Epha2

Summary

Gene Symbol: Epha2
Description: Eph receptor A2
Alias: AW545284, Eck, Myk2, Sek-2, Sek2, ephrin type-A receptor 2, epithelial cell kinase, tyrosine-protein kinase receptor ECK, tyrosine-protein kinase receptor MPK-5, tyrosine-protein kinase receptor SEK-2
Species: mouse
Products:     Epha2

Top Publications

  1. Sirbu I, Gresh L, Barra J, Duester G. Shifting boundaries of retinoic acid activity control hindbrain segmental gene expression. Development. 2005;132:2611-22 pubmed
    ..These two pulses of RA activity function to establish expression of Hoxb1 and vHnf1 on opposite sides of the r4/r5 boundary. ..
  2. Khounlotham M, Subbian S, Smith R, Cirillo S, Cirillo J. Mycobacterium tuberculosis interferes with the response to infection by inducing the host EphA2 receptor. J Infect Dis. 2009;199:1797-806 pubmed publisher
    ..Mice infected with M. tuberculosis displayed higher expression of ephA1 and ephA2 as well as ephrinA1, which encodes the ligand for EphA1 and EphA2...
  3. Naruse Nakajima C, Asano M, Iwakura Y. Involvement of EphA2 in the formation of the tail notochord via interaction with ephrinA1. Mech Dev. 2001;102:95-105 pubmed
    Eph receptors have been implicated in cell-to-cell interaction during embryogenesis. We generated EphA2 mutant mice using a gene trap method. Homozygous mutant mice developed short and kinky tails...
  4. Guo H, Miao H, Gerber L, Singh J, Denning M, Gilliam A, et al. Disruption of EphA2 receptor tyrosine kinase leads to increased susceptibility to carcinogenesis in mouse skin. Cancer Res. 2006;66:7050-8 pubmed
    b>EphA2 receptor tyrosine kinase is frequently overexpressed in different human cancers, suggesting that it may promote tumor development and progression...
  5. Okazaki T, Ni A, Baluk P, Ayeni O, Kearley J, Coyle A, et al. Capillary defects and exaggerated inflammatory response in the airways of EphA2-deficient mice. Am J Pathol. 2009;174:2388-99 pubmed publisher
    ..Recent studies suggested that EphA2 inhibition reduces tumor angiogenesis, but its role in blood vessel development and inflammation is unclear...
  6. Carpenter T, Schroeder W, Stenmark K, Schmidt E. Eph-A2 promotes permeability and inflammatory responses to bleomycin-induced lung injury. Am J Respir Cell Mol Biol. 2012;46:40-7 pubmed publisher
    Stimulation by the ephrin-A1 ligand of the EphA2 receptor increases endothelial permeability. Lung injury increases the expression of EphA2, but the role of EphA2 in such injury is not well understood...
  7. Shi Y, De Maria A, BENNETT T, Shiels A, Bassnett S. A role for epha2 in cell migration and refractive organization of the ocular lens. Invest Ophthalmol Vis Sci. 2012;53:551-9 pubmed publisher
    The Epha2 receptor is a surprisingly abundant component of the membrane proteome of vertebrate lenses...
  8. Cheng C, Gong X. Diverse roles of Eph/ephrin signaling in the mouse lens. PLoS ONE. 2011;6:e28147 pubmed publisher
    ..We have investigated the molecular mechanisms of cataractogenesis and the roles of ephrin-A5 and EphA2 in the lens...
  9. Cooper M, Son A, Komlos D, Sun Y, Kleiman N, Zhou R. Loss of ephrin-A5 function disrupts lens fiber cell packing and leads to cataract. Proc Natl Acad Sci U S A. 2008;105:16620-5 pubmed publisher
    ..We further demonstrate that ephrin-A5 interacts with the EphA2 receptor to regulate the adherens junction complex by enhancing recruitment of beta-catenin to N-cadherin...

More Information

Publications84

  1. Jun G, Guo H, Klein B, Klein R, Wang J, Mitchell P, et al. EPHA2 is associated with age-related cortical cataract in mice and humans. PLoS Genet. 2009;5:e1000584 pubmed publisher
    ..We report that homozygous deletion of Epha2 in two independent strains of mice developed progressive cortical cataract...
