Gene Symbol: Epb41l2
Description: erythrocyte membrane protein band 4.1 like 2
Alias: 4.1G, AW555191, D10Ertd398e, Epb4.1l2, NBL2, band 4.1-like protein 2, erythrocyte membrane protein band 4.1-like 2 retinal, erythrocyte protein band 4.1 like 2, erythrocyte protein band 4.1l2 long, erythrocyte protein band 4.1l2 middle, generally expressed protein 4.1
Species: mouse
Products:     Epb41l2

Top Publications

  1. Terada N, Saitoh Y, Ohno N, Komada M, Saitoh S, Peles E, et al. Essential function of protein 4.1G in targeting of membrane protein palmitoylated 6 into Schmidt-Lanterman incisures in myelinated nerves. Mol Cell Biol. 2012;32:199-205 pubmed publisher
    ..1G. These results indicate that 4.1G has a specific role in the targeting of MPP6 to the SLI and the assembly of these subcellular structures. ..
  2. Ohno N, Terada N, Yamakawa H, Komada M, Ohara O, Trapp B, et al. Expression of protein 4.1G in Schwann cells of the peripheral nervous system. J Neurosci Res. 2006;84:568-77 pubmed
    ..These data support the concept that 4.1G plays an important role in the membrane expansion and specialization that occurs during formation and maintenance of myelin internodes in the peripheral nervous system. ..
  3. Yang S, Weng H, Chen L, Guo X, Parra M, CONBOY J, et al. Lack of protein 4.1G causes altered expression and localization of the cell adhesion molecule nectin-like 4 in testis and can cause male infertility. Mol Cell Biol. 2011;31:2276-86 pubmed publisher
    ..Additionally, the finding that infertility is present in B6-129 but not on the B6 background suggests the presence of a major modifier gene(s) that influences 4.1G function and is associated with male infertility. ..
  4. Terada N, Ohno N, Saitoh S, Saitoh Y, Komada M, Kubota H, et al. Involvement of a membrane skeletal protein, 4.1G, for Sertoli/germ cell interaction. Reproduction. 2010;139:883-92 pubmed publisher
    We previously reported that a membrane skeletal protein, 4.1G (also known as EPB41L2), is immunolocalized in mouse seminiferous tubules. In this study, the 4...
  5. Wozny C, Breustedt J, Wolk F, Varoqueaux F, Boretius S, Zivkovic A, et al. The function of glutamatergic synapses is not perturbed by severe knockdown of 4.1N and 4.1G expression. J Cell Sci. 2009;122:735-44 pubmed publisher
    ..Our study indicates that 4.1G and 4.1N do not have a crucial role in glutamatergic synaptic transmission and the induction and maintenance of long-term plastic changes in synaptic efficacy. ..
  6. Walensky L, Gascard P, Fields M, Blackshaw S, Conboy J, Mohandas N, et al. The 13-kD FK506 binding protein, FKBP13, interacts with a novel homologue of the erythrocyte membrane cytoskeletal protein 4.1. J Cell Biol. 1998;141:143-53 pubmed
    ..1 (4.1R) in ghosts, inside-out vesicles, and Triton shell preparations. The identification of FKBP13 in erythrocytes, which lack ER, suggests that FKBP13 may additionally function as a component of membrane cytoskeletal scaffolds. ..
  7. Jung Y, McCarty J. Band 4.1 proteins regulate integrin-dependent cell spreading. Biochem Biophys Res Commun. 2012;426:578-84 pubmed publisher
    ..1 family members. Collectively, these findings reveal that Band 4.1 proteins are important intracellular components for integrin-mediated cell spreading. ..
  8. Pinder J, Taylor Harris P, Bennett P, Carter E, Hayes N, King M, et al. Isoforms of protein 4.1 are differentially distributed in heart muscle cells: relation of 4.1R and 4.1G to components of the Ca2+ homeostasis system. Exp Cell Res. 2012;318:1467-79 pubmed publisher
    ..We conclude that isoforms of 4.1 proteins are differentially compartmentalised in the heart, and that they form specific complexes with proteins central to cardiomyocyte Ca(2+) metabolism...
  9. Okumura K, Mochizuki E, Yokohama M, Yamakawa H, Shitara H, Mburu P, et al. Protein 4.1 expression in the developing hair cells of the mouse inner ear. Brain Res. 2010;1307:53-62 pubmed publisher
    ..1 family members play important roles in the development and maintenance of the inner ear hair cells, and that 4.1B may be a member of the myosin XV-whirlin complex that is important for stereocilia maturation. ..

