Gene Symbol: epigen
Description: epithelial mitogen
Alias: 2310069M11Rik, epigen, epigen, EPG
Species: mouse
Products:     epigen

Top Publications

  1. Sahin U, Blobel C. Ectodomain shedding of the EGF-receptor ligand epigen is mediated by ADAM17. FEBS Lett. 2007;581:41-4 pubmed
    ..EGFR-ligands, yet little is known about the enzyme responsible for processing the recently identified EGFR ligand, epigen. Here we show that ectodomain shedding of epigen requires ADAM17, which can be stimulated by phorbol esters, ..
  2. Lin M, Chang K, Lin S, Miner J. Epidermal hyperproliferation in mice lacking fatty acid transport protein 4 (FATP4) involves ectopic EGF receptor and STAT3 signaling. Dev Biol. 2010;344:707-19 pubmed publisher
    ..These findings have important implications for understanding the pathogenesis of ichthyosis prematurity syndrome, a disease recently shown to be caused by FATP4 mutations. ..
  3. Maier H, Meixner M, Hartmann D, Sandhoff R, Wang Eckhardt L, Zöller I, et al. Normal fur development and sebum production depends on fatty acid 2-hydroxylase expression in sebaceous glands. J Biol Chem. 2011;286:25922-34 pubmed publisher
    ..This was accompanied by a significant up-regulation of the epidermal growth factor receptor ligand epigen in sebocytes...
  4. Strachan L, Murison J, Prestidge R, Sleeman M, Watson J, Kumble K. Cloning and biological activity of epigen, a novel member of the epidermal growth factor superfamily. J Biol Chem. 2001;276:18265-71 pubmed
    ..We have named the protein encoded by this expressed sequence tag Epigen, for epithelial mitogen...
  5. Johnson K, Lane P, Cook S, Harris B, Ward Bailey P, Bronson R, et al. Curly bare (cub), a new mouse mutation on chromosome 11 causing skin and hair abnormalities, and a modifier gene (mcub) on chromosome 5. Genomics. 2003;81:6-14 pubmed
    ..The similarity of the wavy coat phenotype to those of Tgfa and Egfr mutations and the map positions of cub and mcub suggest candidate genes that interact in the EGF receptor signal transduction pathway. ..
  6. Kochupurakkal B, Harari D, Di Segni A, Maik Rachline G, Lyass L, Gur G, et al. Epigen, the last ligand of ErbB receptors, reveals intricate relationships between affinity and mitogenicity. J Biol Chem. 2005;280:8503-12 pubmed
    ..These searches reidentified all known EGF-like growth factors including Epigen (EPG), the least characterized ligand, but failed to identify novel factors...
  7. Ling S, Chang X, Schultz L, Lee T, Chaux A, Marchionni L, et al. An EGFR-ERK-SOX9 signaling cascade links urothelial development and regeneration to cancer. Cancer Res. 2011;71:3812-21 pubmed publisher
    ..These results identify a novel, potentially oncogenic signaling axis linking urothelial injury to UroCa. Inhibiting this axis is feasible through a variety of pharmacologic approaches and may have clinical utility...
  8. Dahlhoff M, Schafer M, Wolf E, Schneider M. Genetic deletion of the EGFR ligand epigen does not affect mouse embryonic development and tissue homeostasis. Exp Cell Res. 2013;319:529-35 pubmed publisher
    ..experiments clarified the biological function of all family members except for the last characterized ligand, epigen. We employed gene targeting in mouse embryonic stem cells to generate mice lacking epigen expression...
  9. Hosur V, Johnson K, Burzenski L, Stearns T, Maser R, Shultz L. Rhbdf2 mutations increase its protein stability and drive EGFR hyperactivation through enhanced secretion of amphiregulin. Proc Natl Acad Sci U S A. 2014;111:E2200-9 pubmed publisher
    ..This work underscores the physiological prominence of iRhom2 in controlling EGFR signaling events involved in wound healing and neoplastic growth, and yields insight into the function of key iRhom2 domains. ..

More Information


  1. Dahlhoff M, Frances D, Kloepper J, Paus R, Schafer M, Niemann C, et al. Overexpression of epigen during embryonic development induces reversible, epidermal growth factor receptor-dependent sebaceous gland hyperplasia. Mol Cell Biol. 2014;34:3086-95 pubmed publisher
    ..In this study, using a transgenic mouse line with tissue-specific and inducible expression of the EGFR ligand epigen, we showed that increased activation of the EGFR in skin keratinocytes results in enlarged SGs and increased sebum ..