23:112-22 pubmed publisher
    b>ErbB4 receptor tyrosine kinase contributes to the development of the heart, the central nervous system, and the lactating mammary gland, but whether it has a role in the development of the kidney epithelium is unknown...
  27. Sardi S, Murtie J, Koirala S, Patten B, Corfas G. Presenilin-dependent ErbB4 nuclear signaling regulates the timing of astrogenesis in the developing brain. Cell. 2006;127:185-97 pubmed
    ..Upon neuregulin-induced activation and presenilin-dependent cleavage of ErbB4, the receptor's intracellular domain forms a complex with TAB2 and the corepressor N-CoR...
  28. Golub M, Germann S, Lloyd K. Behavioral characteristics of a nervous system-specific erbB4 knock-out mouse. Behav Brain Res. 2004;153:159-70 pubmed
    b>ErbB4 is an important brain receptor for the neuregulin1 growth factor. A conditional knock-out mouse was developed lacking both alleles of the erbB4 gene in neurons/glia, and one allele in other cells...
  29. Stefansson H, Sigurdsson E, Steinthorsdottir V, Bjornsdottir S, Sigmundsson T, Ghosh S, et al. Neuregulin 1 and susceptibility to schizophrenia. Am J Hum Genet. 2002;71:877-92 pubmed
    ..Mutant mice heterozygous for either NRG1 or its receptor, ErbB4, show a behavioral phenotype that overlaps with mouse models for schizophrenia...
  30. Lemmens K, Doggen K, De Keulenaer G. Role of neuregulin-1/ErbB signaling in cardiovascular physiology and disease: implications for therapy of heart failure. Circulation. 2007;116:954-60 pubmed
    ..On the other hand, pharmacological activation of ErbB signaling is likely an unrecognized and beneficial effect of currently used drugs in heart failure and a promising therapeutic approach to prevent or reverse myocardial dysfunction. ..
  31. Lopez Bendito G, Cautinat A, Sanchez J, Bielle F, Flames N, Garratt A, et al. Tangential neuronal migration controls axon guidance: a role for neuregulin-1 in thalamocortical axon navigation. Cell. 2006;125:127-42 pubmed
    ..These results show that neuronal tangential migration constitutes a novel mechanism to control the timely arrangement of guidance cues required for axonal tract formation in the mammalian brain. ..
  32. Escher P, Lacazette E, Courtet M, Blindenbacher A, Landmann L, Bezakova G, et al. Synapses form in skeletal muscles lacking neuregulin receptors. Science. 2005;308:1920-3 pubmed
    ..Here, we demonstrate that NMJs can form in the absence of the NRG receptors ErbB2 and ErbB4 in mouse muscle. Postsynaptic differentiation is, however, induced by Agrin...
  33. Lynch C, Vargo Gogola T, Martin M, Fingleton B, Crawford H, Matrisian L. Matrix metalloproteinase 7 mediates mammary epithelial cell tumorigenesis through the ErbB4 receptor. Cancer Res. 2007;67:6760-7 pubmed
    ..Subsequent investigation showed that MMP7 (a) up-regulated ErbB4 receptor levels, (b) solubilized the ErbB4 receptor cognate ligand heparin-bound epidermal growth factor, and (c) ..
  34. Shekhar A, Lin X, Liu F, Zhang J, Mo H, Bastarache L, et al. Transcription factor ETV1 is essential for rapid conduction in the heart. J Clin Invest. 2016;126:4444-4459 pubmed publisher
    ..Together, these results identify ETV1 as a critical factor in determining fast conduction physiology in the heart. ..
  35. Wang K, Chang F, Chiang C, Chen K, Kuo M. Temporal and spatial expression of erbB4 in ectodermal and mesenchymal cells during primary palatogenesis in noncleft and cleft strains of mice. J Oral Pathol Med. 1998;27:141-6 pubmed
    ..Binding of a ligand to erbB4 has been shown to stimulate the receptor's protein kinase activity, which subsequently stimulates a signal-..
  36. Ghashghaei H, Weber J, Pevny L, Schmid R, Schwab M, Lloyd K, et al. The role of neuregulin-ErbB4 interactions on the proliferation and organization of cells in the subventricular zone. Proc Natl Acad Sci U S A. 2006;103:1930-5 pubmed
    ..Here, we investigate the role of neuregulins (NRGs) in this process and show that a NRG receptor, ErbB4, is primarily expressed by polysialylated neural cell adhesion molecule immature neuroblasts but is also detected ..
