epididymal retinoic acid binding protein


Gene Symbol: epididymal retinoic acid binding protein
Description: lipocalin 5
Alias: E-RABP, Erabp, MEP10, epididymal-specific lipocalin-5, epididymal retinoic acid binding protein, epididymal secretory protein 10, lcn5
Species: mouse

Top Publications

  1. Rankin T, Tsuruta K, Holland M, Griswold M, Orgebin Crist M. Isolation, immunolocalization, and sperm-association of three proteins of 18, 25, and 29 kilodaltons secreted by the mouse epididymis. Biol Reprod. 1992;46:747-66 pubmed
    ..The related rat protein migrated at approximately 20 kDa. Amino acid sequence analysis of MEP 10 revealed an 86% sequence similarity with rat proteins B and C.(ABSTRACT TRUNCATED AT 400 WORDS) ..
  2. Zhang Y, Zhao Y, Huang J. Retinoid-binding proteins: similar protein architectures bind similar ligands via completely different ways. PLoS ONE. 2012;7:e36772 pubmed publisher
    ..Plasma retinol-binding protein (RBP) and epididymal retinoic acid binding protein (ERABP) carry retinoids in bodily fluids, while cellular retinol-binding proteins (CRBPs) and ..
  3. Lareyre J, Mattei M, Kasper S, Ong D, Matusik R, Orgebin Crist M. Genomic organization and chromosomal localization of the murine epididymal retinoic acid-binding protein (mE-RABP) gene. Mol Reprod Dev. 1998;50:387-95 pubmed
    ..Our data, combined with that of others, suggest that the proximal segment of the mouse chromosome 2 may be a rich region for genes encoding lipocalins with a genomic organization highly related to the mE-RABP gene. ..
  4. Rankin T, Ong D, Orgebin Crist M. The 18-kDa mouse epididymal protein (MEP 10) binds retinoic acid. Biol Reprod. 1992;46:767-71 pubmed
    ..Similar ligand specificity has also been described for the rat proteins B and C by Ong and Chytil [Arch Biochem Biophys' 1988; 267:474-478].(ABSTRACT TRUNCATED AT 250 WORDS) ..
  5. Suzuki K, Yu X, Chaurand P, Araki Y, Lareyre J, Caprioli R, et al. Epididymis-specific lipocalin promoters. Asian J Androl. 2007;9:515-21 pubmed
    ..These are differently regulated and regionalized in the epididymis. Lipocalin 5 (Lcn5 or mE-RABP) and Lipocalin 8 (Lcn8 or mEP17) are homologous genes belonging to the epididymis-specific lipocalin ..
  6. Suzuki K, Yu X, Chaurand P, Araki Y, Lareyre J, Caprioli R, et al. Epididymis-specific promoter-driven gene targeting: a transcription factor which regulates epididymis-specific gene expression. Mol Cell Endocrinol. 2006;250:184-9 pubmed
    ..Lipocalin 5 [Lcn5 or epididymal retinoic acid-binding protein (E-RABP)] is a member of this epididymis-specific lipocalin gene ..
  7. Ong D, Newcomer M, Lareyre J, Orgebin Crist M. Epididymal retinoic acid-binding protein. Biochim Biophys Acta. 2000;1482:209-17 pubmed
  8. Salier J. Chromosomal location, exon/intron organization and evolution of lipocalin genes. Biochim Biophys Acta. 2000;1482:25-34 pubmed
  9. Li H, Tago K, Io K, Kuroiwa K, Arai T, Iwahana H, et al. The cloning and nucleotide sequence of human ST2L cDNA. Genomics. 2000;67:284-90 pubmed
    ..We also established stable transfectants of a human glioblastoma cell line, T98G, that express human ST2L constitutively, and we confirmed cell-surface expression of human ST2L protein on the transfectants. ..

