Epo

Summary

Gene Symbol: Epo
Description: erythropoietin
Alias: erythropoietin
Species: mouse
Products:     Epo

Top Publications

  1. Maxwell P, Osmond M, Pugh C, Heryet A, Nicholls L, Tan C, et al. Identification of the renal erythropoietin-producing cells using transgenic mice. Kidney Int. 1993;44:1149-62 pubmed
    Regulation of erythropoietin production by the kidneys is central to the control of erythropoiesis. Uncertainty about the identity of the renal cells involved has been a major obstacle to understanding this mechanism...
  2. Chen J, Connor K, Aderman C, Smith L. Erythropoietin deficiency decreases vascular stability in mice. J Clin Invest. 2008;118:526-33 pubmed publisher
    b>Erythropoietin (Epo), a hormone known to stimulate bone marrow erythrocyte production, is widely used to treat anemia in patients at risk for vascular disease. However, the effects of Epo on angiogenesis are not well defined...
  3. Zeigler B, Vajdos J, Qin W, Loverro L, Niss K. A mouse model for an erythropoietin-deficiency anemia. Dis Model Mech. 2010;3:763-72 pubmed publisher
    In mammals, the production of red blood cells is tightly regulated by the growth factor erythropoietin (EPO)...
  4. Pugh C, Tan C, Jones R, Ratcliffe P. Functional analysis of an oxygen-regulated transcriptional enhancer lying 3' to the mouse erythropoietin gene. Proc Natl Acad Sci U S A. 1991;88:10553-7 pubmed
    b>Erythropoietin, the major hormone controlling red-cell production, is regulated in part through oxygen-dependent changes in the rate of transcription of its gene...
  5. Hagström L, Agbulut O, El Hasnaoui Saadani R, Marchant D, Favret F, Richalet J, et al. Epo is relevant neither for microvascular formation nor for the new formation and maintenance of mice skeletal muscle fibres in both normoxia and hypoxia. J Biomed Biotechnol. 2010;2010:137817 pubmed publisher
    b>Erythropoietin (Epo) and vascular growth factor (VEGF) are known to be involved in the regulation of cellular activity when oxygen transport is reduced as in anaemia or hypoxic conditions...
  6. Souma T, Yamazaki S, Moriguchi T, Suzuki N, Hirano I, Pan X, et al. Plasticity of renal erythropoietin-producing cells governs fibrosis. J Am Soc Nephrol. 2013;24:1599-616 pubmed publisher
    CKD progresses with fibrosis and erythropoietin (Epo)-dependent anemia, leading to increased cardiovascular complications, but the mechanisms linking Epo-dependent anemia and fibrosis remain unclear...
  7. Grimm C, Wenzel A, Stanescu D, Samardzija M, Hotop S, Groszer M, et al. Constitutive overexpression of human erythropoietin protects the mouse retina against induced but not inherited retinal degeneration. J Neurosci. 2004;24:5651-8 pubmed
    Elevation of erythropoietin (Epo) concentrations by hypoxic preconditioning or application of recombinant human Epo (huEpo) protects the mouse retina against light-induced degeneration by inhibiting photoreceptor cell apoptosis...
  8. Wagner K, Katschinski D, Hasegawa J, Schumacher D, Meller B, Gembruch U, et al. Chronic inborn erythrocytosis leads to cardiac dysfunction and premature death in mice overexpressing erythropoietin. Blood. 2001;97:536-42 pubmed
    The most common cause of an increase of the hematocrit is secondary to elevated erythropoietin levels. Erythrocytosis is assumed to cause higher blood viscosity that could put the cardiovascular system at hemodynamic and rheological risks...
  9. Minamishima Y, Kaelin W. Reactivation of hepatic EPO synthesis in mice after PHD loss. Science. 2010;329:407 pubmed publisher
    The kidney controls erythropoietin production in adults, and the anemia that can accompany renal failure is a major medical problem. The liver controls erythropoietin production during fetal life but is silenced shortly after birth...

More Information

Publications90

  1. Liu Y, Pop R, Sadegh C, Brugnara C, Haase V, Socolovsky M. Suppression of Fas-FasL coexpression by erythropoietin mediates erythroblast expansion during the erythropoietic stress response in vivo. Blood. 2006;108:123-33 pubmed
    b>Erythropoietin (Epo) is the principal regulator of the erythropoietic response to hypoxic stress, through its receptor, EpoR...
