epididymal retinoic acid binding protein

Summary

Gene Symbol: epididymal retinoic acid binding protein
Description: lipocalin 5
Alias: E-RABP, Erabp, MEP10, epididymal retinoic acid binding protein, epididymal secretory protein 10, epididymal-specific lipocalin-5, lcn5
Species: mouse

Top Publications

  1. pmc Retinoid-binding proteins: similar protein architectures bind similar ligands via completely different ways
    Yu Ru Zhang
    State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China
    PLoS ONE 7:e36772. 2012
  2. ncbi Epididymis-specific lipocalin promoters
    Kichiya Suzuki
    Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    Asian J Androl 9:515-21. 2007
  3. pmc The transfer of transthyretin and receptor-binding properties from the plasma retinol-binding protein to the epididymal retinoic acid-binding protein
    Manickavasagam Sundaram
    School of Biochemistry and Molecular Biology, University of Leeds, Leeds LS2 9JT, UK
    Biochem J 362:265-71. 2002
  4. ncbi Foxa1 and Foxa2 interact with the androgen receptor to regulate prostate and epididymal genes differentially
    Xiuping Yu
    Department of Urologic Surgery, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Ann N Y Acad Sci 1061:77-93. 2005
  5. ncbi Epididymis-specific promoter-driven gene targeting: a transcription factor which regulates epididymis-specific gene expression
    Kichiya Suzuki
    Department of Urologic Surgery, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Mol Cell Endocrinol 250:184-9. 2006
  6. pmc Protein and ligand adaptation in a retinoic acid binding protein
    R Pattanayek
    Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Protein Sci 8:2027-32. 1999
  7. ncbi Profiling and imaging proteins in the mouse epididymis by imaging mass spectrometry
    Pierre Chaurand
    Mass Spectrometry Research Center and Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN, USA
    Proteomics 3:2221-39. 2003
  8. ncbi Molecular evolution of epididymal lipocalin genes localized on mouse chromosome 2
    Kichiya Suzuki
    Department of Urologic Surgery, Vanderbilt University School of Medicine, Room A 1302 MCN, 1161 21st Avenue South, Nashville, TN 37232, USA
    Gene 339:49-59. 2004
  9. ncbi The role of forkhead box A2 to restrict androgen-regulated gene expression of lipocalin 5 in the mouse epididymis
    Xiuping Yu
    Department of Urologic Surgery, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Mol Endocrinol 20:2418-31. 2006
  10. ncbi Gene duplication gives rise to a new 17-kilodalton lipocalin that shows epididymal region-specific expression and testicular factor(s) regulation
    J J Lareyre
    Department of Obstetrics and Gynecology, Vanderbilt University, Nashville, Tennessee 37232, USA
    Endocrinology 142:1296-308. 2001

Research Grants

  1. VITAMIN A AND REPRODUCTION
    David Ong; Fiscal Year: 2004
  2. BINDING PROTEINS FOR COMPOUNDS WITH VITAMIN A ACTIVITY
    David Ong; Fiscal Year: 2005

Scientific Experts

  • Jean-Philippe Salier
  • J J Lareyre
  • David Ong
  • Kichiya Suzuki
  • Xiuping Yu
  • Marie Claire Orgebin-Crist
  • Robert J Matusik
  • Pierre Chaurand
  • Yoshihiko Araki
  • Richard M Caprioli
  • Yu Ru Zhang
  • Yongqing Wang
  • Aparna Gupta
  • Manickavasagam Sundaram
  • Jing Fei Huang
  • Yu Qi Zhao
  • H Li
  • R Pattanayek
  • Renjie Jin
  • Robert Matusik
  • Janni Mirosevich
  • Gabriel Gutierrez
  • Diego Sanchez
  • Sophie Fouchécourt
  • Beverly B DaGue
  • Baogang J Xu
  • Michelle L Reyzer
  • Daan M F van Aalten
  • John B C Findlay
  • Asipu Sivaprasadarao
  • T Arai
  • K Tago
  • H Iwahana
  • K Yanagisawa
  • K Kuroiwa
  • K Io
  • S Tominaga
  • M E Newcomer
  • T L Rankin
  • M C Orgebin-Crist
  • M K Holland
  • K J Tsuruta
  • M D Griswold
  • J T Vreeburg
  • G A Cornwall