  2. Gale N, Holland S, Valenzuela D, Flenniken A, Pan L, Ryan T, et al. Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis. Neuron. 1996;17:9-19 pubmed
    ..This reciprocal compartmentalization implicates the Eph family in the formation of spatial boundaries that may help to organize the developing body plan. ..
  3. Yun M, Johnson R, Antic A, Donoghue M. EphA family gene expression in the developing mouse neocortex: regional patterns reveal intrinsic programs and extrinsic influence. J Comp Neurol. 2003;456:203-16 pubmed
  4. Shaut C, Saneyoshi C, Morgan E, Knosp W, Sexton D, Stadler H. HOXA13 directly regulates EphA6 and EphA7 expression in the genital tubercle vascular endothelia. Dev Dyn. 2007;236:951-60 pubmed
    ..Together these findings indicate that HOXA13 directly regulates EphA6 and EphA7 in the developing GT and identifies the GT vascular endothelia as a novel site for HOXA13-dependent expression of EphA6 and EphA7. ..
  5. Bogan C, Chen J, O Sullivan M, Cormier R. Loss of EphA2 receptor tyrosine kinase reduces ApcMin/+ tumorigenesis. Int J Cancer. 2009;124:1366-71 pubmed publisher
    The Eph receptor A2 (EphA2) is overexpressed in a range of human epithelial cancers, a phenotype that is associated with cancer cell proliferation, progression and angiogenesis...
  6. Mark M, Scadden D, Wang Z, Gu Q, Goddard A, Godowski P. rse, a novel receptor-type tyrosine kinase with homology to Axl/Ufo, is expressed at high levels in the brain. J Biol Chem. 1994;269:10720-8 pubmed
    ..The gene for rse was localized to human chromosome 15. ..
  7. Du X, Baldwin C, Hooker E, Glorion P, Lemay S. Basal and Src kinase-mediated activation of the EphA2 promoter requires a cAMP-responsive element but is CREB-independent. J Cell Biochem. 2011;112:1268-76 pubmed publisher
    We have previously identified the EphA2 receptor tyrosine kinase as a potentially important injury-responsive gene and a transcriptional target of Src kinase activity in renal ischemia-reperfusion injury (IRI)...
  8. Pandey A, Lazar D, Saltiel A, Dixit V. Activation of the Eck receptor protein tyrosine kinase stimulates phosphatidylinositol 3-kinase activity. J Biol Chem. 1994;269:30154-7 pubmed
    The Eph/Eck subfamily of receptor protein tyrosine kinases is currently the largest subfamily of receptor protein tyrosine kinases with a dozen members (Van der Geer, P., Hunter, T., and Lindberg, R. A. (1994) Annu. Rev. Cell Biol...
  9. Ruiz J, Robertson E. The expression of the receptor-protein tyrosine kinase gene, eck, is highly restricted during early mouse development. Mech Dev. 1994;46:87-100 pubmed
    ..Here, we analyze the expression of eck, a member of the eph family of R-PTKs, during gastrulation and early organogenesis by in situ hybridization...
  10. Gale N, Yancopoulos G. Growth factors acting via endothelial cell-specific receptor tyrosine kinases: VEGFs, angiopoietins, and ephrins in vascular development. Genes Dev. 1999;13:1055-66 pubmed
  11. DuSablon A, Kent S, Coburn A, Virag J. EphA2-receptor deficiency exacerbates myocardial infarction and reduces survival in hyperglycemic mice. Cardiovasc Diabetol. 2014;13:114 pubmed publisher
    ..exogenous EphrinA1-Fc administration following MI positively influences wound healing, and that deletion of the EphA2 Receptor (EphA2-R) exacerbates injury and remodeling...
  12. Goodwin R, Din W, Davis Smith T, Anderson D, Gimpel S, Sato T, et al. Molecular cloning of a ligand for the inducible T cell gene 4-1BB: a member of an emerging family of cytokines with homology to tumor necrosis factor. Eur J Immunol. 1993;23:2631-41 pubmed
    ..Interaction of 4-1BB with its ligand induces the proliferation of activated thymocytes and splenic T cells, a response which is mimicked on similar cell populations stimulated with an antibody to 4-1BB. ..