  2. Koury S, Bondurant M, Semenza G, Koury M. The use of in situ hybridization to study erythropoietin gene expression in murine kidney and liver. Microsc Res Tech. 1993;25:29-39 pubmed
    In situ hybridization has been used to localize erythropoietin (EPO)-producing cells in murine kidney and liver. Peritubular interstitial cells were the only cell type that produced EPO in the kidney...
  3. Chen Z, Asavaritikrai P, Prchal J, Noguchi C. Endogenous erythropoietin signaling is required for normal neural progenitor cell proliferation. J Biol Chem. 2007;282:25875-83 pubmed
    b>Erythropoietin (Epo) and its receptor (EpoR), critical for erythropoiesis, are expressed in the nervous system...
  4. Wu H, Liu X, Jaenisch R, Lodish H. Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor. Cell. 1995;83:59-67 pubmed
    b>Erythropoietin (EPO) is the principal growth factor regulating the production of circulating erythrocytes. We introduced null mutations into both Epo and the EPO receptor (EpoR) gene. Both heterozygotes appeared normal...
  5. Shoemaker C, Mitsock L. Murine erythropoietin gene: cloning, expression, and human gene homology. Mol Cell Biol. 1986;6:849-58 pubmed
    The gene for murine erythropoietin (EPO) was isolated from a mouse genomic library with a human EPO cDNA probe...
  6. Binley K, Askham Z, Iqball S, Spearman H, Martin L, de Alwis M, et al. Long-term reversal of chronic anemia using a hypoxia-regulated erythropoietin gene therapy. Blood. 2002;100:2406-13 pubmed
    ..Normally, red blood cell production is adjusted through the regulation of erythropoietin (Epo) production by the kidney...
  7. Gross A, Lodish H. Cellular trafficking and degradation of erythropoietin and novel erythropoiesis stimulating protein (NESP). J Biol Chem. 2006;281:2024-32 pubmed
    b>Erythropoietin (Epo) is essential for the production of mature red blood cells, and recombinant Epo is commonly used to treat anemia, but how Epo is degraded and cleared from the body is not understood...
  8. Obara N, Suzuki N, Kim K, Nagasawa T, Imagawa S, Yamamoto M. Repression via the GATA box is essential for tissue-specific erythropoietin gene expression. Blood. 2008;111:5223-32 pubmed publisher
    In response to anemia, erythropoietin (Epo) gene transcription is markedly induced in the kidney and liver...
  9. Grimm C, Wenzel A, Groszer M, Mayser H, Seeliger M, Samardzija M, et al. HIF-1-induced erythropoietin in the hypoxic retina protects against light-induced retinal degeneration. Nat Med. 2002;8:718-24 pubmed
    b>Erythropoietin (Epo) is upregulated by hypoxia and provides protection against apoptosis of erythroid progenitors in bone marrow and brain neurons...
  10. Rezaeian F, Wettstein R, Egger J, Sandmann F, Rücker M, Tobalem M, et al. Erythropoietin-induced upregulation of endothelial nitric oxide synthase but not vascular endothelial growth factor prevents musculocutaneous tissue from ischemic damage. Lab Invest. 2010;90:40-51 pubmed publisher
    Recent findings have attested the protective effects of erythropoietin (EPO) in ischemically challenged organs...
  11. Grenz A, Zhang H, Weingart J, von Wietersheim S, Eckle T, Schnermann J, et al. Lack of effect of extracellular adenosine generation and signaling on renal erythropoietin secretion during hypoxia. Am J Physiol Renal Physiol. 2007;293:F1501-11 pubmed
    ..to whether extracellular adenosine generation and signaling contributes to hypoxia-induced increases in renal erythropoietin (EPO) secretion...
  12. Sugiyama D, Kulkeaw K, Mizuochi C, Horio Y, Okayama S. Hepatoblasts comprise a niche for fetal liver erythropoiesis through cytokine production. Biochem Biophys Res Commun. 2011;410:301-6 pubmed publisher
    ..mRNA analysis suggested that Dlk-1-expressing hepatoblasts primarily expressed EPO and SCF, genes encoding erythropoietic cytokines...
