Gene Symbol: Ephb3
Description: Eph receptor B3
Alias: AW456895, Cek10, Etk2, HEK2, MDK5, Sek4, Tyro6, ephrin type-B receptor 3, developmental kinase 5, mDK-5, tyrosine-protein kinase receptor SEK-4
Species: mouse
Products:     Ephb3

Top Publications

  1. Mendes S, Henkemeyer M, Liebl D. Multiple Eph receptors and B-class ephrins regulate midline crossing of corpus callosum fibers in the developing mouse forebrain. J Neurosci. 2006;26:882-92 pubmed
    ..Our results support a significant role for ephrins and Eph receptors in CC development and may provide insight to possible mechanisms involved in axon midline crossing and human disorder. ..
  2. Hsieh C, Nakamura P, Luk S, MIKO I, Henkemeyer M, Cramer K. Ephrin-B reverse signaling is required for formation of strictly contralateral auditory brainstem pathways. J Neurosci. 2010;30:9840-9 pubmed publisher
    ..We found that mice with null mutations in EphB2 and EphB3 had normal contralateral VCN-MNTB projections, yet these projections also had significant numbers of aberrant ..
  3. Howard M, Rodenas Ruano A, Henkemeyer M, Martin G, Lonsbury Martin B, Liebl D. Eph receptor deficiencies lead to altered cochlear function. Hear Res. 2003;178:118-30 pubmed
    ..In particular, EphB1 and EphB3 receptor knockout mice exhibited significantly diminished DPOAE levels as compared to wild-type littermates, ..
  4. Holmberg J, Genander M, Halford M, Annerén C, Sondell M, Chumley M, et al. EphB receptors coordinate migration and proliferation in the intestinal stem cell niche. Cell. 2006;125:1151-63 pubmed
    ..These data establish EphB receptors as key coordinators of migration and proliferation in the intestinal stem cell niche. ..
  5. Kayser M, McClelland A, Hughes E, Dalva M. Intracellular and trans-synaptic regulation of glutamatergic synaptogenesis by EphB receptors. J Neurosci. 2006;26:12152-64 pubmed
    ..Mice lacking EphB1-EphB3 have reduced numbers of synapses, and defects are rescued with postnatal reexpression of EphB2 in single neurons ..
  6. Chenaux G, Henkemeyer M. Forward signaling by EphB1/EphB2 interacting with ephrin-B ligands at the optic chiasm is required to form the ipsilateral projection. Eur J Neurosci. 2011;34:1620-33 pubmed publisher
  7. Egawa G, Osawa M, Uemura A, Miyachi Y, Nishikawa S. Transient expression of ephrin b2 in perinatal skin is required for maintenance of keratinocyte homeostasis. J Invest Dermatol. 2009;129:2386-95 pubmed publisher
  8. Williams S, Mann F, Erskine L, Sakurai T, Wei S, Rossi D, et al. Ephrin-B2 and EphB1 mediate retinal axon divergence at the optic chiasm. Neuron. 2003;39:919-35 pubmed
    ..EphB1 null mice exhibit a dramatically reduced ipsilateral projection, suggesting that this receptor contributes to the formation of the ipsilateral retinal projection, most likely through its repulsive interaction with ephrin-B2. ..
  9. Henkemeyer M, Itkis O, Ngo M, Hickmott P, Ethell I. Multiple EphB receptor tyrosine kinases shape dendritic spines in the hippocampus. J Cell Biol. 2003;163:1313-26 pubmed
    ..Analysis of EphB1, EphB2, and EphB3 double and triple mutant mice lacking these receptors in different combinations indicates that all three, although ..

More Information


  1. Xu N, Henkemeyer M. Ephrin-B3 reverse signaling through Grb4 and cytoskeletal regulators mediates axon pruning. Nat Neurosci. 2009;12:268-76 pubmed publisher
    ..Our results reveal a previously unknown pathway that controls axon pruning and elucidate the biochemical mechanism by which ephrin-B reverse signals regulate actin dynamics to bring about the retraction of growth cones. ..
