Eos

Summary

Gene Symbol: Eos
Description: IKAROS family zinc finger 4
Alias: A630026H08Rik, Eos, Zfpn1a4, Znfn1a4, zinc finger protein Eos, ikaros family zinc finger protein 4, zinc finger protein, subfamily 1A, 4 (Eos)
Species: mouse
Products:     Eos

Top Publications

  1. Honma Y, Kiyosawa H, Mori T, Oguri A, Nikaido T, Kanazawa K, et al. Eos: a novel member of the Ikaros gene family expressed predominantly in the developing nervous system. FEBS Lett. 1999;447:76-80 pubmed
    ..This gene, which we named Eos, was expressed predominantly in the developing central and peripheral nervous system...
  2. Perdomo J, Crossley M. The Ikaros family protein Eos associates with C-terminal-binding protein corepressors. Eur J Biochem. 2002;269:5885-92 pubmed
    b>Eos is a zinc finger transcription factor of the Ikaros family. It binds typical GGGAA Ikaros recognition sites in DNA and functions as a transcriptional repressor...
  3. Bottardi S, Mavoungou L, Bourgoin V, Mashtalir N, Affar E, Milot E. Direct protein interactions are responsible for Ikaros-GATA and Ikaros-Cdk9 cooperativeness in hematopoietic cells. Mol Cell Biol. 2013;33:3064-76 pubmed publisher
    ..Thus, Ik is central to the Ik-GATA-Cdk9 regulatory network, which is broadly utilized for gene regulation in hematopoietic cells. ..
  4. RIEDER S, Metidji A, Glass D, Thornton A, Ikeda T, Morgan B, et al. Eos Is Redundant for Regulatory T Cell Function but Plays an Important Role in IL-2 and Th17 Production by CD4+ Conventional T Cells. J Immunol. 2015;195:553-63 pubmed publisher
    b>Eos belongs to the Ikaros family of transcription factors. It was reported to be a regulatory T cell (Treg) signature gene, to play a critical role in Treg suppressor functions, and to maintain Treg stability...
  5. Arenzana T, Schjerven H, Smale S. Regulation of gene expression dynamics during developmental transitions by the Ikaros transcription factor. Genes Dev. 2015;29:1801-16 pubmed publisher
    ..Instead, a primary function may be to sharpen the dynamic range of gene expression changes during developmental transitions via atypical molecular mechanisms that remain undefined. ..
  6. Bettini M, Pan F, Bettini M, Finkelstein D, Rehg J, Floess S, et al. Loss of epigenetic modification driven by the Foxp3 transcription factor leads to regulatory T cell insufficiency. Immunity. 2012;36:717-30 pubmed publisher
    ..with the histone acetyltransferase Tip60, the histone deacetylase HDAC7, and the Ikaros family zinc finger 4, Eos, which led to reduced Foxp3 acetylation and enhanced K48-linked polyubiquitylation...
  7. Yeung F, Chung E, Guess M, Bell M, Leinwand L. Myh7b/miR-499 gene expression is transcriptionally regulated by MRFs and Eos. Nucleic Acids Res. 2012;40:7303-18 pubmed publisher
    ..regulatory factors, MyoD, Myf5 and Myogenin, bind to the E-box, while a lymphoid transcription factor, Ikaros 4 (Eos), binds to the Ikaros motif...
  8. Alsiö J, Tarchini B, Cayouette M, Livesey F. Ikaros promotes early-born neuronal fates in the cerebral cortex. Proc Natl Acad Sci U S A. 2013;110:E716-25 pubmed publisher
    ..These data suggest that Ikaros plays a similar role in regulating early temporal fates in the mammalian cerebral cortex as Ikaros/Hunchback proteins do in the Drosophila nerve cord. ..
  9. Liu S, Jiang S, Li C, Zhang B, Li Q. miR-17-92 cluster targets phosphatase and tensin homology and Ikaros Family Zinc Finger 4 to promote TH17-mediated inflammation. J Biol Chem. 2014;289:12446-56 pubmed publisher
    ..By establishing the miR-17-92 cluster as a key driver of TH17 responses, our data identify this miRNA cluster as a potential therapeutic target for the clinical intervention of multiple sclerosis. ..

More Information

Publications14

  1. Elliott J, Jolicoeur C, Ramamurthy V, Cayouette M. Ikaros confers early temporal competence to mouse retinal progenitor cells. Neuron. 2008;60:26-39 pubmed publisher
  2. Pan F, Yu H, Dang E, Barbi J, Pan X, Grosso J, et al. Eos mediates Foxp3-dependent gene silencing in CD4+ regulatory T cells. Science. 2009;325:1142-6 pubmed publisher
    ..We identified Eos, a zinc-finger transcription factor of the Ikaros family, as a critical mediator of Foxp3-dependent gene silencing ..
  3. Hu R, Sharma S, Bronisz A, Srinivasan R, Sankar U, Ostrowski M. Eos, MITF, and PU.1 recruit corepressors to osteoclast-specific genes in committed myeloid progenitors. Mol Cell Biol. 2007;27:4018-27 pubmed
    ..The direct interaction of MITF and PU.1 with the zinc finger protein Eos, an Ikaros family member, was necessary for repression of Ctsk and Acp5...
  4. Sharma M, Huang L, Choi J, Lee E, Wilson J, Lemos H, et al. An inherently bifunctional subset of Foxp3+ T helper cells is controlled by the transcription factor eos. Immunity. 2013;38:998-1012 pubmed publisher
    ..We show that reprogramming is controlled by downregulation of the transcription factor Eos (Ikzf4), an obligate corepressor for Foxp3...
  5. Yang H, Barbi J, Wu C, Zheng Y, Vignali P, Wu X, et al. MicroRNA-17 Modulates Regulatory T Cell Function by Targeting Co-regulators of the Foxp3 Transcription Factor. Immunity. 2016;45:83-93 pubmed publisher
    ..The Treg cell transcription factor Foxp3 works in concert with other co-regulatory molecules, including Eos, to determine the transcriptional signature and characteristic suppressive phenotype of Treg cells...