  13. Suzuki N, Obara N, Pan X, Watanabe M, Jishage K, Minegishi N, et al. Specific contribution of the erythropoietin gene 3' enhancer to hepatic erythropoiesis after late embryonic stages. Mol Cell Biol. 2011;31:3896-905 pubmed publisher
    b>Erythropoietin (Epo) is secreted from the liver and kidney, where Epo production is strictly regulated at the transcriptional level in a hypoxia- and/or anemia-inducible manner...
  14. Brines M, Grasso G, Fiordaliso F, Sfacteria A, Ghezzi P, Fratelli M, et al. Erythropoietin mediates tissue protection through an erythropoietin and common beta-subunit heteroreceptor. Proc Natl Acad Sci U S A. 2004;101:14907-12 pubmed
    The cytokine erythropoietin (Epo) is tissue-protective in preclinical models of ischemic, traumatic, toxic, and inflammatory injuries...
  15. Lenox L, Perry J, Paulson R. BMP4 and Madh5 regulate the erythroid response to acute anemia. Blood. 2005;105:2741-8 pubmed
    ..These findings suggest a new model where stress erythroid progenitors, resident in the spleen, are poised to respond to changes in the microenvironment induced by acute anemia. ..
  16. Richmond T, Chohan M, Barber D. Turning cells red: signal transduction mediated by erythropoietin. Trends Cell Biol. 2005;15:146-55 pubmed
    b>Erythropoietin (EPO) is the crucial cytokine regulator of red blood-cell production...
  17. Shiozawa Y, Jung Y, Ziegler A, Pedersen E, Wang J, Wang Z, et al. Erythropoietin couples hematopoiesis with bone formation. PLoS ONE. 2010;5:e10853 pubmed publisher
    ..Yet, what stimulates HSCs to produce BMPs is unclear. In this study, we demonstrate that erythropoietin (Epo) activates Jak-Stat signaling pathways in HSCs which leads to the production of BMPs...
  18. Rankin E, Biju M, Liu Q, Unger T, Rha J, Johnson R, et al. Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo. J Clin Invest. 2007;117:1068-77 pubmed
    Erythropoiesis is critically dependent on erythropoietin (EPO), a glycoprotein hormone that is regulated by hypoxia-inducible factor (HIF)...
  19. El Hasnaoui Saadani R, Pichon A, Marchant D, Olivier P, Launay T, Quidu P, et al. Cerebral adaptations to chronic anemia in a model of erythropoietin-deficient mice exposed to hypoxia. Am J Physiol Regul Integr Comp Physiol. 2009;296:R801-11 pubmed publisher
    ..These studies were done in erythropoietin-deficient mice (Epo-TAg(h)) in normoxia and following acute (one day) and chronic (14 days, barometric ..
  20. Tsai P, Ohab J, Kertesz N, Groszer M, Matter C, Gao J, et al. A critical role of erythropoietin receptor in neurogenesis and post-stroke recovery. J Neurosci. 2006;26:1269-74 pubmed
    b>Erythropoietin (EPO) is the principal growth factor regulating the production of red blood cells. Recent studies demonstrated that exogenous EPO acts as a neuroprotectant and regulates neurogenesis...
  21. Kertesz N, Wu J, Chen T, Sucov H, Wu H. The role of erythropoietin in regulating angiogenesis. Dev Biol. 2004;276:101-10 pubmed
    b>Erythropoietin (EPO) is an essential growth factor that regulates erythrocyte production in mammals. In this study, we demonstrate a novel role of EPO in regulating angiogenesis in vivo...
  22. Tamai Y, Nakajima R, Ishikawa T, Takaku K, Seldin M, Taketo M. Colonic hamartoma development by anomalous duplication in Cdx2 knockout mice. Cancer Res. 1999;59:2965-70 pubmed
  23. Macias M, Welch K, Denzler K, Larson K, Lee N, Lee J. Identification of a new murine eosinophil major basic protein (mMBP) gene: cloning and characterization of mMBP-2. J Leukoc Biol. 2000;67:567-76 pubmed
    ..Moreover, using mMBP-1 knockout mice and immunohistochemistry with an antisera that recognizes both mMBP-1 and -2, we demonstrate that mMBP-2 protein expression is restricted to eosinophil lineage-committed cells. ..
  24. Chhabra A, Lechner A, Ueno M, Acharya A, Van Handel B, Wang Y, et al. Trophoblasts regulate the placental hematopoietic niche through PDGF-B signaling. Dev Cell. 2012;22:651-9 pubmed publisher
    ..to a requirement of PDGF-B signaling in hematopoietic cells but rather in placental trophoblasts, which upregulated Epo in the absence of PDGF-B signaling...
