Eng

Summary

Gene Symbol: Eng
Description: endoglin
Alias: AI528660, AI662476, CD105, Endo, S-endoglin, endoglin, cell surface MJ7/18 antigen, transmembrane glycoprotein
Species: mouse
Products:     Eng

Top Publications

  1. Xu B, Wu Y, Huey M, Arthur H, Marchuk D, Hashimoto T, et al. Vascular endothelial growth factor induces abnormal microvasculature in the endoglin heterozygous mouse brain. J Cereb Blood Flow Metab. 2004;24:237-44 pubmed
    ..HHT), associated with brain arteriovenous malformations, is caused by a loss of function mutation in either the endoglin (HHT1) or activin receptor-like kinase 1 gene (ALK-1, HHT2)...
  2. Lebrin F, Goumans M, Jonker L, Carvalho R, Valdimarsdottir G, Thorikay M, et al. Endoglin promotes endothelial cell proliferation and TGF-beta/ALK1 signal transduction. EMBO J. 2004;23:4018-28 pubmed
    b>Endoglin is a transmembrane accessory receptor for transforming growth factor-beta (TGF-beta) that is predominantly expressed on proliferating endothelial cells in culture and on angiogenic blood vessels in vivo...
  3. Van Laake L, van den Driesche S, Post S, Feijen A, Jansen M, Driessens M, et al. Endoglin has a crucial role in blood cell-mediated vascular repair. Circulation. 2006;114:2288-97 pubmed
    b>Endoglin, an accessory receptor for transforming growth factor-beta in vascular endothelial cells, is essential for angiogenesis during mouse development...
  4. Blanco F, Grande M, Langa C, Oujo B, Velasco S, Rodriguez Barbero A, et al. S-endoglin expression is induced in senescent endothelial cells and contributes to vascular pathology. Circ Res. 2008;103:1383-92 pubmed publisher
    ..Here, we have analyzed the expression, during EC senescence, of 2 different isoforms (L, long; S, short) of endoglin, an auxiliary transforming growth factor (TGF)-beta receptor involved in vascular remodeling and angiogenesis...
  5. Lee N, Ray B, How T, Blobe G. Endoglin promotes transforming growth factor beta-mediated Smad 1/5/8 signaling and inhibits endothelial cell migration through its association with GIPC. J Biol Chem. 2008;283:32527-33 pubmed publisher
    ..b>Endoglin is a co-receptor predominantly expressed in endothelial cells that participates in TGFbeta-mediated signaling ..
  6. Ray B, Lee N, How T, Blobe G. ALK5 phosphorylation of the endoglin cytoplasmic domain regulates Smad1/5/8 signaling and endothelial cell migration. Carcinogenesis. 2010;31:435-41 pubmed publisher
    b>Endoglin, an endothelial cell-specific transforming growth factor-beta (TGF-beta) superfamily coreceptor, has an essential role in angiogenesis...
  7. Lee N, Blobe G. The interaction of endoglin with beta-arrestin2 regulates transforming growth factor-beta-mediated ERK activation and migration in endothelial cells. J Biol Chem. 2007;282:21507-17 pubmed
    ..pathways is further regulated in endothelial cells by the endothelial specific TGF-beta superfamily co-receptor, endoglin. The importance of endoglin, ALK-1, and ALK-5 in endothelial biology is underscored by the embryonic lethal ..
  8. Jerkic M, Rodriguez Barbero A, Prieto M, Toporsian M, Pericacho M, Rivas Elena J, et al. Reduced angiogenic responses in adult Endoglin heterozygous mice. Cardiovasc Res. 2006;69:845-54 pubmed
    To determine if angiogenesis is altered in adult Endoglin heterozygous (Eng(+/-)) mice, the animal model for the vascular disorder hereditary hemorrhagic telangiectasia type 1 (HHT1)...
