Gene Symbol: Epor
Description: erythropoietin receptor
Alias: erythropoietin receptor, EPO-R
Species: mouse
Products:     Epor

Top Publications

  1. Heinrich A, Pelanda R, Klingmuller U. A mouse model for visualization and conditional mutations in the erythroid lineage. Blood. 2004;104:659-66 pubmed
    ..mouse model (ErGFPcre) that expresses an improved GFPcre fusion protein controlled by the endogenous erythropoietin receptor (EpoR) promoter...
  2. Brines M, Grasso G, Fiordaliso F, Sfacteria A, Ghezzi P, Fratelli M, et al. Erythropoietin mediates tissue protection through an erythropoietin and common beta-subunit heteroreceptor. Proc Natl Acad Sci U S A. 2004;101:14907-12 pubmed
    ..We have recently characterized Epo derivatives that do not bind to the Epo receptor (EpoR) yet are tissue-protective...
  3. Dumitriu B, Dy P, Smits P, Lefebvre V. Generation of mice harboring a Sox6 conditional null allele. Genesis. 2006;44:219-24 pubmed
    ..Sox6(fl+/fl+) mice are indistinguishable from wildtype mice, and Sox6(fl-/fl-) mice from Sox6(-/-) mice. These Sox6 conditional null mice will thus be valuable for further uncovering the roles of Sox6 in various processes in vivo. ..
  4. Bulut G, Sulahian R, Ma Y, Chi N, Huang L. Ubiquitination regulates the internalization, endolysosomal sorting, and signaling of the erythropoietin receptor. J Biol Chem. 2011;286:6449-57 pubmed publisher
    ..Here, we show that ubiquitination of the erythropoietin receptor (EpoR) at Lys(256) is necessary and sufficient for efficient Epo-induced receptor internalization, ..
  5. Wu H, Liu X, Jaenisch R, Lodish H. Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor. Cell. 1995;83:59-67 pubmed
    ..We introduced null mutations into both Epo and the EPO receptor (EpoR) gene. Both heterozygotes appeared normal...
  6. Cheng J, Kang X, Zhang S, Yeh E. SUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxia. Cell. 2007;131:584-95 pubmed
    ..These results show that SENP1 plays a key role in the regulation of the hypoxic response through regulation of HIF1alpha stability and that SUMOylation can serve as a direct signal for ubiquitin-dependent degradation. ..
  7. Chen Z, Asavaritikrai P, Prchal J, Noguchi C. Endogenous erythropoietin signaling is required for normal neural progenitor cell proliferation. J Biol Chem. 2007;282:25875-83 pubmed
    Erythropoietin (Epo) and its receptor (EpoR), critical for erythropoiesis, are expressed in the nervous system...
  8. Kieran M, Perkins A, Orkin S, Zon L. Thrombopoietin rescues in vitro erythroid colony formation from mouse embryos lacking the erythropoietin receptor. Proc Natl Acad Sci U S A. 1996;93:9126-31 pubmed
    The interaction of the hormone erythropoietin and its receptor (EpoR) is though to be required for normal hematopoiesis. To define the role of EpoR in this process, the murine EpoR was disrupted by homologous recombination...
  9. Fang J, Menon M, Kapelle W, Bogacheva O, Bogachev O, Houde E, et al. EPO modulation of cell-cycle regulatory genes, and cell division, in primary bone marrow erythroblasts. Blood. 2007;110:2361-70 pubmed
    ..Furthermore, erythroblasts expressing a on PY-null EPOR-HM allele were abnormally distributed in G0/G1...

More Information


  1. David R, Lim G, Moritz K, Koukoulas I, Wintour E. Quantitation of the mRNA levels of Epo and EpoR in various tissues in the ovine fetus. Mol Cell Endocrinol. 2002;188:207-18 pubmed
    A partial cDNA of the sheep erythropoietin receptor (EpoR) was obtained and used in real-time PCR to quantitate mRNA levels in placenta, liver and kidney throughout development (term=150 days)...