  25. Forand A, Beck L, Leroy C, Rousseau A, Boitez V, Cohen I, et al. EKLF-driven PIT1 expression is critical for mouse erythroid maturation in vivo and in vitro. Blood. 2013;121:666-78 pubmed publisher
    ..This is the first demonstration of a physiologic involvement of PIT1 in erythroid maturation in vivo. ..
  26. Makita T, Duncan S, Sucov H. Retinoic acid, hypoxia, and GATA factors cooperatively control the onset of fetal liver erythropoietin expression and erythropoietic differentiation. Dev Biol. 2005;280:59-72 pubmed
    The cytokine erythropoietin (Epo) is an essential factor promoting the survival, proliferation, and differentiation of erythroid progenitor cells...
  27. Lee H, Young W, Shih C, Chang C. Suppression of the human erythropoietin gene expression by the TR2 orphan receptor, a member of the steroid receptor superfamily. J Biol Chem. 1996;271:10405-12 pubmed
    ..5'-TCTGACCTCTCGACCTAC-3') has been identified in the 3-minimal hypoxia-inducible enhancer of the human erythropoietin gene for the TR2 orphan receptor, an androgen-repressed transcription factor and a member of the steroid/..
  28. Suzuki N, Mukai H, Yamamoto M. In vivo regulation of erythropoiesis by chemically inducible dimerization of the erythropoietin receptor intracellular domain. PLoS ONE. 2015;10:e0119442 pubmed publisher
    b>Erythropoietin (Epo) and its receptor (EpoR) are required for the regulation of erythropoiesis...
  29. Fantin V, Lavan B, Wang Q, Jenkins N, Gilbert D, Copeland N, et al. Cloning, tissue expression, and chromosomal location of the mouse insulin receptor substrate 4 gene. Endocrinology. 1999;140:1329-37 pubmed
    ..As the mouse genes for IRS-1 and -2 are on chromosomes 1 and 8, respectively, each IRS gene resides on a different chromosome. ..
  30. Mastrogiannaki M, Matak P, Mathieu J, Delga S, Mayeux P, Vaulont S, et al. Hepatic hypoxia-inducible factor-2 down-regulates hepcidin expression in mice through an erythropoietin-mediated increase in erythropoiesis. Haematologica. 2012;97:827-34 pubmed publisher
    ..mice were fed an iron-deficient diet for 2 months and Vhlh/Hif1a knockout mice were treated with neutralizing erythropoietin antibody...
  31. Mille Hamard L, Billat V, Henry E, Bonnamy B, Joly F, Benech P, et al. Skeletal muscle alterations and exercise performance decrease in erythropoietin-deficient mice: a comparative study. BMC Med Genomics. 2012;5:29 pubmed publisher
    b>Erythropoietin (EPO) is known to improve exercise performance by increasing oxygen blood transport and thus inducing a higher maximum oxygen uptake (VO2max)...
  32. Liu Y, Lu X, Xiang F, Poelmann R, Gittenberger de Groot A, Robbins J, et al. Nitric oxide synthase-3 deficiency results in hypoplastic coronary arteries and postnatal myocardial infarction. Eur Heart J. 2014;35:920-31 pubmed publisher
    ..expression of Gata4, Wilms tumour-1, vascular endothelial growth factor, basic fibroblast growth factor and erythropoietin, and inhibited migration of epicardial cells...
  33. Beru N, McDonald J, Goldwasser E. Activation of the erythropoietin gene due to the proximity of an expressed gene. DNA. 1989;8:253-9 pubmed
    The erythroleukemic cell line IW32 has a normal erythropoietin (epo) gene and one which has undergone rearrangement and amplification...
  34. Abutin R, Chen J, Lung T, Lloyd J, Sawyer S, Harada H. Erythropoietin-induced phosphorylation/degradation of BIM contributes to survival of erythroid cells. Exp Hematol. 2009;37:151-8 pubmed publisher
    ..We investigated here the role of BIM in erythropoietin (EPO)-mediated survival in erythroid cells.