  9. Mouta Bellum C, Kirov A, Miceli Libby L, Mancini M, Petrova T, Liaw L, et al. Organ-specific lymphangiectasia, arrested lymphatic sprouting, and maturation defects resulting from gene-targeting of the PI3K regulatory isoforms p85alpha, p55alpha, and p50alpha. Dev Dyn. 2009;238:2670-9 pubmed publisher
    ..Only the gut showed lymphangiectasia, lymphatic up-regulation of the transforming growth factor-beta co-receptor endoglin, and reduced levels of mature vascular endothelial growth factor-C protein...

More Information

Publications74

  1. Jonker L, Arthur H. Endoglin expression in early development is associated with vasculogenesis and angiogenesis. Mech Dev. 2002;110:193-6 pubmed
    b>Endoglin is an auxiliary receptor for the transforming growth factor-beta family of cytokines and is required for angiogenesis and heart development...
  2. Torsney E, Charlton R, Diamond A, Burn J, Soames J, Arthur H. Mouse model for hereditary hemorrhagic telangiectasia has a generalized vascular abnormality. Circulation. 2003;107:1653-7 pubmed
    Mutations in endoglin or activin like kinase-1, both involved in the endothelial transforming growth factor-beta signaling pathway, cause the autosomal dominant bleeding disorder hereditary hemorrhagic telangiectasia...
  3. Sorensen L, Brooke B, Li D, Urness L. Loss of distinct arterial and venous boundaries in mice lacking endoglin, a vascular-specific TGFbeta coreceptor. Dev Biol. 2003;261:235-50 pubmed
    ..The genes implicated in this disease, ALK1 and endoglin, may be involved in defining the fundamental boundaries between arteries and veins...
  4. Jerkic M, Rivas Elena J, Prieto M, Carron R, Sanz Rodriguez F, Perez Barriocanal F, et al. Endoglin regulates nitric oxide-dependent vasodilatation. FASEB J. 2004;18:609-11 pubmed
    b>Endoglin is a membrane glycoprotein that plays an important role in cardiovascular development and angiogenesis...
  5. Jerkic M, Rivas Elena J, Santibanez J, Prieto M, Rodriguez Barbero A, Perez Barriocanal F, et al. Endoglin regulates cyclooxygenase-2 expression and activity. Circ Res. 2006;99:248-56 pubmed
    The endoglin heterozygous (Eng(+/-)) mouse, which serves as a model of hereditary hemorrhagic telangiectasia (HHT), was shown to express reduced levels of endothelial NO synthase (eNOS) with impaired activity...
  6. Pece Barbara N, Vera S, Kathirkamathamby K, Liebner S, Di Guglielmo G, Dejana E, et al. Endoglin null endothelial cells proliferate faster and are more responsive to transforming growth factor beta1 with higher affinity receptors and an activated Alk1 pathway. J Biol Chem. 2005;280:27800-8 pubmed
    b>Endoglin is an accessory receptor for transforming growth factor beta (TGFbeta) in endothelial cells, essential for vascular development...
  7. Toporsian M, Gros R, Kabir M, Vera S, Govindaraju K, Eidelman D, et al. A role for endoglin in coupling eNOS activity and regulating vascular tone revealed in hereditary hemorrhagic telangiectasia. Circ Res. 2005;96:684-92 pubmed
    ..Hereditary hemorrhagic telangiectasia type 1 (HHT1) is a vascular disorder associated with ENDOGLIN (ENG) haploinsufficiency and characterized by venous dilatations, focal loss of capillaries, and arteriovenous ..
  8. Bourdeau A, Faughnan M, McDonald M, Paterson A, Wanless I, Letarte M. Potential role of modifier genes influencing transforming growth factor-beta1 levels in the development of vascular defects in endoglin heterozygous mice with hereditary hemorrhagic telangiectasia. Am J Pathol. 2001;158:2011-20 pubmed
    ..hemorrhagic telangiectasia (HHT) is an autosomal dominant disorder because of mutations in the genes coding for endoglin (HHT1) or ALK-1 (HHT2)...
