Genomes and Genes
Gene Symbol: Epb41l2
Description: erythrocyte membrane protein band 4.1 like 2
Alias: 4.1G, AW555191, D10Ertd398e, Epb4.1l2, NBL2, band 4.1-like protein 2, erythrocyte membrane protein band 4.1-like 2 retinal, erythrocyte protein band 4.1 like 2, erythrocyte protein band 4.1l2 long, erythrocyte protein band 4.1l2 middle, generally expressed protein 4.1
- Chen J, Terada N, Ohno N, Saitoh S, Saitoh Y, Ohno S. Immunolocalization of membrane skeletal protein, 4.1G, in enteric glial cells in the mouse large intestine. Neurosci Lett. 2011;488:193-8 pubmed publisher..1G was detected along cell membranes of enteric glial cells and their processes surrounding axons. These indicate that 4.1G may have some roles in adhesion and/or signal transduction in unmylinated PNS nerve fibers. ..
- Gibson A, Li X, Wu J, Baskin J, Raman C, Edberg J, et al. Serine phosphorylation of Fc?RI cytoplasmic domain directs lipid raft localization and interaction with protein 4.1G. J Leukoc Biol. 2012;91:97-103 pubmed publisher..With the use of the yeast two-hybrid system, we and others have shown that Fc?RI interacts with protein 4.1G (EPB41L2). Our mutational analyses identified two required 4...
- Kontrogianni Konstantopoulos A, Frye C, Benz E, Huang S. The prototypical 4.1R-10-kDa domain and the 4.1g-10-kDa paralog mediate fodrin-actin complex formation. J Biol Chem. 2001;276:20679-87 pubmed..1G are distributed underneath the plasma membrane in PC12 cells. Collectively, these observations suggest that brain 4.1R and 4.1G may modulate the membrane mechanical properties of neuronal cells by promoting fodrin/actin association. ..
- Chen L, Wang T, Wang Y, Zhang J, Qi Y, Weng H, et al. Protein 4.1G Regulates Cell Adhesion, Spreading, and Migration of Mouse Embryonic Fibroblasts through the Î²1 Integrin Pathway. J Biol Chem. 2016;291:2170-80 pubmed publisher..These findings identified a novel role of 4.1G in cell adhesion, spreading, and migration in MEF cells by modulating the surface expression of Î²1 integrin and subsequent downstream signal transduction. ..
- Nakahata N, Saito M. [Regulation of G protein-coupled receptor function by its binding proteins]. Yakugaku Zasshi. 2007;127:3-14 pubmed..In conclusion, the proteins bound to GPCRs may regulate the intracellular traffic of GPCRs. ..
- Taylor Harris P, Keating L, Maggs A, Phillips G, Birks E, Franklin R, et al. Cardiac muscle cell cytoskeletal protein 4.1: analysis of transcripts and subcellular location--relevance to membrane integrity, microstructure, and possible role in heart failure. Mamm Genome. 2005;16:137-51 pubmed..Four genes, EPB41, EPB41L1, EPB41L2, and EPB41L3 encode proteins 4.1R, 4.1N, 4.1G, and 4.1B, respectively. All are extensively spliced...
- Ivanovic A, Horresh I, Golan N, Spiegel I, Sabanay H, Frechter S, et al. The cytoskeletal adapter protein 4.1G organizes the internodes in peripheral myelinated nerves. J Cell Biol. 2012;196:337-44 pubmed publisher..These findings suggest that protein 4.1G contributes to the organization of the internodal axolemma by targeting and/or maintaining glial transmembrane proteins along the axoglial interface. ..
- Takeuchi K, Kawashima A, Nagafuchi A, Tsukita S. Structural diversity of band 4.1 superfamily members. J Cell Sci. 1994;107 ( Pt 7):1921-8 pubmed..In this study, we describe the initial characterization of these new members and discuss the evolution of the band 4.1 superfamily. ..
- Terada N, Saitoh Y, Ohno N, Komada M, Yamauchi J, Ohno S. Involvement of Src in the membrane skeletal complex, MPP6-4.1G, in Schmidt-Lanterman incisures of mouse myelinated nerve fibers in PNS. Histochem Cell Biol. 2013;140:213-22 pubmed publisher..An immunoprecipitation study revealed Src interaction with MPP6. These findings indicate that the Src-MPP6-4.1G protein complex in SLIs has a role in signal transduction in the PNS. ..
- Cheng C, Molday R. Interaction of 4.1G and cGMP-gated channels in rod photoreceptor outer segments. J Cell Sci. 2013;126:5725-34 pubmed publisher..Our studies indicate that 4.1G interacts with a subset of CNG channels in the ROS and implicate this protein-protein interaction in organizing the spatial arrangement of CNG channels in the plasma membrane of outer segments. ..
- Sanuki R, Watanabe S, Sugita Y, Irie S, Kozuka T, Shimada M, et al. Protein-4.1G-Mediated Membrane Trafficking Is Essential for Correct Rod Synaptic Location in the Retina and for Normal Visual Function. Cell Rep. 2015;: pubmed publisher..Taken together, the data in this study provide insight into the mechanism and importance of proper synapse location in neural circuit formation. ..
- Legendre K, Safieddine S, Küssel Andermann P, Petit C, El Amraoui A. alphaII-betaV spectrin bridges the plasma membrane and cortical lattice in the lateral wall of the auditory outer hair cells. J Cell Sci. 2008;121:3347-56 pubmed publisher..We conclude that the cortical network involved in the sound-induced electromotility of OHCs contains alphaII-betaV spectrin, and not the conventional alphaII-betaII spectrin. ..
- Saitoh Y, Ohno N, Yamauchi J, Sakamoto T, Terada N. Deficiency of a membrane skeletal protein, 4.1G, results in myelin abnormalities in the peripheral nervous system. Histochem Cell Biol. 2017;148:597-606 pubmed publisher..1G-/- sciatic nerves, as well as the interaction of MPP6 and Lin7 with immunoprecipitation. Thus, we herein propose 4.1G functions as a signal for proper formation of myelin in PNS. ..