Erbb2

Summary

Gene Symbol: Erbb2
Description: erb-b2 receptor tyrosine kinase 2
Alias: Erbb-2, HER-2, HER2, Neu, c-erbB2, c-neu, l11Jus8, mKIAA3023, receptor tyrosine-protein kinase erbB-2, Neu oncogene, avian erythroblastosis oncogene B 2, c-erbB-2, p185erbB2, proto-oncogene NEU, proto-oncogene c-ErbB-2, v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog
Species: mouse
Products:     Erbb2

Top Publications

  1. Threadgill D, Dlugosz A, Hansen L, Tennenbaum T, Lichti U, Yee D, et al. Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotype. Science. 1995;269:230-4 pubmed
    ..The multiple abnormalities associated with EGFR deficiency indicate that the receptor is involved in a wide range of cellular activities. ..
  2. Crone S, Negro A, Trumpp A, Giovannini M, Lee K. Colonic epithelial expression of ErbB2 is required for postnatal maintenance of the enteric nervous system. Neuron. 2003;37:29-40 pubmed
    We utilized the Cre-LoxP system to establish erbB2 conditional mutant mice in order to investigate the role of erbB2 in postnatal development of the enteric nervous system...
  3. Bu W, Zhang X, Dai H, Huang S, Li Y. Mammary cells with active Wnt signaling resist ErbB2-induced tumorigenesis. PLoS ONE. 2013;8:e78720 pubmed publisher
    ..Surprisingly, we found that RCAS-mediated delivery of cDNA encoding a constitutively activated version of ErbB2 (HER2/Neu) into the small number of TVA+ mammary epithelial cells in TOP-tva mice failed to induce tumor, while ..
  4. Woldeyesus M, Britsch S, Riethmacher D, Xu L, Sonnenberg Riethmacher E, Abou Rebyeh F, et al. Peripheral nervous system defects in erbB2 mutants following genetic rescue of heart development. Genes Dev. 1999;13:2538-48 pubmed
    The ErbB2 tyrosine kinase functions as coreceptor for the neuregulin receptors ErbB3 and ErbB4 and can participate in signaling of EGF receptor (ErbB1), interleukin receptor gp130, and G-protein coupled receptors...
  5. Houshmandi S, Emnett R, Giovannini M, Gutmann D. The neurofibromatosis 2 protein, merlin, regulates glial cell growth in an ErbB2- and Src-dependent manner. Mol Cell Biol. 2009;29:1472-86 pubmed publisher
    ..Next, we demonstrate that Src activation results from merlin regulation of ErbB2 activation and that genetic or pharmacologic ErbB2 inhibition reduces Nf2(-/-) glial cell Src/Src effector ..
  6. Muller W, Arteaga C, Muthuswamy S, Siegel P, Webster M, Cardiff R, et al. Synergistic interaction of the Neu proto-oncogene product and transforming growth factor alpha in the mammary epithelium of transgenic mice. Mol Cell Biol. 1996;16:5726-36 pubmed
    Transgenic mice expressing either the neu proto-oncogene or transforming growth factor (TGF-alpha) in the mammary epithelium develop spontaneous focal mammary tumors that occur after a long latency...
  7. Barbieri I, Quaglino E, Maritano D, Pannellini T, Riera L, Cavallo F, et al. Stat3 is required for anchorage-independent growth and metastasis but not for mammary tumor development downstream of the ErbB-2 oncogene. Mol Carcinog. 2010;49:114-20 pubmed publisher
    ..3 (Stat3) in mammary tumorigenesis downstream of ErbB-2, we generated mice expressing the activated rat ErbB-2 (neu) but lacking Stat3 in the mammary epithelium...
  8. Zhou X, Agazie Y. Molecular mechanism for SHP2 in promoting HER2-induced signaling and transformation. J Biol Chem. 2009;284:12226-34 pubmed publisher
    The Src homology phosphotyrosyl phosphatase 2 (SHP2) plays a positive role in HER2-induced signaling and transformation, but its mechanism of action is poorly understood...