  9. Arthur H, Ure J, Smith A, Renforth G, Wilson D, Torsney E, et al. Endoglin, an ancillary TGFbeta receptor, is required for extraembryonic angiogenesis and plays a key role in heart development. Dev Biol. 2000;217:42-53 pubmed
    b>Endoglin (CD105) is expressed on the surface of endothelial and haematopoietic cells in mammals and binds TGFbeta isoforms 1 and 3 in combination with the signaling complex of TGFbeta receptors types I and II...
  10. Li D, Sorensen L, Brooke B, Urness L, Davis E, Taylor D, et al. Defective angiogenesis in mice lacking endoglin. Science. 1999;284:1534-7 pubmed
    b>Endoglin is a transforming growth factor-beta (TGF-beta) binding protein expressed on the surface of endothelial cells...
  11. Mahmoud M, Allinson K, Zhai Z, Oakenfull R, Ghandi P, Adams R, et al. Pathogenesis of arteriovenous malformations in the absence of endoglin. Circ Res. 2010;106:1425-33 pubmed publisher
    ..As most HHT patients have mutations in ENG (endoglin) or ACVRL1 (activin receptor-like kinase 1), a better understanding of the role of these genes in vascular ..
  12. Nomura Kitabayashi A, Anderson G, Sleep G, Mena J, Karabegovic A, Karamath S, et al. Endoglin is dispensable for angiogenesis, but required for endocardial cushion formation in the midgestation mouse embryo. Dev Biol. 2009;335:66-77 pubmed publisher
    ..b>Endoglin is a transmembrane receptor for members of the TGF-beta superfamily that is expressed on endothelial cells from ..
  13. Santibanez J, Letamendia A, Perez Barriocanal F, Silvestri C, Saura M, Vary C, et al. Endoglin increases eNOS expression by modulating Smad2 protein levels and Smad2-dependent TGF-beta signaling. J Cell Physiol. 2007;210:456-68 pubmed
    ..b>Endoglin is a component of the transforming growth factor beta (TGF-beta) receptor complex present in endothelial cells ..
  14. Carvalho R, Jonker L, Goumans M, Larsson J, Bouwman P, Karlsson S, et al. Defective paracrine signalling by TGFbeta in yolk sac vasculature of endoglin mutant mice: a paradigm for hereditary haemorrhagic telangiectasia. Development. 2004;131:6237-47 pubmed
    ..Germline mutations in one of two different genes, endoglin or ALK1 can cause HHT...
  15. Tevosian S, Deconinck A, Tanaka M, Schinke M, Litovsky S, Izumo S, et al. FOG-2, a cofactor for GATA transcription factors, is essential for heart morphogenesis and development of coronary vessels from epicardium. Cell. 2000;101:729-39 pubmed
    ..Our findings provide the molecular inroad into the induction of coronary vasculature by myocardium in the developing heart. ..
  16. Baik J, Borges L, Magli A, Thatava T, Perlingeiro R. Effect of endoglin overexpression during embryoid body development. Exp Hematol. 2012;40:837-46 pubmed publisher
    Increasing evidence points to endoglin (Eng), an accessory receptor for the transforming growth factor-? superfamily commonly associated with the endothelial lineage, as an important regulator of the hematopoietic lineage...
  17. Allinson K, Carvalho R, van den Brink S, Mummery C, Arthur H. Generation of a floxed allele of the mouse Endoglin gene. Genesis. 2007;45:391-5 pubmed
    b>Endoglin is an auxiliary receptor for TGFbeta signalling. Heterozygous germline Endoglin mutations have been identified in patients with the vascular abnormality, Hereditary Haemorrhagic Telangiectasia...
  18. Park S, Dimaio T, Liu W, Wang S, Sorenson C, Sheibani N. Endoglin regulates the activation and quiescence of endothelium by participating in canonical and non-canonical TGF-? signaling pathways. J Cell Sci. 2013;126:1392-405 pubmed publisher
    b>Endoglin (Eng) is an auxiliary receptor for transforming growth factor-? (TGF?), with important roles in vascular function...
  19. Suzuki Y, Ohga N, Morishita Y, Hida K, Miyazono K, Watabe T. BMP-9 induces proliferation of multiple types of endothelial cells in vitro and in vivo. J Cell Sci. 2010;123:1684-92 pubmed publisher
    ..These findings suggest that BMP-9 signaling activates the endothelium tested in the present study via ALK-1. ..
