Elovl2

Summary

Gene Symbol: Elovl2
Description: elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 2
Alias: AI317360, Ssc2, elongation of very long chain fatty acids protein 2, 3-keto acyl-CoA synthase Elovl2, ELOVL FA elongase 2, ELOVL family member 2, ELOVL fatty acid elongase 2, sequence similarity to Cig30 2, very long chain 3-ketoacyl-CoA synthase 2, very long chain 3-oxoacyl-CoA synthase 2
Species: mouse

Top Publications

  1. pmc Role of a new mammalian gene family in the biosynthesis of very long chain fatty acids and sphingolipids
    P Tvrdik
    The Wenner Gren Institute, The Arrhenius Laboratories F3, Stockholm University, SE 106 91 Stockholm, Sweden
    J Cell Biol 149:707-18. 2000
  2. ncbi Identification of a mammalian long chain fatty acyl elongase regulated by sterol regulatory element-binding proteins
    Y A Moon
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9046, USA
    J Biol Chem 276:45358-66. 2001
  3. ncbi ELOVL2 overexpression enhances triacylglycerol synthesis in 3T3-L1 and F442A cells
    Tsutomu Kobayashi
    Wenner Gren Institute, Arrhenius Laboratories F3, Stockholm University, Stockholm, Sweden
    FEBS Lett 581:3157-63. 2007
  4. pmc ELOVL2 controls the level of n-6 28:5 and 30:5 fatty acids in testis, a prerequisite for male fertility and sperm maturation in mice
    Damir Zadravec
    The Wenner Gren Institute, Arrhenius Laboratories F3, Stockholm University, Stockholm, Sweden
    J Lipid Res 52:245-55. 2011
  5. pmc Impaired epidermal permeability barrier in mice lacking elovl1, the gene responsible for very-long-chain fatty acid production
    Takayuki Sassa
    Laboratory of Biochemistry, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
    Mol Cell Biol 33:2787-96. 2013
  6. pmc Elovl2 ablation demonstrates that systemic DHA is endogenously produced and is essential for lipid homeostasis in mice
    Anna M Pauter
    Department of Molecular Biosciences, The Wenner Gren Institute, Stockholm University, SE 10691 Stockholm, Sweden and
    J Lipid Res 55:718-28. 2014
  7. pmc Both maternal and offspring Elovl2 genotypes determine systemic DHA levels in perinatal mice
    Anna M Pauter
    Department of Molecular Biosciences, Wenner Gren Institute, Stockholm University, Stockholm, SE 10691 Sweden
    J Lipid Res 58:111-123. 2017
  8. ncbi Identification and expression of mammalian long-chain PUFA elongation enzymes
    Amanda E Leonard
    Ross Products Division, Abbott Laboratories, Columbus, Ohio 43215, USA
    Lipids 37:733-40. 2002

Scientific Experts

  • P Tvrdik
  • Tsutomu Kobayashi
  • Anna M Pauter
  • Anders Jacobsson
  • Damir Zadravec
  • Abolfazl Asadi
  • Takayuki Sassa
  • Olga Dethlefsen
  • Sofia Trattner
  • Amanda Gonzalez-Bengtsson
  • Emanuela Talamonti
  • Amanda E Leonard
  • Bengt Herslöf
  • Robert I Csikasz
  • Petter Olsson
  • Masashi Akiyama
  • Chieko Nishioka
  • Shigeyoshi Itohara
  • Ryo Taguchi
  • Taisuke Hirayama
  • Toshiki Kashiwagi
  • Shotaro Suzuki
  • Hiroshi Shimizu
  • Yusuke Ohno
  • Akio Kihara
  • Toshifumi Nomura
  • Y A Moon
  • Herve Guillou
  • Mario R Capecchi
  • Richard Haslam
  • Johnathan A Napier
  • Emil G Bobik
  • John J Kopchick
  • Pradip Mukerji
  • Yung Sheng Huang
  • Lu Te Chuang
  • Bruce Kelder
  • Christopher J Lewis
  • S Mohapatra
  • J A Warrington
  • N A Shah
  • J D Horton

