Eloa

Summary

Gene Symbol: Eloa
Description: elongin A
Alias: 110kDa, AA408125, Tceb3, Tceb3a, elongin-A, RNA polymerase II transcription factor SIII subunit A1, SIII p110, elongin 110 kDa subunit, transcription elongation factor B polypeptide 3
Species: mouse
Products:     Eloa

Top Publications

  1. de Buhr M, Mahler M, Geffers R, Hansen W, Westendorf A, Lauber J, et al. Cd14, Gbp1, and Pla2g2a: three major candidate genes for experimental IBD identified by combining QTL and microarray analyses. Physiol Genomics. 2006;25:426-34 pubmed
    ..Strain differences for them are already known or are shown in this study. ..
  2. Yasukawa T, Sugimura K, Fukuda M, Yamazaki K, Kitajima S, Okumura K, et al. Functional characterization of a mammalian transcription factor, Elongin A. Biochem Biophys Res Commun. 2007;352:237-43 pubmed
    b>Elongin A is the transcriptionally active subunit of the Elongin complex that strongly stimulates the rate of elongation by RNA polymerase II (pol II) by suppressing the transient pausing of the polymerase at many sites along the DNA ..
  3. Yasukawa T, Kamura T, Kitajima S, Conaway R, Conaway J, Aso T. Mammalian Elongin A complex mediates DNA-damage-induced ubiquitylation and degradation of Rpb1. EMBO J. 2008;27:3256-66 pubmed publisher
    ..degradation of the largest subunit of pol II (Rpb1) following UV-irradiation are significantly suppressed in Elongin A-deficient cells; however, in both cases suppression is rescued by transfection of wild-type Elongin A...
  4. Yasukawa T, Bhatt S, Takeuchi T, Kawauchi J, Takahashi H, Tsutsui A, et al. Transcriptional elongation factor elongin A regulates retinoic acid-induced gene expression during neuronal differentiation. Cell Rep. 2012;2:1129-36 pubmed publisher
    b>Elongin A increases the rate of RNA polymerase II (pol II) transcript elongation by suppressing transient pausing by the enzyme...
  5. Ardehali M, Anselmo A, Cochrane J, Kundu S, Sadreyev R, Kingston R. Polycomb Repressive Complex 2 Methylates Elongin A to Regulate Transcription. Mol Cell. 2017;68:872-884.e6 pubmed publisher
    ..The RNA polymerase II (Pol II) transcription elongation factor, Elongin A (EloA), is methylated by PRC2 in vivo...
  6. Aso T, Amimoto K, Takebayashi S, Okumura K, Hatakeyama M. Structural organization and chromosome location of the mouse elongin A gene (Tceb3). Cytogenet Cell Genet. 1999;86:259-62 pubmed
    b>Elongin A is the transcriptionally active subunit of the Elongin complex, which strongly increases the rate of elongation by RNA polymerase II by suppressing the transient pausing of the polymerase at many sites within transcription ..
  7. Yamazaki K, Aso T, Ohnishi Y, Ohno M, Tamura K, Shuin T, et al. Mammalian elongin A is not essential for cell viability but is required for proper cell cycle progression with limited alteration of gene expression. J Biol Chem. 2003;278:13585-9 pubmed
    b>Elongin A is a transcription elongation factor that increases the overall rate of mRNA chain elongation by RNA polymerase II...
  8. Miyata K, Yasukawa T, Fukuda M, Takeuchi T, Yamazaki K, Sakumi K, et al. Induction of apoptosis and cellular senescence in mice lacking transcription elongation factor, Elongin A. Cell Death Differ. 2007;14:716-26 pubmed
    b>Elongin A is a transcription elongation factor that increases the overall rate of mRNA chain elongation by RNA polymerase II. To gain more insight into the physiological functions of Elongin A, we generated Elongin A-deficient mice...
  9. Ding L, Paszkowski Rogacz M, Nitzsche A, Slabicki M, Heninger A, de Vries I, et al. A genome-scale RNAi screen for Oct4 modulators defines a role of the Paf1 complex for embryonic stem cell identity. Cell Stem Cell. 2009;4:403-15 pubmed publisher
    ..We propose that the Paf1C plays an important role in maintaining ESC identity. ..

More Information

Publications10

  1. Kawauchi J, Inoue M, Fukuda M, Uchida Y, Yasukawa T, Conaway R, et al. Transcriptional properties of mammalian elongin A and its role in stress response. J Biol Chem. 2013;288:24302-15 pubmed publisher
    b>Elongin A was shown previously to be capable of potently activating the rate of RNA polymerase II (RNAPII) transcription elongation in vitro by suppressing transient pausing by the enzyme at many sites along DNA templates...