  9. Bouchard L, Lamarre L, Tremblay P, Jolicoeur P. Stochastic appearance of mammary tumors in transgenic mice carrying the MMTV/c-neu oncogene. Cell. 1989;57:931-6 pubmed
    Transgenic mice carrying the activated c-neu oncogene under the control of the mouse mammary tumor virus (MMTV) long terminal repeat were produced...

More Information

Publications69

  1. Andrechek E, Hardy W, Girgis Gabardo A, Perry R, Butler R, Graham F, et al. ErbB2 is required for muscle spindle and myoblast cell survival. Mol Cell Biol. 2002;22:4714-22 pubmed
    Signaling mediated by ErbB2 is thought to play a critical role in numerous developmental processes...
  2. Ozcelik C, Erdmann B, Pilz B, Wettschureck N, Britsch S, Hubner N, et al. Conditional mutation of the ErbB2 (HER2) receptor in cardiomyocytes leads to dilated cardiomyopathy. Proc Natl Acad Sci U S A. 2002;99:8880-5 pubmed
    The ErbB2 (Her2) proto-oncogene encodes a receptor tyrosine kinase, which is frequently amplified and overexpressed in human tumors...
  3. Guertin A, Zhang D, Mak K, Alberta J, Kim H. Microanatomy of axon/glial signaling during Wallerian degeneration. J Neurosci. 2005;25:3478-87 pubmed
    ..We show a hitherto undetected rapid, but transient, activation of the receptor tyrosine kinase erbB2 in myelinating Schwann cells after sciatic nerve axotomy...
  4. Shneider N, Mentis G, Schustak J, O Donovan M. Functionally reduced sensorimotor connections form with normal specificity despite abnormal muscle spindle development: the role of spindle-derived neurotrophin 3. J Neurosci. 2009;29:4719-35 pubmed publisher
    ..in mice with abnormal spindle development caused by the conditional elimination of the neuregulin 1 receptor ErbB2 from muscle precursors...
  5. Xi C, Hu Y, Buckhaults P, Moskophidis D, Mivechi N. Heat shock factor Hsf1 cooperates with ErbB2 (Her2/Neu) protein to promote mammary tumorigenesis and metastasis. J Biol Chem. 2012;287:35646-57 pubmed publisher
    ErbB2/Neu oncogene is overexpressed in 25% of invasive/metastatic breast cancers. We have found that deletion of heat shock factor Hsf1 in mice overexpressing ErbB2/Neu significantly reduces mammary tumorigenesis and metastasis...
  6. Siegel P, Ryan E, Cardiff R, Muller W. Elevated expression of activated forms of Neu/ErbB-2 and ErbB-3 are involved in the induction of mammary tumors in transgenic mice: implications for human breast cancer. EMBO J. 1999;18:2149-64 pubmed
    To assess the importance of Neu activation during mammary tumorigenesis, altered receptors harboring in-frame deletions within the extracellular domain were expressed in transgenic mice...
  7. Cabodi S, Tinnirello A, Bisaro B, Tornillo G, del Pilar Camacho Leal M, Forni G, et al. p130Cas is an essential transducer element in ErbB2 transformation. FASEB J. 2010;24:3796-808 pubmed publisher
    The ErbB2 oncogene is often overexpressed in breast tumors and associated with poor clinical outcome. p130Cas represents a nodal scaffold protein regulating cell survival, migration, and proliferation in normal and pathological cells...
  8. Xiang B, Chatti K, Qiu H, Lakshmi B, Krasnitz A, Hicks J, et al. Brk is coamplified with ErbB2 to promote proliferation in breast cancer. Proc Natl Acad Sci U S A. 2008;105:12463-8 pubmed publisher
    Amplification of the receptor tyrosine kinase ErbB2 is frequently observed in breast cancer...
  9. Borg J, Marchetto S, Le Bivic A, Ollendorff V, Jaulin Bastard F, Saito H, et al. ERBIN: a basolateral PDZ protein that interacts with the mammalian ERBB2/HER2 receptor. Nat Cell Biol. 2000;2:407-14 pubmed
    ..We have identified a new PDZ protein we named ERBIN (ERBB2 interacting protein) that acts as an adaptor for the receptor ERBB2/HER2 in epithelia...