  2. Wojchowski D, Menon M, Sathyanarayana P, Fang J, Karur V, Houde E, et al. Erythropoietin-dependent erythropoiesis: New insights and questions. Blood Cells Mol Dis. 2006;36:232-8 pubmed
    ..for the first time) the signaling capacities of two knocked-in phosphotyrosine-deficient Epo receptor alleles (EpoR-H and EpoR-HM)...
  3. Menon M, Karur V, Bogacheva O, Bogachev O, Cuetara B, Wojchowski D. Signals for stress erythropoiesis are integrated via an erythropoietin receptor-phosphotyrosine-343-Stat5 axis. J Clin Invest. 2006;116:683-94 pubmed
    ..In mice expressing a phosphotyrosine-null (PY-null) Epo receptor allele (EpoR-HM), severe and persistent anemia was induced by hemolysis or 5-fluorouracil...
  4. Echigoya M, Obikane K, Nakashima T, Sasaki S. Glomerular localization of erythropoietin receptor mRNA and protein in neonatal and mature mouse kidney. Nephron Exp Nephrol. 2005;100:e21-9 pubmed
    ..EPO-R is expressed in developing and mature podocytes in mouse kidney, suggesting a possible role for EPO in podocyte biology. ..
  5. Zang H, Sato K, Nakajima H, McKay C, Ney P, Ihle J. The distal region and receptor tyrosines of the Epo receptor are non-essential for in vivo erythropoiesis. EMBO J. 2001;20:3156-66 pubmed
    The erythropoietin receptor (EpoR) is required for the proliferation and survival of committed erythroid lineage cells...
  6. D Andrea A, Lodish H, Wong G. Expression cloning of the murine erythropoietin receptor. Cell. 1989;57:277-85 pubmed
    Two independent cDNA clones encoding the erythropoietin receptor (EPO-R) were isolated from a pXM expression library made from uninduced murine erythroleukemia (MEL) cells...
  7. Ketteler R, Heinrich A, Offe J, Becker V, Cohen J, Neumann D, et al. A functional green fluorescent protein-erythropoietin receptor despite physical separation of JAK2 binding site and tyrosine residues. J Biol Chem. 2002;277:26547-52 pubmed
    Signaling through hematopoietic cytokine receptors such as the erythropoietin receptor (EpoR) depends on the activation of a receptor-bound Janus kinase (JAK) and tyrosine phosphorylation of the cytoplasmic domain...
  8. Satoh K, Kagaya Y, Nakano M, Ito Y, Ohta J, Tada H, et al. Important role of endogenous erythropoietin system in recruitment of endothelial progenitor cells in hypoxia-induced pulmonary hypertension in mice. Circulation. 2006;113:1442-50 pubmed
    ..pressure, right ventricular hypertrophy, and pulmonary vascular remodeling in mice lacking the Epo receptor (EpoR) in nonerythroid lineages (EpoR(-/-) rescued mice) after 3 weeks of exposure to hypoxia...
  9. Sathyanarayana P, Menon M, Bogacheva O, Bogachev O, Niss K, Kapelle W, et al. Erythropoietin modulation of podocalyxin and a proposed erythroblast niche. Blood. 2007;110:509-18 pubmed
    ..As studied in erythroblasts expressing minimal Epo receptor (EpoR) alleles, efficient PODXL induction proved dependence on an EpoR-PY343 Stat5 binding site...
  10. Soliz J, Gassmann M, Joseph V. Soluble erythropoietin receptor is present in the mouse brain and is required for the ventilatory acclimatization to hypoxia. J Physiol. 2007;583:329-36 pubmed
    While erythropoietin (Epo) and its receptor (EpoR) have been widely investigated in brain, the expression and function of the soluble Epo receptor (sEpoR) remain unknown...