  35. Mowat F, Gonzalez F, Luhmann U, Lange C, Duran Y, Smith A, et al. Endogenous erythropoietin protects neuroretinal function in ischemic retinopathy. Am J Pathol. 2012;180:1726-39 pubmed publisher
    ..function and survival in murine oxygen-induced retinopathy (OIR) and to define the role of endogenous erythropoietin (EPO) in this model...
  36. Urrutia A, Afzal A, Nelson J, Davidoff O, Gross K, Haase V. Prolyl-4-hydroxylase 2 and 3 coregulate murine erythropoietin in brain pericytes. Blood. 2016;128:2550-2560 pubmed
    ..is the increased production of red blood cells due to hypoxia-inducible factor (HIF)-mediated induction of erythropoietin (EPO)...
  37. Serikawa T, Montagutelli X, Simon Chazottes D, Guenet J. Polymorphisms revealed by PCR with single, short-sized, arbitrary primers are reliable markers for mouse and rat gene mapping. Mamm Genome. 1992;3:65-72 pubmed
    ..From these experiments we conclude that, under precisely standardized PCR conditions, the DNA molecules amplified with these arbitrarily designed primers are useful and reliable markers for genetic mapping in both mouse and rat. ..
  38. Ehrenreich H, Hasselblatt M, Knerlich F, von Ahsen N, Jacob S, Sperling S, et al. A hematopoietic growth factor, thrombopoietin, has a proapoptotic role in the brain. Proc Natl Acad Sci U S A. 2005;102:862-7 pubmed
    ..We report that thrombopoietin (TPO), a stimulator of platelet formation, acts in the brain as a counterpart of erythropoietin (EPO), a hematopoietic growth factor with neuroprotective properties...
  39. Lacombe C, Tambourin P, Mattei M, Simon D, Guenet J. The murine erythropoietin gene is localized on chromosome 5. Blood. 1988;72:1440-2 pubmed
  40. Takaki S, Watts J, Forbush K, Nguyen N, Hayashi J, Alberola Ila J, et al. Characterization of Lnk. An adaptor protein expressed in lymphocytes. J Biol Chem. 1997;272:14562-70 pubmed
    ..Together these studies suggest that Lnk participates in signaling from receptors other than antigen receptors in lymphocytes. ..
  41. Baig S, Patel Y, Coussons P, Grant R. Erythropoietin and interleukin-1beta modulate nitrite production in a Swiss 3T3 cell model of rheumatoid synovial fibroblasts. Biochem Soc Trans. 2002;30:883-6 pubmed
    b>Erythropoietin (EPO), a haemopoietic growth factor and a primary regulator of erythropoiesis, is widely used to treat anaemia in various chronic complications of rheumatoid arthritis (RA)...
  42. Lee R, Kertesz N, Joseph S, Jegalian A, Wu H. Erythropoietin (Epo) and EpoR expression and 2 waves of erythropoiesis. Blood. 2001;98:1408-15 pubmed
    ..In this study, it is proposed that erythropoietin (Epo) expression and the resultant EpoR activation regulate the timing of the definitive wave...
  43. Vilalta A, Wu D, Margalith M, Hobart P. Rabbit EPO gene and cDNA: expression of rabbit EPO after intramuscular injection of pDNA. Biochem Biophys Res Commun. 2001;284:823-7 pubmed
    b>Erythropoietin (EPO) cDNA was cloned from kidney total RNA of a NZW rabbit. The cDNA comprises a 588-bp open reading frame encoding a 195 amino acid protein with distinguishable regions of high of homology to other mammalian EPOs...
  44. Funakoshi A, Muta H, Baba T, Shimizu S. Gene expression of mutant erythropoietin in hepatocellular carcinoma. Biochem Biophys Res Commun. 1993;195:717-22 pubmed
    ..of hepatocellular carcinoma complicated by erythrocytosis showed an increased level of serum immunoreactive erythropoietin (EPO) and EPO bioactivity...
  45. Burrill D, Vernet A, Collins J, Silver P, Way J. Targeted erythropoietin selectively stimulates red blood cell expansion in vivo. Proc Natl Acad Sci U S A. 2016;113:5245-50 pubmed publisher
    ..Here we applied this approach in vivo to the anemia drug erythropoietin (EPO), to direct its activity to EPO receptors (EPO-Rs) on red blood cell (RBC) precursors and prevent ..