  10. Guy C, Webster M, Schaller M, Parsons T, Cardiff R, Muller W. Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease. Proc Natl Acad Sci U S A. 1992;89:10578-82 pubmed
    Overexpression and amplification of the neu (c-erbB2, ERBB2) protooncogene have been implicated in the development of aggressive human breast cancer...
  11. Chan R, Hardy W, Dankort D, Laing M, Muller W. Modulation of Erbb2 signaling during development: a threshold level of Erbb2 signaling is required for development. Development. 2004;131:5551-60 pubmed
    We have generated a series of Erbb2 cDNA knock-in animals to explore the role of signaling pathways coupled to Erbb2 during development...
  12. Leu M, Bellmunt E, Schwander M, Farinas I, Brenner H, Muller U. Erbb2 regulates neuromuscular synapse formation and is essential for muscle spindle development. Development. 2003;130:2291-301 pubmed
    ..To analyze the function of Erbb2 in this process, we have inactivated the Erbb2 gene in developing muscle fibers by Cre/Lox-mediated gene ablation...
  13. Feldner J, Brandt B. Cancer cell motility--on the road from c-erbB-2 receptor steered signaling to actin reorganization. Exp Cell Res. 2002;272:93-108 pubmed
    ..The complex picture of the mode of actin reorganization, which is involved in tumor cell migration, is slowly emerging from the mists of cellular signaling pathways, but this is still by no means a clear view. ..
  14. Lee K, Simon H, Chen H, Bates B, Hung M, Hauser C. Requirement for neuregulin receptor erbB2 in neural and cardiac development. Nature. 1995;378:394-8 pubmed
    The receptor erbB2/neu is a member of the epidermal growth factor receptor (EGFR or erbB) family that also includes erbB3 and erbB4...
  15. Schade B, Rao T, Dourdin N, Lesurf R, Hallett M, Cardiff R, et al. PTEN deficiency in a luminal ErbB-2 mouse model results in dramatic acceleration of mammary tumorigenesis and metastasis. J Biol Chem. 2009;284:19018-26 pubmed publisher
  16. Oh Y, Shin S, Lee Y, Kim E, Jun H. Betacellulin-induced beta cell proliferation and regeneration is mediated by activation of ErbB-1 and ErbB-2 receptors. PLoS ONE. 2011;6:e23894 pubmed publisher
    ..These results suggest that BTC exerts proliferative activity on beta cells through the activation of ErbB-1 and ErbB-2 receptors, which may increase IRS-2 expression, contributing to the regeneration of beta cells. ..
  17. Morris J, Maklad A, Hansen L, Feng F, Sorensen C, Lee K, et al. A disorganized innervation of the inner ear persists in the absence of ErbB2. Brain Res. 2006;1091:186-99 pubmed
    b>ErbB2 protein is essential for the development of Schwann cells and for the normal fiber growth and myelin formation of peripheral nerves...
  18. Jackson Fisher A, Bellinger G, Ramabhadran R, Morris J, Lee K, Stern D. ErbB2 is required for ductal morphogenesis of the mammary gland. Proc Natl Acad Sci U S A. 2004;101:17138-43 pubmed
    The ERBB2/HER2/NEU receptor tyrosine kinase gene is amplified in up to 30% of human breast cancers...
  19. Lim H, Dey S, Das S. Differential expression of the erbB2 gene in the periimplantation mouse uterus: potential mediator of signaling by epidermal growth factor-like growth factors. Endocrinology. 1997;138:1328-37 pubmed
    ..epiregulin, and heregulins, whereas the receptor family (the erbB genes) consists of erbB1 (EGF-receptor, EGF-R), erbB2, erbB3, and erbB4...
  20. Crone S, Zhao Y, Fan L, Gu Y, Minamisawa S, Liu Y, et al. ErbB2 is essential in the prevention of dilated cardiomyopathy. Nat Med. 2002;8:459-65 pubmed
    Amplification of the gene encoding the ErbB2 (Her2/neu) receptor tyrosine kinase is critical for the progression of several forms of breast cancer...