  2. Hindges R, McLaughlin T, Genoud N, Henkemeyer M, O Leary D. EphB forward signaling controls directional branch extension and arborization required for dorsal-ventral retinotopic mapping. Neuron. 2002;35:475-87 pubmed
    ..Directed branch extension is disrupted in EphB2; EphB3-deficient mice resulting in lateral ectopic arbors...
  3. Genander M, Halford M, Xu N, Eriksson M, Yu Z, Qiu Z, et al. Dissociation of EphB2 signaling pathways mediating progenitor cell proliferation and tumor suppression. Cell. 2009;139:679-92 pubmed publisher
    ..The dissociation of EphB2 signaling pathways enables the selective inhibition of the mitogenic effect without affecting the tumor suppressor function and identifies a pharmacological strategy to suppress adenoma growth. ..
  4. Dravis C, Yokoyama N, Chumley M, Cowan C, Silvany R, Shay J, et al. Bidirectional signaling mediated by ephrin-B2 and EphB2 controls urorectal development. Dev Biol. 2004;271:272-90 pubmed
    ..for proper axon pathfinding in the developing nervous system, namely ephrin-B2 and the ephrin receptors EphB2 and EphB3, also play major roles in cell adhesion events that tubularize the urethra and partition the urinary and ..
  5. Kayser M, Nolt M, Dalva M. EphB receptors couple dendritic filopodia motility to synapse formation. Neuron. 2008;59:56-69 pubmed publisher
    ..Our findings provide a mechanistic link between dendritic filopodia motility and synapse differentiation. ..
  6. Theus M, Ricard J, Bethea J, Liebl D. EphB3 limits the expansion of neural progenitor cells in the subventricular zone by regulating p53 during homeostasis and following traumatic brain injury. Stem Cells. 2010;28:1231-42 pubmed publisher
    ..Here, we examined the role of ephrinB3-EphB3 signaling in mediating the SVZ response to traumatic brain injury (TBI)...
  7. Orioli D, Henkemeyer M, Lemke G, Klein R, Pawson T. Sek4 and Nuk receptors cooperate in guidance of commissural axons and in palate formation. EMBO J. 1996;15:6035-49 pubmed
    b>Sek4 and Nuk are members of the Eph-related family of receptor protein-tyrosine kinases. These receptors interact with a set of cell surface ligands that have recently been implicated in axon guidance and fasciculation...
  8. Risley M, Garrod D, Henkemeyer M, McLean W. EphB2 and EphB3 forward signalling are required for palate development. Mech Dev. 2009;126:230-9 pubmed publisher
    ..Previous work had shown that the loss of ephrinB1 protein alone or compound loss of EphB2 and EphB3 leads to cleft palate...
  9. Chen Z, Sun C, Reuhl K, Bergemann A, Henkemeyer M, Zhou R. Abnormal hippocampal axon bundling in EphB receptor mutant mice. J Neurosci. 2004;24:2366-74 pubmed
    ..In mice deficient in EphB2 and EphB3, many hippocampal axons remain in bundles...
  10. Luria V, Krawchuk D, Jessell T, Laufer E, Kania A. Specification of motor axon trajectory by ephrin-B:EphB signaling: symmetrical control of axonal patterning in the developing limb. Neuron. 2008;60:1039-53 pubmed publisher
    ..The involvement of ephrin:Eph signaling in guiding both sets of motor axons raises the possibility that other signaling systems function primarily to refine or modulate a core Eph signaling program. ..
  11. Compagni A, Logan M, Klein R, Adams R. Control of skeletal patterning by ephrinB1-EphB interactions. Dev Cell. 2003;5:217-30 pubmed
    ..connections were arranged asymmetrically and sternebrae were fused, defects that were phenocopied in EphB2/EphB3 receptor mutants...