  20. Scharpfenecker M, Floot B, Russell N, Stewart F. The TGF-? co-receptor endoglin regulates macrophage infiltration and cytokine production in the irradiated mouse kidney. Radiother Oncol. 2012;105:313-20 pubmed publisher
    We previously showed that mice with reduced levels of the transforming growth factor-beta (TGF-?) co-receptor endoglin (Eng(+/-) mice) develop less fibrosis and vascular damage after kidney irradiation than their wild type (Eng(+/+) mice) ..
  21. Santibanez J, Perez Gomez E, Fernandez L A, Garrido Martin E, Carnero A, Malumbres M, et al. The TGF-beta co-receptor endoglin modulates the expression and transforming potential of H-Ras. Carcinogenesis. 2010;31:2145-54 pubmed publisher
    b>Endoglin is a coreceptor for transforming growth factor-? (TGF-?) that acts as a suppressor of malignancy during mouse skin carcinogenesis...
  22. Castonguay R, Werner E, Matthews R, Presman E, Mulivor A, Solban N, et al. Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its orphan domain, inhibits blood vessel formation, and suppresses tumor growth. J Biol Chem. 2011;286:30034-46 pubmed publisher
    b>Endoglin (CD105), a transmembrane protein of the transforming growth factor ? superfamily, plays a crucial role in angiogenesis. Mutations in endoglin result in the vascular defect known as hereditary hemorrhagic telangiectasia (HHT1)...
  23. Perez Gomez E, Villa Morales M, Santos J, Fernandez Piqueras J, Gamallo C, Dotor J, et al. A role for endoglin as a suppressor of malignancy during mouse skin carcinogenesis. Cancer Res. 2007;67:10268-77 pubmed
    b>Endoglin is a membrane glycoprotein that acts as a coreceptor for transforming growth factor-beta. We and others have previously suggested a function of endoglin as a tumor suppressor in epithelial cancer...
  24. Choi E, Walker E, Shen F, Oh S, Arthur H, Young W, et al. Minimal homozygous endothelial deletion of Eng with VEGF stimulation is sufficient to cause cerebrovascular dysplasia in the adult mouse. Cerebrovasc Dis. 2012;33:540-7 pubmed publisher
    ..Hereditary Hemorrhagic Telangiectasia (HHT) patients with haploinsufficiency of endoglin (ENG, HHT1) or activin receptor-like kinase 1 (ALK1, HHT2) have a higher incidence of bAVM than the general ..
  25. Perlingeiro R. Endoglin is required for hemangioblast and early hematopoietic development. Development. 2007;134:3041-8 pubmed
    b>Endoglin (ENG), an ancillary receptor for several members of the transforming growth factor (TGF)-beta superfamily, has a well-studied role in endothelial function...
  26. Zhang L, Magli A, Catanese J, Xu Z, Kyba M, Perlingeiro R. Modulation of TGF-? signaling by endoglin in murine hemangioblast development and primitive hematopoiesis. Blood. 2011;118:88-97 pubmed publisher
    b>Endoglin (Eng), an accessory receptor for the transforming growth factor ? (TGF-?) superfamily, is required for proper hemangioblast and primitive hematopoietic development...
  27. Jerkic M, Peter M, Ardelean D, Fine M, Konerding M, Letarte M. Dextran sulfate sodium leads to chronic colitis and pathological angiogenesis in Endoglin heterozygous mice. Inflamm Bowel Dis. 2010;16:1859-70 pubmed publisher
    ..b>Endoglin is essential for endothelial cell function and physiological angiogenesis...
  28. Ge A, Butcher E. Cloning and expression of a cDNA encoding mouse endoglin, an endothelial cell TGF-beta ligand. Gene. 1994;138:201-6 pubmed
    ..The sequence of a cDNA encoding the cell surface MJ7/18 antigen revealed homology to human endoglin, a homodimeric transforming growth factor-beta (TGF-beta)-binding cell-surface glycoprotein expressed ..