  21. Lim H, Das S, Dey S. erbB genes in the mouse uterus: cell-specific signaling by epidermal growth factor (EGF) family of growth factors during implantation. Dev Biol. 1998;204:97-110 pubmed
    ..spatiotemporal expression of various epidermal growth factor (EGF)-like ligands and receptor subtypes, ErbB1 and ErbB2, during the peri-implantation period...
  22. Morris J, Lin W, Hauser C, Marchuk Y, Getman D, Lee K. Rescue of the cardiac defect in ErbB2 mutant mice reveals essential roles of ErbB2 in peripheral nervous system development. Neuron. 1999;23:273-83 pubmed
    b>ErbB2 receptor tyrosine kinase plays a role in neuregulin signaling and is expressed in the developing nervous system. We genetically rescued the cardiac defect of erbB2 null mutant embryos, which otherwise died at E11...
  23. Yamaoka T, Yan F, Cao H, Hobbs S, Dise R, Tong W, et al. Transactivation of EGF receptor and ErbB2 protects intestinal epithelial cells from TNF-induced apoptosis. Proc Natl Acad Sci U S A. 2008;105:11772-7 pubmed publisher
    ..This study was undertaken to determine the effects of TNF on EGFR and ErbB2 activation and intestinal epithelial cell survival...
  24. Ghashghaei H, Weimer J, Schmid R, Yokota Y, McCarthy K, Popko B, et al. Reinduction of ErbB2 in astrocytes promotes radial glial progenitor identity in adult cerebral cortex. Genes Dev. 2007;21:3258-71 pubmed
    ..Here we show that the in vivo induction of the tyrosine kinase receptor, ErbB2, in mature astrocytes enables a subset of them to regain radial glial identity in the mature cerebral cortex...
  25. Hentges K, Nakamura H, Furuta Y, Yu Y, Thompson D, O BRIEN W, et al. Novel lethal mouse mutants produced in balancer chromosome screens. Gene Expr Patterns. 2006;6:653-65 pubmed
  26. Miettinen P, Huotari M, Koivisto T, Ustinov J, Palgi J, Rasilainen S, et al. Impaired migration and delayed differentiation of pancreatic islet cells in mice lacking EGF-receptors. Development. 2000;127:2617-27 pubmed
    ..Upregulated PAI-1 production and decreased gelatinolytic activity correlated to this migration defect. An intact EGF-R pathway appears to be a prerequisite for normal pancreatic development. ..
  27. Whelan K, Schwab L, Karakashev S, Franchetti L, Johannes G, Seagroves T, et al. The oncogene HER2/neu (ERBB2) requires the hypoxia-inducible factor HIF-1 for mammary tumor growth and anoikis resistance. J Biol Chem. 2013;288:15865-77 pubmed publisher
    b>ERBB2, a receptor tyrosine kinase amplified in breast cancer, is a well established regulator of tumor growth in vivo and anoikis resistance leading to disruption of architecture in three-dimensional mammary epithelial acinar structures ..
  28. Michailov G, Sereda M, Brinkmann B, Fischer T, Haug B, Birchmeier C, et al. Axonal neuregulin-1 regulates myelin sheath thickness. Science. 2004;304:700-3 pubmed
    ..We suggest a model by which myelin-forming Schwann cells integrate axonal Nrg1 signals as a biochemical measure of axon size. ..
  29. Escher P, Lacazette E, Courtet M, Blindenbacher A, Landmann L, Bezakova G, et al. Synapses form in skeletal muscles lacking neuregulin receptors. Science. 2005;308:1920-3 pubmed
    ..Here, we demonstrate that NMJs can form in the absence of the NRG receptors ErbB2 and ErbB4 in mouse muscle. Postsynaptic differentiation is, however, induced by Agrin...
  30. Kile B, Hentges K, Clark A, Nakamura H, Salinger A, Liu B, et al. Functional genetic analysis of mouse chromosome 11. Nature. 2003;425:81-6 pubmed
    ..The mutations reveal new defects in haematopoiesis, craniofacial and cardiovascular development, and fertility. ..