  12. Grunwald I, Korte M, Wolfer D, Wilkinson G, Unsicker K, Lipp H, et al. Kinase-independent requirement of EphB2 receptors in hippocampal synaptic plasticity. Neuron. 2001;32:1027-40 pubmed
    ..Interestingly, targeted expression of a carboxy-terminally truncated form of EphB2 rescued the EphB2 null phenotype, indicating that EphB2 kinase signaling is not required for these EphB2-mediated functions. ..
  13. Birgbauer E, Cowan C, Sretavan D, Henkemeyer M. Kinase independent function of EphB receptors in retinal axon pathfinding to the optic disc from dorsal but not ventral retina. Development. 2000;127:1231-41 pubmed
    ..We show that mice lacking both EphB2 and EphB3 receptor tyrosine kinases, but not each alone, exhibit increased frequency of RGC axon guidance errors to the ..
  14. Li G, Ji X, Gao H, Zhao J, Xu J, Sun Z, et al. EphB3 suppresses non-small-cell lung cancer metastasis via a PP2A/RACK1/Akt signalling complex. Nat Commun. 2012;3:667 pubmed publisher
    ..Here we find that despite overexpression of EphB3 in human non-small-cell lung cancer, as reported previously, the expression of its cognate ligands, either ephrin-..
  15. Cowan C, Yokoyama N, Bianchi L, Henkemeyer M, Fritzsch B. EphB2 guides axons at the midline and is necessary for normal vestibular function. Neuron. 2000;26:417-30 pubmed
    ..This suggests EphB2 may regulate ionic homeostasis and endolymph fluid production through macromolecular associations with membrane channels that transport chloride, bicarbonate, and water. ..
  16. Iwasato T, Katoh H, Nishimaru H, Ishikawa Y, Inoue H, Saito Y, et al. Rac-GAP alpha-chimerin regulates motor-circuit formation as a key mediator of EphrinB3/EphA4 forward signaling. Cell. 2007;130:742-53 pubmed
    ..They also highlight the role of a Rho family GTPase-activating protein as a key mediator of ephrin/Eph signaling. ..
  17. Batlle E, Bacani J, Begthel H, Jonkheer S, Jonkeer S, Gregorieff A, et al. EphB receptor activity suppresses colorectal cancer progression. Nature. 2005;435:1126-30 pubmed
    ..Our data demonstrate that loss of EphB expression represents a critical step in colorectal cancer progression. ..
  18. Halford M, Armes J, Buchert M, Meskenaite V, Grail D, Hibbs M, et al. Ryk-deficient mice exhibit craniofacial defects associated with perturbed Eph receptor crosstalk. Nat Genet. 2000;25:414-8 pubmed
    ..components of cytokine/growth factor signalling systems such as Tgf-alpha/Egfr, Eph receptors B2 and B3 (Ephb2 and Ephb3, respectively), Tgf-beta2, Tgf-beta3 and activin-betaA (ref. 3) as regulators of secondary palate development...
  19. McLaughlin T, Lim Y, Santiago A, O Leary D. Multiple EphB receptors mediate dorsal-ventral retinotopic mapping via similar bi-functional responses to ephrin-B1. Mol Cell Neurosci. 2014;63:24-30 pubmed publisher
    ..However, the relative contributions of EphBs and ephrin-B1 are not well understood. We examined EphB1, EphB2, and EphB3 mutant mice and find that each has ectopic arborizations of retinal axon branches lateral to their appropriate ..
  20. Raft S, Andrade L, Shao D, Akiyama H, Henkemeyer M, Wu D. Ephrin-B2 governs morphogenesis of endolymphatic sac and duct epithelia in the mouse inner ear. Dev Biol. 2014;390:51-67 pubmed publisher
    ..We propose that developmental dysplasias described here are a gene dose-sensitive cause of the vestibular dysfunction observed in EphB-Efnb2 signaling-deficient mice. ..
  21. Barthet G, Dunys J, Shao Z, Xuan Z, Ren Y, Xu J, et al. Presenilin mediates neuroprotective functions of ephrinB and brain-derived neurotrophic factor and regulates ligand-induced internalization and metabolism of EphB2 and TrkB receptors. Neurobiol Aging. 2013;34:499-510 pubmed publisher
    ..Together, our observations indicate that PS1 promotes neuronal survival by regulating neuroprotective functions of ligand-receptor systems. ..
