Elovl6

Summary

Gene Symbol: Elovl6
Description: ELOVL family member 6, elongation of long chain fatty acids (yeast)
Alias: C77826, FAE, LCE, elongation of very long chain fatty acids protein 6, 3-keto acyl-CoA synthase Elovl6, ELOVL FA elongase 6, ELOVL fatty acid elongase 6, fatty acyl-CoA elongase, long chain fatty acid elongase, long chain fatty acyl elongase, myelin-associated SUR4 protein, very long chain 3-ketoacyl-CoA synthase 6, very long chain 3-oxoacyl-CoA synthase 6
Species: mouse
Products:     Elovl6

Top Publications

  1. Kumadaki S, Matsuzaka T, Kato T, Yahagi N, Yamamoto T, Okada S, et al. Mouse Elovl-6 promoter is an SREBP target. Biochem Biophys Res Commun. 2008;368:261-6 pubmed publisher
    ..EMSA indicated that SRE-1 had higher affinity than SRE-2 for SREBP. ChIP assays confirmed in vivo binding of hepatic nuclear SREBP-1c protein. These data demonstrated that Elovl-6 is regulated directly and primarily by SREBP-1c. ..
  2. Shimano H. Novel qualitative aspects of tissue fatty acids related to metabolic regulation: lessons from Elovl6 knockout. Prog Lipid Res. 2012;51:267-71 pubmed publisher
    ..As a target gene of SREBP-1 that controls lipogenesis we identified a unique enzyme, Elovl6, which is responsible for the final step in endogenous saturated fatty acid synthesis, thereby controlling tissue ..
  3. Moon Y, Shah N, Mohapatra S, Warrington J, Horton J. Identification of a mammalian long chain fatty acyl elongase regulated by sterol regulatory element-binding proteins. J Biol Chem. 2001;276:45358-66 pubmed
    ..Here, we report the cDNA cloning of a murine long chain fatty acyl elongase (LCE) that was identified initially by oligonucleotide array analysis of mRNA from SREBP transgenic ..
  4. Matsuzaka T, Shimano H, Yahagi N, Yoshikawa T, Amemiya Kudo M, Hasty A, et al. Cloning and characterization of a mammalian fatty acyl-CoA elongase as a lipogenic enzyme regulated by SREBPs. J Lipid Res. 2002;43:911-20 pubmed
  5. Moon Y, Horton J. Identification of two mammalian reductases involved in the two-carbon fatty acyl elongation cascade. J Biol Chem. 2003;278:7335-43 pubmed
    ..We previously reported the cDNA cloning and characterization of a murine long chain fatty acyl elongase (LCE) ...
  6. Matsuzaka T, Shimano H, Yahagi N, Kato T, Atsumi A, Yamamoto T, et al. Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance. Nat Med. 2007;13:1193-202 pubmed
    ..Mice deficient for Elovl6, the gene encoding the elongase that catalyzes the conversion of palmitate to stearate, were generated and shown ..
  7. Saito R, Matsuzaka T, Karasawa T, Sekiya M, Okada N, Igarashi M, et al. Macrophage Elovl6 deficiency ameliorates foam cell formation and reduces atherosclerosis in low-density lipoprotein receptor-deficient mice. Arterioscler Thromb Vasc Biol. 2011;31:1973-9 pubmed publisher
    b>Elovl6, a long-chain fatty acid elongase, is a rate-limiting enzyme that elongates saturated and monounsaturated fatty acids and has been shown to be related to obesity-induced insulin resistance via modification of fatty acid composition...
  8. Nagarajan R, Le N, Mahoney H, Araki T, Milbrandt J. Deciphering peripheral nerve myelination by using Schwann cell expression profiling. Proc Natl Acad Sci U S A. 2002;99:8998-9003 pubmed
    ..Its specific localization in myelinating Schwann cells indicates a crucial role for MASR in normal myelin lipid synthesis. ..
  9. Tang N, Matsuzaka T, Suzuki M, Nakano Y, Zao H, Yokoo T, et al. Ablation of Elovl6 protects pancreatic islets from high-fat diet-induced impairment of insulin secretion. Biochem Biophys Res Commun. 2014;450:318-23 pubmed publisher
    ELOVL family member 6, elongation of very long-chain fatty acids (Elovl6) is a microsomal enzyme that regulates the elongation of C12-16 saturated and monounsaturated fatty acids and is related to the development of obesity-induced ..