  31. Wang Q, Li S, Wang H, Xiao Y, Sahin O, Brady S, et al. Concomitant targeting of tumor cells and induction of T-cell response synergizes to effectively inhibit trastuzumab-resistant breast cancer. Cancer Res. 2012;72:4417-28 pubmed
    Trastuzumab is an iconic rationally designed targeted therapy for HER2-positive breast cancers. However, the low response rate and development of resistance call for novel approaches for the treatment of patients...
  32. Toneff M, Du Z, Dong J, Huang J, Sinai P, Forman J, et al. Somatic expression of PyMT or activated ErbB2 induces estrogen-independent mammary tumorigenesis. Neoplasia. 2010;12:718-26 pubmed
    ..mimics the evolution of sporadic human breast cancers, mammary epithelial cells harboring PyMT or activated ErbB2 evolve into tumors independent of estrogen or other ovarian functions in contrast to previous observations of ..
  33. Schade B, Lesurf R, Sanguin Gendreau V, Bui T, Deblois G, O Toole S, et al. ?-Catenin signaling is a critical event in ErbB2-mediated mammary tumor progression. Cancer Res. 2013;73:4474-87 pubmed publisher
    Although ERBB2 amplification and overexpression is correlated with poor outcome in breast cancer, the molecular mechanisms underlying the aggressive nature of these tumors has not been fully elucidated...
  34. Guy C, Cardiff R, Muller W. Activated neu induces rapid tumor progression. J Biol Chem. 1996;271:7673-8 pubmed
    Expression of the activated neu oncogene in transgenic mice has been associated with both the synchronous (single-step) and the stochastic (multistep) transformation of the mammary epithelium...
  35. Muller W, Sinn E, Pattengale P, Wallace R, Leder P. Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene. Cell. 1988;54:105-15 pubmed
    We have used transgenic mice that carry an activated c-neu oncogene driven by a mouse mammary tumor virus (MMTV) promoter to assess the stepwise progression of carcinogenesis in mammary epithelium...
  36. Erickson S, O Shea K, Ghaboosi N, Loverro L, Frantz G, Bauer M, et al. ErbB3 is required for normal cerebellar and cardiac development: a comparison with ErbB2-and heregulin-deficient mice. Development. 1997;124:4999-5011 pubmed
    ..to ErbB3 and ErbB4 receptors, leading to multiple dimerization possibilities including heterodimerization with the ErbB2 receptor...
  37. Siegel P, Dankort D, Hardy W, Muller W. Novel activating mutations in the neu proto-oncogene involved in induction of mammary tumors. Mol Cell Biol. 1994;14:7068-77 pubmed
    Amplification of the Neu/c-erbB-2 receptor tyrosine kinase has been implicated as an important event in the genesis of human breast cancer...
  38. Hanker A, Pfefferle A, Balko J, Kuba M, Young C, Sanchez V, et al. Mutant PIK3CA accelerates HER2-driven transgenic mammary tumors and induces resistance to combinations of anti-HER2 therapies. Proc Natl Acad Sci U S A. 2013;110:14372-7 pubmed publisher
    Human epidermal growth factor receptor 2 (HER2; ERBB2) amplification and phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (PIK3CA) mutations often co-occur in breast cancer...
  39. Britsch S, Li L, Kirchhoff S, Theuring F, Brinkmann V, Birchmeier C, et al. The ErbB2 and ErbB3 receptors and their ligand, neuregulin-1, are essential for development of the sympathetic nervous system. Genes Dev. 1998;12:1825-36 pubmed
    ..Here, we report a novel phenotype in mice with targeted mutations in the erbB2, erbB3, or neuregulin-1 genes...
  40. Boles M, Wilkinson B, Wilming L, Liu B, Probst F, Harrow J, et al. Discovery of candidate disease genes in ENU-induced mouse mutants by large-scale sequencing, including a splice-site mutation in nucleoredoxin. PLoS Genet. 2009;5:e1000759 pubmed publisher
    ..Our data show that the classical positional mapping approach of disease mutation identification can be extended to large target regions using high-throughput sequencing. ..
  41. Hewitt S, Bocchinfuso W, Zhai J, Harrell C, Koonce L, Clark J, et al. Lack of ductal development in the absence of functional estrogen receptor alpha delays mammary tumor formation induced by transgenic expression of ErbB2/neu. Cancer Res. 2002;62:2798-805 pubmed
    Expression of the mouse mammary tumor virus (MMTV) neu/erbB2 transgene in mice induces mammary tumors...