  11. Sathyanarayana P, Dev A, Fang J, Houde E, Bogacheva O, Bogachev O, et al. EPO receptor circuits for primary erythroblast survival. Blood. 2008;111:5390-9 pubmed publisher
    ..Two proapoptotic factors, Bim and FoxO3a, were rapidly repressed not only via the wild-type EPOR, but also by PY-deficient knocked-in EPOR alleles. In parallel, Pim1 and Pim3 kinases and Irs2 were induced...
  12. Weiss M, Keller G, Orkin S. Novel insights into erythroid development revealed through in vitro differentiation of GATA-1 embryonic stem cells. Genes Dev. 1994;8:1184-97 pubmed
    ..The approach used here is a paradigm for the phenotypic analysis of targeted mutations affecting hematopoietic development. ..
  13. Barron C, Migliaccio A, Migliaccio G, Jiang Y, Adamson J, Ottolenghi S. Alternatively spliced mRNAs encoding soluble isoforms of the erythropoietin receptor in murine cell lines and bone marrow. Gene. 1994;147:263-8 pubmed
    ..We have now analyzed the EpoR mRNA from the 32D GM line, using PCR followed by direct sequencing...
  14. Liu Z, Chin K, Noguchi C. Tissue specific expression of human erythropoietin receptor in transgenic mice. Dev Biol. 1994;166:159-69 pubmed
    We have made transgenic mice using the human erythropoietin receptor (hEpoR) encoding gene contained within a 15-kb DNA fragment...
  15. Nairz M, Schroll A, Moschen A, Sonnweber T, Theurl M, Theurl I, et al. Erythropoietin contrastingly affects bacterial infection and experimental colitis by inhibiting nuclear factor-?B-inducible immune pathways. Immunity. 2011;34:61-74 pubmed publisher
    Erythropoietin (EPO) is the principal cytokine regulating erythropoiesis through its receptor, EPOR. Interestingly, EPORs are also found on immune cells with incompletely understood functions...
  16. Choi D, Schroer S, Lu S, Wang L, Wu X, Liu Y, et al. Erythropoietin protects against diabetes through direct effects on pancreatic beta cells. J Exp Med. 2010;207:2831-42 pubmed publisher
    ..Thus, promotion of EPO signaling in ? cells may be a novel therapeutic strategy for diabetes prevention and treatment. ..
  17. Yu X, Shacka J, Eells J, Suarez Quian C, Przygodzki R, Beleslin Cokic B, et al. Erythropoietin receptor signalling is required for normal brain development. Development. 2002;129:505-16 pubmed
    ..Although high levels of erythropoietin receptor are produced in embryonic brain, the role of erythropoietin during brain development is uncertain...
  18. Nakano M, Satoh K, Fukumoto Y, Ito Y, Kagaya Y, Ishii N, et al. Important role of erythropoietin receptor to promote VEGF expression and angiogenesis in peripheral ischemia in mice. Circ Res. 2007;100:662-9 pubmed
    We have recently demonstrated that endogenous erythropoietin (Epo)/Epo receptor (EpoR) system plays an important protective role in hypoxia-induced pulmonary hypertension...
  19. Morita M, Ohneda O, Yamashita T, Takahashi S, Suzuki N, Nakajima O, et al. HLF/HIF-2alpha is a key factor in retinopathy of prematurity in association with erythropoietin. EMBO J. 2003;22:1134-46 pubmed
    ..Together with the results from intraperitoneal injection of Epo into HLF(kd/kd) mouse, this suggests that Epo is one of the target genes of HLF responsible for experimental ROP. ..
  20. Menon M, Fang J, Wojchowski D. Core erythropoietin receptor signals for late erythroblast development. Blood. 2006;107:2662-72 pubmed
    Critical signals for erythroblast formation are transduced by activated, tyrosine-phosphorylated erythropoietin receptor (EpoR) complexes...