  13. Mutoji K, Singh A, Nguyen T, Gildersleeve H, Kaucher A, Oatley M, et al. TSPAN8 Expression Distinguishes Spermatogonial Stem Cells in the Prepubertal Mouse Testis. Biol Reprod. 2016;95:117 pubmed
    ..at the single-cell level among undifferentiated spermatogonia from Postnatal Day 6 mouse testes, including Tspan8, Epha2, and Pvr, each of which encode cell surface proteins useful for cell selection...
  14. Cai W, Ebrahimnejad A, Chen K, Cao Q, Li Z, Tice D, et al. Quantitative radioimmunoPET imaging of EphA2 in tumor-bearing mice. Eur J Nucl Med Mol Imaging. 2007;34:2024-36 pubmed
    b>EphA2 receptor tyrosine kinase is significantly overexpressed in a wide variety of cancer types. High EphA2 expression has been correlated with increased metastatic potential and poor patient survival...
  15. Vaught D, Chen J, Brantley Sieders D. Regulation of mammary gland branching morphogenesis by EphA2 receptor tyrosine kinase. Mol Biol Cell. 2009;20:2572-81 pubmed publisher
    Eph receptor tyrosine kinases, including EphA2, are expressed in the mammary gland. However, their role in mammary gland development remains poorly understood...
  16. Tanaka M, Ohashi R, Nakamura R, Shinmura K, Kamo T, Sakai R, et al. Tiam1 mediates neurite outgrowth induced by ephrin-B1 and EphA2. EMBO J. 2004;23:1075-88 pubmed
    ..here that the interaction of a Rac1-specific guanine nucleotide-exchanging factor, Tiam1, with ephrin-B1 and EphA2 mediates neurite outgrowth...
  17. Brantley Sieders D, Fang W, Hicks D, Zhuang G, Shyr Y, Chen J. Impaired tumor microenvironment in EphA2-deficient mice inhibits tumor angiogenesis and metastatic progression. FASEB J. 2005;19:1884-6 pubmed
    b>EphA2 belongs to a unique family of receptor tyrosine kinases that play critical roles in development and disease...
  18. Youngblood V, Wang S, Song W, Walter D, Hwang Y, Chen J, et al. Elevated Slit2 Activity Impairs VEGF-Induced Angiogenesis and Tumor Neovascularization in EphA2-Deficient Endothelium. Mol Cancer Res. 2015;13:524-37 pubmed publisher
    ..While EphA2, a receptor tyrosine kinase (RTK), is required for VEGF-induced angiogenesis, the mechanism through which these ..
  19. Logan C, Rajakaruna S, Bowen C, Radice G, Robinson M, Menko A. N-cadherin regulates signaling mechanisms required for lens fiber cell elongation and lens morphogenesis. Dev Biol. 2017;428:118-134 pubmed publisher
    ..contacts between fiber cells during development, and the maintenance of Aquaporin-0 and increased expression of EphA2 at cell-cell interfaces suggests that these molecules may function in this role...
  20. Studer M, Lumsden A, Ariza McNaughton L, Bradley A, Krumlauf R. Altered segmental identity and abnormal migration of motor neurons in mice lacking Hoxb-1. Nature. 1996;384:630-4 pubmed
    ..These results demonstrate that, as a part of its role in maintaining rhombomere identity, Hoxb-1 is involved in controlling migratory properties of motor neurons in the hindbrain. ..
  21. Ganju P, Shigemoto K, Brennan J, Entwistle A, Reith A. The Eck receptor tyrosine kinase is implicated in pattern formation during gastrulation, hindbrain segmentation and limb development. Oncogene. 1994;9:1613-24 pubmed
    ..for additional receptor tyrosine kinases expressed during mouse embryogenesis we cloned the murine homolog of Eck, a member of the Eph subfamily, that maps to the distal region of mouse chromosome 4...
  22. Dunaway C, Hwang Y, Lindsley C, Cook R, Wu J, Boothby M, et al. Cooperative signaling between Slit2 and Ephrin-A1 regulates a balance between angiogenesis and angiostasis. Mol Cell Biol. 2011;31:404-16 pubmed publisher
    ..Our results suggest that the complex roles of Slit-Robo signaling in angiogenesis involve context-dependent mechanisms. ..