More Information


  1. Lareyre J, Thomas T, Zheng W, Kasper S, Ong D, Orgebin Crist M, et al. A 5-kilobase pair promoter fragment of the murine epididymal retinoic acid-binding protein gene drives the tissue-specific, cell-specific, and androgen-regulated expression of a foreign gene in the epididymis of transgenic mice. J Biol Chem. 1999;274:8282-90 pubmed
    ..Altogether, our results demonstrate that the 5-kb promoter fragment of the mE-RABP gene contains all of the information required for the hormonal regulation and the spatial and temporal expression of the mE-RABP gene in the epididymis. ..
  2. Lareyre J, Zheng W, Zhao G, Kasper S, Newcomer M, Matusik R, et al. Molecular cloning and hormonal regulation of a murine epididymal retinoic acid-binding protein messenger ribonucleic acid. Endocrinology. 1998;139:2971-81 pubmed
    ..secretory protein MEP 10 (mouse epididymal protein 10) was cloned and is now renamed murine epididymal retinoic acid binding protein (mE-RABP)...
  3. Pattanayek R, Newcomer M. Protein and ligand adaptation in a retinoic acid binding protein. Protein Sci. 1999;8:2027-32 pubmed
    A retinoic acid binding protein isolated from the lumen of the rat epididymis (ERABP) is a member of the lipocalin superfamily...
  4. Lareyre J, Reid K, Nelson C, Kasper S, Rennie P, Orgebin Crist M, et al. Characterization of an androgen-specific response region within the 5' flanking region of the murine epididymal retinoic acid binding protein gene. Biol Reprod. 2000;63:1881-92 pubmed
    ..In conclusion, the mE-RABP ARR is a good model for the study of molecular mechanisms that lead to an androgen-specific responsiveness in vivo. ..
  5. Lareyre J, Winfrey V, Kasper S, Ong D, Matusik R, Olson G, et al. Gene duplication gives rise to a new 17-kilodalton lipocalin that shows epididymal region-specific expression and testicular factor(s) regulation. Endocrinology. 2001;142:1296-308 pubmed
    ..Together our results suggest that mE-RABP and mEP17 genes were generated by duplication and that evolution led to a different region-specific gene expression and regulation in the epididymis. ..
  6. Sundaram M, van Aalten D, Findlay J, Sivaprasadarao A. The transfer of transthyretin and receptor-binding properties from the plasma retinol-binding protein to the epididymal retinoic acid-binding protein. Biochem J. 2002;362:265-71 pubmed
    ..retinol-binding protein (RBP) and its close structural homologue the epididymal retinoic acid-binding protein (ERABP)...
  7. Chaurand P, Fouch├ęcourt S, DaGue B, Xu B, Reyzer M, Orgebin Crist M, et al. Profiling and imaging proteins in the mouse epididymis by imaging mass spectrometry. Proteomics. 2003;3:2221-39 pubmed
    ..Furthermore, from the signal intensities observed in the different protein profiles organized in space, semiquantitative information for each protein was obtained. ..
  8. Suzuki K, Lareyre J, Sanchez D, Gutierrez G, Araki Y, Matusik R, et al. Molecular evolution of epididymal lipocalin genes localized on mouse chromosome 2. Gene. 2004;339:49-59 pubmed
    We previously identified two murine secretory proteins, mE-RABP(Lcn5) and mEP17(Lcn8), belonging to the lipocalin family and specifically expressed in the epididymis. The genes are contiguous and localized on mouse chromosome 2...
  9. Yu X, Gupta A, Wang Y, Suzuki K, Mirosevich J, Orgebin Crist M, et al. Foxa1 and Foxa2 interact with the androgen receptor to regulate prostate and epididymal genes differentially. Ann N Y Acad Sci. 2005;1061:77-93 pubmed
    ..Further, Foxa2 interacts with the AR to regulate the mouse epididymal retinoic acid binding protein (mE-RABP) gene, an epididymis-specific gene...
  10. Yu X, Suzuki K, Wang Y, Gupta A, Jin R, Orgebin Crist M, et al. The role of forkhead box A2 to restrict androgen-regulated gene expression of lipocalin 5 in the mouse epididymis. Mol Endocrinol. 2006;20:2418-31 pubmed
    Murine epididymal retinoic acid-binding protein [or lipocalin 5 (Lcn5)] is synthesized and secreted by the principal cells of the mouse middle/distal caput epididymidis...
  11. Vreeburg J, Holland M, Cornwall G, Orgebin Crist M. Secretion and transport of mouse epididymal proteins after injection of 35S-methionine. Biol Reprod. 1990;43:113-20 pubmed
    ..Five days after injection, the three proteins were found in Regions 4 and 5. However, the 25-kDa protein was present in reduced amount, whereas the 18- and 29-kDa proteins accumulated in caudal fluid.(ABSTRACT TRUNCATED AT 250 WORDS) ..