  21. Singbrant S, Russell M, Jovic T, Liddicoat B, Izon D, Purton L, et al. Erythropoietin couples erythropoiesis, B-lymphopoiesis, and bone homeostasis within the bone marrow microenvironment. Blood. 2011;117:5631-42 pubmed publisher
    ..These data demonstrate a previously unrecognized in vivo regulatory network coordinating erythropoiesis, B-lymphopoiesis, and skeletal homeostasis. Importantly, these findings may be relevant to the clinical application of Epo. ..
  22. Youssoufian H, Zon L, Orkin S, D Andrea A, Lodish H. Structure and transcription of the mouse erythropoietin receptor gene. Mol Cell Biol. 1990;10:3675-82 pubmed
    The complete gene encoding the mouse erythropoietin receptor was isolated by using a cDNA probe derived from a mouse erythroleukemia (MEL) cell library...
  23. Xiong Y, Mahmood A, Lu D, Qu C, Kazmi H, Goussev A, et al. Histological and functional outcomes after traumatic brain injury in mice null for the erythropoietin receptor in the central nervous system. Brain Res. 2008;1230:247-57 pubmed publisher
    Erythropoietin (EPO) and its receptor (EPOR), essential for erythropoiesis, are expressed in the nervous system...
  24. Xu J, Bauer D, Kerenyi M, Vo T, Hou S, Hsu Y, et al. Corepressor-dependent silencing of fetal hemoglobin expression by BCL11A. Proc Natl Acad Sci U S A. 2013;110:6518-23 pubmed publisher
    ..Our findings provide important insights into the mechanistic roles of BCL11A in HbF silencing and clues for therapeutic targeting of BCL11A in ?-hemoglobinopathies. ..
  25. Quelle F, Wang D, Nosaka T, Thierfelder W, Stravopodis D, Weinstein Y, et al. Erythropoietin induces activation of Stat5 through association with specific tyrosines on the receptor that are not required for a mitogenic response. Mol Cell Biol. 1996;16:1622-31 pubmed
    The cytoplasmic domain of the erythropoietin receptor (EpoR) contains a membrane-distal region that is dispensable for mitogenesis but is required for the recruitment and tyrosine phosphorylation of a variety of signaling proteins...
  26. Suzuki N, Suwabe N, Ohneda O, Obara N, Imagawa S, Pan X, et al. Identification and characterization of 2 types of erythroid progenitors that express GATA-1 at distinct levels. Blood. 2003;102:3575-83 pubmed
    ..This study also presents an efficient method for enriching the CFU-E and BFU-E from mouse hematopoietic tissues. ..
  27. Lin C, Lim S, D AGATI V, Costantini F. Differential effects of an erythropoietin receptor gene disruption on primitive and definitive erythropoiesis. Genes Dev. 1996;10:154-64 pubmed
    Although the hormone erythropoietin (Epo) and its receptor (EpoR) are known to play important roles in the regulation of erythropoiesis, several questions remain concerning the developmental role of Epo/EpoR signaling...
  28. Huang L, Constantinescu S, Lodish H. The N-terminal domain of Janus kinase 2 is required for Golgi processing and cell surface expression of erythropoietin receptor. Mol Cell. 2001;8:1327-38 pubmed
    We show that Janus kinase 2 (JAK2), and more specifically just its intact N-terminal domain, binds to the erythropoietin receptor (EpoR) in the endoplasmic reticulum and promotes its cell surface expression...
  29. Suzuki N, Ohneda O, Takahashi S, Higuchi M, Mukai H, Nakahata T, et al. Erythroid-specific expression of the erythropoietin receptor rescued its null mutant mice from lethality. Blood. 2002;100:2279-88 pubmed
    Erythropoietin (Epo) and its receptor (EpoR) are indispensable to erythropoiesis...
  30. Lee R, Kertesz N, Joseph S, Jegalian A, Wu H. Erythropoietin (Epo) and EpoR expression and 2 waves of erythropoiesis. Blood. 2001;98:1408-15 pubmed
    ..In this study, it is proposed that erythropoietin (Epo) expression and the resultant EpoR activation regulate the timing of the definitive wave...
