Gene Symbol: Eloc
Description: elongin C
Alias: 2610043E24Rik, 2610301I15Rik, AA407206, AI987979, AW049146, Tceb1, elongin-C, transcription elongation factor B polypeptide 1, RNA polymerase II transcription factor SIII subunit C, SIII p15, elongin 15 kDa subunit, stromal membrane-associated protein SMAP1B homolog, transcription elongation factor B (SIII), polypeptide 1
Species: mouse
Products:     Eloc

Top Publications

  1. Kamura T, Burian D, Yan Q, Schmidt S, Lane W, Querido E, et al. Muf1, a novel Elongin BC-interacting leucine-rich repeat protein that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin ligase. J Biol Chem. 2001;276:29748-53 pubmed
    ..Taken together, our findings identify MUF1 as a new member of the BC-box family of proteins, and they predict the existence of a larger family of Elongin BC-based E3 ubiquitin ligases. ..
  2. Nastasi T, Bongiovanni A, Campos Y, Mann L, Toy J, Bostrom J, et al. Ozz-E3, a muscle-specific ubiquitin ligase, regulates beta-catenin degradation during myogenesis. Dev Cell. 2004;6:269-82 pubmed
    ..These findings reveal a novel mechanism of regulation of Mb-beta-catenin and the role of this pool of the protein in myofibrillogenesis, and implicate the Ozz-E3 ligase in the process of myofiber differentiation. ..
  3. Limnander A, Danial N, Rothman P. v-Abl signaling disrupts SOCS-1 function in transformed pre-B cells. Mol Cell. 2004;15:329-41 pubmed
    ..These findings reveal a mechanism by which Jak-dependent oncogenes may bypass SOCS-1 inhibition. ..
  4. Perry E, Tsruya R, Levitsky P, Pomp O, Taller M, Weisberg S, et al. TMF/ARA160 is a BC-box-containing protein that mediates the degradation of Stat3. Oncogene. 2004;23:8908-19 pubmed
    ..sequence analysis identified a BC-box element in TMF/ARA160 that mediated the binding of this protein to elongin C. Ectopic expression of TMF/ARA160 in serum-starved C2C12 cells drove the ubiquitination and proteasomal ..
  5. Liefke R, Karwacki Neisius V, Shi Y. EPOP Interacts with Elongin BC and USP7 to Modulate the Chromatin Landscape. Mol Cell. 2016;64:659-672 pubmed publisher
    ..Our findings establish EPOP as a transcriptional modulator, which impacts both Polycomb and active gene transcription in mammalian cells. ..
  6. Yu C, Ji S, Sha Q, Dang Y, Zhou J, Zhang Y, et al. BTG4 is a meiotic cell cycle-coupled maternal-zygotic-transition licensing factor in oocytes. Nat Struct Mol Biol. 2016;23:387-94 pubmed publisher
    ..This is a key step in oocyte cytoplasmic maturation that determines the developmental potential of mammalian embryos. ..
  7. Kim Y, Kwak M, Ku B, Suh H, Joo K, Lee J, et al. Structural basis of intersubunit recognition in elongin BC-cullin 5-SOCS box ubiquitin-protein ligase complexes. Acta Crystallogr D Biol Crystallogr. 2013;69:1587-97 pubmed publisher
    ..This study provides structural bases underlying the specificity of Cul5 and Cul2 for elongin BC and their preferential association with Cul5 or Cul2 box-containing substrate receptors. ..
  8. Zhang J, Farley A, Nicholson S, Willson T, Zugaro L, Simpson R, et al. The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation. Proc Natl Acad Sci U S A. 1999;96:2071-6 pubmed
    ..Analogous to the family of F-box-containing proteins, it appears that the SOCS proteins may act as adaptor molecules that target activated cell signaling proteins to the protein degradation pathway. ..
  9. Wadelin F, Fulton J, Collins H, Tertipis N, Bottley A, Spriggs K, et al. PRAME is a golgi-targeted protein that associates with the Elongin BC complex and is upregulated by interferon-gamma and bacterial PAMPs. PLoS ONE. 2013;8:e58052 pubmed publisher
    ..Affinity purification studies revealed that PRAME associates with Elongin B and Elongin C, components of Cullin E3 ubiquitin ligase complexes...