  23. Thundyil J, Manzanero S, Pavlovski D, Cully T, Lok K, Widiapradja A, et al. Evidence that the EphA2 receptor exacerbates ischemic brain injury. PLoS ONE. 2013;8:e53528 pubmed publisher
    ..We investigated the potential involvement of EphA2 receptors in ischemic stroke-induced brain inflammation in a mouse model of focal stroke...
  24. Fujii H, Tatsumi K, Kosaka K, Yoshioka S, Fujiwara H, Fujii S. Eph-ephrin A system regulates murine blastocyst attachment and spreading. Dev Dyn. 2006;235:3250-8 pubmed
    ..These findings suggest an important role of the Eph-ephrin A system in regulating the initial embryo-maternal contact during the cross-talk period that precedes embryo implantation. ..
  25. Yeddula N, Xia Y, Ke E, Beumer J, Verma I. Screening for tumor suppressors: Loss of ephrin receptor A2 cooperates with oncogenic KRas in promoting lung adenocarcinoma. Proc Natl Acad Sci U S A. 2015;112:E6476-85 pubmed publisher
    ..Ephrin receptorA2 (EphA2) is among the top candidate genes and was reconfirmed by two distinct shRNAs...
  26. Niederreither K, Vermot J, Schuhbaur B, Chambon P, Dolle P. Retinoic acid synthesis and hindbrain patterning in the mouse embryo. Development. 2000;127:75-85 pubmed
    ..We conclude that RA produced by the embryo is required to generate posterior cell fates in the developing mouse hindbrain, its absence leading to an abnormal r3 (and, to a lesser extent, r4) identity of the caudal hindbrain cells. ..
  27. Gundry C, Marco S, Rainero E, Miller B, Dornier E, Mitchell L, et al. Phosphorylation of Rab-coupling protein by LMTK3 controls Rab14-dependent EphA2 trafficking to promote cell:cell repulsion. Nat Commun. 2017;8:14646 pubmed publisher
    ..Here we identify an RTK of the Eph family, EphA2, to be a cargo of an RCP-regulated endocytic pathway which controls cell:cell repulsion and metastasis in vivo...
  28. Abdul Latif M, Salazar J, Marshak S, Dinh M, Cramer K. Ephrin-A2 and ephrin-A5 guide contralateral targeting but not topographic mapping of ventral cochlear nucleus axons. Neural Dev. 2015;10:27 pubmed publisher
    ..These classes may rely in part on common signaling pathways. ..
  29. Andres A, Reid H, Zurcher G, Blaschke R, Albrecht D, Ziemiecki A. Expression of two novel eph-related receptor protein tyrosine kinases in mammary gland development and carcinogenesis. Oncogene. 1994;9:1461-7 pubmed
    ..a novel member expressed predominantly in lung, heart and mammary gland and myk-2, a close relative of the human eck gene...
  30. Shao H, Pandey A, O Shea K, Seldin M, Dixit V. Characterization of B61, the ligand for the Eck receptor protein-tyrosine kinase. J Biol Chem. 1995;270:5636-41 pubmed
    ..Biol. 10, 5830-5838). It was recently discovered that soluble recombinant B61 could serve as a ligand for the Eck receptor protein-tyrosine kinase, a member of the Eph/Eck subfamily of receptor protein-tyrosine kinases (Bartley, ..
  31. Birkeland M, Copeland N, Gilbert D, Jenkins N, Barclay A. Gene structure and chromosomal localization of the mouse homologue of rat OX40 protein. Eur J Immunol. 1995;25:926-30 pubmed
  32. Ingham N, Steel K, Drescher U. On the role of ephrinA2 in auditory function. Hear Res. 2017;350:11-16 pubmed publisher
  33. Cheng C, Ansari M, Cooper J, Gong X. EphA2 and Src regulate equatorial cell morphogenesis during lens development. Development. 2013;140:4237-45 pubmed publisher
    ..In Epha2(-/-) mouse lenses, equatorial epithelial cells fail to form precisely aligned meridional rows; moreover, the lens ..