  31. Koulnis M, Porpiglia E, Porpiglia P, Liu Y, Hallstrom K, Hidalgo D, et al. Contrasting dynamic responses in vivo of the Bcl-xL and Bim erythropoietic survival pathways. Blood. 2012;119:1228-39 pubmed publisher
    Survival signaling by the erythropoietin (Epo) receptor (EpoR) is essential for erythropoiesis and for its acceleration in hypoxic stress...
  32. Tsai P, Ohab J, Kertesz N, Groszer M, Matter C, Gao J, et al. A critical role of erythropoietin receptor in neurogenesis and post-stroke recovery. J Neurosci. 2006;26:1269-74 pubmed
    ..Using a genetic approach, we evaluate the roles of endogenous EPO and its classical receptor (EPOR) in mammalian neurogenesis...
  33. Dev A, Fang J, Sathyanarayana P, Pradeep A, Emerson C, Wojchowski D. During EPO or anemia challenge, erythroid progenitor cells transit through a selectively expandable proerythroblast pool. Blood. 2010;116:5334-46 pubmed publisher
    ..Possible erythropoietin/erythropoietin receptor proerythroblast stage specific events were further investigated in mice expressing minimal erythropoietin ..
  34. Yu X, Lin C, Costantini F, Noguchi C. The human erythropoietin receptor gene rescues erythropoiesis and developmental defects in the erythropoietin receptor null mouse. Blood. 2001;98:475-7 pubmed
    ..Mice lacking the erythropoietin receptor exhibit severe anemia and die at about embryonic day 13.5...
  35. Parganas E, Wang D, Stravopodis D, Topham D, Marine J, Teglund S, et al. Jak2 is essential for signaling through a variety of cytokine receptors. Cell. 1998;93:385-95 pubmed
    ..Therefore, Jak2 plays a critical, nonredundant role in the function of a specific group of cytokines receptors. ..
  36. Dumitriu B, Patrick M, Petschek J, Cherukuri S, Klingmuller U, Fox P, et al. Sox6 cell-autonomously stimulates erythroid cell survival, proliferation, and terminal maturation and is thereby an important enhancer of definitive erythropoiesis during mouse development. Blood. 2006;108:1198-207 pubmed
    ..Sox6 thus enhances erythroid cell development at multiple levels and thereby ensures adequate production and quality of red blood cells. ..
  37. Elliott S, Busse L, Bass M, Lu H, Sarosi I, Sinclair A, et al. Anti-Epo receptor antibodies do not predict Epo receptor expression. Blood. 2006;107:1892-5 pubmed
    Investigators using anti-EpoR antibodies for immunoblotting and immunostaining have reported erythropoietin receptor (EpoR) expression in nonhematopoietic tissues including human tumors...
  38. He T, Zhuang H, Jiang N, Waterfield M, Wojchowski D. Association of the p85 regulatory subunit of phosphatidylinositol 3-kinase with an essential erythropoietin receptor subdomain. Blood. 1993;82:3530-8 pubmed
    ..These findings extend a mechanistic alignment between the EPO receptor and protein tyrosine kinase-encoding receptors that likewise activate PI3-K, and expand the importance of further defining pathways to PI3-K activation. ..
  39. Digicaylioglu M, Bichet S, Marti H, Wenger R, Rivas L, Bauer C, et al. Localization of specific erythropoietin binding sites in defined areas of the mouse brain. Proc Natl Acad Sci U S A. 1995;92:3717-20 pubmed
    ..Major EPO binding sites were observed in the hippocampus, capsula interna, cortex, and midbrain areas. Functional expression of the EPO-R and hypoxic upregulation of EPO suggest a role of EPO in the brain. ..
  40. Rouleau C, Cui K, Feldman L. A functional erythropoietin receptor is necessary for the action of thrombopoietin on erythroid cells lacking c-mpl. Exp Hematol. 2004;32:140-8 pubmed
    ..its mitogenic effects on erythroid cells, at least in part, via an interaction of TPO with the cells' erythropoietin receptor (EPO-R)...