  22. van Eyll J, Passante L, Pierreux C, Lemaigre F, Vanderhaeghen P, Rousseau G. Eph receptors and their ephrin ligands are expressed in developing mouse pancreas. Gene Expr Patterns. 2006;6:353-9 pubmed
    ..We conclude that specific members of the Eph/ephrin family are expressed in embryonic pancreas according to a dynamic temporal and regional pattern. ..
  23. Hoogenraad C, Milstein A, Ethell I, Henkemeyer M, Sheng M. GRIP1 controls dendrite morphogenesis by regulating EphB receptor trafficking. Nat Neurosci. 2005;8:906-15 pubmed
    ..Neurons from EphB1-EphB2-EphB3 triple knockout mice showed abnormal dendrite morphogenesis...
  24. Liuzzo A, Gray L, Wallace M, Gabriele M. The effects of Eph-ephrin mutations on pre-pulse inhibition in mice. Physiol Behav. 2014;135:232-6 pubmed publisher
    ..Along with ongoing neuroanatomical studies, this allows careful quantification of how the auditory anatomical, physiological and now behavioral phenotype is affected by changes in Eph-ephrin expression and functionality. ..
  25. Plas D, Dhande O, Lopez J, Murali D, Thaller C, Henkemeyer M, et al. Bone morphogenetic proteins, eye patterning, and retinocollicular map formation in the mouse. J Neurosci. 2008;28:7057-67 pubmed publisher
  26. García Ceca J, Alfaro D, Montero Herradón S, Zapata A. Eph/ephrinB signalling is involved in the survival of thymic epithelial cells. Immunol Cell Biol. 2013;91:130-8 pubmed publisher
    ..in vivo and in vitro experimental approaches to define the role played by the tyrosine kinase receptors EphB2 and EphB3 and their ligands, ephrinsB, in the survival of embryonic and newborn (NB) TECs...
  27. Foster K, Gordon J, Cardenas K, Veiga Fernandes H, Makinen T, Grigorieva E, et al. EphB-ephrin-B2 interactions are required for thymus migration during organogenesis. Proc Natl Acad Sci U S A. 2010;107:13414-9 pubmed publisher
    ..This implies a NC-derived cell-specific role of EphB-ephrin-B2 interactions in the collective migration of the thymic rudiment during organogenesis. ..
  28. Nakamura P, Hsieh C, Cramer K. EphB signaling regulates target innervation in the developing and deafferented auditory brainstem. Dev Neurobiol. 2012;72:1243-55 pubmed publisher
    ..We found that EphB2 and EphB3 reverse signaling are critical for the normal development of the projection from VCN to MNTB, but that successful ..
  29. Quina L, Pak W, Lanier J, Banwait P, Gratwick K, Liu Y, et al. Brn3a-expressing retinal ganglion cells project specifically to thalamocortical and collicular visual pathways. J Neurosci. 2005;25:11595-604 pubmed
    ..Brn3a is coexpressed extensively with the closely related factor Brn3b in the embryonic retina, and the effects of the loss of Brn3a in retinal development are not severe, suggesting partial redundancy of function in this gene class. ..
  30. Williams T, Williams M, Kuick R, Misek D, McDonagh K, Hanash S, et al. Candidate downstream regulated genes of HOX group 13 transcription factors with and without monomeric DNA binding capability. Dev Biol. 2005;279:462-80 pubmed
    ..Our results suggest that HOX protein-protein interactions without direct HOX DNA-binding may play a larger role in HOX transcriptional regulation than generally assumed, and DNA-binding appears critical for repression. ..
  31. Saeger B, Suhm M, Neubüser A. Ephrin/ephrin receptor expression during early stages of mouse inner ear development. Dev Dyn. 2011;240:1578-85 pubmed publisher
    ..5 and E10, and report their detailed expression patterns. Our results reveal dynamic expression of several members of the ephrin/Eph family consistent with functions in otic placode development, invagination and neuroblast delamination. ..