  46. Mason Garcia M, Harlan R, Mallia C, Jeter J, Steinberg H, Fermin C, et al. Interleukin-3 or erythropoietin induced nuclear localization of protein kinase C beta isoforms in hematopoietic target cells. Cell Prolif. 1995;28:145-55 pubmed
    ..been implicated in the signal transduction pathways for the biological effect of both interleukin-3 (IL-3) and erythropoietin (EPO) in hematopoietic target cells...
  47. Macarlupú J, Buvry A, Morel O, Leon Velarde F, Richalet J, Favret F. Characterisation of the ventilatory response to hypoxia in a model of transgenic anemic mice. Respir Physiol Neurobiol. 2006;150:19-26 pubmed
    ..These mice have a targeted disruption in the 5' untranslated region of the Epo gene that reduces Epo expression such that the homozygous animal is severely anemic...
  48. Colella P, Iodice C, Di Vicino U, Annunziata I, Surace E, Auricchio A. Non-erythropoietic erythropoietin derivatives protect from light-induced and genetic photoreceptor degeneration. Hum Mol Genet. 2011;20:2251-62 pubmed publisher
    ..In addition to its erythropoietic activity, erythropoietin (EPO) presents neurotrophic characteristics...
  49. Duncan S. Transcriptional regulation of liver development. Dev Dyn. 2000;219:131-42 pubmed
    ..The picture that emerges is that specific transcription factors use novel mechanisms to orchestrate changes in gene expression patterns that ultimately direct cell differentiation. ..
  50. Carraway M, Suliman H, Jones W, Chen C, Babiker A, Piantadosi C. Erythropoietin activates mitochondrial biogenesis and couples red cell mass to mitochondrial mass in the heart. Circ Res. 2010;106:1722-30 pubmed publisher
    b>Erythropoietin (EPO) is often administered to cardiac patients with anemia, particularly from chronic kidney disease, and stimulation of erythropoiesis may stabilize left ventricular and renal function by recruiting protective effects ..
  51. Wu H, Lee S, Gao J, Liu X, Iruela Arispe M. Inactivation of erythropoietin leads to defects in cardiac morphogenesis. Development. 1999;126:3597-605 pubmed
    b>Erythropoietin is an essential growth factor that promotes survival, proliferation, and differentiation of mammalian erythroid progenitor cells...
  52. Chowdhury K, Goulding M, Walther C, Imai K, Fickenscher H. The ubiquitous transactivator Zfp-38 is upregulated during spermatogenesis with differential transcription. Mech Dev. 1992;39:129-42 pubmed
    ..The presence of both a transcriptional activating domain and 7 DNA binding zinc fingers, coupled with the cell type(s) specific expression pattern, suggests that Zfp-38 has the potential to regulate transcription during spermatogenesis. ..
  53. Zelko I, Folz R. Extracellular superoxide dismutase functions as a major repressor of hypoxia-induced erythropoietin gene expression. Endocrinology. 2005;146:332-40 pubmed
    ..extracellular superoxide dismutase (EC-SOD) plays a major role in regulating the magnitude of hypoxia-induced erythropoietin (Epo) gene expression, thus implicating superoxide as an intermediary signal transduction molecule critical to ..
  54. Asada N, Takase M, Nakamura J, Oguchi A, Asada M, Suzuki N, et al. Dysfunction of fibroblasts of extrarenal origin underlies renal fibrosis and renal anemia in mice. J Clin Invest. 2011;121:3981-90 pubmed publisher
    ..of myofibroblasts, whereas renal anemia is mediated by the reduced production of fibroblast-derived erythropoietin, a hormone that stimulates erythropoiesis...
  55. Perez Jurado L, Wang Y, Francke U, Cruces J. TBL2, a novel transducin family member in the WBS deletion: characterization of the complete sequence, genomic structure, transcriptional variants and the mouse ortholog. Cytogenet Cell Genet. 1999;86:277-84 pubmed
    ..23. Since haploinsufficiency has been shown for other WD-repeat containing proteins, hemizygosity of TBL2 may contribute to some of the aspects of the complex WBS phenotype. ..
  56. Ruschitzka F, Wenger R, Stallmach T, Quaschning T, de Wit C, Wagner K, et al. Nitric oxide prevents cardiovascular disease and determines survival in polyglobulic mice overexpressing erythropoietin. Proc Natl Acad Sci U S A. 2000;97:11609-13 pubmed
    ..effects of NO in preventing vascular disease in vivo, we generated transgenic mice overexpressing human erythropoietin. These animals induce polyglobulia known to be associated with a high incidence of vascular disease...