  41. Carraway M, Suliman H, Jones W, Chen C, Babiker A, Piantadosi C. Erythropoietin activates mitochondrial biogenesis and couples red cell mass to mitochondrial mass in the heart. Circ Res. 2010;106:1722-30 pubmed publisher
    ..We examined the hypothesis that EPO receptor (EpoR) ligand-binding, which activates endothelial NO synthase (eNOS), regulates the prosurvival program of mitochondrial ..
  42. Kertesz N, Wu J, Chen T, Sucov H, Wu H. The role of erythropoietin in regulating angiogenesis. Dev Biol. 2004;276:101-10 pubmed
    ..In this study, we demonstrate a novel role of EPO in regulating angiogenesis in vivo. Epo and Epo receptor (EpoR) are expressed in the vasculature during embryogenesis...
  43. Wu H, Lee S, Gao J, Liu X, Iruela Arispe M. Inactivation of erythropoietin leads to defects in cardiac morphogenesis. Development. 1999;126:3597-605 pubmed
    ..Erythropoietin(-/-) and erythropoietin receptor(-/-) mouse embryos die around embryonic day 13...
  44. Teng R, Gavrilova O, Suzuki N, Chanturiya T, Schimel D, Hugendubler L, et al. Disrupted erythropoietin signalling promotes obesity and alters hypothalamus proopiomelanocortin production. Nat Commun. 2011;2:520 pubmed publisher
    Although erythropoietin (Epo) is the cytokine known to regulate erythropoiesis, erythropoietin receptor (EpoR) expression and associated activity beyond haematopoietic tissue remain uncertain...
  45. Lu X, Gross A, Lodish H. Active conformation of the erythropoietin receptor: random and cysteine-scanning mutagenesis of the extracellular juxtamembrane and transmembrane domains. J Biol Chem. 2006;281:7002-11 pubmed
    In the absence of erythropoietin (Epo) cell surface Epo receptors (EpoR) are dimeric; dimerization is mediated mainly by the transmembrane domain. Binding of Epo changes the orientation of the two receptor subunits...
  46. Okada H, Watanabe T, Niki M, Takano H, Chiba N, Yanai N, et al. AML1(-/-) embryos do not express certain hematopoiesis-related gene transcripts including those of the PU.1 gene. Oncogene. 1998;17:2287-93 pubmed
    ..The results suggest that the expression of a particular set of hematopoiesis-related genes is closely correlated with the PEBP2/CBF function. ..
  47. Ulyanova T, Padilla S, Papayannopoulou T. Stage-specific functional roles of integrins in murine erythropoiesis. Exp Hematol. 2014;42:404-409.e4 pubmed publisher
    ..By contrast, ?4 integrins whether deleted early or late have a dominant effect on bone marrow retention of erythroblasts and on terminal erythroid maturation at homeostasis and after stress. ..
  48. Dey S, Scullen T, Noguchi C. Erythropoietin negatively regulates pituitary ACTH secretion. Brain Res. 2015;1608:14-20 pubmed publisher
    Erythropoietin (Epo) and Epo-receptor (EpoR) signaling, in addition to its classical role in erythropoiesis, exhibit a protective response in non-hematopoietic tissues...
  49. Pan Y, Shu J, Gu H, Zhou D, Liu X, Qiao Q, et al. Erythropoietin improves insulin resistance via the regulation of its receptor-mediated signaling pathways in 3T3L1 adipocytes. Mol Cell Endocrinol. 2013;367:116-23 pubmed publisher
    ..Endogenous erythropoietin receptor (EPOR) expression was inhibited using small interfering RNA (siRNA)...