  34. Lindberg R, Hunter T. cDNA cloning and characterization of eck, an epithelial cell receptor protein-tyrosine kinase in the eph/elk family of protein kinases. Mol Cell Biol. 1990;10:6316-24 pubmed
    ..Immunohistochemical analysis of several rat organs also showed staining in epithelial cells. These observations prompted us to name this protein kinase eck, for epithelial cell kinase.
  35. Kim J, Lee H, Kim Y, Yoo S, Park E, Park S. The SAM domains of Anks family proteins are critically involved in modulating the degradation of EphA receptors. Mol Cell Biol. 2010;30:1582-92 pubmed publisher
    ..More importantly, the overexpression of wild-type Odin protected EphA8 and EphA2 from undergoing degradation following ligand stimulation and promoted EphA-mediated inhibition of cell migration...
  36. Lyckman A, Jhaveri S, Feldheim D, Vanderhaeghen P, Flanagan J, Sur M. Enhanced plasticity of retinothalamic projections in an ephrin-A2/A5 double mutant. J Neurosci. 2001;21:7684-90 pubmed
    ..The present findings thus show that the targeting of retinothalamic projections can be surgically manipulated in the mouse and that such plasticity can be controlled by proteins known to regulate topographic mapping. ..
  37. Scherer C, Chen J, Nachabeh A, Hopkins N, Ruley H. Transcriptional specificity of the pluripotent embryonic stem cell. Cell Growth Differ. 1996;7:1393-401 pubmed
    ..the germline, and expression of the beta geo fusion genes was analyzed in vivo, including inserts disrupting the Eck and REX-1 genes...
  38. Baldwin C, Chen Z, Bedirian A, Yokota N, Nasr S, Rabb H, et al. Upregulation of EphA2 during in vivo and in vitro renal ischemia-reperfusion injury: role of Src kinases. Am J Physiol Renal Physiol. 2006;291:F960-71 pubmed
    ..We found that one receptor in particular, EphA2, was strongly upregulated in the kidney following IRI...
  39. van Eyll J, Passante L, Pierreux C, Lemaigre F, Vanderhaeghen P, Rousseau G. Eph receptors and their ephrin ligands are expressed in developing mouse pancreas. Gene Expr Patterns. 2006;6:353-9 pubmed
    ..We conclude that specific members of the Eph/ephrin family are expressed in embryonic pancreas according to a dynamic temporal and regional pattern. ..
  40. Kaushansky A, Douglass A, Arang N, Vigdorovich V, Dambrauskas N, Kain H, et al. Malaria parasites target the hepatocyte receptor EphA2 for successful host infection. Science. 2015;350:1089-92 pubmed publisher
    ..We found that the hepatocyte EphA2 receptor was critical for establishing a permissive intracellular replication compartment, the parasitophorous ..
  41. Abu Abed S, Dolle P, Metzger D, Beckett B, Chambon P, Petkovich M. The retinoic acid-metabolizing enzyme, CYP26A1, is essential for normal hindbrain patterning, vertebral identity, and development of posterior structures. Genes Dev. 2001;15:226-40 pubmed
  42. Bovenkamp D, Greer P. Degenerate PCR-based cloning method for Eph receptors and analysis of their expression in the developing murine central nervous system and vasculature. DNA Cell Biol. 2001;20:203-13 pubmed
    ..cDNAs were also used to generate RNA in situ hybridization probes to examine the expression patterns of murine EphA2, A3, A4, A7, B1, B2, and B4 in 9.5-dpc mouse embryos...
  43. Son A, Cooper M, Sheleg M, Sun Y, Kleiman N, Zhou R. Further analysis of the lens of ephrin-A5-/- mice: development of postnatal defects. Mol Vis. 2013;19:254-66 pubmed
    ..Ephrin-A5 and the Eph receptor EphA2 are expressed during early ocular development and continue to be expressed into postnatal stages...
  44. Stark D, Coffey N, Pancoast H, Arnold L, Walker J, Vallée J, et al. Ephrin-A3 promotes and maintains slow muscle fiber identity during postnatal development and reinnervation. J Cell Biol. 2015;211:1077-91 pubmed publisher
    ..We therefore conclude that Eph/ephrin interactions guide the fiber type specificity of neuromuscular interactions during development and adult life. ..