Detail Information

Publications20

  1. pmc Retinoid-binding proteins: similar protein architectures bind similar ligands via completely different ways
    Yu Ru Zhang
    State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China
    PLoS ONE 7:e36772. 2012
    ..Plasma retinol-binding protein (RBP) and epididymal retinoic acid binding protein (ERABP) carry retinoids in bodily fluids, while cellular retinol-binding proteins (CRBPs) and ..
  2. ncbi Epididymis-specific lipocalin promoters
    Kichiya Suzuki
    Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    Asian J Androl 9:515-21. 2007
    ..These are differently regulated and regionalized in the epididymis. Lipocalin 5 (Lcn5 or mE-RABP) and Lipocalin 8 (Lcn8 or mEP17) are homologous genes belonging to the epididymis-specific lipocalin ..
  3. pmc The transfer of transthyretin and receptor-binding properties from the plasma retinol-binding protein to the epididymal retinoic acid-binding protein
    Manickavasagam Sundaram
    School of Biochemistry and Molecular Biology, University of Leeds, Leeds LS2 9JT, UK
    Biochem J 362:265-71. 2002
    ..retinol-binding protein (RBP) and its close structural homologue the epididymal retinoic acid-binding protein (ERABP)...
  4. ncbi Foxa1 and Foxa2 interact with the androgen receptor to regulate prostate and epididymal genes differentially
    Xiuping Yu
    Department of Urologic Surgery, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Ann N Y Acad Sci 1061:77-93. 2005
    ..Further, Foxa2 interacts with the AR to regulate the mouse epididymal retinoic acid binding protein (mE-RABP) gene, an epididymis-specific gene...
  5. ncbi Epididymis-specific promoter-driven gene targeting: a transcription factor which regulates epididymis-specific gene expression
    Kichiya Suzuki
    Department of Urologic Surgery, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Mol Cell Endocrinol 250:184-9. 2006
    ..Lipocalin 5 [Lcn5 or epididymal retinoic acid-binding protein (E-RABP)] is a member of this epididymis-specific lipocalin gene ..
  6. pmc Protein and ligand adaptation in a retinoic acid binding protein
    R Pattanayek
    Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Protein Sci 8:2027-32. 1999
    A retinoic acid binding protein isolated from the lumen of the rat epididymis (ERABP) is a member of the lipocalin superfamily...
  7. ncbi Profiling and imaging proteins in the mouse epididymis by imaging mass spectrometry
    Pierre Chaurand
    Mass Spectrometry Research Center and Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN, USA
    Proteomics 3:2221-39. 2003
    ..Furthermore, from the signal intensities observed in the different protein profiles organized in space, semiquantitative information for each protein was obtained...
  8. ncbi Molecular evolution of epididymal lipocalin genes localized on mouse chromosome 2
    Kichiya Suzuki
    Department of Urologic Surgery, Vanderbilt University School of Medicine, Room A 1302 MCN, 1161 21st Avenue South, Nashville, TN 37232, USA
    Gene 339:49-59. 2004
    We previously identified two murine secretory proteins, mE-RABP(Lcn5) and mEP17(Lcn8), belonging to the lipocalin family and specifically expressed in the epididymis. The genes are contiguous and localized on mouse chromosome 2...
  9. ncbi The role of forkhead box A2 to restrict androgen-regulated gene expression of lipocalin 5 in the mouse epididymis
    Xiuping Yu
    Department of Urologic Surgery, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Mol Endocrinol 20:2418-31. 2006
    Murine epididymal retinoic acid-binding protein [or lipocalin 5 (Lcn5)] is synthesized and secreted by the principal cells of the mouse middle/distal caput epididymidis...
  10. ncbi Gene duplication gives rise to a new 17-kilodalton lipocalin that shows epididymal region-specific expression and testicular factor(s) regulation
    J J Lareyre
    Department of Obstetrics and Gynecology, Vanderbilt University, Nashville, Tennessee 37232, USA
    Endocrinology 142:1296-308. 2001
    ..Together our results suggest that mE-RABP and mEP17 genes were generated by duplication and that evolution led to a different region-specific gene expression and regulation in the epididymis...
  11. ncbi Characterization of an androgen-specific response region within the 5' flanking region of the murine epididymal retinoic acid binding protein gene
    J J Lareyre
    Department of Obstetrics and Gynecology, Vanderbilt University, School of Medicine, Nashville, Tennessee 37232 2633, USA
    Biol Reprod 63:1881-92. 2000