More Information


  1. Chen J, Terada N, Ohno N, Saitoh S, Saitoh Y, Ohno S. Immunolocalization of membrane skeletal protein, 4.1G, in enteric glial cells in the mouse large intestine. Neurosci Lett. 2011;488:193-8 pubmed publisher
    ..1G was detected along cell membranes of enteric glial cells and their processes surrounding axons. These indicate that 4.1G may have some roles in adhesion and/or signal transduction in unmylinated PNS nerve fibers. ..
  2. Gibson A, Li X, Wu J, Baskin J, Raman C, Edberg J, et al. Serine phosphorylation of Fc?RI cytoplasmic domain directs lipid raft localization and interaction with protein 4.1G. J Leukoc Biol. 2012;91:97-103 pubmed publisher
    ..With the use of the yeast two-hybrid system, we and others have shown that Fc?RI interacts with protein 4.1G (EPB41L2). Our mutational analyses identified two required 4...
  3. Kontrogianni Konstantopoulos A, Frye C, Benz E, Huang S. The prototypical 4.1R-10-kDa domain and the 4.1g-10-kDa paralog mediate fodrin-actin complex formation. J Biol Chem. 2001;276:20679-87 pubmed
    ..1G are distributed underneath the plasma membrane in PC12 cells. Collectively, these observations suggest that brain 4.1R and 4.1G may modulate the membrane mechanical properties of neuronal cells by promoting fodrin/actin association. ..
  4. Chen L, Wang T, Wang Y, Zhang J, Qi Y, Weng H, et al. Protein 4.1G Regulates Cell Adhesion, Spreading, and Migration of Mouse Embryonic Fibroblasts through the β1 Integrin Pathway. J Biol Chem. 2016;291:2170-80 pubmed publisher
    ..These findings identified a novel role of 4.1G in cell adhesion, spreading, and migration in MEF cells by modulating the surface expression of β1 integrin and subsequent downstream signal transduction. ..
  5. Nakahata N, Saito M. [Regulation of G protein-coupled receptor function by its binding proteins]. Yakugaku Zasshi. 2007;127:3-14 pubmed
    ..In conclusion, the proteins bound to GPCRs may regulate the intracellular traffic of GPCRs. ..
  6. Taylor Harris P, Keating L, Maggs A, Phillips G, Birks E, Franklin R, et al. Cardiac muscle cell cytoskeletal protein 4.1: analysis of transcripts and subcellular location--relevance to membrane integrity, microstructure, and possible role in heart failure. Mamm Genome. 2005;16:137-51 pubmed
    ..Four genes, EPB41, EPB41L1, EPB41L2, and EPB41L3 encode proteins 4.1R, 4.1N, 4.1G, and 4.1B, respectively. All are extensively spliced...
  7. Ivanovic A, Horresh I, Golan N, Spiegel I, Sabanay H, Frechter S, et al. The cytoskeletal adapter protein 4.1G organizes the internodes in peripheral myelinated nerves. J Cell Biol. 2012;196:337-44 pubmed publisher
    ..These findings suggest that protein 4.1G contributes to the organization of the internodal axolemma by targeting and/or maintaining glial transmembrane proteins along the axoglial interface. ..
  8. Takeuchi K, Kawashima A, Nagafuchi A, Tsukita S. Structural diversity of band 4.1 superfamily members. J Cell Sci. 1994;107 ( Pt 7):1921-8 pubmed
    ..In this study, we describe the initial characterization of these new members and discuss the evolution of the band 4.1 superfamily. ..
  9. Terada N, Saitoh Y, Ohno N, Komada M, Yamauchi J, Ohno S. Involvement of Src in the membrane skeletal complex, MPP6-4.1G, in Schmidt-Lanterman incisures of mouse myelinated nerve fibers in PNS. Histochem Cell Biol. 2013;140:213-22 pubmed publisher
    ..An immunoprecipitation study revealed Src interaction with MPP6. These findings indicate that the Src-MPP6-4.1G protein complex in SLIs has a role in signal transduction in the PNS. ..
  10. Cheng C, Molday R. Interaction of 4.1G and cGMP-gated channels in rod photoreceptor outer segments. J Cell Sci. 2013;126:5725-34 pubmed publisher
    ..Our studies indicate that 4.1G interacts with a subset of CNG channels in the ROS and implicate this protein-protein interaction in organizing the spatial arrangement of CNG channels in the plasma membrane of outer segments. ..
  11. Sanuki R, Watanabe S, Sugita Y, Irie S, Kozuka T, Shimada M, et al. Protein-4.1G-Mediated Membrane Trafficking Is Essential for Correct Rod Synaptic Location in the Retina and for Normal Visual Function. Cell Rep. 2015;: pubmed publisher
    ..Taken together, the data in this study provide insight into the mechanism and importance of proper synapse location in neural circuit formation. ..
  12. Legendre K, Safieddine S, Küssel Andermann P, Petit C, El Amraoui A. alphaII-betaV spectrin bridges the plasma membrane and cortical lattice in the lateral wall of the auditory outer hair cells. J Cell Sci. 2008;121:3347-56 pubmed publisher
    ..We conclude that the cortical network involved in the sound-induced electromotility of OHCs contains alphaII-betaV spectrin, and not the conventional alphaII-betaII spectrin. ..
  13. Saitoh Y, Ohno N, Yamauchi J, Sakamoto T, Terada N. Deficiency of a membrane skeletal protein, 4.1G, results in myelin abnormalities in the peripheral nervous system. Histochem Cell Biol. 2017;148:597-606 pubmed publisher
    ..1G-/- sciatic nerves, as well as the interaction of MPP6 and Lin7 with immunoprecipitation. Thus, we herein propose 4.1G functions as a signal for proper formation of myelin in PNS. ..