More Information


  1. Lavens D, Montoye T, Piessevaux J, Zabeau L, Vandekerckhove J, Gevaert K, et al. A complex interaction pattern of CIS and SOCS2 with the leptin receptor. J Cell Sci. 2006;119:2214-24 pubmed
    ..This unexpected interference can be explained by the direct binding of SOCS2 on the CIS SOCS box, whereby elongin B/C recruitment is crucial to suppress CIS activity. ..
  2. Woo J, Imm J, Min C, Kim K, Cha S, Oh B. Structural and functional insights into the B30.2/SPRY domain. EMBO J. 2006;25:1353-63 pubmed
    ..2/SPRY domains, suggesting that these domains are protein-interacting modules, which recognize a specific individual partner protein rather than a consensus sequence motif. ..
  3. Babon J, Sabo J, Soetopo A, Yao S, Bailey M, Zhang J, et al. The SOCS box domain of SOCS3: structure and interaction with the elonginBC-cullin5 ubiquitin ligase. J Mol Biol. 2008;381:928-40 pubmed publisher
    ..Domains upstream of the SOCS box are not required for elonginBC or cullin5 association, indicating that the SOCS box acts as an independent binding domain capable of recruiting elonginBC and cullin5 to promote E3 ligase formation. ..
  4. Wilson C, Crombie C, van der Weyden L, Poulogiannis G, Rust A, Pardo M, et al. Nuclear receptor binding protein 1 regulates intestinal progenitor cell homeostasis and tumour formation. EMBO J. 2012;31:2486-97 pubmed publisher
    ..Thus NRBP1 is a conserved regulator of cell fate, that plays an important role in tumour suppression. ..
  5. Kamura T, Maenaka K, Kotoshiba S, Matsumoto M, Kohda D, Conaway R, et al. VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases. Genes Dev. 2004;18:3055-65 pubmed
    ..These data suggest that the functions of the Cul2-Rbx1 and Cul5-Rbx2 modules are distinct. ..
  6. Beringer M, Pisano P, Di Carlo V, Blanco E, Chammas P, Vizan P, et al. EPOP Functionally Links Elongin and Polycomb in Pluripotent Stem Cells. Mol Cell. 2016;64:645-658 pubmed publisher
    ..Our results indicate that keeping the balance between activating and repressive cues is a more general feature of chromatin in pluripotent stem cells than previously appreciated. ..
  7. Jalava S, Porkka K, Rauhala H, Isotalo J, Tammela T, Visakorpi T. TCEB1 promotes invasion of prostate cancer cells. Int J Cancer. 2009;124:95-102 pubmed publisher
    ..We have previously shown that TCEB1, EIF3S3, KIAA0196 and RAD21 are amplified and overexpressed in prostate cancer and they are located in the 8q area...
  8. Campos Y, Qiu X, Zanoteli E, Moshiach S, Vergani N, Bongiovanni A, et al. Ozz-E3 ubiquitin ligase targets sarcomeric embryonic myosin heavy chain during muscle development. PLoS ONE. 2010;5:e9866 pubmed publisher
    ..Our findings identify Ozz-E3 as the ubiquitin ligase complex that interacts with and regulates myosin within its fully assembled cytoskeletal structure. ..
  9. Desimone M, Rathmell W, Threadgill D. Pleiotropic effects of the trichloroethylene-associated P81S VHL mutation on metabolism, apoptosis, and ATM-mediated DNA damage response. J Natl Cancer Inst. 2013;105:1355-64 pubmed publisher
    ..The TCE-associated P81S VHL mutation can initiate a unique adaptive response required for selective tumor growth through pleiotropic effects on metabolic diversification, apoptosis suppression, and alteration of the DNA damage response. ..
  10. Piessevaux J, De Ceuninck L, Catteeuw D, Peelman F, Tavernier J. Elongin B/C recruitment regulates substrate binding by CIS. J Biol Chem. 2008;283:21334-46 pubmed publisher
    ..Our findings indicate that the SOCS box not only plays a role in the formation of E3 ligase complexes but, at least for CIS, can also regulate the binding modus of SOCS box-containing proteins. ..
  11. Kamura T, Sato S, Haque D, Liu L, Kaelin W, Conaway R, et al. The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families. Genes Dev. 1998;12:3872-81 pubmed
    ..Elongin B is a ubiquitin-like protein, and Elongin C is a Skp1-like protein that binds to a BC-box motif that is present in both Elongin A and VHL and is distinct ..