Detail Information

Publications8

  1. pmc Role of a new mammalian gene family in the biosynthesis of very long chain fatty acids and sphingolipids
    P Tvrdik
    The Wenner Gren Institute, The Arrhenius Laboratories F3, Stockholm University, SE 106 91 Stockholm, Sweden
    J Cell Biol 149:707-18. 2000
    ..The Ssc1 gene appears to be ubiquitously expressed, whereas Ssc2 and Cig30 show a restricted expression pattern...
  2. ncbi Identification of a mammalian long chain fatty acyl elongase regulated by sterol regulatory element-binding proteins
    Y A Moon
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9046, USA
    J Biol Chem 276:45358-66. 2001
    ..The current studies suggest that mouse LCE expression is increased by SREBPs and that the enzyme is a component of the elusive mammalian elongation system that converts palmitic to stearic acid...
  3. ncbi ELOVL2 overexpression enhances triacylglycerol synthesis in 3T3-L1 and F442A cells
    Tsutomu Kobayashi
    Wenner Gren Institute, Arrhenius Laboratories F3, Stockholm University, Stockholm, Sweden
    FEBS Lett 581:3157-63. 2007
    Elongation of very long-chain fatty acids (ELOVL) members were overexpressed in two preadipocyte cell lines, ELOVL2 and ELOVL3 in 3T3-L1 cells, and ELOVL1-3 in F442A cells...
  4. pmc ELOVL2 controls the level of n-6 28:5 and 30:5 fatty acids in testis, a prerequisite for male fertility and sperm maturation in mice
    Damir Zadravec
    The Wenner Gren Institute, Arrhenius Laboratories F3, Stockholm University, Stockholm, Sweden
    J Lipid Res 52:245-55. 2011
    b>ELOVL2 is a member of the mammalian microsomal ELOVL fatty acid enzyme family, involved in the elongation of very long-chain fatty acids including PUFAs required for various cellular functions in mammals...
  5. pmc Impaired epidermal permeability barrier in mice lacking elovl1, the gene responsible for very-long-chain fatty acid production
    Takayuki Sassa
    Laboratory of Biochemistry, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
    Mol Cell Biol 33:2787-96. 2013
    ..Elovl1 is a key determinant of epidermal Cer chain length and is essential for permeability barrier formation. ..
  6. pmc Elovl2 ablation demonstrates that systemic DHA is endogenously produced and is essential for lipid homeostasis in mice
    Anna M Pauter
    Department of Molecular Biosciences, The Wenner Gren Institute, Stockholm University, SE 10691 Stockholm, Sweden and
    J Lipid Res 55:718-28. 2014
    ..of very long-chain fatty acids (ELOVLs) in mammals is catalyzed by the ELOVL enzymes to which the PUFA elongase ELOVL2 belongs...
  7. pmc Both maternal and offspring Elovl2 genotypes determine systemic DHA levels in perinatal mice
    Anna M Pauter
    Department of Molecular Biosciences, Wenner Gren Institute, Stockholm University, Stockholm, SE 10691 Sweden
    J Lipid Res 58:111-123. 2017
    ..In order to address the question regarding the origin of DHA during perinatal life, we have used DHA-deficient Elovl2-ablated mice as a model system to analyze the maternal impact on the DHA level in their offspring of various ..
  8. ncbi Identification and expression of mammalian long-chain PUFA elongation enzymes
    Amanda E Leonard
    Ross Products Division, Abbott Laboratories, Columbus, Ohio 43215, USA
    Lipids 37:733-40. 2002
    ..4 and 58% identity, respectively, to that of ELOVL5. The open reading frame of the human clone (ELOVL2) encodes a 296-amino acid peptide, whereas the mouse clone (Elovl2) encodes a 292-amino acid peptide...