  29. Rossi E, Sanz Rodriguez F, Eleno N, Düwell A, Blanco F, Langa C, et al. Endothelial endoglin is involved in inflammation: role in leukocyte adhesion and transmigration. Blood. 2013;121:403-15 pubmed publisher
    Human endoglin is an RGD-containing transmembrane glycoprotein identified in vascular endothelial cells...
  30. Anderberg C, Cunha S, Zhai Z, Cortez E, Pardali E, Johnson J, et al. Deficiency for endoglin in tumor vasculature weakens the endothelial barrier to metastatic dissemination. J Exp Med. 2013;210:563-79 pubmed publisher
    ..the long-term consequences of genetically impaired angiogenesis by engineering multiple tumor models deprived of endoglin, a co-receptor for TGF-? in endothelial cells actively engaged in angiogenesis...
  31. Ardelean D, Jerkic M, Yin M, Peter M, Ngan B, Kerbel R, et al. Endoglin and activin receptor-like kinase 1 heterozygous mice have a distinct pulmonary and hepatic angiogenic profile and response to anti-VEGF treatment. Angiogenesis. 2014;17:129-46 pubmed publisher
    ..The disease is caused by mutations in endoglin (ENG; HHT1) or activin receptor-like kinase 1 (ALK1; HHT2) genes, coding for transforming growth factor ? (TGF-?) ..
  32. Mancini M, Terzic A, Conley B, Oxburgh L, Nicola T, Vary C. Endoglin plays distinct roles in vascular smooth muscle cell recruitment and regulation of arteriovenous identity during angiogenesis. Dev Dyn. 2009;238:2479-93 pubmed publisher
    Blood vessel formation is a multi-step process. Endoglin is a TGFbeta coreceptor required for angiogenesis. Endoglin null embryos exhibit a loss of arteriovenous identity and defective vascular smooth muscle cell (vSMC) recruitment...
  33. Docherty N, Lopez Novoa J, Arevalo M, Düwel A, Rodriguez Peña A, Perez Barriocanal F, et al. Endoglin regulates renal ischaemia-reperfusion injury. Nephrol Dial Transplant. 2006;21:2106-19 pubmed
    Renal ischaemia-reperfusion (I-R) can cause acute tubular necrosis and chronic renal deterioration. Endoglin, an accessory receptor for Transforming Growth Factor-beta1 (TGF-beta1), is expressed on activated endothelium during macrophage ..
  34. Düwel A, Eleno N, Jerkic M, Arevalo M, Bolanos J, Bernabeu C, et al. Reduced tumor growth and angiogenesis in endoglin-haploinsufficient mice. Tumour Biol. 2007;28:1-8 pubmed
    b>Endoglin is a transforming growth factor-beta(1) (TGF-beta(1)) accessory receptor which is highly expressed in tumor vessels...
  35. Borges L, Iacovino M, Mayerhofer T, Koyano Nakagawa N, Baik J, Garry D, et al. A critical role for endoglin in the emergence of blood during embryonic development. Blood. 2012;119:5417-28 pubmed publisher
    ..Here, we show that endoglin (Eng), a receptor for the TGF? superfamily, identifies all cells with hematopoietic fate in the early embryo...
  36. Ardelean D, Yin M, Jerkic M, Peter M, Ngan B, Kerbel R, et al. Anti-VEGF therapy reduces intestinal inflammation in Endoglin heterozygous mice subjected to experimental colitis. Angiogenesis. 2014;17:641-59 pubmed publisher
    ..b>Endoglin (CD105), a transforming growth factor-? superfamily co-receptor expressed on endothelial and some myeloid cells, ..
  37. Kapur N, Wilson S, Yunis A, Qiao X, Mackey E, Paruchuri V, et al. Reduced endoglin activity limits cardiac fibrosis and improves survival in heart failure. Circulation. 2012;125:2728-38 pubmed publisher
    ..Membrane-associated endoglin is a coreceptor for TGF?1 signaling and has been studied in vascular remodeling and preeclampsia...