  37. Howard B, Panchal H, McCarthy A, Ashworth A. Identification of the scaramanga gene implicates Neuregulin3 in mammary gland specification. Genes Dev. 2005;19:2078-90 pubmed
    ..Localized expression of Nrg3 and its receptor, Erbb4, in the presumptive mammary region around the future bud site prior to morphological appearance of buds and the ..
  38. Lee D, Chen J, Lundy D, Liu C, Hwang S, Pabon L, et al. Defined MicroRNAs Induce Aspects of Maturation in Mouse and Human Embryonic-Stem-Cell-Derived Cardiomyocytes. Cell Rep. 2015;12:1960-7 pubmed publisher
    ..A luciferase assay demonstrated that all four miRNAs target ErbB4, and siRNA knockdown of ErbB4 partially recapitulated the effects of miR-combo...
  39. Ying G, Wu S, Hou R, Huang W, Capecchi M, Wu Q. The protocadherin gene Celsr3 is required for interneuron migration in the mouse forebrain. Mol Cell Biol. 2009;29:3045-61 pubmed publisher
    ..Finally, we found that expression patterns of NRG1 (neuregulin-1) and its receptor ErbB4, which are essential for interneuron migration, are changed in Celsr3 mutants...
  40. Löf Öhlin Z, Nyeng P, Bechard M, Hess K, Bankaitis E, Greiner T, et al. EGFR signalling controls cellular fate and pancreatic organogenesis by regulating apicobasal polarity. Nat Cell Biol. 2017;19:1313-1325 pubmed publisher
    ..We provide insight into how ligand-specific EGFR signalling coordinates epithelial morphogenesis and cell differentiation via apical polarity dynamics. ..
  41. White R, Siegel S. Cellular and circuit models of increased resting-state network gamma activity in schizophrenia. Neuroscience. 2016;321:66-76 pubmed publisher
    ..We address how modeling this aspect of the illness in animals may help treatment development as well as providing insights into the etiology of SCZ. ..
  42. Zhang H, Zhang L, Zhou D, He X, Wang D, Pan H, et al. Ablating ErbB4 in PV neurons attenuates synaptic and cognitive deficits in an animal model of Alzheimer's disease. Neurobiol Dis. 2017;106:171-180 pubmed publisher
    ..In the present study, we found that A? interacted with ErbB4, a member of the receptor tyrosine kinase family and mainly expressed in GABAergic interneurons...
  43. Dayton T, Gocheva V, Miller K, Israelsen W, Bhutkar A, Clish C, et al. Germline loss of PKM2 promotes metabolic distress and hepatocellular carcinoma. Genes Dev. 2016;30:1020-33 pubmed publisher
    ..Therefore, in addition to its role in cancer metabolism, PKM2 plays a role in controlling systemic metabolic homeostasis and inflammation, thereby preventing HCC by a non-cell-autonomous mechanism. ..
  44. Sandau U, Mungenast A, Alderman Z, Sardi S, Fogel A, Taylor B, et al. SynCAM1, a synaptic adhesion molecule, is expressed in astrocytes and contributes to erbB4 receptor-mediated control of female sexual development. Endocrinology. 2011;152:2364-76 pubmed publisher
    ..requires erythroblastosis B (erbB)4 signaling in hypothalamic astrocytes; however, the mechanisms by which erbB4 contributes to this process are incompletely understood...
  45. Lu Y, Sun X, Hou F, Bi L, Yin D, Liu F, et al. Maintenance of GABAergic activity by neuregulin 1-ErbB4 in amygdala for fear memory. Neuron. 2014;84:835-46 pubmed publisher
    ..We provide evidence that neuregulin 1 (NRG1) and its receptor ErbB4 tyrosine kinase are critical for maintaining GABAergic activity in amygdala...
  46. Mitchell R, Janssen M, Karavanova I, Vullhorst D, Furth K, Makusky A, et al. ErbB4 reduces synaptic GABAA currents independent of its receptor tyrosine kinase activity. Proc Natl Acad Sci U S A. 2013;110:19603-8 pubmed publisher
    b>ErbB4 signaling in the central nervous system is implicated in neuropsychiatric disorders and epilepsy. In cortical tissue, ErbB4 associates with excitatory synapses located on inhibitory interneurons...
  47. Rokicki J, Das P, Giltnane J, Wansbury O, Rimm D, Howard B, et al. The ERalpha coactivator, HER4/4ICD, regulates progesterone receptor expression in normal and malignant breast epithelium. Mol Cancer. 2010;9:150 pubmed publisher
    The HER4 intracellular domain (4ICD) is a potent estrogen receptor (ERalpha) coactivator with activities in breast cancer and the developing mammary gland that appear to overlap with progesterone receptor (PgR)...