  50. Wang L, Teng R, Di L, Rogers H, Wu H, Kopp J, et al. PPAR? and Sirt1 mediate erythropoietin action in increasing metabolic activity and browning of white adipocytes to protect against obesity and metabolic disorders. Diabetes. 2013;62:4122-31 pubmed publisher
    ..Collectively, EPO, as a novel regulator of adipose energy homeostasis via these metabolism coregulators, provides a potential therapeutic strategy to protect against obesity and metabolic disorders. ..
  51. Chakraborti A, Lippman D, Loh H, Kozak C, Lee N. Genetic mapping of opioid binding protein gene(s) to mouse chromosome 9. Mamm Genome. 1993;4:179-82 pubmed
  52. Halupa A, Chohan M, Stickle N, Beattie B, Miller B, Barber D. Erythropoietin receptor Y479 couples to ERK1/2 activation via recruitment of phospholipase Cgamma. Exp Cell Res. 2005;309:1-11 pubmed
    ..Hence, we have identified a novel adapter function for PLCgamma1 in EPO signaling in which recruitment of PLCgamma1 to EPO-R may lead to activation of the ERK pathway. ..
  53. Witthuhn B, Quelle F, Silvennoinen O, Yi T, Tang B, Miura O, et al. JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin. Cell. 1993;74:227-36 pubmed
    ..EPO) regulates the proliferation and differentiation of erythroid cells through interaction with its receptor (EPOR)...
  54. Bulut G, Sulahian R, Yao H, Huang L. Cbl ubiquitination of p85 is essential for Epo-induced EpoR endocytosis. Blood. 2013;122:3964-72 pubmed publisher
    Erythropoietin (Epo) binding to the Epo receptor (EpoR) elicits downstream signaling that is essential for red blood cell production...
  55. Spivak J, Avedissian L, Pierce J, Williams D, Hankins W, Jensen R. Isolation of the full-length murine erythropoietin receptor using a baculovirus expression system. Blood. 1996;87:926-37 pubmed
    The full-length murine erythropoietin receptor was expressed in Spodoptera frugiperda (Sf9) cells using a recombinant baculovirus vector...
  56. Bultman S, Gebuhr T, Magnuson T. A Brg1 mutation that uncouples ATPase activity from chromatin remodeling reveals an essential role for SWI/SNF-related complexes in beta-globin expression and erythroid development. Genes Dev. 2005;19:2849-61 pubmed
    ..Not only does this mutation establish a role for Brg1 during organogenesis, it also demonstrates that ATPase activity can be uncoupled from chromatin remodeling. ..
  57. Yoon D, Watowich S. Hematopoietic cell survival signals are elicited through non-tyrosine-containing sequences in the membrane-proximal region of the erythropoietin receptor (EPOR) by a Stat5-dependent pathway. Exp Hematol. 2003;31:1310-6 pubmed
    ..The erythropoietin receptor (EPOR) elicits both positive and negative regulatory signaling pathways, primarily through phosphorylated ..
  58. Bittorf T, Busfield S, Klinken S, Tilbrook P. Truncated erythropoietin receptor in a murine erythroleukemia cell line. Int J Biochem Cell Biol. 1996;28:175-81 pubmed
    The Friend spleen focus forming virus produces a 55 kDa envelope glycoprotein which associates with the erythropoietin receptor. We compared the erythropoietin receptor in Friend virus transformed murine erythroleukemic F4N and 707 cell ..
  59. Song A, Zhang Y, Han L, Yegutkin G, Liu H, Sun K, et al. Erythrocytes retain hypoxic adenosine response for faster acclimatization upon re-ascent. Nat Commun. 2017;8:14108 pubmed publisher
    ..Our findings suggest that targeting identified purinergic-signalling network would enhance the hypoxia adenosine response to counteract hypoxia-induced maladaptation. ..
  60. Serrano M, Lee H, Chin L, Cordon Cardo C, Beach D, DePinho R. Role of the INK4a locus in tumor suppression and cell mortality. Cell. 1996;85:27-37 pubmed
    ..These findings directly demonstrate that the INK4a locus functions to suppress neoplastic growth. ..