  57. Suliman H, Ali M, Piantadosi C. Superoxide dismutase-3 promotes full expression of the EPO response to hypoxia. Blood. 2004;104:43-50 pubmed
    ..To investigate the function of renal SOD3, we colocalized it with erythropoietin (EPO) to proximal tubules using in situ hybridization and immunohistochemistry...
  58. Wang L, Jia Y, Rogers H, Wu Y, Huang S, Noguchi C. GATA-binding protein 4 (GATA-4) and T-cell acute leukemia 1 (TAL1) regulate myogenic differentiation and erythropoietin response via cross-talk with Sirtuin1 (Sirt1). J Biol Chem. 2012;287:30157-69 pubmed publisher
    b>Erythropoietin (EPO), the cytokine required for erythrocyte production, contributes to muscle progenitor cell proliferation and delay myogenic differentiation. However, the underlying mechanism is not yet fully understood...
  59. Digicaylioglu M, Bichet S, Marti H, Wenger R, Rivas L, Bauer C, et al. Localization of specific erythropoietin binding sites in defined areas of the mouse brain. Proc Natl Acad Sci U S A. 1995;92:3717-20 pubmed
    The main physiological regulator of erythropoiesis is the hematopoietic growth factor erythropoietin (EPO), which is induced in response to hypoxia...
  60. Miró Murillo M, Elorza A, Soro Arnaiz I, Albacete Albacete L, Ordoñez A, Balsa E, et al. Acute Vhl gene inactivation induces cardiac HIF-dependent erythropoietin gene expression. PLoS ONE. 2011;6:e22589 pubmed publisher
    ..rapidly resulted in a marked splenomegaly and skin erythema, accompanied by renal and hepatic induction of the erythropoietin (Epo) gene, indicative of the in vivo activation of the oxygen sensing HIF pathway...
  61. Zhdanov V, Miroshnichenko L, Udut E, Zyuz kov G, Khrichkova T, Simanina E, et al. Role of PI3K, MAPK/ERK 1/2, and p38 in Production of Erythropoietic Activity by Bone Marrow Cells after Blood Loss. Bull Exp Biol Med. 2016;162:51-55 pubmed
    ..b>Erythropoietin is not the decisive factor in the formation of erythropoietic activity of adherent cells...
  62. Jiang X, Gao M, Chen Y, Liu J, Qi S, Ma J, et al. EPO-dependent induction of erythroferrone drives hepcidin suppression and systematic iron absorption under phenylhydrazine-induced hemolytic anemia. Blood Cells Mol Dis. 2016;58:45-51 pubmed publisher
    ..We found that serum erythropoietin (EPO) concentration was dramatically elevated by nearly 5000-fold for the first 2days, and then drop to the ..
  63. Ploemacher R, van Soest P, Boudewijn A, Neben S. Interleukin-12 enhances interleukin-3 dependent multilineage hematopoietic colony formation stimulated by interleukin-11 or steel factor. Leukemia. 1993;7:1374-80 pubmed
    ..stem cells using a semi-solid culture assay in the absence or presence of IL-3, IL-11, Steel factor (SF) and erythropoietin. IL-12 did not support colony formation as a single factor, nor in the presence of IL-11 or SF...
  64. Ito T, Arimitsu N, Takeuchi M, Kawamura N, Nagata M, Saso K, et al. Transcription elongation factor S-II is required for definitive hematopoiesis. Mol Cell Biol. 2006;26:3194-203 pubmed
    ..Thus, S-II has critical and nonredundant roles in definitive hematopoiesis. ..
  65. Hagström L, Canon F, Agbulut O, Marchant D, Serrurier B, Richalet J, et al. Skeletal muscle intrinsic functional properties are preserved in a model of erythropoietin deficient mice exposed to hypoxia. Pflugers Arch. 2010;459:713-23 pubmed publisher
    b>Erythropoietin (Epo)-induced polycythemia is the main factor of adaptation to hypoxia...
  66. Mansouri A, Yokota Y, Wehr R, Copeland N, Jenkins N, Gruss P. Paired-related murine homeobox gene expressed in the developing sclerotome, kidney, and nervous system. Dev Dyn. 1997;210:53-65 pubmed
    ..The temporal and spatial expression pattern suggests that Uncx4.1 may play an important role in kidney development and in the differentiation of the sclerotome and the nervous system. ..