  32. Davy A, Bush J, Soriano P. Inhibition of gap junction communication at ectopic Eph/ephrin boundaries underlies craniofrontonasal syndrome. PLoS Biol. 2006;4:e315 pubmed
    ..Our results uncover a novel role for Eph/ephrins in regulating GJC in vivo and suggest that the pleiotropic defects seen in CFNS patients are due to improper regulation of GJC in affected tissues. ..
  33. Dravis C, Wu T, Chumley M, Yokoyama N, Wei S, Wu D, et al. EphB2 and ephrin-B2 regulate the ionic homeostasis of vestibular endolymph. Hear Res. 2007;223:93-104 pubmed
  34. North H, Zhao X, Kolk S, Clifford M, Ziskind D, Donoghue M. Promotion of proliferation in the developing cerebral cortex by EphA4 forward signaling. Development. 2009;136:2467-76 pubmed publisher
    ..Furthermore, overexpression of ephrin B1 stimulated cell division of neighboring cells, supporting the hypothesis that ephrin B1-initiated forward signaling of EphA4 promotes cortical cell division. ..
  35. Kamitori K, Tanaka M, Okuno Hirasawa T, Kohsaka S. Receptor related to tyrosine kinase RYK regulates cell migration during cortical development. Biochem Biophys Res Commun. 2005;330:446-53 pubmed
    ..In this study, we demonstrated that RYK, EphB2, EphB3, ephrinB1, and ephrinB2 are expressed in embryonic brain...
  36. Fu C, Sretavan D. Involvement of EphB/Ephrin-B signaling in axonal survival in mouse experimental glaucoma. Invest Ophthalmol Vis Sci. 2012;53:76-84 pubmed publisher
    ..In a loss-of-function approach, mouse mutants lacking EphB2 (EphB2(-/-)) or EphB3 (EphB3(-/-)) protein, and mutants expressing EphB2 truncated in the C-terminus (EphB2(lacZ/lacZ)) were subjected ..
  37. Trokovic N, Trokovic R, Mai P, Partanen J. Fgfr1 regulates patterning of the pharyngeal region. Genes Dev. 2003;17:141-53 pubmed
    ..Our results indicate that Fgfr1 patterns the pharyngeal region to create a permissive environment for neural crest cell migration. ..
  38. Tsenkina Y, Ricard J, Runko E, Quiala Acosta M, Mier J, Liebl D. EphB3 receptors function as dependence receptors to mediate oligodendrocyte cell death following contusive spinal cord injury. Cell Death Dis. 2015;6:e1922 pubmed publisher
    We demonstrate that EphB3 receptors mediate oligodendrocyte (OL) cell death in the injured spinal cord through dependence receptor mechanism. OLs in the adult spinal cord express EphB3 as well as other members of the Eph receptor family...
  39. Mui S, Hindges R, O Leary D, Lemke G, Bertuzzi S. The homeodomain protein Vax2 patterns the dorsoventral and nasotemporal axes of the eye. Development. 2002;129:797-804 pubmed
    ..Vax2 mutants also exhibit flattened DV and NT gradients of the EphA5, EphB2, EphB3, ephrin-B1 and ephrin-B2 axon guidance cues...
  40. Becker N, Seitanidou T, Murphy P, Mattei M, Topilko P, Nieto M, et al. Several receptor tyrosine kinase genes of the Eph family are segmentally expressed in the developing hindbrain. Mech Dev. 1994;47:3-17 pubmed
    ..1992; Nieto et al., 1992), these data indicate that members of the Eph family of RTKs may co-operate in the segmental patterning of the hindbrain. ..
  41. Theus M, Ricard J, Glass S, Travieso L, Liebl D. EphrinB3 blocks EphB3 dependence receptor functions to prevent cell death following traumatic brain injury. Cell Death Dis. 2014;5:e1207 pubmed publisher
    ..Here, we examined whether EphB3 mediates cell death in the adult forebrain following traumatic brain injury and whether ephrinB3 infusion could ..