  45. Günschmann C, Stachelscheid H, Akyuz M, Schmitz A, Missero C, Bruning J, et al. Insulin/IGF-1 controls epidermal morphogenesis via regulation of FoxO-mediated p63 inhibition. Dev Cell. 2013;26:176-87 pubmed publisher
    ..Collectively, the present study reveals a critical role for IIS-dependent control of p63 activity in coordination of ACD and stratification during epithelial morphogenesis. ..
  46. Amato K, Wang S, Hastings A, Youngblood V, Santapuram P, Chen H, et al. Genetic and pharmacologic inhibition of EPHA2 promotes apoptosis in NSCLC. J Clin Invest. 2014;124:2037-49 pubmed publisher
    Genome-wide analyses determined previously that the receptor tyrosine kinase (RTK) EPHA2 is commonly overexpressed in non-small cell lung cancers (NSCLCs)...
  47. Brantley Sieders D, Zhuang G, Hicks D, Fang W, Hwang Y, Cates J, et al. The receptor tyrosine kinase EphA2 promotes mammary adenocarcinoma tumorigenesis and metastatic progression in mice by amplifying ErbB2 signaling. J Clin Invest. 2008;118:64-78 pubmed
    Overexpression of the receptor tyrosine kinase EPH receptor A2 (EphA2) is commonly observed in aggressive breast cancer and correlates with a poor prognosis...
  48. De Bellard M, Ching W, Gossler A, Bronner Fraser M. Disruption of segmental neural crest migration and ephrin expression in delta-1 null mice. Dev Biol. 2002;249:121-30 pubmed
    ..Interestingly, absence of Delta-1 leads to diminution of both neurons and glia in peripheral ganglia, suggesting a general depletion of the ganglion precursor pool in mutant mice. ..
  49. Lickliter J, Smith F, Olsson J, Mackwell K, Boyd A. Embryonic stem cells express multiple Eph-subfamily receptor tyrosine kinases. Proc Natl Acad Sci U S A. 1996;93:145-50 pubmed
    ..Of these, eight were almost identical to one of four previously identified molecules (Sek, Nuk, Eck, and Mek4)...
  50. Chen J, Nachabah A, Scherer C, Ganju P, Reith A, Bronson R, et al. Germ-line inactivation of the murine Eck receptor tyrosine kinase by gene trap retroviral insertion. Oncogene. 1996;12:979-88 pubmed
    The present study characterized a mutation in the Eck receptor tyrosine kinase gene induced by the U3betageo gene trap retrovirus...
  51. Moore Scott B, Opoka R, Lin S, Kordich J, Wells J. Identification of molecular markers that are expressed in discrete anterior-posterior domains of the endoderm from the gastrula stage to mid-gestation. Dev Dyn. 2007;236:1997-2003 pubmed
    ..Two genes, Klf5 and Epha2 are expressed in posterior endoderm associated with the primitive streak...
  52. Michael S, Brennan J, Robertson E. Efficient gene-specific expression of cre recombinase in the mouse embryo by targeted insertion of a novel IRES-Cre cassette into endogenous loci. Mech Dev. 1999;85:35-47 pubmed
    ..We successfully demonstrate this approach by generating a Cre expressing allele of the EphA2 gene, an Eph receptor protein tyrosine kinase expressed early in development...
  53. Irie N, Takada Y, Watanabe Y, Matsuzaki Y, Naruse C, Asano M, et al. Bidirectional signaling through ephrinA2-EphA2 enhances osteoclastogenesis and suppresses osteoblastogenesis. J Biol Chem. 2009;284:14637-44 pubmed publisher
    ..Here we show that bidirectional ephrinA2-EphA2 signaling regulates bone remodeling at the initiation phase...
  54. Abdul Aziz N, Turmaine M, Greene N, Copp A. EphrinA-EphA receptor interactions in mouse spinal neurulation: implications for neural fold fusion. Int J Dev Biol. 2009;53:559-68 pubmed publisher
    ..Most ephrinAs and EphA receptors were found to be expressed in multiple tissues in the caudal region, whereas EphA2 receptor was expressed specifically at the apices of the neural folds just prior to onset of neural tube fusion...