  67. Yeo E, Cho Y, Kim M, Park J. Contribution of HIF-1alpha or HIF-2alpha to erythropoietin expression: in vivo evidence based on chromatin immunoprecipitation. Ann Hematol. 2008;87:11-7 pubmed
    Circulating erythropoietin (EPO) is mainly produced by the kidneys and mediates erythrogenesis in bone marrow and nonhematopoietic cell survival. EPO is also produced in other tissues where it functions as a paracrine...
  68. Bill R, Winter P, McHale C, Hodges V, Elder G, Caley J, et al. Expression and mutagenesis of recombinant human and murine erythropoietins in Escherichia coli. Biochim Biophys Acta. 1995;1261:35-43 pubmed
    Expression of the polypeptide hormone erythropoietin (EPO) in Escherichia coli by four bacterial expression vectors was examined...
  69. Gurruchaga H, Ciriza J, Saenz del Burgo L, Rodríguez Madoz J, Santos E, Prosper F, et al. Cryopreservation of microencapsulated murine mesenchymal stem cells genetically engineered to secrete erythropoietin. Int J Pharm. 2015;485:15-24 pubmed publisher
    ..stem cells, the penetrating cryoprotectant DMSO at a concentration of 10% displayed the best viability and erythropoietin secretion profile compared to the other cryoprotectant solutions...
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    ..interstitial fibroblast-like cells are critical for adult erythropoiesis, as they are the main source of erythropoietin (EPO)...
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    ..The gene for zonadhesin maps to chromosome 5 in the mouse (Zan) and to chromosome 7 in the human (ZAN) in a position near the gene for the egg extracellular matrix protein ZP3. ..
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    ..Here we found that find-me signal sphingosine 1-phosphate (S1P) activated macrophage erythropoietin (EPO) signaling promoted apoptotic cell clearance and immune tolerance...
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    ..IW32, derived by transformation with the Friend murine leukemia virus, has been shown previously to produce erythropoietin (EPO) constitutively...
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    Eight mouse gene loci (Atp1b2, Epo, Kit, Krt2, Mor1, Ren1, Pdgfb, and Wnt1) that contain unidentified microsatellites were selected to detect simple sequence-length polymorphisms on genomic DNAs from two laboratory strains (C57BL/6J and ..
  75. Chen W, Gu P, Jiang X, Ruan H, Li C, Gao X. Protein phosphatase 2A catalytic subunit ? (PP2Ac?) maintains survival of committed erythroid cells in fetal liver erythropoiesis through the STAT5 pathway. Am J Pathol. 2011;178:2333-43 pubmed publisher
    ..Collectively, these data provide direct loss-of-function evidence demonstrating the importance of PP2Ac? for the survival of committed erythroid cells during fetal liver erythropoiesis...
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    ..The physical linkage is also evidenced in mouse, where the two genes appear to lie within a 350 kb Mlu I fragment, on mouse chromosome 5. ..
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  78. Bach I, Galcheva Gargova Z, Mattei M, Simon Chazottes D, Guenet J, Cereghini S, et al. Cloning of human hepatic nuclear factor 1 (HNF1) and chromosomal localization of its gene in man and mouse. Genomics. 1990;8:155-64 pubmed
    ..3 and 5F in human and mouse, respectively, establishing a new segmental homology between these two chromosomes. ..
  79. Chang K, Tam M, Stevenson M. Modulation of the course and outcome of blood-stage malaria by erythropoietin-induced reticulocytosis. J Infect Dis. 2004;189:735-43 pubmed
    Severe anemia is a major life-threatening complication of malaria. The roles of erythropoietin (Epo) and erythropoiesis during blood-stage malaria were investigated...
  80. Zhao Q, Chang C, Gonzalez J, Alzahrani K, Button J, Fraidenraich D. Combined Id1 and Id3 Deletion Leads to Severe Erythropoietic Disturbances. PLoS ONE. 2016;11:e0154480 pubmed publisher
    ..Together, these findings demonstrate that loss of Id compensation leads to dysregulation of the hematopoietic transcriptional network and multiple defects in erythropoietic development in adult mice. ..
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    We purposed to determine the impact of erythropoietin on altering glucose metabolism in the settings of in vitro and in vivo experiments...