  48. Prevot V, Lomniczi A, Corfas G, Ojeda S. erbB-1 and erbB-4 receptors act in concert to facilitate female sexual development and mature reproductive function. Endocrinology. 2005;146:1465-72 pubmed
    ..Thus, a coordinated involvement of erbB-1 and erbB-4 signaling systems is required for the normalcy of sexual development and the maintenance of mature female reproductive function. ..
  49. Brown N, Deb K, Paria B, Das S, Reese J. Embryo-uterine interactions via the neuregulin family of growth factors during implantation in the mouse. Biol Reprod. 2004;71:2003-11 pubmed
  50. Moscoso L, Chu G, Gautam M, Noakes P, Merlie J, Sanes J. Synapse-associated expression of an acetylcholine receptor-inducing protein, ARIA/heregulin, and its putative receptors, ErbB2 and ErbB3, in developing mammalian muscle. Dev Biol. 1995;172:158-69 pubmed
    ..ARIA-responsive myotubes expressed both erbB2 and erbB3, but little EGFR/erbB1 or erbB4. In adults, erbB2 and erbB3 were localized to the postsynaptic membrane...
  51. Wu G, Liu X, Lu N, Liu Q, Tian Y, Ye W, et al. Endothelial ErbB4 deficit induces alterations in exploratory behavior and brain energy metabolism in mice. CNS Neurosci Ther. 2017;23:510-517 pubmed publisher
    The receptor tyrosine kinase ErbB4 is present throughout the primate brain and has a distinct functional profile. In this study, we investigate the potential role of endothelial ErbB4 receptor signaling in the brain...
  52. Bartolini G, Sánchez Alcañiz J, Osório C, Valiente M, García Frigola C, Marín O. Neuregulin 3 Mediates Cortical Plate Invasion and Laminar Allocation of GABAergic Interneurons. Cell Rep. 2017;18:1157-1170 pubmed publisher
    ..migration of interneurons into the cortical plate in a process that is dependent on the tyrosine kinase receptor ErbB4. Perturbation of Nrg3 signaling in conditional mutants leads to abnormal lamination of cortical interneurons...
  53. Yasui T, Masaki T, Arita Y, Ishibashi T, Inagaki T, Okazawa M, et al. Molecular Characterization of Striated Muscle-Specific Gab1 Isoform as a Critical Signal Transducer for Neuregulin-1/ErbB Signaling in Cardiomyocytes. PLoS ONE. 2016;11:e0166710 pubmed publisher
    ..Taken together, these findings suggest that the striated muscle-specific high-MW isoform of Gab1 has a crucial role for NRG-1/ErbB signaling in cardiomyocytes. ..
  54. Longart M, Chatani Hinze M, Gonzalez C, Vullhorst D, Buonanno A. Regulation of ErbB-4 endocytosis by neuregulin in GABAergic hippocampal interneurons. Brain Res Bull. 2007;73:210-9 pubmed
    ..These results enhance our understanding of the regulation of ErbB-4--mediated signaling at glutamatergic synapses. ..
  55. Pitcher G, Beggs S, Woo R, Mei L, Salter M. ErbB4 is a suppressor of long-term potentiation in the adult hippocampus. Neuroreport. 2008;19:139-43 pubmed publisher
    b>ErbB4 has emerged as a leading susceptibility gene for schizophrenia but the function of the ErbB4 receptor in the adult brain is unknown...
  56. Wrobel C, Mutch C, Swaminathan S, Taketo M, Chenn A. Persistent expression of stabilized beta-catenin delays maturation of radial glial cells into intermediate progenitors. Dev Biol. 2007;309:285-97 pubmed
    ..Furthermore, transgenic cortical cells fail to either upregulate ErbB4 or develop a mitogenic response to epidermal growth factor, changes that normally accompany the acquisition of an ..
  57. Cooper M, Koleske A. Ablation of ErbB4 from excitatory neurons leads to reduced dendritic spine density in mouse prefrontal cortex. J Comp Neurol. 2014;522:3351-62 pubmed publisher
    ..b>ErbB4, a member of the EGF family of receptor tyrosine kinases, is genetically associated with schizophrenia, suggesting ..
  58. Muraoka Cook R, Sandahl M, Husted C, Hunter D, Miraglia L, Feng S, et al. The intracellular domain of ErbB4 induces differentiation of mammary epithelial cells. Mol Biol Cell. 2006;17:4118-29 pubmed
    Differentiation of mammary epithelium in vivo requires signaling through prolactin- and ErbB4/HER4-dependent mechanisms; how these pathways intersect is unknown...