  55. Fang W, Brantley Sieders D, Hwang Y, Ham A, Chen J. Identification and functional analysis of phosphorylated tyrosine residues within EphA2 receptor tyrosine kinase. J Biol Chem. 2008;283:16017-26 pubmed publisher
    b>EphA2 is a member of the Eph family of receptor tyrosine kinases. EphA2 mediates cell-cell communication and plays critical roles in a number of physiological and pathologic responses...
  56. Amato K, Wang S, Tan L, Hastings A, Song W, Lovly C, et al. EPHA2 Blockade Overcomes Acquired Resistance to EGFR Kinase Inhibitors in Lung Cancer. Cancer Res. 2016;76:305-18 pubmed publisher
    ..Here we found that EPHA2 is overexpressed in EGFR TKI-resistant tumor cells...
  57. Son A, Sheleg M, Cooper M, Sun Y, Kleiman N, Zhou R. Formation of persistent hyperplastic primary vitreous in ephrin-A5-/- mice. Invest Ophthalmol Vis Sci. 2014;55:1594-606 pubmed publisher
    ..Ephrin-A5 is a critical factor that regulates primary vitreous regression. ..
  58. Jiang H, Li X, Zhang X, Liu Y, Huang S, Wang X. EphA2 knockdown attenuates atherosclerotic lesion development in ApoE(-/-) mice. Cardiovasc Pathol. 2014;23:169-74 pubmed publisher
    ..b>EphA2 receptor activation promotes the endothelial cell inflammatory response, and its expression is increased in the ..
  59. Luukko K, Løes S, Kvinnsland I, Kettunen P. Expression of ephrin-A ligands and EphA receptors in the developing mouse tooth and its supporting tissues. Cell Tissue Res. 2005;319:143-52 pubmed
    ..roles of the ephrin-Eph system in tooth formation, we studied the cellular mRNA expression of Ephrin-A1-A5 and EphA2, EphA3, EphA4, EphA7, and EphA8 receptors during embryonic histomorphogenesis of the mouse first molar (embryonic ..
  60. Agrawal P, Wang M, Kim S, Lewis A, Bush J. Embryonic expression of EphA receptor genes in mice supports their candidacy for involvement in cleft lip and palate. Dev Dyn. 2014;243:1470-6 pubmed publisher
    ..Together, these results are consistent with the hypothesis that mutations in EPHA family genes may cause CL/P and also suggest that functional redundancy between family members may be at play. ..
  61. Xavier G, Miletich I, Cobourne M. Ephrin Ligands and Eph Receptors Show Regionally Restricted Expression in the Developing Palate and Tongue. Front Physiol. 2016;7:60 pubmed publisher
    ..Numerous Eph transcripts were also identified during tongue development. In particular, EphA1 and EphA2 demonstrated a highly restricted and specific expression in the tongue epithelium at all stages examined, whereas ..
  62. Rogers J, Ciossek T, Menzel P, Pasquale E. Eph receptors and ephrins demarcate cerebellar lobules before and during their formation. Mech Dev. 1999;87:119-28 pubmed
    ..These expression patterns define previously unknown developmental units and suggest that Eph family proteins may contribute to cerebellar morphogenesis. ..
  63. Cesa R, Premoselli F, Renna A, Ethell I, Pasquale E, Strata P. Eph receptors are involved in the activity-dependent synaptic wiring in the mouse cerebellar cortex. PLoS ONE. 2011;6:e19160 pubmed publisher
    ..Such repression is necessary to maintain the correct architecture of the cerebellar cortex. ..
  64. Shi X, Hapiak V, Zheng J, Muller Greven J, Bowman D, Lingerak R, et al. A role of the SAM domain in EphA2 receptor activation. Sci Rep. 2017;7:45084 pubmed publisher
    ..report on a combined cell biology and quantitative fluorescence study to investigate the role of the SAM domain in EphA2 function...
  65. Pickles J. Expression of Ephs and ephrins in developing mouse inner ear. Hear Res. 2003;178:44-51 pubmed
    ..The results suggest that the Ephs and ephrins are likely to play a part in the differentiation of the structures of the inner ear, and show which Ephs and ephrins are most likely to play important roles in the different structures. ..