    ..In conclusion, the mE-RABP ARR is a good model for the study of molecular mechanisms that lead to an androgen-specific responsiveness in vivo...
  12. ncbi Epididymal retinoic acid-binding protein
    D E Ong
    Department of Biochemistry, Vanderbilt University, School of Medicine, Nashville, TN 37232, USA
    Biochim Biophys Acta 1482:209-17. 2000
  13. ncbi Chromosomal location, exon/intron organization and evolution of lipocalin genes
    J P Salier
    INSERM Unit 519 and Institut Fédératif de Recherches Multidisciplinaires sur les Peptides, Faculte de Medecine Pharmacie, 22 Bvd Gambetta, 76183 Rouen Cedex, France
    Biochim Biophys Acta 1482:25-34. 2000
    ....
  14. ncbi The cloning and nucleotide sequence of human ST2L cDNA
    H Li
    Department of Biochemistry, Jichi Medical School, Tochigi, Japan
    Genomics 67:284-90. 2000
    ..We also established stable transfectants of a human glioblastoma cell line, T98G, that express human ST2L constitutively, and we confirmed cell-surface expression of human ST2L protein on the transfectants...
  15. ncbi A 5-kilobase pair promoter fragment of the murine epididymal retinoic acid-binding protein gene drives the tissue-specific, cell-specific, and androgen-regulated expression of a foreign gene in the epididymis of transgenic mice
    J J Lareyre
    Department of Obstetrics and Gynecology, Vanderbilt University, School of Medicine, Nashville, Tennessee 37232 2633, USA
    J Biol Chem 274:8282-90. 1999
    ..Altogether, our results demonstrate that the 5-kb promoter fragment of the mE-RABP gene contains all of the information required for the hormonal regulation and the spatial and temporal expression of the mE-RABP gene in the epididymis...
  16. ncbi Genomic organization and chromosomal localization of the murine epididymal retinoic acid-binding protein (mE-RABP) gene
    J J Lareyre
    Department of Obstetrics and Gynecology, Vanderbilt University, School of Medicine, Nashville, Tennessee 37232 2633, USA
    Mol Reprod Dev 50:387-95. 1998
    ..Our data, combined with that of others, suggest that the proximal segment of the mouse chromosome 2 may be a rich region for genes encoding lipocalins with a genomic organization highly related to the mE-RABP gene...
  17. ncbi Molecular cloning and hormonal regulation of a murine epididymal retinoic acid-binding protein messenger ribonucleic acid
    J J Lareyre
    Department of Obstetrics and Gynecology, Vanderbilt University, School of Medicine, Nashville, Tennessee 37232 2633, USA
    Endocrinology 139:2971-81. 1998
    ..secretory protein MEP 10 (mouse epididymal protein 10) was cloned and is now renamed murine epididymal retinoic acid binding protein (mE-RABP)...
  18. ncbi Secretion and transport of mouse epididymal proteins after injection of 35S-methionine
    J T Vreeburg
    Department of Endocrinology, Faculty of Medicine, Erasmus University, Rotterdam, The Netherlands
    Biol Reprod 43:113-20. 1990
    ..Five days after injection, the three proteins were found in Regions 4 and 5. However, the 25-kDa protein was present in reduced amount, whereas the 18- and 29-kDa proteins accumulated in caudal fluid.(ABSTRACT TRUNCATED AT 250 WORDS)..
  19. ncbi The 18-kDa mouse epididymal protein (MEP 10) binds retinoic acid
    T L Rankin
    Department of Cell Biology, Vanderbilt University, Nashville, Tennessee 37232
    Biol Reprod 46:767-71. 1992
    ..Similar ligand specificity has also been described for the rat proteins B and C by Ong and Chytil [Arch Biochem Biophys' 1988; 267:474-478].(ABSTRACT TRUNCATED AT 250 WORDS)..
  20. ncbi Isolation, immunolocalization, and sperm-association of three proteins of 18, 25, and 29 kilodaltons secreted by the mouse epididymis
    T L Rankin
    Department of Cell Biology, Vanderbilt University, Nashville, Tennessee 37232
    Biol Reprod 46:747-66. 1992
    ..The related rat protein migrated at approximately 20 kDa. Amino acid sequence analysis of MEP 10 revealed an 86% sequence similarity with rat proteins B and C.(ABSTRACT TRUNCATED AT 400 WORDS)..

Research Grants2

  1. VITAMIN A AND REPRODUCTION
    David Ong; Fiscal Year: 2004
    ..Regulation of retinoic acid production by estrogen has direct importance for understanding/treating conditions such as endometriosis, breast cancer, and cancers of the female reproductive system. ..
  2. BINDING PROTEINS FOR COMPOUNDS WITH VITAMIN A ACTIVITY
    David Ong; Fiscal Year: 2005
    ..These studies will increase our understanding of the essential role of retinoids in maintaining many epithelia, particularly epithelial prone to pathological conditions such as cancer. ..