  42. Luxey M, Jungas T, Laussu J, Audouard C, Garces A, Davy A. Eph:ephrin-B1 forward signaling controls fasciculation of sensory and motor axons. Dev Biol. 2013;383:264-74 pubmed publisher
    ..Altogether, our results highlight the complex role of Eph:ephrin signaling in the development of the sensory-motor circuit innervating the limb. ..
  43. Batlle E, Henderson J, Beghtel H, van den Born M, Sancho E, Huls G, et al. Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB. Cell. 2002;111:251-63 pubmed
    ..We show here that beta-catenin and TCF inversely control the expression of the EphB2/EphB3 receptors and their ligand ephrin-B1 in colorectal cancer and along the crypt-villus axis...
  44. Wilkinson G, Schittny J, Reinhardt D, Klein R. Role for ephrinB2 in postnatal lung alveolar development and elastic matrix integrity. Dev Dyn. 2008;237:2220-34 pubmed publisher
    ..Postnatal day 1 mutant lungs show extracellular matrix alterations without differences in proportions of major distal cell populations. We conclude that lung alveolar formation relies on endothelial ephrinB2 function. ..
  45. Thakar S, Chenaux G, Henkemeyer M. Critical roles for EphB and ephrin-B bidirectional signalling in retinocollicular mapping. Nat Commun. 2011;2:431 pubmed publisher
    ..These data demonstrate that both forward and reverse signalling initiated by EphB:ephrin-B interactions have a major role in dorsoventral retinal ganglion cell axon termination along the mediolateral axis of the superior colliculus. ..
  46. Dennler S, Andre J, Alexaki I, Li A, Magnaldo T, Ten Dijke P, et al. Induction of sonic hedgehog mediators by transforming growth factor-beta: Smad3-dependent activation of Gli2 and Gli1 expression in vitro and in vivo. Cancer Res. 2007;67:6981-6 pubmed
    ..We thus identify TGF-beta as a potent transcriptional inducer of Gli transcription factors. Targeting the cooperation of Hh and TGF-beta signaling may provide new therapeutic opportunities for cancer treatment. ..
  47. Foo S, Turner C, Adams S, Compagni A, Aubyn D, Kogata N, et al. Ephrin-B2 controls cell motility and adhesion during blood-vessel-wall assembly. Cell. 2006;124:161-73 pubmed
    ..Our results indicate that the role of ephrin-B2 and EphB receptors in these processes involves Crk-p130(CAS) signaling and suggest that ephrin-B2 has some cell-cell-contact-independent functions. ..
  48. Intskirveli I, Metherate R, Cramer K. Null mutations in EphB receptors decrease sharpness of frequency tuning in primary auditory cortex. PLoS ONE. 2011;6:e26192 pubmed publisher
    ..We examined mice with null mutations in EphB2 and EphB3, as these mice show significant changes in auditory brainstem connectivity...
  49. Jevince A, Kadison S, Pittman A, Chien C, Kaprielian Z. Distribution of EphB receptors and ephrin-B1 in the developing vertebrate spinal cord. J Comp Neurol. 2006;497:734-50 pubmed
    ..generation and characterization of two new monoclonal antibodies, mAb EfB1-3, which recognizes EphB1, EphB2, and EphB3, and mAb efrnB1, which is specific for ephrin-B1...
  50. Alfaro D, Muñoz J, García Ceca J, Cejalvo T, Jiménez E, Zapata A. The Eph/ephrinB signal balance determines the pattern of T-cell maturation in the thymus. Immunol Cell Biol. 2011;89:844-52 pubmed publisher
    ..The obtained results demonstrate that EphB2 contributes more significantly than EphB3 in the control of CD4(-)CD8(-) (DN)-CD4(+)CD8(+) (DP) progression, and that reverse signals generated in SCID mice ..