  38. Scharpfenecker M, Floot B, Russell N, Ten Dijke P, Stewart F. Endoglin haploinsufficiency reduces radiation-induced fibrosis and telangiectasia formation in mouse kidneys. Radiother Oncol. 2009;92:484-91 pubmed publisher
    b>Endoglin is a transforming growth factor beta (TGF-beta) co-receptor mainly expressed in dividing endothelial cells. It regulates cell proliferation and survival and is upregulated at sites of vessel repair...
  39. Perez Gomez E, Eleno N, Lopez Novoa J, Ramirez J, Velasco B, Letarte M, et al. Characterization of murine S-endoglin isoform and its effects on tumor development. Oncogene. 2005;24:4450-61 pubmed
    Endoglin is a transmembrane glycoprotein that acts as an auxiliary receptor for transforming growth factor-beta (TGF-beta) and modulates cellular responses to this pleiotropic cytokine...
  40. Bourdeau A, Dumont D, Letarte M. A murine model of hereditary hemorrhagic telangiectasia. J Clin Invest. 1999;104:1343-51 pubmed
    b>Endoglin (CD105), an accessory protein of the TGF-beta receptor superfamily, is highly expressed on endothelial cells...
  41. St Jacques S, Cymerman U, Pece N, Letarte M. Molecular characterization and in situ localization of murine endoglin reveal that it is a transforming growth factor-beta binding protein of endothelial and stromal cells. Endocrinology. 1994;134:2645-57 pubmed
    b>Endoglin is an integral membrane glycoprotein predominantly expressed on human endothelial cells and recently shown to bind transforming growth factor-beta 1 (TGF beta 1) with high affinity...
  42. Young K, Krebs L, Tweedie E, Conley B, Mancini M, Arthur H, et al. Endoglin is required in Pax3-derived cells for embryonic blood vessel formation. Dev Biol. 2016;409:95-105 pubmed publisher
    Mutations in endoglin, a TGFβ/BMP coreceptor, are causal for hereditary hemorrhagic telangiectasia (HHT). Endoglin-null (Eng-/-) mouse embryos die at embryonic day (E)10.5-11.5 due to defects in angiogenesis...
  43. Qu X, Zhou B, Scott Baldwin H. Tie1 is required for lymphatic valve and collecting vessel development. Dev Biol. 2015;399:117-128 pubmed publisher
    ..Our findings reveal a fundamental role for Tie1 signaling during lymphatic vessel remodeling and valve morphogenesis and implicate it as a candidate gene involved in primary lymphedema. ..
  44. Spies T, DeMars R. Restored expression of major histocompatibility class I molecules by gene transfer of a putative peptide transporter. Nature. 1991;351:323-4 pubmed
    ..No similar effect was observed in 721.174 mutant cells, in which a homozygous deletion includes PSF among several other closely linked genes. At least one of these genes may therefore also be required for PSF function. ..
  45. Wilson C, Parker L, Hall C, Smyczek T, Mak J, Crow A, et al. Rasip1 regulates vertebrate vascular endothelial junction stability through Epac1-Rap1 signaling. Blood. 2013;122:3678-90 pubmed publisher
    ..Our data show that RASIP1 regulates the integrity of newly formed blood vessels as an effector of EPAC1-RAP1 signaling...
  46. Sugden W, Meissner R, Aegerter Wilmsen T, Tsaryk R, Leonard E, Bussmann J, et al. Endoglin controls blood vessel diameter through endothelial cell shape changes in response to haemodynamic cues. Nat Cell Biol. 2017;19:653-665 pubmed publisher
    ..This is mediated via endothelial cell shape changes. We identify the transforming growth factor beta co-receptor endoglin as an important player in this process...
  47. Wang X, Abraham S, McKenzie J, Jeffs N, Swire M, Tripathi V, et al. LRG1 promotes angiogenesis by modulating endothelial TGF-β signalling. Nature. 2013;499:306-11 pubmed publisher
    ..LRG1 binds directly to the TGF-β accessory receptor endoglin, which, in the presence of TGF-β1, results in promotion of the pro-angiogenic Smad1/5/8 signalling pathway...