  59. Hoeing K, Zscheppang K, Mujahid S, Murray S, Volpe M, Dammann C, et al. Presenilin-1 processing of ErbB4 in fetal type II cells is necessary for control of fetal lung maturation. Biochim Biophys Acta. 2011;1813:480-91 pubmed publisher
    ..Little is known about specific mechanisms of signal transduction controlling type II cell maturation. The ErbB4 receptor and its ligand neuregulin (NRG) are critical for lung development...
  60. Zscheppang K, Dork T, Schmiedl A, Jones F, Dammann C. Neuregulin receptor ErbB4 functions as a transcriptional cofactor for the expression of surfactant protein B in the fetal lung. Am J Respir Cell Mol Biol. 2011;45:761-7 pubmed publisher
    ..Neuregulin (NRG) and its transmembrane receptor ErbB4 positively regulate the onset of fetal surfactant synthesis...
  61. Shu T, Li Y, Keller A, Richards L. The glial sling is a migratory population of developing neurons. Development. 2003;130:2929-37 pubmed
    ..These data indicate that the sling may be a source of, or migratory pathway for, developing neurons in the rostral forebrain, suggesting additional functions for the sling independent of callosal axon guidance. ..
  62. Geng F, Zhang J, Wu J, Zou W, Liang Z, Bi L, et al. Neuregulin 1-ErbB4 signaling in the bed nucleus of the stria terminalis regulates anxiety-like behavior. Neuroscience. 2016;329:182-92 pubmed publisher
    ..Here, we showed that blocking neuregulin 1 (NRG1)-ErbB4 signaling in the BNST of mice, by either neutralizing endogenous NRG1 with ecto-Erbb4 or antagonizing the ErbB4 ..
  63. Golding J, Trainor P, Krumlauf R, Gassmann M. Defects in pathfinding by cranial neural crest cells in mice lacking the neuregulin receptor ErbB4. Nat Cell Biol. 2000;2:103-9 pubmed
    Mouse embryos with a loss-of-function mutation in the gene encoding the receptor tyrosine kinase ErbB4 exhibit misprojections of cranial sensory ganglion afferent axons...
  64. Fisahn A, Neddens J, Yan L, Buonanno A. Neuregulin-1 modulates hippocampal gamma oscillations: implications for schizophrenia. Cereb Cortex. 2009;19:612-8 pubmed publisher
    Alterations in gamma-frequency oscillations are implicated in psychiatric disorders, and polymorphisms in NRG-1 and ERBB4, genes encoding Neuregulin-1 (NRG-1) and one of its receptors, designated ErbB4, are associated with schizophrenia...
  65. Zhang D, Sliwkowski M, Mark M, Frantz G, Akita R, Sun Y, et al. Neuregulin-3 (NRG3): a novel neural tissue-enriched protein that binds and activates ErbB4. Proc Natl Acad Sci U S A. 1997;94:9562-7 pubmed
    ..The biological effects of NRG1 are mediated by receptor tyrosine kinases ErbB2, ErbB3, and ErbB4. However, genetic studies have suggested that the activity of ErbB4 may also be regulated in the central nervous ..
  66. Mysliwiec M, Bresnick E, Lee Y. Endothelial Jarid2/Jumonji is required for normal cardiac development and proper Notch1 expression. J Biol Chem. 2011;286:17193-204 pubmed publisher
    ..The identification of Jarid2 as a potential regulator of Notch1 signaling has broad implications for many cellular processes including development, stem cell maintenance, and tumor formation. ..
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    ..Immunohistochemical analysis of ERBB family receptors, ERBB2, ERBB3, and ERBB4, showed similar expression between Egfr wildtype and null placentas indicating that Egfr null trophoblast do not ..
  68. Lee H, Khan S, Khaliqdina S, Altintas M, Grahammer F, Zhao J, et al. Absence of miR-146a in Podocytes Increases Risk of Diabetic Glomerulopathy via Up-regulation of ErbB4 and Notch-1. J Biol Chem. 2017;292:732-747 pubmed publisher
    ..The miR-146a targets, Notch-1 and ErbB4, were also significantly up-regulated in the glomeruli of diabetic patients and mice, suggesting induction of the ..
  69. Geng H, Zhang J, Yang J, Li Y, Wang N, Ye M, et al. Erbb4 Deletion from Medium Spiny Neurons of the Nucleus Accumbens Core Induces Schizophrenia-Like Behaviors via Elevated GABAA Receptor ?1 Subunit Expression. J Neurosci. 2017;37:7450-7464 pubmed publisher
    ..We found that a deficiency in Erbb4, a schizophrenia risk gene, in MSNs of the nucleus accumbens (NAc) core, but not the dorsomedial striatum, ..