  51. Ho S, Kovacevic N, Henkelman R, Boyd A, Pawson T, Henderson J. EphB2 and EphA4 receptors regulate formation of the principal inter-hemispheric tracts of the mammalian forebrain. Neuroscience. 2009;160:784-95 pubmed publisher
  52. Imondi R, Jevince A, Helms A, Johnson J, Kaprielian Z. Mis-expression of L1 on pre-crossing spinal commissural axons disrupts pathfinding at the ventral midline. Mol Cell Neurosci. 2007;36:462-71 pubmed
    ..These observations suggest that L1-mediated pathfinding decisions are normally delayed until axons have crossed the ventral midline (VM). ..
  53. Baumer S, Keller L, Holtmann A, Funke R, August B, Gamp A, et al. Vascular endothelial cell-specific phosphotyrosine phosphatase (VE-PTP) activity is required for blood vessel development. Blood. 2006;107:4754-62 pubmed
    ..No signs for enhanced endothelial apoptosis or proliferation were observed. Thus, the activity of VE-PTP is not required for the initial formation of blood vessels, yet it is essential for their maintenance and remodeling. ..
  54. Villar Cerviño V, Kappeler C, Nóbrega Pereira S, Henkemeyer M, Rago L, Nieto M, et al. Molecular mechanisms controlling the migration of striatal interneurons. J Neurosci. 2015;35:8718-29 pubmed publisher
    ..This study therefore reveals parallel mechanisms for the migration of MGE-derived interneurons to the striatum and the cerebral cortex. ..
  55. Bertuzzi S, Hindges R, Mui S, O Leary D, Lemke G. The homeodomain protein vax1 is required for axon guidance and major tract formation in the developing forebrain. Genes Dev. 1999;13:3092-105 pubmed
    ..Vax1 therefore regulates the guidance properties of a set of anterior midline cells that orchestrate axon trajectories in the developing mammalian forebrain. ..
  56. Frisen J, Barbacid M. Genetic analysis of the role of Eph receptors in the development of the mammalian nervous system. Cell Tissue Res. 1997;290:209-15 pubmed
    ..The recent generation of mutant mice lacking some of these receptors has made possible the dissection of the role that these molecules play in the development of the mammalian nervous system. ..
  57. Ciossek T, Lerch M, Ullrich A. Cloning, characterization, and differential expression of MDK2 and MDK5, two novel receptor tyrosine kinases of the eck/eph family. Oncogene. 1995;11:2085-95 pubmed
    ..homologous to the mouse kinase Myk-1 and the human kinase Htk, whereas MDK5 represents the mouse homologue of human Hek2. Northern blot analyses of adult mouse tissues revealed a 4.7 kb transcript of MDK2 and a 4...
  58. Perez E, Cepero M, Perez S, Coyle J, Sick T, Liebl D. EphB3 signaling propagates synaptic dysfunction in the traumatic injured brain. Neurobiol Dis. 2016;94:73-84 pubmed publisher
    ..We show that the receptor tyrosine kinase EphB3 participates in CCI injury-induced synaptic damage, where EphB3(-/-) mice show preserved long-term potentiation ..
  59. Wallace M, Harris J, Brubaker D, Klotz C, Gabriele M. Graded and discontinuous EphA-ephrinB expression patterns in the developing auditory brainstem. Hear Res. 2016;335:64-75 pubmed publisher
    ..Described tonotopic gradients and seemingly complementary modular/extramodular patterns suggest Eph-ephrin guidance in establishing juxtaposed continuous and discrete neural maps in the developing IC prior to experience. ..
  60. García Ceca J, Jiménez E, Alfaro D, Cejalvo T, Chumley M, Henkemeyer M, et al. On the role of Eph signalling in thymus histogenesis; EphB2/B3 and the organizing of the thymic epithelial network. Int J Dev Biol. 2009;53:971-82 pubmed publisher
    In the current study, we extend our own previous results on the thymocyte phenotype of EphB2 and/or EphB3 deficient mice by analyzing the phenotype and the histological organization of their thymic epithelial stroma...