  48. Scharpfenecker M, Floot B, Russell N, Coppes R, Stewart F. Endoglin haploinsufficiency attenuates radiation-induced deterioration of kidney function in mice. Radiother Oncol. 2013;108:464-8 pubmed publisher
    b>Endoglin is a transforming growth receptor beta (TGF-?) co-receptor, which plays a crucial role in the development of late normal tissue damage...
  49. Beiroa D, Romero Picó A, Langa C, Bernabeu C, Lopez M, Lopez Novoa J, et al. Heterozygous deficiency of endoglin decreases insulin and hepatic triglyceride levels during high fat diet. PLoS ONE. 2013;8:e54591 pubmed publisher
    b>Endoglin is a transmembrane auxiliary receptor for transforming growth factor-beta (TGF-beta) that is predominantly expressed on proliferating endothelial cells...
  50. Koike S, Keino Masu K, Masu M. Deficiency of autotaxin/lysophospholipase D results in head cavity formation in mouse embryos through the LPA receptor-Rho-ROCK pathway. Biochem Biophys Res Commun. 2010;400:66-71 pubmed publisher
    ..These results reveal the signal transduction defects that underlie the abnormalities in Enpp2(-/-) embryos. ..
  51. Nolan Stevaux O, Zhong W, Culp S, Shaffer K, Hoover J, Wickramasinghe D, et al. Endoglin requirement for BMP9 signaling in endothelial cells reveals new mechanism of action for selective anti-endoglin antibodies. PLoS ONE. 2012;7:e50920 pubmed publisher
    b>Endoglin (ENG), a co-receptor for several TGF?-family cytokines, is expressed in dividing endothelial cells alongside ALK1, the ACVRL1 gene product...
  52. Anderson P, Carrillo Gálvez A, García Pérez A, Cobo M, Martin F. CD105 (endoglin)-negative murine mesenchymal stromal cells define a new multipotent subpopulation with distinct differentiation and immunomodulatory capacities. PLoS ONE. 2013;8:e76979 pubmed publisher
    ..We have found that mMSCs are heterogeneous for endoglin (CD105) expression and that this heterogeneity is not due to different stages of MSC differentiation...
  53. Aristorena M, Blanco F, de Las Casas Engel M, Ojeda Fernandez L, Gallardo Vara E, Corbí A, et al. Expression of endoglin isoforms in the myeloid lineage and their role during aging and macrophage polarization. J Cell Sci. 2014;127:2723-35 pubmed publisher
    b>Endoglin plays a crucial role in pathophysiological processes such as hereditary hemorrhagic telangiectasia (HHT), preeclampsia and cancer...
  54. Tian H, Mythreye K, Golzio C, Katsanis N, Blobe G. Endoglin mediates fibronectin/?5?1 integrin and TGF-? pathway crosstalk in endothelial cells. EMBO J. 2012;31:3885-900 pubmed publisher
    ..specifically increase TGF-?1- and BMP-9-induced Smad1/5/8 phosphorylation via the TGF-? superfamily receptors endoglin and activin-like kinase-1 (ALK1)...
  55. Peter M, Jerkic M, Sotov V, Douda D, Ardelean D, Ghamami N, et al. Impaired resolution of inflammation in the Endoglin heterozygous mouse model of chronic colitis. Mediators Inflamm. 2014;2014:767185 pubmed publisher
    b>Endoglin is a coreceptor of the TGF-β superfamily predominantly expressed on the vascular endothelium and selective subsets of immune cells...
  56. Alejandre Alcazar M, Michiels Corsten M, Vicencio A, Reiss I, Ryu J, de Krijger R, et al. TGF-beta signaling is dynamically regulated during the alveolarization of rodent and human lungs. Dev Dyn. 2008;237:259-69 pubmed
    ..changes in the expression and localization of the TGF-beta receptors Acvrl1, Tgfbr1, Tgfbr2, Tgfbr3, and endoglin, and the intracellular messengers Smad2, Smad3, Smad4, Smad6, and Smad7 were noted as mouse and human lungs ..