  42. Camenisch T, Schroeder J, Bradley J, Klewer S, McDonald J. Heart-valve mesenchyme formation is dependent on hyaluronan-augmented activation of ErbB2-ErbB3 receptors. Nat Med. 2002;8:850-5 pubmed
    ..which normally lack mesenchyme formation, are rescued by heregulin treatment, which restores phosphorylation of ErbB2 and ErbB3...
  43. Lee Hoeflich S, Crocker L, Yao E, Pham T, Munroe X, Hoeflich K, et al. A central role for HER3 in HER2-amplified breast cancer: implications for targeted therapy. Cancer Res. 2008;68:5878-87 pubmed publisher
    Epidermal growth factor receptor (EGFR) and HER3 each form heterodimers with HER2 and have independently been implicated as key coreceptors that drive HER2-amplified breast cancer...
  44. Schmid R, McGrath B, Berechid B, Boyles B, Marchionni M, Sestan N, et al. Neuregulin 1-erbB2 signaling is required for the establishment of radial glia and their transformation into astrocytes in cerebral cortex. Proc Natl Acad Sci U S A. 2003;100:4251-6 pubmed
    ..Down-regulation of expression and activity of erbB2, a member of the NRG-1 receptor complex, leads to the transformation of radial glial cells into astrocytes...
  45. Garratt A, Voiculescu O, Topilko P, Charnay P, Birchmeier C. A dual role of erbB2 in myelination and in expansion of the schwann cell precursor pool. J Cell Biol. 2000;148:1035-46 pubmed
    ..axonally derived signal for the survival and growth of developing Schwann cells, which is transmitted by the ErbB2/ErbB3 receptor tyrosine kinases...
  46. Belmonte F, Das S, Sysa Shah P, Sivakumaran V, Stanley B, Guo X, et al. ErbB2 overexpression upregulates antioxidant enzymes, reduces basal levels of reactive oxygen species, and protects against doxorubicin cardiotoxicity. Am J Physiol Heart Circ Physiol. 2015;309:H1271-80 pubmed publisher
    Levels of the HER2/ErbB2 protein in the heart are upregulated in some women during breast cancer therapy, and these women are at high risk for developing heart dysfunction after sequential treatment with anti-ErbB2/trastuzumab or ..
  47. Abraham J, Prajapati S, Nishijo K, Schaffer B, Taniguchi E, Kilcoyne A, et al. Evasion mechanisms to Igf1r inhibition in rhabdomyosarcoma. Mol Cancer Ther. 2011;10:697-707 pubmed publisher
    ..However, drug resistance in vivo is more common and is accompanied by Igf1r overexpression, Mapk reactivation, and Her2 overexpression...
  48. Shepherd T, Kockeritz L, Szrajber M, Muller W, Hassell J. The pea3 subfamily ets genes are required for HER2/Neu-mediated mammary oncogenesis. Curr Biol. 2001;11:1739-48 pubmed
    ..transcription factor is overexpressed in the vast majority of human breast tumors and in nearly all of those of the HER2/Neu-positive subclass. PEA3 is also overexpressed in various transgenic mouse models of this disease...
  49. Schmidt N, Akaaboune M, Gajendran N, Martinez Pena y Valenzuela I, Wakefield S, Thurnheer R, et al. Neuregulin/ErbB regulate neuromuscular junction development by phosphorylation of ?-dystrobrevin. J Cell Biol. 2011;195:1171-84 pubmed publisher
    ..Our data indicate that NRG/ErbB signaling maintains high efficacy of synaptic transmission by stabilizing the postsynaptic apparatus via phosphorylation of ?-dystrobrevin1. ..
  50. Ray D, Terao Y, Christov K, Kaldis P, Kiyokawa H. Cdk2-null mice are resistant to ErbB-2-induced mammary tumorigenesis. Neoplasia. 2011;13:439-44 pubmed
    ..of cell types, resulting in near-normal mouse development, whereas such loss of Cdk4 completely abrogated ErbB-2/neu-induced mammary tumorigenesis in mice...