  66. Ieguchi K, Tomita T, Omori T, Komatsu A, Deguchi A, Masuda J, et al. ADAM12-cleaved ephrin-A1 contributes to lung metastasis. Oncogene. 2014;33:2179-90 pubmed publisher
    ..Depletion of soluble ephrin-A1 by its neutralizing antibody significantly inhibited lung metastasis. ..
  67. Kaplan N, Fatima A, Peng H, Bryar P, Lavker R, Getsios S. EphA2/Ephrin-A1 signaling complexes restrict corneal epithelial cell migration. Invest Ophthalmol Vis Sci. 2012;53:936-45 pubmed publisher
    Eph/ephrin signaling proteins are present in the corneal epithelium, where their function remains unknown. The authors examined the role of the EphA2 receptor and ephrin-A1 ligand in human corneal epithelial cell migration.
  68. North H, Zhao X, Kolk S, Clifford M, Ziskind D, Donoghue M. Promotion of proliferation in the developing cerebral cortex by EphA4 forward signaling. Development. 2009;136:2467-76 pubmed publisher
    ..Furthermore, overexpression of ephrin B1 stimulated cell division of neighboring cells, supporting the hypothesis that ephrin B1-initiated forward signaling of EphA4 promotes cortical cell division. ..
  69. Niederreither K, Vermot J, Le Roux I, Schuhbaur B, Chambon P, Dolle P. The regional pattern of retinoic acid synthesis by RALDH2 is essential for the development of posterior pharyngeal arches and the enteric nervous system. Development. 2003;130:2525-34 pubmed
    ..Thus, RALDH2 plays a crucial role in producing RA required for pharyngeal development, and RA is one of the diffusible mesodermal signals that pattern the pharyngeal endoderm. ..
  70. Sulman E, Tang X, Allen C, Biegel J, Pleasure D, Brodeur G, et al. ECK, a human EPH-related gene, maps to 1p36.1, a common region of alteration in human cancers. Genomics. 1997;40:371-4 pubmed
    Mouse eck, a member of the EPH gene family, has been mapped to mouse chromosome 4...
  71. Freywald A, Sharfe N, Miller C, Rashotte C, Roifman C. EphA receptors inhibit anti-CD3-induced apoptosis in thymocytes. J Immunol. 2006;176:4066-74 pubmed
    ..Our findings suggest that EphA receptor activation is antithetical to TCR signaling in thymocytes, and that the level of engagement by ephrin-A proteins on thymic APCs regulates thymocyte selection. ..
  72. Konda N, Saeki N, Nishino S, Ogawa K. Truncated EphA2 likely potentiates cell adhesion via integrins as well as infiltration and/or lodgment of a monocyte/macrophage cell line in the red pulp and marginal zone of the mouse spleen, where ephrin-A1 is prominently expressed in the vasculatu. Histochem Cell Biol. 2017;147:317-339 pubmed publisher
    We previously established a J774.1 monocyte/macrophage subline expressing a truncated EphA2 construct lacking the kinase domain...
  73. Gilardi Hebenstreit P, Nieto M, Frain M, Mattei M, Chestier A, Wilkinson D, et al. An Eph-related receptor protein tyrosine kinase gene segmentally expressed in the developing mouse hindbrain. Oncogene. 1992;7:2499-506 pubmed
    ..These data are consistent with a role of the Sek gene product in a signal transduction process involved in pattern formation in the hindbrain. ..
  74. Mori T, Wanaka A, Taguchi A, Matsumoto K, Tohyama M. Differential expressions of the eph family of receptor tyrosine kinase genes (sek, elk, eck) in the developing nervous system of the mouse. Brain Res Mol Brain Res. 1995;29:325-35 pubmed
    ..examine the roles of the eph subfamily of receptor tyrosine kinase (RTK), we isolated mouse cDNAs for sek, elk, and eck and localized their mRNAs in the developing mouse, with particular reference to the CNS development, by in situ ..
  75. Nieto M, Gilardi Hebenstreit P, Charnay P, Wilkinson D. A receptor protein tyrosine kinase implicated in the segmental patterning of the hindbrain and mesoderm. Development. 1992;116:1137-50 pubmed
    ..These data suggest that despite the morphological differences in the segmentation of the hindbrain and mesoderm, Sek is involved in the segmental patterning of both of these tissues. ..