  57. Dolinsek T, Markelc B, Bosnjak M, Blagus T, Prosen L, Kranjc S, et al. Endoglin silencing has significant antitumor effect on murine mammary adenocarcinoma mediated by vascular targeted effect. Curr Gene Ther. 2015;15:228-44 pubmed
    New targets and therapeutic approaches for vascular targeted strategies in oncology are continuously explored. Endoglin, a co-receptor of TGF-?, is a known target, however, its silencing with vector-based RNA interference technology has ..
  58. Geske M, Zhang X, Patel K, Ornitz D, Stappenbeck T. Fgf9 signaling regulates small intestinal elongation and mesenchymal development. Development. 2008;135:2959-68 pubmed publisher
    ..Taken together, the interaction of FGF and TGFbeta signaling pathways in the intestinal mesenchyme could represent novel targets for future short bowel syndrome therapies. ..
  59. Chadchan S, Kumar V, Maurya V, Soni U, Jha R. Endoglin (CD105) coordinates the process of endometrial receptivity for embryo implantation. Mol Cell Endocrinol. 2016;425:69-83 pubmed publisher
    b>Endoglin is a TGF-β receptor that is expressed in uterine endothelial and stromal cells in addition to trophoblast expression. However, the functional importance of endoglin in the embryo implantation process is not clear...
  60. Rathouska J, Fikrová P, Mrkvicova A, Blazickova K, Varejckova M, Dolezelova E, et al. High soluble endoglin levels do not induce changes in structural parameters of mouse heart. Heart Vessels. 2017;32:1013-1024 pubmed publisher
    A soluble form of endoglin (sEng) released into the circulation was suggested to be a direct inducer of endothelial dysfunction, inflammation and contributed to the development of hypertension by interfering with TGF-β signaling in ..
  61. Redgrave R, Tual Chalot S, Davison B, Singh E, Hall D, Amirrasouli M, et al. Cardiosphere-Derived Cells Require Endoglin for Paracrine-Mediated Angiogenesis. Stem Cell Reports. 2017;8:1287-1298 pubmed publisher
    ..CDCs express endoglin, a co-receptor that binds specific transforming growth factor β (TGFβ) family ligands, including bone ..
  62. Boroujerdi A, Welser Alves J, Tigges U, Milner R. Chronic cerebral hypoxia promotes arteriogenic remodeling events that can be identified by reduced endoglin (CD105) expression and a switch in ?1 integrins. J Cereb Blood Flow Metab. 2012;32:1820-30 pubmed publisher
    ..for 14 days) alters the size distribution of vessels, number of arteries/arterioles, and expression pattern of endoglin (CD105), a marker of angiogenic endothelial cells in tumors...
  63. Moody J, Singbrant S, Karlsson G, Blank U, Aspling M, Flygare J, et al. Endoglin is not critical for hematopoietic stem cell engraftment and reconstitution but regulates adult erythroid development. Stem Cells. 2007;25:2809-19 pubmed
    b>Endoglin is a transforming growth factor-beta (TGF-beta) accessory receptor recently identified as being highly expressed on long-term repopulating hematopoietic stem cells (HSC)...
  64. Gore B, Izikki M, Mercier O, Dewachter L, Fadel E, Humbert M, et al. Key role of the endothelial TGF-?/ALK1/endoglin signaling pathway in humans and rodents pulmonary hypertension. PLoS ONE. 2014;9:e100310 pubmed publisher
    ..transforming growth factor-beta (TGF-?) superfamily receptors, activin receptor-like kinase (ALK)-1, and endoglin (ENG) occur in patients with pulmonary arterial hypertension (PAH)...
  65. Perez Gomez E, Jerkic M, Prieto M, del Castillo G, Martín Villar E, Letarte M, et al. Impaired wound repair in adult endoglin heterozygous mice associated with lower NO bioavailability. J Invest Dermatol. 2014;134:247-255 pubmed publisher
    Endoglin (Eng) is a transmembrane glycoprotein that is mainly expressed in endothelial cells, but it is also present in the epidermis and skin appendages...