More Information

Publications22

  1. Olson L, Zhang J, Taylor H, Rose D, Rosenfeld M. Barx2 functions through distinct corepressor classes to regulate hair follicle remodeling. Proc Natl Acad Sci U S A. 2005;102:3708-13 pubmed
    ..Together, our data suggest that the hair-remodeling defect of Barx2 mutant mice could be explained, in part, by failure to repress one or more critical target genes. ..
  2. Kuba M, Matsuzaka T, Matsumori R, Saito R, Kaga N, Taka H, et al. Absence of Elovl6 attenuates steatohepatitis but promotes gallstone formation in a lithogenic diet-fed Ldlr(-/-) mouse model. Sci Rep. 2015;5:17604 pubmed publisher
    ..Elongation of very long chain fatty acids (ELOVL) family member 6 (Elovl6) is a microsomal enzyme that regulates the elongation of C12-16 saturated and monounsaturated fatty acids (FAs)...
  3. Sassa T, Ohno Y, Suzuki S, Nomura T, Nishioka C, Kashiwagi T, et al. Impaired epidermal permeability barrier in mice lacking elovl1, the gene responsible for very-long-chain fatty acid production. Mol Cell Biol. 2013;33:2787-96 pubmed publisher
    ..Elovl1 is a key determinant of epidermal Cer chain length and is essential for permeability barrier formation. ..
  4. Beigneux A, Kosinski C, Gavino B, Horton J, Skarnes W, Young S. ATP-citrate lyase deficiency in the mouse. J Biol Chem. 2004;279:9557-64 pubmed
    ..The Acly knockout allele is useful for identifying cell types with a high demand for acetyl-CoA synthesis. ..
  5. Zhao H, Matsuzaka T, Nakano Y, Motomura K, Tang N, Yokoo T, et al. Elovl6 Deficiency Improves Glycemic Control in Diabetic db/db Mice by Expanding ?-Cell Mass and Increasing Insulin Secretory Capacity. Diabetes. 2017;66:1833-1846 pubmed publisher
    ..b>Elovl6 is a microsomal enzyme that is responsible for converting C16 saturated and monounsaturated FAs into C18 species...
  6. Tan C, Virtue S, Bidault G, Dale M, Hagen R, Griffin J, et al. Brown Adipose Tissue Thermogenic Capacity Is Regulated by Elovl6. Cell Rep. 2015;13:2039-47 pubmed publisher
    ..In this study, we demonstrate that the enzyme Elongation of Very Long Chain fatty acids 6 (Elovl6) is necessary for the thermogenic action of BAT...
  7. Moon Y, Ochoa C, Mitsche M, Hammer R, Horton J. Deletion of ELOVL6 blocks the synthesis of oleic acid but does not prevent the development of fatty liver or insulin resistance. J Lipid Res. 2014;55:2597-605 pubmed publisher
    Elongation of very long chain fatty acid-like family member 6 (ELOVL6) is a fatty acyl elongase that performs the initial and rate-limiting condensing reaction required for microsomal elongation of long-chain fatty acids...
  8. Matsuzaka T, Shimano H. Elovl6: a new player in fatty acid metabolism and insulin sensitivity. J Mol Med (Berl). 2009;87:379-84 pubmed publisher
    ..This review addresses the hypothesis that elongation of long-chain fatty acids family member 6 (Elovl6) has an important role in energy metabolism and insulin sensitivity...
  9. Shimano H. [Quality aspects of lipid accumulation in insulin resistance--a lesson from long fatty acid elongase, Elovl-6]. Seikagaku. 2008;80:762-7 pubmed
  10. Matsuzaka T, Atsumi A, Matsumori R, Nie T, Shinozaki H, Suzuki Kemuriyama N, et al. Elovl6 promotes nonalcoholic steatohepatitis. Hepatology. 2012;56:2199-208 pubmed publisher
    ..ELOVL family member 6, elongation of very long chain fatty acids (Elovl6), is a microsomal enzyme that regulates the elongation of C12-16 saturated and monounsaturated fatty acids (FAs)...
  11. Kikuchi M, Shimada M, Matsuzaka T, Ishii K, Nakagawa Y, Takayanagi M, et al. Crucial Role of Elovl6 in Chondrocyte Growth and Differentiation during Growth Plate Development in Mice. PLoS ONE. 2016;11:e0159375 pubmed publisher
    ELOVL family member 6, elongation of very long chain fatty acids (Elovl6) is a microsomal enzyme, which regulates the elongation of C12-16 saturated and monounsaturated fatty acids...
  12. Sunaga H, Matsui H, Ueno M, Maeno T, Iso T, Syamsunarno M, et al. Deranged fatty acid composition causes pulmonary fibrosis in Elovl6-deficient mice. Nat Commun. 2013;4:2563 pubmed publisher
    ..The elongation of long-chain fatty acids family member 6 (Elovl6) is a rate-limiting enzyme catalysing the elongation of saturated and monounsaturated fatty acids...
  13. Bae J, Oh A, Lee H, Ahn Y, Cha J. Hepatic Elovl6 gene expression is regulated by the synergistic action of ChREBP and SREBP-1c. Biochem Biophys Res Commun. 2016;478:1060-6 pubmed publisher
    b>Elongation of very long chain fatty acids protein 6 (ELOVL6), a rate-limiting enzyme for the elongation of saturated and monounsaturated fatty acids with 12, 14, and 16 carbons, plays a key role in energy metabolism and insulin ..