  51. Klimcakova E, Chénard V, McGuirk S, Germain D, Avizonis D, Muller W, et al. PGC-1? promotes the growth of ErbB2/Neu-induced mammary tumors by regulating nutrient supply. Cancer Res. 2012;72:1538-46 pubmed publisher
    ..Specifically, we increased mitochondrial metabolism in a murine cellular model of ErbB2/Neu-induced breast cancer by ectopically expressing the transcriptional coactivator peroxisome proliferator-..
  52. Harmelink C, Peng Y, Debenedittis P, Chen H, Shou W, Jiao K. Myocardial Mycn is essential for mouse ventricular wall morphogenesis. Dev Biol. 2013;373:53-63 pubmed publisher
    ..In summary, Mycn acts downstream of BMP and NRG1 cardiogenic signaling pathways to promote normal myocardial wall morphogenesis. ..
  53. Kiguchi K, Carbajal S, Chan K, Beltran L, Ruffino L, Shen J, et al. Constitutive expression of ErbB-2 in gallbladder epithelium results in development of adenocarcinoma. Cancer Res. 2001;61:6971-6 pubmed
    ..These mice represent a unique new animal model for studying biliary tract carcinogenesis. ..
  54. Sequeira S, Wen H, Avivar Valderas A, Farias E, Aguirre Ghiso J. Inhibition of eIF2alpha dephosphorylation inhibits ErbB2-induced deregulation of mammary acinar morphogenesis. BMC Cell Biol. 2009;10:64 pubmed publisher
    The ErbB2/Her2/Neu receptor tyrosine kinase is amplified in approximately 30% of human breast cancers...
  55. Rao G, Ney E, Herbert R. Effect of melatonin and linolenic acid on mammary cancer in transgenic mice with c-neu breast cancer oncogene. Breast Cancer Res Treat. 2000;64:287-96 pubmed
    ..NK model. Four-week-old hemizygous TG.NK female mice with MMTV/c-neu oncogene fed NTP-2000 diet were gavaged with 0.05-0...
  56. Gondi C, Dinh D, Klopfenstein J, Gujrati M, Rao J. MMP-2 downregulation mediates differential regulation of cell death via ErbB-2 in glioma xenografts. Int J Oncol. 2009;35:257-63 pubmed
    ..Our results suggest that MMP-2 may play a role in a hitherto unknown signaling pathway mediated via ErbB-2 in certain cancer cell types. ..
  57. Guo W, Pylayeva Y, Pepe A, Yoshioka T, Muller W, Inghirami G, et al. Beta 4 integrin amplifies ErbB2 signaling to promote mammary tumorigenesis. Cell. 2006;126:489-502 pubmed
    Amplification of the ErbB2 locus, which encodes a receptor tyrosine kinase, is common in aggressive breast tumors and correlates with poor prognosis...
  58. Voutsas I, Gritzapis A, Mahaira L, Salagianni M, Von Hofe E, Kallinteris N, et al. Induction of potent CD4+ T cell-mediated antitumor responses by a helper HER-2/neu peptide linked to the Ii-Key moiety of the invariant chain. Int J Cancer. 2007;121:2031-41 pubmed
    ..to either syngeneic dendritic cells pulsed with native peptide, or HLA-DR4+ human tumor cell lines expressing HER-2/neu. Hybrid peptides were more stable in an off-rate kinetics assay compared to the native peptide...
  59. Chang Y, Seldin M, Fitzgerald L, Lalley P. Conservation of the linkage of the murine Itga2b and Itgb3 loci in mouse chromosome 11. Mamm Genome. 1999;10:530-1 pubmed
  60. Arun G, Diermeier S, Akerman M, Chang K, Wilkinson J, Hearn S, et al. Differentiation of mammary tumors and reduction in metastasis upon Malat1 lncRNA loss. Genes Dev. 2016;30:34-51 pubmed publisher
    ..Furthermore, Malat1 loss results in a reduction of branching morphogenesis in MMTV-PyMT- and Her2/neu-amplified tumor organoids, increased cell adhesion, and loss of migration...