  61. Liu X, Hawkes E, Ishimaru T, Tran T, Sretavan D. EphB3: an endogenous mediator of adult axonal plasticity and regrowth after CNS injury. J Neurosci. 2006;26:3087-101 pubmed
    ..Recruited macrophages specifically upregulated mRNA encoding the guidance molecule EphB3 and expressed EphB proteins capable of binding Ephrin B molecules in vivo and in vitro...
  62. Furuyama T, Kitayama K, Shimoda Y, Ogawa M, Sone K, Yoshida Araki K, et al. Abnormal angiogenesis in Foxo1 (Fkhr)-deficient mice. J Biol Chem. 2004;279:34741-9 pubmed
    ..These results suggest that Foxo1 is essential to the ability of endothelial cells to respond properly to a high dose of VEGF, thereby playing a critical role in normal vascular development. ..
  63. Birgbauer E, Oster S, Severin C, Sretavan D. Retinal axon growth cones respond to EphB extracellular domains as inhibitory axon guidance cues. Development. 2001;128:3041-8 pubmed
    ..In conclusion, development of neuronal connectivity may involve the combined activity of Eph proteins serving as guidance receptors and as axon guidance cues. ..
  64. Imondi R, Wideman C, Kaprielian Z. Complementary expression of transmembrane ephrins and their receptors in the mouse spinal cord: a possible role in constraining the orientation of longitudinally projecting axons. Development. 2000;127:1397-410 pubmed
    ..Taken together, these data support a possible role for repulsive B-class Eph receptor/ligand interactions in constraining the orientation of longitudinal axon projections at the ventral midline. ..
  65. Srivastava N, Robichaux M, Chenaux G, Henkemeyer M, Cowan C. EphB2 receptor forward signaling controls cortical growth cone collapse via Nck and Pak. Mol Cell Neurosci. 2013;52:106-16 pubmed publisher
  66. Villasenor A, Chong D, Henkemeyer M, Cleaver O. Epithelial dynamics of pancreatic branching morphogenesis. Development. 2010;137:4295-305 pubmed publisher
    ..Overall, these results illustrate distinct, step-wise cellular mechanisms by which pancreatic epithelium shapes itself to create a functional branching organ. ..
  67. Bush J, Soriano P. Ephrin-B1 forward signaling regulates craniofacial morphogenesis by controlling cell proliferation across Eph-ephrin boundaries. Genes Dev. 2010;24:2068-80 pubmed publisher
  68. Islam S, Loizides A, Fialkovich J, Grand R, Montgomery R. Developmental expression of Eph and ephrin family genes in mammalian small intestine. Dig Dis Sci. 2010;55:2478-88 pubmed publisher
    Eph receptor tyrosine kinases EphB2 and EphB3, and ephrin-B1 ligand play a critical role in regulating small intestinal epithelial cell migration...
  69. Noh H, Lee H, Park E, Park S. Proper closure of the optic fissure requires ephrin A5-EphB2-JNK signaling. Development. 2016;143:461-72 pubmed publisher
  70. Dominguez Brauer C, Hao Z, Elia A, Fortin J, Nechanitzky R, Brauer P, et al. Mule Regulates the Intestinal Stem Cell Niche via the Wnt Pathway and Targets EphB3 for Proteasomal and Lysosomal Degradation. Cell Stem Cell. 2016;19:205-216 pubmed publisher
    ..Mule also regulates protein levels of the receptor tyrosine kinase EphB3 by targeting it for proteasomal and lysosomal degradation...
  71. Ruiz J, Conlon F, Robertson E. Identification of novel protein kinases expressed in the myocardium of the developing mouse heart. Mech Dev. 1994;48:153-64 pubmed
    ..report, we describe the characterization of two of the genes corresponding to the novel PCR products (designated Hek2 and msk)...
  72. Funato N, Nakamura M, Richardson J, Srivastava D, Yanagisawa H. Tbx1 regulates oral epithelial adhesion and palatal development. Hum Mol Genet. 2012;21:2524-37 pubmed publisher
    ..Our present study reveals new pathogenesis of incomplete and submucous cleft palate during mammalian palatogenesis. ..